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34 results about "Fetal sex" patented technology
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Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid
InactiveUS20070212689A1Rapid determinationAddressing slow performanceMicrobiological testing/measurementMaterial analysis by optical meansCell-free fetal DNAAmniotic fluid
The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and / or testing. The inventive methods include the analysis by array-based hybridization of cell-free fetal DNA isolated from amniotic fluid. In addition to allowing the prenatal diagnosis of a variety of diseases and conditions, and the assessment of fetal characteristics such as fetal sex and chromosomal abnormalities, the new inventive methods provide substantially more information about the fetal genome in less time than it takes to perform a conventional metaphase karyotype analysis. In particular, the enhanced molecular karyotype methods provided by the present invention allow the detection of chromosomal aberrations that are not often detected prenatally such as microdeletions, microduplications and subtelomeric rearrangements.
Owner:BIANCHI DIANA W +2
Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
InactiveUS20070111233A1Improved and rapid methodHigh recovery rateSugar derivativesMicrobiological testing/measurementCell-free fetal DNAAmniotic fluid
The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and / or testing. The inventive methods include the analysis by array-based hybridization of cell-free fetal DNA isolated from amniotic fluid. In addition to allowing the prenatal diagnosis of a variety of diseases and conditions, and the assessment of fetal characteristics such as fetal sex and chromosomal abnormalities, the new inventive methods provide substantially more information about the fetal genome in less time than it takes to perform a conventional metaphase karyotype analysis. In particular, the enhanced molecular karyotype methods provided by the present invention allow the detection of chromosomal aberrations that are not often detected prenatally such as microdeletions, microduplications and subtelomeric rearrangements. Also provided are improved methods of extraction of fetal DNA from amniotic fluid.
Non-invasive prenatal genetic diagnosis using transcervical cells
InactiveUS20050003351A1Microbiological testing/measurementDisease diagnosisGenetic analysisNon invasive
A non-invasive, risk-free method of prenatal diagnosis is provided. According to the method of the present invention transcervical specimens are subjected to trophoblast-specific immuno-staining followed by FISH, PRINS, Q-FISH and / or MCB analyses and / or other DNA-based genetic analysis in order to determine fetal gender and / or identify chromosomal and / or DNA abnormalities in a fetus.
Owner:MONALIZA MEDICAL
Non-invasive prenatal genetic diagnosis using transcervical cells
InactiveUS20050181429A1Microbiological testing/measurementDisease diagnosisPrenatal diagnosisStaining
A non-invasive, risk-free method of prenatal diagnosis is provided. According to the method of the present invention transcervical specimens are subjected to trophoblast-specific immuno-staining followed by FISH, PRINS, Q-FISH and / or MCB analyses and / or other DNA-based genetic analysis in order to determine fetal gender and / or identify chromosomal and / or DNA abnormalities in a fetus. Also provided is a method of in situ chromosomal, DNA and / or RNA analysis of a prestained specimen by incubating the prestained specimen in ammonium hydroxide. Also provided is a method of identifying embryonic cells according to a nucleus / cytoplasm ratio of at least 1:1 and the presence of at least variably condensed chromatin.
Owner:MONALIZA MEDICAL
Method for recording identification of fetus sexes through B ultrasonic
InactiveCN1915177APrevent B-ultrasound operationUltrasonic/sonic/infrasonic diagnosticsInfrasonic diagnosticsComputer scienceFetus
A method for discriminating and recording the sex of fetus by ultrasonography B includes such steps as using the probe of ultrasonography B to obtain and display the image of fetus, recognizing the image for judging if it has sexual organ, and recording the sex of fetus if the display frequency of the fetus image containing sexual organ is higher than a predefined normal frequency.
Owner:TEKNOVA MEDICAL SYST LTD
Device capable of preventing the abuse of ultrasonic image inspection and method thereof
InactiveCN102048557AUltrasonic/sonic/infrasonic diagnosticsInfrasonic diagnosticsAnatomical structuresImage Inspection
The invention discloses an ultrasonic image method capable of preventing the gender determination of a foetus. According to the method, the ultrasonic image data of a foetus is analyzed. Then the formation of at least one anatomical structure of the foetus except the reproductive organ is detected. Based on the formation of the foetus, the part of ultrasonic image containing at least the reproductive organ of the foetus is predicted. Finally, the ultrasonic image is displayed, wherein the predicted part of the image is nonidentifiable. In addition, an ultrasonic system is disclosed for performing the method.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
Non-invasive fetal sex determination
ActiveUS20140256572A1Increase contentMicrobiological testing/measurementLibrary screeningNon invasiveBiology
The present invention provides methods for non-invasive determination of sex in a fetus or of Y chromosomal frequency abnormalities—indicative of aneuploidy or sex mosaicisms in a fetus—by detecting and determining the relative contribution genetic sequences from the Y chromosome in view of the percent fetal contribution in a maternal mixed sample.
Owner:ROCHE MOLECULAR SYST INC
Method for noninvasive antenatal diagnosis through separating fetal nucleated red blood cells from peripheral circulating blood of pregnant woman
InactiveCN105063181AEfficient and specific captureMicrobiological testing/measurementDiseaseRed blood cell
The invention discloses a method for noninvasive antenatal diagnosis through separating fetal nucleated red blood cells from peripheral circulating blood of a pregnant woman. The method comprises the following steps: 1, preprocessing fresh pregnant woman maternal peripheral blood: separating and enriching monocytes containing fetal nucleated red blood cells from maternal peripheral whole blood through a density gradient centrifugation technology; 2, capturing cells: adding a separated monocyte suspension to a substrate chip modified with an antibody, and carrying out standing capturing; and 3, identifying the sex of a fetus: identifying whether the nucleated red blood cells of the captured fetus contain Y chromosome or not by using an FISH probe technology (CSP-X / Y). The method for noninvasive antenatal diagnosis through separating fetal nucleated red blood cells from peripheral circulating blood of the pregnant woman can realize capture and identification of the fetal nucleated red blood cells from the maternal peripheral circulating blood, and allows the FISH analysis to be directly carried out in order to realize noninvasive antenatal diagnosis of the sex or 21-Trisomy syndrome and other chromosome diseases of the fetus.
Owner:石莹
Noninvasive prenatal genotyping of fetal sex chromosomes
ActiveUS20140019064A1Microbiological testing/measurementBiostatisticsHereditary MutationMutant allele
Methods, apparatuses, and system are provided for analyzing a maternal sample to determine whether a male fetus of a pregnant female has inherited an X-linked mutation from the mother. A percentage of fetal DNA in the sample is obtained, and cutoff values for the two possibilities (fetus inherits mutant or normal allele) are determined. A proportion of mutant alleles relative to a normal allele on the X-chromosome can then be compared to the cutoff values to make a classification of which allele is inherited. Alternatively, a number of alleles from a target region on the X-chromosome can be compared to a number of alleles from a reference region on the X-chromosome to identify a deletion or amplification. The fetal DNA percentage can be computed by counting reactions with a fetal-specific allele, and correcting the number to account for a statistical distribution among the reactions.
Owner:THE CHINESE UNIVERSITY OF HONG KONG
Devices, systems and methods for biomarker analysis
PendingUS20200263167A1Lower the volumeIncrease the effective concentrationMicrobiological testing/measurementLaboratory glasswaresCell freePhysiology
Provided herein are devices, systems, kits and methods for predicting or determining the gender of a fetus using cell free fetal nucleic acids in a small amount of maternal biological sample. Devices can be used at point of need during early stages of pregnancy and are compatible with communication devices.
Owner:JUNO DIAGNOSTICS INC
Method, primer, probe, and fluorescence PCR (polymerase chain reaction) kit for detecting gender of fetus in vitro
InactiveCN103642923AEasy to useHigh reliability of resultsMicrobiological testing/measurementDNA/RNA fragmentationPregnant weeksPhysiology
The invention discloses a method for detecting gender of fetus in vitro, which comprises the following steps: (1) centrifuging a maternal blood sample, extracting plasma and extracting the plasma DNA; (2) performing fluorescent quantitive PCR by using the extracted DNA as the template, adding a primer SRY-P1 and a probe SPY-PNA1; and (3) detecting a PCR product. The invention further discloses a primer and probe for detecting gender of fetus in vitro, and a fluorescence PCR kit for detecting the gender of the fetus in vitro. The invention provides a method for detecting the gender of the fetus in vitro at early pregnancy, and the primer SRY-P1 and the probe SPY-PNA1 are designed according to genetic information gene SRY only in men so as to perform the fluorescent quantitive PCR on the maternal blood sample. The method is used for detecting the gender of fetus in vitro, and the detection accuracy rate on the maternal pregnancy for 6 weeks can achieve 100%. The kit designed according to the method is simple to use, and the result reliability is high.
Owner:叶盛
A wireless intelligent ultrasonic fetus imaging shield method
InactiveCN106108950AHigh precision of sex part targetingProtect Sensitive InformationOrgan movement/changes detectionInfrasonic diagnosticsMultiple encryptionRadiology
The wireless intelligent ultrasonic fetal imaging shielding method of the present invention can quickly and intelligently realize gender screening of fetal ultrasonic three-dimensional and four-dimensional imaging and perform shielding. The positioning accuracy of the fetal sex position is high, and through multiple encryptions of the acquired ultrasound images, the sensitive information of the fetus is better protected, which has a positive auxiliary effect on social progress.
Owner:NINGBO MARVOTO INTELLIGENT TECH CO LTD
Wireless intelligent ultrasonic fetus imaging shielding system
InactiveCN106214183AHigh precision of sex part targetingProtect Sensitive InformationOrgan movement/changes detectionInfrasonic diagnosticsMultiple encryptionMachine vision
A wireless intelligent ultrasonic fetus imaging shielding system comprises an intelligent mobile terminal, a wireless transmission unit, an expansion processing unit, a front end configuration unit, an ultrasonic recognition unit, a motion sensor, a stepping motor unit, a fixed point shielding unit, a machine vision processing unit, a front-arranged encryption unit, a transmission encryption unit, a power source unit and a cloud data center. Sex screening of ultrasonic fetus three-dimensional and four-dimensional imaging can be achieved fast and intelligently, and shielding is carried out. The fetus sex portion located at high accuracy, fetus sensitive information is protected better by means of multiple encryption of obtained ultrasonic images, which has a positive assistant action on social progress.
Owner:NINGBO MARVOTO INTELLIGENT TECH CO LTD
Primers, probes, identification method and kit for identifying fetal chromosome sex in early pregnancy
ActiveCN110607358AQuick checkThe detection method is simpleMicrobiological testing/measurementDNA/RNA fragmentationPhysiologyChromosome regions
The present invention relates to the technical field of gene identification and specifically discloses primers, probes, an identification method and a kit for identifying fetal chromosome sex. The primers and probes for identifying the fetal sex are primers and probes designed according to a male sex determining gene SRY, and three pairs of the primers and probes designed according to gene sequences of a, b, and c regions in an AZF region of Y chromosome, respectively. The plurality of pairs of the primers and corresponding probes are designed and a four-channel fluorescence detection method is used to determine existence of the SRYgene and the Y chromosome in a detection process, and the method has characteristics of high accuracy, high detection flux and high sensitivity.
Owner:THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
Noninvasive prenatal genotyping of fetal sex chromosomes
Methods, apparatuses, and system are provided for analyzing a maternal sample to determine whether a male fetus of a pregnant female has inherited an X-linked mutation from the mother. A percentage of fetal DNA in the sample is obtained, and cutoff values for the two possibilities (fetus inherits mutant or normal allele) are determined. A proportion of mutant alleles relative to a normal allele on the X-chromosome can then be compared to the cutoff values to make a classification of which allele is inherited. Alternatively, a number of alleles from a target region on the X-chromosome can be compared to a number of alleles from a reference region on the X-chromosome to identify a deletion or amplification. The fetal DNA percentage can be computed by counting reactions with a fetal-specific allele, and correcting the number to account for a statistical distribution among the reactions.
Owner:THE CHINESE UNIVERSITY OF HONG KONG
Devices, systems and methods for biomarker analysis
PendingUS20220119801A1Minimally invasiveLow costMicrobiological testing/measurementLaboratory glasswaresCell freePhysiology
Provided herein are devices, systems, kits and methods for predicting or determining the gender of a fetus using cell free fetal nucleic acids in a small amount of maternal biological sample. Devices can be used at point of need during early stages of pregnancy and are compatible with communication devices.
Owner:JUNO DIAGNOSTICS INC
Novel method capable of differentiating fetal sex and fetal sex chromosome abnormality on various platforms
The present invention relates to a method capable of, in order to diagnose fetal sex chromosome aneuploidy, differentiating Kleinfeiter's syndrome (XXY), triple X syndrome (XXX), and Turner's syndrome (monosomy X, XO) as well as male (XY) and female (XX) by using copy number variation (CNV). The differentiation method according to the present invention has significantly high sensitivity and accuracy since the reference line is evenly adjusted by performing normalization regardless of the kinds of platform and data. The present invention is useful in diagnosing the sex chromosome abnormality at an early stage through easy diagnosis of sex chromosomes X and Y, which are hard to diagnose, since an analysis is possible even with a small amount of fetal chromosomes, which corresponds to an advantage of noninvasive prenatal diagnosis, and copies are redundant.
Owner:EONEDIAGNOMICS CO LTD
Kit for prenatal screening of false positive by using peripheral blood fetal free DNA
PendingCN111286529ARelieve painEnsure safetyMicrobiological testing/measurementPrenatal screeningBiomedicine
Owner:CHANGZHOU MATERNAL & CHILD HEALTH CARE HOSPITAL
Method of detecting a fetal chromosomal abnormality
The invention relates to a novel method of detecting a fetal chromosomal abnormality, in particular, the invention relates to the detection of trisomy 21 (Down's syndrome) which comprises enrichment of the analysed fragment sizes from approximately 100bp to approximately 150bp. The invention also relates to kits for performing said method. The invention also relates to a method of predicting the gender of a fetus within a pregnant female subject.
Owner:PREMAITHA LTD
Non-invasive fetal sex determination
The present invention provides methods for non-invasive determination of sex in a fetus or of Y chromosomal frequency abnormalities—indicative of aneuploidy or sex mosaicisms in a fetus—by detecting and determining the relative contribution genetic sequences from the Y chromosome in view of the percent fetal contribution in a maternal mixed sample.
Owner:ROCHE MOLECULAR SYST INC
Reagent and kit for detecting sexual accompanying hereditary disease of fetus
PendingCN114107481ARealize non-invasive safety detectionImprove detection accuracyMicrobiological testing/measurementDNA/RNA fragmentationY chromosomeGynecology
The invention discloses a reagent and a kit for detecting sex-associated hereditary diseases of fetuses. The reagent for detecting the sex-associated hereditary disease of the fetus comprises a Y chromosome specific primer and a Y chromosome specific probe, an upstream primer of the Y chromosome specific primer is Seq ID No.1, a downstream primer of the Y chromosome specific primer is a sequence shown as Seq ID No.2, and the Y chromosome specific probe is a probe with a fluorescent group at the 5'end and a quenching group at the 3 'end of a sequence shown as Seq ID No.3. According to the reagent for detecting the sex-associated hereditary disease of the fetus, the sex of the fetus can be judged by detecting blood of a pregnant woman, and the sex-associated hereditary disease is detected; the sex-associated hereditary disease related to the gender of the fetus can be found as soon as possible in the early pregnancy stage, and reference is provided for related treatment.
Owner:深圳知因细胞生物科技有限公司
Methods, compositions, and kits for determining the sex of a fetus
PendingUS20220251650A1Improve accuracyHigh sensitivityMicrobiological testing/measurementCell freePhysiology
Owner:GATEWAY GENOMICS LLC
Bovine embryo sex development related gene, encoding protein and preparation method thereof
The invention discloses a bovine embryo sex development related gene SOX9, relating to the biological field. A nucleotide sequence of the related gene is as shown by SEQ ID NO.1. The invention also provides an encoding protein of the gene, and an amino acid sequence of the encoding protein is as shown by SEQ ID NO.3. The invention also provides an extracting method of the gene, comprising the following steps of: extracting a total RNA (Ribonucleic Acid) from a bovine embryo genital ridge, amplifying by an RT-PCR (Reverse Transcription-Polymerase Chain Reaction) method, and cloning to a complete expressed sequence of the bovine embryo sex development related gene SOX9 by combining an RACE and nest-type PCR technology. The gene can be used for controlling the sex of a bovine offspring and has good application prospect.
Owner:INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
Method of detecting a fetal chromosomal abnormality
The invention relates to a novel method of detecting a fetal chromosomal abnormality, in particular, the invention relates to the detection of trisomy 21 (Down's syndrome) which comprises enrichment of the analysed fragment sizes from approximately 100 bp to approximately 150 bp. The invention also relates to kits for performing said method. The invention also relates to a method of predicting the gender of a fetus within a pregnant female subject.
Owner:PREMAITHA LTD
Non-invasive fetal sex determination
Owner:ROCHE MOLECULAR SYST INC
Primers and probes, identification method and kit for identifying fetal chromosome sex in the first trimester
ActiveCN110607358BQuick checkThe detection method is simpleMicrobiological testing/measurementDNA/RNA fragmentationFirst trimesterMedicine
The present invention relates to the technical field of gene identification and specifically discloses primers, probes, an identification method and a kit for identifying fetal chromosome sex. The primers and probes for identifying the fetal sex are primers and probes designed according to a male sex determining gene SRY, and three pairs of the primers and probes designed according to gene sequences of a, b, and c regions in an AZF region of Y chromosome, respectively. The plurality of pairs of the primers and corresponding probes are designed and a four-channel fluorescence detection method is used to determine existence of the SRYgene and the Y chromosome in a detection process, and the method has characteristics of high accuracy, high detection flux and high sensitivity.
Owner:THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
Detection of risk of pre-eclampsia in obese pregnant women
PendingUS20220181030A1Easy to controlPromote stratificationHealth-index calculationMass spectrometric analysisObstetricsMetabolite
A computer implemented method of early prediction of risk of pre-eclampsia in a pregnant obese woman is described. The method comprises the steps of inputting abundance values for a panel of obese pregnancy specific metabolite biomarkers obtained from an assayed biological sample into a computational model, in which the biological sample is obtained from an obese pregnant woman at 8 to 24 weeks of pregnancy, and inputting a patient parameter for the pregnant obese woman into the computational model selected from at least one of ethnicity, risk of gestational diabetes, fetal sex, number of pregnancies and level of obesity. The computational model is configured to select a subset comprising at least two of the obese pregnancy specific metabolite biomarkers based on the patient parameter input, correlate abundance values for the subset of obese pregnancy specific metabolite biomarkers with risk of pre-eclampsia, and output a predicted risk of pre-eclampsia for the pregnant obese woman.
Owner:METABOLOMIC DIAGNOSTICS LEMITED
Male fetus cffDNA content calculation method based on X chromosome
ActiveCN113012759AReduce testing costsLower Sequencing CostsProteomicsGenomicsX chromosomePhysiology
The invention discloses a male fetus cffDNA content calculation method based on an X chromosome. The male fetus cffDNA content calculation method comprises the following steps: S1, obtaining an original sequencing gene sequence; s2, counting the sequencing gene sequences; s3, standardizing the number of sequencing gene sequences; s4, recognizing the gender of the fetus; s5, calculating a copy baseline in a female fetal X chromosome window; s6, calculating a male fetus X chromosome predictive factor and detecting an abnormal point; and step S7, obtaining the cffDNA content of the male fetus. The method has the advantages of simple principle, simplicity and convenience in operation, high accuracy, high detection efficiency and the like.
Owner:GENETALKS BIO TECH CHANGSHA CO LTD
Detection of risk of pre-eclampsia in obese pregnant women
A computer implemented method of early prediction of risk of pre-eclampsia in a pregnant obese woman is described. The method comprises the steps of inputting abundance values for a panel of obese pregnancy specific metabolite biomarkers obtained from an assayed biological sample into a computational model, in which the biological sample is obtained from an obese pregnant woman at 8 to 24 weeks of pregnancy, and inputting a patient parameter for the pregnant obese woman into the computational model selected from at least one of ethnicity, risk of gestational diabetes, fetal sex, number of pregnancies and level of obesity. The computational model is configured to select a subset comprising at least two of the obese pregnancy specific metabolite biomarkers based on the patient parameter input, correlate abundance values for the subset of obese pregnancy specific metabolite biomarkers with risk of pre-eclampsia, and output a predicted risk of pre-eclampsia for the pregnant obese woman.
Owner:代谢组学诊断有限公司
Method capable of differentiating fetal sex and fetal sex chromosome abnormality on various platforms
The present invention relates to a method capable of, in order to diagnose fetal sex chromosome aneuploidy, differentiating Kleinfeiter's syndrome (XXY), triple X syndrome (XXX), and Turner's syndrome (monosomy X, XO) as well as male (XY) and female (XX) by using copy number variation (CNV). The differentiation method according to the present invention has significantly high sensitivity and accuracy since the reference line is evenly adjusted by performing normalization regardless of the kinds of platform and data. The present invention is useful in diagnosing the sex chromosome abnormality at an early stage through easy diagnosis of sex chromosomes X and Y, which are hard to diagnose, since an analysis is possible even with a small amount of fetal chromosomes, which corresponds to an advantage of noninvasive prenatal diagnosis, and copies are redundant.
Owner:EONEDIAGNOMICS CO LTD
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