16 results about "Lipid peroxidation" patented technology

The antioxidant activity of alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and of alpha-tocopherol succinate (TS) has been examined in isolated hepatocytes and microsomal fractions from rat liver. Both TPGS and TS require esterase activity to yield free alpha-tocopherol and, hence, antioxidant activity. TPGS and TS consistently exerted a more effective antioxidant protection than an equivalent amount of directly-added free alpha-tocopherol. The low antioxidant efficiency of directly added free alpha-tocopherol in such water-based experimental systems as used here seems to be due to its extreme hydrophobicity. TPGS, on the other hand, is an extremely hydrophilic compound which is being examined as a useful source of alpha-tocopherol in certain clinical situations and is here shown to be a convenient and effective source for experimental studies into lipid peroxidation and antioxidant mechanisms.

The application provides an engineered probiotic with intracellular chimeric nanoscale enzyme, which is a probiotic modified with several antioxidant enzymes on an inner membrane; the antioxidant enzyme is composed of a metal oxide nanoscale enzyme with a particle size less than 10 nm and a targeting molecular structure and a saccharide molecular structure modified on the surface of the metal oxide nanoscale enzyme; the targeting molecular structure and the saccharide molecular structure are connected to the surface of the metal oxide nanoscale enzyme through a connecting group containing a metal ligand structure based on coordination and electrostatic interaction, and the antioxidant enzyme accounts for 5-20% of the mass of the engineered probiotic. The application also provides a method for preparing the engineered probiotic and application of the engineered probiotic in preparation of a medicine or food for preventing or treating antibiotic-associated diarrhea. The engineered probiotic can realize efficient elimination of hydroxyl radicals near a membrane induced by an antibiotic, so as to accurately inhibit a lipid peroxidation reaction and protect the integrity of a cell membrane.

This invention discloses a pharmaceutical composition for treating asthenospermia by activating the Nrf2 / HO-1 / GPx4 pathway and its application. The pharmaceutical composition comprises taurine and geranium as active ingredients, wherein the mass ratio of taurine to geranium is 3-5:1. The pharmaceutical composition of this invention can synergistically activate the Nrf2 / HO-1 / GPx4 antioxidant signaling pathway, upregulate the expression of downstream antioxidant enzymes GPx4 and HO-1, inhibit lipid peroxidation, protect sperm mitochondrial function, and simultaneously improve the microenvironmental metabolic profile of the epididymis—the site of sperm maturation—thereby enhancing sperm motility. The pharmaceutical composition provided by this invention can be used to prepare a treatment for asthenospermia, particularly oxidative stress-induced asthenospermia.

This invention relates to the field of probiotic screening and application technology, specifically to a Bifidobacterium adolescentis HC2916 that inhibits melanin synthesis, its microbial preparations, and applications. Bifidobacterium adolescentis HC2916 was deposited on May 16, 2023, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 27352. This strain exhibits excellent antioxidant capacity, capable of scavenging various free radicals and inhibiting lipid peroxidation. Furthermore, its fermentation supernatant and lysate significantly downregulate the protein and mRNA expression of MITF, a core factor in melanin production signaling, and inhibit the expression of its downstream key enzymes TYRP1 and TYRP2. This effectively suppresses UVA-induced increases in melanin content in skin keratinocytes, demonstrating promising application prospects in the field of skin whitening.

This invention discloses an S-estrol composition for delaying ovarian aging and its uses, relating to the fields of biomedicine and health products. The S-estrol composition for delaying ovarian aging comprises, by weight, the following components: 1-5 parts S-estrol, 2-8 parts soy isoflavones, 3-10 parts coenzyme Q10, 2-6 parts vitamin E, 4-12 parts vitamin C, 0.01-0.05 parts folic acid, 0.1-0.3 parts zinc source, 0.5-1.5 parts anti-aging protective agent, 50-80 parts carrier, and 10-15 parts purified water. This invention uses high-purity S-estrol as the core, combined with soy isoflavones, coenzyme Q10 and a variety of antioxidant nutrients in a scientific formulation to form a synergistic system for estrogen receptor signal regulation and antioxidant defense. By constructing a complex antioxidant network and introducing novel anti-aging protectants for synergistic effect, the activity of antioxidant enzymes tends to increase and the level of lipid peroxidation tends to decrease, thereby improving the oxidative stress state in ovarian cells as a whole.

The application relates to a synergistic liquid antioxidant containing chicken-derived active peptides and phospholipids, and relates to the technical field of food additives or health products. The antioxidant comprises the following components in parts by weight: chicken-derived active peptides 2-10%; phospholipids 0.5-5%; stabilizers 0.1-2%; water 60-90%; and the weight ratio of the chicken-derived active peptides to the phospholipids is (2-6):1. By compounding the chicken-derived active peptides and the phospholipids in a specific ratio, the two can form a stable emulsification system and produce a significant antioxidant synergistic effect, effectively eliminating free radicals and inhibiting lipid peroxidation. Meanwhile, the liquid antioxidant has good stability and high bioavailability, can be widely applied in oils, pet foods, oil-containing foods, feed products and cosmetics, and can replace traditional synthetic antioxidants.

This invention discloses a method for improving the environmental stress resistance of fish by subjecting them to intermittent hypoxia training. The method includes: maintaining dissolved oxygen (DO) in the water at normoxic levels; setting a fixed time window daily to begin deoxygenation treatment, causing DO to drop to a target hypoxic level within a specified time and maintaining this target hypoxic level for a period of time; subsequently, reoxygenating to restore DO to normoxic levels. This intermittent hypoxia training is conducted continuously, with water quality indicators maintained within a suitable range for the target fish during the training period. After the training is completed, the resistance of the target fish is evaluated. This invention is simple to operate. After intermittent hypoxia training, the LOE threshold of the target fish decreases under hypoxic stress, and their hypoxia tolerance is improved. The fish also exhibit enhanced antioxidant capacity and reduced lipid peroxidation levels under hypoxic, high-temperature, and high-ammonia nitrogen stress, providing cross-protection for fish populations growing under various environmental stresses.

The application discloses sea cucumber oil and a preparation method and application thereof. The sea cucumber oil is prepared by using sea cucumber intestines as raw materials, and by using 95% ethanol and petroleum ether to soak and extract the sea cucumber oil, and then by using vacuum distillation. By constructing an acute skin ultraviolet radiation damage mouse model, the application verifies for the first time that the sea cucumber oil can effectively relieve the skin redness and keratin layer increase phenomenon caused by ultraviolet radiation, inhibit the ROS rise, reduce the degree of lipid peroxidation of the organism, improve the loss of collagen in the body, regulate the expression of inflammatory factors in the body, up-regulate the expression of the skin Nrf2 gene and the downstream antioxidant gene NQO1, reduce the expression of the negative feedback factor KEAP1, and play an antioxidant role. The sea cucumber oil has high safety, comprehensively and effectively utilizes the waste resources generated in the sea cucumber processing process, and has a good prospect in the cosmetics and medicines for repairing the acute skin light damage after ultraviolet radiation.

The present application discloses a rare ginsenoside composition and its application in anti-fatigue and liver protection, and relates to the technical field of biological medicine. The present application provides a rare ginsenoside composition, which is composed of Rh4, F4 and Dehydroprotopanaxatrial II, and the mass ratio of Rh4, F4 and Dehydroprotopanaxatrial II is (2-4):(2-4):1. The rare ginsenoside composition has the effect of significantly relieving physical fatigue, can reduce the decomposition and metabolism of protein to energy, eliminate fatigue, increase the liver glycogen reserve in the body, improve the fatigue resistance, has the effect of liver protection, enhances the antioxidant defense ability of liver tissue, reduces the lipid peroxidation damage, and improves the lipid metabolism disorder of liver tissue.

The invention belongs to the technical field of biological medicines, and discloses application of artemisinene with double functions in promoting liver cell maturation and relieving liver lipid metabolism dysfunction. It is found for the first time that ATT can specifically and efficiently promote human hepatic progenitor cell organoids to differentiate into functional mature hepatic cells, the effect of ATT depends on activation of a cAMP-EPAC signal channel, and the action mechanism and effect are remarkably different from those of a DHA-based scheme in the prior art. Meanwhile, the ATT can obviously relieve lipid deposition of liver cells, improve lipid metabolism disorder, effectively relieve liver cell oxidative stress and lipid peroxidation damage induced by lipid deposition, and prevent the cells from triggered apoptosis.

This invention belongs to the field of fungal polysaccharide application technology, specifically relating to a method for preparing and applying polysaccharide from *Boletus globosum*. Crude polysaccharide was extracted from the fruiting body of *Boletus globosum* using hot water extraction, and purified using DEAE-52 cellulose column chromatography. Subsequently, by establishing an alcohol-induced liver injury model, it was found that NOP-1 significantly reduced ALT and AST levels, while simultaneously decreasing MDA content and increasing SOD activity and GSH levels, indicating that NOP-1 can inhibit lipid peroxidation, enhance the antioxidant defense capacity of hepatocytes, and maintain hepatocyte membrane integrity. A HepG2 cell IR model was constructed using a high-glucose, high-insulin combined induction method, determining the optimal dosage of NOP-1. ‑6 Treatment of HepG2 cells with mol / L insulin for 24 h successfully induced insulin resistance. Glucose consumption experiments in IR HepG2 cells demonstrated that NOP-1 significantly enhanced the glucose consumption capacity of insulin-resistant cells, exhibiting significant in vitro hypoglycemic activity.

This invention discloses the application of ZBTB7A as a target in the preparation of products for the diagnosis or treatment of sepsis-associated encephalopathy (SAE), belonging to the field of biomedical technology. This invention confirms that ZBTB7A can serve as a diagnostic biomarker and therapeutic target for SAE, providing strong technical support for the early diagnosis and treatment of SAE. Clinical sample validation shows that the expression level of ZBTB7A in peripheral blood astrocyte-derived exosomes of SAE patients is significantly downregulated, enabling early, non-invasive auxiliary diagnosis of SAE with high clinical diagnostic efficacy. This invention clarifies that high expression of ZBTB7A can effectively inhibit the release of pro-inflammatory factors, reduce lipid peroxidation and iron overload, improve the structural and functional integrity of mitochondria, protect neuronal and synaptic structures, and significantly reverse cognitive impairment.

This invention discloses a compound probiotic composition, its preparation method, and its applications. The compound probiotic composition comprises compound probiotics and compound compounds, wherein the components exert a synergistic effect in the body, significantly shortening the righting reflex recovery time after alcohol intake, effectively alleviating the physiological burden caused by alcohol consumption, and reducing alcohol-induced liver oxidative stress and lipid peroxidation levels. In other words, the compound probiotic composition has a hangover-relieving and liver-protecting effect. Furthermore, the compound probiotic composition helps improve and maintain the homeostasis of the gut-liver axis in alcohol- or non-alcohol-related sub-health states (such as sleep disorders), improving liver damage, regulating gut microbiota structure, and improving intestinal barrier damage. It is suitable for individuals requiring liver function regulation and nutritional intervention.

This invention belongs to the field of cosmetic technology, specifically relating to a composition with anti-ultraviolet protection for hair and its application. It includes extracts of coltsfoot flower, sisal extract, raspberry ketone glucoside, and camellia flower extract, with a weight ratio of (1-3):(1-3):(2-5):(2-6). The composition provided by this invention, through the synergistic effect of its components, can effectively absorb UVA / UVB ultraviolet rays, reducing damage to the hair cuticle and cortex caused by ultraviolet radiation; it also has excellent antioxidant capacity, scavenging free radicals generated by ultraviolet radiation, delaying keratin degradation and lipid peroxidation; and it can stabilize melanin, preventing hair color fading. This composition can significantly reduce problems such as increased hair combing resistance and cuticle lifting caused by ultraviolet radiation.

This invention, entitled "Application of Bifidobacterium animalis subsp. lactis BL-16 and its Astragalus ferment and anti-aging products," belongs to the field of microbial technology. The technical problem to be solved is to provide an anti-aging Bifidobacterium animalis subsp. lactis and its BL-16 fermented Astragalus extract. The key technical point is the application of Bifidobacterium animalis subsp. lactis BL-16 or its fermented Astragalus extract in the preparation of anti-aging compositions. Bifidobacterium animalis subsp. lactis BL-16 and its fermented Astragalus extract can scavenge free radicals in vivo and in vitro and enhance anti-lipid peroxidation capacity, exhibiting good antioxidant and immunomodulatory effects. They can effectively improve survival rate, motility, and reproductive capacity, thus having a good effect on delaying aging.

This invention relates to an aromatic deodorizing composition, its preparation method, and its application, belonging to the technical field of daily chemical products. The invention provides an aromatic deodorizing composition, comprising, by weight percentage, 0.1-0.7 wt% of plant-derived active monomers and 0.05-6 wt% of a stationary phase, wherein the stationary phase comprises zinc gluconate and pyrrolidone carboxylic acid. This invention, by combining a stationary phase containing zinc gluconate and pyrrolidone carboxylic acid with plant-derived active monomers to form an aromatic deodorizing composition, purposefully reduces odor molecules (isovaleric acid, ammonia, trimethylamine, hydrogen sulfide), inhibits Escherichia coli and lipid peroxidation, thereby achieving the effect of aromatic deodorization and odor removal.