67 results about "Embolization" patented technology

The invention relates to the technical field of image processing, and discloses a pulmonary embolism focus segmentation method and system based on image recognition, and a storage medium. The method comprises the following steps: extracting a multi-level blood vessel topological structure of a CTPA image through blood vessel diameter gradient analysis; modeling blood vessel density distribution by using a Weibull mixed model to obtain embolism characteristic parameters; the pixel embolism probability is estimated through variational Bayesian reasoning, and a focus distribution diagram is generated; performing multi-scale feature fusion on the lesion probability graph to obtain a segmentation boundary; and obtaining a final embolism focus segmentation result based on the vascular connectivity constraint optimization boundary. The problems that blood vessel level differentiation processing cannot be achieved, and accurate probability modeling and anatomical constraint verification are lacked are solved. The accuracy of pulmonary embolism focus segmentation is improved.

Disclosed herein are clot treatment systems including mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The method can further include moving the catheter proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then moving the catheter further proximally to deploy the embolic protection device at least partially proximal to the clot material. The clot treatment device can include one or more relief features configured to release captured clot material if the force on the clot treatment device exceeds a threshold.

Disclosed herein are clot treatment systems including mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The method can further include moving the catheter proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then moving the catheter further proximally to deploy the embolic protection device at least partially proximal to the clot material. The clot treatment device can include one or more relief features configured to release captured clot material if the force on the clot treatment device exceeds a threshold.

Disclosed herein are clot treatment systems including mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The method can further include moving the catheter proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then moving the catheter further proximally to deploy the embolic protection device at least partially proximal to the clot material. The clot treatment device can include one or more relief features configured to release captured clot material if the force on the clot treatment device exceeds a threshold.

The invention provides a pulmonary artery embolism imaging method, and relates to the field of magnetic resonance imaging. According to the specific implementation scheme, an acquisition window is determined according to electrocardio data and diaphragm navigation data of an adaptive patient; according to the collection window, original frequency domain data are collected in a Cartesian filling mode; performing phase compensation on the original frequency domain data by utilizing pulmonary artery pulse vector field modeling and a dynamic compensation algorithm to obtain proportionality coefficient spatial data; and performing compressed sensing reconstruction on the proportionality coefficient spatial data to generate a three-dimensional pulmonary artery image. The scheme is used for detecting pulmonary artery embolism in the free breathing state, no contrast agent is needed, radiation is avoided, and the universality of applicable people and the inspection safety are improved. According to the technology, by reducing artifact interference and optimizing image quality and scanning efficiency, rapid and accurate diagnosis is achieved, the comfort level of a patient and clinical diagnosis efficiency are remarkably improved, and the technology has important application value and social benefits.

The invention belongs to the field of biomedical materials, and particularly relates to a coagulation-promoting embolism microsphere and a preparation method thereof. The sericin-based embolism microspheres are creatively prepared, and the sericin membrane layer on the surface of the microspheres can prevent the risk that a catheter is solidified during an operation due to thrombin burst release during the operation. On the other hand, sericin in the microspheres has excellent water absorption swelling property and lubricity, and is beneficial to embolism and prevention of reflux; moreover, sericin molecules contain a large amount of hydroxyl and carboxyl, so that the chelation of blood coagulation factor calcium ions is greatly improved. In addition, thrombin factors are loaded into the microspheres, calcium ions are chelated on the surfaces of the microspheres, the microspheres are endowed with rapid embolism capacity through the superimposed effect, blood flow blocking of target blood vessels can be effectively accelerated, and reflux is prevented. The prepared procoagulant embolism microspheres are suitable for being applied to treatment of vascular-rich tumors of the brain and can effectively prevent mistaken closure of many complex functional blood vessels of the brain due to reflux.

The invention discloses a cryoablation catheter system for pulmonary artery stent internal restenosis, and belongs to the field of medical instruments, the cryoablation catheter system comprises a catheter main body arranged on a guide wire, the catheter main body is provided with a treatment assembly, the treatment assembly is located at the far end of the catheter main body, the catheter main body is provided with a control handle, and the control handle is located at the far end of the catheter main body. The control handle is located at the near end of the catheter body, and the treatment assembly comprises a near-end balloon, a far-end balloon and a freezing balloon. When the near-end balloon and the far-end balloon are simultaneously full, a closed treatment cabin isolated from near-end blood flow and far-end blood flow can be formed in a blood vessel of a target treatment section, the freezing balloon is located in the treatment cabin, the closed treatment cabin thoroughly eliminates the blood flow hot pool effect, cold is prevented from being taken away by the blood flow, and the treatment effect is improved. Freezing energy is intensively acted on a diseased region, so that the ablation efficiency and accuracy are improved; meanwhile, thrombus, tissue debris and whole body blood flow which fall off in the treatment process are isolated, the risk of far-end embolism is reduced from the source, and damage to the blood vessel wall is avoided.

The invention discloses a coated yttria-90 loaded radioactive microsphere and a preparation method and application thereof, and relates to the technical field of radioactive microsphere preparation, and the preparation method comprises the following steps: preparing a polyvinyl alcohol microsphere by using a microfluidic technology; the preparation method comprises the following steps: labeling polyvinyl alcohol microspheres with yttrium-90 radionuclide to obtain yttrium-90 loaded radiation microspheres; and coating the polylactic acid-glycolic acid copolymer on the surface of the yttria-90 loaded radioactive microsphere to obtain the coated yttria-90 loaded radioactive microsphere. The composite radioactive microspheres with uniform particle size, stable radioactivity and controllable characteristics can be obtained, and the composite radioactive microspheres are expected to be applied to transcatheter arterial radioembolism (TARE) treatment of liver cancer.

The application belongs to the technical field of biological detection, and discloses a cardiovascular marker control article and a preparation method thereof. The cardiovascular marker control article comprises a serum matrix, antigens, a preservative and a stabilizer. The antigens include cardiac troponin I antigens, creatine kinase isoenzyme antigens, myoglobin antigens, amino-terminal brain natriuretic peptide precursor antigens, brain natriuretic peptide antigens, D-dimer antigens, heart-type fatty acid-binding protein antigens, myeloperoxidase antigens and lipoprotein phospholipase A2 antigens. The stabilizer includes at least one of D-trehalose, sucrose, glycine, inositol and polyethylene glycol. The cardiovascular marker control article can cover various cardiovascular disease markers, including heart failure, pulmonary embolism, vasculitis and atherosclerosis, myocardial injury, myocardial infarction and the like. The control article can be used as a third-party control article for indoor and inter-laboratory quality control of a cardiovascular disease screening and auxiliary diagnosis measurement system.

The application discloses a method for constructing a 4D FLOW-based hemodynamic evaluation pulmonary embolism prognosis prediction model and application, relates to the medical image technology field, and comprises the following steps: collecting 4D-Flow images of patients who have been diagnosed with pulmonary embolism from medical institutions to obtain image data A; pre-processing the image data A, and dividing the pre-processed image data A into a training set and a verification set according to a proportion; respectively performing imageomic feature extraction, clinical feature extraction and 4D FLOW hemodynamic feature extraction on the training set and the verification set; screening the imageomic features and the clinical features and 4D FLOW hemodynamic detection indexes to obtain key features; and based on the key features, establishing a multi-omics prediction model for pulmonary embolism prognosis prediction, thereby providing a new imaging reference for pulmonary embolism treatment.

The invention belongs to the technical field of medicines, and particularly relates to application of penicillin tenuipes in preparation of a product for preventing or treating ischemic encephalopathy, cell experiments and animal experiments show that penicillin tenuipes has a good treatment effect on cerebral thrombosis and middle artery embolism, can obviously improve behavioral scores after ischemia, and can be used for preparing a medicine for preventing or treating ischemic encephalopathy. And cerebral thrombus and blood vessel diameter conditions. The penicillin tenuipes also has an anti-inflammatory effect. Therefore, the compound can be used for preparing medicines for preventing or treating ischemic encephalopathy.

The invention discloses an umbrella-shaped catcher for cardiac mucinoma, which comprises a net bag, an umbrella-shaped net bag, an umbrella-shaped net bag, an umbrella-shaped net bag, an umbrella-shaped net bag and an umbrella-shaped net bag, the rubber ring is arranged along the opening, is fixedly connected with the net bag and is used for shrinking the opening through self elasticity; the two adjusters are symmetrically arranged on the two sides of the net bag and connected with the outer wall of the net bag, and each adjuster comprises a sleeve and an adjusting rod; wherein the outer wall of the sleeve is connected with the net bag, one end of the adjusting rod is connected with the net bag, the other end of the adjusting rod penetrates through the sleeve and extends to the outside, and the adjusting rod can move relative to the sleeve in the axial direction so as to be used for dynamically adjusting the size of the opening. Therefore, the difficulty of surgical operation can be reduced, and the accidental risk of postoperative visceral organ embolism caused by the fact that the broken mucus tumor is left in the heart can be avoided.

Processes are provided based on an interventional (device-based) approach to minimize the development of intramyocardial hemorrhage within the myocardial infarction (MI) zone. In one exemplary process, the revascularization occurs in an incremental fashion prior to fully opening the vessel, so as to modulate the hydrostatic pressure transmitted from the proximal end of the catheter, prior to placing a stent. In another exemplary process, the stent will be placed within the central core of the embolization and will slowly expand within the lumen reaching full patency over a period of time. Devices operated with these processes can also greatly reduce the chance of development of intramyocardial hemorrhage with the MI zone. These developments can improve the outcome in hemorrhagic patients, who otherwise carry a significant risk for heart failure and sudden death.

The invention relates to the technical field of medical image processing, and discloses a liver cancer rupture bleeding embolism treatment curative effect image evaluation method and system, and the method comprises the steps: S1, obtaining enhanced CT image data of a patient after liver cancer rupture bleeding embolism treatment, carrying out the preliminary region division of a focus region of the enhanced CT image data, and carrying out the image segmentation of the focus region; obtaining a preliminary region division result; s2, when an interaction correction mark made by a user on at least one sub-region of the preliminary region division result is received, the preliminary region division result is adjusted in real time, the boundary of the adjusted sub-region is obtained, and the interaction correction mark indicates the real organization type of the sub-region; s3, circularly executing the step S2 to perform interactive iteration correction on the boundary of the sub-region until the user confirms a final division result; and S4, performing volume quantitative evaluation on different types of tissues of the final division result, and generating an evaluation report. According to the invention, misjudgment caused by fuzzy and overlapped image features is effectively avoided.

The invention relates to the technical field of health monitoring, in particular to venous thromboembolism monitoring equipment which comprises an evaluation module used for providing an evaluation scale, collecting filling information of a patient and generating a risk level evaluation result; the behavior guidance module is used for generating corresponding guidance suggestions based on the risk level assessment result, so that the patient can be protected according to the guidance suggestions; the monitoring module is used for collecting monitoring data in the protection process of the patient according to the guidance suggestions, and the monitoring data comprise leg circumference data, pain feeling data, skin color data, body temperature data, limb swelling data and pulmonary embolism expression data; and the early warning module is used for generating early warning information based on the monitoring data, and sending the early warning information to related medical personnel, so that manual monitoring is replaced by the monitoring equipment, the self-protection consciousness of the patient can be autonomously stimulated, the monitoring effect is improved, and the morbidity of venous thromboembolism is reduced.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

The application provides a method and device for recommending a hepatic cancer embolism placement point planning, wherein the method comprises the following steps: obtaining input data; segmenting the input data to obtain a segmentation result of the input data, and classifying the segmentation result to determine whether there is a high-risk tumor in the liver; if there is a high-risk tumor in the liver, calculating an embolism placement point according to the segmentation result, generating an embolism placement point planning result; synthesizing the embolism placement point planning result with an original medical image to generate a recommended scheme, and outputting the recommended scheme. Through deep learning, machine learning and traditional image processing methods, various organs such as patient arterial vessels, livers, tumors and bones are automatically segmented, and according to the automatically generated segmentation information, recommended information is generated to recommend the embolism placement point of each tumor, so as to assist doctors in comprehensively and deeply understanding the condition of the patient.

The present invention relates to a solid pharmaceutical dosage form for oral administration containing (4S)-2 4 -chloro-4-ethyl-7 3 -fluoro-3 5 -methoxy-3 2 ,5-dioxo-1 4 -(trifluoromethyl)-3 2 H-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzena-heptafane-7 4 -carboxamide (active ingredient (I)), characterized in that the active ingredient (I) is present in an amorphous form and is immediately released from the solid pharmaceutical dosage form for oral administration, a method for preparing the same, its use as a medicine, and its use for the treatment and / or prevention of diseases, particularly cardiovascular diseases, preferably thrombotic or thromboembolic diseases, and edema, and eye diseases. 【Chemical formula 1】 TIFF2026509613000011.tif37158

The invention relates to an application of Fgl2 gene knockout in antagonism of new coronavirus. In the technical scheme provided by the invention, a new crown infected mouse model is established through two SARS-CoV-2 mouse adaptive strains, namely, an MA17 strain and an MASCp36 strain, and it is verified that virus infection can promote Fgl2 expression up-regulation and fibrinogen deposition in mouse lung tissues; in addition, an SARS-CoV-2 mouse adaptive strain MA17 is utilized to infect an Fgl2 gene knockout mouse to prove that the Fgl2 gene knockout can antagonize lung inflammation infiltration, tissue damage, thromboembolism, fibrinogen deposition and fibrosis formation caused by virus infection, so that the occurrence of severe case and death of the mouse is reduced.

RNA interference (RNAi) agents for inhibiting the expression of Factor XI (FXI) are provided, as are pharmaceutical compositions comprising one or more FXI RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the FXI RNAi agent(s) to liver cells in vivo provides for inhibition of FXI gene expression and can provide for treatment of myocardial infarction, atrial fibrillation (AFib), deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, retinal artery occlusion, mesenteric ischemia, renal vein thrombosis, cerebral venous sinus thrombosis, venous thromboembolism due to deep vein thrombosis, and peripheral artery disease, as well as diseases and disorders associated with angioedema, thrombosis, and / or coagulation.

Described herein are methods for reducing or preventing blood flow in a neurovascular blood vessel of a subject. The method involves injecting a composition composed of water, one or more polycationic polyelectrolytes and anionic counterions, one or more one polyanionic polyelectrolytes and cationic counterions, and a statin, an anti-cancer agent, or a combination thereof, wherein the composition has an ion concentration that is (i) sufficient to prevent association of the polycationic polyelectrolytes and the polyanionic polyelectrolytes in water and (ii) greater than the concentration of ions in the subject. Upon introduction of the composition into a subject, a solid is produced in situ. The injectable compositions have unique distal penetration properties, which make the injectable compositions described herein very useful as embolics for neurovascular blood vessels.

The application provides a filter for breaking up thrombus. The filter comprises a power conversion mechanism, a filter support and a cutting mechanism which are connected in sequence along an axial direction and can be radially expanded and contracted; the power conversion mechanism and the cutting mechanism are axially limited and can rotate circumferentially relative to the filter support; the power conversion mechanism can convert the power of blood flow flowing from the cutting mechanism to the power conversion mechanism into rotary motion and can drive the cutting mechanism to rotate circumferentially in the filter support. According to the embodiment of the application, the cutting mechanism is driven by the power conversion mechanism to rotate circumferentially in the filter support, so that the thrombus intercepted in the filter support can be continuously cut and broken up, thereby avoiding pulmonary embolism and preventing blood vessel embolism caused by the filter for breaking up thrombus.

The invention relates to the technical field of hepatocellular carcinoma interventional therapy, in particular to hypoxia regulation type multi-stage embolism microspheres and application of the hypoxia regulation type multi-stage embolism microspheres to hepatocellular carcinoma treatment, the microspheres are mSiO2 / Pt / aPD-1 (at) HAMA composite embolism agents, a multi-stage embolism structure is formed by 100 [mu] m HAMA microspheres and 3 [mu] m mSiO2 microspheres, a Pt NPs catalytic oxygen production module and an aPD-1 immunotherapy module are loaded, and the microspheres are prepared through the microfluidic technology. The hypoxia regulation type multi-stage embolism microsphere can realize targeted embolism of different levels of blood vessels, dynamically regulate hypoxia and cooperate with immunotherapy, and the hypoxia regulation type multi-stage embolism microsphere is applied to liver cancer treatment, realizes full-blood-vessel network coverage, improves the embolism coverage rate, relieves hypoxia to enhance the immunotherapy effect, is high in biological safety and good in clinical compatibility, and provides an efficient solution for liver cancer treatment.

The application belongs to the technical field of medical devices, and particularly relates to an adhesive for treating varicose great saphenous vein and a preparation method thereof. The adhesive is obtained by the following steps: (1) preparation of poly cyanoacrylate powder; (2) preparation of the adhesive: 50-85 parts of cyanoacrylate, 5-30 parts of plasticizer, 0.01-0.5 parts of polymerization inhibitor and 0.01-0.5 parts of antioxidant are uniformly stirred, 10-30 parts of poly cyanoacrylate powder is slowly added, and stirring is continued until complete dissolution and filtration, and the adhesive is obtained. The prepared adhesive has a weight average molecular weight of 0.5-10 million, a viscosity of 500-3000 cp, low formaldehyde content, is not diluted by blood when implanted into a blood vessel, does not flow with blood, reduces the risk of ectopic embolism, reduces the risk of allergy and inflammation, and the adhesive has a curing time of less than 20 s, can quickly polymerize and form a clot to block the blood vessel when implanted into the target vein position.

The invention provides a hydrogel material with an effect of supporting tissue cell growth as well as a preparation method and application thereof, and belongs to the technical field of medicines. The hydrogel material is prepared from the following raw materials: povidone, polyvinyl alcohol, agar, boric acid, edible tannin and polyacrylic resin II. The preparation method comprises the following steps: mixing the raw materials with water to obtain a mixed solution, and then carrying out a cross-linking reaction on the mixed solution through electron beam irradiation to obtain the hydrogel material with the function of supporting tissue cell growth. The hydrogel material is applied to preparation of vascular embolism agents. The hydrogel can enable a body to generate histological reaction on the hydrogel serving as a foreign body, fibroblasts wrap the hydrogel and then grow into the hydrogel, cells migrate and proliferate to form collagenous fiber tissue of a three-dimensional network structure, and then capillary and tissue cells grow into the hydrogel to form connective tissue; meanwhile, under the action that cells swallow foreign matters, the hydrogel is digested and degraded, and finally the diseased tissues are repaired.

The application discloses a bullet-shaped polyvinyl alcohol embolism micro-particle and a preparation method thereof, and belongs to the field of non-spherical polymer micro-particle preparation. The embolism micro-particle is made of polyvinyl alcohol, and the overall shape is bullet-shaped, with a smooth joint between a hemispherical head and a cylindrical tail. The bullet-shaped polyvinyl alcohol embolism micro-particle is continuously prepared by using microfluidic technology, and the steps are as follows: (1) preparing modified polyvinyl alcohol macromolecules; (2) preparing a dispersed phase fluid, a continuous phase 1 fluid and a continuous phase 2 fluid; (3) preparing bullet-shaped non-spherical micro-particles by using a two-stage microfluidic device; and (4) storing the washed bullet-shaped polyvinyl alcohol embolism micro-particles in pure water. The bullet-shaped polyvinyl alcohol embolism micro-particle prepared by the application can effectively improve the flow characteristics and movement rate of the micro-particle in a channel, thereby improving the embolism effect of the micro-particle, and has important clinical application value for tumor embolism treatment.

The utility model relates to an integrated biopsy needle device which comprises a hemostasis assembly and a biopsy needle suite, the hemostasis assembly comprises a catheter and a plugging wire, the far end of the plugging wire can deform in response to different temperatures, and the plugging wire is in a first shape before entering a puncture channel by controlling the temperature of the plugging wire; after the plugging wire enters the puncture channel, the far end part of the plugging wire can be converted into the second shape in response to the temperature of the puncture channel, so that blood vessels on the inner wall of the puncture channel are extruded and coagulated, and direct use of the hemostatic filler is prevented; the hemostasis filler enters the puncture channel and then enters the inner wall blood vessel to cause ectopic embolism, and finally the plugging wire can be withdrawn by pulling the plugging wire towards the near end, so that the device is very convenient to use and is suitable for puncture channels with different inner diameters.

The invention discloses application of a compound high spot-nourishing tablet in preparation of a medicine for treating cerebral ischemia-reperfusion injury. A rat cerebral ischemia reperfusion injury model is established through middle cerebral artery embolism, and serum, pathology and infarction areas of rats are observed and detected. Results show that the neurological score of the model group ZeaLonga is significantly increased, pathological changes are large, proinflammatory factors TNF-alpha, IL-6 and IL-1beta are significantly increased, oxidation promoting MDA is significantly increased, and antioxidant SOD expression is significantly increased. And compared with a model group, the weight, the neurological score and the survival rate are obviously improved. The results of HE staining, TTC staining and TUNEL staining show that the nerve cell morphology, arrangement, infarct area and cell apoptosis condition of each administration group are obviously improved. The application provided by the invention can improve the behavior of rats, reduce the infarct area, protect nerve cells and reduce the apoptosis of ischemic regions; by reducing inflammation and oxidation in rat brain tissues, damage of inflammation and oxidative stress to the rat brain tissues is reduced.

Embodiments of the present specification provide a method for determining a pulmonary embolism index. The method comprises: obtaining a medical image of a subject, the medical image comprising pulmonary blood vessels of the subject, the pulmonary blood vessels of the subject comprising a thrombus; determining information related to the thrombus based on the medical image; dividing the pulmonary blood vessels into at least two hierarchical blood vessels based on the medical image; and determining a pulmonary embolism index of the subject based on the information related to the thrombus and the at least two hierarchical blood vessels.

Disclosed herein are devices, systems, and methods useful in facilitating the removal of thrombus, embolus, or debris from a blood vessel and other intravascular interventional actions, including proximal embolic protection when treating a vascular lesion or condition.