73 results about "Helicobacter" patented technology

The invention discloses a compound microbial agent for reducing the cadmium content of brown rice and application of the compound microbial agent. Belongs to the technical field of agricultural microorganisms. The compound microbial agent is prepared from herbaceous spirillum, stenotrophomonas and coxakia, the herbaceous spirillum is herbaceous spirillum R3, and the preservation number of the herbaceous spirillum is CCTCC (China Center For Type Culture Collection) NO: M 20231757; the stenotrophomonas is stenotrophomonas R5, and the preservation number of the stenotrophomonas is CCTCC (China Center For Type Culture Collection) NO: M 20231758; the coxakia is coxakia P1-4, and the preservation number of the coxakia is CCTCC (China Center For Type Culture Collection) NO: M 20231759. Compared with the prior art, the compound microbial agent disclosed by the invention has the beneficial effects that the compound microbial agent disclosed by the invention can reduce the content of cadmium in brown rice, so that farmland soil polluted by light and medium cadmium can be repaired and produced at the same time, and the edible safety of agricultural product rice is ensured.

The invention provides a probiotic composition for inhibiting helicobacter pylori as well as a probiotic agent and application thereof, and belongs to the technical field of probiotic functional products. The probiotic composition is prepared from the following components in parts by weight: 0.05 to 2 parts of a pediococcus pentosaceus strain A21358, 0.01 to 1.5 parts of a plant lactobacillus strain A21136, 0.05 to 1.5 parts of a lactobacillus rhamnosus strain A21149 and 0.03 to 1.2 parts of a lactobacillus reuteri strain A21325. The probiotic agent comprises the probiotic composition, resistant dextrin, xylooligosaccharide, erythritol, inulin, fructo-oligosaccharide, hericium erinaceus powder, fucoidin and at least one fruit powder selected from grape powder, passion fruit powder and kiwi fruit powder, wherein the specific weight parts of the resistant dextrin, the xylooligosaccharide, the erythritol, the inulin, the fructo-oligosaccharide, the hericium erinaceus powder, the fucoidin and the at least one fruit powder are selected from grape powder, passion fruit powder and kiwi fruit powder. The probiotic agent has the effect of inhibiting helicobacter pylori, and a new thought is provided for clinical related auxiliary treatment of helicobacter pylori infection.

The invention relates to a nano bismuth agent for preventing and / or treating gastritis infection as well as a preparation method and application thereof, the preparation method comprises the following steps: respectively dissolving soluble bismuth salt and a sulfur-containing compound, mixing, and reacting to obtain the nano bismuth agent after the reaction is finished, the sulfur-containing compound is any one or a combination of at least two of thioamino acid, vitamin B1, thioacetamide, sodium sulfide, sodium thiosulfate, bovine serum albumin, whey protein, ovalbumin or metallothionein. The prepared nano bismuth agent has efficient antibacterial performance, shows an excellent curative effect which is two orders of magnitude higher than that of an existing bismuth complex on clinically separated drug-resistant helicobacter pylori, and does not further induce increase of drug resistance of the helicobacter pylori.

The invention belongs to the field of biological medicine, and particularly relates to an anti-inflammatory and anti-helicobacter pylori compound separated from agilawood and a preparation method thereof. The method comprises the following steps: by taking the agilawood corasta as a raw material, carrying out reflux extraction with ethanol, extracting with petroleum ether to remove volatile components, separating and purifying by adopting various chromatographic technologies such as silica gel column chromatography, reversed-phase column chromatography and semi-preparative HPLC (High Performance Liquid Chromatography) to obtain a monomeric compound, and identifying the structure of the monomeric compound by adopting spectroscopy methods such as ultraviolet, high-resolution mass spectrometry and nuclear magnetic resonance. The structure of a compound 1 is identified as a new 2-(2-phenethyl) chromone dimer, and the compound 1 is named as aquicrasone V. The invention further discloses a preparation method of the compound 1. A biological activity test verifies that the compound has relatively strong anti-inflammatory activity and anti-helicobacter pylori activity.

The invention provides an innovative dual-mode detection method based on a dipeptide nano framework (DNPs), which is used for efficiently detecting helicobacter pylori. According to the method, firstly, a DNPs material formed by chelating dipeptide (Trp-Phe) and zinc ions (Zn (II)) is synthesized, and the material is decomposed along with the increase of the pH value in an alkaline environment, so that the Zn (II) is released; then, urea is hydrolyzed under the catalysis of urease to generate ammonia, so that the pH value of the solution is increased, and the decomposition of DNPs and the release of Zn (II) are further promoted. By utilizing an electrochemical detection mode, real-time analysis on urea and urease is realized by monitoring an electrochemical signal of Zn (II); meanwhile, in combination with the fluorescence characteristics of DNPs, the concentration of urea and urease is indirectly and quantitatively analyzed by monitoring the fluorescence intensity change. The dual-mode detection method combines the advantages of electrochemistry and fluorescence detection, has high sensitivity and real-time performance, provides an effective means for accurate detection of helicobacter pylori, and shows a wide application prospect in clinical diagnosis and sensing technologies.

The application provides a human Helicobacter pylori detection method and kit based on the nature of four-strand DNA oxidoreductase. The method uses isothermal amplification technology, amplifies the genomic fragment containing the four-strand DNA sequence in the human Helicobacter pylori genome, and realizes rapid and visual detection of the human Helicobacter pylori by adding hematin and oxidoreductase substrate for color reaction.

The application discloses a degradable gemini morpholine quaternary ammonium salt. The application further discloses a preparation method of the degradable gemini morpholine quaternary ammonium salt, comprising the following steps: S1, performing N-alkylation reaction on morpholine and halogenated alkane to obtain N-alkyl morpholine; S2, performing reaction on substance A and halogenated acetyl halide to obtain substance B; S3, continuously performing N-alkylation reaction on the N-alkyl morpholine and the substance B to obtain the degradable gemini morpholine quaternary ammonium salt. The application further discloses application of the degradable gemini morpholine quaternary ammonium salt in a bactericide and in preparation of a medicine for treating helicobacter pylori infection. The gemini morpholine quaternary ammonium salt has a good effect of killing helicobacter pylori; the gemini morpholine quaternary ammonium salt can be degraded in an alkaline environment, can avoid drug resistance of helicobacter pylori to the gemini morpholine quaternary ammonium salt, and can make the degradation product be rapidly discharged out of the body.

The present application relates to the technical field of Raman spectrum detection, and in particular to a stomach H. pylori infection detection method based on Raman spectrum. The method performs Raman spectrum detection on a gastric juice sample to obtain a Raman spectrum curve; a healthy Raman spectrum curve of a healthy gastric juice sample is obtained and constructed into a healthy sample spectrum library; according to the Raman intensity difference and waveform distribution similarity of each healthy Raman spectrum curve in the healthy sample spectrum library with other healthy Raman spectrum curves in a specified wavelength range, a representative weight of each healthy Raman spectrum curve is obtained; according to the Raman intensity distribution similarity of the Raman spectrum curve of the current patient with each healthy Raman spectrum curve in the specified wavelength range and the representative weight of each healthy Raman spectrum curve, the infection degree of the current patient is obtained, and it is determined whether the current patient is infected with H. pylori. The present application effectively improves the preparedness and universality of H. pylori detection by obtaining the infection degree.

This invention belongs to the field of probiotic technology, specifically relating to a probiotic for combating Helicobacter pylori infection and its application. The probiotic is Limosilactobacillus reuteri ZKAW05, derived from Tibetan yak milk residue, with the preservation number GDMCC NO: 65682. This probiotic exhibits good acid resistance, bile salt resistance, and Helicobacter pylori inhibition. After being cultured in an inducible culture medium, it is used to prepare probiotic powders, capsules, or tablets for combating Helicobacter pylori infection. It can maintain good probiotic activity in the gastrointestinal tract and is used to prevent or alleviate Helicobacter pylori infection in the oral cavity, gastrointestinal tract, and other sites.

The embodiment of the present specification provides an antibody or antigen binding fragment binding to Helicobacter pylori antigen protein urease, the antibody or antigen binding fragment comprising a heavy chain variable region and a light chain variable region. Wherein, the heavy chain variable region comprises CDRH1 of an amino acid sequence as shown in SEQ ID NO: 2, CDRH2 of an amino acid sequence as shown in SEQ ID NO: 3 and CDRH of an amino acid sequence as shown in SEQ ID NO: 4. The light chain variable region comprises CDRL1 of an amino acid sequence as shown in SEQ ID NO: 6, CDRL2 of an amino acid sequence of DTS and CDRL3 of an amino acid sequence as shown in SEQ ID NO: 7. The antibody or antigen binding fragment has the characteristics of high purity, high specificity and sensitivity. The embodiment of the present specification also provides related application of the antibody or antigen binding fragment binding to Helicobacter pylori antigen protein urease.

The invention relates to the technical field of microorganisms, in particular to a metagen for inhibiting helicobacter pylori infection and a preparation method of the metagen. The metagen is prepared by culturing the plant lactobacillus HYProbio-Y4, the preservation number of the plant lactobacillus HYProbio-Y4 is CGMCC (China General Microbiological Culture Collection Center) No.35968, and the metagen has the capability of inhibiting the activity of helicobacter pylori and urease in vitro; and the urease inhibitor can tolerate extreme temperature and pH, and can maintain high urease inhibition activity under the conditions that the temperature is 37-60 DEG C and the pH is 2-11.

The invention discloses recombinant bacteriophage lyase and application thereof. The amino acid sequence of the recombinant bacteriophage lyase E8-3 is as shown in SEQ ID NO: 43, and an in-vitro minimum inhibitory concentration experiment shows that the recombinant bacteriophage lyase E8-3 has a bacteriostatic effect on helicobacter pylori and acinetobacter baumannii, and particularly has a wide application prospect in the development of anti-helicobacter pylori drugs.

The utility model relates to the technical field of waste gas treatment devices for detectors, in particular to a waste gas treatment device for a helicobacter pylori detector, which is characterized in that inactivated gas is decomposed by starting a decomposition mechanism, and when impurities in a filter plate of a filter mechanism are saturated, a gas supply mechanism is restarted to supply gas to the filter plate of the filter mechanism; a filtering plate of the filtering mechanism is subjected to back flushing cleaning, impurities discharged from the filtering plate of the filtering mechanism are collected and discharged through a second discharging mechanism, and the practicability of the equipment is improved; comprising a supporting mechanism; the device further comprises an air supply mechanism, a filtering mechanism, a decomposing mechanism, a first discharging mechanism and a second discharging mechanism, the air supply mechanism, the filtering mechanism and the decomposing mechanism are all installed in the supporting mechanism, the filtering mechanism is located in the middle of the air supply mechanism, the decomposing mechanism is located on the upper portion of the air supply mechanism, and the first discharging mechanism is installed on the supporting mechanism. The second discharging mechanism is installed in the supporting mechanism and located below the air supply mechanism.

The invention provides an oral care composition for inhibiting helicobacter pylori and a preparation method of the oral care composition. The oral care composition comprises glycerin, xylitol, erythritol, thymol clathrate, garlic extract clathrate, propolis extract, lactoferrin, disodium ethylene diamine tetraacetate, menthol, potassium sorbate and purified water. The thymol clathrate compound is obtained by carrying out clathration on thymol through beta-cyclodextrin. The garlic extract clathrate compound is obtained by clathrating a garlic extract with beta-cyclodextrin. According to the oral care composition provided by the invention, the helicobacter pylori in the oral cavity can be effectively inhibited through reasonable proportioning of various components, so that the risks of ozostomia and stomach reinfection are reduced.

The application discloses application of sea cucumber saponins and / or sea cucumber saponin derivatives in anti-helicobacter pylori products. The application specifically discloses application of sea cucumber total saponins, sea cucumber saponin monomers, disaccharide-removed products of the sea cucumber saponin monomers, tetrasaccharide-removed products of the sea cucumber saponin monomers, and desulfurized products of the sea cucumber saponin monomers in anti-helicobacter pylori products. The application also discloses preparation methods of the sea cucumber total saponins, the sea cucumber saponin monomers, the disaccharide-removed products of the sea cucumber saponin monomers, the tetrasaccharide-removed products of the sea cucumber saponin monomers and the desulfurized products of the sea cucumber saponin monomers.

The application relates to the technical field of biological detection, and particularly discloses a rapid detection kit for Helicobacter pylori and an application method thereof; the kit comprises a sample processing liquid, an antigen pre-enrichment particle suspension and an immunochromatography test paper card; the sample processing liquid comprises an antigen-induced release system, a composite lysis system, a matrix interference blocking system and a chromatography promoter; the antigen pre-enrichment particle is a magnetic nanoparticle with an anti-Helicobacter pylori antibody coupled on the surface; and the immunochromatography test paper card is provided with a first detection line, a second detection line and a quality control line on a nitrocellulose membrane in sequence. The antigen is mildly and efficiently released through the antigen-induced release system, the bacterial cell wall is synergistically lysed through non-ionic and anionic surfactants, the interference substance is blocked through a double mechanism of a protein blocking agent and a metal ion chelating agent, the low-abundance antigen is enriched through the magnetic nanoparticle, and the sample effectiveness is monitored through the second detection line.

This application relates to a label-free immunosensor for Helicobacter pylori, its preparation method, and its application. The method involves directly incubating the Helicobacter pylori multivalent epitope antigen FvpE on a modified electrode, eliminating the need for hybridization labeling during the preparation of the label-free immunosensor. This simplifies the preparation process, making it simple and easy to operate. Furthermore, the prepared label-free immunosensor can directly detect Helicobacter pylori in samples, greatly simplifying the detection process and reducing detection time. Simultaneously, the prepared label-free immunosensor can detect polyclonal antibodies anti-Hp and different antibody genotypes such as CagA, UreA, UreB, and VacA, and can simultaneously detect multiple cytotoxins or virulence factors. This improves the universality of the label-free immunosensor, thereby reducing workload, shortening detection time, and lowering detection costs.

This invention relates to the extraction method and application of total extracts and compositions of *Helicobacter pylori* (Northern Green Dragon Leaf) medicinal materials, belonging to the field of traditional Chinese medicine extraction and chemical separation. To address the problems of high dependence, addiction, and significant adverse reactions of commonly used clinical anti-Helicobacter pylori drugs, the extraction method is as follows: *Helicobacter pylori* is weighed, soaked in ethanol (volume concentration), extracted, and the extracts are combined, the solvent is recovered, and the mixture is freeze-dried to obtain the total extract of *Helicobacter pylori*. The total extract is dissolved in water, and eluted with 20% ethanol using a chromatographic column to obtain the composition of *Helicobacter pylori*. The total extract and composition of *Helicobacter pylori* are used as active ingredients in drugs for treating *Helicobacter pylori*-positive gastric ulcers. Both exhibit significant antibacterial effects, low dependence and addiction, and no adverse reactions.

The application belongs to the technical field of medicine, and particularly relates to a compound montmorillonite particle for treating Helicobacter pylori infection and a preparation method thereof. The compound montmorillonite particle for treating Helicobacter pylori infection comprises A component and B component, wherein the A component is prepared from the following raw materials according to weight fractions: montmorillonite 50-65 parts; filler a 5-15 parts; binder a 0.1-1.5 parts; disintegrant 2-7 parts; the B component is prepared from the following raw materials according to weight fractions: amoxicillin 5-10 parts; rifabutin 0.2-0.5 parts; filler b 4-15 parts; binder b 1-6 parts; disintegrant 2-7 parts. The compound montmorillonite particle for treating Helicobacter pylori infection provided by the application has no drug resistance problem, and improves the compliance of patients with dysphagia and children to drug administration; and the application further provides a preparation method thereof, which is simple to operate and stable in process.

The application discloses a sulfonamide compound, a preparation method and application thereof. The compound can selectively antagonize a human and mouse NOD1 signal path, can inhibit secretion of inflammatory cytokines, and can be used for treating inflammatory diseases, in particular, gastritis caused by helicobacter pylori infection.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus rhamnosus A25040 with an antibacterial function as well as a preparation and application of the lactobacillus rhamnosus A25040. The lactobacillus rhamnosus A25040 provided by the invention has the advantages that the lactobacillus rhamnosus A25040 can be used for treating enteropathogenic bacteria, gastrointestinal pathogenic bacteria and oral pathogenic bacteria; particularly, the antibacterial and bactericidal effects on escherichia coli, helicobacter pylori, staphylococcus aureus, fusobacterium nucleatum, porphyromonas gingivalis, streptococcus mutans, streptococcus gordoni, streptococcus sanguis, streptococcus mitis, streptococcus suvidensis subspecies and streptococcus suvidensis subspecies are relatively strong; active substances secreted by the strain have good thermal stability, enzyme tolerance and gastrointestinal fluid tolerance, and the strain shows excellent oxidation resistance. The lactobacillus rhamnosus A25040 disclosed by the invention has broad-spectrum bacteriostasis and oxidation resistance, does not have hemolysis capacity, can be widely applied to functional food development, and has important application value in the field of biological medicines and daily chemical products.

The invention relates to the technical field of biological medicines, in particular to an anti-human helicobacter pylori fully-humanized monoclonal antibody as well as a preparation method and application thereof. The monoclonal antibody comprises one or more of a 4H1-A + 4 lambda 1-25 antibody, a 4H1-A + 4 lambda 1-6 antibody and a 4H1-A + 4 lambda 1-21 antibody; wherein the 4H1-A + 4 lambda 1-25 antibody comprises a 4H1-A heavy chain variable region and a 4 lambda 1-25 light chain variable region; the 4H1-A + 4 lambda 1-6 antibody comprises a 4H1-A heavy chain variable region and a 4 lambda 1-6 light chain variable region; the 4H1-A + 4 lambda 1-21 antibody comprises a 4H1-A heavy chain variable region and a 4 lambda 1-21 light chain variable region. According to the invention, the high-affinity human helicobacter pylori infection-resistant full-human monoclonal antibody is screened through a specific screening method after in-vitro activation of human memory B cells in a laboratory, and an important basis is provided for detection, neutralization and treatment of human helicobacter pylori.

The invention belongs to the technical field of microorganisms, and particularly relates to recombinant lactobacillus reuteri with helicobacter pylori resistance as well as construction and application of the recombinant lactobacillus reuteri. The recombinant lactobacillus reuteri is engineered to express a gram-negative bacillus outer membrane penetrating peptide and a helicobacter pylori bacteriophage HP30 splitting system protein Artilysin 2. The recombinant lactobacillus reuteri can inhibit the growth of helicobacter pylori and relieve GES-1 cell inflammation and mouse gastric mucosa inflammation induced by helicobacter pylori ATCC43504, and compared with a wild strain, the recombinant lactobacillus reuteri remarkably improves the helicobacter pylori resisting effect. In addition, the recombinant lactobacillus reuteri can tolerate gastric acid of a mouse and is colonized in gastric mucosa of the mouse, the purpose of remarkably resisting helicobacter pylori by single probiotics is achieved, meanwhile, a new treatment thought is provided for treatment of helicobacter pylori, and a new probiotic therapy is created for treatment of helicobacter pylori.

The utility model provides a helicobacter pylori petri dish with a porous design, which comprises a shell and a petri dish, the petri dish is rotatably arranged in the shell, a plurality of culture ring cavities with different diameters are coaxially arranged on the petri dish, a semicircular cover plate is coaxially and fixedly arranged on one side above the shell, and the semicircular cover plate is coaxially and fixedly arranged on the other side above the shell. The radius of the semicircular cover plate is the same as that of the shell, a plurality of arc cover plates corresponding to the culture ring cavities are coaxially and flexibly mounted on one side of the semicircular cover plate, creases are arranged at the joints of the arc cover plates and the semicircular cover plate, and the culture dishes are located below the semicircular cover plate and the arc cover plates. The culture dish is rotationally connected with the semicircular cover plate and the arc cover plate; due to the integral arrangement, the helicobacter pylori can be cultured in a classified mode, a user can open and close the sealing cover with one hand conveniently, and the helicobacter pylori culture box is more convenient to use.

This invention provides a novel use of a traditional Chinese medicine composition for preparing drugs or health products for treating or preventing Helicobacter pylori infection, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition of this invention consists of Polygonum multiflorum, Aloe vera, Cassia tora seed, Ginseng, Lycium barbarum fruit, Donkey-hide gelatin, Citrus aurantium fruit, and Atractylodes macrocephala, and has the effects of nourishing Yin and replenishing Qi, clearing turbidity and promoting bowel movement. The Helicobacter pylori strain of this invention has significant inhibitory and bactericidal effects in vitro, effectively inhibiting Helicobacter pylori in rats, and has positive clinical efficacy in treating Helicobacter pylori infection. It can reduce the use of antibiotics, thereby reducing the drug resistance rate of Helicobacter pylori, with high safety and few toxic side effects, and has broad application prospects and positive clinical significance.

The invention provides a corn protein active peptide for inhibiting adhesion of helicobacter pylori and application of the corn protein active peptide, and belongs to the technical field of corn protein active peptides. The corn protein active peptide with the helicobacter pylori adhesion inhibiting effect, provided by the invention, comprises at least one of corn protein active peptides of which the amino acid sequences are VPYPR, QWGAP and GHIWR. The corn protein active peptide provided by the invention has a remarkable helicobacter pylori adhesion inhibition effect, and the helicobacter pylori adhesion inhibition activities of the three polypeptides VPYPR, QWGAP and GHIWR are respectively 42.17 + / -1.69%, 26.93 + / -2.14% and 28.67 + / -1.07% under the concentration of 4mg / mL.

The invention relates to the field of functional food and natural product chemistry, in particular to a dietary therapy formula for repairing gastric mucosa and inhibiting helicobacter pylori and a preparation method of the dietary therapy formula. According to the formula, astragalus polysaccharide and 3-hydroxy-4-methoxyphenylacetamide which are modified by a glycyrrhizic acid-amino acid deep eutectic system are used as main components, and natural auxiliaries such as Chinese yam extract, lycium barbarum polysaccharide, pericarpium citri reticulatae flavone, maltooligosacharide and honey powder are used as auxiliary components. Hydrogen bond rearrangement and intercalation structure optimization of the astragalus polysaccharide are realized through deep eutectic modification, and the stability and adhesiveness of the astragalus polysaccharide in a gastric acid environment are remarkably improved; the 3-hydroxy-4-methoxyphenylacetamide can specifically inhibit the activity of helicobacter pylori urease and block the adhesion of the helicobacter pylori urease, so that the dual effects of repairing and bacteriostasis are realized. The formula is simple in preparation process and high in safety, and the obtained product is superior to a contrast in the aspects of gastric mucosa repair rate, bacteriostasis rate and acid resistance, and has a good dietary therapy application prospect.

The invention relates to the technical field of Raman spectrum detection, in particular to a stomach helicobacter pylori infection detection method based on a Raman spectrum. The method comprises the following steps: performing Raman spectrum detection on a gastric juice sample to obtain a Raman spectrum curve; healthy Raman spectrum curves of healthy gastric juice samples are obtained to construct a healthy sample spectrum library, and the healthy Raman spectrum curves in the healthy sample spectrum library are analyzed according to the Raman intensity difference and waveform distribution similarity condition of each healthy Raman spectrum curve and other healthy Raman spectrum curves in a specified wavelength range; obtaining a representative weight of each healthy Raman spectrum curve; according to the Raman intensity distribution similarity condition of the Raman spectrum curve of the current patient and each healthy Raman spectrum curve in the specified wavelength range and the representative weight of each healthy Raman spectrum curve, the infection degree of the current patient is obtained, and whether the current patient is infected with the helicobacter pylori or not is judged. By acquiring the infection degree, the preparation and universality of helicobacter pylori detection are effectively improved.

The invention relates to the technical field of biology, in particular to a construction method and application of a helicobacter pylori luciferase bacterial strain, the helicobacter pylori luciferase bacterial strain is obtained by introducing a Nanoluc gene into a helicobacter pylori genome, and the bacterial strain can efficiently express luciferase. The fluorescent probe can interact with a synthetic substrate furimazine to initiate lasting and bright bioluminescence, can be directly used for living body imaging, and is used for animal model construction and vaccine and therapeutic drug evaluation in the helicobacter pylori vaccine research and development process. Animal experiments prove that the helicobacter pylori luciferase strain interacts with furazine in the stomach of a living animal to emit bright and lasting bioluminescence, and is used for observing sustainable infection of the living animal. The method lays a foundation for further evaluation of helicobacter pylori vaccine protectiveness, and plays an important role in development and application of prevention and treatment vaccines and drugs.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for inhibiting helicobacter pylori and a preparation method and application thereof. Comprising the following raw materials: honeysuckle, dandelion, dendrobium officinale, chrysanthemum, clove and hericium erinaceus. The preparation method comprises the following steps: taking honeysuckle, dandelion, dendrobium officinale, chrysanthemum, clove and hericium erinaceus, extracting, concentrating and drying. The honeysuckle, the dandelion and the chrysanthemum in the whole formula have the effects of clearing damp-heat and removing toxins; dendrobium officinale and hericium erinaceus protect the stomach, complement each other in compatibility, dispel turbid toxins, strengthen healthy qi and jointly prevent and treat Hp, the whole formula combines cold and warm, honeysuckle and dandelion are cold in nature, clove is warm in nature, and it is avoided that the stomach is injured by bitter cold; the antibacterial effect of the honeysuckle and the clove is synchronous with the repairing effect of the dendrobium officinale and the hericium erinaceus, so that the traditional Chinese medicine composition has a remarkable effect of resisting helicobacter pylori.