The invention discloses a high-strength self-lubricating three-layer nested
medicine-carrying hollow cervical cerclage band with an auxiliary
miscarriage prevention function and a preparation method of the cerclage band, and belongs to the technical field of
medical instruments. Degradable
polyester monofilaments are woven into a hollow round
rope, and the hollow round
rope and a medical curved needle are integrated; then carrying out polydopamine-
polyethylene glycol double-layer modification on a
copper-based
metal organic framework (Cu-MOF), and loading active molecules; then mixing the
drug-loaded Cu-MOF with collagen natural
polymer sol, and uniformly filling the gel into the inner cavity of the round
rope and forming a three-dimensional bracket through synchronous drawing type micro-
perfusion and light-
enzyme synergistic cross-linking; then constructing a transient hydrated lubricating layer on the surface; and finally carrying out
ethylene oxide final sterilization to obtain a finished product. The cervical cerclage band device provided by the invention simultaneously provides degradable mechanical support,
collagen scaffold induction and long-acting slow release regulation, has a low-friction implantation characteristic, and can be well used for preventing or treating middle and late
abortion and premature delivery caused by cervical insufficiency.