23 results about "Mechanical thrombectomy" patented technology

The invention relates to the technical field of medicines, in particular to application of DP-b99 and a derivative thereof in preparation of a medicine for treating cerebral ischemia mechanical thrombus extraction reperfusion injury. On the basis of mechanical thrombus extraction and reperfusion of cerebral ischemia, DP-b99 is combined to reduce mechanical thrombus extraction and reperfusion injury of cerebral arterial thrombosis, so that the inflammation level of brain tissues can be reduced, the volume of cerebral infarction can be reduced, the injury of the brain tissues can be effectively reduced, and the treatment effect is remarkable.

The present invention is entitled "Thrombectomy and Stent Implantation System". The present invention provides a design capable of both mechanical thrombectomy and stent implantation for the treatment of occlusions in the cerebral vasculature, which provides a three-catheter setup. A first outer catheter has the largest diameter and can serve as a guide catheter, while also serving as a sheath for the other catheters. A second deployment catheter can be configured for aspiration of the occlusion and can include a proximal stepped or recessed segment at the distal tip that can act as a housing for a woven expandable stent. The outer diameter of the stepped segment can be lined with an inflation device having a woven stent disposed on its top. Inside the second deployment catheter is a microcatheter that can deliver a mechanical thrombectomy device to the target site to retrieve the occlusion in the vessel, after which the stent can be expanded and implanted in the vessel.

This invention provides an interventional guidewire device for measuring intravascular oxygen saturation, belonging to the field of interventional surgical medical device technology. The guidewire device includes a guidewire body, a first oxygen measurement unit, and a second oxygen measurement unit. The guidewire body has a filamentous structure with a distal end and a proximal end. The first oxygen measurement unit is positioned at a predetermined distance from the distal end of the guidewire body and is used to measure oxygenation data at the distal end of the thrombus. The second oxygen measurement unit is positioned proximal to the first oxygen measurement unit and spaced at a predetermined distance from it, and is used to measure oxygenation data at the proximal end of the thrombus. During operation, the distal end of the guidewire body passes through the thrombus, with the first oxygen measurement unit positioned at the distal end of the thrombus and the second oxygen measurement unit positioned at the proximal end of the thrombus to measure oxygenation data at both ends of the thrombus. This invention primarily addresses the technical problem in existing technologies where it is impossible to assess oxygenation levels at the proximal and posterior ends of the thrombus before mechanical thrombectomy.

A mechanical thrombectomy device, and methods of manufacturing and using the mechanical thrombectomy device, are described. The mechanical thrombectomy device includes a support wire and a clot arrestor. The clot arrestor has an expandable frame that includes an interior wall defining a lumen. The support wire is coupled to a proximal end of the clot arrestor and extends through the lumen along the interior wall. Other embodiments are also described and claimed.

Disclosed herein are clot treatment systems including mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of a patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The clot treatment device can include a balloon catheter including an inflation port positioned on a proximal end of the balloon catheter and fluidly connected to a balloon on a distal end thereof. The balloon catheter includes an inflation control device fluidly connected to the inflation port, wherein the inflation control device is configured to reduce pressure within the balloon during inflation of the balloon.

A vascular therapy device (10) includes a retrieval device (12) configured to deploy an associated self-expanding stent (2) in a clot and including a retrieval line (14) attached to the associated self-expanding stent. At least one electronic processor (20) is programmed to: receive a time sequence of images (35) of the associated self-expanding stent acquired during a thrombectomy procedure in which the self-expanding stent is deployed in a clot; perform image analysis on the images of the time sequence of images to determine a geometric change of the associated self-expanding stent deployed in the clot; identify an event occurring in the thrombectomy procedure based on the geometric change of the associated self-expanding stent deployed in the clot; and respond to the identification of the event by: outputting an indication (36) of the event; and / or controlling a robot (16) to perform an action in response to the event.

To provide the treatment of ischemic stroke at risk of brain swelling using SUR1-TRPM4 channel inhibitors in combination with mechanical thrombectomy.SOLUTION: In some embodiments, the methods include treating patients suffering from a large hemispheric infarction. In certain embodiments, the patients have a lesion volume of less than 140 cm3 or less than 125 cm3 as measured by MRI DWI or CTP. The patient may have suffered a wake-up stroke. Some embodiments involve treating patients who also undergo decompressive therapy.SELECTED DRAWING: None

Improved systems including rBGCs improved by means of stiffness; working zones and optimized transition zones can traverse the aortic arch into the common carotid and vertebral arteries from a radial approach including navigation of tortuous and individuated anatomical challenges. Mechanical Thrombectomy improved by balloon occlusion prevents thrombus showers and follows 10 years of interventional cardiology and diagnostic use of improved radial approach (TRA) with better systems, making trans-femoral (TFA)less safe and effective than this revised treatment paradigm, unexpectedly better than literature predicted in early parts of the decade. Likewise, carotid stenting may be performed during these intracranial arterial occlusion procedures without swapping out guide catheters as required by the prior art.

This invention discloses a method and system for predicting the risk of malignant cerebral edema after mechanical thrombectomy in ischemic stroke, aiming to address the pain points of existing prediction tools, such as insufficient accuracy, lack of clinical interpretability, and difficulty in directly supporting decision-making. The core solution involves: stably extracting key predictive variables from multi-source clinical and laboratory data through a multi-algorithm consensus feature selection mechanism (LASSO, Boruta algorithm); employing eight machine learning algorithms to select the best high-performance prediction model, and using repeated cross-validation and grid search for robust optimization; innovatively and deeply integrating the SHAP interpretability framework to achieve global, local, and individualized interpretation of the model predictions; and finally deploying it as an integrated clinical decision support system, outputting a visual report that combines risk probability, risk classification, and decision-making basis. This method significantly improves the early risk identification capability of malignant cerebral edema, and the model exhibits excellent discrimination and calibration.

Disclosed herein are clot treatment systems including an integrated / systematic mechanical thrombectomy device and a clot treatment device, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of a patient includes inserting a catheter within the blood vessel proximate the clot material while radially constraining a clot handling device and an embolic protection device within the catheter. The method may also include moving the catheter proximally to at least partially deploy the clot treatment device to a distal side of the clot material within the blood vessel, and then further moving the catheter proximally to at least partially deploy the embolic protection device to a proximal side of the clot material.

A medical apparatus has a thrombectomy device disposed in a sheath lumen of a sheath that is movable between an initial extended position and a retracted position. The thrombectomy device includes a first elongate cannula having a distal tip, a guidewire lumen, and a perforated region, which is proximal to the distal tip and is in fluid communication with the guidewire lumen. A second elongate cannula, which is configured to rotate, has a second lumen and a mechanical thrombectomy whisk, which is proximal to the distal tip. A third elongate cannula has a third exterior surface, a third lumen, an inflation passageway, an inflatable balloon connected to the third exterior surface, and an expandable embolic filter connected to the third exterior surface at a location distal to the inflatable balloon. The first elongate cannula is disposed in the second lumen. The second elongate cannula is disposed in the third lumen.

The embodiment of the invention discloses a mechanical thrombectomy risk prediction system and method for elderly patients. The system comprises a database establishment module, a risk factor screening module, a model construction module and an embolectomy risk prediction module. According to the embodiment of the invention, for an advanced AIS-aLVO patient, on the basis of one-stop multi-mode CT information, by analyzing related collateral tract omics information, conventional image omics information and clinical data, risk factors influencing the advanced patient acute stage mechanical thrombus extraction poor prognosis are screened out, a Nomogram-based risk prediction model is constructed, and the risk prediction result of the advanced patient acute stage mechanical thrombus extraction poor prognosis is obtained. The generalization ability of the model and the clinical popularization feasibility are further verified through prospective queue research, and finally a set of mechanical thrombectomy risk assessment system for the elderly patients with acute precirculatory great vascular occlusion is established, so that more evidence-based basis is provided for preoperative decision making of clinicians; the individualized and precise diagnosis and treatment of the elderly ischemic stroke patient can be realized.

The invention discloses a large-diameter mechanical thrombus resection system and belongs to the field of medical instruments, the large-diameter mechanical thrombus resection system comprises a large-diameter catheter and a backflow mechanism mounted on one side of the large-diameter catheter, a resection mechanism is mounted in the large-diameter catheter, and a drug delivery mechanism is mounted in the resection mechanism; the cutting mechanism comprises a suction pipeline which is inserted into the large-diameter catheter in a sliding mode, and a guide wire is connected into the suction pipeline in a sliding mode; through cooperative use of all the devices, a guide wire and a suction pipeline are pulled to cut thrombus, an elastic filter screen is unfolded, the thrombus is limited, through arrangement of an air pump, an air suction pipe pumps out air in a sealing box, a connecting pipe and the suction pipeline are matched with each other, and the thrombus can be conveniently sucked out. Thrombus and blood in blood vessels are extracted, so that the thrombus collection effect is improved through mutual cooperation of mechanical cutting and extraction of the thrombus, and the situation that the thrombus is accumulated in the blood vessels due to incomplete collection is avoided.

The invention relates to the treatment of ischemic stroke at risk of brain swelling using SUR1-TRPM4 channel inhibitors in combination with mechanical thrombectomy. In some embodiments, the methods include treating patients suffering from a large hemispheric infarction. In certain embodiments, patients have a lesion volume of less than 140 cm3 or less than 125 cm3 as measured by MRI DWI or CTP. The patient may have suffered a wake-up stroke. Some embodiments involve treating patients who also undergo decompressive therapy.

This invention discloses a cerebral vascular targeted therapy and neuromodulation system based on magnetically controlled microcapsules, belonging to the field of medical device and neuromodulation technology. The system includes a magnetic navigation device, an alternating magnetic field generator, microcapsules, and a delivery catheter. The shell of the microcapsule is made of biodegradable hydrogel, internally loaded with magnetic nanoparticles and therapeutic drugs, and optionally, a contrast agent. The microcapsule is released into the vicinity of a targeted intracranial blood vessel through the delivery catheter. Under the combined action of a static magnetic field and a gradient magnetic field, the microcapsule navigates and positions itself within complex and tortuous small blood vessels. Subsequently, the alternating magnetic field drives the microcapsule to generate mechanical vibration or rotation, enhancing the contact and diffusion of local drugs with thrombi or lesions, improving the treatment efficiency for distal small vessel thrombosis, local infections, or tumors. When close to a specific brain region, the magnetomechanical or magnetothermal effects of the microcapsule can also provide controllable stimulation to local neurons, achieving high spatial resolution neuromodulation. Compared with traditional mechanical thrombectomy, systemic thrombolysis, and transcranial magnetic / electrical stimulation, this invention improves targeting and spatial accuracy while ensuring minimally invasiveness and reducing the risk of systemic side effects.

A device includes a catheter extending longitudinally from a proximal end to a distal end and including a lumen and a grasper. The grasper includes jaws connected such that the jaws are movable between an open configuration and a closed configuration. Also, the device includes a control member connected to the grasper so that a longitudinal movement of the member relative to the catheter moves the grasper between the configurations and a proximal interface including a piston connected to the proximal end so that, when the grasper is moved toward the closed configuration, the piston applies a negative pressure through the catheter to draw a separated portion of thrombus proximally therethrough.

A thrombectomy device (10) for blood clot removal has a first, proximal, end 5 and a second, distal, end. The thrombectomy device (10) has a main body portion (12) and a catheter (14) extending distally from the main body portion (12). The catheter (14) has an outer sheath (18) surrounding an inner wire (16). The inner wire (16) has a screw thread (20) on its outer surface. The inner wire (16) is rotatable about its longitudinal axis and can be moved relative to the outer sheath (18) and the main body portion (12) reciprocally between a first position proximal to the first end of the thrombectomy device (10) and a second position distal from the first end of the thrombectomy device (10). There is also described a catheter (14) for connection to a main body portion of a thrombectomy device (10).

The invention is entitled "Dual Layer ICAD Device". The invention provides a design that combines mechanical thrombectomy and stent implantation together to more effectively treat occlusive and stenotic lesions in the cerebral vasculature, the design features a dual layer of equipment. The outer layer consists of a deployable stent cage with large cell openings that can allow thrombus to pass through the openings into the inner layer of deployable capture segments. The clot capture segments can be configured to pinch and extract occlusions. The outer cage is configured to detach from the rest of the device and remain implanted as a stent to exert outward radial force to support and / or dilate a stenotic region. The device can have a distal debris protection element to prevent distal migration of elements released during the procedure.

The invention relates to the treatment of ischemic stroke at risk of brain swelling using SUR1-TRPM4 channel inhibitors in combination with mechanical thrombectomy. In some embodiments, the methods include treating patients suffering from a large hemispheric infarction. In certain embodiments, patients have a lesion volume of less than 140 cm3 or less than 125 cm3 as measured by MRI DWI or CTP. The patient may have suffered a wake-up stroke. Some embodiments involve treating patients who also undergo decompressive therapy.

Disclosed herein are clot treatment systems including mechanical thrombectomy devices and clot treatment devices, and associated devices and methods. In some embodiments, a method of removing clot material from a blood vessel of patient includes inserting a catheter to proximate the clot material within the blood vessel while radially constraining a clot treatment device and an embolic protection device within the catheter. The method can further include moving the catheter proximally to deploy the clot treatment device at least partially distal to clot material within the blood vessel, and then moving the catheter further proximally to deploy the embolic protection device at least partially proximal to the clot material. The clot treatment device can include one or more relief features configured to release captured clot material if the force on the clot treatment device exceeds a threshold.

Provided herein are methods of enhancing mechanical thrombectomy during endovascular therapy for acute thrombosis using 3,3′-diindolylmethane.

The application discloses a brain perfusion parameter prediction blood vessel recanalization grade method and system, and belongs to the technical field of medical image processing. The method comprises the following steps: acquiring a preoperative CTP parameter map and a CTA maximum density projection reconstruction map of an acute large blood vessel occlusive stroke patient and a dynamic scanning sequence of CTP scanning; extracting functional perfusion features from a CTP channel and morphological structure features from a CTA channel through a multi-modal feature fusion network; extracting a collateral compensation vector based on a CTP dynamic sequence through a pre-constructed collateral circulation embedding module; modeling six discrete grades into an ordered category by using an mTICI hierarchical ordered regression prediction head of a cumulative link model; and modulating a prediction output by the collateral compensation vector through an attention gate mechanism, and outputting an mTICI grade prediction probability distribution. The application realizes preoperative prospective prediction of an mTICI grade after mechanical thrombectomy.