The invention discloses an intelligent early warning system for preventing a pileup on a highway. The intelligent early warning system comprises a vehicle-mounted terminal and a server, wherein the server is used for storing, calculating and analyzing data; the vehicle-mounted terminal is composed of a power supply management module, an embedded processor, a satellite positioning module, a mobile communication module, a ZigBee wireless communication module, a fatigue driving detection module, a vital sign detection module, a brake detection module, an acceleration detection module, a tire pressure detection module, an oil tank temperature detection module, a dangerous goods transportation reminding module, a liquid crystal display module and a voice prompt module, and a vehicle is in communication with nearby vehicles by automatically establishing a Zigbee wireless network and has access to the server through a mobile communication network. The intelligent early warning system has the functions of highway fatigue driving early warning, driver sudden illness early warning, emergency braking early warning, brake failure early warning, tire pressure abnormity early warning, oil tank overtemperature early warning, dangerous goods transportation one-key reminding and the like on the basis of the Internet of Things, drivers are reminded to take related measures in advance in a safe distance so that collision with vehicles having potential safety hazards can be avoided, and a pileup accident on the highway is prevented effectively.