218 results about "Blood loss" patented technology

The invention relates to a multi-parameter integration and AI fusion postpartum hemorrhage intelligent monitoring, prevention and control method and system. The method comprises the following steps: acquiring blood flow data; the blood flow data comprises blood loss volume and blood flow velocity, and the blood flow data is obtained through measurement of an optical fiber sensor; acquiring vital sign information; the vital sign information comprises blood pressure, heart rate and oxyhemoglobin saturation, and the vital sign information is obtained through continuous monitoring of a vital sign patch; according to the blood flow data, the vital sign information and the medical history information, a bleeding risk grade evaluation result is calculated in real time through an AI risk evaluation model, and the AI risk evaluation model is used for dynamically evaluating the bleeding risk; and triggering corresponding grading early warning according to the bleeding risk grade evaluation result, wherein the grading early warning is used for indicating bleeding risk processing. By adopting the method, the early warning accuracy and treatment efficiency of postpartum hemorrhage can be remarkably improved, and complications and death risks of pregnant and lying-in women are effectively reduced.

The invention features polypeptides that include an extracellular ActRIIA variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIA variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving low red blood cell levels, e.g., anemia or blood loss; fibrosis; or pulmonary hypertension.

Aspects of the disclosure provides composition and methods for treating a subject having a blood loss condition, the method comprising administering to the subject a hemojuvelin (HIV) antagonist (e.g., anti-HJV antibody).

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

The invention provides a thrombus aspiration catheter with a flow monitoring function. The device comprises a suction tube body, a suction handle, an ultrasonic flow sensing assembly, a processing unit and a display module, the ultrasonic flow sensing assembly is arranged at the far end of the suction pipe body and used for monitoring a blood flow signal at a suction opening of the suction pipe body. The processing unit is electrically connected with the ultrasonic flow sensing assembly and is used for processing the blood flow signal and calculating to obtain suction indication information; the display module is connected with the processing unit and is used for displaying the suction indication information; the suction indication information comprises blood flow information. Therefore, the blood flow near the suction port of the suction catheter can be obtained through monitoring of the ultrasonic flowmeter, whether the suction port is aligned with the thrombus or not and whether the thrombus is sucked into the catheter or not can be judged in an auxiliary mode, the thrombus can be sucked more accurately without unnecessarily drawing out blood, blood loss of a patient is reduced, meanwhile, the suction efficiency is improved, and the blood taking time is shortened. The treatment effect is improved.

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), fibrosis, and / or pulmonary hypertension.

The utility model discloses a thrombus aspiration plugging sheath system based on a special-shaped cavity, which comprises a vacuum device, an aspiration plugging sheath, an aspiration plugging sheath and an aspiration plugging sheath, and is characterized in that the vacuum device comprises a negative pressure needle cylinder and a piston buckle arranged on the side wall of the negative pressure needle cylinder; the balloon sheath tube comprises a tube body, a balloon used for blocking is arranged at the far end of the tube body, a connector connected with the vacuum device is arranged on the side of the near end of the tube body in a supporting mode, and a plurality of special-shaped cavities are formed in the tube body; the thrombus dragging instrument is used for blocking blood flow to reduce blood loss during thrombus suction and intercepting the thrombus to prevent the thrombus from escaping when the thrombus is dragged; the vacuum device is arranged on the side branch of the near end of the balloon sheath tube, and the thrombus dragging instrument is arranged in the balloon sheath tube. According to the embodiment of the utility model, the balloon filling opening and the thrombus suction opening are formed in the catheter body, a multi-cavity structure is adopted, the balloon sheathing canal blocks blood flow, and the thrombus dragging instrument is matched with a vacuum device to suck, drag and take out thrombus.

A stretcher including a flexible base panel sized to support a person lying thereon during a rescue or extrication operation. The base panel includes a header end and an opposite footer end, and further includes a plurality of securement straps, a shoulder harness, and a leg harness coupled to the base panel to help restrain the injured person and prevent further injury that may be caused such as by having the person roll off the sides of the stretcher. The leg harness may be configured to function as a junctional tourniquet to minimize blood loss at the pelvic region in the case of severe injury to the person.

The invention relates to the technical field of postoperative rehabilitation. The spine postoperative intelligent nutrition management method comprises the steps of performing multi-modal data fusion processing based on preoperative sign data, intraoperative blood loss and fluid loss amount and postoperative biochemical indexes of a patient to generate personalized nutrition requirement parameters; performing real-time monitoring and comparison processing on the postoperative diet intake of the patient through intelligent tableware provided with a weight sensor and an image recognition module according to the personalized nutritional requirement parameters, and generating a nutritional intake dynamic map; performing dynamic deviation analysis processing on detection data of the bioelectrical impedance analysis equipment and the saliva biomarker sensor to generate nutrition metabolism feedback data; and fusing the nutrition intake dynamic spectrum and the nutrition metabolism feedback data, carrying out nutrition intervention scheme optimization processing through a reinforcement learning model, generating a dynamic adjustment instruction, and pushing the instruction to a terminal, so as to achieve the technical effects of adapting to individualized requirements, tracking a metabolism state in real time and balancing nutrition intervention accuracy and safety.

The invention discloses a preparation method of a composite spray for improving the hemostatic ability of a wound part, the composite spray comprises a liquid A and a liquid B. The liquid B is a sodium alginate aqueous solution, a preparation method of the solution A comprises the following steps: 1, dissolving a lipopeptide conjugate, cholesterol, distearoyl phosphatidylcholine, distearoyl phosphatidylserine and dimethyl sulfoxide in a chloroform-methanol mixed solution to obtain a mixed system; 2, preparing the mixed system into a precursor solution by utilizing a film hydration method; 3, adding calcium chloride into the precursor solution, and reacting in a dark place to obtain a solution A; a precursor solution is designed according to the function of natural platelets, the function of the precursor solution is equivalent to that of nano platelets, the precursor solution is matched with sodium alginate, adverse effects on a blood coagulation system caused by fibrin degradation, platelet activation capability reduction and the like of a wound part due to blood loss can be relieved in a targeted manner, and the preparation has the advantages of rapid hemostasis, good biological activity, no toxic or side effects and the like. And the wound healing is rapid.

A system for reducing blood loss during removal of material from a body lumen includes an elongate shaft, an aspiration lumen, and a flow resistance assembly. The elongate shaft can be placed within a blood vessel and has a distal end with an opening at the distal end. The aspiration lumen extends along the shaft and has a proximal end and a distal opening. The flow resistance assembly is associated with the aspiration lumen and is configured to resist blood flow through the aspiration lumen in a free-flow condition without operating a valve in fluid communication with the aspiration lumen. The flow resistance assembly may include a coiled section of tubing, a static mixer, or flow resistance structures.

The invention discloses a clinical body fluid monitoring and early-warning device and a monitoring and early-warning method thereof, and relates to the field of medical instruments, the clinical body fluid monitoring and early-warning device comprises a shell, a shunting mechanism is mounted in the shell, and the shunting mechanism is connected with a monitoring mechanism. According to the clinical body fluid monitoring and early warning device and the monitoring and early warning method thereof, the gravity monitoring mechanism is adopted, the bleeding amount of a patient can be monitored in real time, a buzzer and a warning lamp are used in cooperation, medical staff can be warned when the bleeding amount of the patient reaches the dangerous blood loss amount, and the specific content is that the medical staff can conveniently monitor the bleeding amount of the patient. Drainage blood can be fed into a liquid storage bag to be stored under the action of a flow dividing pipe, a threaded connector, a connecting pipe and a connector, the weight of the blood stored in the liquid storage bag can be detected in real time and fed back to a controller under the action of a top plate, a first spring and a weighing sensor, and when the weight of the blood reaches a preset value, the controller is started. The controller controls the buzzer and the warning lamp to be started, and the warning effect on medical staff is achieved.

A networking-capable emergency tourniquet including an adjustable and inflatable cuff configured to encircle a limb of a patient, and a controller unit removably coupled to the inflatable cuff. The controller unit includes a microcontroller configured to control the introduction, removal, and maintenance of air within the inflatable cuff and process collected patient data, a communicator unit configured to communicate with the user, a transmitter configured to transmit the collected patient data to a centralized server over a communication network, and a receiver configured to receive information from at least one of the centralized server and other sources over the communication network.

The invention features ALK2 antibodies and antigen binding fragments thereof (e.g., ALK2 binding fragments). The invention also features pharmaceutical compositions and methods of using the ALK2 antibodies or antigen binding fragments thereof to treat bone disease or damage, low red blood cell levels (e.g., anemia or blood loss), heterotopic ossification (e.g., heterotopic ossification resulting from fibrodysplasia ossificans progressiva), Sjogren's syndrome (e.g., dry eye associated with Sjogren's syndrome), multiple osteochondroma, diffuse intrinsic pontine glioma, posterior capsule opacification, or cardiac hypertrophy and / or cardiac fibrosis.

The utility model relates to a blood pumping catheter and a ventricular assist system.The blood pumping catheter comprises a perfusion cavity, a perfusion pipeline, an elastic element and a first flow adjusting component, the far end of the perfusion pipeline is connected to the perfusion cavity, the elastic element and the first flow adjusting component are both installed on the perfusion pipeline, and the first flow adjusting component is located between the elastic element and the perfusion cavity; the first preset value is larger than or equal to zero, and the first flow adjusting component is in a cut-off state under the condition that the difference value between the near-end-side pressure of the first flow adjusting component and the far-end-side pressure of the first flow adjusting component is smaller than the first preset value. According to the embodiment of the invention, the blood loss of a patient can be reduced, and the risk of thrombus formation and blockage in the perfusion device and the blood pumping catheter is reduced, so that the operation stability and the operation life of the perfusion pipeline on the near end side of the perfusion device and the blood pumping catheter can be relatively improved.

The invention discloses an establishment method and application of a traumatic hemorrhagic sudden cardiac arrest rat model, a rat is used as an experimental subject, a researcher can accurately adjust the hemorrhagic degree in an animal model by controlling the bloodletting speed and amount to better control experimental conditions, the repeatability and reliability of experimental results are ensured, and the method has the advantages of being high in operability and high in reliability. In the model building process, not only is the factor of blood loss considered, but also tissue damage caused by laparotomy is combined, physiological changes under the combined action of multiple factors after trauma are reflected more comprehensively, and the complexity and authenticity of the model are improved; the method has the advantages that the operation is simple, the experiment cost is lower, the repeatability is high, the scale and frequency of cardiac arrest research experiments are not limited, the experiment result has higher reliability and generalizability, and the method not only can be used for basic medical research and exploration of the pathophysiology mechanism of traumatic hemorrhagic shock, but also is suitable for pharmacological research, and has a wide application prospect. The effectiveness of new drugs or therapies for improving prognosis is assessed.

The invention features polypeptides that include an extracellular ActRIIA variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIA variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving low red blood cell levels, e.g., anemia or blood loss; fibrosis; or pulmonary hypertension.

A method for estimating an amount of blood loss within a waste container of a medical waste collection system, wherein an imaging device is supported by a device holder. The method includes analyzing an image, such as image frames of a video stream, to determine a fluid volume and a blood composition within a waste substance. These images may be adjusted based on a reference marker, and the method includes segmenting the images to determine blood, meniscus, and non-blood categories. A fluid meniscus of the waste material may be identified and mapped to a canonical coordinate space for pixel-to-volume conversion. Calibration data associated with the reference marker may be used to achieve this. At least one region of interest associated with an insert disposed within a waste container is analyzed. The estimated amount of blood loss may be displayed in real time based on the determined fluid volume and blood composition.

The invention relates to the technical field of medical instruments, and provides a hemostasis valve structure and a sheathing canal assembly, and in the hemostasis valve structure, a valve body assembly is connected with a sheathing canal body. The two ends of the annular bag body are connected with the valve body assembly respectively, the middle of the annular bag body naturally droops, and the annular bag body is of a flexible inelastic bag body structure. And the liquid filling assembly is communicated with the annular bag body. When no instrument passes through the sheathing canal body, liquid is filled into the annular bag body through the liquid filling assembly, so that the annular bag body is expanded until the annular bag body is completely closed, and the sealing effect is achieved. When an instrument needs to be arranged in the sheathing canal body in a penetrating mode, liquid in the annular bag body does not need to be discharged, and the instrument can directly penetrate through the annular bag body in the expanded state. On one hand, operation is time-saving and labor-saving; on the other hand, due to the fact that the annular bag body is in the expansion state all the time, blood cannot flow out between the instrument and the annular bag body, and the blood loss risk is avoided.

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

Disclosed are methods, materials and devices for approximating blood volume in a fluid obtained from a subject, such as blood in a biological fluid collected during a surgical procedure. In particular applications, methods of estimating blood volume in a sample as part of a method for estimating blood loss from a subject are provided. The methods provide for a much accelerated technique for determining blood volume and / or packed red blood cell units in a sample (within about 5-10 minutes). The method and devices (canisters) may include a red blood cell (RBC) flocculant, such as polyDADMAC, and employ a formula that includes a value for an approximate blood hematocrit, and an approximate red blood cell packing ratio (“η”) for a collection container. A Blood Indicator Panel (BIP) is also disclosed that comprises a material and / or panel that may be placed alongside or on a collection device, the material and / or panel being suitable for inscribing / printing thereon a series of graduated markings calibrated to coincide with an approximate volume of blood and / or unit measure of packed red blood cells. The series of graduated markings correspond to a calculation of blood volume or red blood cell volume in a fluid sample, for example, according to a defined formula. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) methods of measurement are also disclosed. Methods for detecting blood and determining approximate blood volume in a sample (e.g., a fluid biological sample), and kits for performing the methods, are also provided.

The application discloses a kind of thrombus suction control method and thrombus suction device, and thrombus suction device includes suction assembly, suction assembly includes the shell with pressure cavity, piston rod and suction catheter, thrombus suction device also includes the motor of piston rod movement and the controller connected with motor, control method is: suction catheter is positioned to the blood vessel without thrombus, make motor operate according to speed V0, calibrate the pressure value B in pressure cavity under normal blood condition;Suction catheter is positioned to the blood vessel with thrombus, make motor operate according to speed V1, V1≤V0, make dynamic pressure value A0 in pressure cavity: when A0≤B, make motor keep speed V1 operation;When A0>B, make motor increase from speed V1: when B<A0≤C, make motor increase to speed V2 operation;When C<A0≤D, make motor increase to speed V3 operation;When D<A0≤E, make motor increase to speed V4 operation.The control method thrombus removal efficiency is high, and blood loss can be reduced.

The invention provides a carotid artery thrombus treatment catheter and a suction system comprising the same, and belongs to the technical field of medical instruments. The treatment catheter comprises a catheter body, a blocking balloon, a balloon pressurizing cavity and a Luer connector. The suction system comprises a Y-shaped connector, a blood transfusion module and a pressure monitoring system. Gapless wall attachment of the blood vessel wall is achieved through the blocking balloon, thrombus residues are avoided, suction-instrument conveying integrated operation is achieved in cooperation with the Y-shaped connector, and the multi-instrument exchange process is simplified; the balloon pressurizing cavity can accurately control the plugging balloon to expand to block blood flow, and thrombus fragments are prevented from being migrated; the peristaltic pump and the filter assembly of the blood transfusion module are connected through the catheter inner cavity, thrombus is sucked, filtered blood is transfused back, blood loss is reduced, the hemolysis risk is reduced, and the technical problems of thrombus residues, large blood loss amount, tedious operation, insufficient safety and the like are solved. The thrombus is efficiently removed, blood loss is remarkably reduced, the process is simplified, and the treatment safety is guaranteed through pressure monitoring.

The present invention discloses a track-type mechanical thrombus aspiration catheter, which belongs to the technical field of vascular interventional medical devices. It includes a suction catheter, in which a transmission shaft and an eccentric metal head are arranged; a metal connecting tube is arranged at the distal end of the suction catheter; an eccentric metal head is connected to the distal end of the transmission shaft, the center of mass of the eccentric metal head deviates from the rotation axis of the transmission shaft, and the eccentric metal head is located in the metal connecting tube. The suction catheter adopts an eccentric metal head structure, and the eccentric metal head makes an eccentric cone swing at the distal end of the suction catheter, which can increase the suction area of ​​the suction port through the eccentric setting, improve the suction force of the suction port, and at the same time, the eccentric cone swing crushing structure crushes the large thrombus near the suction port, reduces the thrombus blockage near the suction port, improves the thrombus aspiration efficiency, reduces blood loss, and reduces the operation time.

This invention discloses a method for preparing a composite spray that improves hemostasis at wound sites. The composite spray includes solution A and solution B, where solution B is an aqueous solution of sodium alginate. The preparation method of solution A includes: 1. Dissolving a lipopeptide conjugate, cholesterol, distearylphosphatidylcholine, distearylphosphatidylserine, and dimethyl sulfoxide in a chloroform-methanol mixed solution to obtain a mixed system; 2. Preparing a precursor solution from the mixed system using a thin-film hydration method; 3. Adding calcium chloride to the precursor solution and reacting it in the dark to obtain solution A. This invention designs the precursor solution based on the function of natural platelets, and its function is equivalent to that of nanoplatelets. Combined with sodium alginate, it can specifically alleviate the adverse effects on the coagulation system caused by blood loss, such as fibrin degradation and reduced platelet activation, at wound sites. It has the characteristics of rapid hemostasis, good bioactivity, and rapid wound healing.

The utility model relates to a thrombus aspiration device, and relates to the technical field of medical instruments, the thrombus aspiration device comprises a aspiration assembly, the aspiration assembly comprises an aspiration shell, a blood storage cavity is formed in the aspiration shell, a core rod is arranged on the aspiration shell, the core rod slides in the blood storage cavity, and along with the sliding of the core rod, the blood storage cavity is communicated with the blood storage cavity; negative pressure is formed in the blood storage cavity; the filtering assembly comprises a filtering shell, an outlet and an inlet are formed in the filtering shell, the outlet is communicated with the blood containing cavity, and the inlet is communicated with blood vessels of a patient; and the recovery assembly is communicated with the blood storage cavity, and the recovery assembly is used for recovering the sucked blood of the patient. According to the thrombus aspirator, the situation of excessive blood loss of a patient in the thrombus aspiration process is prevented.

A method and system for communicating estimated blood loss parameters of a patient to a user, the method comprising: receiving data representative of an image, of a fluid receiver; automatically detecting a region within the image associated with a volume of fluid received at the fluid receiver, the volume of fluid including a blood component; calculating an estimated amount of the blood component present in the volume of fluid based upon a color parameter represented in the region, and determining a bias error associated with the estimated amount of the blood component; updating an analysis of an aggregate amount of the blood component and an aggregate bias error associated with blood loss of the patient, based upon the estimated amount of the blood component and the bias error; and providing information from the analysis of the aggregate amount of the blood component and the aggregate bias error, to the user.

The invention discloses an open chest trauma treatment device which comprises a ring sleeve and further comprises an adjusting assembly used for stopping bleeding of a wound; the adjusting assembly comprises a thin tube, an air bag, an ejector rod A and a push plate, the air bag is fixedly connected to the thin tube, the air bag penetrates through the ring sleeve, one end of the ejector rod A is rotationally connected with the ring sleeve, a shaft is rotationally connected to the ejector rod A, the shaft is fixedly connected with an ejector rod B, the ejector rod B is hinged to the push plate, and the ring sleeve is connected with the pushing assembly; according to the invention, pneumothorax and blood loss can be effectively avoided.

The invention discloses a method for establishing a shock rat model with liver-spleen combined injury, which is characterized in that: on the basis of injury operation on the liver and spleen of a rat, when the liver and spleen of the rat are simultaneously injured, a blood loss intervention experiment is performed on the rat, so that the establishment of the shock rat model with liver-spleen combined injury is realized; the blood loss mode of the rat better conforms to the clinical blood loss condition, and the pathological process of the blood loss shock caused by the rat liver-spleen combined injury can accurately simulate the pathological process of the blood loss shock caused by the human body liver-spleen combined injury and is closer to the clinical practice; the device has the advantages that the treatment effect of a liver-spleen combined injury patient after blood substitutes are infused can be accurately simulated, and measures for coping with serious shock caused by liver-spleen combined injury can be conveniently and comprehensively studied.

An apparatus is configured to provide hemostasis with tissue removal in order to inhibit one or more of blood loss or tissue drainage. In many embodiments, a nozzle releases a liquid jet in a liquid medium in order to provide cavitation and a plurality of shedding pulses. The liquid jet, its cavitation and the plurality of shedding pulses can affect vascular tissue in order to promote clotting in order to inhibit bleeding. In many embodiments, vessels of the vascular tissue are affected at a distance from a region where cavitation of the water jet contacts the tissue. In many embodiments, the cavitation and plurality of shedding pules are related to a pulsatile shear wave propagating along the blood vessel that is related to clot promoting changes of the blood vessel.