28 results about "Tissue ischemia" patented technology

The utility model relates to a self-adaptive pressure tourniquet which comprises a fixing band body, the unfolding face of the fixing band body is in a sector shape with the upper portion wide and the lower portion narrow, rope drawing grooves are formed in the upper end and the lower end of the fixing band body along the edges, corresponding drawing ropes are arranged in the rope drawing grooves, and the other ends of the drawing ropes are movably connected with contraction blocks. The upper end of the side, attached to the skin, of the fixing band body is fixedly connected with a first air bag, the lower end of the side, attached to the skin, of the fixing band body is fixedly connected with a second air bag, and the fan-shaped tourniquet with the wide upper portion and the narrow lower portion can better adapt to differences of limb shapes and sizes of different patients; according to the tourniquet, the fixing band body is arranged, the attaching degree of the fixing band body and the limb is further adjusted through the drawing rope, the tourniquet can be tightly attached to the limb parts with different thicknesses, the multiple air bags can distribute pressure more evenly, and the risk of tissue ischemia and even necrosis caused by uneven pressure is reduced.

The utility model relates to an intraoperative intermittent inflatable anti-pressure eyeshade, the intraoperative intermittent inflatable anti-pressure eyeshade comprises an eyeshade main body, a first pipeline and a second pipeline, the first pipeline is arranged in the eyeshade main body, a plurality of support air bags are arranged on the first pipeline, the second pipeline is arranged in the eyeshade main body, the support air bags are arranged on the second pipeline, and the support air bags are arranged on the support air bags. A plurality of first supporting air bags are arranged on the first pipeline, a plurality of second supporting air bags are arranged on the second pipeline, and the first supporting air bags on the first pipeline and the second supporting air bags on the second pipeline are alternately arranged, fully distributed on the periphery of the eyeshade body and correspond to the peripheral positions of eye sockets. The first supporting air bag of the first pipeline and the second supporting air bag of the second pipeline can intermittently protrude out of the eyeshade main body during inflation so as to support skin tissues around eye sockets, so that pressure is prevented from being applied to the same part for a long time, and the risk of ischemia and hypoxia of the tissues around the eye sockets is reduced; the formation of pressure sores is prevented.

The utility model relates to the technical field of medical instruments, in particular to a catheter. The catheter comprises a catheter body, and a plurality of side holes and valves are arranged on the periphery of the far end of the catheter body. At least two valves are respectively arranged at each side hole of the catheter body; the pressure in the catheter body is larger than the pressure outside the catheter body, and the adjacent valves can abut against each other to seal the corresponding side holes. The pressure in the catheter body is smaller than the pressure outside the catheter body, and channels can be formed between the valves to open the side holes. According to the technical scheme, the problems that in the prior art, forward blood flow at the near end of the aorta is blocked due to the fact that the size of a duct tube is large, tissue ischemia of the blocked portion is caused, and operation risks are increased are solved.

This invention relates to the field of medical device technology and discloses a multifunctional auxiliary device for thyroid surgery, comprising: a base; a tension band; a binding block; a base component connected to the binding block, the base component including a fixed ring and a movable ring, the fixed ring being connected to the binding block, the movable ring being rotatably mounted on top of the fixed ring, and the movable ring being coaxial with the fixed ring; traction components, with several sets of traction components mounted on the movable ring; and a drive mechanism. By setting a rotatable movable ring and multiple sets of traction components, during surgery, the drive mechanism drives the movable ring to rotate intermittently in both directions, causing several rotating rods to intermittently change positions at the incision site, thereby continuously changing the stress points of the incision tissue. This allows tissues in different areas to take turns bearing the traction force and receiving blood perfusion, effectively avoiding local tissue ischemia, hypoxia, and plastic deformation caused by stress concentration in traditional traction devices, significantly protecting tissue activity, and promoting postoperative healing.

Sickle cell disease (SCD) is a single gene disorder characterized by mutant hemoglobin-S (HbS) and chronic intravascular haemolysis. Painful vaso-occlusive crises (VOC) are typical of SCD and often associated to a further rise in hemolysis. VOC is the clinically painful form of vaso-occlusion, that is due to the aggregation of red blood cells in the capillaries and venules. Such event is promoted or aggravated by adhesion of polymorphonuclear neutrophils (PMNs) to red blood cells and the endothelium leading to tissue ischemia, inflammation and imperfect repair. Repeated vaso-occlusion and PMNs interactions with the vascular endothelium are thought to promote microvascular injuries in SCD patients. The inventors tested the effect of pharmacological inhibition of TREM-1 with LR12 peptide in two experimental vaso-occlusive crisis models. Additional validation of TREM-1 involvement in vaso-occlusion was verified using mice with sickle cell disease and Trem-1 gene deficiency. In particular, the inventors showed that TREM-1 inhibition is particular suitable for limiting the severity of vaso-occlusions. The results obtained by the inventors also suggest that plasmatic concentration of sTREM-1 could be a reliable biomarker for predicting vaso-occlusions and / or SCD-associated organ dysfunction and end-organ damage.

The invention discloses application of palmitoleic acid in preparation of a medicine for protecting nerves and treating cerebral ischemia-reperfusion injury, and belongs to the field of biological medicine. Animal experiments prove the neuroprotective effect of palmitoleic acid on cerebral ischemia-reperfusion injury for the first time. By establishing a mouse cerebral ischemia reperfusion injury model, the palmitoleic acid is found to be capable of remarkably improving neurological impairment and reducing the volume and area of cerebral infarction, which indicates that the palmitoleic acid can be used for effectively limiting ischemic necrosis of brain tissues. According to the application, the research limitation that palmitoleic acid is traditionally applied to metabolic diseases is broken through, a brand new treatment strategy is provided for solving clinical ischemic stroke reperfusion injury, a solid foundation is laid for developing novel neuroprotective drugs, and important clinical application value and development prospects are shown in the aspect of improving prognosis of stroke patients.

A phenothiazine ferroptosis inhibitor, a preparation method therefor and an application thereof. Specifically provided is a compound represented by formula I, or a salt thereof, or a stereoisomer thereof. The synthesized phenothiazine compound has a good inhibitory effect on ferroptosis and has good drug safety. Moreover, the compound can be used to prepare a ferroptosis inhibitor, and can also be used to prepare a drug for treating diseases related to ferroptosis, such as neurodegenerative diseases, tumors, tissue ischemia reperfusion injury, stroke, cardiovascular diseases, renal failure, and diabetic complications.

A fixation device for the treatment of diabetic peripheral neuropathy, belonging to the field of fixation technology, aims to address the problem that prolonged pressure on the same location during long-term treatment can easily lead to pressure marks, ischemic injuries, or even pressure sores. The invention includes a bed frame with two placement plates fixedly installed on one side. A lifting seat is fixedly installed on the surface of each placement plate. Three moving parts are evenly distributed below the lifting seats. A driving component is fixedly installed on one side of the lifting seats. Three adjusting seats are slidably connected to the surfaces of the three moving parts. A first rolling pressure plate is fixedly installed at one end of the adjusting seat in the middle position, and a second rolling pressure plate is rotatably connected to one end of the adjusting seats on either side. This invention allows for switching between different pressure points, avoiding prolonged pressure on the same location and preventing the risk of local tissue ischemia and necrosis. Furthermore, it maintains the fixation of the lower leg while switching between different pressure points, improving the stability of the lower leg during treatment.

The utility model relates to a balloon catheter which comprises a catheter body, a balloon and a limiting layer, the balloon is arranged on the periphery of the catheter body in a sleeved mode and can expand or contract, and a through flow channel is formed between the balloon and the catheter body in the expanded state. The limiting layer comprises an outer limiting layer covering the outer side of the balloon, and the compliance of the outer limiting layer is smaller than that of the balloon. When the balloon is expanded, a through flow channel is formed between the balloon and the catheter, so that blood passes through the flow channel while the balloon is tightly attached to the wall of a blood vessel, ischemia or necrosis of far-end tissue is avoided, the balloon can be placed in the blood vessel for a longer time, and a better expansion effect is achieved; the limiting layer can limit the diameter of the balloon within a set range, the dog bone effect can be effectively prevented, and the treatment effect is good.

This invention relates to the field of intelligent hemostasis and discloses an intelligent tourniquet control method and system based on data analysis. The method includes continuously acquiring data on tourniquet tension displacement, contact surface pressure feedback, and limb pulse response, and performing dynamic synchronous correction according to the correspondence between pressure inflection points and pulsation attenuation nodes in each sensor signal. By comparing the offset relationship between the circumferential pressure change rate and distal micropulsation residue, a hidden pressure relief segment in the effective occlusion state is identified. After the contact instability map is expanded along the circumferential contact boundary of the tourniquet, environmental fluctuations and blood flow recovery characteristics are separated. When the dynamic force transmission distribution enters a continuous change phase, high-frequency fluctuation segments within the compression safety window are processed. The pressure replenishment rhythm and release interval of the drive component are adjusted with reference to the stable boundary migration trajectory. The hemostasis control result is output based on the hemostasis completion rate, tissue ischemia risk, and environmental interference level. This invention has the advantage of improving hemostasis stability in complex environments.

The present application relates to a kind of device for treating anal fistula, comprising: silk thread;Magnetic beads, spherical structure, the number of the magnetic beads is multiple, multiple the magnetic beads are connected on the silk thread;Blocking structure, fixedly connected in the middle of the silk thread, for blocking the inner mouth of the anal fistula.The device for treating anal fistula provided by the present application can be used instead of probe, and will not damage the tissue around fistula;Through the magnetism of magnetic beads, the magnetic beads in the inner mouth of anal fistula can be easily sucked out of the anus, without finger into anus blind find, easy to operate;After the device passes through fistula, the magnetic beads at both ends of silk thread are attracted to form closed loop structure, and the magnetic attraction between the magnetic beads generates continuous compression force on the tissue in closed loop, so that the tissue in closed loop is ischemic necrosis, and the reliability during use is improved, since silk thread is not easy to break;Blocking structure can reliably block the inner mouth of anal fistula, prevent dirt from entering fistula, and is beneficial to healing.

The invention discloses a tension adjusting system and method of an incision retractor, and relates to the technical field of medical instruments, the tension adjusting system comprises a flexible channel, a built-in ring is arranged at the far end of the flexible channel, and a fixed base is arranged at the near end of the flexible channel; the central tension adjusting system comprises a plurality of first adjusting belts, the first adjusting belts are embedded in the wall of the flexible channel and evenly distributed in the circumferential direction of the flexible channel, and the far ends of the first adjusting belts are fixedly connected with the far-end built-in ring. According to the invention, through dual mechanisms of manual central adjustment and automatic cooperative adjustment and in combination with a unique non-equilibrium compensation mode, precise, stable and adaptive control of the retraction force of the surgical incision is realized, so that the uniformity and stability of exposure of the surgical field are remarkably improved; and tissue ischemia injury caused by overlarge local pressure can be effectively avoided, and meanwhile, the operation convenience of a doctor and the safety of an operation process are enhanced.

The application belongs to the technical field of medical equipment, and particularly relates to a pressing hemostasis device for a cardiology department, which comprises a mounting box, wherein the mounting box is in a ring shape, a PLC controller is fixedly connected to the upper side wall of the mounting box, a micro power supply is connected to the inner wall of the mounting box, an internally-threaded cylinder is inserted into the mounting box, the internally-threaded cylinder is rotationally connected to the inner wall of the mounting box through a bearing, and a self-locking threaded rod is inserted into the internally-threaded cylinder in a threaded manner. Before the pressing hemostasis device is placed on a puncture point on the arm of a patient for pressing hemostasis, different pressures can be applied to the puncture point according to the thickness of the arm of the patient, so that the blood vessels are ensured to be closed under sufficient compression, and the blood vessels are also prevented from bearing excessive pressure, so that tissue ischemia, hypoxia, pain, numbness and other uncomfortable symptoms are caused.

The invention discloses a protective restraint strap, and relates to the field of protective restraint, the protective restraint strap comprises two sleeve straps, one side of each sleeve strap is provided with a fastening mechanism, each fastening mechanism comprises a flexible shell, and one side of each flexible shell is fixedly connected with one side of the adjacent sleeve strap; according to the protective restraint strap, the medical grade silica gel and breathable fiber mixed material is adopted, the self-adaptive air bag, the pressure sensor and the infrared multifunctional sensor are combined to form a closed-loop monitoring system, the pressure and blood flow state can be sensed in real time, the servo motor is automatically triggered to adjust the tightness degree when the pressure and blood flow state is abnormal, and tissue ischemia is avoided; one-key automatic tightening and accurate control are achieved through a servo motor, a tooth column and a clamping rack in the fastening mechanism, and the operation efficiency and the standardization level are improved; and the retaining ring mechanism is connected with an external anchor point by virtue of a rope belt, and is matched with a magnetic attraction and insertion structure of a magnet block and a clamping groove, so that the anti-struggling capability is enhanced, and comfortable, intelligent and safe multi-dimensional constraint is integrally realized.

This invention relates to the field of medical device technology and provides a balloon, comprising: a balloon body; and a traction wire adapted to the balloon body. The traction wire applies stress to at least a portion of the surface of the balloon body in its inflated state, causing at least one indentation to form on the surface of the balloon body connecting its proximal and distal sides. When the balloon body remains inflated, the indentation forms a channel allowing partial blood flow. The balloon provided by this invention can intermittently block or open bypass channels during surgery, avoiding complete blockage of blood flow during balloon expansion. This achieves the effect of occlusion without complete shut-off, reducing significant blood loss and preventing ischemia and necrosis of downstream tissues.

This invention provides a medical compression stocking, comprising: a stocking body and raised granules. One end of the stocking body has an open toe opening. The stocking body is worn from the patient's foot to below the knee, and includes an ankle pressure zone and a foot pressure zone. The ankle pressure zone provides a pressure range of 15–21 mmHg, and the ratio of the pressure provided by the foot pressure zone to that provided by the ankle pressure zone is 0.3–0.4. Multiple raised granules are spaced apart on the inner side of the stocking body. The highest point is below the knee and completely covers the foot, with only the toes exposed, making it easy to put on and take off, facilitating direct observation of nail bed blood circulation, and avoiding pressure relaxation caused by repeated removal of the stocking. The gradient pressure avoids excessive pressure on the toes, eliminating the risk of tissue ischemia. The raised granules provide continuous static pressure stimulation, which helps shorten the recovery time of postoperative bowel sounds and reduce abdominal distension. No active manipulation is required, making it particularly suitable for bedridden patients, thereby improving recovery outcomes.

The invention discloses an easy-to-knot suture line for surgical operation. The easy-to-knot suture line comprises a main line body, the two ends of the main wire body are provided with preset fracture parts, and the ends, away from the main wire body, of the preset fracture parts are provided with extension wire bodies. The diameter of the preset fracture part is smaller than that of the corresponding main line body and extension line body, and the joint is in arc transition; and an annular concave part is arranged at the middle end of the preset fracture part. By arranging the preset fracture part, the knotting force depending on subjective experience is converted into an objective physical threshold value; when the tensioning force reaches a preset safe effective value, the preset fracture part is fractured, force application is automatically stopped, and the risks of tissue avascular necrosis caused by too tight ligation or bleeding and cracking caused by too loose ligation are avoided.

The utility model belongs to the field of arm brackets, and particularly relates to an adjustable arm bracket for nursing, which comprises a bracket body, the bracket body comprises a first base, the top of the first base is fixedly connected with a first arm support, and the back side of the first base is provided with a second base; when the angle needs to be adjusted, a handle is pressed to drive a rotating column to rotate, the rotating column rotates to drive a lifting block to move, the lifting block moves to drive a clamping block to move until the clamping block moves out of a positioning groove, a first base is rotated at the moment, and after the angle is adjusted to a desired angle, the handle is loosened, and the clamping block is moved out of the positioning groove. The clamping blocks are clamped into the positioning grooves for positioning, the angle adjusting effect is achieved, and the problems that if the arms of the patient are in one posture for a long time, local blood circulation is blocked, blood supply of all parts of the arms is affected by unsmooth blood circulation, local tissue ischemia and hypoxia are caused, and then a series of uncomfortable symptoms are possibly caused are solved.

This invention relates to the field of aquatic life rescue technology, and discloses a rescue device for large aquatic organisms and its method of use. The large aquatic life rescue device provided by this invention features a flexible support surface and multiple interconnected inflatable chambers at the bottom, with a total buoyancy less than the fish's own weight. After the fish is placed, its own weight causes the flexible surface to passively collapse, adaptively forming an arc-shaped support surface that conforms to the three-dimensional contour of the abdomen, thus evenly distributing pressure and preventing tissue ischemia, necrosis, or damage to the mucus layer. The collapsed sidewalls can flexibly suppress displacement and movement of the fish during struggle, reducing stress response. By continuously adjusting the inflation volume, the same platform can accommodate large aquatic organisms of different weights and abdominal shapes, expanding the device's applicability.

The invention relates to the technical field of medical dressings, in particular to a medical dressing for pressing a puncture wound surface, which comprises a substrate layer, a dressing layer and a pressing component, the substrate layer is of a rectangular structure, the front end face of the substrate layer is of an adhesion structure, the pressing component is adhered to the middle of the front end face of the substrate layer, the dressing layer is further adhered to the front end face of the substrate layer, and the dressing layer is arranged on the front end face of the substrate layer. The pressing assembly is of a hemispherical structure, the front end of the pressing assembly protrudes out of the surface of the dressing layer, and the pressing assembly is used for pressing the puncture wound surface; the semi-spherical compression assembly capable of extending into the wound surface is adopted, the structure breaks through the limitation of a traditional plane dressing, pressure can be directly and accurately transmitted to a puncture channel, a main channel for body fluid seepage is effectively closed, through the design of the inflatable sealing cavity, the pressure of the outer silica gel hemisphere is adjusted according to the specific wound surface condition, and the sealing effect is good. The compression sufficiency is ensured, and the risk of insufficient compression or tissue ischemia caused by constant pressure is avoided.

The present application relates to the technical field of medical devices, and provides a balloon, which comprises a balloon body, a blood flow bypass pipeline arranged on the outer surface of the balloon body, a distal end opening of the blood flow bypass pipeline being located on the distal end side of the balloon body, and a proximal end opening being located on the proximal end side of the balloon body, and a flow adjusting mechanism, an execution part of the flow adjusting mechanism being adapted to the blood flow bypass pipeline, and an operation part of the flow adjusting mechanism being located outside the body, so that the execution part can be controlled by the operation part outside the body to block or open the blood flow bypass pipeline. The balloon provided by the present application can intermittently block or open the blood flow bypass pipeline during the operation process, avoid completely blocking the blood flow when the balloon is expanded, realize the effect of blocking without blocking, reduce the massive loss of blood, and prevent the ischemic necrosis of downstream tissues.

The invention relates to the field of anastomats, and discloses a gastrointestinal anastomotic stoma reinforcing anastomat with pressure feedback and a using method thereof.The gastrointestinal anastomotic stoma reinforcing anastomat comprises a grip used for supporting the whole device, and the inner wall of the grip is fixedly connected with an extension sleeve; the clamping assembly is arranged at the left end of the extension sleeve and used for clamping the wound and containing the nail box; the control assembly is arranged on the inner wall of the grip and used for controlling the clamping assembly to act; the brake assembly is arranged on the inner wall of the grip and used for braking the control assembly, the control assembly comprises a push rod, the push rod is slidably connected to the inner wall of the extension sleeve, a driving motor is installed on the inner wall of the grip, and an output shaft of the driving motor is in transmission connection with a threaded rod through a transmission box. Pressure data of different areas of the anastomotic stoma are collected in real time through the multiple sets of pressure sensors, the clamping force is automatically adjusted in combination with the control assembly, it is ensured that the average pressure is stabilized within the target range, and tissue ischemic necrosis caused by overpressure or infirm anastomosis caused by underpressure can be avoided.

The present application relates to the technical field of vaginal hemostatic tampon, in particular to a vaginal hemostatic tampon with compression cold compress and bleeding amount monitoring and application thereof, comprising a tampon body assembly, a compression capsule and an external control host; the tampon body assembly is composed of a cannula and a catheter inserted on the central shaft of the cannula; a plurality of backflow pipes are distributed on the circumference of an external section of the catheter for forming a circulating pipeline for circulating cooling medium; a plurality of flexible electrode groups are embedded on the outer wall of the compression capsule at equal intervals, and the external control host is used for providing and driving the cooling medium to circulate in the cannula; and the change of electrical impedance between the electrodes is detected. The double-layer circulating cooling structure composed of the cannula and the catheter is provided to realize cold compress hemostasis in the vagina; the bleeding state is sensed in real time by using the change of electrical impedance caused by the gathering of blood between the electrodes, and the bleeding speed grade is directly indicated to avoid tissue ischemia injury caused by blind excessive compression.

The application provides a multi-dimensional turning-over nursing pad for a pressure sore patient, and relates to the field of nursing pads, which comprises a main pad, wherein the main pad comprises a recess gradually formed from a long side of a main pad bearing surface to a middle line position, and a protrusion arranged on the recess at intervals; a rotating shaft is arranged at one end of the main pad, and a rotating end penetrates to a side edge of the main pad. The recess structure and the interval protrusion of the main pad bearing surface are combined with the air bag linkage mechanism of directional inflation in the cavity to realize the controlled jacking of the protrusion to form discrete support points, force the recess area to automatically separate from the patient's body surface to form an overhead air layer, and finally build a dynamic interval contact surface, so that the core effects of evenly dispersing body pressure, promoting air circulation and reducing the risk of tissue ischemia are achieved synchronously.

The utility model discloses a brachial artery hemostat with air bag, including the clamping plate, the tourniquet and the fixed band of connection on the clamping plate, the clamping plate has the arc shape of bionic human body arm appearance's arc support surface, is provided with air bag pad on the arc support surface, is provided with a plurality of through air holes on air bag pad, the tourniquet is movably connected on the clamping plate, is provided with silica gel pressure block on the tourniquet. The arc support surface of bionic human body arm appearance on the clamp can better support the shape of patient's arm, improve arm stress uniformity, the elastic soft air bag pad on the arc support surface can improve patient comfort, avoid rigid extrusion to patient's arm, a plurality of air holes on air bag pad can guarantee the air permeability of arm skin, the tourniquet of removal setting can adjust position according to the position of patient's wound, and silica gel pressure block can carry out flexible pressing to the wound on arm, avoid the tissue ischemia and injury caused by pressing too much while pressing the wound and carrying out compression hemostasis.

This invention provides a trauma hemostasis device suitable for lower limb stumps, belonging to the field of medical device technology. The device includes a tourniquet with an internal cavity. A pressure device connected to the cavity is fixedly installed at one end of the tourniquet. An air inlet is located at the connection between the pressure device and the cavity, and a one-way valve is installed inside the air inlet. In this design, a temperature sensing component can monitor the temperature of the stump in real time. When prolonged pressure causes tissue ischemia and the temperature drops to a preset threshold, a decompression mechanism is automatically activated to slowly release the tourniquet pressure. This effectively avoids irreversible ischemic damage to the distal limb caused by forgetting or failing to loosen the tourniquet in a timely manner, as is the case with traditional tourniquets. Simultaneously, it avoids rapid release at once, which could lead to sudden reperfusion injury to the ischemic stump tissue, causing local swelling and increased pain.

This invention relates to the field of medical device technology and provides a balloon, comprising: a balloon body; and occlusion rings. Multiple occlusion rings are spaced apart on the outer surface of the balloon body along its axial direction. Each occlusion ring has at least one through-hole penetrating its wall thickness. When the balloon body inflates, adjacent occlusion rings and the blood vessel wall together form a buffer cavity. The balloon provided by this invention has multiple occlusion rings on the outer surface of the balloon body, each occlusion ring having at least one through-hole penetrating its wall thickness. When the balloon body inflates, adjacent occlusion rings and the blood vessel wall together form a buffer cavity. This configuration allows blood pressure to be gradually reduced as it flows through the continuous buffer cavities after balloon inflates. High-pressure blood from the distal end of the balloon is buffered and depressurized, becoming low-pressure blood flow, achieving the effect of occlusion without complete blockage. This reduces significant blood loss and prevents ischemia and necrosis of downstream tissues.

The invention relates to the technical field of medical equipment, and particularly provides a pressure monitoring method and device, equipment and a medium. The method comprises the following steps: acquiring first overall pressure data in the artificial airway airbag, first local pressure data of a plurality of local areas on the surface of the artificial airway airbag and local blood perfusion data of tracheal mucosa corresponding to each local area; according to the obtained first overall pressure data and the first local pressure data, false pressure fluctuation caused by external mechanical interference of the connecting pipeline is recognized and eliminated, and corrected pressure data is obtained; according to the corrected pressure data and the local blood perfusion data, analyzing whether a local tissue ischemia risk exists or not; when it is analyzed that the local tissue ischemia risk exists, early warning information is sent out, and position information of a local area with the local tissue ischemia risk is provided; according to the method, the ischemia risk of the local tissue can be accurately predicted by acquiring multi-dimensional data and correcting pseudo pressure fluctuation in combination with local blood perfusion information.