291 results about "Cerebral infarction" patented technology

The invention relates to the technical field of medical auxiliary evaluation and human-computer interaction, in particular to a cognitive level evaluation system and method applied to a caregiver of a cerebral infarction patient. Generating task parameter data based on the multi-modal feature data through a task generation module; the cognitive state decoding module decodes a comprehensive cognitive state by using a double-flow deep learning network to generate a cognitive load, an attention trend and a task response score; the feedback optimization module predicts the change trend of the cognitive ability in combination with a dynamic Bayesian network, and dynamically adjusts task parameters through a closed-loop feedback mechanism; according to the method, the dynamic adaptation of the evaluation task and the design of the intervention task are realized, and the accuracy, interestingness and applicability of evaluation are effectively improved.

The invention provides a medicine for preventing and treating cerebral arterial thrombosis, and belongs to the technical field of neuromedicine. The medicine comprises salmon polypeptide as shown in SEQ ID NO.1 and a pharmaceutically acceptable carrier, and experimental results show that the salmon polypeptide has good safety, can effectively improve oxygen-glucose deprivation / reoxygenation injury of brain cells, and remarkably reduces neurological impairment and cerebral infarction of mice suffering from cerebral arterial thrombosis. The invention also discloses a pharmaceutical composition for treating cerebral arterial thrombosis. The pharmaceutical composition comprises the salmon polypeptide and edaravone. The composition shows a remarkable synergistic effect, compared with the single use of the salmon polypeptide or edaravone, the composition can more remarkably reduce neurological impairment and cerebral infarction, and the actual effect is obviously superior to the theoretical superposition effect. Therefore, the invention provides a novel and more effective treatment scheme for the treatment of cerebral arterial thrombosis.

The invention discloses a brain health monitoring and cerebral infarction early warning method and system for old people. The method comprises the steps that electroencephalogram, electrocardio, blood oxygen and cerebral blood flow velocity multi-mode physiological signal data are collected; adopting a characteristic mode decomposition method to decompose the multi-mode physiological signal data; the method comprises the following steps: introducing a KAN network into an MATE structure, carrying out nonlinear mapping and feature reconstruction, and constructing a KAMATE model; an improved Bayesian optimization algorithm is obtained based on the Bayesian optimization algorithm in combination with a dynamic balance strategy; the improved Bayesian optimization algorithm is combined with the characteristic mode decomposition method to achieve characteristic decomposition of the multi-mode physiological signals, and parameters of the KAMATE model are optimized; dividing the brain health state into four grades according to a prediction result output by the KAMATE model; according to the invention, real-time early warning of abnormal cerebral blood supply, cognitive decline and cerebral infarction high-risk states of the elderly can be realized, intelligent support is provided for health management of the elderly, and the method has important application value.

The invention relates to the technical field of pressure sore nursing, discloses an intelligent nursing system for pressure sore nursing of a patient suffering from cerebral infarction and a back raising optimization method, and is particularly used for solving the problem that the risk of pressure sore deterioration is caused due to the fact that the patient suffering from cerebral infarction cannot sense local pressure and abnormal shearing force in the back raising process in time due to feeling and dyskinesia. The system comprises a data acquisition module, a feature extraction module, a feature fusion module, a feature dimension reduction module, a pressure sore risk prediction module, a feedback control module and a back-up execution module, and the method is based on a target function, and dynamically adjusts back-up execution parameters in combination with acquired data and pressure sore risk scores and grades obtained through analysis. According to the method, multi-modal data are collected in real time, the body posture, motion trail, local stress, shearing force and pressure of the patient in the back raising process are comprehensively considered, closed-loop control is optimized through an objective function, the back raising speed, angle and supporting force are dynamically adjusted, and pressure sore aggravation or secondary injury of the patient after cerebral infarction in the back raising process is prevented.

The invention provides a bifunctional nano-enzyme SERS (Surface Enhanced Raman Scattering) detection platform for ultrasensitively detecting mi RNA (Ribonucleic Acid) related to cerebral infarction and a preparation method, and relates to the technical field of biomedical engineering. The preparation method comprises the following steps: synthesizing gold nanorods (AuNRs) by using a seed growth method, and growing Pt on the surface of a product to prepare gold platinum nanorods (Au (at) Pt NRs); the preparation method comprises the following steps: synthesizing gold nano hexagonal plates (AuNHs) by using a seed growth method, and preparing an AuNHs array through oil-water interface self-assembly; and modifying an aptamer complementary chain (H1) on the Au (at) Pt NRs obtained in the step (1) through an Au-S bond. And combining the assembled AuNHs array with a nucleic acid aptamer (cDNA) corresponding to mi R-106a-5p to functionalize the assembled AuNHs array in the step (2), so as to construct an SERS (Surface Enhanced Raman Scattering) detection platform. The target mi R-106a-5p can be specifically combined with cDNA, so that Au (at) Pt NRs carrying H1 are separated from the surface of an AuNHs array, TMB oxidation is reduced, and SERS signals are remarkably reduced. And according to SERS signal intensity, substituting the SERS signal intensity into a linear regression equation to realize quantitative detection of mi RNA.

The invention belongs to the field of medicines, and discloses application of a stress-induced stem cell extract in treatment of cerebral apoplexy. The inventor finds that stem cells are cultured under proper stress conditions through screening, and the separated stem cell extract (also known as Alritoin) can increase the axon length and dendritic length of normal primary neurons and is beneficial to growth and conduction of nerve fibers; in a pdMCAO model, the volume of cerebral infarction in the acute stage of ischemia of a mouse can be remarkably reduced, the neurological function score can be improved, and a relatively good improvement trend is achieved in the aspect of cognition; in the acute stage of cerebral ischemia reperfusion, the pharmaceutical composition has remarkable effects on reducing the cerebral infarction volume of a mouse, reducing relative edema and improving the neurological function, and is relatively long in medication time window; in a cerebral ischemia reperfusion model, the trend of improving local cerebral blood flow is shown. The allitoin is expected to be developed into a promising drug for cerebral apoplexy, especially a drug for treating ischemic cerebral apoplexy.

The invention provides a culture method, application and detection method of mesenchymal stem cells for treating nervous system diseases, and belongs to the technical field of biological medicines. The invention provides a culture medium of mesenchymal stem cells, a method for culturing and subculturing the mesenchymal stem cells by using the culture medium, and a method for detecting the biological efficacy of the mesenchymal stem cells for treating nervous system diseases. The mesenchymal stem cell preparation disclosed by the invention has a relatively good treatment effect on nervous system diseases, and can be used for improving the new object recognition capability and the cerebral infarction range, inhibiting the release of inflammatory factors, reducing the oxidative stress level and narrowing the spinal cord lesion range so as to improve nervous system injury.

The invention relates to an electrocoagulation guide wire and an electrocoagulation guide wire system. The electrocoagulation guide wire comprises a core wire body, a sheath and a coating, the core wire body is sleeved with the sheath, the coating is arranged on the sheath and part of the core wire body, the core wire body comprises a far-end section and a near-end section which are connected with each other from the far end to the near end, the far end of the far-end section is further provided with an electrocoagulation area, and the electrocoagulation area is arranged between the far-end section and the near-end section. The electrocoagulation guide wire is characterized in that the sheath and the coating are not arranged in the electrocoagulation area, under a 500V voltage test, the insulation resistance of the coating of the electrocoagulation guide wire or any point on the sheath which is not covered by the coating is not less than 10megohm, and the direct-current resistance of the electrocoagulation guide wire is less than 20ohm. According to the electrocoagulation guide wire, thrombus escape caused by thrombus formed by electrocoagulation outside aneurysm can be avoided, the risk of postoperative cerebral infarction is reduced, the operation safety is improved, and damage to materials of the electrocoagulation guide wire in the electrocoagulation process can be avoided.

The invention discloses a nasal delivery multistage targeting bionic nano drug delivery system as well as a preparation method and application of the nasal delivery multistage targeting bionic nano drug delivery system. According to the drug delivery system, a black phosphorus nanosheet with an active oxygen scavenging effect is used as an inner core carrier, a neuroprotective agent fingolimod hydrochloride FTY720 and polydimethyldiguanide PolyMet are loaded, and a microcolloid cell membrane and a mitochondrial membrane are modified on the surface of the preparation; the nano drug delivery system is applied to treatment of cerebral arterial thrombosis reperfusion injury, can overcome the blood brain barrier, can quickly enter the brain through nasal administration, realizes efficient delivery of drugs, remarkably reduces the cerebral infarction area, reduces the brain inflammation level, protects nerve cells, greatly relieves cerebral arterial thrombosis reperfusion injury, and has application prospects.

The invention discloses application of (20S)-ginsenoside Rh1 in preparation of drugs for preventing and / or improving cerebral arterial thrombosis, and relates to the technical field of medical application of natural drugs. The invention verifies that (20S)-ginsenoside Rh1 up-regulates the expression of an anti-apoptosis gene by promoting STAT3 phosphorylation and translocation to a cell nucleus, so that the (20S)-ginsenoside Rh1 plays a role in protecting neuronal injury induced by sugar oxygen deprivation. In MCAO model mice, the (20S)-ginsenoside Rh1 obviously relieves the symptom of ischemic cerebral apoplexy and has positive influence on neurodegenerative events related to cerebral infarction, and the anti-apoptosis and neuroprotection effects are most prominent. Mechanism research shows that (20S)-ginsenoside Rh1 plays a therapeutic role in PC12 cell and MCAO model mice by activating a JAK2 / STAT3 signal channel.

The invention discloses a cerebral infarction swallowing dysfunction risk prediction method based on machine learning, and belongs to the technical field of risk prediction, and the method comprises the following steps: S1, retrieving and collecting a plurality of data sets related to cerebral infarction from an MIMIC IV database; s2, original data in the data set are preprocessed, clinical information is strictly verified, and data which does not conform to research standards are removed; s3, predicting the processed data through a plurality of models, and finding out the model with the best performance; and S4, continuously training the optimal model, constructing a swallowing function risk prediction model of the optimal model, deploying the optimal model to a webpage based on a Streamline framework, predicting the swallowing disorder risk of the patient, and generating a personalized SHAP force field graph. According to the method, a plurality of machine learning models are constructed, the model with the optimal performance is selected, and the cerebral infarction dysphagia risk is accurately predicted in combination with clinical data.

The present invention relates to a method for making a non-human primate model of cerebral infarction comprising a step of administering endothelin to the brain basal nucleus-thalamic region of a non-human primate, thereby inducing brain basal nucleus disorders, thalamic disorders and endocystic disorders, and a method for treating subacute stages-containing NeuroD1 protein or a polynucleotide encoding a NeuroD1 protein The pharmaceutical composition can be used for treating chronic cerebral infarction, transbronchial infarction or cerebral infarction with brain disorder in a transbronchial dominating region.

The invention relates to an accurate evaluation and dynamic optimization system for cerebral infarction ultra-early reperfusion treatment, in particular to the field of biomedicine.Heterogeneous image data are fused through multi-center federal learning, and a high-robustness standardized brain characteristic spectrum is constructed; the real-time physiological parameters are utilized to drive the dynamic graph network, and the pathological process of the ischemic penumbra evolved along with time is accurately simulated; a core infarction zone and half-dark band probability graph with reasonable spatial distribution is generated by introducing a multi-task classifier with mutual exclusion constraints; and finally, a virtual contrast perfusion image is generated in combination with the individual blood vessel conditions of the patient to perform personalized calibration, so that the accuracy and individualization level of the delineation of the penumbra are remarkably improved, more reliable and dynamic decision support is provided for a clinician to formulate an ultra-early reperfusion treatment scheme, and the risk of insufficient treatment or excessive treatment is effectively avoided.

The invention relates to the technical field of medical equipment, in particular to an intermittent high-oxygen system. The intermittent hyperoxia system provided by the invention can monitor the oxygen concentration, temperature, humidity, pressure and other environmental parameters in the hyperoxia cabin in real time, has alarm and automatic correction functions, can ensure the safety in the hyperoxia treatment process, and avoids the harm to a testee due to the fact that the parameters exceed a set range. The intermittent hyperoxia system can be used for intermittent hyperoxia intervention in the acute stage of ischemic brain injury and other types of brain injury, can effectively improve the neurological function and reduce the cerebral infarction volume, and has important application value and market prospect.

The invention relates to the technical field of exosome preparations, and particularly discloses an exosome nasal delivery preparation as well as a preparation method and application thereof. The preparation comprises the following components: 1 * 10 < 9 >-5 * 10 < 11 > particle number / ml of exosome, 1%-4% w / v of a saccharide protective agent, 0.5%-4.5% w / v of an alcohol protective agent, 0.05%-1% w / v of an absorption enhancer and a solvent. The exosome nasal delivery preparation can break through the blood brain barrier and quickly take effect, and the intracerebral delivery efficiency of the exosome nasal delivery preparation can be improved by 2-5 times compared with intravenous injection. The nasal administration preparation can be used for treating central nervous system diseases such as cerebral apoplexy and the like, and can remarkably improve the neurological function, reduce the cerebral infarction area and promote functional recovery.

The invention provides an application of combination of indobufen and butylphthalide in preparation of a drug for preventing and / or treating cerebrovascular diseases, indobufen and butylphthalide are combined for use, have a synergistic effect, remarkably improve the treatment effect, can be used for preparing the drug for preventing, secondarily preventing or treating the cerebrovascular diseases, and has a wide application prospect. The medicine is especially suitable for treating cerebral apoplexy and transient ischemic attack, and can be used for prophylactically improving cerebral infarction caused by cerebral arterial thrombosis.

A Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction having neuroglobin (Ngb) activation and neuroprotective effects and, on the basis thereof, a neuroprotective composition containing, as an active ingredient, a Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction. The neuroprotective composition can be used, through the activation of neuroglobin (Ngb), as a pharmaceutical composition or a food composition for treatment, alleviation and prevention of a stroke, a cerebral infarction, thrombosis, cerebral degenerative disease, vascular dementia, memory loss, short-term memory impairment, a concentration disorder, anxiety, nervousness and the like, and for brain damage protection, brain function improvement and cranial nerve cell protection.

The invention relates to the technical field of animal experiments, and discloses a mouse cerebral infarction model establishment method and system.The mouse cerebral infarction model establishment method comprises the following steps that in the mouse cerebral infarction model operation process, mouse operation data are obtained in real time, and anomaly detection feedback is carried out, specifically, the anomaly detection feedback comprises generation of a suture insertion anomaly signal; if the suture insertion abnormal signal is generated, performing similarity analysis of curve shapes and characteristics in combination with a historical database of the mouse cerebral infarction model surgery, and constructing a significant similar curve set; and analyzing the effectiveness of the mouse cerebral infarction model operation in the significant similar curve set, and determining the adjustability of the current mouse cerebral infarction operation abnormality. According to the method, the pressure and depth data are collected in real time, the anomaly detection coefficient is calculated, immediate early warning of the suture insertion anomaly is carried out, whether adjustment is needed or an operation is ended is analyzed after early warning, the subjectivity of traditional experience judgment is reduced, and the success rate of the operation is increased.

The invention discloses application of selazinomethyl ether and a pharmaceutical composition thereof in preparation of a medicine for preventing or treating brain injury. The invention provides the application of selazine methyl ether in preparing the medicine for preventing or treating the brain injury for the first time, and selazine methyl ether has a remarkable effect in preventing or treating the brain injury, especially cerebral arterial thrombosis and the brain injury caused by hemorrhagic transformation of the cerebral arterial thrombosis. And cerebral injury caused by cerebral arterial thrombosis and hemorrhagic transformation can be obviously relieved. According to the application disclosed by the invention, the sefoazinomethyl ether has the effects of remarkably reducing the cerebral infarction area and behavioral scoring under the condition of middle cerebral artery occlusion; the selobezine methyl ether has the effects of remarkably reducing the hemorrhage area, hemorrhage score and behavioral score under acute high glucose and middle cerebral artery occlusion; the pharmaceutical composition containing selazine methyl ether can become a novel drug for preventing or treating brain injury, and can be used for treating various cerebrovascular diseases including cerebral arterial thrombosis and hemorrhagic transformation of cerebral arterial thrombosis.

The invention discloses a family member participation type vascular intervention diagnosis and treatment postoperative cerebral infarction early warning method. The method comprises the following steps that patient data are acquired through a client module based on wrist strap data of a patient, and a cerebral infarction monitoring module is started; based on the patient data, binding the patient data with a client module through living body detection and information authentication of a cerebral infarction monitoring module, and starting a monitoring process of the cerebral infarction monitoring module; the behavior data and cerebral infarction risk level data of the patient are obtained through the monitoring process, and the monitoring process is a periodic task and is started and executed at fixed time in 1 hour, 3 hours, 6 hours, 12 hours and 24 hours after the operation; and acquiring early warning data through a medical care response module based on the patient behavior data and the patient cerebral infarction risk level data, wherein the early warning data is used for providing a postoperative cerebral infarction intervention voucher for the patient by medical staff.

This invention discloses a data processing method and system based on the changing trends of image features, relating to the field of cerebral infarction early warning technology. The data processing method includes: feature extraction: processing image data and modal data separately using feature analysis methods to obtain image features, image feature change data, modal data features, modal data feature change data, and the regions where the features are located. In this invention, image data provides intuitive information about brain structure and lesions, while modal data supplements key features such as hemodynamics, brain tissue electrical activity, and electrical impedance from different physiological dimensions. TCD data can monitor blood flow velocity and vascular resistance in real time, BI data is sensitive to changes in pathological states such as cerebral edema, and EEG data reflects subtle changes in neuronal electrical activity. Through feature extraction and analysis, the combination of multi-source heterogeneous data achieves the correction of image feature changing trends, thereby ensuring the accuracy of data processing.

The invention belongs to the technical field of medical treatment, and discloses application of dehydroequol to treatment of neonatal hypoxic ischemic encephalopathy. The dehydroequol is used for treating the neonatal hypoxic-ischemic encephalopathy, and it is proved that the dehydroequol can reduce the area of cerebral infarction induced by hypoxia and ischemia, relieve encephaledema and inhibit oxidative stress and copper death, and has a treatment effect on neonatal hypoxic-ischemic brain injury. Dehydroequol is a medicine for treating hypoxic ischemic encephalopathy of newborns and has a development prospect.

The invention discloses a medicine formula for preventing cerebral infarction and promoting rehabilitation and a preparation method thereof, and belongs to the technical field of preparation of medicines for preventing cerebral infarction, the medicine formula comprises the following raw materials by weight: 10-15 parts of flatstem milkvetch seed, 10-15 parts of dodder, 10-15 parts of tortoise plastron, 10-12 parts of red peony root, 6-9 parts of safflower, and 15-30 parts of red sage root. According to the invention, the flatstem milkvetch seed, the semen cuscutae and the tortoise plastron are used for nourishing liver and kidney, replenishing essence and benefiting marrow, so that the traditional Chinese medicine theory that kidney dominates bone marrow generation and brain is marrow sea is met, and brain function decline is improved from the source; meanwhile, the radix salviae miltiorrhizae, the radix paeoniae rubra and the flos carthami have the effects of promoting blood circulation to remove blood stasis, activating meridians to stop pain, effectively improving brain microcirculation, inhibiting platelet aggregation and reducing blood viscosity, and supplement each other to achieve the effects of strengthening the body resistance to eliminate pathogenic factors and treating both symptoms and root causes, so that the traditional Chinese medicine composition can be used for preventing cerebral infarction of high-risk groups and is also suitable for functional recovery in the rehabilitation period after cerebral infarction.

The invention discloses a Wulian Yijintong for relieving ischemic stroke. The Wulian Yijintong comprises euonymus fortunei, polygala fallax hemsl, caulis spatholobi, tinospora sinensis merr, giantleaf ardisia rhizome, beautiful millettia root, radix fici simplicissimae and pseudo-ginseng. Compared with the prior art, according to etiological analysis and treatment mechanism of ischemic stroke based on the Zhuang medicine theory, tinospora sinensis merr for dispelling wind, polygala fallax hemsl for reinforcing qi and nourishing blood, and caulis spatholobi for promoting blood circulation and enriching blood are combined as main drugs to jointly achieve the effects of dispelling wind and removing toxicity, regulating qi activity, promoting synchronization of three qi and dredging two paths and three paths through airborne blood circulation; the content of ferrous ions in blood and the water content of the brain are reduced, the content of glutathione is increased, and the cerebral infarction rate is reduced.

The invention relates to an endocavitary interventional operation device which comprises a first sheath assembly, a second sheath assembly and an umbrella protection assembly, the first sheath assembly comprises a protection umbrella and a first sheath tube, and the protection umbrella is connected to the far end of the first sheath tube; the umbrella protection assembly is detachably connected to the near end of the second sheath assembly, the first sheath tube can axially and movably penetrate through the umbrella protection assembly and can drive the protection umbrella to retract into the umbrella protection assembly, and when the umbrella protection assembly is connected with the near end of the second sheath assembly, the first sheath tube can push the protection umbrella from the umbrella protection assembly to the second sheath assembly. According to the endocavitary interventional operation device, the umbrella protection assembly is used for guiding the protection umbrella to smoothly enter the second sheath tube from the near end of the second sheath assembly, operation convenience and safety are provided, thrombus and plaques in a blood vessel are captured in the whole process through the protection umbrella, and the cerebral infarction occurrence rate is reduced.

To provide a composition for preventing, ameliorating, or treating a disease caused by nitration of tyrosine in proteins comprising tyrosine as an effective component.SOLUTION: Tyrosine as an effective component of the present invention not only can enhance the activity of GS having reduced activity and but also has an effect of restoring the amount (i.e., ratio) of glutamine and glutamic acid in brain and the amount of ammonia to normal level, an effect of enhancing the insulin sensitivity in a model of type 2 diabetes, an effect of suppressing the excitotoxicity and oxidative stress in a model of epileptic seizure, an effect of reducing cerebral infarction and enhancing the activity of GS in a model of brain stroke, an effect of eliminating the nitration of tyrosine using human recombinant MnSOD, and an effect for acute renal failure and hyperammonemia. Therefore, the tyrosine as an effective component of the present invention can be efficiently used as a functional health food composition for preventing or ameliorating a disease caused by nitration of tyrosine in proteins or a pharmaceutical composition for preventing or treating a disease caused by nitration of tyrosine in proteins.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of biological medicine. More specifically, the invention provides the annular RNACircMAP2, and the sequence of the annular RNACircMAP2 is as shown in SEQ ID NO. 1 or SEQ ID NO. 2. The invention proves that CircMAP2 can be used as a novel biomarker for diagnosing acute ischemic stroke for the first time. Compared with a traditional imaging diagnosis method, the acute ischemic stroke can be diagnosed by detecting the expression level of the CircMAP2 in the plasma and the plasma exosome of the patient, the cerebral infarction area of the acute ischemic stroke can be speculated through the expression level of the CircMAP2, and the method has the advantages of being easy and convenient to operate, high in detection speed and low in cost; the system is especially suitable for popularization and use in primary medical institutions. The product for diagnosing acute ischemic stroke provided by the invention can quickly and accurately diagnose acute ischemic stroke, and has good clinical popularization prospect and application value.

The invention provides a medicine for improving neurological dysfunction after cerebral ischemia, and relates to the technical field of biological medicine and molecular biology, and the medicine comprises the following steps: S1, preparing materials; s2, cell injury model and intervention test; s3, cell activity and oxidative stress index detection. The invention provides application of combination of baicalein and ferulic acid in preparation of a medicine for improving neurological dysfunction after cerebral ischemia, the embodiment of the invention proves that combination of baicalein and ferulic acid can improve neurological dysfunction after cerebral ischemia by reducing cerebral infarction area, resisting oxidation, inhibiting inflammatory response and the like, and test data shows that compared with a model group, the combination of baicalein and ferulic acid has the advantages that the combination of baicalein and ferulic acid has a good application prospect. White cerebral infarction areas of the rats in the administration group are reduced; after the palmitic acid treatment, the baicalein and ferulic acid combined administration group can promote the proliferation of SH-SY5Y nerve cells; after baicalein and ferulic acid are combined for treatment, the MDA level in damaged cells is remarkably reduced, and the SOD and GSH levels are remarkably increased, so that the baicalein and ferulic acid have the effects of resisting oxidation, inhibiting inflammation and protecting nerve cells.

The invention provides a traditional Chinese medicine preparation for cerebral arterial thrombosis, and belongs to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine preparation is prepared from gentiana macrophylla, divaricate saposhnikovia root, mulberry leaf, radix scrophulariae, ruddle, bulbus fritillariae cirrhosae, bamboo juice, selfheal, poria with hostwood and szechwan chinaberry fruit, and the whole formula has the effects of calming liver and suppressing yang, calming endogenous wind and relieving convulsion, eliminating phlegm and inducing resuscitation. The traditional Chinese medicine preparation has a remarkable improvement effect on the neurological function of a cerebral ischemia reperfusion injury model rat, can effectively reduce the water content of the brain tissue of the rat and the cerebral infarction volume, remarkably improves the levels of GSH and SOD in the brain tissue of the rat, reduces the MDA level, and has the effect of improving oxidative stress induced by cerebral ischemia reperfusion. The traditional Chinese medicine preparation can effectively relieve neurological function loss of a patient suffering from cerebral arterial thrombosis, help to recover life functions of the patient and relieve clinical symptoms of the patient, is definite and remarkable in curative effect and can be used as a new medicine for treating cerebral arterial thrombosis.

The invention relates to a ligand targeting neutrophil and neurons as well as a preparation method and application of the ligand. The ligand for targeting the neutrophil and the neuron is prepared from the following raw materials in parts by weight: 30 to 50 parts of DSPE-PEG-Tet1, 2 to 3 parts of ketal thiol with carboxyl groups at two ends and 30 to 50 parts of a neutrophil targeting ligand, the neutrophil targeting ligand is one or more of sialic acid, an anti-CD66b antibody, an anti-CD177 antibody, an anti-CD16b antibody, N-formylmethionine peptide (fMLF) and an analogue thereof, a CXCR1 / CXCR2 binding peptide, an integrin binding peptide, a selectin ligand and lectin. According to the invention, sequential targeting of neutrophile granulocytes-neurons can be realized, target cells of ischemic lesions can be accurately protected, and the improvement effect on the cerebral infarction area of MCAO rats can be obviously enhanced.