Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
50results about How to "Expansion of medical use" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Use of naringenin and derivative in preparation of product for resisting cardiovascular and cerebrovascular disease
InactiveCN1864675AExpansion of medical useEnhance pharmacological effectsOrganic active ingredientsNervous disorderDiseaseReperfusion injury
The present invention relates to the new use of narigenin and similar compounds in preparing medicines for treating cardiac and cerebral vascular diseases. These compounds include narigenin and its derivative, hesperidene and its derivative, isosakuranetin and its derivative, eriodictyol and its derivative, etc. These compounds may be used in preventing, diagnosing and treating cerebral infarction, myocardial infarction, cerebral ischemia-reperfusion injury, myocardial ischemia-reperfusion injury and other cardiac and cerebral vascular diseases as well as Alzheimer disease and its relevant diseases. These compounds have high pharmacological action, low toxicity, wide material source, low cost and other advantages.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Use of vanillin receptor agonist in preparation of product for resisting Alzheimer disease
InactiveCN1736485ATechnical expertiseEnhance pharmacological effectsNervous disorderHeterocyclic compound active ingredientsCapsaicinAlzheimer's disease
Owner:SHANGHAI MEDICILON INC
Use of polygonin for preparing product for resisting dementia
InactiveCN101411716AEnhance pharmacological effectsRich sourcesOrganic active ingredientsNervous disorderClinical therapyLearning memory
The invention relates to application of polydatin which is an extract of polygonum cuspidatum. In-vitro researching experiments show that the polydatin has strong protecting effect for pathological injuries caused by rats multiple infarctional cerebral ischemic injuries, can significantly improve learning memory function of dementia model rats, so the polydatin can be used for preparing a product for resisting vascular dementia and a product, particularly a medicine for resisting senile dementia. The modes for using the polydatin include independent use, or combined use with other chemical substances. Dementia is a key disease impacting health of the elderly, particularly, frequency of disease development of the vascular dementia and the senile dementia is significantly increased to seriously threaten health and life of human beings. The invention provides a novel drug source for clinically treating the vascular dementia and the senile dementia, and has important value for developing and utilizing medicinal plant resource in China.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Use of extraced total timosaponin for producing myocardial ischemia treating products
InactiveCN1682873AEnhance pharmacological effectsRich sourcesUnknown materialsCardiovascular disorderVascular diseaseMedicine
The present invention relates to the new use of total timosaponin as one Chinese medicine extract. The extract has timosaponin B-II compound as main component in the content of 30-70 % and is obtained through conventional extraction, separation and purification process. The extract has powerful pharmaceutical effect of diagnosing and treating myocardial ischemia and relevant diseases. It has simple preparation process, high yield, stable chemical property and safety and use wide application range.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Composition for resisting ischemia reperfusion injury and preparation method and application thereof
InactiveCN102580099APracticalSimple preparation processDigestive systemEster active ingredientsSocial benefitsSide effect
The invention relates to a medicinal composition for treating an ischemia reperfusion injury, particularly a hepatic ischemia reperfusion injury, and a preparation method and application thereof. The composition comprises an M-cholinergic receptor blocker and a cholinesterase inhibitor, has a simple and convenient preparation process, is safe to use, has an obvious curative effect, can be used for obviously improving the cell apoptosis caused by the ischemia reperfusion injury and overcomes the side effects caused by existing common medicaments. The invention expands novel medical application of an existing muscarinic receptor blocker and also provides a novel medicine intervention means for preventing and treating the ischemia reperfusion injury. The medicinal composition is suitable for large-scale production and commercial application in the industries of medicine, reagents and the like, has excellent application prospect and has obvious social benefits and economic benefits.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Brefeldin A-producing bacteria and method for preparing brefeldin A by fermentation
The invention relates to Brefeldin A-producing bacteria, a preparation method, a method for preparing the brefeldin A by fermentation and the application thereof. The Brefeldin A-producing bacteria has the advantages of easy selection, cultivation and storage, low cost, simple process, short preparation period, high yield, no usage of toxic raw material, less organic solvent, thorough guarantee of medicine resource, potential of mass production and favorable economic and social benefits, contributes to the maintenance of ecological balance and the protection of natural resources. The fermentation product of the invention, of which the main component is THSG, develops novel medical application, the Brefeldin A has high safety, low toxicity, stable property, stronger pharmacological action, simple preparation process, high yield and considerably wide range of application, is multipurpose, and can provide a novel source for medicines for preventing, diagnosing, detecting, protecting, curing and researching antimycotic, antiviral and antineoplastic diseases and the directly related diseases.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Application of oligomeric proantho cyanidins in preparing products resisting vascular dementia
InactiveCN101530410AEasy to solveGood treatment effectOrganic active ingredientsNervous disorderLipid peroxidationCyanidin
The invention relates to application of oligomeric proantho cyanidins in preparing products for preventing, diagnosing, detecting, protecting, treating and studying vascular dementia and directly related diseases thereof, in particular to new application in medicament and health-care products. Experiments prove that oligomeric proantho cyanidins can improve the study memory ability of a heart and brain ischemia-reperfusion mouse and a permanent bilateral common carotid arteries rat, inhibit lipid peroxidation in brains of the heart and brain ischemia-reperfusion mouse and the permanent bilateral common carotid arteries rat, and improve the superoxide dismutase enzyme activity of the heart and brain ischemia-reperfusion mouse and the permanent bilateral common carotid arteries rat. The oligomeric proantho cyanidins have strong action, clear effect, rich resource, simple preparation process, high yield, stable property and safe use, in particular one object with multiple functions and wide application range, and can play roles furthest. Disease rate of dementia rises gradually, after popularization, the application of oligomeric proantho cyanidins can generate significant social benefit and economic benefit in short time.
Owner:ZHEJIANG XIAOSHAN HOSPITAL
Use of giant knotweed rhizome extract in preparing product for resisting AIDS virus and hepatitis B
InactiveCN101214285ATechnical expertiseEnhance pharmacological effectsOrganic active ingredientsSugar derivativesViral infectious diseaseHepatitis B virus
The present invention relates to purposes of giant knotweed extract. The in vitro anti-HIV experiment shows that resveratrol 3-O-Beta-D- glucoside 2íÕ-sulfate sodium or potash salt and resveratrol 3-O-Beta-D- glucoside 4íÕ-sulfate sodium or potash salt show significant activity of resisting hepatitis B virus; resveratrol 3-O-Beta-D- glucoside 2íÕ-sulfate sodium or potash salt also has significant HIV inhibited effect. The virus infectious diseases such as AIDS and hepatitis B poses a serious threat to human's health and life and hepatitis B is one of the major diseases affecting human's health. The present invention provides a lead compound for doing R&D of novel anti-HIV and hepatitis B virus medicines and also a novel medicine source for clinic application, thus having a significant value to develop and utilize the medical plant resources of our country.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Patrinias cabra aglycon extraction and its preparation method and anti colon cancer application
InactiveCN101057876AWide variety of sourcesCheap sourceAntineoplastic agentsPlant ingredientsMedicineAglycone
The invention relates to a medicine treating carcinoma of colon and the method for preparing the same, which in detail is aglycone extract from root of Patrinia scabra Bge and the preparation method. The effective component is iridoid glycosides aglycone, the content is above 40%. The invention also provides the medicine agent and preparation. It is proved by pharmacologia test that the medicine is characterized by safe utilization, function of preventing the weight of tumor in transplanted carcinoma of colon. The extract can be produced into preparations of tablet, capsule, drop pill, granular or oral.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Novel use of pentapeptide and metabolite thereof in preparation of anti-dementia product
ActiveCN103191407AEasy to solveGood treatment effectNervous disorderDipeptide ingredientsMetaboliteSmall peptide
The invention relates to the technical field of biological medicines and in particular relates to a novel use of pentapeptide and metabolite thereof in preparation of an anti-dementia product. Amino acid sequences of the small peptide are as shown in Seq No.1, No.2, No.3, No.4, No.5 and No.6. According to the pharmacological experiment of the alzheimer disease and vascular dementia animal model, the small peptide and the metabolite thereof can be used for remarkably improving the cognitive function of the dementia, so that the small peptide and the metabolite thereof have the effects of preventing the alzheimer disease and vascular dementia, and therefore, the pentapeptide and metabolite thereof can be used for preparing the medicine for preventing senile dementia including the alzheimer disease and vascular dementia.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
Melamine antigen, related antibody and preparation method thereof
InactiveCN102702345ASynthetic properties and stable structureGood synthesis reproducibilityOvalbuminSerum albuminAntigenMonoclonal antibody
The invention relates to a melamine antigen, a related antibody and a preparation method thereof. Melamine and carrier protein are coupled by using PAD (polyaldehyde dextran) as bridge reagent; coupling products is used to immunize animals to prepare monoclonal antibodies for detecting melamine. Artificially-prepared melamine antigen and related antibody provided by the invention can be used for researching and developing melamine immunity detection reagents to meet detection demand on low cost, rapidity and convenient operations.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Function of anemarrhena extract for preparing medicine of treating prostatic hyperplasia
InactiveCN101062250AEnhance pharmacological effectsLow priceUrinary disorderPlant ingredientsAdditive ingredientChemical constituents
The invention discloses an application of compound of timosaponin extract in foods and preparation of prostate hyperplasia medicine in medicine and pharmacology technical domain, which is characterized by the following: possessing saponin and chromocor chemical element in timosaponin; possessing anti-diabetes medicinal and antibiotic function; setting the sum of mango glycosides and new mango glycosides content not less than 50%. This invention also discloses a basic preparing method. This invention can be used to cure big mouse prostate hyperplasia of enarmon, which can prepare medicine to prevent and cure prostate hyperplasia.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Application of anthocyanin in preparation of drugs for treating cell injury caused by arsanilic acid
ActiveCN108272793AApoptosis antagonismExpansion of medical useOrganic active ingredientsAntinoxious agentsMicrogramDrug
The invention discloses application of anthocyanin in preparation of drugs for treating cell injury caused by arsanilic acid. An in-vitro chick embryo fibroblast DF-1 cell model is established for studying application of arsanilic acid and anthocyanin in apoptosis of DF-1 cells. The application of arsanilic acid and the anthocyanin in apoptosis of the DF-1 cells firstly discovers that arsanilic acid has cytotoxicity on the DF-1 cells and is capable of inducing the apoptosis. The anthocyanin with a certain concentration being 50-100 micrograms per milliliter can resist the apoptosis caused by arsanilic acid; the medical application of the anthocyanin is expanded; the development of drugs taking the anthocyanin as an effective component and having new indications can be facilitated.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Target protein for improving spermatogensis
InactiveCN103285377AImprove spermatogenesisPracticalPeptide/protein ingredientsSexual disorderProtein targetPlant Germ Cells
The invention relates to a target protein which takes a betaB2 crystal protein to improve the spermatogensis and a novel application thereof. A betaB2 crystal protein knockout mouse model is used for analyzing the expression of the betaB2 crystal protein in mouse testis tissues to confirm the reduction of CaMKIV expression and activity, caused by betaB2 crystal protein knockout, so as to reduce a reproductive function; and a CaMKIV expression level is reduced so that the expression of Bcl-2 is reduced to enable testis germ cells to be excessively proliferated and apoptotic and damage sperms. Therefore, the target protein for improving the spermatogensis is the betaB2 crystal protein, and a novel medicine resource and a novel application preparation are provided; and the target protein has the very important value for improving the existing medical level. The target protein disclosed by the invention is safe and cheap, effective in treatment and stable in property, is suitable for large-scale production and business application of industries of medicines, reagents and the like, is easy to popularize and apply, has a very good application prospect, and has obvious social benefits and economic benefits.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Application of 4-hydroxyl-2-pyridone alkaloid in preparing antitumor product
ActiveCN107536833AStrong activationEasy to prepareOrganic active ingredientsOrganic chemistryDiseaseChemical structure
The invention discloses application of 4-hydroxyl-2-pyridone alkaloid in preparing an antitumor product. The 4-hydroxyl-2-pyridone alkaloid is Sambutoxin, and a chemical structure of the 4-hydroxyl-2-pyridone alkaloid is shown in the description. Through researches of animal experiments, cell experiments and the like, the compound is shown to have very strong antitumor activity on varieties of tumor cells including lung cancer, cervical cancer, colon cancer and breast cancer; the compound has the advantages of obvious effects, safety, low toxin, convenience in use and rich and cheap raw material sources; a preparation technology has the advantages of simpleness, high yield, stable characters, convenience in quality control, lower production cost and convenience in application production; anovel medicine source and a safe raw material are provided for treating and researching antitumor and direct related diseases of the antitumor.
Owner:SHANDONG UNIV
Use of polygonin for preparing product for resisting dementia
InactiveCN101411716BEnhance pharmacological effectsRich sourcesOrganic active ingredientsNervous disorderIschemic injuryCerebral ischaemia
The invention relates to application of polydatin which is an extract of polygonum cuspidatum. In-vitro researching experiments show that the polydatin has strong protecting effect for pathological injuries caused by rats multiple infarctional cerebral ischemic injuries, can significantly improve learning memory function of dementia model rats, so the polydatin can be used for preparing a product for resisting vascular dementia and a product, particularly a medicine for resisting senile dementia. The modes for using the polydatin include independent use, or combined use with other chemical substances. Dementia is a key disease impacting health of the elderly, particularly, frequency of disease development of the vascular dementia and the senile dementia is significantly increased to seriously threaten health and life of human beings. The invention provides a novel drug source for clinically treating the vascular dementia and the senile dementia, and has important value for developing and utilizing medicinal plant resource in China.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
New applciation of procyanidine B2
InactiveCN102688230AEasy to solveGood treatment effectOrganic active ingredientsNervous disorderSocial benefitsProcyanidin B2
The invention relates to the technical field of medicines, healthcare products and the like, and particularly to a new application of procyanidine B2 related to active Chinese medicine components in preparation of products, especially medicines and healthcare products for preventing, diagnosing, detecting, protecting, treating and researching vascular dementia, alzheimer disease and diseases directly related to vascular dementia and alzheimer disease. Experiments prove that the procyanidine B2 can enhance the learning and memory capabilities of a mouse with vascular dementia caused by global cerebral ischemia reperfusion injury, a rat with vascular dementia caused by cerebral ischemia reperfusion injury, and a rat with alzheimer disease caused by beta amyloid protein. The compound is strong in action, obvious in effect, abundant in source, stable in property, safe in use, especially wide in use range, and capable of furthest exerting the action thereof. The incidence rate of dementia continuously rises, and the new applciation of procyanidine B2 can generate remarkable social benefits and economic benefits in a short time after being popularized.
Owner:ZHEJIANG XIAOSHAN HOSPITAL
New application of partial metabolite of pentapeptide in preparation of myocardial ischemia resistant product
ActiveCN103203009AEasy to solveGood treatment effectDipeptide ingredientsTetrapeptide ingredientsSerum igeMetabolite
The invention relates to the technical field of biomedicine, and in particular relates to a new application of partial metabolite of pentapeptide in preparation of a myocardial ischemia resistant product. The amino acid sequence of the small peptide is shown as Seq No.2, No.3, No.4, No.5, No.6 and No.7. Through pharmacological experiments of acute rat myocardial ischemia and damage models, the small peptide and the metabolite thereof can remarkably reduce the range of rat myocardial damage and myocardial infarction caused by myocardial ischemia, reduce the content of lactic dehydrogenase and creatine kinase in myocardial ischemia rat serum and have the function of preventing and treating the myocardial ischemia, so the small peptide and the metabolite thereof can be used for preparing a medicament for preventing and treating the myocardial ischemia.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
Antineoplastic traditional Chinese medicine preparation and preparation method thereof
InactiveCN101342179ASolve the problem of poor solubilitySolve the problem of not being easily soluble in waterOrganic active ingredientsPharmaceutical non-active ingredientsChemical synthesisNatural product
An anti-tumor Chinese medicine product comprises medicine, reagent, food and drink and is characterized in that the effective component of the Chinese medicine product is a betulic acid liposome containing betulic acid. The entrapment rate of the betulic acid liposome reaches over 90 percent and particle diameter is 100 to 1000 nanometers. Firstly, the betulic acid plastid is obtained by membrane process; and then the single betulic acid liposome or the betulic acid liposome as well as other chemical substances comprising a pharmaceutically acceptable carrier, the food, a natural product, synthetic chemicals or medicine composition for human are made into the medicine, the food or the drink by general process.
Owner:中国人民解放军第四五四医院 +1
CD20-resistant monoclonal antibody as well as preparation method and application thereof
The invention discloses a humanized CD20-resistant monoclonal antibody. A heavy chain variable region of the humanized CD20-resistant monoclonal antibody has an amino acid sequence as follows: VH: SEQ ID:NO.6; and a light chain variable region has an amino acid sequence as follows: VL:SEQ ID:NO.8. The invention further comprises an application of the monoclonal antibody to the aspects of researches as well as diagnosis and treatment. The invention provides the humanized CD20-resistant monoclonal antibody with high specificity. Compared with a positive medicament, the monoclonal antibody has the advantages of better medicinal effect, simple and convenient preparation process, lower cost, wide application range, and capability of meeting the social requirements, and supplies an accurate, easy, convenient and effective monitoring means for the prevention, treatment, early-stage screening and diagnosis work of cancers and eye diseases. Above all, the CD20-resistant monoclonal antibody positively adapts to the working requirements and the requirement of user-friendly service in the fields of modern biology, prevention and health care, clinical diagnosis and the like; the humanized CD20-resistant monoclonal antibody is researched and developed to provide a treatment medicament with higher cost performance for the medicament market in China; and the CD20-resistant monoclonal antibody has a very wide application prospect.
Owner:张 爱晖
Application of platycodon grandiflorum(Jacq)A .DC polysaccharide for preparing medicine capable of treating cellular damage caused by Cr(VI)
PendingCN110585231AExpansion of medical useImprove developmentOrganic active ingredientsAntinoxious agentsFiberFibroblast
The invention discloses an application of platycodon grandiflorum(Jacq)A .DC polysaccharide for preparing a medicine capable of treating cellular damage caused by Cr(VI). A model for chicken embryo fibroblast line (DF-1 cell) cellular damage caused by Cr(VI) is established to research the function of the platycodon grandiflorum(Jacq)A .DC polysaccharide in the cellular damage. The invention discovers for the first time that the platycodon grandiflorum(Jacq)A .DC polysaccharide of a certain concentration (50-200[mu]g / ml) can resist the cellular damage caused by Cr(VI). The medical application of the platycodon grandiflorum(Jacq)A .DC polysaccharide is widened, and the invention is favorable for developing medicines which take the platycodon grandiflorum(Jacq)A .DC polysaccharide as an effective ingredient and have new indications.
Owner:山东鑫谷健康产业有限公司
Traditional Chinese medicine composition
InactiveCN106309974APracticalSimple preparation processRespiratory disorderImmunological disordersLiquoricesRadix Ophiopogonis
The invention discloses a traditional Chinese medicine composition which is prepared from the following raw materials: xanthium strumarium, rhizoma imperatae, violet magnolia, radix ophiopogonis, radix angelicae, liquorice, luffa stems, dried radix rehmanniae and honeysuckle flowers. Compared with the prior art, the traditional Chinese medicine composition disclosed by the invention has the advantages of short responding time, safety, nontoxicity, low price and practicability, is applicable to most people, takes effect quickly and is convenient to use.
Owner:杨程凯
Application of Edo sakuranin to treatment of Alzheimer
ActiveCN108653308AEnhance pharmacological effectsExpansion of medical useOrganic active ingredientsNervous disorderCell damageApoptosis
The invention discloses application of Edo sakuranin to treatment of Alzheimer. The application has the advantages that experiments prove that the Edo sakuranin can promote the proliferation rate andactivity of a PC-12 cell damaged by A Beta 25-35 and meanwhile can inhibit apoptosis of the PC-12 cell damaged by A Beta 25-35, and a novel method for the treatment of Alzheimer is provided.
Owner:HEILONGJIANG UNIV OF CHINESE MEDICINE
New applciation of procyanidine B2
InactiveCN102688230BTechnical expertiseEnhance pharmacological effectsOrganic active ingredientsNervous disorderSocial benefitsProcyanidin B2
The invention relates to the technical field of medicines, healthcare products and the like, and particularly to a new application of procyanidine B2 related to active Chinese medicine components in preparation of products, especially medicines and healthcare products for preventing, diagnosing, detecting, protecting, treating and researching vascular dementia, alzheimer disease and diseases directly related to vascular dementia and alzheimer disease. Experiments prove that the procyanidine B2 can enhance the learning and memory capabilities of a mouse with vascular dementia caused by global cerebral ischemia reperfusion injury, a rat with vascular dementia caused by cerebral ischemia reperfusion injury, and a rat with alzheimer disease caused by beta amyloid protein. The compound is strong in action, obvious in effect, abundant in source, stable in property, safe in use, especially wide in use range, and capable of furthest exerting the action thereof. The incidence rate of dementia continuously rises, and the new applciation of procyanidine B2 can generate remarkable social benefits and economic benefits in a short time after being popularized.
Owner:ZHEJIANG XIAOSHAN HOSPITAL
Anti-CD20 monoclonal antibody, preparation method and application thereof
InactiveCN103012590BPracticalSimple preparation processAntipyreticAnalgesicsAbnormal tissue growthImmunologic disorders
Owner:SHANGHAI HANKANG BIO PHARMA TECH
A group of traditional Chinese medicine extracts with adenosine deaminase inhibitory activity and their application
ActiveCN108096387BExpansion of medical useEnhanced inhibitory effectAntibacterial agentsNervous disorderTherapeutic effectSedum sarmentosum
The invention relates to a traditional Chinese medicine extract with adenosine deaminase inhibition activity and an application of the traditional Chinese medicine extract. A preparation method of thetraditional Chinese medicine extract comprises the steps of taking traditional Chinese medicinal material powder, adding methanol, performing ultrasound extraction under a sealed condition, after theultrasound extraction, complementing the lost weight with methanol, performing centrifugation, taking a supernate, performing nitrogen blow-drying to form an extract, namely the traditional Chinese medicine extract, wherein traditional Chinese medicines are radix bupleuri, ligusticum wallichii, Chinese angelica, radix sophorae flavescentis, artemisia capillaris, bighead atractylodes rhizome, folium isatidis, a glossy privet fruit, schisandra chinensis, gardenia, rheum palmatum, sinensis, rhizoma cimicifugae, pollen pini, polygonum cuspidatum or sedum sarmentosum. After determination by established liquid chromatography-tandem mass spectrometry, the traditional Chinese medicine extract has a stronger inhibiting effect on adenosine deaminase, and cell experiments and animal experiments further confirm that the traditional Chinese medicine extract has a significant treatment effect on leukemia and the like.
Owner:SHANGHAI UNIV OF T C M
Application of a kind of 4-hydroxyl-2-pyridone alkaloid in the preparation of anti-tumor products
ActiveCN107536833BStrong activationEasy to prepareOrganic active ingredientsOrganic chemistryDiseaseAlkaloid
The invention discloses application of 4-hydroxyl-2-pyridone alkaloid in preparing an antitumor product. The 4-hydroxyl-2-pyridone alkaloid is Sambutoxin, and a chemical structure of the 4-hydroxyl-2-pyridone alkaloid is shown in the description. Through researches of animal experiments, cell experiments and the like, the compound is shown to have very strong antitumor activity on varieties of tumor cells including lung cancer, cervical cancer, colon cancer and breast cancer; the compound has the advantages of obvious effects, safety, low toxin, convenience in use and rich and cheap raw material sources; a preparation technology has the advantages of simpleness, high yield, stable characters, convenience in quality control, lower production cost and convenience in application production; anovel medicine source and a safe raw material are provided for treating and researching antitumor and direct related diseases of the antitumor.
Owner:SHANDONG UNIV
Melamine antigen, related antibody and preparation method thereof
InactiveCN102702345BSynthetic properties and stable structureGood synthesis reproducibilityOvalbuminSerum albuminAntigenPolyaldehyde-dextran
The invention relates to a melamine antigen, a related antibody and a preparation method thereof. Melamine and carrier protein are coupled by using PAD (polyaldehyde dextran) as bridge reagent; coupling products is used to immunize animals to prepare monoclonal antibodies for detecting melamine. Artificially-prepared melamine antigen and related antibody provided by the invention can be used for researching and developing melamine immunity detection reagents to meet detection demand on low cost, rapidity and convenient operations.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Application of Platycodon grandiflorum total polysaccharide in the preparation of medicine for the treatment of apoptosis induced by cccp
ActiveCN110200987BExpansion of medical useReduce damageOrganic active ingredientsAntineoplastic agentsCell activityMitochondrial pathway
The invention discloses the application of the total polysaccharide of Platycodon grandiflorum in preparing a medicine for treating cell apoptosis induced by CCCP. The invention uses CCCP to establish a cell apoptosis model caused by mitochondrial pathway, and studies the effect of Platycodon grandiflorum total polysaccharide on cell activity and cell apoptosis after CCCP induces oxidative damage in porcine alveolar macrophages. The present invention finds for the first time that a certain concentration of Platycodon grandiflorum total polysaccharide (100-200 μg / mL) can antagonize cell apoptosis caused by CCCP, significantly reduce the phenomenon of nuclear deformation, and inhibit the change of mitochondrial membrane potential. The invention expands the medical application of the total polysaccharide of Platycodon grandiflorum, and is beneficial to the development of medicines with new indications that use the total polysaccharide of Platycodon grandiflorum as an effective ingredient.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Application of anthocyanin in preparation of medicine for treating cell damage caused by p-aminophenylarsenic acid
ActiveCN108272793BApoptosis antagonismExpansion of medical useOrganic active ingredientsAntinoxious agentsCytotoxicityApoptosis
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com