Use of miRNA708, and/or 301 cluster microRNAs in improving cardiac function

A tiny, useful technology, applied in medical preparations containing active ingredients, pharmaceutical formulations, cardiovascular system diseases, etc., can solve problems such as hindering the development of stem cell therapy

Active Publication Date: 2022-02-18
SHANGHAI EAST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although stem cell research provides a new and promising approach for heart regeneration, clinical trials transplant exogenous stem cells into damaged hearts, the number of cells retained in the heart, and how to induce the transplanted stem cells to differentiate in the recipient For cardiomyocytes, as well as the functional integration of newly differentiated cardiomyocytes and endogenous cardiomyocytes, are real great challenges that hinder the development of stem cell-based therapies.

Method used

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  • Use of miRNA708, and/or 301 cluster microRNAs in improving cardiac function
  • Use of miRNA708, and/or 301 cluster microRNAs in improving cardiac function
  • Use of miRNA708, and/or 301 cluster microRNAs in improving cardiac function

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Embodiment Construction

[0107] After extensive and in-depth research, and through a large number of screenings, the present inventor unexpectedly found for the first time that the microRNAs of miRNA708 and 301 clusters can (i) promote the proliferation of cardiomyocytes; (ii) improve the ability of cardiomyocytes to resist hypoxia; (iii) ) reducing apoptosis and death of cardiomyocytes; (iv) inducing proliferation and differentiation of cardiac stem cells; and / or (v) protecting cardiomyocytes from hypoxic stimulation. On this basis, the inventors have completed the present invention.

[0108] miRNA301, 708 cluster

[0109]miRNA301 and cluster 708 microRNAs are single-stranded RNAs with a length of only 23 bases, which are conserved in mammalian sequences. It has been reported in the literature that both are related to the occurrence and regulation of cancer, and miRNA301 is also related to immune function. However, the regulatory relationship between miRNA301 and 708 cluster microRNAs and heart dev...

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Abstract

The present invention provides the application of miRNA708 and / or microRNA of cluster 301 in improving heart function. Specifically, microRNAs of miRNA708 and / or 301 clusters can (i) promote cardiomyocyte proliferation; (ii) improve cardiomyocyte anti-hypoxic stress ability; (iii) reduce cardiomyocyte apoptosis and death; (iv) induce myocardial cell proliferation; Proliferation and differentiation of stem cells; and / or (v) protecting cardiomyocytes from hypoxic stimulation.

Description

technical field [0001] The invention belongs to the field of heart treatment. Specifically, the application of miRNA708 and / or microRNAs of cluster 301 in improving heart function. Background technique [0002] In mammalian heart development, cardiomyocytes undergo a transition from rapid hyperplasia to hypertrophy before birth. Shortly after birth, the cell cycle of cardiomyocytes terminates and becomes so-called terminally differentiated cells, so the heart has been considered a terminally differentiated organ. The proliferation of cardiomyocytes in mammalian adult heart is stagnant and adult cardiac stem cells are also in a quiescent period. Therefore, after pathological damage to the heart, cardiomyocytes are almost unable to regenerate and their function is difficult to recover. Emerging evidence shows that cardiomyocytes still have a very low rate of reversal during normal aging, and that the adult heart has a certain regenerative potential, especially under certain ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/7088A61P9/00A61P9/10
CPCA61K45/00A61K31/7088
Inventor 俞作仁邓生琼甄丽晓赵倩
Owner SHANGHAI EAST HOSPITAL
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