85 results about "Gastritis" patented technology

A method based on a multi-task learning model comprises the following steps: acquiring and processing histopathological image data of gastritis through a data preparation and preprocessing step; feature extraction is performed by using a self-supervised learning pre-trained model, and image blocks are coded into high-dimensional feature vectors; and constructing a multi-task learning model, learning feature representation through a full connection layer module and an attention layer module, and outputting a classification result of each task. And carrying out model training and optimization by using an optimizer, adding multitask loss through a loss function, and dynamically adjusting the model performance. The trained model can automatically detect and grade gastritis, atrophy, acute activity, intestinal metaplasia and other pathological indexes, outputs a standardized evaluation result, and assists in pathological diagnosis. According to the method, a multi-task deep learning framework based on self-supervised learning pre-training is constructed, a traditional single-task modeling mode is broken through, deep learning framework design is driven through pathological index association, and accuracy and clinical practicability of non-neoplastic disease assessment of the stomach are remarkably improved.

The invention discloses lactobacillus reuteri LR69 capable of enhancing a gastric mucosal barrier and application, a product and a method thereof, and belongs to the technical field of microorganisms. The invention provides a lactobacillus reuteri LR69, and the preservation number of the lactobacillus reuteri LR69 is CGMCC (China General Microbiological Culture Collection Center) No.33731. The lactobacillus reuteri LR69 is a lactobacillus reuteri LR69. The invention also provides application of the strain in preparation of food with an auxiliary protection function on gastric mucosa, and / or food with an intestinal flora regulating function, and / or a product for relieving gastritis, and / or food with an immunity enhancing function, and / or a bacteriostatic agent. The invention further discloses a food with an auxiliary protection function on gastric mucosa, a food with an intestinal flora regulating function, a product for relieving gastritis, a food with an immunity enhancing function, a bacteriostatic agent and an in-vitro bacteriostasis method based on the strain. The lactobacillus reuteri LR69 disclosed by the invention can effectively assist in protecting gastric mucosa, regulating intestinal flora, relieving gastritis, enhancing immunity and realizing broad-spectrum bacteriostasis.

The invention discloses a long-acting pellet suitable for gastric absorption and a preparation method of the long-acting pellet. The long-acting pellet is prepared from the following components in parts by mass: 0.01-1 part of a medicine, 1-2.5 parts of a filler, 0.2-0.7 part of a modified pore-foaming agent mixture, 1-2.5 parts of an improved adhesive mixture and 0.1-0.7 part of an improved sonokinetic response agent. Wherein the modified pore-foaming agent mixture is prepared from a modified pore-foaming agent and glycosylated saponin, the modified pore-foaming agent is prepared by mixing a pore-foaming agent and seleno-amino acid according to a mass ratio of 4: 1, the improved adhesive is mixed with the adhesive through BHP-SH, and ionic crosslinking is performed by using CaCl2 to form a covalent ion dual network, so that the stomach adhesiveness is enhanced; the sonokinetic response agent is improved by the coated poria cocos extract, and the long-acting pellet is prepared by adopting a wet granulation method or a fluidized bed method, has the characteristics of slow release, long acting, targeted stomach absorption and responsive drug release, and is suitable for treating stomach diseases such as gastritis.

The invention relates to the technical field of biology, and discloses a soybean extract as well as an extraction method and application thereof. The extraction method of the soybean extract comprises the following steps: performing circulating freezing and thawing treatment on soybeans to obtain pretreated soybeans; putting the pretreated soybeans into a microwave reaction kettle, and carrying out primary microwave extraction; after the primary microwave extraction is finished, condensing gas in the microwave reaction kettle to obtain a soybean extract A; crushing soybeans, and mixing the crushed soybeans with deionized water to obtain soybean slurry; placing the soybean slurry in a microwave reaction kettle, introducing nitrogen into the microwave reaction kettle, and carrying out secondary microwave extraction; filtering the soybean slurry subjected to the secondary microwave extraction by using a ceramic membrane, and freeze-drying to obtain a soybean extract B; and mixing the soybean extract A and the soybean extract B to obtain the soybean extract. The treatment effective rates of the soybean extract on gastric ulcer and gastritis can reach 90.0% and 80.0% respectively, and the soybean extract has good gastric ulcer and gastritis treatment effects.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating or improving prostate diseases and stomach diseases, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials: Chinese lobelia, tripterygium wilfordii, selfheal, dandelion, lophatherum gracile, hydrocotyle verticillata and liquorice. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility and synergistic in efficacy, can treat prostate diseases such as chronic prostatitis and benign prostatic hyperplasia and stomach diseases such as chronic gastritis and gastric ulcer at the same time by taking a treatment method of clearing away heat and toxic materials, promoting diuresis and treating stranguria, regulating qi and harmonizing stomach and removing stasis and diminishing swelling, has the advantages of definite curative effect, high safety, low recurrence rate, convenience in taking and the like, and is suitable for clinical popularization.

The utility model relates to the technical field of traditional Chinese medicine pockets, and discloses a traditional Chinese medicine pocket for treating gastritis. The penetrating opening is formed in the front surface of the pocket body; the connecting assembly is fixedly connected to the outer side of the pocket body. According to the traditional Chinese medicine pocket for treating gastritis, the hidden buckles are clamped to the inner surfaces of the embedded buttons, the left connecting band and the right connecting band are connected to enable the pocket body to be tightly attached to the abdomen, the pocket is worn on the two shoulders through the elastic bands on the two sides, the hook-face magic stickers are pasted to the hook-face magic stickers through the loop-face magic stickers, and the left connecting band and the right connecting band are fixed to the front faces of the elastic bands; the pocket body can be prevented from sliding off to affect the hot compress effect; the medicinal material bag is heated through the heating bag, the absorption rate of the human body to medicinal materials is improved, the medicinal effect slowly and durably acts on the abdomen, the treatment purpose is achieved, moisture and sweat on the surface layer of the skin are rapidly absorbed through the arranged auxiliary fabric and instantly discharged out of the body through the exhaust holes, and therefore the skin around the hot compress is kept dry and comfortable.

This invention discloses a Zhishu Yangwei tablet for chronic gastritis and its granule dry-compression tableting process, relating to the field of traditional Chinese medicine preparation technology. The Yangwei tablet is made from the following raw materials in parts by weight: Codonopsis pilosula 35-45 parts, stir-fried Atractylodes macrocephala 18-22 parts, Poria cocos 18-22 parts, Glycyrrhiza uralensis 8-12 parts, Amomum villosum 18-22 parts, Lindera strychnifolia 18-22 parts, Salvia miltiorrhiza 45-55 parts, roasted Aucklandia lappa 18-22 parts, Paeonia lactiflora 18-22 parts, stir-fried Citrus aurantium 18-22 parts, Magnolia officinalis 28-32 parts, Lilium brownii 35-45 parts, and stir-fried chicken gizzard lining 18- 22 parts, dried plum 45-55 parts, Coptis chinensis 8-12 parts, hawthorn 35-45 parts, magnesium stearate 5-7 parts, sucrose 28-32 parts; This invention uses low-temperature dynamic extraction technology to replace the traditional high-temperature decoction process, effectively reducing the decomposition loss of heat-sensitive active ingredients such as tanshinone IIA and ursolic acid, and improving the bioavailability of the drug. It also uses membrane concentration and spray drying technology to replace the traditional atmospheric pressure concentration and oven drying process, shortening the production cycle, reducing energy consumption, and avoiding the degradation of active ingredients caused by prolonged heating of materials.

The invention relates to the technical field of traditional Chinese medicine compositions and preparations, in particular to a traditional Chinese medicine composition for treating liver depression and spleen deficiency type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from codonopsis pilosula, rhizoma atractylodis macrocephalae stir-fried with bran, radix bupleuri, stir-fried radix paeoniae alba, pericarpium citri reticulatae, fructus aurantii stir-fried with bran, ginger processed pinellia, radix salviae miltiorrhizae, medicated leaven, stir-fried endothelium corneum gigeriae galli and fingered citron according to The traditional Chinese medicine composition is based on the theory of inhibiting wood and supporting soil in traditional Chinese medicine, and all the components have a synergistic effect and have the effects of soothing the liver, relieving depression, strengthening the spleen and harmonizing the stomach. Animal experiments prove that the traditional Chinese medicine composition provided by the invention can significantly improve the gastric emptying rate and the small intestine propulsion rate of a chronic gastritis model, and can down-regulate the gene expression of gastric mucosa intestinal metaplasia related markers CDX2 and MUC2.

This invention provides a deep learning-based method for fine-tuning the general representation of gastritis pathological images. The method includes: obtaining a pathological feature extraction network based on a first pathological image and a training strategy; obtaining a pathological evolution manifold based on the pathological feature extraction network and training a lesion reversal simulator to obtain a pathological evolution base model; obtaining a downstream task classification head and a second pathological image; freezing the parameters of the pathological evolution base model and inserting cue vectors into the pathological feature extraction network; training the cue vectors and the downstream task classification head using the second pathological image to obtain a fine-tuned model; inputting a third pathological image into the fine-tuned model, obtaining analysis results, and using the pathological evolution base model to generate lesion deviation data for the third pathological image. This invention achieves efficient adaptation to downstream tasks under small sample conditions while not forgetting the internalized disease continuity evolution patterns of the model.

The composition is prepared from the following raw materials: 50 to 70 parts of rhizoma dioscoreae, 25 to 35 parts of radix paeoniae alba, 25 to 35 parts of rhizoma atractylodis, 10 to 20 parts of rhizoma zingiberis, 10 to 20 parts of radix cynanchi bungei and 10 to 20 parts of raw fructus crataegi. The preparation method comprises the following steps: 1, raw material pretreatment; 2, superfine grinding; 3, mixing process; and 4, forming process. The traditional Chinese medicine composition has the advantages that the dual effects of diminishing inflammation, sterilizing and repairing tissues are achieved through a specific proportion and a preparation process, the traditional Chinese medicine composition is suitable for treating and preventing chronic gastritis and gastric ulcer diseases, and accurate component protection is achieved through a three-section gradient drying process; differential superfine grinding and plasma activation have a synergistic effect; the double-layer sustained-release pill design realizes accurate matching; and the safety of microorganisms is guaranteed through multi-mode sterilization.

The present invention provides a tegoprazan sugar acid salt and a preparation method therefor, the salt being pharmaceutically usable for gastroesophageal disease, gastroesophageal reflux disease, gastritis, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, non-erosive reflux disease (NERD) and the like. The tegoprazan sugar acid salt of the present invention has excellent water solubility and stability of tegoprazan, and thus can be particularly useful as a pharmaceutical injection preparation.

The present invention relates to an antisense oligonucleotide targeting an interleukin 4 receptor and the use thereof. The antisense oligonucleotide (ASO) molecule has a length of 16-22 bases and is specifically paired with a specific region of a target gene (interleukin 4 receptor). The ASO is used for treating diseases associated with IL-4Rα, which includes, but is not limited to, asthma (including eosinophilic asthma), atopic dermatitis, eosinophilic esophagitis, sinusitis, nasal polyps, prurigo nodularis, urticaria, chronic obstructive pulmonary disease, bullous pemphigoid, pruritus, and gastritis.

The invention is suitable for the technical field of medicine, and provides a stomach medicine capsule and a preparation method thereof, the stomach medicine capsule is prepared from 20-30 parts of Chinese angelica, 7-11 parts of phoenix-tail fern, 15-19 parts of radix berberidis, 5-9 parts of radix aucklandiae, 2-4 parts of reed seed, 13-17 parts of sea snail and auxiliary materials; the preparation method comprises the steps of raw material pretreatment, ethanol reflux extraction, vacuum concentration, spray drying, mixing granulation, capsule filling and packaging. The traditional Chinese medicine raw materials in a specific proportion are screened, the synergistic effect of resisting inflammation and bacteria, regulating qi to relieve pain, nourishing blood and repairing, and relieving acid and protecting the stomach is achieved, and the problems that an existing stomach medicine is single in effect and large in side effect are solved; meanwhile, extraction and drying processes are optimized, the dissolution rate of effective components and the stability of the preparation are improved, and the traditional Chinese medicine composition is suitable for treating stomach diseases such as acute and chronic gastritis, gastric ulcer and hyperacidity, high in safety and suitable for long-term administration.

The invention discloses lactobacillus reuteri CCFM1454, polysaccharide prepared from the lactobacillus reuteri CCFM1454 for relieving gastritis and application of the polysaccharide in synergism with rhizoma polygonati, and belongs to the technical field of microorganisms and medicines. According to the lactobacillus reuteri CCFM1454, the content of gastritis markers PGE2 and TFF3 can be remarkably reduced; the content of inflammatory factors is adjusted; the gastric mucosa is protected and inflammation is relieved by regulating and controlling key signal channels such as STAT3 and SOCS3. In addition, the compound polysaccharide extracted after the rhizoma polygonati polysaccharide is fermented by the lactobacillus reuteri CCFM1454 has a synergistic effect; active substances, such as saponin, flavone and the like, in rhizoma polygonati are converted through fermentation of lactobacillus reuteri CCFM1454, and the absorption rate and bioavailability of the rhizoma polygonati are improved. The strain and the fermentation product thereof have important potential in the development of products for relieving gastritis and repairing gastric mucosa, and can be widely applied to the fields of food, health care products, medicines and the like.

The invention relates to a traditional Chinese medicine preparation for treating gastritis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 40-50 parts of a traditional Chinese medicine composition, 10-15 parts of a sustained release agent, 25-32 parts of a filling agent and 3-8 parts of a flavoring agent, the slow release agent is modified carboxymethyl konjac glucomannan; the filling agent is cordyceps militaris polysaccharide and lactose; the flavoring agent is aspartame or sucralose. The sustained release agent is neohesperidin dihydrochalcone modified carboxymethyl konjac glucomannan, neohesperidin dihydrochalcone has the effect of inhibiting gastric acid secretion, and neohesperidin dihydrochalcone and the traditional Chinese medicine ingredient cuttlebone can synergistically play a role in preparing acid and jointly play a role in protecting gastric mucosa. Meanwhile, the cordyceps militaris polysaccharide has polysaccharide generality of thickening and stable film forming, and forms a compact network structure together with the modified carboxymethyl konjac glucomannan, and the obtained traditional Chinese medicine preparation has a good slow release effect.

This invention belongs to the technical field of organic small molecule fluorescent probes and provides a fluorescent probe for viscosity detection. In high-viscosity solutions, the probe exhibits strong fluorescence in the near-infrared region, with high sensitivity, a large Stokes shift, and a high signal-to-noise ratio. This probe can be used not only to detect viscosity changes within mitochondria in living cells but also to measure viscosity in situ gastritis, demonstrating significant advantages in biological analysis and detection.

The invention discloses substitutional tea with effects of preventing hypertension, hyperglycemia, hyperlipidemia and gastric cancer. The substitutional tea is prepared from the following raw materials in parts by mass: 0.8 to 1.2 parts of rhizoma zingiberis, 0.8 to 1.2 parts of poria cocos, 0.8 to 1.2 parts of cortex cinnamomi, 0.8 to 1.2 parts of pericarpium citri reticulatae, 0.3 to 0.7 part of liquorice root, 0.8 to 1.2 parts of rice, 0.8 to 1.2 parts of wheat, 0.08 to 0.12 part of radix ginseng and 0.08 to 0.12 part of folium perillae. The invention develops a tea substitute drink with a prevention effect aiming at the rejuvenation current situation of people with hypertension, hyperlipidemia, hyperglycemia and chronic gastritis. The tea substitute drink has the characteristics of being convenient to brew and convenient to produce, and is easy to use by consumers and easy to produce by manufacturers. The components are easy to absorb, and the prevention effect can be better achieved. Meanwhile, the product is clean and environment-friendly, the burden on the environment is reduced, and the cost performance is high. By adopting the concept of homology of medicine and food, the tea is suitable for people with hypertension, hyperlipidemia and chronic gastritis to drink daily and provides a new choice for preventing related diseases.

Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

Provided herein are formulations for use in enteral tube feeding, that contain one or more whole food-based ingredients, mineral nutrients, small molecules, and / or large molecules, the combination of which is effective to bind bile acids when administered to a subject in need thereof. The combination of crafted ingredients for tube feeding reduce symptoms of gastroesophageal reflux, vomiting, abdominal pain, irregular stooling (diarrhea or constipation) and to reduce organ damage including pneumonia, pharyngitis, aspiration, esophagitis, gastritis and enteritis.

A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVII).

The utility model relates to the technical field of medical instruments, and discloses a hot compress device for gastritis treatment, which comprises a hot compress bag, and a bag cover is arranged at the top of the hot compress bag. According to the hot compress device for gastritis treatment, a heated medicine bag is placed in a hot compress bag and worn on the stomach of a patient, local blood circulation is promoted in a hot compress mode, when the hot compress bag needs to be detached or replaced, a round plate is pressed to drive a sliding rod to move towards the interior of a second shell, and the hot compress bag is placed in the second shell; the movable plate drives the clamping blocks to be separated from the interiors of the clamping grooves, fixation between the first shell and the second shell is relieved, quick disassembly of the hot compress bag is achieved, patients needing to frequently use the hot compress device can be conveniently dealt with, the length of the bandage can be conveniently adjusted by arranging the grooves and the fixing rods, the requirements of patients of different body types and figures can be met, and the practicability is high. The hot compress device can be tightly attached to the body, and the treatment effect is improved.

This invention relates to an antisense oligonucleotide targeting the interleukin-4 receptor and its applications. The antisense oligonucleotide (ASO) molecule is 16-22 bases in length and specifically pairs with a specific region of the target gene (interleukin-4 receptor). The ASO is used to treat diseases related to IL-4Rα, including but not limited to asthma (including eosinophilic types), atopic dermatitis, eosinophilic esophagitis, sinusitis, nasal polyps, nodular prurigo, urticaria, COPD, bullous pemphigoid, pruritus, and gastritis.

The invention provides application of hippophae rhamnoides extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking, and belongs to the technical field of biological medicine. The invention provides application of a sea-buckthorn extract or a product containing the sea-buckthorn extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking. The sea-buckthorn extract comprises sea-buckthorn fruit oil, sea-buckthorn seed oil and / or sea-buckthorn fruit pulp. The organ injury comprises alcoholic fatty liver, gastric mucosa injury or duodenum mucosa injury. The hippophae rhamnoides fruit extract (hippophae rhamnoides fruit pulp, hippophae rhamnoides fruit oil and hippophae rhamnoides fruit seed oil) and the hippophae rhamnoides fruit and Chinese wolfberry fruit composite primary pulp provided by the invention have the effects of promoting the repair of gastric mucosa and duodenal mucosa and further enhancing the immunity of gastrointestinal tracts, and can effectively prevent and / or treat gastritis, alcoholic fatty liver and duodenal mucosa injury caused by drinking; the traditional Chinese medicine composition can replace traditional medicine treatment and has the advantages of small side effect, economy, practicability, suitability for long-term administration and good compliance.

The invention discloses a traditional Chinese medicine composition with stomach invigorating and liver soothing functions and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The composition is prepared from the following components in parts by weight: 30 to 70 parts of rhizoma atractylodis, 30 to 70 parts of rhizoma atractylodis macrocephalae, 30 to 50 parts of pericarpium citri reticulatae, 20 to 40 parts of fructus amomi rotundus, 30 to 70 parts of charred triplet, 30 to 70 parts of rhizoma pinellinae praeparata, 20 to 40 parts of radix aucklandiae, 30 to 50 parts of fructus aurantii, 30 to 70 parts of rhizoma cyperi, 30 to 70 parts of semen arecae, 20 to 40 parts of liquorice root, 30 to 70 parts of radix bupleuri, 30 to 70 parts of radix paeoniae rubra, 30 to 70 parts of radix paeoniae alba and 15 to 35 parts of radix curcumae. The traditional Chinese medicine composition has a relatively good treatment effect on chronic gastritis and chronic hepatitis, is relatively small in side effect and relatively small in influence on a human body, and can be used for treating diseases fundamentally according to causes of the diseases.

The invention discloses a traditional Chinese medicine composition for treating chronic gastritis, and relates to the technical field of traditional Chinese medicines. The main functional component of the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of parched white peony root, 10-20 parts of radix curcumae, 6-15 parts of radix aucklandiae, 3-9 parts of fructus amomi, 5-15 parts of fructus evodiae, 15-25 parts of cuttlebone, 10-20 parts of astragalus membranaceus, 10-20 parts of codonopsis pilosula, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of pinellia ternate, 15-25 parts of poria cocos, 10-20 parts of roasted rhizoma atractylodis macrocephalae, 10-20 parts of cassia twig and 3-9 parts of honey-fried licorice root. The compatibility of the traditional Chinese medicine composition conforms to the principle of'monarch, minister, assistant and guide 'of traditional Chinese medicines, and all the medicines are synergistic to strengthen the spleen, treat root causes, regulate qi to alleviate pain and simultaneously regulate the liver and the spleen; the effects of reducing phlegm and dampness, harmonizing the stomach, dispelling cold and treating both symptoms and root causes are achieved. The traditional Chinese medicine is high in clinical gastritis patient treatment efficiency, safe and free of side effects.

The present invention belongs to the field of biopharmaceutical technology and specifically relates to a notoginsenoside Fe composition and its use in preparing PTGS2 protein inhibitors and drugs for preventing and treating PTGS2 diseases. The notoginsenoside Fe composition provided by the present invention is composed of notoginsenoside Fe, ginsenoside Rg5, ginsenoside Rk1, quercetin, and eriodictyol. The present invention is the first to discover a novel PTGS2 inhibitor, notoginsenoside Fe, and prepare it into a notoginsenoside Fe composition, providing a new solution for the research and development of drugs for preventing and treating PTGS2-related diseases. The notoginsenoside Fe composition provided by the present invention can reduce the levels of inflammatory factors in mice in colitis, gastritis, and arthritis models, improve colon length, and alleviate foot swelling.

The invention provides a medicine containing hederagenin and application of the medicine in regulating and controlling lysozyme to block gastritis-cancer transformation, the interaction relation between hederagenin and a key target spot is preliminarily determined by combining the key target spot LYZ of gastric inflammation-cancer screened by early-stage bioinformatics and applying a molecular docking technology, and then verification is performed by applying in-vivo and in-vitro experiments. Results of research discover that the common component hederagenin of astragalus membranaceus-curcuma zedoary and the key target LYZ of the gastric inflammation-cancer have an interaction relationship, and in-vivo and in-vitro experiments prove that the hederagenin can regulate and control the key target LYZ of the gastric inflammation-cancer, so that a new foundation is laid for further screening of core medicine components and optimization of traditional Chinese medicine formulas. The research and development of effective drugs for preventing and treating early gastric cancer have important significance.

The invention discloses a traditional Chinese medicine composition for treating intestinal tract diseases, which is prepared from the following traditional Chinese medicines in parts by weight: 8-15 parts of selfheal, 20-40 parts of nacre mother of pearl, 5-10 parts of radix bupleuri, 3-8 parts of fried fructus aurantii, 3-8 parts of rhizoma cyperi, 6-12 parts of inula flower and 5-9 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition can be used for pertinently treating liver and gall stagnated heat, stomach qi reversal type bile reflux gastritis or gastroesophageal reflux disease, has the specific treatment effects of relieving inflammation, inhibiting local tissue angiogenesis and preventing precancerous lesions and / or canceration, and has good clinical significance.

The application discloses a sulfonamide compound, a preparation method and application thereof. The compound can selectively antagonize a human and mouse NOD1 signal path, can inhibit secretion of inflammatory cytokines, and can be used for treating inflammatory diseases, in particular, gastritis caused by helicobacter pylori infection.