The invention relates to a preparation method of an oral-dissolving sustained-release traditional Chinese medicine used for treating nasopharyngitis. The invention belongs to the field of traditional Chinese medicine preparation. The medicine is prepared from entireleaf dragonhead herb, blushred isodon herb, common phellinus fungus, ginkgo leaf, small centipeda herb, cottonrose hibiscus leaf, common ducksmeat herb, stir-fried xanthium sibiricum, Asiatic pennywort herb, Manchurian wildginger herb, Chinese ephedra herb, Szechwan lovage rhizome, biod magnolia flower bud, centipede, pearl powder, honey-suckle flower, calcined yellow croaker's auricular bone, tatarinow sweetflag rhizome, nidus verspae, clove, golden thread, dried toads venom, tonkin sophora root, blackberry lily, franchet groundcherry calyx or fruit, phoenix coat, angelica archang lica, black cicada slough, puff-ball, wild mythic fungus, musk, cow-bezoar, pig bile with wrinkled gianthyssop herb, Zhejiang fritillaria cirrhosa, abnormal Chinese honeylocust fruit, tin powder, ice boron powder, and frost on dried persimmon. The oral-dissolving sustained-release traditional Chinese medicine provided by the invention can be dissolved in mouth, and can be used for relieving nasopharyngitis. During the dissolving process, with melting and sustained-release of aromatic medicines, fumigation and fusion effects are provided for nasal hollow cavities. The oral dissolving time is longer than existing medicines, and a treatment effect is substantial.