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New applciation of procyanidine B2

A proanthocyanidin, dementia technology, applied in the field of medicine, health care products, beverages, and food, can solve the problems that have not yet been found in the application report of proanthocyanidin B2 anti-dementia products, and achieve good preventive and therapeutic effects

Inactive Publication Date: 2014-12-03
ZHEJIANG XIAOSHAN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0111] However, through literature search, etc., so far, no report on the application of proanthocyanidin B2 as an anti-dementia product has been found.

Method used

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  • New applciation of procyanidine B2
  • New applciation of procyanidine B2
  • New applciation of procyanidine B2

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0241] As for Proanthocyanidin B 2 The preparation method is a mature method, which has been published in various journals and patent documents, and will not be repeated in the present invention.

[0242] In the present invention, the specific implementation manners described above and the examples described below are for better illustrating the present invention, and are not used to limit the scope of the invention.

Embodiment 1

[0244] Embodiment 1, the preparation of proanthocyanidin B2 tablet

[0245] Prescription:

[0246]

[0247] Process:

[0248] Pass proanthocyanidin B2 through an 80-mesh sieve, mix with starch, lactose, and sodium carboxymethyl starch, and add starch slurry to make a soft material. Granulate through a 16-mesh sieve, dry below 60°C, granulate, add magnesium stearate, mix well, and compress into tablets. It can be made into 1000 tablets each containing 100mg proanthocyanidin B2.

Embodiment 2

[0249] Embodiment 2, the preparation of proanthocyanidin B2 capsules

[0250] Prescription:

[0251]

[0252] Process:

[0253] Proanthocyanidin B2 passes through an 80-mesh sieve, mixes with the prescribed amount of starch and micropowder silica gel, and directly packs it into capsules to make capsules containing 100 mg of proanthocyanidin B2.

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Abstract

The invention relates to the technical field of medicines, healthcare products and the like, and particularly to a new application of procyanidine B2 related to active Chinese medicine components in preparation of products, especially medicines and healthcare products for preventing, diagnosing, detecting, protecting, treating and researching vascular dementia, alzheimer disease and diseases directly related to vascular dementia and alzheimer disease. Experiments prove that the procyanidine B2 can enhance the learning and memory capabilities of a mouse with vascular dementia caused by global cerebral ischemia reperfusion injury, a rat with vascular dementia caused by cerebral ischemia reperfusion injury, and a rat with alzheimer disease caused by beta amyloid protein. The compound is strong in action, obvious in effect, abundant in source, stable in property, safe in use, especially wide in use range, and capable of furthest exerting the action thereof. The incidence rate of dementia continuously rises, and the new applciation of procyanidine B2 can generate remarkable social benefits and economic benefits in a short time after being popularized.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food, health products and beverages, in particular to a new application of active ingredients of traditional Chinese medicine, more specifically to a new application of proanthocyanidin compounds, and more specifically to proanthocyanidin B2 (Also known as: Proanthocyanidin B 2 ) for new uses. Background technique [0002] 1. Research overview of proanthocyanidin B2 [0003] 1. Anthocyanins [0004] Anthocyanins are water-soluble pigments that can change color with the acidity and alkalinity of the cell fluid. The cell fluid is acidic and reddish, and the cytosol is alkaline and blue. Anthocyanins are one of the main pigments that make up the color of petals and fruits. Generated via phenylpropanoid pathway and flavonoids biosynthetic pathway. [0005] Factors affecting the coloration of anthocyanins include the structure of anthocyanins, pH value, copigmentation, etc. Peel color...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P25/28A61P9/00A23L1/29A23L33/00
Inventor 蒋国军徐超斗毛峻琴路明珠李铁军张敏敏廖丽娜
Owner ZHEJIANG XIAOSHAN HOSPITAL
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