98 results about "Cerebral infarction" patented technology

The invention discloses a nasal delivery multistage targeting bionic nano drug delivery system as well as a preparation method and application of the nasal delivery multistage targeting bionic nano drug delivery system. According to the drug delivery system, a black phosphorus nanosheet with an active oxygen scavenging effect is used as an inner core carrier, a neuroprotective agent fingolimod hydrochloride FTY720 and polydimethyldiguanide PolyMet are loaded, and a microcolloid cell membrane and a mitochondrial membrane are modified on the surface of the preparation; the nano drug delivery system is applied to treatment of cerebral arterial thrombosis reperfusion injury, can overcome the blood brain barrier, can quickly enter the brain through nasal administration, realizes efficient delivery of drugs, remarkably reduces the cerebral infarction area, reduces the brain inflammation level, protects nerve cells, greatly relieves cerebral arterial thrombosis reperfusion injury, and has application prospects.

The invention relates to an accurate evaluation and dynamic optimization system for cerebral infarction ultra-early reperfusion treatment, in particular to the field of biomedicine.Heterogeneous image data are fused through multi-center federal learning, and a high-robustness standardized brain characteristic spectrum is constructed; the real-time physiological parameters are utilized to drive the dynamic graph network, and the pathological process of the ischemic penumbra evolved along with time is accurately simulated; a core infarction zone and half-dark band probability graph with reasonable spatial distribution is generated by introducing a multi-task classifier with mutual exclusion constraints; and finally, a virtual contrast perfusion image is generated in combination with the individual blood vessel conditions of the patient to perform personalized calibration, so that the accuracy and individualization level of the delineation of the penumbra are remarkably improved, more reliable and dynamic decision support is provided for a clinician to formulate an ultra-early reperfusion treatment scheme, and the risk of insufficient treatment or excessive treatment is effectively avoided.

This invention discloses a data processing method and system based on the changing trends of image features, relating to the field of cerebral infarction early warning technology. The data processing method includes: feature extraction: processing image data and modal data separately using feature analysis methods to obtain image features, image feature change data, modal data features, modal data feature change data, and the regions where the features are located. In this invention, image data provides intuitive information about brain structure and lesions, while modal data supplements key features such as hemodynamics, brain tissue electrical activity, and electrical impedance from different physiological dimensions. TCD data can monitor blood flow velocity and vascular resistance in real time, BI data is sensitive to changes in pathological states such as cerebral edema, and EEG data reflects subtle changes in neuronal electrical activity. Through feature extraction and analysis, the combination of multi-source heterogeneous data achieves the correction of image feature changing trends, thereby ensuring the accuracy of data processing.

The invention discloses a medicine formula for preventing cerebral infarction and promoting rehabilitation and a preparation method thereof, and belongs to the technical field of preparation of medicines for preventing cerebral infarction, the medicine formula comprises the following raw materials by weight: 10-15 parts of flatstem milkvetch seed, 10-15 parts of dodder, 10-15 parts of tortoise plastron, 10-12 parts of red peony root, 6-9 parts of safflower, and 15-30 parts of red sage root. According to the invention, the flatstem milkvetch seed, the semen cuscutae and the tortoise plastron are used for nourishing liver and kidney, replenishing essence and benefiting marrow, so that the traditional Chinese medicine theory that kidney dominates bone marrow generation and brain is marrow sea is met, and brain function decline is improved from the source; meanwhile, the radix salviae miltiorrhizae, the radix paeoniae rubra and the flos carthami have the effects of promoting blood circulation to remove blood stasis, activating meridians to stop pain, effectively improving brain microcirculation, inhibiting platelet aggregation and reducing blood viscosity, and supplement each other to achieve the effects of strengthening the body resistance to eliminate pathogenic factors and treating both symptoms and root causes, so that the traditional Chinese medicine composition can be used for preventing cerebral infarction of high-risk groups and is also suitable for functional recovery in the rehabilitation period after cerebral infarction.

The invention relates to an endocavitary interventional operation device which comprises a first sheath assembly, a second sheath assembly and an umbrella protection assembly, the first sheath assembly comprises a protection umbrella and a first sheath tube, and the protection umbrella is connected to the far end of the first sheath tube; the umbrella protection assembly is detachably connected to the near end of the second sheath assembly, the first sheath tube can axially and movably penetrate through the umbrella protection assembly and can drive the protection umbrella to retract into the umbrella protection assembly, and when the umbrella protection assembly is connected with the near end of the second sheath assembly, the first sheath tube can push the protection umbrella from the umbrella protection assembly to the second sheath assembly. According to the endocavitary interventional operation device, the umbrella protection assembly is used for guiding the protection umbrella to smoothly enter the second sheath tube from the near end of the second sheath assembly, operation convenience and safety are provided, thrombus and plaques in a blood vessel are captured in the whole process through the protection umbrella, and the cerebral infarction occurrence rate is reduced.

The invention belongs to the technical field of biological medicine. More specifically, the invention provides the annular RNACircMAP2, and the sequence of the annular RNACircMAP2 is as shown in SEQ ID NO. 1 or SEQ ID NO. 2. The invention proves that CircMAP2 can be used as a novel biomarker for diagnosing acute ischemic stroke for the first time. Compared with a traditional imaging diagnosis method, the acute ischemic stroke can be diagnosed by detecting the expression level of the CircMAP2 in the plasma and the plasma exosome of the patient, the cerebral infarction area of the acute ischemic stroke can be speculated through the expression level of the CircMAP2, and the method has the advantages of being easy and convenient to operate, high in detection speed and low in cost; the system is especially suitable for popularization and use in primary medical institutions. The product for diagnosing acute ischemic stroke provided by the invention can quickly and accurately diagnose acute ischemic stroke, and has good clinical popularization prospect and application value.

The invention relates to a ligand targeting neutrophil and neurons as well as a preparation method and application of the ligand. The ligand for targeting the neutrophil and the neuron is prepared from the following raw materials in parts by weight: 30 to 50 parts of DSPE-PEG-Tet1, 2 to 3 parts of ketal thiol with carboxyl groups at two ends and 30 to 50 parts of a neutrophil targeting ligand, the neutrophil targeting ligand is one or more of sialic acid, an anti-CD66b antibody, an anti-CD177 antibody, an anti-CD16b antibody, N-formylmethionine peptide (fMLF) and an analogue thereof, a CXCR1 / CXCR2 binding peptide, an integrin binding peptide, a selectin ligand and lectin. According to the invention, sequential targeting of neutrophile granulocytes-neurons can be realized, target cells of ischemic lesions can be accurately protected, and the improvement effect on the cerebral infarction area of MCAO rats can be obviously enhanced.

The invention discloses a cerebral infarction risk early warning method and system based on an image feature change trend, and relates to the technical field of cerebral infarction early warning. The cerebral infarction risk early warning method comprises the steps of feature extraction, wherein image data and modal data are processed through a feature analysis method, and image features, image feature change data, modal data features, modal data feature change data and regions where the features are located are obtained; the image data provides visual information of a brain structure and a focus, the modal data supplements key features such as hemodynamics, brain tissue electrical activity and electrical impedance from different physiological dimensions, the TCD data can monitor blood flow velocity and vascular resistance in real time, and the BI data is sensitive to change of pathological states such as encephaledema. The EEG data reflects the subtle change of the electrical activity of neurons, and the image feature change trend is corrected through feature extraction and analysis and combination of multi-source heterogeneous data, so that the accuracy of cerebral infarction risk early warning is ensured.

The invention relates to the technical field of medical equipment and signal processing, in particular to a cerebral infarction thrombectomy postoperative intracranial pressure management method and system based on fNIRS-TCD combined monitoring, and the method comprises the steps: firstly, synchronously collecting fNIRS cerebral blood oxygen concentration change data and TCD cerebral blood flow velocity data through a head-mounted device, and calculating a pulsation index; then, on the basis of a Bayesian data assimilation framework, constructing the data into a real observation vector, combining a state vector predicted by an intracranial physiological model and an observation vector predicted by an observation model, calculating a Kalman gain through an iterative integrated Kalman algorithm, and further correcting the state vector in real time; and obtaining state estimation containing precise intracranial pressure. And finally, the system carries out three-level early warning according to the real-time intracranial pressure data in combination with brain blood oxygen and pulsation index changes, and carries out stepped individual management from observation, drug intervention to emergency rescue according to the three-level early warning. According to the invention, the intracranial pressure management accuracy is improved.

The invention relates to the technical field of medicines, in particular to application of DP-b99 and a derivative thereof in preparation of a medicine for treating cerebral ischemia mechanical thrombus extraction reperfusion injury. On the basis of mechanical thrombus extraction and reperfusion of cerebral ischemia, DP-b99 is combined to reduce mechanical thrombus extraction and reperfusion injury of cerebral arterial thrombosis, so that the inflammation level of brain tissues can be reduced, the volume of cerebral infarction can be reduced, the injury of the brain tissues can be effectively reduced, and the treatment effect is remarkable.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to a PSD-95 PDZ2 peptidomimetic inhibitor and application thereof. A series of compounds are designed and synthesized by taking a tetrapeptide ETAV as a template, a structure-activity relationship of the compounds with PSD-95 PDZ2 is systematically studied, and an optimal compound 32-2, i.e., the PSD-95 PDZ2 peptidomimetic inhibitor, is screened, a structural formula of which is shown as formula (I), the PSD-95 PDZ2 peptidomimetic inhibitor has very excellent plasma stability, and exhibits significant neuroprotective activity in in-vivo and in-vitro biological activity evaluation, significantly reduces cerebral infarction caused by cerebral ischemia-reperfusion injury, and can be used for preparing a drug for treating ischemic stroke. (I).

Provided are a fluorine-18-labeled positron emission tomography (PET) radiotracer for diagnosing neuroinflammation, stroke or cerebral infarction and a method for diagnosing cancer in a subject including administering a fluorine-18-labeled PET radiotracer a subject, obtaining in vivo PET images of the uptake of the fluorine-18-labeled positron emission tomography (PET) radiotracer in a lesion in the subject, and evaluating the uptake of the fluorine-18-labeled radiotracer in the lesion.

A protein polymer and a production process therefor. The protein polymer is obtained by means of stimulating MSCs, lysing same, and separating and purifying same. The protein polymer has a strong capability to repair oxidative damage, and thus can reduce the range of cerebral infarction, improve neural functions, inhibit the level of neuroinflammation, and increase the number of surviving neurons.

The present invention relates to a composition comprising a complex extract of Coptis japonica, Phellodendron Chinensis, Scutellaria baicalensis, Gardenia jasminoides, and Rheum palmatum. The composition was confirmed to: reduce the levels of blood cholesterol, blood lipids, and blood LDL-cholesterol in patients with dyslipidemia; reduce systolic blood pressure without affecting diastolic blood pressure and pulse rate in patients with hypertension; reduce the level of pulse wave velocity (PWV), which is an indicator of arteriosclerosis, in patients with atherosclerosis, and inhibit the recurrence rate for up to 5 years in patients with cerebral infarction. Accordingly, the composition is provided as a therapeutic agent for dyslipidemia, hypertension, arteriosclerosis, or cerebral infarction. In particular, the composition is made into an encapsulated form rather than conventional decoctions, to reduce the content of geniposide, which is reported as a side effect component, and thus an optimal composition which maintains efficacy against dyslipidemia and does not cause side effects is provided.

The invention provides application of levosimendan in preparation of a medicine for treating permanent cerebral infarction. Experiments prove that levosimendan can reduce the cerebral infarction volume of permanent cerebral infarction and increase cerebral blood flow after the permanent cerebral infarction. The invention provides a brand new strategy for treatment of permanent cerebral infarction, and has a wide clinical application prospect.

The application belongs to the technical field of medicine, and particularly relates to a muscone derivative, a preparation method and application thereof. The muscone derivative cyclopentadecanedione monoxime has obvious advantages over muscone and other derivatives in improving the MCAO rat mNSS score, microcirculation blood flow, reducing the cerebral infarction rate, the cortical and hippocampal neuron necrosis rate, and the brain water content, and increasing the SOD and CAT contents of the rat brain tissue which are abnormally reduced due to ischemia, and is a potential effective drug for cerebral ischemia-reperfusion injury.

The present application relates to a death receptor 5 (DR5) domain variant. The present application further relates to a fusion protein containing the DR5 domain variant, which has one or more of the following properties: (1) the ability to bind to TRAIL, (2) blocking apoptosis induced by the TRAIL / DR5 pathway, (3) reducing the size of myocardial infarction in cardiac ischemia and / or ischemia-reperfusion, and (4) having a protective effect against cerebral infarction. The present application further provides a method for producing the fusion protein and uses thereof.

The invention belongs to the technical field of biological medicines, and relates to a high-throughput screening method based on cell membrane nano-vesicles and application of a screened drug afloqualone in resisting encephaledema. Through a screening model, it is surprisingly found that the drug afloqualone AFQ on the market has the remarkable effect of inhibiting water inflow and encephaledema. The glibenclamide pharmaceutical composition shows a curative effect superior to that of glibenclamide in an animal model, can effectively reduce the volume of cerebral infarction, reduce the death rate in an acute stage and improve neurological impairment, and is known to have good clinical safety and good clinical application prospects. The invention provides a brand-new treatment strategy with a great clinical application prospect for solving the problem of lack of effective medicines for post-stroke encephaledema at present.

The application provides a cerebral infarction lesion detection method and device and a storage medium, and belongs to the technical field of lesion detection. The method comprises the following steps: obtaining original CT image data of a cerebral infarction patient and original MRI image data of the cerebral infarction patient from a preset hospital picture archiving system; introducing original boundary box coordinates; and respectively preprocessing the original CT image data of the cerebral infarction patient, the original boundary box coordinates and the original MRI image data of the cerebral infarction patient to obtain preprocessed boundary box coordinates and a cerebral infarction patient image data set. The application can effectively improve the detection precision and generalization of cerebral infarction lesions, improve the positioning precision of small target lesions, realize end-to-end lesion positioning, and realize full-automatic lesion positioning.

The application discloses application of a 2-amino-pyrazine derivative in preparation of a medicine for treating and / or preventing apoplexy and complications, wherein the 2-amino-pyrazine derivative iMAP4K1 is (R)-4-[5-amino-6-[[1-(1-methyl-4-piperidyl)-4-pyrazolyl]oxy]-2-pyrazinyl]-N-[2-(3-fluoro-1-pyrrolidinyl)ethyl]-2,6-dimethylbenzamide; the apoplexy is acute ischemic stroke; and the 2-amino-pyrazine derivative can be used as an active ingredient in a medicine for treating and / or preventing post-stroke brain injury and complications, effectively reducing post-stroke cerebral infarction volume, improving sensory-motor and balance nerve functions, and preventing and treating post-stroke complications such as cerebral edema and acute lung injury.

The present disclosure relates to a method and system for acquiring and analyzing physiological signals of a subject to detect the risk or occurrence of stroke or cerebral infarction. A wearable wireless device may be used with one or more electrode clusters to record physiological signals during a sleep-wake cycle. The physiological signal may be utilized to perform sleep and wakefulness analysis. In some examples, physiological signals corresponding to each hemisphere of the brain may be compared, e.g., using coherence, to quantify asymmetry across the hemispheres and identify possible stroke, asymptomatic cerebral infarction (SBI), or aneurysm. Biomarkers may be extracted based on sleep and wakefulness analysis as well as coherence. Biomarkers may include an indication of obstructive sleep apnea or apnea risk, a reduction in slow wave sleep duration, or the presence of SBI or aneurysm. A stroke risk score may be generated from the biomarkers using a predictive model for the early detection of individuals that are potentially at risk of stroke.

The invention discloses a traditional Chinese medicine formula for treating cerebral infarction, three highs and hyperuricemia and a preparation method thereof. The composition comprises 48 medicinal materials such as radix astragali and radix salviae miltiorrhizae, and combined treatment of multiple diseases is achieved through the synergistic effect of tonifying qi, activating blood, dredging collaterals and descending turbidity. The preparation method adopts ceramic membrane filtration and low-temperature spray drying processes, and the retention rate of active ingredients is increased by 30%. An embodiment verifies that the traditional Chinese medicine composition can be prepared into tablets, granules and other dosage forms, can synchronously improve neurological functions and metabolic indexes through clinical verification, and has high efficiency and safety.

The invention discloses a traditional Chinese medicine monomer nanoparticle oral delivery system based on intestinal liver circulation and a preparation method thereof, spherical nanoparticles (SA NPs) with the particle size of 194 + / -20 nm are formed through self-assembly of threat resin acid (SA), and the limitation of a traditional nano carrier is broken through: the oral bioavailability reaches 34.7% by utilizing an ASBT-mediated intestinal liver circulation mechanism; the gastric acid environment is tolerated (the pH is stable at 1.5), and after penetrating through the intestinal epithelium, the drug is targeted to ischemic brain tissues; the medicine has carrier-medicine dual functions, and the cerebral infarction volume is reduced by 34.1% when the medicine is singly used; after the neuroprotective peptide NA1 is loaded (the drug loading capacity is 5.8 wt%), the infarct volume is reduced by 68.7% through synergism. The system is suitable for pre-hospital first aid of cerebral apoplexy, and the freeze-dried powder can be stored at normal temperature for 12 months. The delivery system has a great application prospect in preparation of drugs for treating acute ischemic stroke needing rapid brain targeting.

The application relates to the technical field of medicines, and particularly discloses a polypeptide and application of the polypeptide in preparation of a medicine for ischemic stroke. The amino acid sequence of the polypeptide is as shown in SEQ ID NO. 1. The polypeptide can significantly improve the nerve function defect of a mouse transient middle cerebral artery occlusion / reperfusion (tMCAO / R) model in vivo, reduce the cerebral infarction volume, and reduce the whole-body oxidative stress level. In vitro, the polypeptide has a direct protective effect on HT22 cells of mouse hippocampal neurons and hCMEC / D3 cells of human brain microvascular endothelium induced by oxygen-glucose deprivation (OGD), can resist the damage of corticosterone and MPP + induced PC12 cells, and effectively inhibits the accumulation of reactive oxygen species (ROS) in cells. The results show that the polypeptide has a multi-target cell protection activity, can play an anti-ischemic stroke role from multiple dimensions such as reduction of infarction volume, inhibition of oxidative stress level, and protection of nerve vascular units.

The invention discloses a cerebral infarction patient swallowing function rehabilitation intelligent training instrument, and relates to the technical field of swallowing function rehabilitation training instruments, the cerebral infarction patient swallowing function rehabilitation intelligent training instrument comprises a ferrule and a connecting plate, an adjusting box is fixedly installed between one sides of the outer walls of the ferrule, a driving motor is fixedly installed at the bottom of the inner wall of the adjusting box, and a driving rod is fixedly installed on one side of the outer wall of the driving motor. According to the scheme, a driving motor is started to drive a driving rod and a gear to rotate, so that a tooth row is driven to move up and down in an adjusting box, a connecting column is driven to move up and down along a rectangular hole, and the adjusting box and the lower jaw can be dragged to a proper height so as to adapt to lifting of the lower jaws of different patients; then through the action of two first limiting grooves, two first sliding blocks and a connecting block, a screw rod with a handle is rotated to drive the connecting block and the lower jaw support to move front and back, the requirements of different patients for lower jaw support are further met, and the swallowing function rehabilitation training effect on the cerebral infarction patient is improved.

The external application medicine bag is prepared from the following raw materials in parts by weight: 6 to 8g of flos carthami, 5 to 7g of ground beetles, 7 to 9g of leeches, 5 to 6g of akebia stems, 8 to 10g of herba taxilli, 6 to 8g of gadflies, 5 to 7g of sappan wood, 8 to 10g of radix salviae miltiorrhizae, 6 to 9g of radix paeoniae rubra, 5 to 7g of native copper, 7 to 9g of catechu, 8 to 10g of fossil fragments, 6 to 8g of oysters and 7 to 9g of rhizoma gastrodiae. The traditional Chinese medicine bag has the beneficial effects that the traditional Chinese medicine bag has comprehensive conditioning effects of dredging meridians and collaterals, removing stasis and blocking and reducing blood viscosity, can effectively prevent cardiovascular and cerebrovascular diseases through long-term local external application according to a treatment course, and has an auxiliary treatment effect on various common diseases such as hypertension, insomnia, anxiety, cerebral infarction and lumbar disc herniation; it is worth mentioning that by means of the three-dimensional structural design of the paper folding tea bag, the dissolution efficiency of effective components is remarkably improved, meanwhile, the packaging size is reduced by 60%, and the tea bag is more environmentally friendly and portable; meanwhile, through a standardized preparation process, the use convenience and safety can be taken into account on the basis of ensuring stable release of the drug effect.

The present invention relates to a composition containing gintonin as an active ingredient for the prevention and treatment of ischemic cerebrovascular disorders, including cerebral infarction. The gintonin of the present invention can reduce the volume of cerebral infarction and increase survival rates after cerebral infarction, making it useful for the prevention and treatment of cerebral infarction. Furthermore, pretreatment of human brain microvascular endothelial cells (HBMECs) with gintonin has been shown to have neuroprotective and injury-preventing effects, while posttreatment with gintonin has been shown to have neuroprotective and therapeutic effects. Mechanism verification revealed that gintonin is effective in restoring reduced nitric oxide (NO) levels, which are known to be involved in the onset and pathophysiology of cerebral infarction. Therefore, the use of the present invention may improve the prevention and treatment of ischemic cerebrovascular disorders, including cerebral infarction, and reduce medical costs.

This invention provides a traditional Chinese medicine compound preparation and its application in the preparation of drugs for treating cardiovascular and cerebrovascular diseases, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine compound preparation comprises the following raw materials in parts by weight: 10-20 parts bee pollen, 8-15 parts curcumin, 5-10 parts γ-aminobutyric acid, 5-12 parts Litsea cubeba leaf, 10-20 parts hawthorn, 5-10 parts Lindera strychnifolia leaf, 10-20 parts kudzu root, 5-12 parts ginseng, 8-15 parts Polygonatum sibiricum, 6-12 parts Sophora japonica flower bud, 3-8 parts tangerine peel, and 1-5 parts L-cysteine. This invention significantly improves the water solubility, stability, and bioavailability of curcumin by constructing a chlorophyll zinc / LDH nanosheet composite carrier to load curcumin. A compound preparation of traditional Chinese medicine was prepared by combining a complex loaded with curcumin with various food and medicine homologous ingredients. This traditional Chinese medicine compound preparation can significantly reduce whole blood viscosity, plasma viscosity and platelet aggregation rate in rats with acute blood stasis model, has anti-thrombotic effect, and significantly promotes the recovery of neurological function in rats with focal cerebral ischemia and reduces the volume of cerebral infarction.

The invention discloses an application of picrogenin A in preparation of a medicine for treating ischemia-reperfusion injury. The invention proposes and verifies that the kuichnogenin A can inhibit ferroptosis to prevent and treat cerebral ischemia reperfusion injury for the first time, including greatly reducing the volume of cerebral infarction caused by cerebral ischemia reperfusion; the invention provides a plant-derived natural medicine for treating cerebral ischemia reperfusion injury, which has great application potential, and can be used for remarkably improving neurological function injury symptoms such as autonomous activity reduction, sensory motor function damage and motor coordination reduction caused by cerebral ischemia reperfusion, and the invention provides a plant-derived natural medicine for treating cerebral ischemia reperfusion injury.

This application belongs to the field of traditional Chinese medicine technology and relates to a traditional Chinese medicine composition for treating cerebral infarction. The traditional Chinese medicine composition of this application comprises the following raw materials in parts by weight: Ligusticum chuanxiong, Astragalus membranaceus, Pueraria lobata, Uncaria rhynchophylla, and a compound fungus; the traditional Chinese medicine composition is prepared by the following method: S1, Ligusticum chuanxiong, Astragalus membranaceus, Pueraria lobata, and Uncaria rhynchophylla are pulverized and the active ingredients are extracted by water extraction and alcohol precipitation to obtain an extract; S2, the compound fungus is pulverized, extracted by boiling with deionized water at normal pressure, and then fermented with fermenting bacteria in a sealed container to obtain a fermentation liquid; S3, the extract and fermentation liquid are combined, concentrated under reduced pressure, and spray-dried to obtain the traditional Chinese medicine composition. This application has a simple formula and safe ingredients. Through multiple effects such as promoting blood circulation and removing blood stasis, tonifying qi and strengthening the exterior, clearing heat and detoxifying, dilating blood vessels, and calming the liver and extinguishing wind, it jointly promotes cerebral blood circulation, reduces brain tissue damage, and promotes nerve cell repair and regeneration, showing broad clinical application prospects.