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5 results about "Cardiomyocyte proliferation" patented technology
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Myocardial function is compromised in several forms of heart disease due to the loss of cardiomyocytes and in part to the limited ability of surviving myocytes to re-enter the cell cycle. The ability to induce cardiomyocyte proliferation will improve myocardial function.
Application of Mybl2 protein in preparation of medicine for repairing heart injury
The invention provides application of Mybl2 protein in preparation of a medicine for repairing heart injury, and belongs to the technical field of biological medicine. The invention provides an application of Mybl2 protein in preparation of a medicine for repairing heart injury. The medicine comprises overexpressed Mybl2 protein. Mybl2 overexpression can significantly increase the proportion of myocardial cell proliferation and promote expression of cell cycle related proteins, Mybl2 participates in maintaining the proliferation capacity of myocardial cells, and overexpression can effectively promote myocardial cell proliferation and is a potential new target for myocardial regeneration.
Owner:SECOND AFFILIATED HOSPITAL OF HAINAN MEDICAL UNIVERSITY +1
Method of inducing cardiomyocytes proliferation and treating heart diseases
ActiveUS12576191B2Peptide/protein ingredientsSkeletal/connective tissue cellsDiseaseHeart Muscle Cell
An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.
Owner:YEDA RES & DEV CO LTD
Method of inducing cardiomyocytes proliferation and treating heart diseases
PendingUS20260174935A1Peptide/protein ingredientsSkeletal/connective tissue cellsDiseaseHeart Muscle Cell
An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.
Owner:YEDA RES & DEV CO LTD
Oxygen-producing hydrogel for myocardial repair and preparation method thereof
This invention belongs to the technical field of hydrogel materials for myocardial repair, specifically relating to an oxygen-generating hydrogel for myocardial repair and its preparation method. The invention involves modifying GelMA with KH570 in PBS buffer to prepare KH570-GelMA, and oxidizing cobalt chloride, strontium chloride, sodium hydroxide, and sodium hypochlorite in aqueous solution to prepare CoOOH-Sr nanosheets. The CoOOH-Sr nanosheets are then mixed with the KH570-GelMA solution and a photoinitiator is introduced for in-situ curing to prepare the oxygen-generating hydrogel. By modifying GelMA with KH570, the crosslinking density is controlled, increasing the hydrogel porosity. The introduction of CoOOH-Sr functional molecules enables controlled oxygen production, alleviating local hypoxia, improving the cell compatibility and bioactivity of the hydrogel, promoting cardiomyocyte proliferation and tissue regeneration, and allowing for the construction of injectable or patch-like hydrogel patches suitable for myocardial infarction models.
Owner:SOUTHERN MEDICAL UNIVERSITY
Use of heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases
Provided herein is the use of heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases. Specifically, disclosed is the use of compounds of formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a prodrug thereof; and application thereof. Definition of each group in the formula can be found in the specification for details.
Owner:SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE