137 results about "Lipid peroxidation" patented technology

The invention discloses a Staphylococcus edaphicus H3, the preservation number of the Staphylococcus edaphicus H3 in Guangdong Microbial Culture Collection Center is GDMCC No: 64958, the strain H3 is applied to fermentation of meat products without nitrite, the Staphylococcus edaphicus H3 can promote color development of the meat products, and the Staphylococcus edaphicus H3 has relatively strong oxidation resistance, can effectively inhibit lipid peroxidation, and can be used for preparing the meat products. The staphylococcus aureus H3 can produce polysaccharide, the polysaccharide also plays an anti-oxidation role in a meat product processing process and is beneficial to maintenance of meat color, the strain H3 is inoculated to ferment sausages, the nitrite content in the sausages is obviously reduced, the hardness, cohesiveness, elasticity and chewiness of the sausages are improved, the taste of the sausages is richer, the delicate flavor is increased, and the sausages are more delicious. The strain H3 has no blood coagulation and hemolysis effects, is safe and reliable as a food additive, and is suitable for industrial production and market popularization and application.

The invention discloses photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking as well as a preparation method and application of the photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking, the hydrogel is prepared by taking azide group-containing four-arm polyethylene glycol and alkynyl modified hyaluronic acid as matrixes through click chemistry rapid crosslinking under the catalysis of copper-based nanoparticles, the antibacterial biological membrane has remarkable dual anti-biological membrane and anti-inflammatory effects, and can be applied to wound treatment of bacterial biological membrane infection; through a wound surface coating form, under near-infrared light irradiation, copper nanoparticles generate a mild photothermal effect to remove a biological membrane, and Cu < 2 + > is released to promote fibroblast proliferation; nitric oxide can be controllably released, a biological membrane is synergistically eliminated by enhancing lipid peroxidation and destroying a bacterial membrane structure, meanwhile, angiogenesis is promoted, collagen deposition is stimulated, and the wound healing process is accelerated; the invention has the functions of efficient antibiosis and tissue regeneration, and has wide clinical application prospect and development value in the field of infectious wound treatment.

The invention provides a preparation method of collagen and an application of the collagen in anti-aging. According to the invention, the anti-aging antioxidant collagen peptide F-5-B is obtained through enzymolysis and column separation identification. It is identified that the polypeptide has good DPPH free radical scavenging capacity, ABTS free radical scavenging capacity and lipid peroxidation reaction inhibiting capacity, the collagen peptide F-5-B can further inhibit melanoma cells from synthesizing melanin, and the polypeptide can further obviously increase the SOD level in the liver of a mouse. SOD can help the body resist attack of free radicals, so that the aging process is slowed down. Therefore, the anti-aging pharmaceutical composition prepared from the polypeptide has a relatively good application prospect.

A preparation method, a use, and a quality detection method of a Panax notoginseng-Bletilla striata oral liquid are provided. The preparation method is simple and close to the traditional Chinese medicine preparation technology. An oral liquid solution finally prepared is clear, has a high viscosity, and exhibits better efficacy than the primary drug. In the present disclosure, the prepared Panax notoginseng-Bletilla striata oral liquid is used for the first time in preparation of an antialcoholic and hepatoprotective product. Research results show that the oral liquid can enhance the oxidation resistance of endogenous antioxidase such as glutathione (GSH) to some degree, inhibit an impact of free radical-mediated lipid peroxidation on a liver injury, and exhibit a prominent antialcoholic and hepatoprotective effect for drunk mice. The quality and efficacy of an oral liquid can be monitored scientifically by the quality detection method.

The invention provides an application of a lactobacillus paracasei IOB413 metagen in prevention of helicobacter pylori infection, and relates to the technical field of microorganisms. The lactobacillus paracasei IOB413 metaplasm can competitively occupy gastric epithelial cell adhesion sites to directly block the initial colonization of helicobacter pylori, so that infection preposed interception is realized, and the lactobacillus paracasei IOB413 metaplasm is suitable for early prevention of high-incidence people. The compound has dual mechanisms of site blocking and urease inhibition, and can cooperate with antibiotics to improve the eradication rate and reduce the drug resistance. Animal experiments show that the traditional Chinese medicine composition can reduce gastric mucosa proinflammatory factors in a dose-dependent manner, improve the activity of antioxidant enzymes, reduce lipid peroxidation products, relieve mucosa lesion, promote repair and reduce the risk of complications; moreover, gastrointestinal hormone disorder can be reversed, the digestive function is maintained, and related discomfort is relieved.

The invention belongs to the technical field of medicines, and particularly relates to a plant lactobacillus for relieving acute alcoholic liver injury as well as a metagen and application of the plant lactobacillus. The strain of the plant lactobacillus L5-13 is preserved in the China Center for Type Culture Collection on August 18, 2025, and the preservation number of the strain is CCTCC NO: M 20251835. The strain and the metagen thereof can significantly improve pathological symptoms of mice with acute alcoholic liver injury, including: reducing the levels of ALT, AST, TC, TG and LDL-C in serum of the mice with acute alcoholic liver injury, and increasing the level of HDL-C; the abnormal blood lipid level of the mouse caused by acute alcohol is regulated; the activity of antioxidant enzymes in the liver is improved, and the lipid peroxidation level is reduced; the ethanol dehydrogenase activity of the liver is improved, and the ethanol metabolism capability is enhanced. Therefore, the strain and the metagen thereof have wide application prospects in prevention or treatment of acute alcoholic liver injury.

The invention discloses a composition formula for assisting in protecting the liver and dispelling the effects of alcohol, and relates to the field of health food, the composition has an assisting effect on protecting the liver and dispelling the effects of alcohol, and the composition comprises the following composition components: milk thistle (0.466-0.482), puerarin (0.069-0.075), globe artichoke extract (0.065-0.072), glutathione (0.04-0.049), dandelion extract (0.151-0.164) and hydrogen butyric acid (0.146-0.162). By adopting the composition formula for assisting in protecting the liver and eliminating the alcohol, the composition has obvious effects of inhibiting the liver from generating lipid oxide and assisting the human liver in eliminating oxide substances, and meanwhile, the composition can be used for preventing lipid peroxidation damage by improving the activity of glutathione reductase and improving the antioxidant effect; therefore, the effects of protecting the liver and reducing injury are achieved. The components of the composition are equal-part particles formed by physical stirring and uniform mixing, the components are complementary and synergistic, the composition is safe and free of side effects to human bodies, the raw materials of the composition formula are convenient to purchase, the production benefits are high, and wide application is facilitated.

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.

The invention discloses a preparation method of a dairy cow placenta extract CP1 and application of the dairy cow placenta extract CP1 as an antioxidant substance. The preparation method comprises the following steps: taking normal delivery healthy Chinese Holstein dairy cow placenta homogenate as a substrate, shearing the dairy cow placenta into pieces, homogenizing by adopting a tissue homogenizer, adding papain, and acting for 4.7 hours under the conditions that the pH is 6.5 and the temperature is 55 DEG C; the antioxidative peptide has the advantages that the antioxidative peptide with five potential types is screened by the aid of virtual screening processes after the antioxidative peptide is inactivated in boiling water bath for 10 minutes, affinity of the antioxidative peptide with Keap1 after molecular docking is higher than that of TX6, the affinity of ANNGKQWAEVF with Keap1 is the strongest, accordingly, the antioxidative peptide is marked as CP1, the CP1 is excellent in free radical scavenging capacity, lipid peroxidation inhibition capacity, transition metal chelating capacity and reducing power, and the antioxidative peptide with the antioxidative peptide can be used for preparing antioxidative peptide products. In addition, a Keap1 / Nrf2 pathway in oxidative stress cells can be activated, so that the oxidative stress of the cells is relieved, and the compound can be applied as an antioxidant substance.

The invention discloses application of a compound in preparation of a skin and / or scalp care product, the structural formula of the compound is # imgabs0, and compared with retinoic acid, the compound provided by the invention has higher cell safety concentration and lower irritation, has a more excellent effect in the aspect of cell damage repair, and has a better cell moisturizing effect; compared with the retinyl phytosphingosine, the compound provided by the invention has a better effect in the aspects of inhibiting the activity of elastase and improving type I collagen; compared with retinoyl phytosphingosine, the compound provided by the invention shows a better effect in the aspects of resisting lipid peroxidation and inhibiting malassezia reproduction, and also has better stability. The compound provided by the invention has good application value in the field of preparing cosmetics, medicines and health care products with corresponding effects or indications.

The invention discloses a traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation for improving oral bacterial flora and a preparation process thereof, and relates to the related field of biotechnology. According to the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation, the synergistic effect of probiotics and traditional Chinese medicine is combined, the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation has the multiple advantages of regulating oral flora, resisting bacteria and diminishing inflammation, resisting oxidation, relieving fatigue and the like, lactobacillus acidophilus NM can tolerate acid and cholate, pathogenic bacteria such as escherichia coli, staphylococcus aureus and salmonella are effectively inhibited, and the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation is suitable for oral administration. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can be used for reducing dental caries, gingivitis and ozostomia, is free of antibiotic drug resistance and is safer after being used for a long time, radix scutellariae, honeysuckle and green tea extracts are rich in flavonoids and tea polyphenols and can further resist bacteria and inflammation and improve oral health, and meanwhile, the probiotics can reduce blood lactic acid, blood urea nitrogen and blood ammonia, enhance SOD, CAT and GSH-Px vitality and inhibit lipid peroxidation, so that body fatigue is relieved, and the traditional Chinese medicine composition can be used for preventing and treating dental caries, gingivitis and ozostomia. The immunity is improved, and preparation forms are diversified.

The invention discloses a single-chain alkylamino glycerol compound, a preparation method and application. The structural general formula of the single-chain alkylamino glycerol compound is R-NH-CH2-CHOH-CH2OH, the single-chain alkylamino glycerol compound is used for preventing and controlling peach monilinia and / or botryosphaeria dothidea, and R is a C8-C18 straight chain or branched chain and saturated or unsaturated alkyl. The single-chain alkylamino glycerol compound provided by the invention can be prepared by reacting glycidol and alkylamine under mild conditions, has a remarkable inhibition effect on peach monilinia and botryosphaeria dothidea, and can induce fungal membrane rupture, anti-oxidation system imbalance and lipid peroxidation, so that fungus killing is realized. The device can be widely used for fruit and vegetable postharvest preservation, orchard spraying and green pesticide development.

The antioxidant activity of alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and of alpha-tocopherol succinate (TS) has been examined in isolated hepatocytes and microsomal fractions from rat liver. Both TPGS and TS require esterase activity to yield free alpha-tocopherol and, hence, antioxidant activity. TPGS and TS consistently exerted a more effective antioxidant protection than an equivalent amount of directly-added free alpha-tocopherol. The low antioxidant efficiency of directly added free alpha-tocopherol in such water-based experimental systems as used here seems to be due to its extreme hydrophobicity. TPGS, on the other hand, is an extremely hydrophilic compound which is being examined as a useful source of alpha-tocopherol in certain clinical situations and is here shown to be a convenient and effective source for experimental studies into lipid peroxidation and antioxidant mechanisms.

The invention discloses a post-harvest castanea mollissima calcification prevention and control method based on inhibition of lipoxygenase activity by salicylic acid, and belongs to the technical field of agricultural product preservation. Research finds that salicylic acid can inhibit lipoxygenase-mediated fatty acid oxidation, change lipid metabolism of chestnut kernels, increase the content of unsaturated fatty acid in the chestnut kernels, reduce lipid peroxidation and maintain cell integrity, so that calcification after chestnut harvesting is delayed or inhibited. The water content of the Chinese chestnuts can be kept, and a new target and strategy are provided for research and development of a preservative for inhibiting calcification of the Chinese chestnuts after harvesting and improvement of the storage quality and shelf life of the Chinese chestnuts and other horticultural crops after harvesting.

The present application belongs to the field of biological medicine and molecular biology technology, and particularly relates to a marker for predicting the occurrence of repeated implantation failure and application thereof. The present application finds that abnormal lipid peroxidation in uterine epithelium can cause implantation defects, and the lipid peroxidation level of the uterus in patients with repeated implantation failure or repeated spontaneous abortion is enhanced, wherein the content of active aldehyde substance MDA and non-heme iron in serum can be used as a new non-invasive clinical index for predicting RIF patients; further, eliminating uterine lipid ROS to improve endometrial receptivity can be used as a potential new treatment strategy to improve embryo implantation and clinical pregnancy rate, and therefore has good practical application value.

The application provides an engineered probiotic with intracellular chimeric nanoscale enzyme, which is a probiotic modified with several antioxidant enzymes on an inner membrane; the antioxidant enzyme is composed of a metal oxide nanoscale enzyme with a particle size less than 10 nm and a targeting molecular structure and a saccharide molecular structure modified on the surface of the metal oxide nanoscale enzyme; the targeting molecular structure and the saccharide molecular structure are connected to the surface of the metal oxide nanoscale enzyme through a connecting group containing a metal ligand structure based on coordination and electrostatic interaction, and the antioxidant enzyme accounts for 5-20% of the mass of the engineered probiotic. The application also provides a method for preparing the engineered probiotic and application of the engineered probiotic in preparation of a medicine or food for preventing or treating antibiotic-associated diarrhea. The engineered probiotic can realize efficient elimination of hydroxyl radicals near a membrane induced by an antibiotic, so as to accurately inhibit a lipid peroxidation reaction and protect the integrity of a cell membrane.

The invention discloses application of ellagic acid in preparation of a medicine or a biological product for preventing or relieving ultraviolet radiation damage and aging, and belongs to the technical field of biological medicine and radiation protection. Experimental verification shows that ellagic acid with effective concentration can promote expression of antioxidant related genes, reduce expression of inflammation response genes and expression of apoptosis related genes, eliminate active oxygen and inhibit lipid peroxidation reaction, so that oxidative damage, inflammatory reaction and apoptosis caused by ultraviolet radiation are effectively relieved, and the anti-inflammatory effect of ellagic acid is improved. The stress tolerance of an organism is improved, and the aging health risk induced by ultraviolet radiation is relieved; the medicine or biological product can be applied before and / or after exposure of ultraviolet radiation, and is suitable for preventing or relieving oxidative damage and cell aging caused by ultraviolet radiation. The invention provides a new way for developing safe and effective ultraviolet radiation protection and anti-aging preparations.

This invention discloses a pharmaceutical composition for treating asthenospermia by activating the Nrf2 / HO-1 / GPx4 pathway and its application. The pharmaceutical composition comprises taurine and geranium as active ingredients, wherein the mass ratio of taurine to geranium is 3-5:1. The pharmaceutical composition of this invention can synergistically activate the Nrf2 / HO-1 / GPx4 antioxidant signaling pathway, upregulate the expression of downstream antioxidant enzymes GPx4 and HO-1, inhibit lipid peroxidation, protect sperm mitochondrial function, and simultaneously improve the microenvironmental metabolic profile of the epididymis—the site of sperm maturation—thereby enhancing sperm motility. The pharmaceutical composition provided by this invention can be used to prepare a treatment for asthenospermia, particularly oxidative stress-induced asthenospermia.

The present invention discloses a traditional Chinese medicine compound Lactobacillus acidophilus NM probiotic preparation for improving oral bacterial flora and its preparation process, which relates to the related field of biotechnology. The traditional Chinese medicine compound Lactobacillus acidophilus NM probiotic preparation of the present invention combines the synergistic effects of probiotics and traditional Chinese medicine, and has multiple advantages such as regulating oral flora, antibacterial and anti-inflammatory, antioxidant, and relieving fatigue. Lactobacillus acidophilus NM can tolerate acid and bile salts, effectively inhibit pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Salmonella, reduce the occurrence of dental caries, gingivitis, and halitosis. It has no antibiotic resistance and is safer for long-term use. The extracts of Scutellaria baicalensis, honeysuckle, and green tea are rich in flavonoids and tea polyphenols, which can further antibacterial and anti-inflammatory and improve oral health. At the same time, this probiotic can reduce blood lactic acid, blood urea nitrogen, and blood ammonia, enhance the activities of SOD, CAT, and GSH-Px, and inhibit lipid peroxidation, thereby relieving body fatigue and enhancing immunity. The preparation forms are diverse.

The invention relates to dahurian rose fruit blended tea and a preparation method thereof. The tea bag electuary is prepared by processing the dahurian rose fruit, the ginseng, the sweet-scented osmanthus and the linden honey, and wild natural raw materials are selected, so that pesticide residues are avoided, and the tea bag electuary is greener and healthier. The linden honey is used for pressing the original taste of the ginseng, the sweet-scented osmanthus is used for improving the fragrance of the whole tea drink, the original rose fragrance and slightly bitter taste of the dahurian rose fruit are exerted, and the dahurian rose fruit tea drink is sweet and sweet after taste. The tea bag product better adapts to the brewing habit of consumers, is convenient to carry and store, has no influence on the efficacy of the product, is simple in production process and easy to control, and can meet the carrying and eating requirements of the consumers. The formula preparation has good effects of removing oxygen free radicals and preventing lipid peroxidation to generate lipid peroxides, has a protection effect on cell metabolism and functions, and has obvious effects of protecting liver and eyes and resisting fatigue. After the components are combined, a plurality of anti-fatigue action targets can be enhanced in a synergistic and integrated manner, so that better anti-alcohol, liver-protecting, eye-protecting and anti-fatigue effects are achieved.

The invention relates to the technical field of biology, and provides a composition, a culture solution, a product and a method for promoting embryo ectogenesis. The composition is prepared from 8-Br-cGMP and glycyrrhizic coumarin. The composition can reduce the lipid peroxidation level of embryos and reduce the toxic effect of lipid peroxidation on the embryos. Meanwhile, fat hydrolysis and oxidation energy supply can be promoted, and sufficient energy guarantee is provided for in-vitro development of early embryos. In addition, the composition can effectively reduce the active oxygen level in the embryo and reduce the damage of oxidative stress to the embryo. By adopting the composition disclosed by the invention, the embryo ectogenesis can be promoted, and the in-vitro blastocyst formation rate can be increased.

The invention provides a 9, 10-dihydrophenanthrene compound and application thereof in liver injury treatment, and particularly provides a compound shown as a formula I or a compound shown as a formula II, which shows anti-inflammatory and antioxidant activity in liver tissues, so that the 9, 10-dihydrophenanthrene compound can be used for treating liver injury diseases, such as liver injury diseases and liver injury diseases. Particularly, the liver injury diseases with inflammation and lipid peroxidation as pathological basis can be treated or prevented. # imgabs0 #

The invention discloses application of ellagic acid in preparation of a medicine for preventing or treating ionizing radiation injury, and belongs to the technical field of biological medicine and radiation protection. Experiments prove that ellagic acid with an effective concentration can inhibit lipid peroxidation, enhance the activity of glutathione transferase and superoxide dismutase and promote the expression of antioxidant related genes such as sod-1, sod-2, gst-1 and gst-29 and immune related genes such as lys-1, irg-1, irg-2 and mul-1, so that the ellagic acid with an effective concentration can inhibit lipid peroxidation and improve the activity of glutathione transferase and superoxide dismutase. Therefore, oxidative damage, inflammatory response, reduced stress tolerance, accelerated aging and shortened service life caused by ionizing radiation exposure are relieved, and the compound can be applied to preparation of drugs for preventing or treating ionizing radiation damage and is suitable for nuclear accident emergency protection, space radiation protection of astronauts and adjuvant therapy of tumor radiotherapy patients. The invention provides a theoretical basis for developing an efficient and low-toxicity ionizing radiation protective agent based on ellagic acid, and has a wide application prospect.

The invention relates to an ion-resistant liposome as well as a preparation method and application thereof, and belongs to the technical field of liposome preparation, and the ion-resistant liposome comprises a water-phase active component, an oil-phase active component and a membrane material. According to the membrane material disclosed by the invention, lecithin and polyglycerol-10 myristate are compounded, so that the interface stability of the lipidosome is synergistically enhanced, and the prepared lipidosome finished product effectively has an outstanding effect of resisting damage of metal ions to the lipidosome structure; in addition, in the water-phase active component and the oil-phase active component, key fruit oil, a caulis polygoni cuspidati seed extract and terminalia bellirica fruit water are combined for use, so that the prepared lipidosome has an excellent anti-oxidation effect through different-dimension synergistic effects of reducing lipid peroxidation, reducing the free radical level and removing various free radicals; the bunge cherry seed extract, the buckeye valeriana seed fat, the samara oil and the roselle flower extract can achieve the synergistic effect of moisturizing and locking water and improving the skin barrier function, so that the prepared liposome has excellent moisturizing and moisturizing effects.

The invention discloses a rosa roxburghii tratt fruit composite beverage with a hangover alleviating effect and a preparation method and application thereof, and belongs to the technical field of biology. The roxburgh rose beverage disclosed by the invention comprises the following raw materials in parts by weight on the basis of 100 parts by weight: 8-16 parts of roxburgh rose concentrated juice, 5-15 parts of crystalline fructose, 0.8-2.5 parts of soybean peptide powder, 0.8-1.8 parts of yeast extract and the balance of water. Experiments prove that the formula product has the advantages of moderate taste, aromatic flavor, good stability and the like, and can keep stable taste and flavor during long-term storage. Animal experiments verify that the roxburgh rose beverage has an obvious hangover alleviating effect by improving ALDH activity, accelerating ethanol metabolism and reducing blood ethanol mass concentration, can improve liver injury caused by drinking by increasing liver SOD, GSH-Px, CAT activity and GSH content, reducing MDA content, enhancing body antioxidant ability and inhibiting lipid peroxidation reaction, and has a liver protection effect.

The embodiment of the invention provides application of hydroxymethoxyphenyl decanone in preparation of a cosmetic composition for preventing squalene in sebum from being oxidized. According to the embodiment of the invention, the hydroxymethoxyphenyl decanone is used as an antioxidant to prepare the cosmetic composition, and when the cosmetic composition is applied to skin, squalene in sebum can be prevented from being oxidized; wherein the hydroxymethoxyphenyl decanone, as an antioxidant, can be used for reducing the peroxide value of squalene in sebum or inhibiting the squalene in the sebum from being oxidized into squalene peroxide products, so that lipid peroxidation of the squalene in the sebum is effectively inhibited or avoided; further, the problems of skin inflammation, hyperpigmentation, scurf and the like caused by squalene peroxide products can be defended and improved.

The invention discloses a skin care composition containing bakuchiol and rosmarinic acid and application of the skin care composition. The composition comprises bakuchiol and rosmarinic acid in a physiologically acceptable medium. According to the composition, the bakuchiol and the rosmarinic acid are compounded for use, and the composition shows a very good synergistic effect in the aspect of inhibiting lipid peroxidation.

The invention provides an oligopeptide, and a lentiviral expression vector and a recombinant cell for expressing the oligopeptide. The invention further provides application of the compound in tumor treatment. After the oligopeptide is delivered to HT1080 cells through a lentivirus system, the intracellular SLC7A11 protein level is reduced, the intracellular Fe < 2 + > and lipid peroxidation level is remarkably increased, and the oligopeptide has a remarkable inhibition effect on cell proliferation and has the tumor treatment potential.

The invention discloses application of a preparation capable of improving glutathione concentration in reversing osimertinib drug resistance. The invention also discloses a pharmaceutical composition for treating the drug-resistant lung cancer, and the pharmaceutical composition comprises a preparation capable of improving the concentration of glutathione (GSH) and osimertinib (AZD9291). The invention finds that the combination of GSH and AZD9291 has a synergistic effect, the combination of 3mM GSH and 1 mu M osimertinib can inhibit the proliferation of non-small cell lung cancer, the inhibition rate is significantly higher than that of the single use of AZD9291, and the combination of GSH and osimertinib has a synergistic inhibition effect on AZD9291 drug-resistant NSCLC cells. Meanwhile, the intracellular lipid peroxidation level of lung cancer cells is remarkably improved through GSH treatment, and the treatment effect of AZD9291 on NSCLC is enhanced.

The invention relates to the field of health-care products, and discloses an antioxidant and anti-aging organic selenium health-care product and a preparation method of the antioxidant and anti-aging organic selenium health-care product. Comprising the following raw materials in parts by weight: 0.1-0.3 part of organic selenium, 20-30 parts of a rehmannia root extract, 10-20 parts of a ginseng extract, 40-50 parts of a Chinese wolfberry fruit extract, 3-8 parts of vitamin E, 1-3 parts of zinc aspartate, 1-5 parts of alpha-ketoglutaric acid and 50 parts of maltodextrin. The strong free radical scavenging capacity is achieved through organic selenium, and various active ingredients in the radix rehmanniae extract, the ginseng extract and the fructus lycii extract have a synergistic effect from multiple aspects of regulating cell metabolism, enhancing cell viability and the like, so that the overall health state of an organism is improved; the vitamin E further strengthens an antioxidant defense line and blocks lipid peroxidation reaction; zinc aspartate assists the maintenance of normal physiological functions of the cells; and the alpha-ketoglutaric acid can delay the cell aging process.