90 results about "Gastric fluid" patented technology

The invention belongs to the technical field of preparation of biological materials, and particularly discloses a sea cucumber flower self-assembled polypeptide-iron nano-carrier as well as a preparation method and application of the sea cucumber flower self-assembled polypeptide-iron nano-carrier. The preparation method comprises the following steps: dissolving freeze-dried sea cucumber flower powder in deionized water, adjusting the pH value to be alkaline, heating and stirring, centrifuging, discarding the precipitate, adjusting the pH value to be acidic, centrifuging, collecting the precipitate, and freeze-drying to obtain sea cucumber flower protein powder; preparing a reaction solution, adding simulated gastric juice and simulated intestinal juice, stirring for reaction, inactivating protease, centrifuging, taking supernatant, and freeze-drying to obtain sea cucumber flower self-assembled polypeptide; the preparation method comprises the following steps: preparing a solution from sea cucumber, adding FeCl2. 4H2O and ascorbic acid, adjusting the pH value to be acidic, carrying out heating reaction, centrifuging, discarding the supernatant, and freeze-drying to obtain the sea cucumber flower self-assembled polypeptide-iron nano-carrier. The invention discloses a sea cucumber flower self-assembled polypeptide-iron nano-carrier as well as a preparation method and application thereof. The carrier can promote absorption of an organism to iron, a relatively high iron ion release rate is maintained in an intestinal environment, and the in-vivo bioavailability of iron ions is improved.

The invention discloses a sea cucumber flower self-assembled polypeptide-selenium nano-carrier with antioxidant activity and a preparation method and application thereof, belongs to the technical field of functional protein peptides, and particularly relates to a preparation method of the sea cucumber flower self-assembled polypeptide-selenium nano-carrier with antioxidant activity, which comprises the following steps: heating a sea cucumber flower protein solution; the preparation method comprises the following steps: mixing sea cucumber with simulated gastric juice, reacting for 30-150 minutes, then adding simulated intestinal juice, reacting for 20-120 minutes, carrying out enzyme deactivation treatment, centrifuging, taking supernate, and freeze-drying to obtain sea cucumber flower self-assembled polypeptide; and mixing the sea cucumber flower self-assembled polypeptide with deionized water to prepare a sea cucumber flower self-assembled polypeptide solution, mixing the sea cucumber flower self-assembled polypeptide solution with a sodium selenite solution and a phosphate buffer solution, reacting for 20-60 minutes, washing with an ethanol solution, centrifugally collecting precipitate, and freeze-drying to obtain the sea cucumber flower self-assembled polypeptide-selenium nano-carrier. The sea cucumber flower self-assembled polypeptide-selenium nano-carrier prepared by the invention has good antioxidant activity and potential of effectively delivering selenium to an organism.

The present invention discloses a nasogastric feeding device for nursing the digestive tract with anti-backflow, which relates to the field of nasogastric feeding technology, including a feeding device and a hose, wherein the feeding device includes a driving rod and a housing, the upper and lower ends of the housing are respectively provided with end caps and a sleeve, a pressing plate and a mesh plate are installed inside the housing, a cavity is formed between the end cap and the sleeve, a four-way pipe is installed on the end cap, an air pump and a control valve are installed inside the four-way pipe, the pressing plate and the mesh plate are provided with a driving rod, and the four ports of the four-way pipe are respectively connected to the external environment, the cavity, the air pump and the space inside the housing. The present invention performs air extraction before food processing to prevent the liquid food from carrying a large amount of air into the patient's stomach during the infusion period, thereby preventing the patient from experiencing bloating. At the same time, the hose is provided with an anti-backflow mechanism to prevent the phenomenon of gastric fluid backflow due to the patient's body posture.

This invention belongs to the field of microbial technology, specifically relating to a strain of *Pediococcus pentosaceus* SUN02 with acetylcholinesterase inhibitory activity and its applications. This *Pediococcus pentosaceus* SUN02 is deposited at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC No. 29705. The *Pediococcus pentosaceus* SUN02 provided by this invention exhibits strong acid and bile salt resistance, good tolerance in simulated gastric and intestinal fluids, and can successfully reach the human intestine. *Pediococcus pentosaceus* SUN02, in its bacterial suspension and inactivated cells, possesses strong acetylcholinesterase inhibitory activity, produces γ-aminobutyric acid (GABA), and has antioxidant and other probiotic functions. Its application in probiotic products may help improve Alzheimer's disease, enhance learning and memory abilities, regulate mood, and improve sleep.

The invention relates to the technical field of biological medicine, and discloses bifidobacterium adolescentis YF-01 and application thereof in fermented milk. The bifidobacterium adolescentis YF-01 is separated from adult excrement and is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 20251308. Experiments prove that the bifidobacterium adolescentis YF-01 has good gastrointestinal fluid tolerance, the survival rate of the bifidobacterium adolescentis YF-01 can reach 90.1% after simulated gastric fluid treatment for 3 h, and the survival rate of the bifidobacterium adolescentis YF-01 can reach 72% after simulated intestinal fluid treatment for 4 h The strain has the self-aggregation rate of 88.83% and the hydrophobicity of 79.41%, has remarkable scavenging capacity on DPPH free radicals and hydroxyl free radicals, shows good antioxidant activity and adhesion capacity, and provides a theoretical basis for application of the strain in fermented milk. The strain and metabolites thereof can be used for preparing food, medicines or health care products capable of regulating intestinal flora and enhancing oxidation resistance, and have remarkable application potential in development of functional fermented milk products.

The invention provides a pet hair decomposer with synergistic effect of bacillus subtilis and keratinase, the pet hair decomposer comprises bacillus subtilis ZYpet-015 and keratinase, the preservation number of the bacillus subtilis ZYpet-015 is CGMCC (China General Microbiological Culture Collection Center) No.34790, and the preservation date is June 6, 2025; the protease activity of the bacillus subtilis is greater than or equal to 129.92 U, the survival rate of the bacillus subtilis in simulated gastric juice within 3 hours is greater than 50%, and the tolerance rate of the bacillus subtilis in intestinal juice within 4 hours is greater than 90%. According to the pet hair decomposing agent, hair keratin is synergistically degraded through protease secreted by the bacillus subtilis ZYpet-015 and keratinase, and the hair decomposing efficiency reaches 28.07% + / -2.79% and is remarkably higher than that of a single treatment group. Meanwhile, experiments prove that the pet hair decomposer can effectively destroy the hair cuticle structure, is suitable for a pet hair-melting nutritional supplement and can relieve the hair ball symptom.

The invention relates to the technical field of microorganisms, in particular to lactobacillus plantarum, selenium-rich lactobacillus plantarum and application thereof. The lactobacillus plantarum with the preservation number of GDMCC No: 64006 is provided, selenium is enriched through the lactobacillus plantarum, and inorganic selenium is converted into biological nano-selenium which can be preserved in vivo for a longer time. The invention provides a technical scheme that lactobacillus plantarum is subjected to selenium-enriched culture to prepare the selenium-enriched lactobacillus plantarum, the elimination capability of the prepared selenium-enriched lactobacillus plantarum to free radicals DPPH and ABTS < + > and the endurance capability of the prepared selenium-enriched lactobacillus plantarum to simulated gastric juice can be remarkably improved, and the tolerance of the prepared selenium-enriched lactobacillus plantarum to cholate and simulated artificial intestinal juice cannot be reduced; meanwhile, the AIEC associated colitis can be relieved from the aspects of accelerating weight recovery, reducing colon tissue pathological damage, reducing AIEC colonization, promoting intestinal barrier repair, reducing the proinflammatory factor level, improving the selenium level, improving intestinal flora disorder and the like.

This application relates to the field of functional composition technology, and in particular to a GABA-vitamin D neuroprotective composition and its preparation method, comprising medium-chain triglycerides, modified phospholipids, and a GABA-vitamin D blend. This application utilizes the low interfacial tension and strong amphiphilic compatibility of medium-chain triglycerides and modified phospholipids, enabling them to be miscible with the blend, thus improving the characteristics of GABA and vitamin D being easily degraded and oxidatively inactivated under complex physiological environments, and solving the problems of poor stability and asynchronous absorption. In the preparation method, the preferred component mass ratio is (0.6–1.5):1:(1–1.6), and mixing is carried out at 50–80°C for 10–60 min. The resulting system features high encapsulation efficiency, uniform particle size distribution, and high bioavailability. After treatment in simulated gastric fluid (pH 1.2) for 2 hours, the average GABA retention rate is ≥88% (optimal up to 94.3%), and the average vitamin D retention rate is ≥94% (optimal up to 96.8%). After treatment in simulated intestinal fluid (pH 6.8) for 4 hours, the simultaneous release rate of GABA and vitamin D is ≥90%, achieving precise intestinal delivery and making it suitable for industrial production.

The invention relates to a microbial single-cell gelation encapsulation method based on aloe gel and application, the method realizes single-cell gelation encapsulation through electrostatic interaction of sterile aloe gel and intestinal anaerobic bacteria (such as Agathobacter rectasis), and the method comprises the specific steps of aloe gel preparation, bacterial suspension culture and oscillation mixing to form a stable structure. The preparation method has the advantages that the acid resistance and biocompatibility of the natural aloe gel are utilized to replace a traditional synthetic material, so that the gastrointestinal tolerance of thalli is improved; meanwhile, the synergistic effect of aloe active ingredients (such as aloe-emodin) and intestinal bacterial metabolites (butyric acid) is combined, so that the anti-inflammatory and intestinal steady-state regulation and control effects are enhanced. Experiments show that the survival rate of the encapsulated bacteria in simulated gastric juice within 4 hours is larger than or equal to 90%, the intestinal colonization rate is effectively increased compared with naked bacteria, the inflammatory factor level of a colitis model mouse can be remarkably reduced, and a safe and efficient new strategy is provided for micro-ecological treatment of inflammatory bowel diseases.

The present invention relates to the field of microbial technology, and provides a Pediococcus acidilactici YYS-J2 that can degrade acrylamide and produce high levels of phenyllactic acid, and its application. Pediococcus acidilactici The preservation number of YYS-J2 is CGMCC No. 28183. This *Pediococcus lactis* YYS-J2 exhibits excellent acrylamide removal capacity, high efficiency in L-phenylalanine utilization and metabolism, high-quality phenyllactic acid production capacity, and excellent *Streptococcus mutans* antibacterial activity. It also produces superoxide dismutase (SOD) and shows good tolerance in simulated gastric and intestinal fluids. This *Pediococcus lactis* YYS-J2 can provide a new probiotic source for the development of functional products such as acrylamide removal products, antibacterial products, and SOD-producing products, and has significant application value.

The invention discloses a composite particle with a prebiotic function and colon-targeted co-delivery performance as well as a preparation method and application thereof, and belongs to the technical field of functional foods and intestinal micro-ecological regulators. According to the composite particle, the curcumin and the resveratrol are encapsulated by the peanut protein isolate to form a nano core, the outer layer of the nano core is a composite shell layer composed of the carboxymethyl konjac glucomannan and the prebiotics, a stable core-shell structure is formed, and the composite particle is small in particle size, good in dispersity and stability and good in stability. The stability of a protein-based delivery system in a gastrointestinal tract environment can be obviously improved; the release rate of the composite particles in simulated gastric juice and intestinal juice is low, and the composite particles can be specifically degraded and release active ingredients in simulated colon fluid containing beta-mannase, so that colon-targeted co-delivery can be realized. The composite particle disclosed by the invention is simple in preparation process and stable in function, can be applied to the fields of functional foods, health foods, formula foods for special medical purposes and the like, realizes dual purposes of active component delivery and intestinal microenvironment regulation, and has a wide application prospect.

The invention relates to a colon-targeted micro-ecological regulation composition. The colon-targeted micro-ecological regulation composition is prepared by compounding the following functional components in percentage by weight: 5-95% of a component A, 1-15% of a component B and 4-94% of a component C, the component A is resistant starch, the polymerization degree DP is greater than or equal to 15, and the crystallinity is greater than or equal to 35%; the component B is probiotics and is embedded through a complex coacervation method or an extrusion-gel method, the embedding rate is larger than or equal to 75%, and the particle size is 200-800 microns; the survival rate is greater than or equal to 60% after treatment in simulated gastric juice for 2 hours, and the survival rate is greater than or equal to 50% after treatment in simulated intestinal juice for 4 hours; the component C comprises functional nutritional auxiliary materials, the functional nutritional auxiliary materials comprise prebiotics and a medicinal and edible composition, and the prebiotics comprise rapid fermentation type prebiotics, medium-speed fermentation type prebiotics, slow fermentation type prebiotics and a non-fermentation type water-holding expansion component. By constructing a carbon source slow release-flora orientation-metabolism regulation ternary interaction collaborative network, accurate regulation and multi-target metabolism intervention of the whole digestive tract are realized.

This invention discloses a selenium-enriched dairy product from selenium-enriched dairy cows and its preparation method, comprising the following components and process characteristics: Basic milk matrix: by mass percentage, containing 85-95% raw milk or reconstituted milk, 0.5-2% milk protein concentrate, and 0.1-0.5% fructooligosaccharides; Probiotic-polyphenol complex: composed of *Lactobacillus plantarum* LP-33 (preservation number CGMCC No. 24567) and grape seed polyphenols, wherein the polyphenols are compounded in a 1:1 ratio with zein-chitosan bilayer microencapsulated form in a free state, with a total addition amount of 50-100 mg / L; Dynamic pH control system: during fermentation, the pH value is monitored in real time and a 0.1-0.5 mol / L sodium bicarbonate buffer solution is automatically added to maintain the pH at 5.0-5.5. This invention achieves breakthroughs in viable count and acid resistance; through dynamic pH control and synergistic protection by polyphenols, the viable count of the finished product is ≥1×10⁻⁶. 9 With a CFU / mL concentration, the survival rate of probiotics in simulated gastric juice for 2 hours is >80%, solving the problem of "high output but low intake" of probiotics in traditional fermentation.

The invention relates to the technical field of medical instruments, in particular to a portable multi-channel glottis cover. Comprising an external cylinder, the external cylinder is fixedly connected with an air guide pipe, the external cylinder is fixedly connected with a flow guide pipe, the flow guide pipe is fixedly connected with an inflator pump, and the inflator pump is provided with a flow blocking unit; the flow blocking unit comprises first protruding rings distributed at intervals, the first protruding rings distributed at intervals are communicated with the inflator pump, and the inflator pump is communicated with second protruding rings distributed at intervals. Through the shape design and staggered arrangement of the first convex rings and the second convex rings, a plurality of annular cavities with opposite volume changes are formed in cooperation with the esophagus of a patient, when the first convex rings and the second convex rings are extruded by reflux gastric juice, the directions of counter-acting force provided by the adjacent annular cavities after the adjacent annular cavities are pressed are different, and the counter-acting force is uniform. The counter-acting force in different directions can effectively disperse external force, the deformation quantity of the first convex ring and the second convex ring is reduced, and therefore the probability of sealing failure is reduced.

The present invention discloses a magnetically guided sampling capsule robot and a sampling method, which relate to the technical field of capsule robots. A first capsule shell and a second capsule shell interlock to form an internal cavity. An internal magnet is located in the internal cavity. A first soft magnetic film and a second soft magnetic film are located on either side of the internal magnet. In the absence of an external magnetic field, the first soft magnetic film and the second soft magnetic film both protrude toward the internal magnet. A first sampling hole is provided on the first capsule shell, forming a first sampling cavity between the first capsule shell and the first soft magnetic film. A second sampling hole is provided on the second capsule shell, forming a second sampling cavity between the second capsule shell and the second soft magnetic film. The present invention is used for sampling gastric fluid and / or mucosa at a lesion site, can achieve anchored sampling under the action of an external magnetic field, and can achieve a single gastric entry and multiple sampling operations through the design of the symmetrically arranged first and second sampling cavities.

The invention relates to a separation type critical patient liquid diet feeding device which comprises a main box body, a first storage cavity and a second storage cavity are formed in the main box body, a connecting base and a Y-shaped three-way pipe are installed outside the main box body, and a first pipe cavity and a second pipe cavity are formed in the connecting base. One end of the first tube cavity and one end of the second tube cavity are communicated with two branch tubes of the Y-shaped three-way tube respectively, the other end of the first tube cavity and the other end of the second tube cavity are communicated with the first storage cavity and the second storage cavity respectively, and a main tube of the Y-shaped three-way tube is connected with a stomach tube communicated with the stomach led into a patient. An opening and closing piece used for adjusting the first pipe cavity and the second pipe cavity to be closed or opened is movably installed in the connecting base, pushing pressure is generated in the first storage cavity, so that liquid food is conveyed, liquid food feeding operation of a patient is facilitated, meanwhile, regurgitated gastric juice of the patient is conveniently pumped into the second storage cavity, and the patient can conveniently feed the liquid food. And the first storage cavity and the second storage cavity do not interfere with each other under the action of the opening and closing piece, so that pollution caused by liquid food storage is avoided.

The utility model relates to the field of medical instruments, and discloses a nasal gastrointestinal tube multifunctional connector which comprises a connector body, a one-way valve is arranged at the top end of the connector body, a nutrition catheter is fixedly connected to the bottom end of the connector body, a liquid extraction gastral cavity is fixedly connected to one side of the connector body, and the liquid extraction gastral cavity is fixedly connected to the other side of the connector body. The other side of the connector body is fixedly connected with a nutrition enteric cavity, the outer wall of the nutrition catheter is provided with an external thread, the outer wall of the external thread is in threaded connection with a threaded sleeve, the outer wall of the threaded sleeve is provided with an elastic band, and the outer wall of the elastic band is fixedly connected with a first fixing piece. According to the utility model, by arranging the structures such as the external thread, the threaded sleeve, the elastic band, the fixing piece I and the fixing piece II, the connector can be adjusted and fixed beside the body of a user according to the operation convenience of a worker, so that the stability of the connector main body when gastric juice is sucked and nutrient solution is conveyed to the intestinal tract is ensured, and the stability and the safety of a pipeline are ensured.

The present invention relates to compositions in the form of cationic microemulsion preconcentrates that contain at least one lipophilic and water-insoluble active agent, at least one polyglyceryl-containing emulsifier, at least one cationic emulsifier, carrier oils, solubilizers, antioxidants, and preservatives. When contacted with either an aqueous medium, gastric or intestinal fluid, the cationic microemulsion preconcentrates self-assemble into cationic microemulsions that are stable in gastric and intestinal fluids. The invention is also related to methods of making and methods of using the cationic microemulsion preconcentrates.

The utility model relates to the technical field of gastroenterology department, in particular to a pressurized gastric lavage device for emergency gastroenterology department, which is provided with an independent detachable dirt storage barrel structure and is combined with a gastric lavage mechanism to form a single pipeline, so that the pressurized gastric lavage device is more portable and efficient to clean, and the practicability is improved; comprising a base, a connecting frame, a water bath mechanism, a gastric lavage liquid storage barrel, a first external thread opening, a first internal thread cover, a pressure pump, a pressure pipe, a pressure reduction pump, an air suction pipe, a second internal thread cover, a dirt storage barrel, a second external thread opening and a grip, the middle of the top end of the base is connected with the bottom end of the connecting frame, and the top end of the connecting frame is connected with the pressure pump and the pressure reduction pump; the bottom end in the connecting frame is connected with the top end of a second internal thread cover, the inner side of the second internal thread cover is detachably screwed with the outer side of a second external thread opening, the bottom end of the second external thread opening is connected with the top end of a dirt storage barrel, the middle of one side of the outer end of the dirt storage barrel is connected with the inner side of a grip, and a gastric lavage tube structure is arranged on the outer sides of the gastric lavage liquid storage barrel and the second internal thread cover.

The preparation method comprises the following steps: (1) compounding hermetia illucens larvae, whole tenebrio molitor and euphausia superba according to a mass ratio of (3-5): (2-4): 1, carrying out enzymolysis, and reacting with a yeast cell wall extract to form a glycopeptide compound; (2) coating the glycopeptide compound with a mannan oligosaccharide and chitosan solution to form microcapsules, and controlling the release rate of the microcapsules in simulated gastric juice to be lower than 30% and the release rate of the microcapsules in simulated intestinal juice to be higher than 80%; (3) co-fermenting the microcapsules, clostridium butyricum and pediococcus acidilactici, and adsorbing fermentation liquor on the porous starch; (4) performing dry mixing on the functional compound, the fermentation compound and the base material, and performing low-temperature puffing; and (5) sequentially spraying a vitamin D3 grease layer, a pectin-whey protein protective layer and a solution containing TGF-beta2 on the surfaces of the particles. Through cooperation of multiple processes, the immune function and intestinal health of pets are remarkably improved, and the product is good in stability and palatability.

This invention discloses a method for evaluating the bioavailability of soybean oil based on an in vitro digestion / cell co-culture model. Soybean oil is emulsified using WPI emulsifier and then digested sequentially through simulated gastric and intestinal fluids to obtain the gastric digestion products of soybean oil. Fatty acids are extracted from the intestinal digestion products of soybean oil, dissolved in dimethyl sulfoxide, and linked to fatty acid-free bovine serum albumin to obtain in vitro digestion products of soybean oil that can be absorbed by the intestines. These are then added to a cell co-culture model for cell incubation and transport. HepG2 cells from the cell co-culture model are collected, and Oil Red O staining and total triglyceride content are measured to obtain lipid deposition, thereby evaluating the bioavailability of soybean oil. The in vitro digestion / cell co-culture model of this invention is specifically designed for soybean oil digestion. This method objectively and scientifically evaluates the bioavailability of soybean oil at different metabolic stages, providing a standard basis for the scientific and healthy consumption of soybean oil and possessing significant practical value.

The utility model discloses a portable camel rumen fluid extraction device, relates to the technical field of gastric fluid extraction, and mainly aims to provide equipment suitable for camel gastric fluid extraction. According to the main technical scheme, the portable camel rumen fluid extraction device comprises a tube body and a suction part, the pipe body comprises a hose and a spring, the hose is sleeved with the spring, one end of the spring is connected to an olive head, the olive head is nested in a soft rubber sleeve, one end of the hose is connected to a plugging piece, the plugging piece is arranged in the olive head, and a feeding port is formed in the side wall of one end of the hose; and the suction part is detachably connected to the other end of the hose.

This invention relates to the field of gastric residual volume detection technology, specifically a Bluetooth transmission device for ultrasound monitoring of gastric residual volume during enteral nutrition for infants and young children. The device includes a main body structure and a transmission device-mounted control system. The control system includes an ultrasound signal acquisition module, a signal processing module, a Bluetooth transmission module, a residual volume calculation module, and a graded alarm module. This invention achieves this by selecting a target frequency band to match the acoustic impedance characteristics of gastric fluid, dynamically tuning the probe's transmission power based on abdominal wall thickness to reduce gas and tissue interference and improve signal accuracy. It corrects signal mapping deviations based on a three-dimensional gastric cavity model, compensates for postural shifts, generates a gastric fluid distribution model to enhance accuracy, dynamically segments data packets and embeds time-series tags to ensure complete transmission and anti-interference capabilities, combines intake rate and gastric emptying curve correction parameters to quantify volume and compensate for errors, improving calculation reliability, and generating graded alarm commands to link with clinical operations.

The present application relates to the field of food technology, in particular to a natural pectin composition suitable for weight loss population and its preparation method and application. The natural pectin composition comprises: fructus pruni naturalis gum powder and chia seed gum powder, and the mass ratio of the fructus pruni naturalis gum powder and the chia seed gum powder is 1:0.05-1. In the present application, the fructus pruni naturalis gum powder and the chia seed gum powder are compounded according to the defined ratio, and after adding water, a low-calorie gel food with satiety is obtained. The gel food has high gel strength, good taste and good swelling performance in the stomach, so it stays in the simulated gastric juice environment for a long time, has good satiety, helps to reduce the hunger of the weight loss population, thereby helps to control the food intake, and further achieves the effect of weight loss.

The invention provides a roxburgh rose source intelligent delivery system and a preparation method and application thereof. The system is formed by self-assembling roxburgh rose endogenous components through physical field programming induction, and simultaneously meets the following requirements: (1) the molar ratio of Cu < 2 + > to Mn < 2 + > is (1: 5.5)-(1: 6.5), and the molar ratio of Cu < 2 + > to Sr < 2 + > is (1: 0.45)-(1: 0.51); (2) the Zeta potential is-5 mV to + 5 mV, and the conductivity is lt; 10 S / cm; (3) a release rate lt in simulated gastric juice; the release rate gt in simulated intestinal juice within 2 hours is 10%; 80%; and (4) in terms of solids, single administration MTD is greater than or equal to 5.0 g / kg. The system has nearly neutral Zeta potential and extremely low conductivity, keeps stable in long-term storage, can synergistically reduce serum uric acid, transaminase and blood sugar, and has a kidney protection effect while efficiently reducing uric acid. The invention further provides a green preparation method of the system and multi-field application of the system.

The invention relates to the technical field of microorganisms, in particular to lactobacillus reuteri with antibiotic post-effect prevention and control and Chinese herbal medicine synergistic interaction functions, the lactobacillus reuteri is named as HBNK11 and is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC M20251479. The lactobacillus reuteri provided by the invention has a remarkable inhibition effect on gram-positive bacteria and gram-negative bacteria, and breaks through the limitation of narrow antibacterial spectrum of traditional probiotics. Meanwhile, the survival rate in simulated gastric juice with the pH value of 2.5 reaches 112.4%, it is ensured that the strain stably survives and plays a role in the strong acid environment of the gastrointestinal tract of livestock and poultry, and the problem that the gastrointestinal tract tolerance of traditional probiotics is poor is solved. When the lactobacillus reuteri is coordinated with a Chinese herbal medicine monomer, the monomer dosage can be reduced by 128 times. The lactobacillus reuteri provides a high-quality resource for developing a novel microbial feed additive, and has important application value for reducing antibiotic dependence in a breeding link and preventing and controlling propagation of multiple drug-resistant bacteria.

This invention relates to a gastric drug delivery system based on biomechanically responsive intelligent deformation and anchoring, and its preparation method. The system includes a main body, multiple microneedle structures, a drug-loading unit, and a controlled-release unit. The main body is made of a thermoresponsive shape memory polymer and includes a head and multiple tentacles. The head is spherical with an opening, and the tentacles are distributed around the opening. Multiple microneedle structures are disposed on the tentacles. The drug-loading unit contains a metal-organic framework carrier and a drug, with the drug loaded on the metal-organic framework carrier. The drug-loading unit is distributed in the main body and / or multiple microneedle structures. When a triggering factor occurs, the drug-loading unit releases the drug. The controlled-release unit is used to control the release rate of the drug in the drug-loading unit. The main body structure of this invention utilizes the shape-restoring force generated by thermo-induced mechanical deformation to achieve stable buoyancy and fluid obstruction in gastric juice. The microneedle structures anchor to the gastric wall, effectively counteracting mechanical displacement caused by gastric peristalsis, enabling precise on-demand drug delivery.

The invention discloses lactobacillus rhamnosus and application thereof, the lactobacillus rhamnosus is named as lactobacillus rhamnosus, the preservation number of the lactobacillus rhamnosus is CGMCC (China General Microbiological Culture Collection Center) No.35978, and the lactobacillus rhamnosus is preserved in the China General Microbiological Culture Collection Center on September 18, 2025. The strain has excellent alcohol tolerance and can survive in a 15% ethanol environment, and the degradation rate of the strain to a 10% ethanol solution in vitro reaches 17% or above; meanwhile, the strain has outstanding gastrointestinal fluid tolerance, and the survival rate of the strain treated in simulated gastric fluid with the pH value of 2.5 for 2 hours exceeds 93%. The strain and the fermentation product thereof also show remarkable antioxidant activity, and can effectively remove DPPH free radicals. The invention further provides application of the bacterial strain in preparation of products for dispelling effects of alcohol, protecting liver and resisting oxidation, and fermentation liquor, bacterial suspension and related compositions containing the bacterial strain, and the bacterial strain can be widely applied to the fields of functional foods, medicines and health-care products.

The present application relates to the field of bionics, and in particular to a liposome in-vitro digestion simulation method based on the digestive physiological characteristics of infants and young children. Based on the digestive physiological characteristics of infants and young children in the early life, BSSL and PLRP2 are used in the simulation process, so that the simulation environment is more realistic, and the simulation effect is improved. The fitting degree of the method of the present application to the in-vivo lipid digestion conditions of infants and young children is improved by 30-50% compared with the prior art. By dynamically regulating the simulated gastric juice secretion rate, the simulated intestinal juice secretion rate, the acid liquid secretion rate, the alkaline liquid secretion rate, the mechanical parameters and the enzyme kinetic parameters, high-precision fitting of the digestive environment characteristics of infants and young children after feeding is achieved. The present application first realizes the system integration of special digestive enzymes and dynamic physiological parameters of infants and young children, and provides a high-bionic standardized scheme for the evaluation of the lipid digestion characteristics of infant formula food.

1. Name of the product of this design: Exosome purification equipment (small). 2. Purpose of the product of this design: used for filtration, for extracting proteins, cells, bacteria, exosomes, circulating tumor cells and other substances from biological samples such as cell culture fluid, bacterial culture fluid, human plasma, serum, cerebrospinal fluid, saliva, urine and gastric juice. 3. The key design point of this design product lies in the combination of product shape and pattern. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.