125 results about "Organ damage" patented technology

The invention discloses a sepsis patient organ function damage early warning judgment method based on machine learning, and the method comprises the steps: obtaining the multi-modal clinical data of a sepsis patient, including vital sign time sequence data, inspection data, treatment intervention data and static patient basic information; after data standardization processing, organ function associated features are extracted through a multi-scale feature fusion strategy, and an organ-level feature set is constructed; the method comprises the following steps of: obtaining a multi-organ collaborative early warning model, inputting the multi-organ collaborative early warning model into a pre-trained multi-organ collaborative early warning model, respectively constructing an inter-organ compensatory relation map by double branches of the model, quantifying organ injury risk contribution degree, and outputting a multi-organ functional injury risk matrix by combining with attention mechanism weighted fusion; and generating an early warning result based on the risk matrix and the organ specificity early warning threshold, including the injury risk level of each organ and the dominant risk key feature identifier, monitoring data update in real time, and dynamically adjusting the interval to update the early warning result. According to the invention, the limitation of traditional single-source data and single-organ early warning is broken through, and the early warning accuracy and real-time performance are improved.

The invention discloses a preparation method of a cochlear organ chip integrated with a blood labyrinth barrier, and belongs to the field of biomedical engineering. The preparation method of the simulated blood labyrinth barrier comprises the following steps: constructing an endothelial cell culture cavity and a pericyte culture cavity, and separating the endothelial cell culture cavity and the pericyte culture cavity through a simulated basement membrane; and respectively inoculating percutaneous cells and endothelial cells into a percutaneous cell culture cavity and an endothelial cell culture cavity, and culturing to obtain the simulated blood lost barrier. The chip can effectively simulate the structure and the function of the BLB, and the barrier integrity of the BLB is evaluated through TEER (trans-epithelial electrical resistance) measurement and an apparent permeability coefficient. The invention also relates to application of the chip in NIHL drug screening, in particular to drug evaluation for oxidative stress induced inner ear organ injury. Through the platform, the protection effect of the candidate drugs on the TBHP-induced oxidative stress injury of the inner ear organs can be evaluated, and a new tool and thought are provided for developing novel NIHL treatment drugs.

The invention relates to an application of a bioactive peptide YPFPGPIH derived from bovine casein in the aspect of anti-inflammation or immunoregulation. The peptide can be combined with TLR2 and TLR4 to inhibit the activation of NF-kappa B and MAPK signal channels, so that the levels of inflammatory factors such as IL-1beta, TNF-alpha and NO are remarkably reduced, the expression of IL-10 is up-regulated, and inflammation balance regulation is realized; the body inflammatory response is improved, and the immune organ injury is recovered. The peptide can be used for preparing anti-inflammatory drugs, immunomodulatory functional foods and nutritional supplements, and has good safety and application prospects.

The invention relates to the technical field of clinical decision support and medical data intelligent analysis, in particular to a critical patient individualized liquid resuscitation decision support system, which is characterized in that a data acquisition unit acquires pulse pressure variation waveform and multi-dimensional physiological data of each stroke volume; a volume benefit analysis channel of the dynamic decision-making unit segments a respiratory cycle, extracts pulse pressure fluctuation characteristics, outputs a per-stroke volume increase probability value through a machine learning classifier, an organ injury early warning channel calculates a blood lactic acid and creatinine clearance rate change rate, and generates an acute kidney injury risk sign in combination with inferior vena cava image verification; the execution control unit sends an infusion control or limit instruction according to the combined state; and the feedback optimization unit adjusts the weight of the model according to the actual value of blood lactic acid removal, and recalculates the probability value, so that individualized precise resuscitation, balance capacity benefit and organ protection are realized, and the treatment safety and effectiveness are improved.

The invention discloses a curcumin nanocrystal preparation as well as a preparation method and application thereof. The invention relates to a curcumin nanocrystal composition which is prepared by drying and curing a curcumin nanocrystal suspension to a blank pellet core, the curcumin nanocrystal suspension contains 20-35% of curcumin nanocrystals, 1-10% of a three-dimensional protective agent and 1-10% of a charge protective agent, and the average particle size of the curcumin nanocrystals is 200-320 nm. The curcumin nanocrystal composition prepared by the invention can effectively prevent and treat heat stroke and complications thereof, remarkably improve heat tolerance, prolong survival time, reduce the level of inflammatory factors in blood, protect intestinal epithelial cells and intestinal barrier functions, reduce damage caused by heat stroke, prevent and treat body and organ damage caused by heat stroke, and improve the curative effect of the curcumin nanocrystal composition. The preparation has the advantages of being high in drug loading capacity, good in stability, high in bioavailability, safe, effective, convenient to carry and the like.

This invention discloses an antigen and vaccine preparation based on dominant Brucella epitopes, and their application, belonging to the field of recombinant subunit vaccine technology. The antigen is composed of CTL epitopes, HTL epitopes, and B-cell epitopes tandemly, and its amino acid sequence is shown in SEQ ID NO.1. Based on screened dominant CTL epitopes, HTL epitopes, and B-cell epitopes of the Omp25 and Omp31 outer membrane proteins, this invention constructs a novel antigen fusion polypeptide. The vaccine prepared based on this polypeptide effectively activates a significant dual immune response, enhancing cellular immunity while inducing the body to produce high levels of specific antibodies. It also provides good protection against organ damage caused by bacterial infection, offering better immune response and protective efficacy against Brucella, laying the foundation for the development of Brucella recombinant subunit vaccines.

The present invention relates to methods of producing hypoimmunogenic functional macrophages, and cell compositions comprising the same. The hypoimmunogenic functional macrophages may be polarised or unpolarised. Such cells may be useful in the treatment of diseases, e.g. inflammatory organ damage. The therapy that may be achieved by hypoimmunogenic functional macrophages is universal, and the cells do not require matching from donor to recipient. This broadens the application of cell-based therapies, in particular in patients with chronic liver fibrosis.

The application provides a preparation method of high-selenium compound powder for postoperative and radiotherapy rehabilitation immune repair, and belongs to the technical field of functional food or special medical use formula food processing technology.The application realizes sufficient wall breaking by respectively pre-wetting and low-temperature complex enzymolysis of hard plant wall and fungal wall raw materials, and then prevents active loss by using endogenous substances of the raw materials for in-situ anchoring without adding, after drying and crushing, adding postbiotic powder, active peptide, whey protein, yeast beta-glucan, EGCG and other heat-sensitive components into low-temperature sterile dry mixing, while maximizing the release of organic selenium and immune active substances, the heat-sensitive functional components are completely protected from degradation and inactivation, and finally the technical target of sufficient wall breaking, complete activity and stable immune repair effect is achieved.The product prepared by the application can improve the immune organ damage and immune homeostasis imbalance caused by radiotherapy, and is suitable for the immune repair of postoperative and radiotherapy rehabilitation population.

The invention is suitable for the technical field of biology, and provides an L-NAME induced trophoblast organ injury model and a construction method and application thereof, and the construction method of the trophoblast organ injury model comprises the following steps: constructing a trophoblast organ by using human villus tissue; the method comprises the following steps: carrying out culture and passage treatment on a trophoblast organ, and then adding L-NAME with the final concentration of 15-60mM to carry out induced injury, so as to obtain the trophoblast organ injury model. The basic model used in the invention is a trophoblast-like organ which can be subcultured for a long time, so that the problems of difficult acquisition of placenta samples and ethics limitation in the clinical early stage are reduced. Meanwhile, L-NAME is used for performing drug-induced injury, a trophoblast organ injury model for simulating the placental pathological state of preeclampsia can be constructed, and compared with traditional hypoxia-induced injury, the method is more convenient, and the limitation of instruments and equipment is reduced.

The invention relates to application of serum mucoid or Tax1 binding protein 1 in preparation of a medicine for treating medicine-induced liver injury or organ ischemia-reperfusion injury. Experiments prove that by using an adeno-associated virus (AAV) carrying an Orm2 gene, ORM2 recombinant protein or knocking down a TAX1BP1 gene, liver injury and liver failure, ischemia reperfusion injury of the liver, ischemia reperfusion injury of the kidney and ischemia reperfusion induction of intestines induced by APAP treatment can be effectively relieved, and the application has the advantages that the liver injury and liver failure, the ischemia reperfusion injury of the kidney and the ischemia reperfusion induction of the intestine can be effectively relieved; and a new target spot and a new treatment method are provided for treating the ferroptosis-related organ injury.

The invention discloses an interpretable machine learning method for predicting multi-organ injuries of diquat poisoning patients, and the method comprises the steps: constructing and verifying a prediction system of eight kinds of organ injuries through a clinical database; toxic encephalopathy, myocardial injury, acute kidney injury, circulatory failure, skeletal muscle injury, liver injury, lung injury and gastrointestinal tract injury are covered. According to the method, early-stage efficient prediction of multi-organ injury is achieved, deep insight is provided for potential biological mechanisms of organ injury, clinical formulation of individualized intervention strategies is facilitated, the prognosis management level of diquat poisoning patients is expected to be remarkably improved, and the incidence rate and case fatality rate of multi-organ failure are reduced. According to the technical scheme, high prediction precision is kept, meanwhile, balance of interpretability, stability and clinical applicability of the model is achieved, a reliable auxiliary diagnosis tool is provided for organ injury risk assessment of acute poisoning patients, and the method has important clinical application value and wide market prospects.

The application discloses a positioning method of uterine cardinal ligament and sacral ligament and a pelvic floor finite element evolution model construction method, and belongs to the field of two-dimensional digital modeling and biomechanics research. According to the pelvic floor anatomy structure, the starting point and the ending point of the cardinal ligament and the sacral ligament in the two-dimensional finite element model are determined, and a distributed nonlinear hyperelastic spring group is proposed to simulate the suspension mechanical properties of the cardinal ligament and the sacral ligament. An organ tissue proportional damage simulation method and a proportional damage expression are proposed, the nonlinear material stress-strain curve of the pelvic floor organ tissue is multiplied by a proportional damage factor to simulate the mechanical properties of the pelvic floor organ damage. A concentrated load application method and a concentrated force-displacement expression of the initial shape feature are proposed to simulate the initial genital cleft and the uterine-vaginal angle. The evolution model can intuitively show the mechanical changes and shape feature change trends of the pelvic floor from the initial injury to the severe prolapse, and provides a basis for the reconstruction surgery design of the pelvic organ prolapse.

This invention relates to the field of biomedical technology and discloses an amphiphilic nicotinamide adenine dinucleotide (NAD) + Couplings, nanomicelles and their applications. Amphiphilic NAD+ + Couplings have the following general structural formula: ; where NAD + R is a hydrophilic group, R is a hydrophobic antioxidant group, and phenylboronic acid derivative is the linking bond; R is selected from free radical scavengers, small molecule organoselenic compounds that mimic the function of glutathione peroxidase 4, iron chelating agents, 7-dehydrocholesterol, royal jelly acid, α-lipoic acid, oleic acid, or derivatives of the above molecules. In this invention, NAD... + Conjugates and their self-assembled nanomicelles possess functions such as promoting DNA repair, maintaining cellular homeostasis, and delaying aging. Simultaneously, nanomicelles can inhibit inflammation and oxidative stress, and can physically encapsulate hydrophobic active drugs, showing broad application prospects in inflammatory diseases, age-related diseases, organ damage, and the prevention and treatment of toxic side effects from chemotherapy drugs.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for improving alcohol tolerance of a user and relieving uncomfortable symptoms of the user after drinking. Compared with modern medical treatment, the traditional Chinese medicine compound is started from multiple mechanisms of relieving alcoholism, protecting liver and stomach and dredging collaterals and blood stasis, whole-course intervention from acute symptom control to organ injury repair is achieved, and the traditional Chinese medicine compound is more suitable for the complex pathogenesis of alcoholism multi-system injury. According to the formula, an effective traditional Chinese medicine scheme is provided for drunkenness patients according to the core treatment principle of separately eliminating and draining, and clearing away heat and toxic materials. The composition can significantly improve the alcohol tolerance of a user, alleviate the vomiting symptom of the user after drinking, and improve the discomfort symptom of the user after sobering up. The traditional Chinese medicine composition is a pure traditional Chinese medicine formula, is safe and has no toxic or side effect.

Provided is a pharmaceutical composition and application thereof, specifically, said pharmaceutical composition comprises: salvianolic acid B as a first active ingredient; and ginsenoside Rg1 as a second active ingredient, and the weight ratio of the first active ingredient to the second active ingredient being 5:(1-4.5). The pharmaceutical composition has a better active-ingredient proportion than the prior art, has a better therapeutic efficacy in preventing and / or treating ischemic diseases, and ischemia-reperfusion tissue or organ damage, and can be used for treating ischemia and / or ischemia-reperfusion damage of different tissues and organs.

The invention belongs to the technical field of biological medicine, and provides a human umbilical cord mesenchymal stem cell preparation and application thereof, the preparation comprises human umbilical cord mesenchymal stem cells, ginsenoside Rg3 and a medicinal carrier; the medicinal carrier is a phosphate buffer solution; according to the application, 1 * 10 < 6 > HUCMSCs pretreated by Rg3 are subjected to caudal vein injection on a T2DM mouse model induced by high fat diet combined with STZ, the curative effect and mechanism are verified by combining OGTT, IPITT, serum biochemical detection, HE / PAS tissue staining, q-PCR and other technologies, and finally the purposes of improving glycometabolism of the T2DM mouse, repairing liver / kidney / pancreas target organ injuries, protecting pancreas islet beta cell functions, reducing pancreas islet beta cell functions, reducing pancreas islet beta cell functions, reducing pancreas islet beta cell functions, reducing pancreas islet beta cell functions and the like are achieved. And a theoretical basis is provided for accurate intervention of T2DM by activating an IGF-1R / PI3K-AKT signal channel and regulating and controlling the expression of a glycometabolism-related gene.

The invention discloses screening of transcriptome biomarkers responsive to tanshinone IIA and application of the transcriptome biomarkers in sepsis diagnosis and treatment kits. Tanshinone IIA (TSA) inhibits an SAMSN1 gene in a targeted manner by up-regulating expression of mmu-miR-1896, so that an NRF2 / KEAP1 antioxidant pathway is activated, and GSDMD-mediated pyroptosis is inhibited, thereby reducing multi-organ injury. 10-20 mg / kg of TSA can significantly improve the alveolar structure of the LPS model and reduce inflammatory factors. A kit which is developed on the basis of the mechanism and is used for detecting the expression levels of mmu-miR-1896, SAMSN1 and NRF2-Kea1-GSDMD can be used for evaluating the curative effect.

Provided herein are formulations for use in enteral tube feeding, that contain one or more whole food-based ingredients, mineral nutrients, small molecules, and / or large molecules, the combination of which is effective to bind bile acids when administered to a subject in need thereof. The combination of crafted ingredients for tube feeding reduce symptoms of gastroesophageal reflux, vomiting, abdominal pain, irregular stooling (diarrhea or constipation) and to reduce organ damage including pneumonia, pharyngitis, aspiration, esophagitis, gastritis and enteritis.

The invention relates to an establishment method of a high-fat induced intestinal organ injury model and an injury intervention method for the model. The establishment method comprises the following steps: step A, preparation: preparing colon cells, PBMC cells and an organ-like culture chip for later use; step B, colon barrier construction: inoculating colon cells to the surface of a barrier membrane on the lower side of a culture chip by using an organoid culture chip to obtain a colon barrier model; step C, constructing a co-culture model, and inoculating PBMC cells to the basal side of the colon barrier on the basis of the colon barrier to obtain a human colon barrier-PBMC co-culture model; d, constructing a damage model, and performing damage treatment on the co-culture model by using a treating fluid to obtain the damage model; according to the invention, the barrier function organ-like chip is used, a human intestinal cell-PBMC co-culture model is formed by utilizing human intestinal organs and PBMC cells, and OXLDL / palmitic acid can play a role in an injured intestinal organ barrier model and form a high-fat induced intestinal organ injury model through the prepared injury treating fluid.

The invention provides application of hippophae rhamnoides extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking, and belongs to the technical field of biological medicine. The invention provides application of a sea-buckthorn extract or a product containing the sea-buckthorn extract in preparation of a product for dispelling the effects of alcohol or preventing and treating visceral organ injury caused by drinking. The sea-buckthorn extract comprises sea-buckthorn fruit oil, sea-buckthorn seed oil and / or sea-buckthorn fruit pulp. The organ injury comprises alcoholic fatty liver, gastric mucosa injury or duodenum mucosa injury. The hippophae rhamnoides fruit extract (hippophae rhamnoides fruit pulp, hippophae rhamnoides fruit oil and hippophae rhamnoides fruit seed oil) and the hippophae rhamnoides fruit and Chinese wolfberry fruit composite primary pulp provided by the invention have the effects of promoting the repair of gastric mucosa and duodenal mucosa and further enhancing the immunity of gastrointestinal tracts, and can effectively prevent and / or treat gastritis, alcoholic fatty liver and duodenal mucosa injury caused by drinking; the traditional Chinese medicine composition can replace traditional medicine treatment and has the advantages of small side effect, economy, practicability, suitability for long-term administration and good compliance.

The application discloses a bat moth lepidoptera cordyceps strain and application thereof in preparation of anti-neutron radiation medicines. Samsoniella hepiali The strain is the bat moth lepidoptera cordyceps strain P969 (Pleurotus spodoleucus), which is preserved in the China Center for Type Culture Collection and has a preservation number of CCTCC NO: M 20251172 and a preservation date of May 26, 2025. Mycelium extracts of the strain can protect biological tissues against neutron radiation and repair organ damage caused by neutron radiation, so that the strain has a wide development space and a good development and application prospect.

The invention provides application of EMD638683 and a compound thereof as a therapeutic target to preparation of a medicine for treating gastric cancer, relates to the technical field of biomedicine, and is technically characterized by providing application of EMD638683 (R-Form) as a therapeutic target to preparation of a medicine for treating gastric cancer. According to the application, a specific verification test proves that EMD638683 (R-Form) is targeted to an N40 glycosylation site of LT beta R, a TRIM28 / PCBP2 / SARM1 pathway is specifically blocked, and the off-target toxicity is low. After the cRGD modified liposome is delivered, the tumor specific enrichment can be realized, the bioavailability is improved, the damage to normal organs is reduced, and the safety is good. The medicine can effectively reverse gastric cancer radiotherapy resistance, is adaptive to radiotherapy non-responders with high LT betaR expression, assists in precise stratified treatment, and improves the survival rate of patients. A traditional DNA repair related mechanism is broken through, the sensitization effect is achieved by regulating and controlling a pyroptosis pathway, and a brand new direction is provided for research and development of gastric cancer radiotherapy sensitization drugs.

The invention relates to the technical field of data acquisition, in particular to a data acquisition application device of a sepsis organ injury risk time sequence analysis model, which comprises a base, a seat, armrests and the like, the seat is fixedly mounted on the base, the armrests are arranged on two sides of the seat, and the data acquisition application device further comprises a respiration data acquisition component, a urine collection component and a heartbeat detection component. A urine collecting assembly used for collecting data of a kidney system is installed on the base, and a respiration data collecting assembly used for collecting data of a respiratory system and a heartbeat detecting assembly used for collecting data of a cardiovascular system are installed on the seat. The breathing data acquisition assembly, the urine collection assembly and the heartbeat detection assembly are integrated on the seat, so that main signs of a respiratory system, a kidney system and a cardiovascular system of a patient can be monitored and sampled when the patient adopts a sitting posture; and thus, the purpose of conveniently collecting data to establish a corresponding organ injury risk time sequence analysis model is achieved.

The invention discloses a carp scale polypeptide as well as a preparation method and application thereof. The amino acid sequences of polypeptides contained in the carp scale polypeptide are respectively as follows: QPGSPGPAGPAGARGQQ, PGAPGA, AGPAGAAGPAGN, QPAARGPGPSGPGPKGN, QPRRGPGPAGARGADGN, TSFGRDRTH, AGPAGRHL, KYAGG, LYAN and PGPAGASGPAGRGGHL. The invention further discloses a preparation method of the carp scale polypeptide. The carp scale polypeptide has anti-inflammatory activity, can reduce generation of proinflammatory factors in vivo and relieve organ injury, and has a certain protective effect on sepsis.

The application belongs to the technical field of biological medicine, and relates to a mussel peptide and a preparation method and application thereof. The mussel peptide comprises one or more of the following peptide segments: (1) Ile-Leu-Thr-Glu-Arg (2) Leu-Asp-Leu-Ala-Gly-Arg (3) Val-Thr-Ile-Met-Pro-Lys (4) Met-Gln-Ile-Phe-Val-Lys (5) Leu-Phe-Asp-Ala-Val-Ile-Arg. The mussel peptide is prepared by adopting a complex enzyme-membrane separation-dextran gel column chromatography purification coupling technology. The peptide not only has the effect of relieving spontaneous hypertension, but also has the effect of improving various target organ damages caused by spontaneous hypertension. The application provides the possibility of application of the mussel peptide in improving various target organ damages caused by spontaneous hypertension or other diseases.

The utility model relates to bulletproof apron technical field, concretely refers to a multifunctional bulletproof apron. Including front apron and back apron, the front apron includes tactical waist seal, and the both sides of tactical waist seal all have elastic waistband, and the top side of tactical waist seal has two quick -release insert buckles no. 1, and the bottom side of tactical waist seal has two pieces of side leg guard, the chaff guard, two pieces of front leg guard, the back apron includes the protective outer seat pad and the protective inner seat pad of upper and lower layer structure, and the protective inner seat pad has adjustable waistband, and the both ends of adjustable waistband are connected through quick -release insert buckle no. 2, the bulletproof apron is composed of inner fabric layer, outer fabric layer and protective layer, and inner fabric layer and outer fabric layer suture and wrap protective layer. The utility model provides a kind of multifunctional bulletproof apron with bulletproof, anti-fragment, anti-knife cone, high temperature resistance, infrared radiation and comfort, can comprehensively protect the key parts below waist, reduce reproductive organ damage, and do not affect tactical action, improve combat survivability.

The invention provides a composition for dispelling effects of alcohol and protecting liver and stomach, a preparation method of the composition and a product for dispelling effects of alcohol and protecting liver and stomach, belongs to the technical field of products for dispelling effects of alcohol, and aims to solve the problem that existing products for dispelling effects of alcohol are difficult to provide comprehensive and synergistic protection for multiple organ injuries caused by alcohol. The composition for dispelling effects of alcohol and protecting liver and stomach comprises: 10-30 parts of acid-soluble chitosan; 30 to 50 parts of carboxymethyl chitosan; 20-30 parts of wrapping taurine; and 5-15 parts of sea urchin powder. The composition for dispelling effects of alcohol and protecting liver and stomach can realize multi-mechanism synergistic protection.

The invention belongs to the technical field of medicines, and discloses an application of rhynchophylline in preparation of a medicine for reversing organ injuries, and the organ injuries are heart injuries and liver injuries induced by ketamine. According to the invention, ketamine is used for inducing miRNA expression of mouse heart, liver and PBMCs to be up-regulated / down-regulated, and then rhynchophylline is used for intervention, and the miRNA expression is correspondingly changed (down-regulated / up-regulated), so that a gene intervention regulation mechanism of ketamine addiction to occurrence and development of changes of heart, liver and peripheral blood immune functions and the like can be further known; moreover, the rhynchophylline can act on miRNA change caused by ketamine addiction in a multi-target manner, and heart injury, liver injury and PBMCs (peripheral blood mononuclear cells) related immunologic function abnormality caused by ketamine abuse can be effectively intervened.

Compounds defined by Formula 4 are used as cyclophilin inhibitors for the prevention or treatment of diseases or disorders, in particular diseases or conditions associated with cellular injury or cell death, such as organ injury or organ failure, which can be caused by a number of different reasons, such as ischemia or ischemia reperfusion injury, toxins, infection or mechanical trauma.

The present invention provides compounds and compositions for inhibiting complement-mediated damage to cells, tissues, or organs. [Solution] The present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. Furthermore, it provides methods for using cell-reactive compstatin analogs, for example, to inhibit complement-mediated damage to cells, tissues, or organs, for example, to treat complement-mediated disorders. Furthermore, it provides long-acting compstatin analogs and compositions comprising long-acting compstatin analogs. Furthermore, it provides methods for using long-acting compstatin analogs, for example, to inhibit complement-mediated damage to cells, tissues, or organs, for example, to treat complement-mediated disorders. Furthermore, it provides targeted compstatin analogs and compositions comprising targeted compstatin analogs.