109 results about "Lipid peroxidation" patented technology

The invention discloses photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking as well as a preparation method and application of the photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking, the hydrogel is prepared by taking azide group-containing four-arm polyethylene glycol and alkynyl modified hyaluronic acid as matrixes through click chemistry rapid crosslinking under the catalysis of copper-based nanoparticles, the antibacterial biological membrane has remarkable dual anti-biological membrane and anti-inflammatory effects, and can be applied to wound treatment of bacterial biological membrane infection; through a wound surface coating form, under near-infrared light irradiation, copper nanoparticles generate a mild photothermal effect to remove a biological membrane, and Cu < 2 + > is released to promote fibroblast proliferation; nitric oxide can be controllably released, a biological membrane is synergistically eliminated by enhancing lipid peroxidation and destroying a bacterial membrane structure, meanwhile, angiogenesis is promoted, collagen deposition is stimulated, and the wound healing process is accelerated; the invention has the functions of efficient antibiosis and tissue regeneration, and has wide clinical application prospect and development value in the field of infectious wound treatment.

The invention provides an application of a lactobacillus paracasei IOB413 metagen in prevention of helicobacter pylori infection, and relates to the technical field of microorganisms. The lactobacillus paracasei IOB413 metaplasm can competitively occupy gastric epithelial cell adhesion sites to directly block the initial colonization of helicobacter pylori, so that infection preposed interception is realized, and the lactobacillus paracasei IOB413 metaplasm is suitable for early prevention of high-incidence people. The compound has dual mechanisms of site blocking and urease inhibition, and can cooperate with antibiotics to improve the eradication rate and reduce the drug resistance. Animal experiments show that the traditional Chinese medicine composition can reduce gastric mucosa proinflammatory factors in a dose-dependent manner, improve the activity of antioxidant enzymes, reduce lipid peroxidation products, relieve mucosa lesion, promote repair and reduce the risk of complications; moreover, gastrointestinal hormone disorder can be reversed, the digestive function is maintained, and related discomfort is relieved.

The invention belongs to the technical field of medicines, and particularly relates to a plant lactobacillus for relieving acute alcoholic liver injury as well as a metagen and application of the plant lactobacillus. The strain of the plant lactobacillus L5-13 is preserved in the China Center for Type Culture Collection on August 18, 2025, and the preservation number of the strain is CCTCC NO: M 20251835. The strain and the metagen thereof can significantly improve pathological symptoms of mice with acute alcoholic liver injury, including: reducing the levels of ALT, AST, TC, TG and LDL-C in serum of the mice with acute alcoholic liver injury, and increasing the level of HDL-C; the abnormal blood lipid level of the mouse caused by acute alcohol is regulated; the activity of antioxidant enzymes in the liver is improved, and the lipid peroxidation level is reduced; the ethanol dehydrogenase activity of the liver is improved, and the ethanol metabolism capability is enhanced. Therefore, the strain and the metagen thereof have wide application prospects in prevention or treatment of acute alcoholic liver injury.

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.

The invention discloses a single-chain alkylamino glycerol compound, a preparation method and application. The structural general formula of the single-chain alkylamino glycerol compound is R-NH-CH2-CHOH-CH2OH, the single-chain alkylamino glycerol compound is used for preventing and controlling peach monilinia and / or botryosphaeria dothidea, and R is a C8-C18 straight chain or branched chain and saturated or unsaturated alkyl. The single-chain alkylamino glycerol compound provided by the invention can be prepared by reacting glycidol and alkylamine under mild conditions, has a remarkable inhibition effect on peach monilinia and botryosphaeria dothidea, and can induce fungal membrane rupture, anti-oxidation system imbalance and lipid peroxidation, so that fungus killing is realized. The device can be widely used for fruit and vegetable postharvest preservation, orchard spraying and green pesticide development.

The antioxidant activity of alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and of alpha-tocopherol succinate (TS) has been examined in isolated hepatocytes and microsomal fractions from rat liver. Both TPGS and TS require esterase activity to yield free alpha-tocopherol and, hence, antioxidant activity. TPGS and TS consistently exerted a more effective antioxidant protection than an equivalent amount of directly-added free alpha-tocopherol. The low antioxidant efficiency of directly added free alpha-tocopherol in such water-based experimental systems as used here seems to be due to its extreme hydrophobicity. TPGS, on the other hand, is an extremely hydrophilic compound which is being examined as a useful source of alpha-tocopherol in certain clinical situations and is here shown to be a convenient and effective source for experimental studies into lipid peroxidation and antioxidant mechanisms.

The invention discloses a post-harvest castanea mollissima calcification prevention and control method based on inhibition of lipoxygenase activity by salicylic acid, and belongs to the technical field of agricultural product preservation. Research finds that salicylic acid can inhibit lipoxygenase-mediated fatty acid oxidation, change lipid metabolism of chestnut kernels, increase the content of unsaturated fatty acid in the chestnut kernels, reduce lipid peroxidation and maintain cell integrity, so that calcification after chestnut harvesting is delayed or inhibited. The water content of the Chinese chestnuts can be kept, and a new target and strategy are provided for research and development of a preservative for inhibiting calcification of the Chinese chestnuts after harvesting and improvement of the storage quality and shelf life of the Chinese chestnuts and other horticultural crops after harvesting.

The present application belongs to the field of biological medicine and molecular biology technology, and particularly relates to a marker for predicting the occurrence of repeated implantation failure and application thereof. The present application finds that abnormal lipid peroxidation in uterine epithelium can cause implantation defects, and the lipid peroxidation level of the uterus in patients with repeated implantation failure or repeated spontaneous abortion is enhanced, wherein the content of active aldehyde substance MDA and non-heme iron in serum can be used as a new non-invasive clinical index for predicting RIF patients; further, eliminating uterine lipid ROS to improve endometrial receptivity can be used as a potential new treatment strategy to improve embryo implantation and clinical pregnancy rate, and therefore has good practical application value.

The application provides an engineered probiotic with intracellular chimeric nanoscale enzyme, which is a probiotic modified with several antioxidant enzymes on an inner membrane; the antioxidant enzyme is composed of a metal oxide nanoscale enzyme with a particle size less than 10 nm and a targeting molecular structure and a saccharide molecular structure modified on the surface of the metal oxide nanoscale enzyme; the targeting molecular structure and the saccharide molecular structure are connected to the surface of the metal oxide nanoscale enzyme through a connecting group containing a metal ligand structure based on coordination and electrostatic interaction, and the antioxidant enzyme accounts for 5-20% of the mass of the engineered probiotic. The application also provides a method for preparing the engineered probiotic and application of the engineered probiotic in preparation of a medicine or food for preventing or treating antibiotic-associated diarrhea. The engineered probiotic can realize efficient elimination of hydroxyl radicals near a membrane induced by an antibiotic, so as to accurately inhibit a lipid peroxidation reaction and protect the integrity of a cell membrane.

The invention discloses application of ellagic acid in preparation of a medicine or a biological product for preventing or relieving ultraviolet radiation damage and aging, and belongs to the technical field of biological medicine and radiation protection. Experimental verification shows that ellagic acid with effective concentration can promote expression of antioxidant related genes, reduce expression of inflammation response genes and expression of apoptosis related genes, eliminate active oxygen and inhibit lipid peroxidation reaction, so that oxidative damage, inflammatory reaction and apoptosis caused by ultraviolet radiation are effectively relieved, and the anti-inflammatory effect of ellagic acid is improved. The stress tolerance of an organism is improved, and the aging health risk induced by ultraviolet radiation is relieved; the medicine or biological product can be applied before and / or after exposure of ultraviolet radiation, and is suitable for preventing or relieving oxidative damage and cell aging caused by ultraviolet radiation. The invention provides a new way for developing safe and effective ultraviolet radiation protection and anti-aging preparations.

This invention discloses a pharmaceutical composition for treating asthenospermia by activating the Nrf2 / HO-1 / GPx4 pathway and its application. The pharmaceutical composition comprises taurine and geranium as active ingredients, wherein the mass ratio of taurine to geranium is 3-5:1. The pharmaceutical composition of this invention can synergistically activate the Nrf2 / HO-1 / GPx4 antioxidant signaling pathway, upregulate the expression of downstream antioxidant enzymes GPx4 and HO-1, inhibit lipid peroxidation, protect sperm mitochondrial function, and simultaneously improve the microenvironmental metabolic profile of the epididymis—the site of sperm maturation—thereby enhancing sperm motility. The pharmaceutical composition provided by this invention can be used to prepare a treatment for asthenospermia, particularly oxidative stress-induced asthenospermia.

The present invention discloses a traditional Chinese medicine compound Lactobacillus acidophilus NM probiotic preparation for improving oral bacterial flora and its preparation process, which relates to the related field of biotechnology. The traditional Chinese medicine compound Lactobacillus acidophilus NM probiotic preparation of the present invention combines the synergistic effects of probiotics and traditional Chinese medicine, and has multiple advantages such as regulating oral flora, antibacterial and anti-inflammatory, antioxidant, and relieving fatigue. Lactobacillus acidophilus NM can tolerate acid and bile salts, effectively inhibit pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Salmonella, reduce the occurrence of dental caries, gingivitis, and halitosis. It has no antibiotic resistance and is safer for long-term use. The extracts of Scutellaria baicalensis, honeysuckle, and green tea are rich in flavonoids and tea polyphenols, which can further antibacterial and anti-inflammatory and improve oral health. At the same time, this probiotic can reduce blood lactic acid, blood urea nitrogen, and blood ammonia, enhance the activities of SOD, CAT, and GSH-Px, and inhibit lipid peroxidation, thereby relieving body fatigue and enhancing immunity. The preparation forms are diverse.

The invention provides a 9, 10-dihydrophenanthrene compound and application thereof in liver injury treatment, and particularly provides a compound shown as a formula I or a compound shown as a formula II, which shows anti-inflammatory and antioxidant activity in liver tissues, so that the 9, 10-dihydrophenanthrene compound can be used for treating liver injury diseases, such as liver injury diseases and liver injury diseases. Particularly, the liver injury diseases with inflammation and lipid peroxidation as pathological basis can be treated or prevented. # imgabs0 #

The invention discloses application of ellagic acid in preparation of a medicine for preventing or treating ionizing radiation injury, and belongs to the technical field of biological medicine and radiation protection. Experiments prove that ellagic acid with an effective concentration can inhibit lipid peroxidation, enhance the activity of glutathione transferase and superoxide dismutase and promote the expression of antioxidant related genes such as sod-1, sod-2, gst-1 and gst-29 and immune related genes such as lys-1, irg-1, irg-2 and mul-1, so that the ellagic acid with an effective concentration can inhibit lipid peroxidation and improve the activity of glutathione transferase and superoxide dismutase. Therefore, oxidative damage, inflammatory response, reduced stress tolerance, accelerated aging and shortened service life caused by ionizing radiation exposure are relieved, and the compound can be applied to preparation of drugs for preventing or treating ionizing radiation damage and is suitable for nuclear accident emergency protection, space radiation protection of astronauts and adjuvant therapy of tumor radiotherapy patients. The invention provides a theoretical basis for developing an efficient and low-toxicity ionizing radiation protective agent based on ellagic acid, and has a wide application prospect.

The invention relates to an ion-resistant liposome as well as a preparation method and application thereof, and belongs to the technical field of liposome preparation, and the ion-resistant liposome comprises a water-phase active component, an oil-phase active component and a membrane material. According to the membrane material disclosed by the invention, lecithin and polyglycerol-10 myristate are compounded, so that the interface stability of the lipidosome is synergistically enhanced, and the prepared lipidosome finished product effectively has an outstanding effect of resisting damage of metal ions to the lipidosome structure; in addition, in the water-phase active component and the oil-phase active component, key fruit oil, a caulis polygoni cuspidati seed extract and terminalia bellirica fruit water are combined for use, so that the prepared lipidosome has an excellent anti-oxidation effect through different-dimension synergistic effects of reducing lipid peroxidation, reducing the free radical level and removing various free radicals; the bunge cherry seed extract, the buckeye valeriana seed fat, the samara oil and the roselle flower extract can achieve the synergistic effect of moisturizing and locking water and improving the skin barrier function, so that the prepared liposome has excellent moisturizing and moisturizing effects.

The invention discloses a rosa roxburghii tratt fruit composite beverage with a hangover alleviating effect and a preparation method and application thereof, and belongs to the technical field of biology. The roxburgh rose beverage disclosed by the invention comprises the following raw materials in parts by weight on the basis of 100 parts by weight: 8-16 parts of roxburgh rose concentrated juice, 5-15 parts of crystalline fructose, 0.8-2.5 parts of soybean peptide powder, 0.8-1.8 parts of yeast extract and the balance of water. Experiments prove that the formula product has the advantages of moderate taste, aromatic flavor, good stability and the like, and can keep stable taste and flavor during long-term storage. Animal experiments verify that the roxburgh rose beverage has an obvious hangover alleviating effect by improving ALDH activity, accelerating ethanol metabolism and reducing blood ethanol mass concentration, can improve liver injury caused by drinking by increasing liver SOD, GSH-Px, CAT activity and GSH content, reducing MDA content, enhancing body antioxidant ability and inhibiting lipid peroxidation reaction, and has a liver protection effect.

The embodiment of the invention provides application of hydroxymethoxyphenyl decanone in preparation of a cosmetic composition for preventing squalene in sebum from being oxidized. According to the embodiment of the invention, the hydroxymethoxyphenyl decanone is used as an antioxidant to prepare the cosmetic composition, and when the cosmetic composition is applied to skin, squalene in sebum can be prevented from being oxidized; wherein the hydroxymethoxyphenyl decanone, as an antioxidant, can be used for reducing the peroxide value of squalene in sebum or inhibiting the squalene in the sebum from being oxidized into squalene peroxide products, so that lipid peroxidation of the squalene in the sebum is effectively inhibited or avoided; further, the problems of skin inflammation, hyperpigmentation, scurf and the like caused by squalene peroxide products can be defended and improved.

The invention provides an oligopeptide, and a lentiviral expression vector and a recombinant cell for expressing the oligopeptide. The invention further provides application of the compound in tumor treatment. After the oligopeptide is delivered to HT1080 cells through a lentivirus system, the intracellular SLC7A11 protein level is reduced, the intracellular Fe < 2 + > and lipid peroxidation level is remarkably increased, and the oligopeptide has a remarkable inhibition effect on cell proliferation and has the tumor treatment potential.

The invention discloses a tuberose extract as well as a preparation method and application thereof. The preparation method comprises the following steps: pretreatment; extracting an oil-soluble extract: adding the pretreated dried flower powder into a solvent, heating and extracting; the solvent is a mixture of meadowfoam seed oil and caprylic / capric triglyceride; centrifuging, collecting supernate, filtering and collecting a liquid phase to obtain the tuberose extract. The polianthes tuberosa extract disclosed by the invention has the functions of resisting oxidation, inhibiting cortisol and resisting lipid oxidation, and can efficiently scavenge free radicals at a relatively low concentration, remarkably inhibit lipid peroxidation and help skin to resist oxidative damage; the polianthes tuberosa fat-soluble active ingredients are extracted, the problem of volatile organic solvent residues is avoided, the product safety is guaranteed, and a multifunctional, high-activity and high-safety new raw material is provided for the cosmetic industry.

This invention relates to the field of probiotic screening and application technology, specifically to a Bifidobacterium adolescentis HC2916 that inhibits melanin synthesis, its microbial preparations, and applications. Bifidobacterium adolescentis HC2916 was deposited on May 16, 2023, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 27352. This strain exhibits excellent antioxidant capacity, capable of scavenging various free radicals and inhibiting lipid peroxidation. Furthermore, its fermentation supernatant and lysate significantly downregulate the protein and mRNA expression of MITF, a core factor in melanin production signaling, and inhibit the expression of its downstream key enzymes TYRP1 and TYRP2. This effectively suppresses UVA-induced increases in melanin content in skin keratinocytes, demonstrating promising application prospects in the field of skin whitening.

The invention relates to a tetrahydrocyclopentapyrazole compound which simultaneously has RIPK1 inhibitory activity, free radical scavenging capacity and lipid peroxidation resistance, and application of the tetrahydrocyclopentapyrazole compound in preparation of drugs for treating or preventing RIPK1-mediated diseases or diseases caused by programmed necrosis of cells. Specifically, the invention relates to a compound as shown in a general formula, and pharmaceutically acceptable salt or stereoisomer thereof.

The invention discloses an endoplasmic reticulum targeted lipid peroxidation fluorescent indicator and application thereof, and the indicator introduces a conjugated diolefin structure as a lipid peroxidation recognition unit to obtain a series of BODIPY derivatives with the maximum emission wavelength of 620 nm. A conjugated diene part of the fluorescent probe can be subjected to oxidative cracking under the action of reactive oxygen species, and a conjugated system of the fluorescent probe becomes smaller due to breakage of double bonds, which shows that absorption and emission wavelengths are obviously shortened. Therefore, the LPO process can be monitored through the change of the fluorescence ratio. Meanwhile, hydrophilic succinimide ester sulfonic acid group NHS is introduced as a group reacting with protein, the oil-water coefficient of the compound is moderate, the compound easily penetrates through a cell membrane and reacts with adjacent protein free amino in a short time, the probe can be fixed on the protein of an endoplasmic reticulum through a chemical bond, and the probe can be used for long-time fluorescence imaging research. And long-time real-time tracking is carried out on the movement and form change of the endoplasmic reticulum.

The invention discloses a gas preparation with an anti-hypoxia effect and application of the gas preparation, the gas preparation is obtained by taking normal-pressure air as diluent gas, introducing a small amount of NO and CO2 into the diluent gas to respectively reach corresponding final concentrations, the concentration of the NO is 10-30 ppm, and the concentration of the CO2 is 400-700 ppm. The gas preparation can effectively relieve hypoxia symptoms, and is quick in response, good in effect, wide in applicable crowd and free of side effects. Animal experiments prove that after the NO gas and the CO2 gas are mixed, lipid peroxidation caused by oxidative stress can be inhibited, and the activity of an antioxidant enzyme system of an organism is maintained, so that the NO gas and the CO2 gas are proved to have an anti-hypoxia effect after being mixed.

The invention belongs to the technical field of medicine, and particularly relates to a targeted selenol inhibitor and application thereof. Through metabonomics and transcriptomics analysis, the redox steady state, the metabolic steady state, the cell death mode and the molecular mechanism of the selenol-inhibited glioma cells are researched. Comprising the steps of ROS (reactive oxygen species) generation, GSH / GSSG (glutathione / reduced glutathione) metabolism, lipid peroxidation level and cell death marker detection, the main cell death mode triggered by inhibition of selenol is further identified, and whether molecular events such as endoplasmic reticulum stress and protein misfolding are involved or not is analyzed. Based on the research results, the combined application potential of selenol targeted therapy and existing chemotherapy, radiotherapy and immunotherapy is further evaluated, so that the treatment strategy is optimized, and the treatment response rate of glioma patients is increased.

The invention belongs to the technical field of fungal polysaccharide application, and particularly relates to a yellow-rose yellow-meat boletus polysaccharide as well as a preparation method and application thereof. The preparation method comprises the following steps: extracting crude polysaccharide from boletus rosea sporocarp through a water extraction and alcohol precipitation method, and then carrying out deproteinization, decoloration and DEAE-52 cellulose column chromatography separation and purification to obtain the purified polysaccharide BPP-1 of the boletus rosea water component. CCl4 is selected as an inducer of oxidative stress injury of the MIHA cells to construct a hepatic cell oxidative injury model, and the model is utilized to evaluate the protective effect of BPP-1 on CCl4-induced MIHA cell hepatic injury. The result shows that the BPP-1 reduces the release of ALT and AST, improves the GSH level and the SOD enzyme activity at the same time, inhibits the generation of a lipid peroxidation product MDA, and effectively reduces the damage of CCl4 to liver cells. The results show that BPP-1 has a certain protection effect on CCl4-induced hepatocyte injury, and BPP-1 may be a potential antioxidant and can alleviate oxidative injury of liver.

The invention discloses a composition with a whitening effect. The composition is prepared from the following components in parts by mass: 47 to 51 parts of grape seed oil, 47 to 51 parts of pomegranate seed oil, 0.5 to 0.8 part of 4-butylresorcinol, 0.2 to 0.6 part of VC-IP (Vitamin C-IP) and 0.1 to 10 parts of isorhamnetin-3-O-neohesperidin. The invention also discloses a preparation method of the composition. The invention also discloses an essence oil containing the composition. The invention also discloses a face cream containing the composition. The invention also discloses application of the composition in preparation of cosmetics for skin whitening, spot fading and skin yellowing reduction. The composition provided by the invention establishes a multi-target synergistic pathway: 1, a blackness removal pathway for reducing the activation of oxidative stress such as ultraviolet rays on melanocytes; and 2, a jaundice removal pathway: inhibiting lipid peroxidation and promoting lipofuscin removal.

According to the application, an acute hypoxia animal model is established through a plateau low-pressure oxygen cabin, and the effect of cycloastragenol on prevention of acute hypoxia movement stress mice after pretreatment is evaluated. It is found that cycloastragenol after pretreatment has no adverse effect on the body, the exercise performance of mice can be improved, the exercise time can be prolonged, and gastrocnemius muscle and myocardial tissue damage can be improved. Accumulation of LAC in serum after exhaustive exercise can be remarkably reduced, accumulation of a metabolite BUN is reduced, the activity of antioxidant enzyme T-SOD in the serum is remarkably improved, and accumulation of a lipid peroxidation product MDA in the serum is reduced. The cycloastragenol can reduce the content of inflammatory factors IL-6 and TNF-alpha in serum, improve the level of Ca < 2 + >-Mg < 2 + >-ATP enzyme and Na < + >-K < + >-ATP enzyme in gastrocnemius muscle, regulate energy metabolism and improve energy supply efficiency.

The invention belongs to the technical field of nano material preparation and application, and discloses a method for liquid-phase stripping of iron oxychloride by cysteine and application. The method comprises the following steps: firstly, preparing blocky iron oxychloride through partial thermal decomposition of ferric chloride hexahydrate; and adding L-cysteine into the iron oxychloride solution, and carrying out ultrasonic treatment at 20-40kHz and 10-40 DEG C for 0.5-6 hours to finally prepare the cysteine-iron oxychloride nano material. The average size of the material is 20-200nm, and the material is strip-shaped, is rich in ferrous iron and oxygen vacancies, and has excellent peroxidase-like activity and Fenton reaction activity. The method is green, simple, convenient and low in cost. The prepared nano material can efficiently catalyze and generate active oxygen species such as hydroxyl free radicals, effectively kills drug-resistant escherichia coli and staphylococcus aureus through multiple mechanisms such as initiation of bacterial lipid peroxidation, DNA degradation and protein leakage consumption, shows good biocompatibility in a cytotoxicity test, and can be used for preparing a drug-resistant nano material. Wide application prospects are realized in the field of antibacterial preparations.

The invention belongs to the technical field of antioxidant drugs, and particularly relates to application of a glutathione dry powder inhaler in preparation of drugs for treating radiation acute lung injury, the glutathione dry powder inhaler comprises the following active ingredients by mass percentage: 50%-60% of reduced glutathione, 10%-20% of a carrier and 20%-30% of a dispersant, totaling 100%, the carrier is mannitol, and the dispersing agent is L-leucine. According to the invention, the glutathione dry powder inhalant accurately delivers high-concentration GSH to an alveolar injury area through a lung targeting delivery system, synchronously activates endogenous antioxidant enzymes, inhibits lipid peroxidation and an inflammation source, and blocks release of proinflammatory factors, so that radiation-induced oxidation-inflammation cascade reaction is directly inhibited, alveolar structure damage is relieved, and the anti-inflammatory effect is achieved. And an efficient new treatment strategy is provided for RILI.

The invention belongs to the technical field of medicines, and particularly relates to lactobacillus rhamnosus for relieving acute alcoholic liver injury as well as a metagen and application of the lactobacillus rhamnosus. The lactobacillus rhamnosus L11-4 strain is preserved in the China Center for Type Culture Collection on August 18, 2025, and the preservation number of the lactobacillus rhamnosus L11-4 strain is CCTCC (China Center for Type Culture Collection) NO: M 20251834. The strain and the metagen thereof can significantly improve pathological symptoms of mice with acute alcoholic liver injury, and have the effects of reducing the levels of ALT, AST, TC, TG and LDL-C in serum of the mice with acute alcoholic liver injury, increasing the level of HDL-C, and regulating abnormal blood lipid level of the mice caused by acute alcohol; the activity of antioxidant enzymes in the liver is improved, and the lipid peroxidation level is reduced; in addition, the ethanol dehydrogenase activity of the liver can be improved, and the ethanol metabolism capability is enhanced. Therefore, the strain and the metagen thereof have wide application prospects in prevention or treatment of acute alcoholic liver injury.