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9 results about "Sonic hedgehog" patented technology
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Sonic hedgehog is a secreted protein that in humans is encoded by the SHH gene. It is the best studied ligand of the hedgehog signaling pathway, others being desert hedgehog (DHH) and Indian hedgehog (IHH). It plays a key role in the development of animals, from insects to mammals. In vertebrates, it is involved in organogenesis, including the growth of digits on limbs and the organization of the brain. Sonic hedgehog is an archetypal example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. Sonic hedgehog is also active in adults; for example, it controls the proliferation of adult stem cells and has been implicated in the development of some cancers.
Method for producing cell mass including pituitary tissue, and cell mass thereof
The present invention aims to provide a method for efficiently producing a cell mass containing pituitary tissue from pluripotent stem cells. A method for producing a cell mass containing pituitary tissue, including the following steps (1) and (2):(1) a first step of suspension-culturing pluripotent stem cells to form a cell aggregate in the presence of a Wnt signal transduction pathway inhibiting substance,(2) a second step of suspension-culturing the aggregate obtained in the first step in the presence of a BMP signal transduction pathway activating substance and a Sonic hedgehog signal transduction pathway activating substance, thereby obtaining a cell mass comprising pituitary tissue.
Owner:SUMITOMO CHEM CO LTD
Production method for nerve tissue
The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3):(1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGFβ family signal transduction pathway inhibiting substance and / or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state,(2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and(3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.
Owner:RACTHERA CO LTD +1
Spinal cord organoid and method for producing same
PCT designated stageWO2026049008A1Nervous disorderMicrobiological testing/measurementPluripotential stem cellRetinoic acid receptor
Provided are: a method for producing a spinal cord organoid from a pluripotent stem cell in vitro, the method comprising (1) a step for culturing a human pluripotent stem cell in a culture medium that contains a ROCK inhibitor and a Wnt signal activator but does not substantially contain a TGFβ inhibitor or a BMP signal inhibitor, (2) a step for further culturing the cell obtained in step (1) in a culture medium that contains a retinoic acid receptor agonist and a hedgehog signal activator, and (3) a step for further culturing the cell obtained in step (2) in a culture medium that does not substantially contain a TGFβ inhibitor, a BMP signal inhibitor, a retinoic acid receptor agonist, or a sonic hedgehog stimulator to obtain a spinal cord organoid; and a spinal cord organoid obtained by the method. The spinal cord organoid according to the present application comprises at least a portion of the dorsal side of the spinal cord and a ventral region of the spinal cord.
Owner:OTSUKA PHARM CO LTD +1
Method for producing retinal tissue and retina-related cells
The present invention provides a method for producing a retinal progenitor cell, including (1) a first step of subjecting pluripotent stem cells to floating culture in a serum-free medium to form an aggregate of pluripotent stem cells, and (2) a second step of subjecting the aggregate formed in step (1) to floating culture in a serum-free medium or serum-containing medium each being free of a substance acting on the Sonic hedgehog signal transduction pathway but containing a substance acting on the BMP signal transduction pathway, thereby obtaining an aggregate containing retinal progenitor cells.
Owner:SUMITOMO CHEM CO LTD +1
Compound for inhibiting proliferation of Sonic Hedgehog type myeloblastoma and promoting differentiation and application thereof
The invention discloses a compound for inhibiting proliferation of Sonic Hedgehog type myeloblastoma and promoting differentiation and application of the compound, and belongs to the technical field of biological medicine. The neuron inducer is obtained through screening, the molecular formula of the neuron inducer is C27H21ClN2O3, the CAS Number is 937807-66-4, and the compound can remarkably up-regulate mRNA and protein expression of NeuroD1 in tumor cells, promote differentiation of medulloblastoma towards neurons and inhibit malignant proliferation, so that growth and diffusion of tumors are inhibited fundamentally, the treatment effect of low toxicity and high efficiency is shown, and the neuron inducer has a good application prospect. Therefore, the compound has important development and application values in clinical treatment of the myeloblastoma, and the compound can be used for preparing the medicine for treating the myeloblastoma by trying to prepare the medicine for treating the myeloblastoma.
Owner:FUDAN UNIV SHANGHAI CANCER CENT +1
Method for producing dopaminergic neuron progenitor cell
PendingUS20260176580A1Culture processNervous system cellsCell-Extracellular MatrixDifferentiation-inducing factor
A cell population comprising Corin- and / or Lrtm1-positive cells was produced by the following steps (1) and (2), from which Corin positive and / or Lrtm1 positive cells are collected using a substance that binds to Corin and / or a substance that binds to Lrtm1, and dopaminergic neuron progenitor cells are produced by performing suspension culture of the Corin positive and / or Lrtm1 positive cells in a culture solution containing one or more nutritional factors:(1) a step of performing adhesion culture of pluripotent stem cells in a medium for maintaining undifferentiated state containing a Sonic hedgehog (SHH) signal stimulant, and an undifferentiated state-maintaining factor in the absence of feeder cells but in the presence of an extracellular matrix, and(2) a step of culturing the cell population obtained in the step (1) in a culture solution containing one or more differentiation-inducing factors.
Owner:KYOTO UNIV +1
Method for producing extracellular vesicles containing bioactive substance
PendingUS20260007609A1Peptide/protein ingredientsSkeletal/connective tissue cellsExtracellular vesicleCellular secretion
It is an object of the present invention to provide a method for efficiently producing extracellular vesicles containing biologically active materials such as sonic hedgehog (Shh). The present invention provides, as a solution, a method for producing extracellular vesicles, comprising obtaining extracellular vesicles secreted from cells subjected to a treatment of inactivating Rab GTPase such as Rab18, wherein the cells are preferably cells expressing Shh. In addition, the present invention provides, as a solution, an extracellular vesicle containing Shh and having a particle diameter of 800 nm or more and / or a volume of 109 nm3 or more.
Owner:THE UNIV OF TOKYO
Running shoes (sonic hedgehog awakening 2.1)
1. Name of the product in this design: Running Shoes (Sonic Cat Awakening 2.1). 2. Purpose of this design: Running shoes for wearing. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.
Owner:GUANGZHOU SONIC CAT SPORTS DEVELOPMENT CO LTD
Method for producing cell mass including pituitary tissue, and cell mass thereof
PendingUS20260034178A1Nervous system cellsSkeletal/connective tissue cellsCell massSuspension culture
The present invention aims to provide a method for efficiently producing a cell mass containing pituitary tissue from pluripotent stem cells. A method for producing a cell mass containing pituitary tissue, including the following steps (1) and (2):(1) a first step of suspension-culturing pluripotent stem cells to form a cell aggregate in the presence of a Wnt signal transduction pathway inhibiting substance,(2) a second step of suspension-culturing the aggregate obtained in the first step in the presence of a BMP signal transduction pathway activating substance and a Sonic hedgehog signal transduction pathway activating substance, thereby obtaining a cell mass comprising pituitary tissue.
Owner:SUMITOMO CHEM CO LTD