114 results about "Stomach part" patented technology

An apparatus for treating obesity of a patient having a stomach with a food cavity. The apparatus comprising a volume filling device adapted to be at least substantially invaginated by a stomach wall portion of the patient with the outer surface of the volume filling device resting against the stomach wall, such that the volume of the food cavity is reduced in size by a volume substantially exceeding the volume of the volume filling device. The apparatus further comprises at least one adjustable stretching device adapted to be at least substantially invaginated by a stomach wall portion of the patient with the outer surface of the stretching device resting against the stomach wall and adapted to stretch a portion of stomach wall, and a fluid connection device interconnecting the volume filling device and the stretching device.

The invention discloses a long-acting pellet suitable for gastric absorption and a preparation method of the long-acting pellet. The long-acting pellet is prepared from the following components in parts by mass: 0.01-1 part of a medicine, 1-2.5 parts of a filler, 0.2-0.7 part of a modified pore-foaming agent mixture, 1-2.5 parts of an improved adhesive mixture and 0.1-0.7 part of an improved sonokinetic response agent. Wherein the modified pore-foaming agent mixture is prepared from a modified pore-foaming agent and glycosylated saponin, the modified pore-foaming agent is prepared by mixing a pore-foaming agent and seleno-amino acid according to a mass ratio of 4: 1, the improved adhesive is mixed with the adhesive through BHP-SH, and ionic crosslinking is performed by using CaCl2 to form a covalent ion dual network, so that the stomach adhesiveness is enhanced; the sonokinetic response agent is improved by the coated poria cocos extract, and the long-acting pellet is prepared by adopting a wet granulation method or a fluidized bed method, has the characteristics of slow release, long acting, targeted stomach absorption and responsive drug release, and is suitable for treating stomach diseases such as gastritis.

The invention discloses a medical organ image automatic segmentation and discrimination marking system based on deep learning. The system comprises an acquisition module, an identification module, a determination module, a determination module, an adjustment module, a marking module and an output module. According to the method, temporary grids are preliminarily screened out by analyzing the ratio and the surface roughness of deep color areas; determining key grids in combination with physiological status characteristics such as saturation and creeping frequency; the threshold value is dynamically adjusted according to key grid data, and the accuracy is improved; and finally, synthesizing the echo uniformity and the ideal polyp image, and determining the target polyp image, thereby reducing the risk of errors of a single model, facilitating the reduction of missed diagnosis and misdiagnosis, improving the diagnosis reliability, assisting the formulation of a scientific treatment scheme, and improving the diagnosis efficiency. The problems of inaccuracy in polyp recognition and inaccuracy in image segmentation caused by poor adaptability to unstable stomach peristalsis due to excessive dependence on a model are effectively solved.

A method of deploying an intraluminal device to the cardiac region of the stomach and an intraluminal system used to deploy an intraluminal device to the cardiac region of the stomach, wherein the intraluminal device has a wall defining a surface and an open portion of the surface that is adapted to be aligned with the gastroesophageal (GE) junction. The surface and the cardiac portion of the stomach are conformable with each other. The method includes deploying the intraluminal device trans-orally to the stomach with an endoscopic deployment device and retaining the device against the cardiac region of the stomach with the open portion generally aligned with the GE junction. The intraluminal device is fastened to the stomach from the abdominal cavity with at least one laparoscopic instrument while concurrently visualizing the device with an endoscope in the stomach while it is being fastened. The laparoscopic instrument is adapted to respond to the endoscope in order to adjust location between the laparoscopic instrument and intraluminal device while the laparoscopic instrument is fastening the intraluminal device.

The present application relates to the technical field of Raman spectrum detection, and in particular to a stomach H. pylori infection detection method based on Raman spectrum. The method performs Raman spectrum detection on a gastric juice sample to obtain a Raman spectrum curve; a healthy Raman spectrum curve of a healthy gastric juice sample is obtained and constructed into a healthy sample spectrum library; according to the Raman intensity difference and waveform distribution similarity of each healthy Raman spectrum curve in the healthy sample spectrum library with other healthy Raman spectrum curves in a specified wavelength range, a representative weight of each healthy Raman spectrum curve is obtained; according to the Raman intensity distribution similarity of the Raman spectrum curve of the current patient with each healthy Raman spectrum curve in the specified wavelength range and the representative weight of each healthy Raman spectrum curve, the infection degree of the current patient is obtained, and it is determined whether the current patient is infected with H. pylori. The present application effectively improves the preparedness and universality of H. pylori detection by obtaining the infection degree.

This invention discloses a pharmaceutical composition and its preparation method for treating atrophic gastritis, precancerous lesions of the stomach, and stomach cancer, belonging to the field of traditional Chinese medicine preparation technology. The pharmaceutical composition is prepared by a specific two-step microbial fermentation process using Astragalus membranaceus, Hericium erinaceus, Curcuma zedoaria, Actinidia chinensis root, Camptotheca acuminata fruit, Hedyotis diffusa, Coptis chinensis, Taraxacum mongolicum, Viola yedoensis, Corydalis yanhusuo (processed with vinegar), Phellodendron chinense, Solanum nigrum, Scutellaria baicalensis, Panax notoginseng, Zingiber officinale, Piper cubeba, Cuttlebone, Fritillaria thunbergii, roasted soybean, and red yeast rice. This invention significantly improves the bioavailability of the active pharmaceutical ingredients through the synergistic effect of the multifunctional groups of traditional Chinese medicine and the enhanced effect of microbial fermentation. It can systematically reverse gastric mucosal atrophy and intestinal metaplasia, effectively improve microcirculation, and inhibit Helicobacter pylori, while also exhibiting good safety. This provides a novel and effective treatment for the aforementioned gastric diseases.

The invention discloses a novel multi-dimensional cascade assembled micro-nano intestinal delivery carrier and a preparation method and application thereof, and relates to the field of biological medicine and functional materials.The preparation method comprises the following steps that S1, phospholipid and a sterol regulator are dissolved in an ethanol solution to form a lipid film, the solution is added for hydration, and the lipid film is obtained; then treating to obtain a monodisperse vesicle suspension; s2, adding the vesicle suspension into the composite solution, and inducing adsorption of an inner shell layer to form intermediate particles; and S3, dropwise adding a cationic electrolyte solution into the intermediate particle suspension, and carrying out interface electrostatic complexing and coordination cross-linking reaction to obtain the delivery carrier. By constructing a cascade self-assembly delivery carrier with a multi-layer core-shell structure, the problem that a large amount of drugs are inactivated due to insufficient shielding in an extreme stomach environment can be solved, so that space-time limited release of the drugs in specific parts of intestinal tracts is realized, and oral bioavailability and targeted therapy efficiency are greatly improved.

The present application relates to a kind of brain health nutrition capsule and its preparation method, belong to the technical field of functional health food.The preparation method includes the following steps: taking walnut kernel powder, DHA algal oil microcapsule powder, phosphatidylserine, ginkgo biloba extract and oligosaccharides are mixed, soft material is prepared by adding purified water, granulation is extruded by screen, and granule core is obtained by drying;Granule core is coated, and brain nutrition core granule is obtained by drying;Prepare base nutrition layer granule;Brain nutrition core granule and base nutrition layer granule are mixed, and composite granule is obtained, and composite granule is filled into capsule.The present application not only solves the three major obstacles of oxidation, precipitation and vitamin degradation of high polyphenol walnut base formula in gastric acid environment, but also unexpectedly builds from stomach protection to intestinal microecological optimization, finally realizes the cascade effect of brain nutrition efficient absorption, meets the core needs of teenagers brain health and intelligence, and truly realizes the effect of brain health and intelligence.

The invention is suitable for the technical field of medicine, and provides a stomach medicine capsule and a preparation method thereof, the stomach medicine capsule is prepared from 20-30 parts of Chinese angelica, 7-11 parts of phoenix-tail fern, 15-19 parts of radix berberidis, 5-9 parts of radix aucklandiae, 2-4 parts of reed seed, 13-17 parts of sea snail and auxiliary materials; the preparation method comprises the steps of raw material pretreatment, ethanol reflux extraction, vacuum concentration, spray drying, mixing granulation, capsule filling and packaging. The traditional Chinese medicine raw materials in a specific proportion are screened, the synergistic effect of resisting inflammation and bacteria, regulating qi to relieve pain, nourishing blood and repairing, and relieving acid and protecting the stomach is achieved, and the problems that an existing stomach medicine is single in effect and large in side effect are solved; meanwhile, extraction and drying processes are optimized, the dissolution rate of effective components and the stability of the preparation are improved, and the traditional Chinese medicine composition is suitable for treating stomach diseases such as acute and chronic gastritis, gastric ulcer and hyperacidity, high in safety and suitable for long-term administration.

The utility model discloses a kind of gastric cavity plugging catheters of gastrostomy in the medical instrument technical field, the device increases plugging balloon and sealing clamping piece, can be held by inside and outside, hold stomach wall and skin to position the device, while plugging balloon seals and isolates the puncture of stomach wall inside gastric cavity, effectively avoid gastric juice to flow out, avoid gastric juice to overflow along the puncture and cause skin burning;Positioning baffle is also increased, can be unfolded inside duodenum, positioning baffle can position nutrition tube, avoid nutrition tube to slide and separate, can also effectively block pylorus, effectively avoid enteric digestive juice to enter stomach, and do not hinder gastric juice to flow into intestine normally, and by pressure relief port and pressure relief pipe, stomach is conveniently decompressed, effectively avoid that pressure is too high and nutrition liquid is refluxed to esophagus.

The invention discloses a control method of an artificial stomach, and belongs to the technical field of bionic medical instruments. Under the state that the starting signal is monitored, all the driving pieces are controlled to drive the diastole assembly according to a preset time sequence, so that the corresponding part of the artificial stomach is subjected to contraction or diastole movement, and the content in the artificial stomach is subjected to regular movement from the inlet direction of the artificial stomach to the outlet direction of the artificial stomach. By changing the time point and interval of successive movement of the whole stomach diastole assembly, the pathological characteristics of peristaltic wave conduction delay and starting time sequence disorder are simulated, and then by adjusting the interval between the contraction stop time point and the expansion starting time point, the expression of abnormal extension of the diastole and contraction switching interval or interruption of the peristaltic wave in the pathological state is re-engraved.

The invention relates to the technical field related to microcapsules, in particular to a preparation method of a wheat alpha-glucosidase inhibitory peptide microcapsule, which comprises the following steps: by taking wheat vital gluten as a raw material, carrying out enzymolysis by alkaline protease to obtain alpha-glucosidase inhibitory peptide, and then carrying out enzymolysis by adopting a sodium alginate-chitosan composite wall material system to obtain the wheat alpha-glucosidase inhibitory peptide microcapsule. By optimizing key parameters such as the core-wall ratio of 1: 2.632, the calcium chloride concentration of 2.48% and the curing time of 31.83 min, the double-layer microcapsule with the pH response characteristic is prepared by an ionic gel method. The embedding rate of the prepared microcapsule reaches 78.26%, the 2-hour release rate in simulated gastric juice (pH 2.0) is smaller than or equal to 21.38%, the 4-hour accumulative release rate in simulated intestinal juice is larger than or equal to 84.98%, and stomach protection and intestinal targeted release of the active peptide are achieved; meanwhile, the peptide loss rate of the product under the storage condition of 4 DEG C is less than or equal to 11.13%, the loss rate in the environment with the pH value of 2.0 is only 12.72%, and the stability of the active peptide is remarkably improved. The obtained product can effectively protect the activity of the alpha-glucosidase inhibitory peptide and improve the bioavailability of the alpha-glucosidase inhibitory peptide, and a new scheme is provided for developing functional hypoglycemic food.

The invention belongs to the technical field of gastric lavage devices, and particularly relates to a flow-adjustable gastric lavage device for children, which comprises a mounting base, a fixing part is arranged in the mounting base, a liquid storage part is arranged in the fixing part, a butt joint part is further arranged in the mounting base, and the lower end of the butt joint part is communicated with the liquid storage part. The upper end of the butt joint part is connected with the flushing part, the cleaning liquid in the liquid storage part is conveyed to the flushing part through the butt joint part, the cleaning liquid is conveyed to the stomach through the flushing part, meanwhile, waste liquid obtained after cleaning of the flushing part can be extracted, and cleaning of the stomach and recycling of the cleaning liquid are achieved. According to the invention, first aid can be adapted through convenient operation, and the process is simplified through tool-free quick docking; safety protection is comprehensive, double-tube isolation and scratch prevention are achieved, and mild negative pressure guarantee is achieved; the treatment efficiency and tolerance are high, the effect is improved through parallel conveying and recycling, and discomfort of children is reduced.

This invention relates to the field of pharmaceutical formulation technology, specifically to a sustained-release formulation of rifabutin, and more specifically, to a sustained-release rifabutin formulation composition for treating Helicobacter pylori infection. The key technical point of this invention is that it uses a novel antibiotic for treating Helicobacter pylori infection as the active ingredient, supplemented with specific inactive ingredients, including a hydrophilic gel-type matrix sustained-release material, a swelling agent, a buoyancy aid, and a lubricant. Through the synergistic effect of the hydrophilic gel-type matrix sustained-release material, the swelling agent, and the buoyancy aid, the composition can rapidly swell in gastric juice and maintain a floating state, thereby significantly prolonging the residence time of the formulation in the stomach and upper small intestine. This invention solves the technical problem of conventional formulations having a short residence time in the stomach and requiring frequent administration to maintain an effective antibacterial concentration, achieving the goal of effectively eradicating Helicobacter pylori by reducing the number of doses while maintaining an effective concentration at the site of infection for a longer period.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with the function of relieving stomach inflammation and a preparation method and application. The traditional Chinese medicine composition comprises a main medicine and an auxiliary medicine, the main medicine consists of cuttle bone, thunberg fritillary bulb and rheum officinale; the adjuvants comprise a first adjuvant and a second adjuvant; the first adjuvant is belladonna and daphniphyllum calycinum; the second adjuvant comprises fructus aurantii and cortex magnoliae officinalis. The traditional Chinese medicine composition provided by the invention is simple in component, only a trace amount of belladonna extract needs to be added, meanwhile, daphniphyllum calycinum is compounded, the addition of excessive other unnecessary components is avoided, and the symptom of chronic non-atrophic gastritis with erosion can be remarkably improved.

The invention discloses a dietary compound containing resveratrol and application of the dietary compound in improvement of inflammatory injury of diabetic nephropathy, and belongs to the field of functional foods and dietary supplements. The L-WPI is taken as a carrier, so that the phosphorus load of a final product is reduced from the source, the problem that the hyperphosphatemia risk of a DKD patient is possibly aggravated by a conventional whey protein raw material is solved, and the L-WPI is more suitable for nutrition intervention of people with renal hypofunction. The L-WPI-Res compound constructed through heat treatment induction can effectively protect Res from being excessively degraded in a harsh stomach acidic and enzymatic hydrolysis environment, realizes stomach stability and intestinal targeted release, improves the biological accessibility of the compound in a small intestine stage by 20-35% compared with a free monomer, fundamentally solves the bottleneck problem of low oral availability of polyphenol compounds, and has a wide application prospect. Meanwhile, the L-WPI-Res-55 DEG C compound has a synergistic enhancement effect in two aspects of regulating blood sugar potential and relieving inflammation.

The invention relates to hybrid nano-clay and a preparation method and application thereof, the hybrid nano-clay comprises hybrid nano-clay particles with adhesive power, the hybrid nano-clay particles comprise nano-clay with the surface modified with a metal polyphenol network, and the metal polyphenol network is formed by self-assembly of Zn < 2 + > and tannic acid; the mass percent of the metal polyphenol network in the hybridized nano-clay particles is not less than 33%. The hybridized nano-clay particles provided by the invention have the capabilities of resisting oxidation, resisting bacteria and stopping bleeding; the gel can be adhered to stomach tissues, and free radicals in the body can be efficiently removed; the secretion of gastric mucosa protection factors can be stimulated, the complete form of the gastric mucosa is maintained, the damaged gastric mucosa is comprehensively protected and repaired, and the stomach health level is remarkably improved.

Proposed is a gastroscopy area indication method that includes loading a gastroscopy image analysis model and setting an analysis condition of the analysis model by a model loading / condition setting part, initializing an analysis screen and displaying a picture of a normal stomach by a controller, preprocessing, by an image preprocessing part, a gastroscopy image received through an image receiving part so that subsequent image analysis is smoothly performed, analyzing the preprocessed gastroscopy image by an image analysis part by using the image analysis model based on AI, detecting and indicating, on the basis of a result of analysis by the image analysis part, at least one selected from a group of an examination area, a hernia area, and a lesion area in the gastroscopy image, and providing, by the controller, the result of analysis performed by the image analysis part.

To provide a gastrostomy catheter capable of more surely regulating the backflow of a nutrient or gastric contents from the inside of the stomach to the outside of the body.SOLUTION: The gastrostomy catheter 100 comprises a shaft 10 having a lumen 11, and a check-valve 40, wherein the check-valve 40 has a base part 41, a downward projecting part 51, and an annular 51a part 43, the shaft 10 has a body surface contact part 20 and an annular rib 23, the gap between the annular wall part 43 and the downward projecting part 51 constitutes an annular groove 44 into which the annular rib 23 fits, and a valve opening 45 is formed in the side wall of the lower end of the downward projecting part 51. A lower portion of the downward projecting portion 51 serves as a press-fitting portion 53, the press-fitting portion 53 has a large-diameter portion 54 whose size in the first direction is larger than the inside diameter of the lumen 11, and the size of the downward projecting portion 51 in the first direction gradually increases downward at a boundary portion 54a between the upper portion 52 of the downward projecting portion 51 and the large-diameter portion 54.SELECTED DRAWING: Figure 2

The invention discloses an intestinal micro-emulsified targeted release type xanthoceras sorbifolia bunge oil soft capsule and a preparation method thereof, and belongs to the technical field of functional food and health-care product preparations. The soft capsule is composed of a content containing low-temperature squeezed xanthoceras sorbifolia bunge oil and a self-microemulsion delivery system, and a gastrointestinal fluid response type capsule shell. The preparation method comprises the steps of delivery system preparation, capsule shell preparation, capsule forming, quality detection and the like. Intestinal targeted delivery, controllable disintegration and intestinal in-situ emulsification core technologies are integrated to form a synergistic effect, so that active ingredients such as nervonic acid safely pass through the stomach and are accurately released in the intestinal tract to form a nano-scale microemulsion, the bioavailability is improved from less than 20% to more than or equal to 60%, and the nano-scale microemulsion is high in compatibility with an existing production line, controllable in quality, low in industrialization cost and suitable for industrial production. The xanthoceras sorbifolia bunge oil can be promoted to be upgraded to a high-valued functional preparation.

The application provides a probiotic-loaded aerogel-hydrogel composite material and a preparation method thereof. The probiotic-loaded aerogel-hydrogel composite material comprises: a sodium alginate-gelatinized high-amylose starch aerogel; an active ingredient, wherein the active ingredient comprises probiotics, and the active ingredient is at least loaded in the pores of the sodium alginate-gelatinized high-amylose starch aerogel; and a sodium alginate-calcium chloride hydrogel coating, which is coated on the surface of the sodium alginate-gelatinized high-amylose starch aerogel loaded with the active ingredient. The probiotic-loaded aerogel-hydrogel composite material provided by the application can protect the active probiotics from passing through the stomach acid environment smoothly, and stably release the probiotics in the distal intestinal region, i.e., the colon, to achieve controllable release of the probiotics.

The invention provides an oral preparation for improving anemia after gastric resection operation and a preparation method thereof, and relates to the technical field of biological medicines. The oral preparation is prepared from the following raw materials: vitamin B12, internal factors, chickpea protein, III type collagen peptide, a pH regulator, an antioxidant and a dispersing agent. The vitamin B12 and the internal factors are taken as active ingredients, the utilization degree of the vitamin B12 is remarkably improved through the specific proportion of the vitamin B12 and the internal factors, and the prepared reagent meets the requirement that the reagent is not released in a gastric acid environment and then is slowly released in the intestinal tract, and has a remarkable effect on the anemia problem caused by deficiency of the vitamin B12 after the gastric resection operation; and the stability of the medicine is high.

This invention belongs to the field of medical device technology, specifically relating to a pediatric gastrointestinal lavage device. The device includes a gastric lavage machine body with a placement groove inside. A flushing connector is located at the upper end of the placement groove. It also includes a gastric tube comprising an inner tube and an outer tube. The inner tube is sleeved on the outside of the flushing connector, and the outer tube is coaxially disposed on the outside of the inner tube. The sidewall of the inner tube has multiple flow-blocking holes spaced evenly along the axial direction. These flow-blocking holes are composed of multiple clearance holes located in the same radial cross-section. This invention, by setting an elastic flow-blocking membrane adapted to the flow-blocking hole array on the inner tube, allows the device to automatically reduce the effective flow diameter of the tube when the negative pressure exceeds a threshold, achieving precise flow restriction and pressure reduction, and preventing damage to the delicate gastric mucosa of children due to high negative pressure.

The present application relates to the technical field of pharmaceutical compositions, and provides a composition for improving immune function, a preparation and a preparation method and application thereof, comprising: 25-40% of chlorogenic acid, 5-12% of luteolin, 10-20% of isochlorogenic acid A, 3-8% of caffeic acid, 0.5-1% of a targeting ligand, 2-5% of a microecological component, and 5-8% of a nano-carrier, and application of the composition in preparation of medicines, health products and functional foods for improving immune function, and a preparation method of the above-mentioned medicine preparation, comprising the following steps: preparing a core particle; coating the core particle with a sustained-release enteric coating to obtain a microcapsule particle; filling the microcapsule particle into a capsule shell to obtain an enteric capsule; coating the enteric capsule with a stomach-dissolving coating liquid to obtain a capsule preparation; and achieving the effect of improving the whole gastrointestinal immune function by rapidly targeting anti-inflammation in the stomach and continuously targeting regulation in the intestinal tract, and greatly improving the action efficiency and immune regulation effect of the preparation.

The invention discloses a preparation method and application of a probiotic-loaded hydrogel precursor solution for treating stomach diseases, and belongs to the field of preparation of medicinal high polymer materials. Comprising the following steps: oxidizing hyaluronic acid with sodium periodate to obtain oxidized hyaluronic acid; reacting the oxidized hyaluronic acid with dopamine to prepare dopamine modified oxidized hyaluronic acid; the preparation method comprises the following steps: carrying out amidation reaction on chitosan and N-acetyl-L-cysteine to prepare thiolated chitosan; the preparation method comprises the following steps: mixing dopamine modified oxidized hyaluronic acid and a thiolated chitosan aqueous solution with probiotics, and carrying out a cross-linking reaction under oxidation and acidic conditions to obtain a hydrogel precursor solution; the hydrogel precursor solution can be taken orally and swallowed, can be further gelatinized in situ under the condition of stomach focus oxidation, has excellent adhesion, and can be effectively retained in the stomach and keep the activity of probiotics. In addition, the hydrogel can continuously remove excessive active oxygen in the stomach, relieve the inflammatory response of gastric mucosa and remarkably improve the microenvironment of the focus.

This invention belongs to the field of medical monitoring technology, specifically relating to a pressure sensor for detecting gastric abnormalities, its preparation method, and its application. The pressure sensor uses a sandwich-structured dielectric hydrogel as the core sensing unit. The synergistic effect of the upper and lower zwitterionic hydrogels and the middle microphase-separated hydrogel helps to improve the sensor's sensitivity and stability, thereby enhancing its response to minute pressure changes in the stomach. The pressure sensor proposed in this invention has a passive wireless LC resonant sensing mechanism, which can realize real-time sensing and wireless transmission of local pressure signals in the stomach without the need for an internal power supply, reducing the device size and system complexity.

The invention discloses a gastric-soluble fiber material applied to infant and pet supplies and a preparation method of the gastric-soluble fiber material. The gastric-soluble fiber material comprises the following components in parts by weight: 100 parts of polymethacrylate; 5-10 parts of a plasticizer; due to the solubility of the gastric-soluble fiber material in a gastric acid environment, the products made of the gastric-soluble fiber material and applied to various infants and pets have necessary solubility, and when the products are possibly bitten, torn and damaged by the infants or pets, the products can not be damaged by the infants or pets. When the gastric juice is completely dissolved in the stomach, the gastric-soluble fiber material can react with hydrochloric acid in the gastric juice after a product made of the gastric-soluble fiber material generates fragments or the fiber body serving as a filler leaks and is eaten by mistake, so that the gastric-soluble fiber material is gradually dissolved into a flocculent or gelatinous state and is finally completely dissolved in the stomach environment; the intestinal obstruction condition caused by aggregation of common material fragments or fibers serving as fillers in intestines and stomachs can be avoided, and the safety of various infant and pet supplies can be remarkably improved.

The present disclosure relates to a taste-masking microcapsule composition. The composition comprises a core portion encapsulated by a shell portion. The core portion comprises an active pharmaceutical ingredient (API) and one or more excipients. The shell portion comprises a hydrophobic matrix and a pH-responsive material. The microcapsule compositions prevent API release at the more neutral pH levels in the oral cavity, but upon exposure to pH levels of the stomach, the pH-responsive material becomes soluble thereby permitting release of the API.