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81 results about "Surface marker" patented technology
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Guangdong small-ear spotted pig spermatogonial stem cell in-vitro culture system construction and surface marker screening
The invention discloses construction of a Guangdong small-ear spotted pig spermatogonial stem cell in-vitro culture system and screening of surface markers, and belongs to the technical field of cell culture.The technical scheme includes that testis are broken firstly, then enzyme digestion, density gradient centrifugal purification and differential adherent purification are conducted, and purified spermatogonial stem cells are obtained; inoculating the obtained spermatogonial stem cells to feeder layer cells and culturing in a culture medium; the culture medium is a DMEM culture medium added with FBS and growth factors; the mass fraction of the FBS in the DMEM culture medium is 8-12%, an enzyme digestion method, a density gradient centrifugation method and a differential adhesion method are combined for application, the Guangdong small-ear spotted pig spermatogonia stem cells with certain purity are obtained, cells enriched and purified in vitro can proliferate massively, and an in-vitro culture system of the Guangdong small-ear spotted pig spermatogonia stem cells is established.
Owner:ANIMAL SCI RES INST GUANGDONG ACADEMY OF AGRI SCI
Methods, apparatus, equipment, and media for modifying dates on glass-printed trademarks.
This invention discloses a method, apparatus, device, and medium for modifying the date on printed glass trademarks, relating to the field of surface marking on glass products. The method includes the following steps: acquiring a digital pattern of the glass trademark to be modified, and automatically parsing the original date information and its corresponding encoding rules in the pattern using a pre-set date encoding rule library; receiving a target date input, and calculating the graphic representation difference between the original date information and the target date based on the parsed encoding rules, including graphic element areas that need to be removed or added during printing; and visually marking the calculated graphic element areas to be removed using a specific marker color on an overlay layer independent of the original pattern layer, wherein the specific marker color is distinguishable from the ink color used in printing. This invention offers advantages such as high efficiency and accuracy, non-destructive editing, rule-driven operation, flexible adaptation, integrated workflow, and reduced long-term costs.
Owner:YINGHUI (DACHANG) AUTOMATION & TECH CO LTD +1
Surface marker modification of fibroblasts to target cells to specific tissue and organs for therapeutic use
PCT designated stageWO2026085031A3Genetically modified cellsGenetic material ingredientsSurface markerMedicine
The present disclosure concerns genetic modification of fibroblasts or fibroblast-derived materials (including of the fibroblasts from which the fibroblast-derived materials are derived). In specific aspects, they are modified such that they may express one or more surface markers that allow targeting to a tissue and / or organ of interest. In some aspects, they are modified such that they may lose one or more surface markers that then allow targeting to a tissue and / or organ of interest. In certain aspects, one or more surface markers are modified that then allows targeting to a tissue and / or organ of interest.
Owner:FIBROBIOLOGICS INC
Position encoder calibration method and system for print substrate printing
The application discloses a position encoder calibration method and system for printing of a printing substrate, the method comprising: setting a plurality of reference distance intervals divided by a plurality of photoelectric detectors on a conveying path of the printing substrate; in response to a first photoelectric detector being triggered by a front end edge of the printing substrate, clearing the encoder and printing based on the first photoelectric detector; in response to a subsequent photoelectric detector being triggered by the front end edge of the printing substrate, obtaining a cumulative count value of the encoder and calculating a position error of a previous interval; during the printing substrate passing through the current interval, converting the position error into a number of compensation pulses and inserting or skipping a corresponding number of count cells in an expected natural count sequence of the encoder to complete compensation. The application effectively eliminates the accumulated deviation caused by long-distance conveying of a large-size printing substrate by segmenting the measurement error and uniformly distributing the pulses in the next interval for compensation, and realizes high-precision printing without surface marking.
Owner:SHANGHAI RONGYUE ELECTRONIC TECH CO LTD
Organ-like culture medium, kit and method for culturing organ-like
The invention discloses an organoid culture medium, a kit and a method for culturing an organoid, and relates to the technical field of organoid culture. The organoid culture medium provided by the invention can improve the proliferation activity of the organoid, a relatively complete organoid form can be obtained through culture, and the cost of the culture medium is reduced. The tumor cell organoid obtained by adopting the organoid culture medium provided by the invention has a more complete tumor cell surface marker, and the cell damage is smaller.
Owner:JETLIFE TECHNOLOGY (HANGZHOU) CO LTD
Miniature air compressor interface mounting and surface marking integrated apparatus and method
The present application relates to a kind of micro air compressor interface installation and surface marking integrated equipment and method, belong to air compressor auxiliary production equipment field.Structure light detection and transmission module is vertically connected with large rack and fixed on ground, and unqualified product removal module is vertically and closely connected with conveying belt;Micro air compressor transport module is fixed on the large platform of rack shell, and torsion gun movement mechanism is fixed on the large platform, and torsion gun adjustment module is fixedly connected with torsion gun movement mechanism;Interface pickup module is fixed on the frame of shell by pin shaft, surface marking mechanism is fixed on the large platform, and rack shell is fixed on ground;Automatic unloading mechanism is fixed by magnetic attraction device of rack shell and rack shell.The advantages are that the equipment integrates feeding, detection, installation, waste removal and product collection, saves a lot of production time and human resources, reduces the increase rate of misdelivery, miswaste or unqualified products caused by manual detection and installation, and greatly improves production efficiency.
Owner:JILIN UNIVERSITY
Methods for isolating surface marker displaying agents
ActiveUS12631624B2Microbiological testing/measurementDNA preparationSurface markerBiomedical engineering
The invention relates to method and kits for highly specific isolation of surface marker displaying agents by targeting at least two surface markers. The invention further relates to methods and kits for analyzing surface marker displaying agents and their contents.
Owner:MESO SCALE TECH LLC
Large space tracking using a wearable optics device
ActiveUS12645289B2Image enhancementInput/output for user-computer interactionSurface markerComputer graphics (images)
Systems and methods for determining a head pose of a user are described. Images captured by a head-mounted camera worn by the user are received, the images comprising captured markers, wherein each captured marker is one of a plurality of markers on a surface that are in the FOV of the head-mounted camera. Stored markers having a predetermined orientation and corresponding to each captured marker are identified from a database, the stored markers comprising coordinates for its corresponding surface marker. An orientation of the captured marker relative to its corresponding stored marker is calculated and the stored marker is obtained. Based on the stored marker and the orientation, an absolute pose of each marker is determined. Based on the absolute pose of each marker, the head pose of the user relative to the surface is calculated.
Owner:BAE SYSTEMS PLC
A method for surveying and analyzing karst collapse geological disasters
This invention discloses a method for the exploration and analysis of karst collapse geological hazards, specifically relating to the field of geological hazard exploration and analysis. The method includes: after collecting current and historical images of a target area on a cloud-based collaborative platform, performing image pairing based on shooting location, shooting orientation, and coverage boundaries; dividing the overlapping areas of each image pair into land tables; and outputting image pairs and land table sequences. For land tables with the same sequence number in each image pair, extracting the boundaries of open water, wet soil, bare soil, vegetation, and shadow, and writing a single land surface marker based on the first digit of the enclosed area. This invention addresses the problem in existing technologies where inconsistent surface conditions between different exploration images are easily misjudged as collapse evolution changes by performing image pairing, land table division, single land surface marker generation, non-comparable grid re-sampling and backfilling, and comparable grid segment change determination.
Owner:山东省地质矿产勘查开发局第四地质大队
Organ-like element for simulating dormancy and recurrence process of breast cancer cells and construction method and application of organ-like element
The invention provides an organoid for simulating a dormancy and recurrence process of breast cancer cells as well as a construction method and application of the organoid. The construction method comprises the following steps: culturing breast cancer cells, and carrying out flow sorting on surface markers CD44 and ITGB4 to obtain an ITGB4 low-expression (ITGB4low) cell population; packaging a lentiviral vector, infecting a cell population with low expression of ITGB4, and carrying out flow sorting to obtain a stably transfected cell population; and carrying out induction treatment on the stably transfected cell population and culturing to obtain the organoid. The organoid provided by the invention provides powerful support for prevention and / or treatment of metastatic breast cancer, and shows extraordinary application prospects in accurate and efficient screening of drugs for targeting dormancy-recurrence process.
Owner:INST OF ZOOLOGY CHINESE ACAD OF SCI +1
Otic progenitor cell surface markers
The present invention relates to a cell population of spiral ganglion neural progenitors (SGNPs) and methods how to isolate these cells from an in-vitro mixed cell population. The cell population expresses one or more markers, wherein the one or more marker is CXCR4, SUSD2, LPAR3, EPHA5, CHRNA3, REEP1, NPFFR2, SORCS3, NFASC, GABRB3, KCNB2, GRM8, DLL3, and / or KCNH8.
Owner:WDI 2 APS
Methods for combinatorial immunosequencing
PCT designated stageWO2026096946A2Microbiological testing/measurementDisease diagnosisSurface markerAssay
The disclosure relates to methods, compositions, and kits for detecting and analyzing surface marker displaying agents (SMDAs). The disclosure further relates to methods for detecting, diagnosing, monitoring response to treatment or recurrence, or predicting overall survival, progression-free survival or duration of response in a subject suspected of having colorectal cancer (CRC) comprising performing one or more assays on at least one biological sample from the subject to detect one or more specific populations of EVs.
Owner:MESO SCALE TECH LLC
Exosome detection method based on double-hairpin nucleic acid probe assembly
PendingCN121826174AMicrobiological testing/measurementMaterial analysisSurface markerNucleic Acid Probes
The invention discloses an exosome detection method based on double-hairpin nucleic acid probe assembly, and belongs to the technical field of exosome detection. The exosome detection method comprises the following steps: step 1, constructing a multi-element hairpin probe H1; step 2, constructing a multi-element hairpin probe H2; 3, preparing a probe; 4, multi-element signal probes are assembled, in the step 4, three groups of H1 probes and H2 probes are arranged in total, the proportion of the first group of H1 probes and 400 nM H2 probes is 80 nM, the proportion of the second group of H1 probes and 300 nM H2 probes is 80 nM, and the proportion of the third group of H1 probes and 350 nM H2 probes is 80 nM; according to the exosome detection method based on double-hairpin nucleic acid probe assembly, parallel detection of different exosome surface markers can be achieved by constructing multiple hairpin probes H1 and H2, and meanwhile the requirements for high specificity and stability are met.
Owner:SHENZHEN DONGYI MEDICAL LAB
Toy Vehicle
A toy vehicle is disclosed that integrates customizable surface markings, removable accessories, and functional storage for drawing instruments. The vehicle includes a main body formed of a smooth, erasable substrate configured to receive and release markings from marking instruments. The marking instruments are dual-purpose, allowing users to draw directly on designated surface regions of the vehicle and to be stowed in integrated compartments that visually mimic functional automotive elements such as headlights, taillights, and exhaust ports. The vehicle further includes removable charms and stylized figures attachable to predefined locations. Internal storage compartments retain accessories when not in use. An embedded drive assembly, power system, and remote-control interface enable electronic actuation, while integrated decorative stickers and modular mounting zones allow for extensive personalization.
Owner:MERCHSOURCE LLC
Miniature air compressor interface mounting and surface marking integrated equipment and method
The invention relates to a miniature air compressor interface mounting and surface marking integrated device and method, and belongs to the field of air compressor auxiliary production equipment. The structured light detecting and conveying module is vertically butted with the large rack and is fixed on the ground; the unqualified product removing module is vertically clung to and butted with the conveying belt; the miniature air compressor conveying module is fixed to a large platform of the machine frame shell, the torsion gun movement mechanism is fixed to the large platform, and the torsion gun adjusting module is fixedly connected with the torsion gun movement mechanism. The interface pickup module is fixed on a frame body of the shell through a pin shaft, the surface marking mechanism is fixed on a large platform, and the frame shell is fixed on the ground; the automatic discharging mechanism is fixed to the machine frame shell through a magnetic attraction device of the machine frame shell. The device has the advantages that the device integrates feeding, detecting, installing, waste removing and finished product collecting, a large amount of manpower resources of production time are saved, the mistaken collection and waste or the increase rate of unqualified products caused by manual detecting and installing are reduced, and the production efficiency is greatly improved.
Owner:JILIN UNIVERSITY
Infusion volume detection system and method
A vision-enabled fluid flow rate detection system is disclosed. The system includes an image sensing device that images an infusion container supplying a fluid to an infusion pump and a pattern of markings associated with a surface of the container, and identifies a visual difference in the pattern from a default state of the pattern to determine a volume of fluid infused from the infusion container, and used to calculate a volume of fluid in the container and a flow rate of the fluid. When the amount of fluid, as determined by the vision system, differs from the amount reported by the pump, the pump's motor may be adjusted to correct the expected volume or flow rate, as needed. When a severe infusion inaccuracy is detected, an alarm or other indication may be provided, or the infusion terminated.
Owner:CAREFUSION 303 INC
Marking graphic structure
Owner:NEXCHIP SEMICON CO LTD
Screening method of induced pluripotent stem cell clone
PendingCN121699878APreparing sample for investigationForeign genetic material cellsSurface markerVitamin C
The invention relates to the technical field of biomedicine, in particular to a screening method for induced pluripotent stem cell cloning. The method comprises the following steps: before subsequent operation of cloning, enabling cells to be in a pretreatment culture condition containing vitamin C; performing surface marker detection on the pre-treated suspected induced pluripotent stem cell clones, and performing spatial positioning according to the surface marker detection; performing chelating agent warm dissociation on the localized clones to separate the target clones; the clones are transferred to a new culture condition and cultured in the presence of an Rho kinase inhibitor. Vitamin C is introduced for pretreatment before a traditional cloning and screening process, so that the induced pluripotent stem cells obtain higher morphological integrity and stress tolerance before being subjected to high stress steps such as dyeing, positioning and dissociation.
Owner:SICHUAN HEXAO CELL BIOTECHNOLOGY CO LTD
Method for estimating the rate of senescent immune cells
The objective is to provide a simple and indirect method for estimating the rate of senescent immune cells (the ratio of immune cells with high SAβgal expression levels among T cells whose surface marker is CD8-positive) using a small amount of blood sample. [Solution] This method estimates the rate of senescent immune cells using the relative expression levels of one or more selected from Granzyme K, α-Klotho, GDF15, PAI-1 (SERPIN1), and ferritin in the blood.
Owner:FUAN KERU
CT (Computed Tomography)-guided needle biopsy body surface calibrator
The CT-guided needle biopsy body surface calibrator comprises a calibration ruler and a catheter, the calibration ruler comprises two supporting strips which are arranged in parallel and are made of plastic materials, and a plurality of metal rods which are arranged between the two supporting strips at equal intervals; wherein the middle part of one or more metal rods is movably connected with an angle regulator, and the catheter is arranged on the angle regulator and is used for guiding the puncture needle. According to the puncture calibrator, the smoothness and success rate of puncture operation can be improved, the calibrator can be repeatedly used, the equipment cost is lower, and the puncture calibrator is worthy of being vigorously popularized.
Owner:WENZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Systems and methods for extracting surface markers for aircraft navigation
A method comprises capturing, with a vehicle vision sensor, a color image of a landing site including landing surface markers; converting the color image to a gray scale image; and performing multi-scale-binarization to detect multiple edges of the gray scale image and produce binary images. The method determines contours of edges of the binary images having closed shapes, detects closed shapes of contours of edges having four corners, and verifies whether four-sided candidate contours are valid as potential landing surface markers. If more than one contour is associated with a valid ID within a surface marker library, then the contour within the smallest window size is selected. If multiple contours with the same window size can be associated with a valid ID, then a mean of corresponding corners of multiple contours is computed. The method then performs corner refinement of valid four-sided candidate contours identified as potential landing surface markers.
Owner:HONEYWELL INTERNATIONAL INC
Methods for combinatorial immunosequencing
PCT designated stageWO2026096946A3Microbiological testing/measurementDisease diagnosisSurface markerAssay
The disclosure relates to methods, compositions, and kits for detecting and analyzing surface marker displaying agents (SMDAs). The disclosure further relates to methods for detecting, diagnosing, monitoring response to treatment or recurrence, or predicting overall survival, progression-free survival or duration of response in a subject suspected of having colorectal cancer (CRC) comprising performing one or more assays on at least one biological sample from the subject to detect one or more specific populations of EVs.
Owner:MESO SCALE TECH LLC
Surface marker modification of fibroblasts to target cells to specific tissue and organs for therapeutic use
PCT designated stageWO2026085031A2Genetically modified cellsSkeletal/connective tissue cellsSurface markerMedicine
The present disclosure concerns genetic modification of fibroblasts or fibroblast-derived materials (including of the fibroblasts from which the fibroblast-derived materials are derived). In specific aspects, they are modified such that they may express one or more surface markers that allow targeting to a tissue and / or organ of interest. In some aspects, they are modified such that they may lose one or more surface markers that then allow targeting to a tissue and / or organ of interest. In certain aspects, one or more surface markers are modified that then allows targeting to a tissue and / or organ of interest.
Owner:FIBROBIOLOGICS INC
SYSTEM AND METHOD FOR INSPECTING MARKINGS ON THE SURFACE OF CONTAINERS
Owner:ALTA VISION SRL
Feature detection using language models
In various examples, feature identification using language models for autonomous and semi-autonomous systems and applications is described herein. Systems and methods described herein may use a language model(s) to determine information associated with features, such as surface markings, within an environment. For example, sensor data may be used to generate one or more images or other sensor data representations corresponding to an environment. The image(s) may then be processed to generate input data (e.g., input tokens) that is applied to the language model(s). Based at least on processing the input data, the language model(s) may be trained to output data (e.g., output tokens) representing information associated with one or more features. Additionally, the output data may be used to determine the information associated the feature(s) within the environment, where the information may then be used to update a map and / or navigate one or more machines within the environment.
Owner:NVIDIA CORP
Culture medium for closed culture of mesenchymal stem cells and culture method and application thereof
This invention provides a culture medium for closed-system culture of mesenchymal stem cells, comprising the following components: 1% (v / v) human platelet lysate, 10-15 g / L basal culture medium powder, 15-20 mM HEPES, 1.0-2.0 g / L sodium bicarbonate, and 0.1-1.0 g / L sodium chloride; wherein the basal culture medium powder includes non-essential amino acids, D-glucose, L-glutamine, specific growth factors, inorganic salts, and vitamins. Using the culture medium provided by this invention for mesenchymal stem cell culture eliminates the need for exogenous CO2, reducing equipment costs and process complexity; furthermore, it results in cell viability ≥97%, more concentrated particle size distribution, and more stable expression of surface markers, which is beneficial for large-scale production.
Owner:WUHAN CELL ENG CENT CO LTD
High-intensity LED UV curing and surface marking system.
The invention relates to a surface marking system (1) for the application and UV curing of a surface marking, the system (1) comprising at least one paint applicator (6), at least one LED UV lamp array (4), an on-board rechargeable power pack (3) and an air-cooling assembly, wherein the system (1) is operable to cure in a single pass, in ambient air and without the use of glass beads or other optically-transmissive fillers, a UV-curable coating having a dry-film thickness of up to 500 µm at a travel speed of at least 1 km / h. The invention further relates to a method of marking a surface with a surface marking system (1) of the invention.
Owner:STRIPING STARS BV
Surface marker binding domain insertions in vp3 capsid proteins of aav and methods for producing recombinant aav
Owner:UNIVERSITAETSKLINIKUM HAMBURG EPPENDORF +1
Markers of dopaminergic neuronal precursor cells and uses thereof
The present application relates to the field of medical biotechnology, and provides a dopaminergic neuron precursor cell surface marker F3 and / or SSTR2, and high-purity dopaminergic neuron precursor cells are obtained by screening the dopaminergic neuron precursor cells using the marker, and the dopaminergic neuron precursor cells have a higher efficiency of differentiating into dopaminergic neurons.
Owner:SHENZHEN HUADA GENE INST +1
Culture method of pilose antler stem cells
The invention discloses a culture method of cornu cervi pantotrichum stem cells, and belongs to the technical field of tissue engineering. The culture method comprises the following steps: taking antler stem periosteum tissue, refrigerating and transporting the antler stem periosteum tissue through a special transportation preserving fluid, cutting, cleaning and centrifuging to obtain tissue precipitate; resuspending the precipitate by using an optimized serum-free culture medium, inoculating to a culture dish pre-coated with gelatin according to a specific density, standing and culturing, and removing non-adherent cells; after trypsinization and centrifugation, cells are resuspended by using a sorting buffer solution, and a cell population of a specific surface marker is screened by using a flow cytometry sorter, so that the antler stem cells are obtained; and finally, carrying out passage amplification under a low-oxygen condition to obtain the pilose antler stem cells after passage amplification. By optimizing a transportation and preservation system, a culture environment and a sorting process, the purity, the activity and the proliferation and differentiation capacity of the pilose antler stem cells are effectively improved, the process standardization degree is high, and reliable technical support is provided for application of the pilose antler stem cells in the fields of tissue engineering, regenerative medicine and the like.
Owner:CHENGBU LUMEICHUN ECOLOGICAL AGRICULTURE COMPREHENSIVE DEVELOPMENT CO LTD