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On long-term hypoxic stress, there is an energy deprivation in tumor cell which results in elevated AMP/ATP ratio, leading to the activation of AMPK, a major regulator of cellular energy homeostasis. Hypoxic stress and IL-7 gene overexpression enhance the fusion potential of rat bone marrow mesenchymal stem cells with bovine renal epithelial cells.
A method for improving the ability of fish to resist environmental stress
This invention discloses a method for improving the environmental stress resistance of fish by subjecting them to intermittent hypoxia training. The method includes: maintaining dissolved oxygen (DO) in the water at normoxic levels; setting a fixed time window daily to begin deoxygenation treatment, causing DO to drop to a target hypoxic level within a specified time and maintaining this target hypoxic level for a period of time; subsequently, reoxygenating to restore DO to normoxic levels. This intermittent hypoxia training is conducted continuously, with water quality indicators maintained within a suitable range for the target fish during the training period. After the training is completed, the resistance of the target fish is evaluated. This invention is simple to operate. After intermittent hypoxia training, the LOE threshold of the target fish decreases under hypoxic stress, and their hypoxia tolerance is improved. The fish also exhibit enhanced antioxidant capacity and reduced lipid peroxidation levels under hypoxic, high-temperature, and high-ammonia nitrogen stress, providing cross-protection for fish populations growing under various environmental stresses.
Owner:SICHUAN AGRI UNIV