18results about How to "Increase the effective concentration" patented technology

The invention provides a nano-drug hydrogel composite system for bladder perfusion and application thereof, and provides a new concept for bladder perfusion drugs, i.e., hydrogel is used as a drug loading platform, and a concentration gradient is formed through permeation of urea; therefore, the nano-particles modified with the'motor 'in the hydrogel generate directional movement due to different pushing forces on the two sides. And the disorderly moving nano-particles are limited by external conditions, so that the aim of orderly and directionally moving the nano-particles is fulfilled. In the aspect of treatment, the effective concentration of the perfusion medicine is improved, deep penetration is carried out on the bladder tissue, a feasible scheme is provided for medicine delivery of deep tumor tissue, technical support and a new thought are provided for bladder perfusion treatment, and good application prospects are achieved.

The invention relates to a preparation method of a sodium alginate composite hydrogel microneedle for treating pathological scars, and belongs to the technical field of hydrogel microneedles, the microneedle takes sodium alginate as a main material, the sodium alginate is methylated to obtain methylacryloylated sodium alginate AlgMA, hollow manganese dioxide nanoparticles loaded with matrix metalloproteinase are added, and the microneedle is prepared by a hydrothermal method. A hydrogel microneedle filling solution is obtained; the preparation method comprises the following steps: transferring the hydrogel microneedle into a PDMS microneedle mold, carrying out negative pressure vacuum bubble removal, drying and concentrating twice in a drying oven, carrying out photopolymerization crosslinking, forming a solid hydrogel microneedle tip, adding a 20% PVA solution, and drying in the drying oven to form the microneedle substrate, and the preparation method is simple, convenient and efficient, has industrial application potential, and is suitable for the scenes of drug delivery, skin care and the like; according to the application of the sodium alginate composite hydrogel microneedle in pathological scar drug delivery, the sodium alginate composite hydrogel microneedle has excellent mechanical strength and biocompatibility, and painless and noninvasive drug delivery can be carried out on the surface of scar skin.

The invention provides collagen modified superoxide dismutase and a preparation method and application thereof, the preparation method comprises the following steps: dissolving collagen in water, sequentially adding superoxide dismutase, EDC and NHC into the water, and stirring in a water bath heat preservation state to obtain a flowable gel sample; diluting the obtained gel sample with water, centrifuging, and collecting a lower-layer viscous liquid; and adding the centrifuged viscous liquid into a PBS (phosphate buffer solution), and dialyzing to obtain the collagen modified superoxide dismutase. Trehalose and mannitol are added into the collagen modified superoxide dismutase, the mixture is stirred and mixed evenly, the mixture is poured into a mold to be freeze-dried and extruded to be flat, and the repairing patch is obtained. The crosslinking modified superoxide dismutase obtained in the invention has good stability, and the obtained repair patch is convenient to use, can promote wound healing, and has wide application prospects and practical significance.

The invention discloses a preparation method of hemerocallis citrina nano-composite micro powder with high flavone release rate, which comprises the following steps: carrying out freeze drying treatment on fresh hemerocallis citrina, carrying out preliminary crushing, mixing the freeze-dried hemerocallis citrina with an auxiliary material and a disintegrating agent, carrying out infrasonic resonance treatment, taking microspheres as a force application medium in the process, carrying out acoustic resonance treatment, mixing, and screening to remove large particles, so as to obtain the hemerocallis citrina nano-composite micro powder with high flavone release rate. The day lily nano composite micro powder is obtained. The processing process does not need any solvent or additional chemical reagent, does not have excessive moisture and solvent residue, is good in safety, realizes superfine grinding and self-emulsification of the raw materials under the action of infrasound resonance force application, improves the release of flavone in an aqueous solution, and improves the product quality. Meanwhile, the inclusion material can further react with insoluble flavone in the day lily to form an inclusion compound and an intermolecular complex, so that the hydrophilicity is improved, and effective substances are promoted to be directly dissolved out, and therefore, after treatment, the capacities of resisting depression and promoting intestinal peristalsis are improved, and the aim of reducing the intake of the day lily under the same dosage is fulfilled.

The invention relates to the technical field of lithium battery recovery, in particular to a method for producing cobalt oxide by recovering waste lithium batteries and recycling mother liquor in the production process. Comprising the following steps of lithium cobalt oxide battery disassembly and pretreatment, valuable metal leaching, extraction separation, hydroxyl cobalt oxide production and mother liquor recycling treatment. Citric acid and hydrogen peroxide are used as valuable metal leaching agents, efficient leaching of valuable metal such as lithium and cobalt can be achieved, dependence on strong acid is reduced, and safety risks and environmental pollution in the recovery process are reduced. The cobalt sulfate solution obtained by recycling the waste lithium cobalt oxide batteries is used for producing and preparing the hydroxyl cobalt oxide, after the hydroxyl cobalt oxide is obtained, the residual mother liquor contains a sodium hydroxide component, the mother liquor is subjected to impurity removal treatment, the recyclable alkali liquor can be obtained, the recyclable alkali liquor can be used as saponification liquid alkali to be used in the extraction separation step, resource waste is reduced, and the resource utilization rate is increased. The resource recycling rate is improved.

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

The invention discloses a multilayer vertical orientation carbon fiber silica gel heat-conducting gasket and a preparation method thereof, the multilayer vertical orientation carbon fiber silica gel heat-conducting gasket comprises silica gel layers and orientation carbon fiber layers, the silica gel layers and the orientation carbon fiber layers are alternately arranged, and the silica gel layers play roles in bonding and providing material elasticity; the orientation of carbon fibers in the orientation carbon fiber layer is achieved in a rolling brushing mode, the carbon fibers are distributed in a concentrated mode, improvement of the heat conduction performance is better facilitated, and the heat conduction gasket prepared through the method is simple and convenient in preparation process, low in price and suitable for industrial large-scale production.

The invention belongs to the field of denitration agent preparation, and provides a selective non-catalytic reduction denitration agent and a preparation method thereof. Firstly, urea is subjected to heating treatment, stable crystal phase alpha-urea is converted into beta-urea, the hydrogen bond strength and intermolecular acting force in crystals are changed due to heating, thermal motion of urea molecules is increased due to temperature rise, intermolecular arrangement is loosened, exposure of reaction sites is increased, the contact surface of the molecules is larger, and the reaction time is shortened; phosphoric acid groups are introduced into the urea subjected to heat treatment, phosphorylated urea is formed through a chemical reaction, the adsorbability and reaction activity of the phosphorylated urea are improved, and the process is beneficial to enhancing the combining capacity of the urea and NOx, so that the denitration efficiency is improved; a proper amount of sodium carbonate, sodium chloride and iron oxyhydroxide are added into a reaction system, so that the activity of the denitration agent is promoted to be improved, and nitrogen oxide pollution in industrial waste gas can be effectively treated.

This invention relates to the field of food processing technology and discloses a method for improving the stability and bioavailability of astaxanthin by combining piperine with a whey protein fibrillary-algin complex. The method specifically includes the following steps: S1. Preparation of whey protein fibrillary; S2. Loading piperine onto whey protein fibrillary; S3. Complexation of piperine-loaded whey protein fibrillary with sodium alginate; S4. Preparation of an astaxanthin-piperine co-encapsulated emulsion. This invention constructs a three-dimensional network resistant to pepsin hydrolysis through electrostatic complexation; enhances the effective concentration of piperine in the intestine through co-encapsulation, efficiently regulating the expression of P-gp efflux transport proteins and the transmembrane absorption of astaxanthin; and utilizes the functional property of piperine to inhibit the activity of P-gp efflux transport proteins to achieve efficient absorption of astaxanthin.

This invention discloses a method for preparing lithium perfluoroalkyl disulfonylimide, belonging to the field of chemical synthesis technology. The method involves cooling an acetonitrile solution containing triethylenetetramine formate ionic liquid to -50°C to -30°C, then introducing ammonia gas, followed by the sequential addition of anhydrous lithium hydroxide, triethylsilane, and 1-hydroxybenzotriazole, and then adding perfluoroalkyl disulfonyl fluoride as shown in Formula 1. A two-stage heating reaction is then carried out to obtain lithium perfluoroalkyl disulfonylimide as shown in Formula 2. This invention provides a highly selective and simple one-step synthetic route, simultaneously achieving high purity, low moisture content, and high yield of the product, providing strong technical support for the efficient industrial production and high-end electrochemical applications of lithium perfluoroalkyl disulfonylimide.

The invention discloses a fat-removing and hair-growing external preparation and a preparation method thereof, and relates to the technical field of traditional Chinese medicine hair-growing compositions. The external preparation for removing fat and growing hair is prepared by mixing and soaking 8-12 parts of cacumen biotae, 8-12 parts of pine needle, 8-12 parts of garden balsam stem, 5-10 parts of glossy privet fruit, 5-10 parts of radix polygoni multiflori preparata, 4-6 parts of wild chrysanthemum flower, 4-6 parts of mulberry leaf, 5-10 parts of dandelion, 5-10 parts of ligusticum wallichii, 5-10 parts of angelica sinensis, 5-10 parts of spina gleditsiae, 5-10 parts of cortex dictamni and 8-12 parts of Chinese honeylocust fruit, decocting, filtering, concentrating, adding 0.1-0.2 part of menthol, and mixing. The external preparation for removing fat and growing hair, which is high in effective concentration of medicines, is prepared by adopting an ancient ointment decoction technology, and has a remarkable treatment effect on alopecia seborrhoeica, alopecia areata in a resting period, alopecia areata, seborrheic dermatitis and the like; meanwhile, the combination of the cortex dictamni, the Chinese honeylocust fruit, the menthol and the foaming agent is adopted, so that the dosage form stability and the use experience feeling of the preparation can be improved.

The invention discloses a low-emission silane tail gas treatment system, and mainly relates to the field of silane tail gas treatment. Comprising a tail gas absorption tower and an alkali liquor regeneration tank, the tail gas absorption tower treats received tail gas S1, generates S2 after alkali liquor reaction and absorption and then sends the S2 into the alkali liquor tank, S3 and S4 are formed in the alkali liquor tank, S3 is pumped into the tail gas absorption tower, a stream S4 is pumped into the alkali liquor regeneration tank, a material S5 is sent into the alkali liquor regeneration tank, and a stream S7 is further pumped into the alkali liquor regeneration tank. S4, S5 and S7 are mixed and reacted in the alkali liquor regeneration tank to generate a stream S8, the stream S8 is pumped into the filter press, the stream S8 generates a stream S6 and a stream S9 under the action of the filter press, and the stream S6 is fed into the alkali liquor tank to complete cyclic utilization. The method has the beneficial effects that the slaked lime and the waste alkali liquid are mixed and reacted to generate the alkali liquid again for tail gas treatment, so that the waste alkali liquid is recycled, the discharge of the waste alkali liquid is effectively reduced, the waste of water resources during the treatment of the waste alkali liquid is reduced, and meanwhile, the concentration of the alkali liquid is ensured, so that the tail gas treatment quality is ensured.

The invention discloses an ultrasonic labeling guided targeting nano liquid drop. The nano liquid drop comprises an inner core and a polymer layer coating the surface of the inner core, the inner core is perfluorinated carbon; the polymer layer comprises fluorine-containing polycaprolactone, a copolymer as shown in a formula I, an ultrasonic activation prodrug and a sound-sensitive agent; the perfluorinated carbon can be dissolved by the fluorine-containing polycaprolactone. According to the application, the tumor tissue is precisely treated by utilizing ultrasound to induce the tumor tissue to highly express the heat shock protein, so that the nano liquid drops modified with the heat shock protein targeting polypeptide are efficiently enriched at the tumor part, and the difference between the drug concentration in the tumor tissue and the drug concentration in other normal tissues is remarkably increased; the drug targeting selectivity and the drug release accuracy are improved.

The invention belongs to the technical field of cosmetics and skin external preparations, and discloses antioxidant brightening essence of a dual-molecular-weight PDRN composition and a preparation method of the antioxidant brightening essence. The antioxidant brightening essence of the dual-molecular-weight PDRN composition comprises a first poly (deoxyribonucleotide) component of which the average molecular weight is enriched in a range of 50-200kDa and a second poly (deoxyribonucleotide) component of which the average molecular weight is enriched in a range of 600-1000kDa, the weight ratio of the first poly-deoxyribonucleotide component to the second poly-deoxyribonucleotide component is 1: (1-10); through scientific compounding of double-molecular-weight PDRN, perfect combination of instant anti-oxidation brightening and long-acting repair anti-wrinkle is realized, and the efficacy coverage is comprehensive.

This invention relates to the field of photopolymerization materials technology, and more particularly to a low-migration, oxygen-resistant photoinitiator, its preparation method, and applications, applicable to environmentally friendly coatings, 3D printing resins, and biomedical adhesives. The nano-photoinitiator of this invention is prepared from a trivalent iron salt compound and an organic ligand containing a carboxylic acid group; it generates initiating free radicals under ultraviolet and / or visible light irradiation, which are used to initiate the free radical polymerization reaction of unsaturated monomers. The system of this invention can still achieve rapid and complete curing in an air environment, significantly reducing or avoiding the oxygen inhibition effect commonly found in traditional free radical photocuring, and exhibits high stability; simultaneously, it has advantages such as wide availability of raw materials, low cost, easy aqueous phase conversion, and reduced potential irritation and migration risks, thus improving the system's biocompatibility and environmental friendliness.

This invention relates to a method for preparing a perfluorinated carbon nanoemulsion hydrogen carrier and its application. (1) Polylactic acid-glycolic acid copolymer is dissolved in a solvent, perfluorinated carbon is added, and then a polyvinyl alcohol solution is added and mixed before ultrasonic treatment. The perfluorinated carbon includes perfluorohexane and perfluoronaphthane. (2) Polyvinyl alcohol solution is added to the ultrasonically treated solution in step (1) for homogenization, stirring, centrifugation, and washing to obtain nanoparticles. (3) The nanoparticles obtained in step (2) are dispersed in deionized water, and a surfactant is added and stirred to obtain the final product. The perfluorinated carbon nanoemulsion hydrogen carrier of this invention is used for efficient dissolution and transport of H2 to alleviate the limitation of H2 mass transfer, continuously provide reducing power for the microbial electrosynthesis process, and improve the yield, efficiency, and system stability of acetic acid without affecting the activity of microorganisms.

The invention provides traditional Chinese medicine compound medicinal oil for dredging channels and relieving pain and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine compound medicinal oil is prepared from the following raw medicinal materials in parts by weight: 10-15 parts of stephania sinica diels, 10-15 parts of dragon's blood, 5-10 parts of saffron crocus, 15-20 parts of pyracantha formosana, 5-10 parts of cornu cervi pantotrichum, 15-20 parts of rhizoma drynariae and 10-15 The effects of warming yang and strengthening bones, dredging channels and collaterals, promoting blood circulation to remove blood stasis and the like are achieved; the traditional Chinese medicine has a good treatment effect on cervical spondylosis, lumbar spinal stenosis, scapulohumeral periarthritis, synovitis, knee joint degenerative pain, numbness and other clinical symptoms.

The present invention belongs to the technical field of sewage treatment devices, and discloses a sewage treatment device with a multi-stage filtering function, comprising a sewage treatment tank: four maintenance ports are arranged on the top of the sewage treatment tank, a partition plate is arranged inside the sewage treatment tank, the partition plate divides the interior of the sewage treatment tank into four spaces, a sewage reflux structure is installed inside the sewage treatment tank, the sewage reflux structure comprises a first liter water pump fixedly installed on one side of the inner wall of the sewage treatment tank, and can perform multi-stage treatment on sewage, and perform reflux treatment on unqualified sewage after treatment. Through the multi-stage treatment, the sewage can be subjected to multiple reactions and aeration treatments, which is beneficial to strengthening the removal effect of pollutants and improving the water quality of effluent. In addition, unqualified sewage can be treated by reflux to avoid environmental pollution caused by direct discharge, and reduce the impact on the surrounding environment and human health.