41 results about "Gastritis" patented technology

The invention discloses a long-acting pellet suitable for gastric absorption and a preparation method of the long-acting pellet. The long-acting pellet is prepared from the following components in parts by mass: 0.01-1 part of a medicine, 1-2.5 parts of a filler, 0.2-0.7 part of a modified pore-foaming agent mixture, 1-2.5 parts of an improved adhesive mixture and 0.1-0.7 part of an improved sonokinetic response agent. Wherein the modified pore-foaming agent mixture is prepared from a modified pore-foaming agent and glycosylated saponin, the modified pore-foaming agent is prepared by mixing a pore-foaming agent and seleno-amino acid according to a mass ratio of 4: 1, the improved adhesive is mixed with the adhesive through BHP-SH, and ionic crosslinking is performed by using CaCl2 to form a covalent ion dual network, so that the stomach adhesiveness is enhanced; the sonokinetic response agent is improved by the coated poria cocos extract, and the long-acting pellet is prepared by adopting a wet granulation method or a fluidized bed method, has the characteristics of slow release, long acting, targeted stomach absorption and responsive drug release, and is suitable for treating stomach diseases such as gastritis.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating or improving prostate diseases and stomach diseases, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials: Chinese lobelia, tripterygium wilfordii, selfheal, dandelion, lophatherum gracile, hydrocotyle verticillata and liquorice. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility and synergistic in efficacy, can treat prostate diseases such as chronic prostatitis and benign prostatic hyperplasia and stomach diseases such as chronic gastritis and gastric ulcer at the same time by taking a treatment method of clearing away heat and toxic materials, promoting diuresis and treating stranguria, regulating qi and harmonizing stomach and removing stasis and diminishing swelling, has the advantages of definite curative effect, high safety, low recurrence rate, convenience in taking and the like, and is suitable for clinical popularization.

This invention discloses a Zhishu Yangwei tablet for chronic gastritis and its granule dry-compression tableting process, relating to the field of traditional Chinese medicine preparation technology. The Yangwei tablet is made from the following raw materials in parts by weight: Codonopsis pilosula 35-45 parts, stir-fried Atractylodes macrocephala 18-22 parts, Poria cocos 18-22 parts, Glycyrrhiza uralensis 8-12 parts, Amomum villosum 18-22 parts, Lindera strychnifolia 18-22 parts, Salvia miltiorrhiza 45-55 parts, roasted Aucklandia lappa 18-22 parts, Paeonia lactiflora 18-22 parts, stir-fried Citrus aurantium 18-22 parts, Magnolia officinalis 28-32 parts, Lilium brownii 35-45 parts, and stir-fried chicken gizzard lining 18- 22 parts, dried plum 45-55 parts, Coptis chinensis 8-12 parts, hawthorn 35-45 parts, magnesium stearate 5-7 parts, sucrose 28-32 parts; This invention uses low-temperature dynamic extraction technology to replace the traditional high-temperature decoction process, effectively reducing the decomposition loss of heat-sensitive active ingredients such as tanshinone IIA and ursolic acid, and improving the bioavailability of the drug. It also uses membrane concentration and spray drying technology to replace the traditional atmospheric pressure concentration and oven drying process, shortening the production cycle, reducing energy consumption, and avoiding the degradation of active ingredients caused by prolonged heating of materials.

The invention relates to the technical field of traditional Chinese medicine compositions and preparations, in particular to a traditional Chinese medicine composition for treating liver depression and spleen deficiency type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from codonopsis pilosula, rhizoma atractylodis macrocephalae stir-fried with bran, radix bupleuri, stir-fried radix paeoniae alba, pericarpium citri reticulatae, fructus aurantii stir-fried with bran, ginger processed pinellia, radix salviae miltiorrhizae, medicated leaven, stir-fried endothelium corneum gigeriae galli and fingered citron according to The traditional Chinese medicine composition is based on the theory of inhibiting wood and supporting soil in traditional Chinese medicine, and all the components have a synergistic effect and have the effects of soothing the liver, relieving depression, strengthening the spleen and harmonizing the stomach. Animal experiments prove that the traditional Chinese medicine composition provided by the invention can significantly improve the gastric emptying rate and the small intestine propulsion rate of a chronic gastritis model, and can down-regulate the gene expression of gastric mucosa intestinal metaplasia related markers CDX2 and MUC2.

This invention provides a deep learning-based method for fine-tuning the general representation of gastritis pathological images. The method includes: obtaining a pathological feature extraction network based on a first pathological image and a training strategy; obtaining a pathological evolution manifold based on the pathological feature extraction network and training a lesion reversal simulator to obtain a pathological evolution base model; obtaining a downstream task classification head and a second pathological image; freezing the parameters of the pathological evolution base model and inserting cue vectors into the pathological feature extraction network; training the cue vectors and the downstream task classification head using the second pathological image to obtain a fine-tuned model; inputting a third pathological image into the fine-tuned model, obtaining analysis results, and using the pathological evolution base model to generate lesion deviation data for the third pathological image. This invention achieves efficient adaptation to downstream tasks under small sample conditions while not forgetting the internalized disease continuity evolution patterns of the model.

The present invention provides a tegoprazan sugar acid salt and a preparation method therefor, the salt being pharmaceutically usable for gastroesophageal disease, gastroesophageal reflux disease, gastritis, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, non-erosive reflux disease (NERD) and the like. The tegoprazan sugar acid salt of the present invention has excellent water solubility and stability of tegoprazan, and thus can be particularly useful as a pharmaceutical injection preparation.

The present invention relates to an antisense oligonucleotide targeting an interleukin 4 receptor and the use thereof. The antisense oligonucleotide (ASO) molecule has a length of 16-22 bases and is specifically paired with a specific region of a target gene (interleukin 4 receptor). The ASO is used for treating diseases associated with IL-4Rα, which includes, but is not limited to, asthma (including eosinophilic asthma), atopic dermatitis, eosinophilic esophagitis, sinusitis, nasal polyps, prurigo nodularis, urticaria, chronic obstructive pulmonary disease, bullous pemphigoid, pruritus, and gastritis.

The invention is suitable for the technical field of medicine, and provides a stomach medicine capsule and a preparation method thereof, the stomach medicine capsule is prepared from 20-30 parts of Chinese angelica, 7-11 parts of phoenix-tail fern, 15-19 parts of radix berberidis, 5-9 parts of radix aucklandiae, 2-4 parts of reed seed, 13-17 parts of sea snail and auxiliary materials; the preparation method comprises the steps of raw material pretreatment, ethanol reflux extraction, vacuum concentration, spray drying, mixing granulation, capsule filling and packaging. The traditional Chinese medicine raw materials in a specific proportion are screened, the synergistic effect of resisting inflammation and bacteria, regulating qi to relieve pain, nourishing blood and repairing, and relieving acid and protecting the stomach is achieved, and the problems that an existing stomach medicine is single in effect and large in side effect are solved; meanwhile, extraction and drying processes are optimized, the dissolution rate of effective components and the stability of the preparation are improved, and the traditional Chinese medicine composition is suitable for treating stomach diseases such as acute and chronic gastritis, gastric ulcer and hyperacidity, high in safety and suitable for long-term administration.

The invention relates to a traditional Chinese medicine preparation for treating gastritis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 40-50 parts of a traditional Chinese medicine composition, 10-15 parts of a sustained release agent, 25-32 parts of a filling agent and 3-8 parts of a flavoring agent, the slow release agent is modified carboxymethyl konjac glucomannan; the filling agent is cordyceps militaris polysaccharide and lactose; the flavoring agent is aspartame or sucralose. The sustained release agent is neohesperidin dihydrochalcone modified carboxymethyl konjac glucomannan, neohesperidin dihydrochalcone has the effect of inhibiting gastric acid secretion, and neohesperidin dihydrochalcone and the traditional Chinese medicine ingredient cuttlebone can synergistically play a role in preparing acid and jointly play a role in protecting gastric mucosa. Meanwhile, the cordyceps militaris polysaccharide has polysaccharide generality of thickening and stable film forming, and forms a compact network structure together with the modified carboxymethyl konjac glucomannan, and the obtained traditional Chinese medicine preparation has a good slow release effect.

The invention discloses substitutional tea with effects of preventing hypertension, hyperglycemia, hyperlipidemia and gastric cancer. The substitutional tea is prepared from the following raw materials in parts by mass: 0.8 to 1.2 parts of rhizoma zingiberis, 0.8 to 1.2 parts of poria cocos, 0.8 to 1.2 parts of cortex cinnamomi, 0.8 to 1.2 parts of pericarpium citri reticulatae, 0.3 to 0.7 part of liquorice root, 0.8 to 1.2 parts of rice, 0.8 to 1.2 parts of wheat, 0.08 to 0.12 part of radix ginseng and 0.08 to 0.12 part of folium perillae. The invention develops a tea substitute drink with a prevention effect aiming at the rejuvenation current situation of people with hypertension, hyperlipidemia, hyperglycemia and chronic gastritis. The tea substitute drink has the characteristics of being convenient to brew and convenient to produce, and is easy to use by consumers and easy to produce by manufacturers. The components are easy to absorb, and the prevention effect can be better achieved. Meanwhile, the product is clean and environment-friendly, the burden on the environment is reduced, and the cost performance is high. By adopting the concept of homology of medicine and food, the tea is suitable for people with hypertension, hyperlipidemia and chronic gastritis to drink daily and provides a new choice for preventing related diseases.

Provided herein are formulations for use in enteral tube feeding, that contain one or more whole food-based ingredients, mineral nutrients, small molecules, and / or large molecules, the combination of which is effective to bind bile acids when administered to a subject in need thereof. The combination of crafted ingredients for tube feeding reduce symptoms of gastroesophageal reflux, vomiting, abdominal pain, irregular stooling (diarrhea or constipation) and to reduce organ damage including pneumonia, pharyngitis, aspiration, esophagitis, gastritis and enteritis.

This invention relates to an antisense oligonucleotide targeting the interleukin-4 receptor and its applications. The antisense oligonucleotide (ASO) molecule is 16-22 bases in length and specifically pairs with a specific region of the target gene (interleukin-4 receptor). The ASO is used to treat diseases related to IL-4Rα, including but not limited to asthma (including eosinophilic types), atopic dermatitis, eosinophilic esophagitis, sinusitis, nasal polyps, nodular prurigo, urticaria, COPD, bullous pemphigoid, pruritus, and gastritis.

The invention provides application of hippophae rhamnoides extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking, and belongs to the technical field of biological medicine. The invention provides application of a sea-buckthorn extract or a product containing the sea-buckthorn extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking. The sea-buckthorn extract comprises sea-buckthorn fruit oil, sea-buckthorn seed oil and / or sea-buckthorn fruit pulp. The organ injury comprises alcoholic fatty liver, gastric mucosa injury or duodenum mucosa injury. The hippophae rhamnoides fruit extract (hippophae rhamnoides fruit pulp, hippophae rhamnoides fruit oil and hippophae rhamnoides fruit seed oil) and the hippophae rhamnoides fruit and Chinese wolfberry fruit composite primary pulp provided by the invention have the effects of promoting the repair of gastric mucosa and duodenal mucosa and further enhancing the immunity of gastrointestinal tracts, and can effectively prevent and / or treat gastritis, alcoholic fatty liver and duodenal mucosa injury caused by drinking; the traditional Chinese medicine composition can replace traditional medicine treatment and has the advantages of small side effect, economy, practicability, suitability for long-term administration and good compliance.

The invention provides a medicine containing hederagenin and application of the medicine in regulating and controlling lysozyme to block gastritis-cancer transformation, the interaction relation between hederagenin and a key target spot is preliminarily determined by combining the key target spot LYZ of gastric inflammation-cancer screened by early-stage bioinformatics and applying a molecular docking technology, and then verification is performed by applying in-vivo and in-vitro experiments. Results of research discover that the common component hederagenin of astragalus membranaceus-curcuma zedoary and the key target LYZ of the gastric inflammation-cancer have an interaction relationship, and in-vivo and in-vitro experiments prove that the hederagenin can regulate and control the key target LYZ of the gastric inflammation-cancer, so that a new foundation is laid for further screening of core medicine components and optimization of traditional Chinese medicine formulas. The research and development of effective drugs for preventing and treating early gastric cancer have important significance.

The invention discloses a traditional Chinese medicine composition for treating intestinal tract diseases, which is prepared from the following traditional Chinese medicines in parts by weight: 8-15 parts of selfheal, 20-40 parts of nacre mother of pearl, 5-10 parts of radix bupleuri, 3-8 parts of fried fructus aurantii, 3-8 parts of rhizoma cyperi, 6-12 parts of inula flower and 5-9 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition can be used for pertinently treating liver and gall stagnated heat, stomach qi reversal type bile reflux gastritis or gastroesophageal reflux disease, has the specific treatment effects of relieving inflammation, inhibiting local tissue angiogenesis and preventing precancerous lesions and / or canceration, and has good clinical significance.

The application discloses a sulfonamide compound, a preparation method and application thereof. The compound can selectively antagonize a human and mouse NOD1 signal path, can inhibit secretion of inflammatory cytokines, and can be used for treating inflammatory diseases, in particular, gastritis caused by helicobacter pylori infection.

The present application belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating fullness and application thereof. The traditional Chinese medicine composition comprises Chaihu, Baishao, Xinyinhua, Yujin, Taizishen, Wuzhimaotao, Fushen, Hehuanpi, Huazao, Jiguangxiang, Tanshang, Bamiaozha, Sharen, Baodoukou, Zixugeng, Lugen, Zhuzu, Dujiaojin, Chao'anyu, Busheye and Danshen. The traditional Chinese medicine composition has the effects of relieving depression and soothing the nerves, invigorating the spleen and tonifying qi, eliminating fullness and relieving distension, and follows the principles of 'treating the same disease with the same method' and 'treating the disease from the root'. The traditional Chinese medicine composition is in accordance with the principle of combination of monarch, minister, assistant and guide, has unique effects on chronic gastritis, functional dyspepsia and gastrointestinal neurosis of the type of liver depression and spleen deficiency, has no adverse reactions, is safe and effective, and is suitable for popularization and application.

The invention provides modified milk powder capable of relieving chronic gastritis as well as a preparation method and application of the modified milk powder. The modified milk powder disclosed by the invention has the total protein content of 16.5-30 g / 100g, the fat content of 1.0-26 g / 100g, the dietary fiber content of 0-15.0 g / 100g and the carbon-water content of 30-69 g / 100g. Moreover, the modified milk powder contains hericium erinaceus and / or an extract thereof and dried ginger and / or an extract thereof, the weight ratio of the sum of the hericium erinaceus and the extract thereof to the sum of the dried ginger and the extract thereof is 1: (0.2-4) according to the amount of dry matter, and the total content of the hericium erinaceus and / or the extract thereof and the dried ginger and / or the extract thereof in the modified milk powder is 0.1-2 g / 100 g. The modified milk powder can relieve chronic gastritis and improve gastric mucosal lesion.

The present invention provides a codonopsis pilosula nnannf particle solid beverage and a production method thereof, the codonopsis pilosula nnannf particle solid beverage is prepared by selecting genuine codonopsis pilosula nnannf, cleaning, extracting, concentrating and drying through modern equipment, taking crushed cane sugar, glucose, maltodextrin and an extract according to a ratio of 1: 2: 5: 2, mixing, granulating, drying, finishing and inspecting, and the codonopsis pilosula nnannf particle solid beverage is obtained. The particle solid beverage is convenient to take, appropriate in taste, easy to absorb and easy to preserve, a proper amount of the particle solid beverage is taken, the particle solid beverage is brewed with boiled water and stirred until being completely dissolved, and the particle solid beverage is taken after being cooled to be warm, can be taken for multiple times a day and is suitable for long-term application. According to the preparation method, the side effect of dryness of raw codonopsis pilosula nnannf is removed, the effects of harmonizing the stomach, strengthening the spleen, benefiting qi and nourishing blood are obviously enhanced, and the traditional Chinese medicine composition can be applied to clinical patients suffering from chronic gastritis, chronic nephritis, infantile diarrhea, anemia in the obstetrics and gynecology department, spleen and lung qi deficiency after radiotherapy and chemotherapy and the like in an auxiliary mode and is more suitable for the old, weak, infants, pregnant women and other people suffering from immunity deficiency.

Composition for use in a method for preventing the onset or treating the symptoms of gastritis in equines, said method comprising a step of administering a therapeutically effective amount of the composition to an equine, wherein the composition comprises: an amount of dehydrated sweet potato; an amount of β-glucan (BG) powder; an amount of dried St. John's wort (Hypericum perforatum) flowers; an amount of fenugreek seed powder (Trigonella foenum-grecum); an amount of carob pod powder (Ceratonia siliqua). IPC=A23K

The application discloses a long-acting hydrogen-releasing microsphere in the stomach and use of the microsphere as a drug in treatment of gastritis, and belongs to the field of pharmaceutical preparations and hydrogen treatment. The composition provided by the application is composed of a hydrogen production micro-particle as a core and a sustained-release agent composed of hydroxypropyl methyl cellulose and ethyl cellulose. By selecting specific components and processes, the microsphere has good floatability and long-acting hydrogen-releasing capacity. The microsphere can float in the gastric juice environment and gradually release hydrogen, so that the sustained anti-oxidation and anti-inflammatory effects are realized, and the microsphere is suitable for treatment of gastric inflammation.

The invention discloses application of a reagent of a circRNA marker for detecting gastric cancer diagnosis in preparation of a gastric cancer diagnosis product, and belongs to the field of biotechnology and molecular diagnosis. The circRNA marker is hsacirc0005265, the expression of the hsacirc0005265 in serum of a patient with gastric cancer is obviously up-regulated through verification, the area under a curve for independently diagnosing the gastric cancer can reach 0.853, the sensitivity is 0.75, the specificity is 0.88, and the circRNA marker also shows good identification ability when being used for distinguishing the gastric cancer from gastritis and distinguishing the gastric cancer from healthy people. The molecular marker is a gastric cancer diagnosis molecular marker which is high in sensitivity, high in specificity, non-invasive, stable, reliable and easy to clinically popularize, and solves the problems of low sensitivity and specificity, complicated operation of invasive examination, discomfort of patients and the like of a serum protein marker commonly used for gastric cancer diagnosis at present.

The invention discloses a paste dressing for invigorating spleen, replenishing qi and removing stagnation as well as a preparation method and application of the paste dressing. The active effective components of the paste dressing comprise the following components: lindera aggregata, radix angelicae, pepper, processed rhizoma typhonii, rhizoma zingiberis, ligusticum wallichii, elecampane and caulis spatholobi. The paste dressing disclosed by the invention has an excellent transdermal treatment effect through transdermal drug delivery, and has a good treatment effect on symptoms such as abdominal distension, abdominal distension of gastric mass diseases and constipation of patients with chronic gastritis in cooperation with a stone needle ironing therapy.

The present application relates to the field of traditional Chinese medicine, and particularly to a composition for treating chronic gastritis and application thereof, the composition is prepared from the following raw materials according to weight fraction: 8-12 parts of Fashanxia, 8-12 parts of Huangqin, 3-7 parts of Huanglian, 4-8 parts of Ganjiang, 12-18 parts of Taizishen, 12-18 parts of Baihuasheshecao, 12-16 parts of Banzhilian, 8-12 parts of E'zhu, 12-20 parts of Chaozhigu, 18-22 parts of Chaoquya, 18-22 parts of Chaomaiya, 8-12 parts of Yujin, 1-5 parts of Sanqi, 8-12 parts of Dazao and 3-8 parts of Zhigancao. The present application effectively solves the problems of lack of specific therapy and specific intervention target for reversing mucosal atrophy, intestinal metaplasia and other precancerous lesions in the prior art, provides a new idea for the mechanism research of CAG treatment by traditional Chinese medicine, and has important theoretical value and clinical conversion prospect for promoting the modernization of traditional Chinese medicine.

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of medicines for treating gastric precancerous lesions and inhibiting gastritis-cancer transformation. The traditional Chinese medicine composition is prepared from astragalus membranaceus, red ginseng, pseudo-ginseng, pericarpium citri reticulatae, bran-fried rhizoma atractylodis macrocephalae, rhizoma zingiberis, rhizoma pinelliae preparata, rhizoma coptidis, ovateleaf holly bark and honey-fried licorice root. The traditional Chinese medicine composition provided by the invention is good in safety, has double curative effects, not only can repair gastric mucosa injury, relieve inflammation, inhibit epithelial cell-mesenchymal transformation of gastric mucosa, improve gastric mucosa tissue lesion and block gastric'inflammation-cancer 'transformation, but also has a direct anti-gastric cancer effect, can inhibit invasion and metastasis of gastric cancer and promote apoptosis of gastric cancer cells, and has the effects of preventing and treating gastric cancer. A new drug choice is provided for blocking and reversing the malignant progress of gastric mucosa in a safe and effective traditional Chinese medicine within a stomach'inflammation-cancer 'time window, and the application prospect is wide.

The invention relates to the technical field of veterinary drugs, and particularly provides a traditional Chinese medicine composition for preventing and / or treating poultry glandular ventriculitis and promoting growth and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following medicines in parts by weight: 2-8 parts of radix sophorae flavescentis, 2-8 parts of rhizoma atractylodis, 2-8 parts of rheum officinale, 2-6 parts of rhizoma cyperi, 2-6 parts of pericarpium citri reticulatae, 2-6 parts of scorched hawthorn fruit, 1-5 parts of radix gentianae, 1-5 parts of cortex phellodendri, 1-5 parts of fructus aurantii, 1-4 parts of radix paeoniae alba, 1-4 parts of radix aucklandiae, 1-4 parts of betel nut and 1-5 parts of cortex magnoliae officinalis. The traditional Chinese medicine composition has the effects of eliminating dampness and detoxifying, invigorating spleen and replenishing qi, can effectively treat or prevent poultry glandular ventriculitis and related diseases, can promote the growth of poultry, and is low in cost.

The invention discloses compound oil tea for regulating spleen, stomach and intestinal tract and a preparation method thereof, and belongs to the technical field of food processing. The compound oil tea is prepared from soybeans, edible vegetable oil, honey, pumpkin seeds, phaseolus calcaratus, white hyacinth beans, peanuts, white sesame seeds, black sesame seeds and cotton white sugar according to a specific weight percentage, all the raw materials are medicinal and edible food materials or edible raw materials, and no additive is added. The formula is scientific and reasonable, all the raw materials have a synergistic effect, the functions of the spleen, the stomach and the intestinal tract can be effectively regulated, and various uncomfortable symptoms such as gastric ulcer, deficiency-cold in the spleen and the stomach, various gastritis, enteritis and digestive dysfunction are relieved; the product is safe, free of side effects, excellent in taste, long in shelf life, simple in preparation process, convenient for industrial production and popularization, suitable for long-term eating by various people, and especially suitable for people with weak spleen, stomach and intestinal functions.

The present application relates to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating chronic gastritis, a preparation method and application thereof. The traditional Chinese medicine composition comprises chicken gizzard suet, American ginseng and red sage root, and the mass ratio is 5-15:3-10:5-15. The traditional Chinese medicine composition comprises chicken gizzard suet, American ginseng, red sage root and cuttlebone, and the mass ratio is 5-15:3-10:5-15:10-25. The preparation method mainly comprises steps of alcohol extraction, water extraction and mixing. The traditional Chinese medicine composition has the comprehensive effects of invigorating the spleen and replenishing qi, nourishing yin and stomach, promoting digestion and removing stagnation, promoting blood circulation and removing blood stasis, and acid inhibition and mucus protection. The traditional Chinese medicine composition can effectively treat chronic gastritis, promote the repair of gastric mucosa, and is suitable for long-term conditioning and taking.

The present application relates to the technical field of experimental animal pathological model modeling, and more particularly to a glandular gastritis modeling agent, a preparation method and application thereof.The present application relates to a glandular gastritis modeling agent, which comprises a ZnO-OTA core and a mesoporous silica shell layer coated on the surface of the ZnO-OTA core; the ZnO-OTA core comprises amino zinc oxide nanoparticles and ochratoxin A.In the present application, the amino zinc oxide nanoparticles and ochratoxin A are combined through electrostatic adsorption, and then coated with mesoporous silica to form a core-shell structure; when applied to the construction of a broiler glandular gastritis pathological model, a stable and high-pathology-compliance glandular gastritis model can be established, the required time is short, the modeling effect is good, and a stable and high-pathology-compliance glandular gastritis model can be established within 21 days.

The application provides a premix for preventing and treating chicken gastritis, a preparation method and application thereof, and relates to the technical field of animal feed. Specifically, the premix comprises a composite probiotic microcapsule, a composite enzyme preparation, a functional excipient and a carrier; the functional excipient comprises a nano-modified silico-aluminate, a jerusalem artichoke powder, a curcumin microcapsule and vitamin E succinate; the composite probiotic microcapsule is prepared by drying a W / O / W emulsion, and the inner water phase of the W / O / W emulsion comprises a probiotic composite agent. The application realizes the prevention and treatment of chicken gastritis through a multi-target intervention strategy system based on the synergistic effect of bacteria and enzymes, and provides an efficient, safe and economical gastritis prevention and treatment premix through a three-fold synergistic mechanism of "toxin biodegradation-pathogenic bacteria inhibition-mucosal barrier repair", a three-section microcapsule embedding technology and a low-temperature solid-state activation process in the preparation method, and material modification and preparation engineering technology, and solves the compatibility problem of components innovatively.