The invention relates to hot sauce containing turtles, shiitake mushroom stems and polygonatum. The hot sauce is characterized by being prepared from raw materials in parts by weight as follows: 170-174 parts of shiitake mushroom stems, 20-21 parts of turtles, 34-35 parts of pigskin, 15-16 parts of chicken feet, 24-25 parts of rice wine, 26-27 parts of polygonatum, 34-35 parts of black beans, 33-34 parts of wheat, 34-35 parts of flour, 7-8 parts of coriander, 20-21 parts of soybeans, 18-20 parts of zucchini, 24-25 parts of hawthorn fruits, 12-13 parts of avocadoes, 3-4 parts of hericium erinaceus, 34-45 parts of leaf lard, 15-16 parts of basil, 22-23 parts of asparagus lettuce, 12-13 parts of Jalapeno pepper, 11-14 parts of pod pepper, 1-2 parts of fructus lycii, 33-36 parts of daylily roots, 4-5 parts of a health-care blending agent, 20-21 parts of edible salt, 34-35 parts of chicken essence and an appropriate amount of water. The hot sauce has the benefits as follows: the hot sauce adopts a simple preparation process, tastes delicious and has rich nutrition due to addition of the shiitake mushroom stems, the turtles, the pigskin, the chicken feet, the polygonatum and other food materials; besides, raw sauce prepared from the zucchini, the hawthorn fruits, the avocadoes, the hericium erinaceus, the basil and the asparagus lettuce is further added, and the hot sauce has a certain health care effect and is beneficial to body health.