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New preparation method of Isodon excisa total diterpene

A technology for the preparation of total diterpenoids and tea leaves, which can solve the problems of environmental pollution, long production cycle, and high cost, and achieve the effects of simple extraction process, short production cycle, and low pollution

Inactive Publication Date: 2011-01-12
吉林天药药物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This extraction method is complicated, and most of the extraction solvents used are flammable and explosive dangerous goods, and the production cycle is long, the cost is also high, and it also pollutes the environment, so it is not suitable for mass production; the patent discloses a narrow baseline Fragrant tea extract and its preparation method and application (patent publication number: CN1931230), the narrow baseline pattern fragrant tea powder is extracted with water under the condition of a pressure difference of 10 to 60 MPa, concentrated, and the narrow baseline pattern fragrant tea is obtained Vegetable extract is a mixture without clear and specific ingredients; Gui Mingyu discloses a new effective part of natural medicine-the total diterpenes of urophylla sativa (patent publication number: CN1566061), which is extracted with water and processed through Total diterpenes of macroporous resins, decolorizing resins, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1kg of the medicinal material of Ceratophyllum vulgaris, extracted 3 times with 10 times 70% ethanol, 2 hours each time, filtered, combined the extracts, without concentration, directly passed through D101 macroporous resin column, eluted with 2BV 70% ethanol, collected The effluent and eluent were concentrated until there was no alcohol smell; then passed through the treated D101 macroporous resin column, first eluted 2BV with alkaline water with a pH value of 8-9, and then eluted with water until neutral, discarded. Remove the eluent, and finally use 70% ethanol to elute 3BV, collect the eluent, add medicinal activated carbon with a volume of 0.5% of the liquid, stir, set aside, filter, recover the solvent until there is no alcohol smell, add water to the concentration of 1g per 1ml The medicinal materials are placed, filtered, and dried to obtain the total diterpenoids of C. odorata. The yield was 1.55%, and the total diterpene content was 86.5%.

Embodiment 2

[0018] 1kg of the medicinal herbs of Ceratophyllum vulgaris, extracted 3 times with 10 times 80% ethanol for 2 hours each time, filtered, combined the extracts, without concentration, directly passed through D101 macroporous resin column, eluted with 2BV 80% ethanol, collected The effluent and eluent were concentrated until there was no alcohol smell; then passed through the treated D101 macroporous resin column, first eluted 1.5BV with alkaline water with a pH value of 12, and then eluted with water to neutrality and discarded Eluent, eluate 4BV with 60% ethanol at last, collect the eluate, add medicinal activated carbon with a volume of 0.3% of the medicinal solution, stir, place, filter, recover the solvent until there is no alcohol smell, and add water until each 1ml contains 1g of medicinal materials , placed, filtered, and dried to obtain the total diterpenoids of C. odorata. The yield was 1.42%, and the total diterpene content was 89.9%.

Embodiment 3

[0020] 1kg of the medicinal material of Ceratophyllum vulgaris, extracted 3 times with 10 times 60% ethanol, 2 hours each time, filtered, combined the extracts, without concentration, directly passed through AB-8 macroporous resin column, and eluted with 3BV 60% ethanol , collect the effluent and eluent, concentrate until there is no alcohol smell; then pass through the treated AB-8 macroporous resin column, first elute 2BV with alkaline water with a pH value of 7-8, and then elute with water to Neutral, discard the eluent, and finally elute 3BV with 70% ethanol, collect the eluent, add medicinal activated carbon with a volume of 0.6% of the liquid, stir, place, filter, recover the solvent until there is no alcohol smell, add water to Each 1ml contains 1g of medicinal materials, and is placed, filtered and dried to obtain the total diterpenes of Ceratophyllum oleifera. The yield was 1.64%, and the total diterpene content was 83.2%.

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PUM

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Abstract

The invention discloses a new method for preparing total diterpene from the whole plant or other plants of Isodon of Isodon excisa (Maxin.) Hara of Labiatae. plant. The new preparation method is as follows: an Isodon excise medicine is extracted by alcohol; extract does not recover solvent and adsorbs impurities by a macroporous resin column; after the solvent is recovered, the obtained product passes through the macroporous resin column again; the obtained product is eluted by alkaline water and is eluted by alcohol or methanol; and the eluent is decolorized by activated carbon, condensed and dried to obtain the total diterpene. The invention has the characteristics of simple technology, low cost and no pollution and is advanced, safe and applicable.

Description

technical field [0001] The present invention provides a new method for preparing total diterpenes from the whole herb of Labiatae. plant [Isodon excia (Maxin.) Hara] or other Isodon excia plants. It belongs to the field of natural medicine technology. Background technique [0002] Rabdosia excisa (Rabdosia excisa) is a plant of the genus Labiatae. Its efficacy is mainly used to treat gastritis, abdominal distension, amenorrhea, early cancer, snake bites, etc. (Yunnan Flora). In North Korea, it is often used to treat colds and sore throats. The plant resources of C. urophylla are widely distributed, mainly in the northeast. In recent years, studies have found that compounds with exocyclic methylene cyclopentanone structure among the diterpenoids extracted from the genus Caraway have anti-tumor and anti-cancer activities. Jilin University Gui Mingyu et al. isolated 4 new kauri-type diterpenoids exeisanin H, I, J, K and 8 known kauri-type diterpenoids from Camellia sinensis...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P31/04A61P35/00A61P39/06
Inventor 赵全成赫玉芳南敏伦李庆杰赵雪娇
Owner 吉林天药药物研发有限公司
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