43 results about "Gastric fluid" patented technology

The invention provides a pet hair decomposer with synergistic effect of bacillus subtilis and keratinase, the pet hair decomposer comprises bacillus subtilis ZYpet-015 and keratinase, the preservation number of the bacillus subtilis ZYpet-015 is CGMCC (China General Microbiological Culture Collection Center) No.34790, and the preservation date is June 6, 2025; the protease activity of the bacillus subtilis is greater than or equal to 129.92 U, the survival rate of the bacillus subtilis in simulated gastric juice within 3 hours is greater than 50%, and the tolerance rate of the bacillus subtilis in intestinal juice within 4 hours is greater than 90%. According to the pet hair decomposing agent, hair keratin is synergistically degraded through protease secreted by the bacillus subtilis ZYpet-015 and keratinase, and the hair decomposing efficiency reaches 28.07% + / -2.79% and is remarkably higher than that of a single treatment group. Meanwhile, experiments prove that the pet hair decomposer can effectively destroy the hair cuticle structure, is suitable for a pet hair-melting nutritional supplement and can relieve the hair ball symptom.

This application relates to the field of functional composition technology, and in particular to a GABA-vitamin D neuroprotective composition and its preparation method, comprising medium-chain triglycerides, modified phospholipids, and a GABA-vitamin D blend. This application utilizes the low interfacial tension and strong amphiphilic compatibility of medium-chain triglycerides and modified phospholipids, enabling them to be miscible with the blend, thus improving the characteristics of GABA and vitamin D being easily degraded and oxidatively inactivated under complex physiological environments, and solving the problems of poor stability and asynchronous absorption. In the preparation method, the preferred component mass ratio is (0.6–1.5):1:(1–1.6), and mixing is carried out at 50–80°C for 10–60 min. The resulting system features high encapsulation efficiency, uniform particle size distribution, and high bioavailability. After treatment in simulated gastric fluid (pH 1.2) for 2 hours, the average GABA retention rate is ≥88% (optimal up to 94.3%), and the average vitamin D retention rate is ≥94% (optimal up to 96.8%). After treatment in simulated intestinal fluid (pH 6.8) for 4 hours, the simultaneous release rate of GABA and vitamin D is ≥90%, achieving precise intestinal delivery and making it suitable for industrial production.

The invention relates to a microbial single-cell gelation encapsulation method based on aloe gel and application, the method realizes single-cell gelation encapsulation through electrostatic interaction of sterile aloe gel and intestinal anaerobic bacteria (such as Agathobacter rectasis), and the method comprises the specific steps of aloe gel preparation, bacterial suspension culture and oscillation mixing to form a stable structure. The preparation method has the advantages that the acid resistance and biocompatibility of the natural aloe gel are utilized to replace a traditional synthetic material, so that the gastrointestinal tolerance of thalli is improved; meanwhile, the synergistic effect of aloe active ingredients (such as aloe-emodin) and intestinal bacterial metabolites (butyric acid) is combined, so that the anti-inflammatory and intestinal steady-state regulation and control effects are enhanced. Experiments show that the survival rate of the encapsulated bacteria in simulated gastric juice within 4 hours is larger than or equal to 90%, the intestinal colonization rate is effectively increased compared with naked bacteria, the inflammatory factor level of a colitis model mouse can be remarkably reduced, and a safe and efficient new strategy is provided for micro-ecological treatment of inflammatory bowel diseases.

The invention discloses a composite particle with a prebiotic function and colon-targeted co-delivery performance as well as a preparation method and application thereof, and belongs to the technical field of functional foods and intestinal micro-ecological regulators. According to the composite particle, the curcumin and the resveratrol are encapsulated by the peanut protein isolate to form a nano core, the outer layer of the nano core is a composite shell layer composed of the carboxymethyl konjac glucomannan and the prebiotics, a stable core-shell structure is formed, and the composite particle is small in particle size, good in dispersity and stability and good in stability. The stability of a protein-based delivery system in a gastrointestinal tract environment can be obviously improved; the release rate of the composite particles in simulated gastric juice and intestinal juice is low, and the composite particles can be specifically degraded and release active ingredients in simulated colon fluid containing beta-mannase, so that colon-targeted co-delivery can be realized. The composite particle disclosed by the invention is simple in preparation process and stable in function, can be applied to the fields of functional foods, health foods, formula foods for special medical purposes and the like, realizes dual purposes of active component delivery and intestinal microenvironment regulation, and has a wide application prospect.

The invention relates to a colon-targeted micro-ecological regulation composition. The colon-targeted micro-ecological regulation composition is prepared by compounding the following functional components in percentage by weight: 5-95% of a component A, 1-15% of a component B and 4-94% of a component C, the component A is resistant starch, the polymerization degree DP is greater than or equal to 15, and the crystallinity is greater than or equal to 35%; the component B is probiotics and is embedded through a complex coacervation method or an extrusion-gel method, the embedding rate is larger than or equal to 75%, and the particle size is 200-800 microns; the survival rate is greater than or equal to 60% after treatment in simulated gastric juice for 2 hours, and the survival rate is greater than or equal to 50% after treatment in simulated intestinal juice for 4 hours; the component C comprises functional nutritional auxiliary materials, the functional nutritional auxiliary materials comprise prebiotics and a medicinal and edible composition, and the prebiotics comprise rapid fermentation type prebiotics, medium-speed fermentation type prebiotics, slow fermentation type prebiotics and a non-fermentation type water-holding expansion component. By constructing a carbon source slow release-flora orientation-metabolism regulation ternary interaction collaborative network, accurate regulation and multi-target metabolism intervention of the whole digestive tract are realized.

This invention discloses a selenium-enriched dairy product from selenium-enriched dairy cows and its preparation method, comprising the following components and process characteristics: Basic milk matrix: by mass percentage, containing 85-95% raw milk or reconstituted milk, 0.5-2% milk protein concentrate, and 0.1-0.5% fructooligosaccharides; Probiotic-polyphenol complex: composed of *Lactobacillus plantarum* LP-33 (preservation number CGMCC No. 24567) and grape seed polyphenols, wherein the polyphenols are compounded in a 1:1 ratio with zein-chitosan bilayer microencapsulated form in a free state, with a total addition amount of 50-100 mg / L; Dynamic pH control system: during fermentation, the pH value is monitored in real time and a 0.1-0.5 mol / L sodium bicarbonate buffer solution is automatically added to maintain the pH at 5.0-5.5. This invention achieves breakthroughs in viable count and acid resistance; through dynamic pH control and synergistic protection by polyphenols, the viable count of the finished product is ≥1×10⁻⁶. 9 With a CFU / mL concentration, the survival rate of probiotics in simulated gastric juice for 2 hours is >80%, solving the problem of "high output but low intake" of probiotics in traditional fermentation.

The utility model relates to the technical field of gastroenterology department, in particular to a pressurized gastric lavage device for emergency gastroenterology department, which is provided with an independent detachable dirt storage barrel structure and is combined with a gastric lavage mechanism to form a single pipeline, so that the pressurized gastric lavage device is more portable and efficient to clean, and the practicability is improved; comprising a base, a connecting frame, a water bath mechanism, a gastric lavage liquid storage barrel, a first external thread opening, a first internal thread cover, a pressure pump, a pressure pipe, a pressure reduction pump, an air suction pipe, a second internal thread cover, a dirt storage barrel, a second external thread opening and a grip, the middle of the top end of the base is connected with the bottom end of the connecting frame, and the top end of the connecting frame is connected with the pressure pump and the pressure reduction pump; the bottom end in the connecting frame is connected with the top end of a second internal thread cover, the inner side of the second internal thread cover is detachably screwed with the outer side of a second external thread opening, the bottom end of the second external thread opening is connected with the top end of a dirt storage barrel, the middle of one side of the outer end of the dirt storage barrel is connected with the inner side of a grip, and a gastric lavage tube structure is arranged on the outer sides of the gastric lavage liquid storage barrel and the second internal thread cover.

The preparation method comprises the following steps: (1) compounding hermetia illucens larvae, whole tenebrio molitor and euphausia superba according to a mass ratio of (3-5): (2-4): 1, carrying out enzymolysis, and reacting with a yeast cell wall extract to form a glycopeptide compound; (2) coating the glycopeptide compound with a mannan oligosaccharide and chitosan solution to form microcapsules, and controlling the release rate of the microcapsules in simulated gastric juice to be lower than 30% and the release rate of the microcapsules in simulated intestinal juice to be higher than 80%; (3) co-fermenting the microcapsules, clostridium butyricum and pediococcus acidilactici, and adsorbing fermentation liquor on the porous starch; (4) performing dry mixing on the functional compound, the fermentation compound and the base material, and performing low-temperature puffing; and (5) sequentially spraying a vitamin D3 grease layer, a pectin-whey protein protective layer and a solution containing TGF-beta2 on the surfaces of the particles. Through cooperation of multiple processes, the immune function and intestinal health of pets are remarkably improved, and the product is good in stability and palatability.

This invention discloses a method for evaluating the bioavailability of soybean oil based on an in vitro digestion / cell co-culture model. Soybean oil is emulsified using WPI emulsifier and then digested sequentially through simulated gastric and intestinal fluids to obtain the gastric digestion products of soybean oil. Fatty acids are extracted from the intestinal digestion products of soybean oil, dissolved in dimethyl sulfoxide, and linked to fatty acid-free bovine serum albumin to obtain in vitro digestion products of soybean oil that can be absorbed by the intestines. These are then added to a cell co-culture model for cell incubation and transport. HepG2 cells from the cell co-culture model are collected, and Oil Red O staining and total triglyceride content are measured to obtain lipid deposition, thereby evaluating the bioavailability of soybean oil. The in vitro digestion / cell co-culture model of this invention is specifically designed for soybean oil digestion. This method objectively and scientifically evaluates the bioavailability of soybean oil at different metabolic stages, providing a standard basis for the scientific and healthy consumption of soybean oil and possessing significant practical value.

This invention relates to the field of gastric residual volume detection technology, specifically a Bluetooth transmission device for ultrasound monitoring of gastric residual volume during enteral nutrition for infants and young children. The device includes a main body structure and a transmission device-mounted control system. The control system includes an ultrasound signal acquisition module, a signal processing module, a Bluetooth transmission module, a residual volume calculation module, and a graded alarm module. This invention achieves this by selecting a target frequency band to match the acoustic impedance characteristics of gastric fluid, dynamically tuning the probe's transmission power based on abdominal wall thickness to reduce gas and tissue interference and improve signal accuracy. It corrects signal mapping deviations based on a three-dimensional gastric cavity model, compensates for postural shifts, generates a gastric fluid distribution model to enhance accuracy, dynamically segments data packets and embeds time-series tags to ensure complete transmission and anti-interference capabilities, combines intake rate and gastric emptying curve correction parameters to quantify volume and compensate for errors, improving calculation reliability, and generating graded alarm commands to link with clinical operations.

The present application relates to the field of food technology, in particular to a natural pectin composition suitable for weight loss population and its preparation method and application. The natural pectin composition comprises: fructus pruni naturalis gum powder and chia seed gum powder, and the mass ratio of the fructus pruni naturalis gum powder and the chia seed gum powder is 1:0.05-1. In the present application, the fructus pruni naturalis gum powder and the chia seed gum powder are compounded according to the defined ratio, and after adding water, a low-calorie gel food with satiety is obtained. The gel food has high gel strength, good taste and good swelling performance in the stomach, so it stays in the simulated gastric juice environment for a long time, has good satiety, helps to reduce the hunger of the weight loss population, thereby helps to control the food intake, and further achieves the effect of weight loss.

The invention provides a roxburgh rose source intelligent delivery system and a preparation method and application thereof. The system is formed by self-assembling roxburgh rose endogenous components through physical field programming induction, and simultaneously meets the following requirements: (1) the molar ratio of Cu < 2 + > to Mn < 2 + > is (1: 5.5)-(1: 6.5), and the molar ratio of Cu < 2 + > to Sr < 2 + > is (1: 0.45)-(1: 0.51); (2) the Zeta potential is-5 mV to + 5 mV, and the conductivity is lt; 10 S / cm; (3) a release rate lt in simulated gastric juice; the release rate gt in simulated intestinal juice within 2 hours is 10%; 80%; and (4) in terms of solids, single administration MTD is greater than or equal to 5.0 g / kg. The system has nearly neutral Zeta potential and extremely low conductivity, keeps stable in long-term storage, can synergistically reduce serum uric acid, transaminase and blood sugar, and has a kidney protection effect while efficiently reducing uric acid. The invention further provides a green preparation method of the system and multi-field application of the system.

This invention relates to a gastric drug delivery system based on biomechanically responsive intelligent deformation and anchoring, and its preparation method. The system includes a main body, multiple microneedle structures, a drug-loading unit, and a controlled-release unit. The main body is made of a thermoresponsive shape memory polymer and includes a head and multiple tentacles. The head is spherical with an opening, and the tentacles are distributed around the opening. Multiple microneedle structures are disposed on the tentacles. The drug-loading unit contains a metal-organic framework carrier and a drug, with the drug loaded on the metal-organic framework carrier. The drug-loading unit is distributed in the main body and / or multiple microneedle structures. When a triggering factor occurs, the drug-loading unit releases the drug. The controlled-release unit is used to control the release rate of the drug in the drug-loading unit. The main body structure of this invention utilizes the shape-restoring force generated by thermo-induced mechanical deformation to achieve stable buoyancy and fluid obstruction in gastric juice. The microneedle structures anchor to the gastric wall, effectively counteracting mechanical displacement caused by gastric peristalsis, enabling precise on-demand drug delivery.

The invention discloses lactobacillus rhamnosus and application thereof, the lactobacillus rhamnosus is named as lactobacillus rhamnosus, the preservation number of the lactobacillus rhamnosus is CGMCC (China General Microbiological Culture Collection Center) No.35978, and the lactobacillus rhamnosus is preserved in the China General Microbiological Culture Collection Center on September 18, 2025. The strain has excellent alcohol tolerance and can survive in a 15% ethanol environment, and the degradation rate of the strain to a 10% ethanol solution in vitro reaches 17% or above; meanwhile, the strain has outstanding gastrointestinal fluid tolerance, and the survival rate of the strain treated in simulated gastric fluid with the pH value of 2.5 for 2 hours exceeds 93%. The strain and the fermentation product thereof also show remarkable antioxidant activity, and can effectively remove DPPH free radicals. The invention further provides application of the bacterial strain in preparation of products for dispelling effects of alcohol, protecting liver and resisting oxidation, and fermentation liquor, bacterial suspension and related compositions containing the bacterial strain, and the bacterial strain can be widely applied to the fields of functional foods, medicines and health-care products.

The invention provides a coenzyme Q10 enteric capsule as well as a preparation method and application thereof, and belongs to the technical field of preparation of pharmaceutical preparations. The coenzyme Q10 enteric capsule provided by the invention is prepared from coenzyme Q10, olive oil, carnauba wax, vitamin E and an enteric coating material. The coenzyme Q10 enteric capsule provided by the invention can effectively protect the coenzyme Q10 from being damaged by gastric acid and can be quickly released in intestinal tracts, so that the bioavailability of the medicine is remarkably improved. In-vitro dissolution experiments show that the release rate of the coenzyme Q10 enteric capsule in simulated gastric juice within 2 hours is lower than 10%, and the release rate of the coenzyme Q10 enteric capsule in simulated intestinal juice within 30 minutes is higher than 80%. Cell experiments prove that the coenzyme Q10 enteric capsule provided by the invention is good in biocompatibility and free of remarkable cytotoxicity. Animal pharmacokinetic experiments show that the plasma peak concentration and bioavailability of the coenzyme Q10 enteric capsule provided by the invention are obviously higher than those of commercially available soft capsules and tablets.

This invention relates to the field of medical device technology and discloses a gastric lavage device for emergency internal medicine, including a base, a main control box mounted on the base, a gastric lavage fluid supply module, a negative pressure suction module, and a double-lumen gastric tube. The main control box is equipped with a temperature control module and a display panel. The gastric lavage fluid supply module includes a gastric lavage fluid container and an inlet pump located within the main control box, with the inlet of the inlet pump connected to the gastric lavage fluid container. The negative pressure suction module includes a waste collection tank and a negative pressure suction pump located within the main control box, with the outlet of the negative pressure suction pump connected to the waste collection tank. The double-lumen gastric tube includes an inner tube and an outer tube arranged coaxially. The inner tube forms an outlet channel, and the annular gap between the inner and outer tubes forms an inlet channel. Several rinsing side holes are circumferentially formed on the side wall of the outer tube near its front end. This invention improves the safety, stability, and convenience of emergency gastric lavage through intelligent pressure control, closed-loop constant temperature, anti-bite and anti-detachment design, and a clean / dirty separation structure.

The invention belongs to the field of food microencapsulation and freeze-drying preparation, and discloses probiotic microencapsulated freeze-dried powder and a preparation method thereof.The microcapsule is of a three-layer cascade controlled-release structure, and the outer layer is resistant to acid and gastric juice erosion; opening the middle intestine, and realizing segmented release from the small intestine to the colon through an enzyme triggering mechanism; a high-hydrophilic nanofiber net is formed on the inner layer, so that a slow-release function is realized; hyaluronic acid oligosaccharide is adopted as a freeze-drying protective agent to form a'hydrated nano-net ', so that ice crystal damage is remarkably reduced, and the survival rate of thalli is increased; the preparation method comprises the steps of bacterial liquid pretreatment, micro-fluidic spray forming, segmented cross-linking and partitioned drying, and an efficient and energy-saving production process is realized in combination with a gradient heating freeze-drying process. In-vitro simulation experiments show that the freeze-dried powder has excellent survival performance in simulated gastric juice, can release viable bacteria in an intestinal environment according to a planned sequence, and has excellent long-term storage stability.

The invention discloses a berberine hydrochloride colon-targeted preparation, a preparation method thereof and application of the berberine hydrochloride colon-targeted preparation in treatment of type 2 diabetes mellitus, and belongs to the field of medicines, and berberine hydrochloride colon-targeted pellets are prepared through extrusion rolling and fluidized bed coating technologies. In-vitro test results show that the accumulative release rate of the preparation in simulated gastric juice, duodenal juice and intestinal juice within 2 hours is less than 10%; and when being transferred into simulated colon liquid (pH 7.6), the 2-hour accumulative release rate is greater than 60%, and the 4-hour accumulative release rate is greater than 80%, so that colon-targeted drug delivery can be realized, and the preparation is simple and convenient. The preparation can effectively control the blood sugar level of diabetic mice, regulate the blood fat level and improve the glucose tolerance, and more medicine choices are provided for treatment of type 2 diabetes mellitus.

The present application relates to the technical field of gastric lavage machine, and disclose a nursing gastric lavage machine for preventing reflux of comatose patients with gastric tube lavage. The chamber of the buffer tank is in pressure communication with the dirty liquid tank through the communication pipe, and the inside is provided with a piston plate pushed by a spring; the buffer tank is provided with a first flow channel and a second flow channel in communication with the gastric lavage liquid tank respectively; the gastric tube assembly is provided with corresponding first and second lavage channels and suction channels; the adjusting mechanism is linked with the piston plate, when the suction circuit is blocked and the negative pressure of the dirty liquid tank is abnormally increased, the piston plate is pressed to move to the trigger position, driving the adjusting mechanism to execute three actions simultaneously: cutting off the first flow channel, turning on the second flow channel, and blocking the suction circuit; so as to automatically flush the lavage liquid to the blockage of the pipe head, and prevent reflux during treatment; the present application realizes automatic detection, rapid dredging and system reset of blockage, and significantly improves the safety, continuity and nursing efficiency of gastric lavage operation of comatose patients.

The invention relates to the field of stomach tube anti-pulling, in particular to a stomach tube anti-pulling device which comprises a body, a rotating body and two anti-pulling auxiliary dredging mechanisms, and the rotating body is rotationally connected with the body; each anti-pulling auxiliary dredging mechanism comprises an anti-pulling unit, an auxiliary dredging unit and two meshed gears, each anti-pulling unit comprises a screw tube, a square block, a threaded tube, an anti-pulling tube and an anti-pulling block, the square blocks are in sliding connection with the supporting blocks, the screw tubes are in threaded connection with the threaded tubes, one gear is fixedly connected with the rotating body, and the other gear is fixedly connected with the screw tubes; the auxiliary dredging unit comprises an elastic rope, an auxiliary dredging rod and an auxiliary dredging block, the elastic rope is connected with one end of the auxiliary dredging rod, and the auxiliary dredging block is connected with the other end of the auxiliary dredging rod; according to the stomach tube anti-pulling method, in the rotating process of the rotating body, the two anti-pulling blocks apply pressure to the bent position of the stomach tube, and meanwhile the auxiliary through block slides out of the auxiliary through groove to apply pressure to the stomach tube before bending is completed. By the adoption of the technical scheme, smooth drainage of gastric juice is guaranteed while mistaken pulling of the stomach tube is reduced.

The invention belongs to the technical field of endoscopes, particularly relates to an intragastric double-endoscope collaborative visual diagnosis device, and aims to solve the problem that due to the fact that part of gastric diseases can be clearly diagnosed only by depending on long-time continuous observation, an existing gastroscope is difficult to meet the dynamic monitoring requirement. The capsule gastroscope comprises a capsule gastroscope body, a flexible gastroscope body and a magnetic attraction mechanism. The capsule gastroscope is internally provided with a liquid storage cavity used for containing adhesive liquid and has an auxiliary observation mode and a continuous observation mode. And the front end part of the flexible gastroscope is detachably connected to the capsule gastroscope. When the intragastric double-endoscope collaborative visual diagnosis device is used, after the flexible gastroscope conveys the capsule gastroscope to an observation position, the magnetic attraction mechanism applies magnetic attraction force to fix the capsule gastroscope to the stomach wall and trigger release of the adhesive liquid, the adhesive liquid adheres and fixes the capsule gastroscope to the stomach wall, the capsule gastroscope independently and continuously collects intragastric images, and the capsule gastroscope is used for detecting the intragastric images. And the capsule gastroscope falls off from the stomach wall until the bonding liquid loses efficacy due to the effect of gastric juice.

A pharmaceutical composition in the form of a compressed tablet for oral administration. The composition has an intragranular portion including a first porous solid carrier with a physiologically acceptable salt that is soluble in gastric fluid / an acidic aqueous media, and a self-nanoemulsifying drug delivery system (SNEDDS) adsorbed on the carrier. The SNEDDS includes: at least one cannabinoid; one or more solubilizing agents selected from physiologically acceptable organic compounds including: alcohols C8-C18, cyclic alcohols, aromatic alcohols, glycerides, polyethylene glycols, polyethylene glycol esters, aromatic esters, phenols, tocopherols, phospholipids, polyoxylglycerides, or polyoxyethylene stearates; one or more emulsifying agents selected from physiologically acceptable nonionic surfactants; and one or more carrier oils. The composition has an extragranular portion including: an optional second porous solid carrier including a physiologically acceptable salt that is soluble in gastric fluid / an acidic aqueous media; one or more disintegrants; one or more diluents; and one or more lubricants.

The invention relates to the technical field of gastric lavage machines, and discloses an anti-reflux nursing gastric lavage machine suitable for gastric tube lavage of coma patients. A cavity of a buffer tank is in pressure communication with a dirty liquid tank through a communicating pipe, and a piston plate pushed by a spring is arranged in the buffer tank; a first flow channel and a second flow channel which are respectively communicated with the gastric lavage liquid tank are arranged in the buffer tank; a first lavage channel, a second lavage channel and a suction channel which correspond to each other are arranged in the stomach tube assembly; the adjusting mechanism is linked with the piston plate, when the negative pressure of the dirty liquid tank is abnormally increased due to blockage of the suction loop, the piston plate is pressed to move to a triggering position, and the adjusting mechanism is driven to synchronously execute three actions: cutting off the first flow channel, conducting the second flow channel and blocking the suction loop; therefore, the irrigation solution automatically washes the blocked part of the pipe head, and backflow is prevented in the treatment period; according to the invention, automatic detection, rapid dredging and system resetting of blockage are realized, and the safety, continuity and nursing efficiency of gastric lavage operation of coma patients are remarkably improved.

The invention relates to the technical field of animal physiology research, and discloses a yak living gastric juice and intestinal juice sampling system and method capable of achieving segmented positioning, and the system comprises a negative pressure sampling unit, a plurality of positioning units, a physiological parameter sensing unit, a control unit and a multi-connected independent sample collection device. According to the method, real-time navigation is carried out through the sensor, the positioning unit is sequentially controlled to anchor different target parts of the digestive tract of the yak, and pure digestive juice samples are extracted respectively. The device solves the problems of inaccurate positioning, large trauma and easy sample pollution in the prior art, realizes noninvasive, accurate and repeatable collection of the gastrointestinal tract microorganism sample of the living yak, and is especially suitable for gastrointestinal tract microbiomics research.

The invention belongs to the technical field of medical instruments, and particularly relates to a clinical gastric lavage machine for emergency internal medicine. The device comprises a machine body and an access cover arranged on the machine body, the interior of the machine body is connected with a driving pump through a shockproof support, the driving pump is provided with a first flow guide pipe, a second flow guide pipe and a third flow guide pipe, and the machine body is provided with a control assembly, a constant temperature assembly, a liquid inlet assembly, a filtering assembly and a liquid discharging assembly; the driving pump, the constant-temperature assembly, the liquid inlet assembly, the filtering assembly and the liquid discharging assembly are sequentially connected in the liquid flowing direction. Constant-temperature control is achieved through the constant-temperature assembly, the liquid inlet assembly accurately regulates and controls the flow speed, the filtering assembly adopts a two-stage filtering design and is provided with a detection unit, and the liquid discharging assembly facilitates waste liquid collection. The liquid flow path can be optimized, it is ensured that the temperature of gastric lavage liquid is constant, the flow speed is adjustable, waste liquid is effectively treated, environmental pollution is reduced, equipment performance is improved, and an efficient, safe and convenient gastric lavage solution is provided for emergency internal medicine.

The invention discloses a method for extracting active substances of bungarus multicinctus by simulating gastrointestinal tract digestion in vitro and an extract. The extraction method comprises the following steps: performing oral cavity simulation digestion on a to-be-digested mixture under the action of simulated saliva to obtain an oral cavity simulation digestion extract; the mixture to be digested comprises bungarus parvus and water, and the mass volume ratio of the bungarus parvus to the water is 1: 10-1: 50 g / mL; performing stomach simulated digestion on the oral cavity simulated digestion extract under the action of simulated gastric juice to obtain a stomach simulated digestion extract; the stomach simulated digestion extract is subjected to intestinal simulated digestion under the action of simulated intestinal juice, and the extract is prepared. According to the method, in-vitro digestion simulation and bungarus multicinctus active ingredient extraction are combined for the first time, and mild, efficient, green and directional extraction of bungarus multicinctus active substances is achieved.

The utility model discloses a nursing pressurizing gastric lavage device, which relates to the technical field of gastric lavage and comprises a box body, a first partition plate is fixedly connected inside the box body and divides the inside of the box body into a gastric lavage liquid chamber and a waste liquid chamber, and a first water pump is fixedly connected to the top of the box body. A second water pipe is fixedly connected to a water outlet of the first water pump, a gastric lavage pipe is fixedly connected to the tail end of the second water pipe, a waste liquid pipe is fixedly connected to the gastric lavage pipe, a second water pump is fixedly connected to one side of the box body, and a water inlet of the second water pump is fixedly connected with the tail end of the waste liquid pipe; a water outlet of the second water pump is fixedly connected with a second waste liquid pipe, and a heating mechanism is mounted at the top of the box body. The gastric lavage liquid is preheated through water in the preheating chamber and then heated through water in the heating chamber, so that the temperature loss speed of the gastric lavage liquid is reduced, the comfort of a patient during gastric lavage operation is improved, and the gastric lavage device is very convenient to use.

This invention provides a glycosylated peptide chelated iron pyrophosphate supplement, its preparation method, and its application. The raw materials for preparing the glycosylated peptide chelated iron pyrophosphate supplement include glycosylated peptides, iron pyrophosphate, and a solubilizer. The glycosylated peptide is a β-glucan-grafted casein phosphopeptide, and the solubilizer is sodium pyrophosphate. The glycosylated peptide chelated iron pyrophosphate supplement of this invention exhibits good water solubility, color stability over a wide pH range, coexistence with nutrients such as vitamin C and oils, high iron loading capacity, good stability in gastric juice, sustained iron release in simulated intestinal fluid, and high iron absorption and utilization rate, significantly improving anemia in iron-deficiency anemia mice. The excellent absorption performance and superior physicochemical properties of the glycosylated peptide chelated iron pyrophosphate supplement of this invention make it a potential candidate for widespread application in the iron supplement market.

The invention discloses a visual constant-temperature closed gastric lavage device, and relates to the field of medical instruments, the visual constant-temperature closed gastric lavage device comprises gastric lavage equipment, the outer side of the gastric lavage equipment is provided with a stomach tube, a liquid outlet tube and a liquid inlet tube, the stomach tube, the liquid outlet tube and the liquid inlet tube are all arranged on one side of the front side of the gastric lavage equipment, and the other end of the liquid outlet tube is connected with a connecting assembly in an inserted mode. By the adoption of the structure, effective connection of gastric lavage liquid, a gastric lavage pipeline and eluate can be achieved, the whole gastric lavage link is relatively closed, the safety of gastric lavage operation is improved, meanwhile, the manually-prepared gastric lavage liquid can be converted into constant-temperature normal saline and proceeds to precise medical treatment, and on the basis of closed gastric lavage equipment, the working efficiency is improved. A visual constant-temperature heater and a liquid inlet path heating body are additionally arranged, gastric lavage liquid can be rapidly heated to a set temperature, temperature sensors are arranged at an inlet and an outlet of a liquid inlet pipe, the temperatures of the gastric lavage liquid before and after heating are monitored, and intelligent constant-temperature heating control of a controller is facilitated.

This invention relates to a strain of *Lactobacillus plantarum* with uric acid-lowering function (…). Lactobacillus plantarum YLW67 and its applications: This strain was isolated from red sour soup, a traditional fermented food from Guizhou, and is deposited at CGMCC, accession number No. 37373. This strain exhibits excellent tolerance to the gastrointestinal environment, with a survival rate exceeding 40% after treatment in simulated gastric fluid at pH 3.0 and simulated intestinal fluid at pH 8.0. In vitro experiments show that it can completely degrade inosine and guanosine within 9 hours. Animal experiments have confirmed that it can effectively reduce serum uric acid levels in hyperuricemia model mice. This invention also provides a probiotic composition containing this strain and its preparation method, including steps such as large-scale culture, cell collection, freeze-drying, and formulation. This strain and composition can be used to prepare uric acid-lowering functional foods, health foods, or dietary supplements, and have promising applications in improving hyperuricemia and related metabolic diseases.