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4 results about "Agrin" patented technology
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Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene.
Biomarkers for hypoxic-ischemic encephalopathy, and diagnostic methods using thereof
The invention relates to the proteins Agrin, Zyxin, Synaptotagmin-5, and combinations thereof, as well as the gene transcripts form the corresponding genes, as biomarkers of a hypoxic-ischemic encephalopathy (HIE).
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES +3
Method of inducing cardiomyocytes proliferation and treating heart diseases
ActiveUS12576191B2Peptide/protein ingredientsSkeletal/connective tissue cellsDiseaseHeart Muscle Cell
An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.
Owner:YEDA RES & DEV CO LTD
Method of inducing cardiomyocytes proliferation and treating heart diseases
PendingUS20260174935A1Peptide/protein ingredientsSkeletal/connective tissue cellsDiseaseHeart Muscle Cell
An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.
Owner:YEDA RES & DEV CO LTD
Agrin monoclonal antibodies and uses thereof
This invention provides a monoclonal antibody against the Agrin protein and its applications, belonging to the field of immunoassay technology. The monoclonal antibody is secreted by a hybridoma cell line with accession number CCTCC NO: C2025396 and specifically recognizes a key epitope in the Z8 region of the human Agrin protein. Based on this monoclonal antibody and / or the Agrin Z8 peptide, this invention constructs a kit for detecting anti-Agrin Z8 antibodies in the serum of patients with myasthenia gravis. The Agrin monoclonal antibody is used as a positive control or quantitative standard in this kit. Furthermore, this Agrin monoclonal antibody can be used to construct animal models of myasthenia gravis to study the pathogenesis of the disease. The Agrin monoclonal antibody provided by this invention has high specificity and high affinity, providing a key tool for the standardized diagnosis of myasthenia gravis and an effective means for studying its pathogenesis.
Owner:FU JIAN YI KE DA XUE FU SHU DI ER YI YUAN