The invention discloses a piglet compound feed and a preparation method thereof. The piglet compound feed comprises the following components in parts by weight: 20-50 parts of corn flour, 16-40 parts of extruded corn, 10-30 parts of fermented soybean meal, 11-25 parts of extruded soybean, 5-10 parts of wheat barn, 1-3 parts of bone meal, 4-6 parts of whey mist, 10-15 parts of milk powder, 1-5 parts of glucose, 0.02-0.04 part of compound vitamin, 0.1-0.3 part of compound mineral substance, 3-5 pars of balanced grease powder, 0.6-0.9 part of lysine, 0.6-0.9 part of methionine, 0.5-1.5 parts of xylooligosaccharide, 0.05-0.25 part of mannan oligosaccharide, 0.2-0.5 part of antimicrobial peptides, 0.1-0.3 part of an acidifier, 0.5-2 parts of cedrela sinensis leaves, 0.5-4 parts of cordate houttuynia, 0.5-3 parts of Chinese Magnoliavine Fruit, 0.5-3 parts of astragalus membranaceus, 0.5-3 parts of white atractylodes rhizome, 1.5-3 parts of malt, 2-6 parts of wolfiporia extensa, 0.15-0.6 parts of curcumin and 0.1-0.3 part of selenium yeast. The piglet compound feed is good in palatability and comprehensive for nutrition; while the development of the intestinal function of a weaning piglet in early stage is promoted, the intestinal injury caused by weaning is avoided, the diseases of piglet diarrhea and the like can be obviously reduced, and the resistance to diseases and growth rate of the piglet are improved.