7results about How to "Increase the effective concentration" patented technology

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

This invention relates to the field of food processing technology and discloses a method for improving the stability and bioavailability of astaxanthin by combining piperine with a whey protein fibrillary-algin complex. The method specifically includes the following steps: S1. Preparation of whey protein fibrillary; S2. Loading piperine onto whey protein fibrillary; S3. Complexation of piperine-loaded whey protein fibrillary with sodium alginate; S4. Preparation of an astaxanthin-piperine co-encapsulated emulsion. This invention constructs a three-dimensional network resistant to pepsin hydrolysis through electrostatic complexation; enhances the effective concentration of piperine in the intestine through co-encapsulation, efficiently regulating the expression of P-gp efflux transport proteins and the transmembrane absorption of astaxanthin; and utilizes the functional property of piperine to inhibit the activity of P-gp efflux transport proteins to achieve efficient absorption of astaxanthin.

This invention discloses a method for preparing lithium perfluoroalkyl disulfonylimide, belonging to the field of chemical synthesis technology. The method involves cooling an acetonitrile solution containing triethylenetetramine formate ionic liquid to -50°C to -30°C, then introducing ammonia gas, followed by the sequential addition of anhydrous lithium hydroxide, triethylsilane, and 1-hydroxybenzotriazole, and then adding perfluoroalkyl disulfonyl fluoride as shown in Formula 1. A two-stage heating reaction is then carried out to obtain lithium perfluoroalkyl disulfonylimide as shown in Formula 2. This invention provides a highly selective and simple one-step synthetic route, simultaneously achieving high purity, low moisture content, and high yield of the product, providing strong technical support for the efficient industrial production and high-end electrochemical applications of lithium perfluoroalkyl disulfonylimide.

The invention discloses an ultrasonic labeling guided targeting nano liquid drop. The nano liquid drop comprises an inner core and a polymer layer coating the surface of the inner core, the inner core is perfluorinated carbon; the polymer layer comprises fluorine-containing polycaprolactone, a copolymer as shown in a formula I, an ultrasonic activation prodrug and a sound-sensitive agent; the perfluorinated carbon can be dissolved by the fluorine-containing polycaprolactone. According to the application, the tumor tissue is precisely treated by utilizing ultrasound to induce the tumor tissue to highly express the heat shock protein, so that the nano liquid drops modified with the heat shock protein targeting polypeptide are efficiently enriched at the tumor part, and the difference between the drug concentration in the tumor tissue and the drug concentration in other normal tissues is remarkably increased; the drug targeting selectivity and the drug release accuracy are improved.

The invention belongs to the technical field of cosmetics and skin external preparations, and discloses antioxidant brightening essence of a dual-molecular-weight PDRN composition and a preparation method of the antioxidant brightening essence. The antioxidant brightening essence of the dual-molecular-weight PDRN composition comprises a first poly (deoxyribonucleotide) component of which the average molecular weight is enriched in a range of 50-200kDa and a second poly (deoxyribonucleotide) component of which the average molecular weight is enriched in a range of 600-1000kDa, the weight ratio of the first poly-deoxyribonucleotide component to the second poly-deoxyribonucleotide component is 1: (1-10); through scientific compounding of double-molecular-weight PDRN, perfect combination of instant anti-oxidation brightening and long-acting repair anti-wrinkle is realized, and the efficacy coverage is comprehensive.

This invention relates to the field of photopolymerization materials technology, and more particularly to a low-migration, oxygen-resistant photoinitiator, its preparation method, and applications, applicable to environmentally friendly coatings, 3D printing resins, and biomedical adhesives. The nano-photoinitiator of this invention is prepared from a trivalent iron salt compound and an organic ligand containing a carboxylic acid group; it generates initiating free radicals under ultraviolet and / or visible light irradiation, which are used to initiate the free radical polymerization reaction of unsaturated monomers. The system of this invention can still achieve rapid and complete curing in an air environment, significantly reducing or avoiding the oxygen inhibition effect commonly found in traditional free radical photocuring, and exhibits high stability; simultaneously, it has advantages such as wide availability of raw materials, low cost, easy aqueous phase conversion, and reduced potential irritation and migration risks, thus improving the system's biocompatibility and environmental friendliness.

This invention relates to a method for preparing a perfluorinated carbon nanoemulsion hydrogen carrier and its application. (1) Polylactic acid-glycolic acid copolymer is dissolved in a solvent, perfluorinated carbon is added, and then a polyvinyl alcohol solution is added and mixed before ultrasonic treatment. The perfluorinated carbon includes perfluorohexane and perfluoronaphthane. (2) Polyvinyl alcohol solution is added to the ultrasonically treated solution in step (1) for homogenization, stirring, centrifugation, and washing to obtain nanoparticles. (3) The nanoparticles obtained in step (2) are dispersed in deionized water, and a surfactant is added and stirred to obtain the final product. The perfluorinated carbon nanoemulsion hydrogen carrier of this invention is used for efficient dissolution and transport of H2 to alleviate the limitation of H2 mass transfer, continuously provide reducing power for the microbial electrosynthesis process, and improve the yield, efficiency, and system stability of acetic acid without affecting the activity of microorganisms.