10 results about "Amniotic fluid" patented technology

The present disclosure is directed to compositions, formulations, and methods for treating diseases of the eye and other disorders. Specifically, d-MAPPS compositions, which may include d-MAPPS solutions (e.g., in liquid form and / or administered as eye drops), in addition to macromolecular proteins, growth factors, mesenchymal stem cells (MSC), can be used for topical application to the eye and treatment of, for instance, tear hyperosmolarity (TH), dry eye, dry eye disease, dry eye discomfort, tear hyperosmolarity, and tear hyperosmolarity-induced pathological changes in the eyes of patients. The d-MAPPS solutions can contain mesenchymal stem cells (MSC), MSC-derived exosomes (MSC-Exos), one or more MSC-sourced growth factors, and / or immunoregulatory proteins. In some embodiments, the d-MAPPS solutions can include a sterile de-cellularized human amniotic fluid (D-HAF). In embodiments, the d-MAPPS solutions are amenable to long-term storage without the loss of biological potency.

The present application relates to the technical field of medical devices, and more particularly to an amniotic membrane breaking device capable of hiding a puncture needle. The present application provides an amniotic membrane breaking device capable of protecting the inner wall of the vagina of a lying-in woman and hiding a puncture needle while the amniotic membrane is hooked and taken out. The amniotic membrane breaking device capable of hiding a puncture needle comprises a base, fixing assemblies and a first fixing frame, etc. The lower side of the front part of the base is connected with two fixing assemblies, and the upper side of the front part of the base is connected with symmetric first fixing frames. The outer cylinder drives the inner cylinder to approach the amniotic membrane, and the outer cylinder shields the inner cylinder, so as to avoid the knife causing scratches on the inner wall of the vagina of the lying-in woman during the process of entering the body of the lying-in woman. During the process of breaking the amniotic membrane, the knife is capable of hooking the amniotic membrane by rotating the rotating rod, so as to take out the amniotic membrane after breaking, and avoid the amniotic membrane remaining in the body of the lying-in woman.

The present invention relates to the field of medical devices, and in particular to an amniotic fluid detection pad for premature rupture of membranes, comprising a pad body, wherein a water absorption layer, a dilution layer and an internal standard layer are sequentially arranged in the pad body from top to bottom; a first hollow cavity is arranged inside the dilution layer, a diluent is arranged in the first hollow cavity, a first isolation layer is detachably attached to the upper end of the first hollow cavity, and a second isolation layer is detachably attached to the lower end; a second hollow cavity is arranged inside the internal standard layer, and an internal standard liquid is arranged in the second hollow cavity; the first isolation layer is used to isolate the water absorption layer and the first hollow cavity, and the second isolation layer is used to isolate the first hollow cavity and the second hollow cavity. The present application can filter and collect liquid leaked by pregnant women in the late pregnancy, pretreat the subject's amniotic fluid with the diluent, and extract the diluted amniotic fluid with the internal standard liquid, thereby ensuring the purity of the extracted amniotic fluid and improving the accuracy of detection.

The invention relates to the technical field of amniotic fluid puncture examination, and particularly discloses a semi-automatic negative-pressure amniotic fluid puncture device which comprises a B-ultrasonic probe and a puncture assembly, and a locking assembly is arranged on the B-ultrasonic probe; the locking assembly comprises a transverse plate, a bottom plate is fixedly connected to the bottom of the transverse plate, a limiting seat is fixedly connected to the top of the bottom plate, a through hole is formed in the limiting seat, and locking rotary knobs are symmetrically installed on the two sides of the through hole; through the design of the locking assembly and the puncture assembly, during amniotic fluid puncture inspection, after a puncture point is detected and determined by means of a B-mode ultrasound probe, a through hole in the top of a bottom plate limiting seat is accurately aligned with the puncture point by moving the B-mode ultrasound probe, clear and fixed path guidance is provided for puncture operation, and the positioning mode is combined with a subsequent locking mechanism, so that the puncture accuracy is improved. Position deviation caused by external factors in the puncture process can be effectively avoided, it is ensured that the puncture needle accurately reaches the target position, and the risk of mistakenly puncturing a fetus or an umbilical cord or a placenta is greatly reduced.

Disclosed is a production method of a product that is developed for treatment of hair loss, alopecia areata (pelade or ringworm), androgenetic alopecia (AGA), hair follicle nourishment, scalp nourishment and scar, scar tissue, eczema, acne treatments, for neurodegenerative, inflammatory diseases and for immune modulation purposes (regulation of the immunological response against inflammation of human tissues and fluids, for regeneration purposes). In particular, the disclosed is a method for the production of a chemical-free product with amniotic fluid content, which has been standardized by pooling and then freeze-dried and gamma irradiated (pooled / cocktail and gamma irradiated amnion-OTIA 1.0), that has been developed to be used in the treatment of ailments such as hair loss, alopecia areata (pelade), androgenetic alopecia (AGA), hair follicle nutrition, scalp nourishment, scar, scar tissue, eczema and acne.

The invention belongs to the technical field of animal models, and particularly relates to an ECMO-removed artificial uterine animal model and a construction method thereof. The animal model comprises an animal maternal body, an in-vitro fetus and an artificial uterus, the fetus is from the animal maternal body, blood circulation is established between the animal maternal body and the fetus, the blood circulation starts from the internal carotid artery of the animal maternal body, is connected to the umbilical vein of the fetus through a pipeline and enters the body of the fetus, and after the fetal circulation, the artificial uterus enters the fetal body. Starting from the fetal umbilical artery, entering the internal jugular vein of the animal maternal body through a pipeline; the fetus is located in the artificial uterus, and the artificial uterus provides a sterile artificial amniotic fluid environment for the fetus and maintains the body temperature of the fetus. According to the method, the ECMO-removed artificial uterine animal model is successfully constructed through the pregnant sheep, and the ECMO-removed artificial uterine animal model is maintained for about 90 minutes at most. A feasible animal model is provided for early surgical treatment of fetal congenital diseases and life maintenance of premature fetuses, and a foundation is laid for future clinical transformation.

The invention relates to a stimulation generator and a stimulation method for assisting natural delivery of a pregnant woman. The stimulation generator comprises a communication unit, a processing unit and a stimulation unit. The communication unit performs data interaction with the fetal heart monitor, obtains a uterine pressure change signal related to a corresponding pregnant woman, and provides the uterine pressure change signal to the processing unit; the processing unit analyzes the change characteristic of the uterine pressure along with time, determines the generation opportunity, intensity and duration of the stimulation signal according to a preset rule, and generates a corresponding signaling to control the working state of the stimulation unit; the stimulation unit executes a specific physical or electrical stimulation action according to an instruction sent by the processing unit so as to assist the pregnant woman in managing pain and breathing rhythm in the delivery process; specific transcutaneous electrical nerve stimulation or massage stimulation signals are selectively provided to guide the pregnant woman to perform deep-inspiration slow-expiration breathing actions to resist pain. The device can guide the pregnant woman to grasp the characteristics of regular uterine contraction and correct breathing movement, and the fetus distress and sheep water pollution risk are avoided.

The utility model aims to provide an improved membrane rupture device, and relates to the technical field of medical instruments, the lower ends of a first rod and a second rod are respectively provided with a suction head, and the suction heads are connected with a negative pressure pump of a collecting assembly through catheters. The suction heads are adsorbed to the amniotic sac through negative pressure suction of the negative pressure pump, the handheld ends of the first rod and the second rod move in the opposite directions through fingers, the suction heads move in the opposite directions to clamp and wrinkle the amniotic sac, the amniotic sac is conveniently cut by the membrane rupture knife, high-position membrane rupture is achieved, the amniotic sac is sucked through the suction heads, clamping is convenient, and meanwhile the membrane rupture efficiency is improved. The hair of a fetus can be well prevented from being pinched; the suction tube is movably mounted on the mounting ring of the forceps body through a ball head structure, the suction tube is communicated with the negative pressure pump on the collecting box through the guide tube, the head end of the suction tube is adjusted to be aligned to a notch in the amniotic fluid bag by rotating the mounting cylinder, amniotic fluid in the amniotic fluid bag is sucked into the collecting box through the negative pressure pump, amniotic fluid collection is facilitated, and the character and color of the amniotic fluid can be observed conveniently.

The application relates to an amniotic fluid depth measurement method and device, computer equipment, a storage medium and a computer program product. The method comprises the following steps: acquiring a fetal ultrasound video frame, classifying the fetal ultrasound video frame, screening out an initial video frame containing a standard amniotic fluid section with a confidence higher than a preset confidence threshold, i.e. screening out a video frame not containing an amniotic fluid section and a video frame containing an amniotic fluid section but not suitable for measuring the amniotic fluid depth. Then, target region detection is performed on the initial video frame, the amniotic fluid section measurement region in the initial video frame is located, a target video frame is obtained, and the amniotic fluid depth measurement value is determined according to the amniotic fluid section measurement region in the target video frame. The method can improve the amniotic fluid depth measurement efficiency.

The invention relates to an artificial uterine system comprising a fetal chamber (1) having an interior (1a) which is delimited by at least one flexible inner wall (1b), and having an opening (1l), through which a fetus is able to be introduced into the interior (1a), and having an inflow connection and an outflow connection (1i) via which artificial amniotic fluid is able to be passed through the interior (1a), and a cover (1f) by means of which the opening (1l) of the fetal chamber (1) is able to be closed, and which has an umbilical cord feedthrough (1g) through which the umbilical cord of a fetus is able to be passed, wherein the fetal chamber (1) has a flexible outer wall (1c) arranged around the inner wall (1b), and between the inner wall (1b) and outer wall (1c) an outer space (1d) is formed which has at least one port (1j), wherein a fluid is able to be introduced into the outer space (1d) or is able to be removed from the outer space (1d) via the at least one port (1j). The invention also relates to a method for producing such a fetal chamber.