277results about How to "Increase the effective concentration" patented technology

Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.

Compositions including zinc compounds and select amino acids in a carrier base, and methods of skin treatment with such compositions, are described. The compositions are useful for healing skin and minimizing the irritation incurred from contact with the zinc compound without loss of zinc availability during absorption into the integument.

The invention mainly relates to a method for preparing a protein feed by fermentation on straw and cake using aerobic mixed bacteria. The method for preparing a protein feed by fermentation on straw and cake using aerobic mixed bacteria is mainly characterized by comprising the following steps of: uniformly stirring straw, cake, wheat bran and corn flour, and enabling the water content thereof toachieve 50-60%; adding ammonium sulphate having an amount of 0.5-4% relative to the total amount of dry materials and urea having an amount of 0.5-3% relative to the total amount of dry materials; adjusting pH to 5.5-6.5 by 1% lime water; joining the raw materials in bacterial solution having an amount of 8-12% relative to the total amount of dry materials, obtained by mixing geotrichum candidum,lactic acid bacteria and bacillus licheniformis, and having a ratio by weight of 50-60% of geotrichum candidum to 30-35% of lactic acid bacteria to 5-10% of bacillus licheniformis; and fermenting for18-24 hours in a ventilation condition at a temperature of 28-32 DEG C, so as to prepare the fermented protein feed. The method for preparing a protein feed by fermentation on straw and cake using aerobic mixed bacteria disclosed by the invention utilizes modern bio-technology, optimizes the best combined bacteria, has simple and convenient production process, saves equipments and energies, and reduces the needed investment.

An optical recording material which when exposed to actinic radiation produces a change in optical properties in the exposed regions, thereby providing a pattern of intelligence for storing and retrieving information, the recording material having: a) a polymer containing a covalently bound reactant moiety which is capable of undergoing a chemical transformation upon a one electron oxidation, thus causing the change in optical properties in the exposed regions; and b) a sensitizer capable of absorbing actinic radiation to cause an initial one electron oxidation of the reactant.

The invention provides a mitochondria-targeting micelle drug delivery system capable of reversing drug resistance of tumor. The drug delivery system is a polymer micelle which is obtained through self assembly of a block copolymer folic acid-polyethylene glycol-polyaspartic acid, also a mitochondria-targeting doxorubicin-triphenylphosphine compound (TPP-DOX) is synthesized, and doxorubicin and doxorubicin-triphenylphosphine (DOX / TPP-DOX) are together wrapped in the polymer micelle, so that the drug delivery micelle is obtained. The drug delivery system is capable of giving play to active targeting effect and possesses acid-sensitive characteristic, is capable of simultaneously releasing doxorubicin in mitochondria and nucleus in a positioning way after entering a tumor cell, helps to enhance antitumor activity and reverse the drug resistance of tumor, and provides a new strategy for the dilemma that chemotherapeutics drugs easily generate drug resistance.

The invention relates to a preparation method of a ZSM-5 molecular sieve. The method comprises performing assistant crystallization of a ZSM-5 molecular sieve precursor by utilizing steam of a template agent solution to obtain an ammonium-type ZSM-5 molecular sieve; and optionally, removing the template agent from the ammonium-type ZSM-5 molecular sieve to obtain a hydrogen-type ZSM-5 molecular sieve. According to the invention, the preparation method of the ZSM-5 molecular sieve abandons a conventional continuous medium in a crystallization process, and alkali metals or hydroxides of alkali metals, overcomes the technical prejudice in the prior art, and provides a novel synthesis idea for the field.

The invention discloses a Ca / Zn composite stabilizer which comprises components in parts by mass as follows: 14-19 parts of calcium stearate, 11-16 parts of zinc stearate, 2-6 parts of beta-diketone compounds, 0.5-3 parts of beta-diketone metal complexes, 8-13 parts of stearic acid, 0.5-5 parts of polyol, 6-11 parts of hydrotalcite, 0.5-4 parts of phosphite ester, 0.5-4 parts of an antioxidant, 2-6 parts of calcium carbonate and 3-6 parts of polyethylene wax. The beta-diketone metal complexes are directly added to a Ca / Zn composite stabilizer system, by means of increase of the effective concentration of the beta-diketone metal ion complexes of the stabilizer in PVC (polyvinyl chloride) thermal stabilization, the synergistic effect is promoted, and the thermal stability of the Ca / Zn composite stabilizer is improved.

The invention relates to a polynary composite water treatment agent which mainly comprises terpolymer containing sulfonic acid radicals, organophosphorus acids, zinc salts and metal inhibitors, wherein the effective concentration weight ratio being 20-40 : 1-10 : 0.5-4 : 0-3.

The invention discloses a top coating for a coating layer of a double-sided coating white board as well as a preparation method and application thereof. As the top coating, the double-sided coating white board after being applied and coated by a coating machine not only is suitable for high-grade printing but also is suitable for vacuum forming. The top coating comprises the following components in parts by mass: 20 to 50 parts of kaolin, 50 to 80 parts of calcium carbonate, 10 to 18 parts of latex and 25 to 35 parts of water. The top coating also contains the components of a dispersant, a lubricant, a water repellent agent, a bactericide, a pH regulator and a functional assistant of 0.6 to 3.0 parts by mass of PC4200 soybean protein. By adding the functional assistant, the closure property of the coating layer can be opened, the covering property of the coating is enhanced, the use quantity of wood pulp is reduced, the smoothness of finished paper is lowered, and the infiltration of vacuum forming oil is benefited. The coating is applied and coated on a paperboard by the coating machine, can enable the paperboard to have favorable printing ink acceptance, improves the covering property of a paper face greatly and has lower smoothness and roughness and favorable printing adaptability.

The invention discloses a polyacid-based metal organic frame proton conductor material of inorganic acid molecule functionalization. Polyanions and crystal water molecules are domain-limited in pore canals of the metal organic frame, wherein the structure thereof is HAaPOM-MOF, wherein HA is one of H2SO4 or H3PO4; and POM-MOF is the polyacid-based metal organic frame, and is one of [Ag8L5](PMo12O40)(H2O)10 or [Ag8L5](PW12O40)(H2O)13, wherein L is 5-phenyl tetrazole. The invention further discloses a preparation method for the polyacid-based metal organic frame proton conductor material of the inorganic acid molecule functionalization. The preparation method comprises the following steps: firstly preparing the polyacid-based metal organic frame, uniformly mixing the prepared polyacid-based metal organic frame and HA solution, separating the material, washing, drying to obtain the polyacid-based metal organic frame proton conductor material of the inorganic acid molecule functionalization.

The present invention relates to a preparation method of crystal polymer / carbon nano-pipe conductive composite material. The method is characterized in that crystal polymer, carbon nano-pipe and inorganic powder are mixed according to a certain proportion and then the processing equipment of macromolecular material is adopted for fusing, mixing and completing the granulation. The present invention with simple method and easy operation can obtain the conductive composite material with good electric conduction and good comprehensive performance through one-step method, and can be applied in the fields of automobile, electric and electronic instrument, office equipment and industrial machinery. The present invention can meet and expand the requirements of crystal macromolecular material for various purposes.

The invention discloses a preparation method of a photoelectrochemical diethylstilbestrol sensor and belongs to the technical field of novel nano functional materials and biosensors. Firstly, a novel two-dimensional nano photoelectric material, namely a copper-doped nano photoelectric material, specifically a two-dimensional nano composite Cu-TiO2 / MoS2 obtained through in-situ compounding of molybdenum disulfide on a copper-doped titanium dioxide nano cube is prepared, and an diethylstilbestrol antibody is loaded and alkaline phosphatase is fixed to the material by the application of good biocompatibility and a large specific surface area of the material. During detection, due to the fact that alkaline phosphatase can catalyze L-ascorbic acid-2-trisodium phosphate AAP to generate L-ascorbic acid AA in situ and then provide an electron donor for photoelectric detection, by the application of the influences of specific quantitative combination of the antibody and an antigen on electron transmission capacity, the photoelectric current intensity is lowered accordingly, and finally the photoelectric sensor for detecting diethylstilbestrol through an unmarked photoelectrochemical method is constructed.

Methods and devices for performing biological and chemical reactions are disclosed. The devices and methods include a reaction chamber formed on a base substrate, a spacer, and a gripping element adapted to receive a cover substrate.

The invention mainly relates to a method for preparing protein feed from straw and inedible vegetables through mixed bacteria aerobic fermentation. The method is mainly characterized by comprising the following steps: uniformly stirring straw, inedible vegetables, rapeseed meal and bran till the moisture content reaches 50-60 percent; adding ammonium sulfate the mass of which accounts for 2-6 percent of the total mass of the dry materials, and urea the mass of which accounts for 1-4 percent of the total mass of the dry materials; regulating the pH value to be 5.5-6.5 by using 1 percent of whitewash; inoculating bacteria liquor which is formed by mixing Geotrichum candidum Link, lactic acid bacteria and aspergillus niger and the mass of which accounts for 8-12 percent of the total mass of the dry materials, wherein the mixed bacteria liquor comprises the following components in percentage by weight: 50-70 percent of Geotrichum candidum Link, 20-25 percent of lactic acid bacteria and 5-10 percent of aspergillus niger; fermenting at the temperature of 28-32 DEG C under ventilation conditions for 24-36 hours, thereby preparing the fermented protein feed. According to the method, by utilizing the modern biotechnology, optimal combined bacteria are optimized, the production process is simple and convenient, equipment and energy are saved, and the needed investment is low.

The invention discloses nucleic acid for detecting Zika virus, a real-time fluorescence RPA kit and a detection method thereof. The real-time fluorescence RPA kit is convenient to use, the quantity of reagents adopted is small, the cost is low, the compatibility of required instruments is high, reaction can be performed on a real-time fluorescence PCR instrument and instruments with a fluorescent trapping function, and the greatest advantage of the kit lines in performing isothermal amplication and being capable of detecting fluorescence signals in real time within 10 to 30 min. The detection method greatly simplifies the operation process, reduces steps of repetitive operation, saves time, reduces labor force consumed by repetitive operation, and effectively lowers the cost, and a detection result shows that the method is high in specificity and sensitivity, and rapid and accurate screening of Zika virus is realized.

The invention provides the application of a polymer system based on beta-cyclodextrin in P-glycoprotein of suppressive tumour cells. The polymer consists of the beta-cyclodextrin and grafted amphipathy polymer. The star-shaped amphipathy polymer based on beta-CD and provided by the invention has remarkable effect of restraining P-gp protein, and the restraining effect thereof is obviously superior to the inhibitor CsA of the P-gp protein. The polymer of the invention has the characteristics of low cytotoxicity, good biocompatibility, biodegradability, long intracorporeal circulation time and the like, and provides an ideal dose carrier material for hydrophobic antineoplastic agents.

The invention relates to a preparation method of a ZSM-5 molecular sieve. The method comprises performing solid-phase thermal crystallization of a ZSM-5 molecular sieve precursor to obtain a sodium-type ZSM-5 molecular sieve. The preparation method of the ZSM-5 molecular sieve is high in reaction speed and short in crystallization time, is high in single-reactor yield and production efficiency, and is not limited by silicon-aluminum sources. According to the invention, the prepared ZSM-5 molecular sieve has advantages of nanoscale, high crystallization degree, and excellent physical and chemical performance.

The invention discloses a double-layer sustained and controlled release nanoparticle and a preparation method thereof and application in preparation of antitumor medicines. The double-layer sustained and controlled release nanoparticle is formed by a lactic acid-glycolic acid copolymer nanoparticle inner core and a polyethylene glycol questin grafting chitosan casing covering an outer layer of the lactic acid-glycolic acid copolymer nanoparticle inner core and can simultaneously load hydrophilic and lipophilic medicines. The drug entrapment rate is high, time-ordered release of inner layer medicines and outer layer medicines can be achieved, the double-layer sustained and controlled release nanoparticle has the effects of sustained release and controlled release, and in addition, the double-layer sustained and controlled release nanoparticle further has the advantages of being controllable in grain size, uniform in particle size distribution, smooth and round in forma and good in stability and dispersibility and the like.

The invention discloses an insulated and heat-conductive polybutylene terephthalate / polycarbonate composite material and a preparation method thereof. The insulated and heat-conductive polybutylene terephthalate / polycarbonate composite material comprises the following components in parts by weight: 20-50 parts of polybutylene terephthalate, 10-30 parts of polycarbonate, 20-70 parts of a heat-conductive filler, 0-2 parts of a transesterification inhibitor, 0.5-2 parts of a silane coupling agent and 0-2 parts of a lubricating agent. The insulated and heat-conductive polybutylene terephthalate / polycarbonate composite material has good heat-conducting property and mechanical property and excellent insulating property and can be applied to such parts with heat dissipating and insulating requirements as LED heat dissipating lamp holders or shells of other electronic and electric products.

The invention provides a fully-dissociable type polyethylene glycol-poly(L-glutamate-gamma-benzyl ester)-polyethyleneimine copolymer as well as a synthesizing method and application thereof. The method comprises the following steps: performing cystamine modification on terminated methoxy polyethylene glycol; initiating a ring-opening polymerization of gamma-benzyl ester-L-glutamate-N-carboxyanhydride by utilizing the terminated amine of the terminated methoxy polyethylene glycol; connecting the product in the ring-opening polymerization and polyethyleneimine by utilizing 2,2'-dithio-diethyl isocyanate by virtue of an addition reaction to obtain the target product. According to the method, the synthesized copolymer is amphipathic, can be self-assembled to form nano-particles; chemotherapeutic medicines and genetic medicines can be simultaneously loaded to the copolymer when the copolymer is used as a medical vector; the copolymer can be completely dissociated and disintegrated by responding glutathione and other reductive substances, so that the vector can escape from endosome to cytoplasm, medicines can be quickly released, and the treatment effect can be improved. The method can be used for controlling the molecular weight and length of each fragment in the segmented copolymer, is mild in reaction condition, and is suitable for more medicine types.

The composition of the invented acidization blocking remover liquor comprises (wt%) 3%-20% of industrial nitric acid, 0.8%-1.2% of nitric acid acidization additive and the rest is water, and the nitric acid acidization additive is formed from metal corrosion inhibitor and surfactant. Said invention can completely eliminate the near-well-bore area block of wall injection well, and has the characteristics of slow oil pipe corrosion speed, high nitric acid effective concentration, easy preparation and low cost.

The present invention relates to preparation of a new medicine Nifuratel nysfungin vagina tablet for gynecologic antisepsis and anti-inflammation. Nifuratel nysfungin can play a more complete role in curing mixed vagina infection (candida, trichomonas and bacteria) and pathogen which can not be or can not be timely and clearly diagnosed and preventing mildew secondary infection and recurrence after the treatment of other medicines. The present invention can be used for curing bacterial vaginopathy, trichomonas vaginitis, monilial vulvovaginitis, and vagina mixed infection. The advantage of the present invention lies in that the added pH buffer system ensures pH of the medicine is within 3.5 to 4.0 close to the physiological pH of vagina, thus effectively protecting the physiological environment of vagina, providing the appropriate living conditions beneficial to flora in vagina and promoting the recovery of diseases.

The invention discloses a photoelectrochemical sensor for estradiol based on a boron-doped iron cobalt oxide two-dimensional nano composite material as well as a preparation method and application of the photoelectrochemical sensor. The preparation method comprises the following steps: firstly, modifying a two-dimensional nano material g-C3N4 on ITO (Indium Tin Oxide) conductive glass by adopting an electrodeposition method; secondly, carrying out in-situ grown of iron cobalt oxide by adopting a hydrothermal method, and further preparing to obtain a working electrode loaded with the g-C3N4, doped with boron and modified by the iron cobalt oxide Bi@Fe*Co<1->*O3 / g-C3N4; finally, loading an estradiol antibody by using good biocompatibility and large specific surface area of the material. During detection, L-ascorbic acid-2-trisodium phosphate (AAP) can be catalyzed by boron-doped iron cobalt oxide Bi@Fe*Co<1->*O3 to generate L-ascorbic acid AA in situ, further an electron donor is provided for photoelectric detection, and then photocurrent intensity is correspondingly reduced by using the influence of specific combination of the antibody and antigen on electronic transmission capacity; finally, the construction of the photoelectrochemical sensor for the estradiol by adopting a mark-free photoelectrochemical detection method is realized.

The invention discloses a carbon nitride-binary metal boron oxide composite material-based bisphenol A photochemical sensor and preparation and application thereof. The preparation comprises the steps of firstly modifying a two-dimensional nano material g-C3N4 on ITO conductive glass by adopting an electrodeposition method; growing nickel-cobalt hydroxide in situ by adopting a hydrothermal method to prepare a g-C3N4-loaded and boron-doped nickel-cobalt oxide Bi@NixCo<1-x>O3 / g-C3N4-modified working electrode; and finally loading a bisphenol A antibody by adopting good biocompatibility and large specific surface area of the material, thereby completing preparation of the bisphenol A photochemical sensor. When the detection is implemented, L-ascorbic acid-2-trisodium phosphate APP can be catalyzed by the boron-doped nickel-cobalt oxide Bi@NixCo<1-x>O3 to generate the L-ascorbic acid AA in situ, so that an electron donor is provided for photoelectric detection, the photocurrent strength is correspondingly reduced by utilizing the influence on the electronic transmission capability caused by the specificity quantitative combination of the antibody and antigen, and construction of a photoelectric sensor for detecting the bisphenol A by using an unmarked photoelectrochemical technique is finally achieved.

A thiosulfate polymer composition includes an electron-accepting photosensitizer component, either as a separate compound or as an attachment to the thiosulfate polymer. The thiosulfate polymer composition can be applied to various articles and used to form a predetermined polymeric pattern after photothermal reaction to form crosslinked disulfide bonds, removing non-crosslinked polymer, and reaction with a disulfide-reactive material.

The invention relates to a preparation method capable of enhancing electric conductivity and mechanical properties of a polypropylene (PP) / nickel-coated glass fiber (NCGF) composite material. According to the method, PP, a nucleator and NCGF are processed by melt blending to obtain the PP / NCGF composite material with favorable electric conductivity and mechanical properties. The nucleator is added to enhance the crystallinity of the PP and increase the crystalline region occupied volume. Under the volume elimination effect of the crystalline region, the electric conduction glass fibers are uniformly distributed in the amorphous region to enhance the effective concentration of the amorphous region and promote the formation of the electric conduction network, thereby obviously enhancing the electric conductivity of the composite material. The added nucleator enhances the crystallinity of the PP, enables the crystal grain to be uniform and refined, and is beneficial to the enhancement of the strength of the composite material. The method is simple in operational process and can easily implement industrial production. The prepared composite material has favorable electric conductivity and stability, and can be used in the fields of electromagnetic shielding, electronic and electric appliances, static resistance and the like.

The invention discloses a high-concentration carbon hole solution for a PCB and a preparation method thereof. The finally obtained high-concentration carbon hole solution for the PCB comprises, by weight, 7-9% of conductive carbon materials, 4-8% of surface active agents, 4-8% of organic dispersing agents, 1-5% of wetting agents, pH conditioning agents and the balance water; the use amount of the pH conditioning agents enables the pH value of the high-concentration carbon hole solution for the PCB to be adjusted to 9.5-10.5. The high-concentration carbon hole solution is quite high in conductivity, good in stability and high in effective concentration, and avoids the settling problem in the using process; moreover, the frequency of replacing bath solutions is reduced, and the high-concentration carbon hole solution is nontoxic, free of pollution and environmentally friendly.

The invention relates to a method for preparing a new gynecological anti-bacterial anti-inflammatory drug, namely dithiazole vaginal effervescent tablet and a method for quality control. The dithiazole vaginal effervescent tablet is used for treating gynecopathy, anorectal diseases and skin commonly-encountered diseases such as pelvic inflammatory disease, cervical erosion, vaginitis and the like caused by anaerobic bacteria, aerobic bacteria, trichomoniasis, pure or mixed fungal infections. The dithiazole vaginal effervescent tablet is characterized in that lactic acid and a calcium lactate buffer system are added to the formulation so that the pH value of the drug is between 3.5 and 4.0 similar to the vaginal physiological pH and is advantageous to remove pathogen and infusorian, provide living conditions suitable for vaginal beneficial bacterium group of lactic acid bacteria, and promote the illness rehabilitation. Besides, the dithiazole vaginal effervescent tablet uses pharmaceutical acceptable water-soluble polymer materials such as water-soluble polymer polyethylene glycol, polyvidone K30 and the like to enwrap acidic or alkaline components of an effervescent disintegrant so as to avoid the occurrence of hidden spots or even collapsing phenomenon on the surface of the tablet caused by gas production reaction resulted from small amount of water in the storage process, and uses a ethanol solution with adhesives and surface-active agents for granulation so that the hydrolysis of clotrimazole can be prevented, the infiltration of moisture is promoted in use, the uniform collapse is accelerated, and gas bubbles are homogeneous and stable.