337 results about "Stomach part" patented technology

The invention discloses a vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions and a preparation method and application thereof, the vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions comprises three layers, namely a core layer, a middle layer and an outer layer from inside to outside in sequence; the core layer is formed by coating vitamin K2 with a zein-lac hydrophobic core, the middle layer is a pea protein-pectin electrostatic compound, and the outer layer is sodium alginate and chitosan double-network gel. The micro-capsule system provided by the invention can be tightly combined in a gastric acid environment after being orally taken, the release of active ingredients in the stomach is reduced, and then the micro-capsule system stays at intestinal mucosa for a long time and slowly releases contents, so that the functions of the micro-capsule system are slowly presented outside, the half-life period is prolonged, and the action effect is improved. Vitamin K2 directly or indirectly participates in and regulates various physiological processes related to health, and plays an important role in the aspects of maintaining bone health, preventing cardiovascular diseases, protecting nerves, improving metabolism and the like.

The invention belongs to the technical field of microorganisms, and relates to high-activity plant lactobacillus KL100 for relieving anxiety and depression and application of the high-activity plant lactobacillus KL100. The plant lactobacillus provided by the invention is KL100, is preserved in the China General Microbiological Culture Collection Center (CGMCC), has a preservation number of CGMCC No.27192, and is classified and named as the plant lactobacillus. The plant lactobacillus is KL100, has a good gastrointestinal passing rate, shows a breeding characteristic in the stomach after being embedded, is improved in cholate-resistant survival rate, and can be used for preparing the plant lactobacillus. According to the application disclosed by the invention, the expression of IL-1beta and TNF-alpha in a mouse body can be effectively reduced, the expression of IL-10 can be improved, and the secretion of 5-hydroxytryptamine by chromaffin cells in intestinal tracts can be promoted, so that anxiety and depression can be relieved, the strain resource is expanded, the development of the biological medicine field is promoted, and a new direction is provided for treating anxiety and depression.

The invention provides the nano-liposome for embedding the cod bone peptide calcium chelate, so that the digestion stability of the cod bone peptide calcium chelate is enhanced, targeted release of Ca < 2 + > in small intestines is facilitated, and the bioavailability of the cod bone peptide calcium chelate is further improved. The amino acid sequence of the cod bone calcium chelating active peptide is SSGPGGERGPp. The nano-liposome disclosed by the invention can ensure the structural integrity in the stomach to protect the cod bone peptide calcium chelate from being damaged, and can release the peptide calcium chelate in the intestinal digestion process, so that the digestion stability of the cod bone peptide calcium chelate is improved, and the targeted delivery of the cod bone peptide calcium chelate is realized.

The invention discloses a stomach digital model construction method and system based on three-dimensional reconstruction and image analysis, and the method comprises the steps: obtaining stomach CT, MRI and ultrasonic image data through a multi-modal medical image collection device, carrying out the preprocessing of an original image through a preset standardization protocol, and obtaining a multi-source image data set; according to the registration image data set, anatomical structure features F (F represents feature vectors and comprises edge, texture and shape information) of each modal image are extracted through a convolutional neural network, and multi-modal features are fused to obtain a first comprehensive feature set; enhancing the first comprehensive feature set to obtain a second comprehensive feature set; functional verification is conducted on the four-dimensional model through a virtual simulation platform, response characteristics of the model in different physiological states are calculated through a Monte Carlo simulation method, and a final high-precision four-dimensional stomach digital model is generated.

The invention provides a stomach tube auxiliary system which comprises a pressure sensor, a detection indicating lamp and a detection processing module, the detection processing module is connected with the pressure sensor and the detection indicating lamp, and the pressure sensor is arranged at the end, entering the throat, of a stomach tube; the detection processing module determines whether the stomach tube enters the stomach or not according to the pressure value detected by the pressure sensor in the process that the stomach tube enters the first depth range in the throat, and if not, the detection indicating lamp is controlled to be turned on in a second color, whether the stomach tube enters the stomach or not is determined according to the pressure value detected by the pressure sensor in the process that the stomach tube enters the second depth range in the throat, if the stomach tube enters the stomach, the detection indicating lamp is controlled to be turned on in the first color, and if the stomach tube does not enter the stomach, the detection indicating lamp is controlled to be turned on in the third color; therefore, a medical worker can adjust the insertion direction of the stomach tube by checking the lighting color of the detection indicating lamp, and the safety of a patient is guaranteed.

The invention discloses hydrogel with a weight losing effect and a preparation method and application thereof, and relates to the technical field of hydrogel preparation, the hydrogel is prepared from polysaccharide gum, cellulose or derivatives thereof and fiber powder through physical crosslinking, a mixed solution of the polysaccharide gum, the cellulose or the derivatives thereof and the fiber powder is subjected to high-pressure homogenization treatment before physical crosslinking; the weight ratio of the polysaccharide gum to the cellulose or the derivative thereof to the fiber powder is 1: (100-300): (20-50); the polysaccharide gum is high-esterification-degree pectin, and the ratio of the weight-average molecular weight to the number-average molecular weight of the polysaccharide gum is 1.5-6; the fiber powder comprises apple fiber powder and oat fiber powder, and the weight ratio of the apple fiber powder to the oat fiber powder is 1: (1-5). The structural stability of the hydrogel can be improved, the hydrogel is prevented from being degraded or broken due to gastric juice and stomach extrusion, the emptying time of the hydrogel in the stomach is prolonged, and the problem that the duration of satiety of the hydrogel is short is solved.

The invention relates to the technical field of digestive endoscopes, in particular to a digestive endoscopy simulation device which comprises a base, and four sets of supporting legs used for supporting the device are fixedly connected to the bottom of the base; the device further comprises a first simulation bin, the middle position of the top of the first simulation bin is provided with a stomach simulation area for digestive endoscopy practice, and a first empty groove for installing a cleaning device is formed in the position, located on one side of the stomach simulation area, of the top of the first simulation bin. A second empty groove is formed in the top of the first simulation bin and located on the other side of the stomach simulation area, at the moment, the contact positions of a first scraper and a second scraper with the stomach simulation area are controlled through mutual adjustment of a second hydraulic oil cylinder and a third hydraulic oil cylinder, the interior of the stomach simulation area can be cleaned and scraped, manual work is not needed, and the working efficiency is improved. High-intensity cleaning can be effectively carried out on the interior of the stomach simulation area, the health of the internal environment of the simulation device is kept, and the service life of the device is prolonged.

The invention relates to the field of microorganisms, and discloses a Lactococcus lactis subsp. Lactis VB346 which is preserved in the China Center for Type Culture Collection on September 20, 2024, and the preservation number is CCTCC NO: M 20242013. The invention further discloses a preparation method of the Lactococcus lactis subsp. Lactis VB346. The lactococcus lactis subsp. Lactis VB346 disclosed by the invention has the capability of efficiently degrading purine nucleoside, and can decompose purine nucleoside in ingested food in intestinal tracts, so that the absorption amount of purine nucleoside by small intestines is reduced. The polypeptide has the ability of degrading bilirubin, and can be used for treating or improving hyperbilirubinemia, or improving liver and gall injury caused by hyperbilirubin; meanwhile, the acid resistance required by survival in the stomach, the cholate tolerance required by survival in the intestinal tract and the stable survival ability in the intestinal tract are achieved, and the bacillus subtilis has huge application prospects in preparation of drugs, microbial agents, health care products or food.

The invention relates to a weight-losing and stomach-occupying device and a manufacturing method thereof.The weight-losing and stomach-occupying device is arranged in an inhalable mode and comprises a jelly substrate and hydrogel microspheres at least partially wrapped in the jelly substrate, and each hydrogel microsphere comprises a hydrogel microsphere body and a waterproof degradable film wrapping the hydrogel microsphere body; the material of the waterproof degradable film comprises chitosan and sodium alginate, the particle size of the hydrogel microsphere is 300-500 [mu] m, the waterproof degradable film can prevent the volume expansion of the hydrogel microsphere body in the jelly matrix, and the waterproof degradable film can be decomposed in a gastric acid environment to expose the hydrogel microsphere body wrapped in the waterproof degradable film, so that the size of the hydrogel microsphere body is reduced, and the hydrogel microsphere body is protected. The hydrogel microsphere body absorbs water to swell, stomach occupying is achieved, gastric emptying is prolonged, food intake is reduced through stomach occupying, the weight losing effect is achieved, and the weight losing and stomach occupying device is free of a rigid mechanical structure, has the amorphous characteristic, is smaller in compression and stimulation on the stomach, has flavor and can achieve the weight losing function when being taken, and the weight losing and stomach occupying device is suitable for being used for people. And a user can use the device more comfortably, so that the acceptability is higher, and the compliance of the user is improved.

The present invention discloses a nasogastric feeding device for nursing the digestive tract with anti-backflow, which relates to the field of nasogastric feeding technology, including a feeding device and a hose, wherein the feeding device includes a driving rod and a housing, the upper and lower ends of the housing are respectively provided with end caps and a sleeve, a pressing plate and a mesh plate are installed inside the housing, a cavity is formed between the end cap and the sleeve, a four-way pipe is installed on the end cap, an air pump and a control valve are installed inside the four-way pipe, the pressing plate and the mesh plate are provided with a driving rod, and the four ports of the four-way pipe are respectively connected to the external environment, the cavity, the air pump and the space inside the housing. The present invention performs air extraction before food processing to prevent the liquid food from carrying a large amount of air into the patient's stomach during the infusion period, thereby preventing the patient from experiencing bloating. At the same time, the hose is provided with an anti-backflow mechanism to prevent the phenomenon of gastric fluid backflow due to the patient's body posture.

The invention relates to the technical field of medicines, and discloses a peptide-containing composition for improving human immunity and a preparation method thereof. The peptide-containing composition is prepared by mixing the following components: an active polypeptide liposome, an antioxidant, a sweetening agent and a flocculating agent according to a ratio of (8-25): (1-3): (2-4): 1, so as to obtain the peptide-containing composition, wherein the active polypeptide liposome, the antioxidant, the sweetening agent and the flocculating agent are mixed according to a ratio of (8-25): (1-3): (2-4): 1. The active polypeptide liposome is granular and has a double-layer embedding structure; the active polypeptide liposome comprises the following components in percentage by mass: 60%-80% of polypeptide concentrated solution, 10%-40% of amino acid, 5%-30% of vitamin and 5%-18% of calcium. The peptide-containing composition is an oral liquid preparation and is good in palatability, polypeptide active ingredients are not affected by stomach digestion and can be fully released in small intestines, the absorbance of the polypeptide active ingredients in a human body is improved, and therefore the health care effect is enhanced.

A system for imaging one or more particular structures in the stomach within a workspace is provided. In one embodiment, the system comprises: a) an active capsule endoscope positionable in the stomach, comprising a camera, an inertial measurement unit, and a permanent magnet; the driving unit comprises a Hall sensor array located at the bottom of the working space and a plurality of magnetic field generators used for generating expected magnetic fields; and c) a control unit.

The invention discloses a preparation method of bread containing a ternary covalent compound. The preparation method comprises the following steps: preparing the following raw materials: 300 g of flour, 90-120 g of water, 4-6 g of yeast powder and 30-50 g of granulated sugar; the bread is prepared from, by weight, 1-3 g of salt, 1-2 eggs, 4-6 g of bread improver and 25-35 g of butter. 3 g to 6 g of a ternary covalent complex; the bread raw materials are mixed and kneaded into dough for primary fermentation, the dough is divided and put into a mold for secondary fermentation after primary fermentation, baking is conducted after secondary fermentation is completed, and finished bread is obtained after baking is completed. The protein-polysaccharide-polyphenol ternary complex is added into the bread, so that the oxidation resistance of the bread can be effectively improved, the digestion degree of procyanidine in the stomach is reduced, the absorption effect of intestinal tracts is improved, the bioavailability is improved, and meanwhile, the stability of the bread is also improved. The polyphenol is stable in the stomach, can be massively released in the intestinal tract after being digested in the intestinal tract, is favorable for maintaining the balance of beneficial bacteria and harmful bacteria in the intestinal tract, and promotes the health of the intestinal tract.

The invention belongs to the technical field of microorganisms, and relates to new application of acetobacter pasteurianus CGMCC No.3089 and an alcoholism-reducing and alcoholism-relieving bacterial agent. The strain has strong alcohol tolerance and acid resistance, can survive well in a human gastric juice environment, and can degrade alcohols in the stomach. The strain can effectively degrade miscellaneous oleyl alcohol and ethanol in vivo, can effectively eliminate headache and drunkenness of drinkers, has remarkable alcoholism-reducing and alcoholism-relieving functions, and can be used for preparing alcoholism-relieving and liver-protecting products. The strain and the prepared hangover-alleviating and liver-protecting microbial agent can also be combined with other auxiliary materials or medicinal and edible food materials to prepare medicines, health-care products or foods and the like, and are applied to the field of hangover-alleviating and liver-protecting. The product is natural and safe, has a probiotic effect, and can reduce the damage of alcohol to the liver and improve the metabolic capability of a human body. The invention has great market potential and application prospect, and can effectively meet the requirements of hangover-alleviating and liver-protecting products.

The invention belongs to the technical field of biology, and particularly discloses a pH response type probiotic-liposome hybrid system, a preparation method and application thereof, and the pH response type probiotic-liposome hybrid system comprises engineered escherichia coli Nissle 1917, pinocembrin-loaded biotinylated liposome and an enteric polymer; wherein the engineered escherichia coli Nissle 1917 is in non-covalent binding with the biotinylated liposome loaded with the pinocembrin through surface display streptavidin, so that EcNPIN is formed, and the EcNPIN is coated with an enteric polymer, so that the pH response type probiotic-liposome hybrid system is formed. The pH response type probiotic-liposome hybrid system EcNPIN-L provided by the invention can resist the acidic environment of the stomach, completes pH response release and colonization in the intestinal tract, solves the problems of lack of intestinal tract localization of drugs and low probiotic treatment efficiency, improves the local intestinal tract concentration of pinocembrin, and promotes intestinal tract colonization of probiotics.

The invention provides a stomach tube space registration and dynamic positioning method based on historical features, and relates to the technical field of medical instruments, and the method comprises the following steps: data acquisition: recording a catheterization path curve when the catheterization of a patient succeeds, and determining the catheterization path curve as a physiological feature curve; data calibration: marking coordinates of key feature points such as an airway opening, key parts of an esophagus and a stomach entrance on the physiological feature curve; space registration: registering the real-time catheter advancing curve and the physiological characteristic curve in the same coordinate system, and aligning data; dynamic positioning: calculating the position deviation of the front end of the stomach tube, dynamically calibrating based on a deviation value, and controlling the stomach tube to move along a physiological characteristic curve, in the data acquisition step, the physiological characteristic curve is used as a historical reference for path matching in a subsequent tube indwelling process, and in the data calibration step, the tube indwelling control precision is improved by more than or equal to 15% by dividing characteristic sections; and by utilizing a historical physiological curve, the catheterization path deviation is less than or equal to 2mm, and the control precision is improved by 30%.

The invention provides application of bifidobacterium breve in preparation of a product for resisting gastric ulcer and gastric inflammation caused by helicobacter pylori, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium breve NKU BB1-2 is GDMCC NO: 65956, and the bifidobacterium breve NKU BB1-2 can antagonize helicobacter pylori colonization and relieve gastric ulcer aggravation caused by helicobacter pylori. The bifidobacterium breve NKU BB 1-2 has good helicobacter pylori antagonism ability in an in-vitro environment, and can significantly inhibit colonization growth of helicobacter pylori; animal experiments show that the bifidobacterium breve NKU BB 1-2 can relieve gastric ulcer aggravation caused by helicobacter pylori infection in vivo, and the gastric mucosa lesion is relieved, the stomach inflammation is relieved, and the stomach pH value is increased; in addition, the bifidobacterium breve NKU BB1-2 can also significantly improve the diversity of stomach microorganisms, regulate and improve the structure of the stomach microorganisms, and assist antagonism and removal of helicobacter pylori infection.

The invention relates to the field of animal health detection, and discloses a health detection method and equipment based on cattle stomach data and a storage medium. The method comprises the following steps: collecting characteristic time sequence data of a cattle stomach through an implantable stomach capsule; performing health state labeling processing on the feature time sequence data to obtain labeled feature data; performing parameter optimization processing on the preset linear regression model to obtain a first analysis model; performing parameter optimization processing on the preset random forest model to obtain a second analysis model; the method comprises the following steps: collecting monitoring time sequence data of a cattle stomach through an implantable stomach capsule; performing detection processing on the monitoring time sequence data to obtain a first analysis value, and performing detection processing on the monitoring time sequence data to obtain a second analysis value; and generating a health state corresponding to the cattle based on the first analysis value and the second analysis value. In the embodiment of the invention, under the condition that the deviation ratio of the analysis value is not high, the effect of detecting the accurate cattle health state based on the physiological data of the cattle stomach is realized.

An apparatus for treating obesity of a patient having a stomach with a food cavity. The apparatus comprising a volume filling device adapted to be at least substantially invaginated by a stomach wall portion of the patient with the outer surface of the volume filling device resting against the stomach wall, such that the volume of the food cavity is reduced in size by a volume substantially exceeding the volume of the volume filling device. The apparatus further comprises at least one adjustable stretching device adapted to be at least substantially invaginated by a stomach wall portion of the patient with the outer surface of the stretching device resting against the stomach wall and adapted to stretch a portion of stomach wall, and a fluid connection device interconnecting the volume filling device and the stretching device.

The utility model relates to the field of massagers, in particular to a portable handheld acupoint massager. The utility model provides a portable handheld acupoint massager which can massage acupoints of a patient so as to relieve stomach pain of the patient. A portable handheld acupoint massager comprises a bottom plate, a shell, a handle, fixing shafts, rolling cylinders, rubber soft sleeves and the like, the upper side of the bottom plate is connected with the shell, the upper side of the shell is connected with the handle, the left portion and the right portion of the shell are both connected with the fixing shafts, the fixing shafts are both rotationally connected with the rolling cylinders, and the lower sides of the left portion and the right portion of the bottom plate are both connected with the rubber soft sleeves. The electric push rod is started, the pressing plate is pushed to move downwards, the telescopic pressing rod is driven to move downwards on the fixing plate, the telescopic pressing rod makes contact with the abdomen of a patient, and the effect that acupoint massage can be conducted on the patient so as to relieve stomach pain of the patient can be achieved.

The invention discloses a long-acting pellet suitable for gastric absorption and a preparation method of the long-acting pellet. The long-acting pellet is prepared from the following components in parts by mass: 0.01-1 part of a medicine, 1-2.5 parts of a filler, 0.2-0.7 part of a modified pore-foaming agent mixture, 1-2.5 parts of an improved adhesive mixture and 0.1-0.7 part of an improved sonokinetic response agent. Wherein the modified pore-foaming agent mixture is prepared from a modified pore-foaming agent and glycosylated saponin, the modified pore-foaming agent is prepared by mixing a pore-foaming agent and seleno-amino acid according to a mass ratio of 4: 1, the improved adhesive is mixed with the adhesive through BHP-SH, and ionic crosslinking is performed by using CaCl2 to form a covalent ion dual network, so that the stomach adhesiveness is enhanced; the sonokinetic response agent is improved by the coated poria cocos extract, and the long-acting pellet is prepared by adopting a wet granulation method or a fluidized bed method, has the characteristics of slow release, long acting, targeted stomach absorption and responsive drug release, and is suitable for treating stomach diseases such as gastritis.

The invention relates to the field of detection for simulating the capsule dissolution process, in particular to a detection system and method for simulating the capsule dissolution process, and the system comprises an environment simulation module which is used for simulating the internal environment of the stomach of a human body, comprising a reaction cup used for containing simulated gastric juice and a temperature control unit connected with the reaction cup and used for adjusting the temperature in the reaction cup. The stirring module is connected with the environment simulation module and used for simulating the flowing environment in the stomach of the human body; the detection module is connected with the environment simulation module and used for collecting dissolution characteristic data in the capsule dissolution process; and the control module is used for judging whether the accuracy of capsule dissolving capacity detection meets the requirement or not according to the variance of the dissolving ratio of the capsule in the simulated gastric juice under the same environment, and determining the processing mode of the dissolving degree according to the judgment result of the capsule dissolving capacity. According to the invention, the real-time detection of the dissolution process of the capsule in gastric acid is realized through a simulation experiment.

The invention discloses a medical organ image automatic segmentation and discrimination marking system based on deep learning. The system comprises an acquisition module, an identification module, a determination module, a determination module, an adjustment module, a marking module and an output module. According to the method, temporary grids are preliminarily screened out by analyzing the ratio and the surface roughness of deep color areas; determining key grids in combination with physiological status characteristics such as saturation and creeping frequency; the threshold value is dynamically adjusted according to key grid data, and the accuracy is improved; and finally, synthesizing the echo uniformity and the ideal polyp image, and determining the target polyp image, thereby reducing the risk of errors of a single model, facilitating the reduction of missed diagnosis and misdiagnosis, improving the diagnosis reliability, assisting the formulation of a scientific treatment scheme, and improving the diagnosis efficiency. The problems of inaccuracy in polyp recognition and inaccuracy in image segmentation caused by poor adaptability to unstable stomach peristalsis due to excessive dependence on a model are effectively solved.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus plantarum HNGD-YC1 capable of degrading free-state advanced glycosylation end products (AGEs) and application of the lactobacillus plantarum HNGD-YC1. The strain is classified and named as Lactobacillus plantarum, and the preservation number of the strain is CCTCC M 20251498. The strain can effectively degrade free AGEs, and has good acid resistance and cholate resistance. Besides, lactic acid bacteria are adopted for degrading free AGEs in food for the first time, the degradation rate is 69.3%, and the lactobacillus has an excellent probiotic function, is high in strain activity, can easily pass through the stomach and be planted in the intestinal tract and is low in economic cost; the invention provides a novel safe and sustainable method for solving the problem that the food-sourced harmful factor AGEs enters the body to damage the health, and also provides a safer and more effective diet strategy for people with AGEs-related metabolic diseases, thereby being beneficial to promoting the healthy life of people.

A method of deploying an intraluminal device to the cardiac region of the stomach and an intraluminal system used to deploy an intraluminal device to the cardiac region of the stomach, wherein the intraluminal device has a wall defining a surface and an open portion of the surface that is adapted to be aligned with the gastroesophageal (GE) junction. The surface and the cardiac portion of the stomach are conformable with each other. The method includes deploying the intraluminal device trans-orally to the stomach with an endoscopic deployment device and retaining the device against the cardiac region of the stomach with the open portion generally aligned with the GE junction. The intraluminal device is fastened to the stomach from the abdominal cavity with at least one laparoscopic instrument while concurrently visualizing the device with an endoscope in the stomach while it is being fastened. The laparoscopic instrument is adapted to respond to the endoscope in order to adjust location between the laparoscopic instrument and intraluminal device while the laparoscopic instrument is fastening the intraluminal device.

The invention relates to the technical field of medical image analysis, in particular to a stomach image intelligent detection system and method based on YOLOv8, and aims to realize efficient and accurate auxiliary detection of early gastric cancer (EGC). By introducing an improved YOLOv8 (EGC-YOLOv8) network model, the system can accurately identify and analyze minimal lesion characteristics in gastroscope images, such as mucous membrane color change, texture abnormity, minimal upheaval or depression and the like, and the accuracy of auxiliary detection is remarkably improved. Meanwhile, the system adopts a video frame-by-frame analysis technology to ensure that each frame of image is subjected to fine detection, so that the problem that missed diagnosis or misdiagnosis is easy to occur in a traditional detection means is effectively solved.

A thermal therapy system, device, and method of using the same are disclosed. A local hypothermia treatment of the pancreas using delivery and placement procedures in a patient's stomach, including a cooling balloon system, is disclosed. This can be used for the treatment of pancreatitis in a patient. The cooling balloon system may have a mechanism for acting on pancreatitis without systemically affecting or inducing hypothermia in the patient. The local hypothermia system may have a simplified delivery system and can be aimed at reducing the patient's pain while reducing the metabolic activity of the inflamed pancreatitis in the patient.

The present application relates to the technical field of Raman spectrum detection, and in particular to a stomach H. pylori infection detection method based on Raman spectrum. The method performs Raman spectrum detection on a gastric juice sample to obtain a Raman spectrum curve; a healthy Raman spectrum curve of a healthy gastric juice sample is obtained and constructed into a healthy sample spectrum library; according to the Raman intensity difference and waveform distribution similarity of each healthy Raman spectrum curve in the healthy sample spectrum library with other healthy Raman spectrum curves in a specified wavelength range, a representative weight of each healthy Raman spectrum curve is obtained; according to the Raman intensity distribution similarity of the Raman spectrum curve of the current patient with each healthy Raman spectrum curve in the specified wavelength range and the representative weight of each healthy Raman spectrum curve, the infection degree of the current patient is obtained, and it is determined whether the current patient is infected with H. pylori. The present application effectively improves the preparedness and universality of H. pylori detection by obtaining the infection degree.

The invention discloses glycyrrhiza polysaccharide for preventing and treating acute stomach injury and a preparation method and application thereof. The molecular weight of the glycyrrhiza polysaccharide is 60 kDa, the percentage content of protein is smaller than or equal to 5%, and the mass percentage content is larger than or equal to 60% according to glucose; the preparation method comprises the following steps: carrying out ethanol reflux degreasing on liquorice, carrying out water extraction and alcohol precipitation, removing protein by adopting Sevag, dialyzing by using a 8-13 kDa dialysis bag, carrying out rotary concentration, and freeze-drying to obtain the glycyrrhiza polysaccharide. Animal experiments show that the glycyrrhiza polysaccharide has a protective effect on acute alcoholic stomach injury, the content of MDA and MPO in animal stomach tissues can be reduced, and the stomach injury is relieved by reducing lipid oxidation and neutrophil infiltration level; the content of gastric tissue pepsase and VEGF (vascular endothelial growth factor) can be increased, and the gastric mucosa can be protected in the aspects of maintaining the stomach environment, promoting blood vessel healing and reducing the injury time and degree; and the medicine also has a pathological repair effect on acute stomach injury.

The invention relates to the technical field of pharmaceutical preparations, in particular to oral in-situ gel and a preparation method and application thereof.The in-situ gel is prepared from, by weight, 0.09-2.5 parts of American cockroach extract, 0.3-3 parts of gel matrix, 86.7-99.4 parts of water and a pH regulator, the in-situ gel is formed by a periplaneta americana extract, a gel matrix and water according to a specific ratio in the presence of a pH regulator, the gel is a clear pale yellow to yellow solution at room temperature, the gel is formed in gastric juice after oral administration as a solution, the gel can be retained in the stomach, more importantly, the burst release of the medicine can be remarkably reduced, and the curative effect of the medicine is improved. The medicine dissolution is improved, and the medicine is ensured to be continuously and slowly released to play a role in treating the peptic ulcer.