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61 results about "Ion-mobility spectrometry" patented technology

Ion-mobility spectrometry (IMS) is an analytical technique used to separate and identify ionized molecules in the gas phase based on their mobility in a carrier buffer gas. Though heavily employed for military or security purposes, such as detecting drugs and explosives, the technique also has many laboratory analytical applications, including the analysis of both small and large biomolecules. IMS instruments are extremely sensitive stand-alone devices, but are often coupled with mass spectrometry, gas chromatography or high-performance liquid chromatography in order to achieve a multi-dimensional separation. They come in various sizes, ranging from a few millimeters to several meters depending on the specific application, and are capable of operating under a broad range of conditions. IMS instruments such as microscale high-field asymmetric waveform ion mobility spectrometry can be palm-portable for use in a range of applications including volatile organic compound (VOC) monitoring, biological sample analysis, medical diagnosis and food quality monitoring. Systems operated at higher pressure (i.e. atmospheric conditions, 1 atm or 1013 hPa) are often accompanied by elevated temperature (above 100 °C), while lower pressure systems (1-20 hPa) do not require heating.

VUV lamp ionization source device with efficient heat dissipation capability

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES +1

Container explosive non-opening box intelligent inspection device based on ion mobility spectrum

The application discloses a container explosive non-opening box intelligent checking device based on ion mobility spectrometry, which comprises a connecting outer frame, a hydraulic cylinder is internally installed in the connecting outer frame, a hydraulic pump is connected to one end of the hydraulic cylinder, and a first piston is movably connected in the hydraulic cylinder. The ion mobility spectrometer and a separately designed collecting device are integrated into one equipment, a user carries the equipment by means of shoulder carrying, and a handle is equipped to facilitate holding. The air suction pipe is placed at the ventilation position of the container, the threaded rod and the first piston are driven to move transversely by hydraulic oil, the sample is pushed to the ion mobility spectrometer for analysis and detection, before the next sample test, the threaded rod is driven by the hydraulic oil to drive the polishing blade to rotate in the air suction pipe, the internal powder is scraped, the transverse thrust generated by the piston ring can extrude the gas in the air suction pipe, and thus the whole cleaning process is completed, the residues after each detection are greatly reduced, and the accuracy of the next extraction detection is avoided.
Owner:TIANJIN RES INST FOR WATER TRANSPORT ENG M O T

Pet food palatability evaluation method based on GC-IMS and prediction model construction method

The application discloses a pet food palatability evaluation method based on gas chromatography-ion mobility spectrometry (GC-IMS) and a prediction model construction method, and belongs to the technical field of pet food quality analysis. The application aims at the problems of the existing palatability evaluation, such as strong subjectivity, long cycle and lack of standardized model, and adopts headspace-GC-IMS technology to rapidly detect volatile organic compounds (VOCs) in pet food, so as to obtain a VOCs fingerprint spectrum of the sample. In combination with standard samples with known palatability test results, key palatability markers are screened through orthogonal partial least squares discriminant analysis (OPLS-DA), and a palatability prediction model is established. The application first applies the GC-IMS technology to pet food palatability evaluation, realizes objectification, rapidness and standardization of detection, overcomes the subjectivity and low efficiency of traditional methods, and can provide reliable scientific basis for formula optimization, quality control and raw material screening of pet food.
Owner:SHANDONG HAICHUANG IND & TRADE CO LTD

Method for analyzing aroma components of cooking wine based on molecular docking and odor activity value and application

PendingCN121540817AComponent separationBiotechnologyOrganoleptic evaluation
The invention discloses a method for analyzing aroma components of cooking wine based on molecular docking and an odor activity value and application. According to the method, cooking wine aroma is taken as a research object, volatile substances are detected by gas chromatography-mass spectrometry (GC-MS) and headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS), and by combining with odor activity value (OAV) analysis, the combining capacity of aroma molecules and olfactory receptors is simulated through molecular docking, characteristic aroma compounds are screened, and the aroma of the cooking wine is detected. And finally, constructing a recombinant aroma model according to the characteristic aroma compounds, carrying out sensory evaluation, and evaluating the aroma similarity of the recombinant aroma model and the natural cooking wine sample to determine the characteristic aroma components of the cooking wine. The method can be used for analyzing aroma substances of cooking wine and performing standardized flavor management.
Owner:YANGXI MEIWEI FRESH FOOD CO LTD

Photoionization ion mobility spectrometry for rapid switching of combined reagent ions and applications

The present application relates to a kind of photoionization ion mobility spectrometry of fast switching combination reagent ion, including photoionization ion mobility spectrometry, reagent ion generation device, reagent molecule carrier gas is introduced to reagent molecule into the reaction zone of ion mobility spectrometry, different types of reagent ions can be obtained by switching different gas paths and reagent molecules in positive ion mode, and the reagent ions in conventional gas flow mode are mainly (C3H6O)2H + , after switching combination gas path device, new hydrate cluster reagent ion H3O (H2O) n + Is generated by the regulation of acetone and water reagent molecule, and the reactivity is higher, the sensitivity of target detection is higher, so that by switching different gas paths, the high sensitivity and high selectivity detection of target compound can be realized, such as the detection of exhaled air ammonia and atmospheric ammonia in complex matrix background, and any sample pretreatment process is not needed.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

A method for detecting fentanyl and methantheline by using microfluidic chip and ion mobility spectrometry and application thereof

This invention discloses a method and application for detecting fentanyl and toluenethiazide using a microfluidic chip coupled with ion mobility spectrometry (IMS), belonging to the field of analytical chemistry. The method utilizes a microfluidic chip platform coupled with IMS for detection, specifically including the following steps: using a dual-channel microfluidic chip platform filled with adsorbent material, fentanyl and toluenethiazide are enriched in the sample to be tested; then, IMS is used to detect the enriched fentanyl and toluenethiazide in the sample. The detection method provided by this invention has high repeatability, minimizes operator exposure to drugs throughout the process, and greatly improves the accuracy and detection efficiency. Furthermore, the detection method provided by this invention has a short testing time, high sensitivity, and is automated and environmentally friendly, enabling rapid screening of fentanyl and toluenethiazide in multiple matrices.
Owner:XINXIANG MEDICAL UNIV

Portable medicine testing device and medicine testing method

PendingCN122330078ADrug testing methodsMedicine
This application discloses a portable drug detection device and method, relating to the field of drug identification technology, with the main objective of addressing the problem of poor detection effectiveness in existing drug testing methods. It includes: a Raman spectroscopy component, an ion mobility spectrometry component, a processor, a power module, a display component, and a sample inlet module disposed on the ion mobility spectrometry component. The processor is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the display component, and is used to identify and process the spectra acquired by the Raman spectroscopy component and the ion mobility spectrometry component to obtain drug detection results. The power module is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the processor, and is used to provide power. The display component is used to display the drug detection results. The sample inlet module is used to insert sample test strips.
Owner:中国人民解放军联勤保障部队药品仪器监督检验总站

A method for detecting the purity of doxycycline for injection

The present application relates to the technical field of pharmaceutical analysis, and specifically discloses a method for detecting the purity of doxycycline for injection. The present application mainly solves the problems caused by ion pair reagent and high-salt buffer in the existing chromatographic method, such as serious pollution of the system pipeline and the chromatographic column, difficulty in connecting with mass spectrometry for impurity structure identification, and insufficient separation degree of key polar impurities such as 4-epi doxycycline. The present application purifies the sample by physical dilution and filtration, and prepares uniform aerosol by ultrasonic atomization. The ion mobility spectrometry technology is adopted to realize the efficient separation of gas-phase ions under a weak electric field according to the difference in ion collision cross section (CCS) value, and the epimer which is difficult to distinguish by traditional methods can be excellently separated. The multi-modal sensor is used to synchronously collect ultraviolet, fluorescent and terahertz multi-dimensional optical signals. Finally, based on the intrinsic physical parameter database, the intelligent analysis is carried out by using the machine learning algorithm, and the qualitative and quantitative results are automatically output.
Owner:HAINAN WEI KANG PHARMA QIANSHAN

Thermal desorption ionization reaction device and application

The present application relates to atmospheric pressure ion manipulation technology, specifically, the present application discloses a thermal desorption ionization reaction device, specifically, a thermal desorption ionization reaction device, comprising a stainless steel metal desorption ionization cavity, the metal desorption ionization cavity is a hollow circular cylinder with an open upper end and a closed lower end, an insulating cover for sealing the open upper end is arranged on the open upper end, and a gas and ion outlet is arranged in the middle of the insulating cover; the counter electrode and the electrode with holes are connected to the high-voltage output end of the high-voltage power supply and the ground electrode (or negative electrode) respectively. The voltage applied to the counter electrode and the electrode with holes is alternating current or direct current, and the voltage amplitude is 2000V. The present application improves the consistency and stability of batch production of thermal desorption ionization modules based on integrated design, reduces power consumption and processing cost, and is beneficial to the industrialization of mass spectrometry or ion mobility spectrometry.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES +1

Nuclear biochemical monitoring system and method

The invention discloses a nuclear biochemical monitoring system and method, the system comprises a nuclear radiation detection module, a chemical toxic agent detection module, a biological factor detection module, an intelligent central control unit, a monitoring terminal and a remote command platform, the nuclear radiation detection module adopts a Geiger tube sensor to detect alpha, beta, neutron and gamma rays; the chemical toxic agent detection module is used for detecting various chemical toxic agents based on an ion mobility spectrometry technology; the biological factor detection module adopts an investigation, acquisition and detection integrated system to monitor and preliminarily screen biological aerosol, the intelligent central control unit processes, studies and judges multi-source data through 5G / Beidou communication by using a data fusion algorithm, and the monitoring terminal receives and prompts a monitoring report and a disposal scheme. The remote command platform realizes data visualization, long-term storage, multi-path alarm and emergency disposal scheme generation and issuing; according to the invention, real-time, rapid and cooperative monitoring and intelligent grading response of nuclear, biological and chemical threat factors are realized.
Owner:SHENZHEN TIANHESHIDAI ELECTRONICS EQUIP

Method for improving LC / MS analysis sensitivity

The invention relates to the technical field of liquid chromatography / mass spectrometry analysis, and discloses a method for improving LC / MS analysis sensitivity, which is suitable for detecting trace lipid metabolites (containing isomeride) of a biological sample. The core technical scheme is as follows: a magnetic molecularly imprinted polymer-solid phase support liquid-liquid extraction secondary purification system is adopted to remove matrix impurities, a gradient mobile phase containing a composite additive is matched to optimize separation, and the detection specificity is improved by an ion mobility spectrometry-segmented selective ion monitoring combined mode; and a stable isotope internal standard is synchronously introduced to correct quantitative deviation. Experiments show that the LOD of the method is as low as 0.12-0.25 ng / mL, the matrix effect is smaller than or equal to 5%, the separation degree and the recovery rate are excellent, low-abundance metabolic marker differences can be accurately captured, and a support is provided for disease diagnosis and metabonomics research.
Owner:NINGBO HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Data acquisition method and ion mobility spectrometry-mass spectrometer

A data acquisition method and ion mobility spectrometry-mass spectrometer (100) capable of effectively adapting to DDA or DIA, the data acquisition method comprising a pre-acquisition step (S1), a parent ion selection step (S2) and a daughter ion acquisition step (S3), the pre-acquisition step (S1) obtaining an ion mobility spectrometry-mass spectrometry two-dimensional heat map, the daughter ion selection step (S2) obtaining a daughter ion two-dimensional heat map, and the daughter ion acquisition step (S3) obtaining a daughter ion two-dimensional heat map; in the parent ion selection step (S2), the ion mobility analyzer (2) is configured to be in a filtering mode, parent ions are selected according to the ion mobility spectrum-mass spectrum two-dimensional heat map, and the mobility selection range of the ion mobility analyzer (2) and the mass selection range of the quadrupole mass filter (3) are correspondingly set. The data acquisition method solves the problems that an existing data acquisition method is limited in dynamic range and low in scanning efficiency.
Owner:SHIMADZU SEISAKUSHO LTD

Fish species and cooking time classification and feature marker identification method and system based on in-situ GC-IMS image

The invention relates to a fish species and cooking time classification and feature marker identification method and system based on an in-situ GC-IMS image. The method comprises the following steps: collecting two-dimensional spectrograms of volatile compounds of different fish meat at different cooking times by using gas chromatography-ion mobility spectrometry equipment, and dividing the two-dimensional spectrograms into a fish meat category data set and a cooking time data set after preprocessing; training based on the fish meat category data set to obtain a fish species classification prediction model; training by using a ResNet50 model based on the cooking time data set to obtain a fish cooking time classification prediction model; and positioning a key region of model decision by using a gradient weighted classification activation map, carrying out qualitative analysis on a compound corresponding to the key region, and determining a characteristic difference compound as a marker. The two classification prediction models can realize high-precision classification of fish types and cooking time; on the basis of the two trained models, the characteristic difference compounds can be quickly positioned and identified by using a gradient weighted classification activation map.
Owner:HAINAN UNIV

Pretreatment method of propofol-containing sample, detection method of propofol and kit

The invention relates to the technical field of biochemical detection, in particular to a pretreatment method of a propofol-containing sample, a propofol detection method and a kit. The pretreatment method of the propofol-containing sample comprises the following steps: providing the propofol-containing sample; the method comprises the following steps: adding porous polymer lipophilic magnetic beads into a sample, carrying out adsorption treatment, and then carrying out leaching treatment by using water and a methanol solution in sequence to obtain a propofol-magnetic bead compound; and eluting the propofol-magnetic bead compound by using an ammonia water methanol solution to obtain a sample to be detected. The pretreatment method provided by the invention is simple in process and low in cost, the to-be-detected sample containing propofol can be efficiently obtained, and the to-be-detected sample containing propofol can be subsequently used for high-sensitivity detection of propofol by an ion mobility spectrometry technology, so that the pretreatment method has a very good application prospect in the field of propofol detection.
Owner:LIANYING YUEZHI SCIENCE INSTRUMENTS (WUHAN) CO LTD

Volatile matter detection method for baijiu base liquor of different rounds and flavor difference analysis method for baijiu

The invention provides a volatile matter detection method for different rounds of baijiu base liquor and a flavor difference analysis method for baijiu. The volatile matter detection method for different rounds of baijiu base liquor comprises the following steps: S01, taking different rounds of baijiu base liquor, and correspondingly preparing a plurality of different rounds of baijiu samples by adopting a closed volatilization balance mode; s02, respectively detecting volatile matters in the plurality of different rounds of white spirit samples by adopting a gas chromatograph-ion mobility spectrometry combined instrument to obtain detection data, and S03, carrying out data processing and qualitative analysis on the detection data corresponding to the different rounds of white spirit samples in S20 by adopting VOCal software to obtain the volatile matters in the plurality of different rounds of white spirit samples. Two-dimensional spectrograms of the volatile matters in the white spirit samples in different rounds, difference spectrograms of the volatile matters in the white spirit samples in different rounds and fingerprint spectrums of the volatile matters in the white spirit samples in different rounds are obtained. Complex volatile component information is presented in the form of visual images and data, the visualization degree is high, identification of different rounds of base liquor of Baijiu is facilitated, and rapid detection of flavor quality of different rounds of base liquor is realized.
Owner:GUIZHOU MOUTAI WINERY GRP XIJIU CO LTD +1

Data processing method and device of ion mobility spectrometry, and electronic equipment

The application discloses a data processing method and device of ion mobility spectrometry and electronic equipment. The method comprises the following steps: removing pseudo characteristic peaks in a target spectrum to obtain target characteristic peaks, wherein the target spectrum comprises a plurality of pseudo characteristic peaks and a plurality of target characteristic peaks; performing region growing according to the target characteristic peaks to determine a plurality of sequences, wherein the plurality of target characteristic peaks in the same sequence belong to the same substance, and one target characteristic peak corresponds to one sequence. The problem that the efficiency is low and the accuracy is poor when the ion mobility spectrometry is used for substance identification in the related art is solved.
Owner:SUZHOU WEIMU INTELLIGENT SYST CO LTD

De-solvation transmission-type desorption electrospray low-pressure ion mobility spectrometry

The invention relates to a transmission desorption electrospray low-pressure ion mobility spectrometry which comprises a transmission desorption electrospray ion source, an interface electrode and a low-pressure ion migration tube, the interface electrode is a metal sheet electrode with a through hole in the center, and the transmission desorption electrospray ion source is connected with the low-pressure ion migration tube through the interface electrode. The ion mobility spectrometry can realize efficient desorption spray ionization of substances difficult to volatilize in the detection process, the sample detection process is simplified, the working air pressure is lower than the atmospheric pressure, the detection sensitivity can be improved, furthermore, the ion mobility spectrometry is provided with a desolvation area and is combined with desolvation gas, the detection sensitivity can be further improved, and the detection accuracy is improved. High-sensitivity detection of anesthetic drugs such as propofol, etomidate, fentanyl and the like in blood can be realized through transmission-type desorption electrospray and low-pressure ion mobility spectrometry.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Ion fragmentation device

The invention relates to the field of mass spectrometry and ion mobility spectrometry, more specifically, to ion fragmentation in a collision cell. An ion fragmentation device comprising an ion transmission channel having an inlet end and an outlet end, the channel being delimited by surfaces on which radiofrequency and / or direct current electrodes are arranged, said electrodes generating a travelling wave field that directs ions towards the outlet end of the channel, wherein in the middle part of the device an electrode is provided, said electrode being configured to fragment and thermalize ions, and said electrode being different from other electrodes arranged on the rest of the device in terms of power supply mode and / or geometry. The technical effect of the invention is to increase fragmentation efficiency, ensure efficient ion transmission through all parts of the CID cell, reduce ion losses in the CID cell, increase analytical sensitivity; reduce ion packet broadening over time, reduce pressure in adjacent chambers of the mass spectrometer, thus allowing the use of pumps with lower pumping speed.
Owner:IONOSCOPE LLC

Fruit spice detection method and device based on gas chromatography-ion mobility spectrometry algorithm

The invention provides a fruit spice detection method and device based on a gas chromatography-ion mobility spectrometry algorithm, and can be applied to the technical field of fruit spice detection. The method comprises the following steps: performing fingerprint extraction on to-be-detected fruit flavor data based on a gas chromatography-ion mobility spectrometry algorithm to obtain a fingerprint; detecting the fingerprint spectrum by using a detection model to obtain a plurality of target volatile components; the multiple target volatile components, preset signal peak difference data and the volatile component markers are analyzed, fruits corresponding to the to-be-detected fruit flavor data are obtained, and the preset signal peak difference data represent sample signal peak data differences of different fruits for the preset volatile components; the volatile component marker is obtained by screening from the plurality of preset volatile components based on a preset projection variable importance threshold and the respective projection variable importance of the plurality of preset volatile components.
Owner:CHINA TOBACCO HUNAN IND CORP

Structural analysis of ionised molecules

An ion mobility spectrometry method is described comprising: providing a sample; generating molecular ions from the sample; separating the molecular ions according to their mobility characteristics; fragmenting at least some of the separated molecular ions to form sub-molecular fragment ions in a fragmentation zone; separating at least some of the fragment ions according to their mobility characteristics; wherein the separation and fragmentation steps are performed at a pressure of at least 50 mbar; detecting at least some of the separated fragment ions; and identifying at least one molecular ion based on its mobility characteristics and / or the mobility characteristics of at least one detected fragment ion.
Owner:THERMO FISHER SCI BREMEN

A rapid enrichment device for stirred silicone rubber filaments

This invention relates to the field of environmental analysis and testing technology. Addressing the problems of limited specific surface area, uneven mass transfer during stirring, and low desorption efficiency in existing membrane or tubular enrichers, it provides a rapid enricher using a stirred silicone rubber filament bundle. This enricher consists of 2-300 silicone rubber filaments bound into a bundle by a fixed head, connected to an electric drill via a connecting rod, and can be rotated and stirred in water samples at 100-3000 rpm. After enrichment, the bundle is placed in a thermal desorption container, where organic matter is desorbed by heating and then detected by ion mobility spectrometry along with the carrier gas. Compared to membrane / tubular structures, the filament bundle has a larger specific surface area, stronger turbulence during stirring, and effectively improved enrichment efficiency. Furthermore, the filament bundle is flexible and not easily broken, making it suitable for rapid on-site detection of complex matrix water and air samples.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Integrated migration tube based on PCB thermocompression bonding process

The integrated migration tube is characterized in that a copper-clad plate, a prepreg and an FR4 base material are stacked and hot-pressed into a composite base material according to a symmetrical structure, a cylindrical migration channel is machined through CNC, and a voltage division circuit, an ion gate, a shielding grid mesh, a Faraday disc detector and a shielding function are integrated. The integrated migration tube based on the PCB thermocompression bonding technology is compact in size, light in weight and high in batch precision, solves the problems that a traditional migration tube is low in integration level, large in size and poor in consistency, improves the analysis and recognition capacity of an ion mobility spectrometry, and is suitable for a high-performance migration spectrometer.
Owner:YINGKOU SHIJI ELECTRONICS INSTR CO LTD

Declustering ion guide

A method of mass spectrometry and / or ion mobility spectrometry, comprising: providing an ion director including a plurality of electrodes and having a background gas in the ion director; applying an RF voltage to the electrodes of the ion director to radially confine ions within the ion director; transporting a cluster of analyte ions and adduct substances into the ion director; in a first mode, applying one or more AC voltages to the ion director to oscillate the clusters such that the clusters collide with molecules of the background gas and cause adduct substances in the clusters to separate from the analyte ions, wherein the one or more AC voltages have an amplitude and / or frequency different from that of the RF voltage; and (i) changing the velocity at which the clusters are propelled along the ion director during the first mode; and / or (ii) changing the amplitude and / or frequency of the one or more AC voltages as the clusters travel along the ion director.
Owner:MICROMASS UK LTD

A high-sensitivity detection device based on gas phase ion mobility spectrometry

The present application relates to the technical fields of gas phase ion mobility spectrometry application, and mainly relates to a high-sensitivity detection device based on gas phase ion mobility spectrometry, which comprises a detection device body, an air inlet component arranged on one side of the detection device body, a filter cartridge fixed on one side of the detection device body, an insertion tube fixed in the filter cartridge, a gas guide component installed in the insertion tube, a rotating ring rotatably sleeved on the outside of the insertion tube, a partition plate fixed on the outside of the rotating ring, a filter part installed on the rotating ring, a movable insertion part installed on the insertion tube and connected with the filter part, and the movable insertion part being in communication with the air inlet component and the gas guide component. The filter device of the conventional instrument is optimized, a plurality of filter parts are arranged on the outside of the rotating ring, and the movable insertion part is used for docking, so that when a single filter part is replaced due to overload filtering, the single filter part can be conveniently disassembled without stopping the instrument, and the detection efficiency is improved when a large number of products are detected.
Owner:SHANDONG MEASUREMENT SCI RES INST

Method for real-time detection of volatile substances in rear nasal cavity beverage wine

The invention belongs to the technical field of detection and analysis, and particularly relates to a method for real-time detection of volatile substances in rear nasal cavity beverage wine. In order to accurately capture and analyze the change of volatile compounds in nasal exhaled air after drinking, the invention provides a method for realizing real-time detection of the volatile substances in the post-nasal beverage wine by combining direct sample injection with a gas chromatography-ion mobility spectrometry (GC-IMS) technology. By optimizing the alcohol content, the sipping amount, the sipping time, the expiration sample and the collection method, the release and detection effects of the volatile substances are further enhanced, and the detection sensitivity and the comprehensiveness of aroma analysis are improved. The detection method does not need a complicated sample pretreatment process, can effectively separate and quantitatively analyze complicated volatile compounds under specific chromatography and mass spectrometry, can quickly and reliably detect volatile substances in the nasal cavity, is suitable for dynamic monitoring of aroma after drinking, and provides a scientific basis for product development and sensory research.
Owner:LUZHOU LAOJIAO CO LTD +1

Method for rapidly identifying rose flower cakes from different producing areas

The invention discloses a method for quickly identifying rose flower cakes from different producing areas, which comprises the following steps: detecting volatile components of the rose flower cakes by adopting a headspace gas phase-ion mobility spectrometry technology to obtain GC-IMS sample data, and carrying out statistical analysis on the GC-IMS sample data through VOCal analysis software, a Report plug-in and a Galley Plot plug-in of an instrument, the GC-IMS fingerprint spectrums of the volatile aroma components of the rose flower cakes from different producing areas are obtained, so that the rose flower cakes are rapidly identified. According to the method, the GC-IMS technology is applied to carry out collection and trace analysis on the complex volatile substances in the rose flower cakes from different producing areas, comprehensive fingerprint information is provided for identification of the rose flower cakes, rapid and accurate distinguishing of the rose flower cakes from different producing areas is achieved, compared with a traditional analysis method, the method is simple and effective, consumed time is greatly shortened, and the method is suitable for large-scale popularization and application. The method has high sensitivity, and provides theoretical basis and data support for rapid identification of rose flower cakes from different producing areas.
Owner:LINYI UNIVERSITY

Oriented fermentation and quality control method for sour bamboo shoots based on organic acid pretreatment and multi-platform detection

The invention discloses a sour bamboo shoot directional fermentation and quality control method based on organic acid pretreatment and multi-platform detection. Firstly, lactic acid, acetic acid or an organic acid mixed by the lactic acid and the acetic acid is applied to a sour bamboo shoot raw material for initial stress before fermentation, and anaerobic fermentation is performed under a liquid sealing condition, so that the flora takeover time is remarkably shortened, and target lactic acid bacteria are enriched. Secondly, multi-pretreatment is carried out, gas chromatography-mass spectrometry and gas chromatography-ion mobility spectrometry double-platform detection is combined, and polar and non-polar flavor compounds are comprehensively covered. And finally, inputting detection data into a random forest, a support vector machine, OPLS-DA and other multi-algorithm models for cross screening, locking a robust flavor marker, and taking a p-cresol concentration curve as a quality release index. According to the method, the detection rate of the flavor compounds and the accuracy rate (greater than or equal to 95%) of the discrimination model can be remarkably improved, and an operable new method is provided for standardized production and rapid quality control of sour bamboo shoots and other plant fermented foods.
Owner:GUANGXI FORESTRY RES INST

De-clustering ion guide

A method of mass and / or ion mobility spectrometry comprising: providing an ion guide comprising a plurality of electrodes and having a background gas therein; applying an RF voltage to electrodes of the ion guide for radially confining ions therein; transmitting clusters of analyte ions and adduct species into the ion guide; applying, in a first mode, one or more AC voltage to the ion guide so as to oscillate the clusters such that they collide with molecules of the background gas and cause adduct species in the clusters to detach from the analyte ions, wherein the one or more AC voltage has a different amplitude and / or frequency to that of said RF voltage; and (i) varying the speed with which the clusters are urged along the ion guide during the first mode; and / or (ii) varying the amplitude and / or frequency of the one or more AC voltage as the clusters travel along the ion guide.
Owner:MICROMASS UK LTD

Tandem-trapped ion mobility spectrometry with microarray and biosensor

Disclosed is an analytical platform for profiling and functional analysis of proteomes, which can unveil new biological insights potentially useful for instigating novel therapeutic interventions. The disclosed analytical platform for proteome profiling is constructed by integrating plasmonic biosensor microarrays with tandem-ion mobility spectrometry. The disclosed analytical platform can separate, identify, and characterize highly similar proteoforms as well as low abundance proteoforms from plasma or other samples.
Owner:FLORIDA STATE UNIV RES FOUND INC