122 results about "Ion-mobility spectrometry" patented technology

A method of separating ions based on mobility is provided. The method involves receiving ions by an ion mobility spectrometry device having a separation region, and causing the ions to travel through at least a portion of the separation region in a first direction along a path and separate based on ion mobility. The method further involves causing the separated ions to maintain a relative degree of separation therebetween and travel in a second direction along the path while maintaining the relative degree of separation therebetween. The second direction being opposite to the first direction. The ions are then caused to travel in the first direction along the path a second time to further separate the ions based on ion mobility. An ion mobility spectrometry device performing the foregoing method is also provided.

The invention discloses a method for researching a polyolefin resin odor compound based on a headspace-gas chromatography-ion mobility spectrometry technology. The method is specifically implemented according to the following steps: step 1, carrying out headspace-gas chromatography-ion mobility spectrometry detection on polyolefin resin; step 2, extracting signal peaks of volatile compounds of different brands of resin through software LAV to construct a fingerprint spectrum; step 3, carrying out qualitative analysis processing on the signal peak of the area selected in the step 2 through GC-IMS Library Search Software qualitative software, and carrying out qualitative analysis processing on the signal peak of the area selected in the step 2 through GC-IMS Library Search Software qualitative software; step 4, taking the signal intensity of each compound in the odor compound fingerprint as a basis for comparing odor substances of resins with different brands, the GC-IMS technology is applied to odor analysis of related materials such as polyolefin resins with various brands, sample pretreatment is simple, complex pretreatment is not needed, the detection period is short, and the detection accuracy is high. Compared with the prior art, the method has the advantages of high sensitivity, resolution and resolution, and can compare and analyze the difference of odor compounds of different samples through the obtained fingerprint spectrum, carry out visual monitoring, and reduce the difficulty of difference analysis of different samples.

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.

The application discloses a container explosive non-opening box intelligent checking device based on ion mobility spectrometry, which comprises a connecting outer frame, a hydraulic cylinder is internally installed in the connecting outer frame, a hydraulic pump is connected to one end of the hydraulic cylinder, and a first piston is movably connected in the hydraulic cylinder. The ion mobility spectrometer and a separately designed collecting device are integrated into one equipment, a user carries the equipment by means of shoulder carrying, and a handle is equipped to facilitate holding. The air suction pipe is placed at the ventilation position of the container, the threaded rod and the first piston are driven to move transversely by hydraulic oil, the sample is pushed to the ion mobility spectrometer for analysis and detection, before the next sample test, the threaded rod is driven by the hydraulic oil to drive the polishing blade to rotate in the air suction pipe, the internal powder is scraped, the transverse thrust generated by the piston ring can extrude the gas in the air suction pipe, and thus the whole cleaning process is completed, the residues after each detection are greatly reduced, and the accuracy of the next extraction detection is avoided.

The application discloses a pet food palatability evaluation method based on gas chromatography-ion mobility spectrometry (GC-IMS) and a prediction model construction method, and belongs to the technical field of pet food quality analysis. The application aims at the problems of the existing palatability evaluation, such as strong subjectivity, long cycle and lack of standardized model, and adopts headspace-GC-IMS technology to rapidly detect volatile organic compounds (VOCs) in pet food, so as to obtain a VOCs fingerprint spectrum of the sample. In combination with standard samples with known palatability test results, key palatability markers are screened through orthogonal partial least squares discriminant analysis (OPLS-DA), and a palatability prediction model is established. The application first applies the GC-IMS technology to pet food palatability evaluation, realizes objectification, rapidness and standardization of detection, overcomes the subjectivity and low efficiency of traditional methods, and can provide reliable scientific basis for formula optimization, quality control and raw material screening of pet food.

The invention discloses a method for analyzing aroma components of cooking wine based on molecular docking and an odor activity value and application. According to the method, cooking wine aroma is taken as a research object, volatile substances are detected by gas chromatography-mass spectrometry (GC-MS) and headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS), and by combining with odor activity value (OAV) analysis, the combining capacity of aroma molecules and olfactory receptors is simulated through molecular docking, characteristic aroma compounds are screened, and the aroma of the cooking wine is detected. And finally, constructing a recombinant aroma model according to the characteristic aroma compounds, carrying out sensory evaluation, and evaluating the aroma similarity of the recombinant aroma model and the natural cooking wine sample to determine the characteristic aroma components of the cooking wine. The method can be used for analyzing aroma substances of cooking wine and performing standardized flavor management.

The invention relates to a reagent and a method for separation and identification of ofloxacin isomers, and relates to the technical field of analysis and test technologies and drug analysis, and the method comprises the following steps: mixing an isomer R / S ofloxacin sample with the reagent for separation and identification of ofloxacin isomers to prepare a mixed solution of R / S-OFLX-Vanco or R / S-OFLX-GM-metal ions; introducing the mixed solution into an ion source to generate compound ions, wherein the compound ions are monovalent positive ions of R / S-OFLX-Vanco or R / S-OFLX-GM-metal ions; and controlling the experimental device to measure the ion mobility spectrometry of the compound ions so as to obtain the enantiomeric structure information of R / S ofloxacin. The method has the effect of efficiently separating and quantitatively analyzing the enantiomer.

The present application relates to a kind of photoionization ion mobility spectrometry of fast switching combination reagent ion, including photoionization ion mobility spectrometry, reagent ion generation device, reagent molecule carrier gas is introduced to reagent molecule into the reaction zone of ion mobility spectrometry, different types of reagent ions can be obtained by switching different gas paths and reagent molecules in positive ion mode, and the reagent ions in conventional gas flow mode are mainly (C3H6O)2H + , after switching combination gas path device, new hydrate cluster reagent ion H3O (H2O) n + Is generated by the regulation of acetone and water reagent molecule, and the reactivity is higher, the sensitivity of target detection is higher, so that by switching different gas paths, the high sensitivity and high selectivity detection of target compound can be realized, such as the detection of exhaled air ammonia and atmospheric ammonia in complex matrix background, and any sample pretreatment process is not needed.

This invention discloses a method and application for detecting fentanyl and toluenethiazide using a microfluidic chip coupled with ion mobility spectrometry (IMS), belonging to the field of analytical chemistry. The method utilizes a microfluidic chip platform coupled with IMS for detection, specifically including the following steps: using a dual-channel microfluidic chip platform filled with adsorbent material, fentanyl and toluenethiazide are enriched in the sample to be tested; then, IMS is used to detect the enriched fentanyl and toluenethiazide in the sample. The detection method provided by this invention has high repeatability, minimizes operator exposure to drugs throughout the process, and greatly improves the accuracy and detection efficiency. Furthermore, the detection method provided by this invention has a short testing time, high sensitivity, and is automated and environmentally friendly, enabling rapid screening of fentanyl and toluenethiazide in multiple matrices.

The invention discloses an ion mobility spectrometry baseline correction method and device, and belongs to the technical field of ion mobility spectrometry. According to the method, the spatial continuity of a baseline is enhanced by constructing a regularization item containing multi-direction smooth constraints; and carrying out accurate calibration on a spectrum peak region by using a dynamically updated Gaussian template in an iteration process, and setting the spectrum peak region to be zero and the baseline region to be 1 in a weight matrix to realize effective separation of the spectrum peak and the baseline. According to the method, the non-uniform curved surface baseline can be accurately fitted, misjudgment of a weak peak and excessive inhibition of a strong peak in a traditional method are avoided, and the baseline correction precision and the spectrum peak retention rate are remarkably improved. Experiments show that the baseline root mean square error of the method on simulation data is less than 0.39, the spectrum peak retention rate exceeds 0.95, and the method is suitable for GC-IMS spectrogram processing of complex samples.

This application discloses a portable drug detection device and method, relating to the field of drug identification technology, with the main objective of addressing the problem of poor detection effectiveness in existing drug testing methods. It includes: a Raman spectroscopy component, an ion mobility spectrometry component, a processor, a power module, a display component, and a sample inlet module disposed on the ion mobility spectrometry component. The processor is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the display component, and is used to identify and process the spectra acquired by the Raman spectroscopy component and the ion mobility spectrometry component to obtain drug detection results. The power module is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the processor, and is used to provide power. The display component is used to display the drug detection results. The sample inlet module is used to insert sample test strips.

The present invention discloses a multi-channel ion transmission device for mass spectrometry and ion mobility spectrometry instruments; the device is mainly used in instruments such as ion mobility mass spectrometry to realize the effective transmission of ions in various groups of components and various levels of vacuum environment. The device includes two parts: a connecting fixture and an ion transmission component. The fixture is used to fix the ion transmission component, and the ion transmission component is a circuit board used to assemble an ion transmission channel. The circuit board includes components such as an ion gate, a traveling wave electrode, a DC protection electrode, and has been integrated on a circuit board. When in use, it is only necessary to place the two circuit boards in a mirror image and install them with fixtures. The present invention can realize functions such as multi-channel ion transmission, diversion, and guidance, and requires few parts and is simple to install, which greatly avoids the problems of system error amplification, difficult disassembly and assembly, long maintenance time, and high cost caused by multiple parts combination.

The invention provides a volatile gas detection method based on gas chromatography and ion mobility spectrometry, and belongs to the field of volatile gas detection. The method comprises the following steps: selectively capturing volatile gas generated in the petrochemical industry by using an MOFs functionalized adsorption tube; the interior of the MOFs functional adsorption tube is sequentially filled with a silver ion modified UIO-66 metal organic framework, copper tricarboxylate and a mixed layer of a poly (2, 6-diphenyl-p-phenylene ether) / graphitized carbon black composite adsorbent and a carbon molecular sieve adsorbent; the captured volatile gas is desorbed from the adsorption tube through a two-stage thermal desorption procedure; and introducing the desorbed volatile gas into a gas chromatograph-ion mobility spectrometry (GC-IMS) combined instrument, so as to measure the content of the volatile gas. Therefore, the detection efficiency and accuracy of the content of the petrochemical volatile gas are improved.

The present application relates to the technical field of pharmaceutical analysis, and specifically discloses a method for detecting the purity of doxycycline for injection. The present application mainly solves the problems caused by ion pair reagent and high-salt buffer in the existing chromatographic method, such as serious pollution of the system pipeline and the chromatographic column, difficulty in connecting with mass spectrometry for impurity structure identification, and insufficient separation degree of key polar impurities such as 4-epi doxycycline. The present application purifies the sample by physical dilution and filtration, and prepares uniform aerosol by ultrasonic atomization. The ion mobility spectrometry technology is adopted to realize the efficient separation of gas-phase ions under a weak electric field according to the difference in ion collision cross section (CCS) value, and the epimer which is difficult to distinguish by traditional methods can be excellently separated. The multi-modal sensor is used to synchronously collect ultraviolet, fluorescent and terahertz multi-dimensional optical signals. Finally, based on the intrinsic physical parameter database, the intelligent analysis is carried out by using the machine learning algorithm, and the qualitative and quantitative results are automatically output.

The present application relates to atmospheric pressure ion manipulation technology, specifically, the present application discloses a thermal desorption ionization reaction device, specifically, a thermal desorption ionization reaction device, comprising a stainless steel metal desorption ionization cavity, the metal desorption ionization cavity is a hollow circular cylinder with an open upper end and a closed lower end, an insulating cover for sealing the open upper end is arranged on the open upper end, and a gas and ion outlet is arranged in the middle of the insulating cover; the counter electrode and the electrode with holes are connected to the high-voltage output end of the high-voltage power supply and the ground electrode (or negative electrode) respectively. The voltage applied to the counter electrode and the electrode with holes is alternating current or direct current, and the voltage amplitude is 2000V. The present application improves the consistency and stability of batch production of thermal desorption ionization modules based on integrated design, reduces power consumption and processing cost, and is beneficial to the industrialization of mass spectrometry or ion mobility spectrometry.

The invention discloses a method for identifying high-quality pepper based on differential volatile compounds and application of the method, and relates to the technical field of food analysis and detection. The method comprises the following steps: carrying out qualitative analysis and quantitative analysis on the volatile compounds in the high-quality pepper based on the combination of ultrafast gas phase electronic nose analysis and headspace gas chromatography-ion mobility spectrometry analysis; analyzing the difference of the volatile compounds in the high-quality pepper by combining principal component analysis and partial least square discriminant analysis; the ultra-fast gas phase electronic nose analysis comprises first sample pretreatment and gas phase electronic nose analysis, and the headspace gas chromatography-ion mobility spectrometry analysis comprises second sample pretreatment, gas chromatography separation and ion mobility spectrometry analysis; the producing area of high-quality pepper is selected from Guizhou province. The method can quickly, comprehensively and systematically reveal flavor characteristics of different varieties of high-quality peppers, and provides a scientific theoretical basis for variety selection, dominant breeding, processing raw material optimization and flavor quality comprehensive evaluation of the high-quality peppers.

The fast recovery ion mobility spectrometry device comprises a migration tube, a diffusion permeable membrane, an ionization source, an ion gate and a Faraday disc are sequentially arranged in the migration tube from one end to the other end at intervals, the migration tube is provided with a pre-amplifier, a purging cavity is defined between the diffusion permeable membrane and the ionization source, and the Faraday disc is arranged in the purging cavity. A sample injection cavity is defined at one end, deviating from the ionization source, of the diffusion and permeation membrane, an ionization cavity is defined between the ionization source and the ion gate, a migration cavity is defined between the ion gate and the Faraday disc, and the migration pipe is connected with a gas supply pipe which is used for conveying clean gas to the sample injection cavity and the purging cavity. Gas purifying and conveying systems at the two ends of the diffusion and permeation membrane are purged; the fast-recovery ion mobility spectrometry device comprises the migration tube, the structural design is reasonable, redundant measured substances on the two sides of the diffusion and permeation membrane can be rapidly cleaned at the same time, and therefore the ion mobility spectrometry device is helped to rapidly recover the usable state.

The invention discloses a nuclear biochemical monitoring system and method, the system comprises a nuclear radiation detection module, a chemical toxic agent detection module, a biological factor detection module, an intelligent central control unit, a monitoring terminal and a remote command platform, the nuclear radiation detection module adopts a Geiger tube sensor to detect alpha, beta, neutron and gamma rays; the chemical toxic agent detection module is used for detecting various chemical toxic agents based on an ion mobility spectrometry technology; the biological factor detection module adopts an investigation, acquisition and detection integrated system to monitor and preliminarily screen biological aerosol, the intelligent central control unit processes, studies and judges multi-source data through 5G / Beidou communication by using a data fusion algorithm, and the monitoring terminal receives and prompts a monitoring report and a disposal scheme. The remote command platform realizes data visualization, long-term storage, multi-path alarm and emergency disposal scheme generation and issuing; according to the invention, real-time, rapid and cooperative monitoring and intelligent grading response of nuclear, biological and chemical threat factors are realized.

The utility model provides a fixed Faraday disc device for receiving ion mobility spectrometry signals, which comprises a disc front insulating ring, a Faraday disc, a metal fixing disc, an insulating cylinder, a metal cylinder, an insulating pad, a Faraday disc shielding cylinder and a fixing bolt, the Faraday disc comprises a metal disc and a metal rod, the metal rod is inserted into the metal cylinder, the insulating cylinder is sleeved outside the metal cylinder, and the insulating pad is sleeved outside the metal cylinder. A hole allowing the insulating cylinder to pass through and a hole allowing the fixing bolt to pass through are formed in the middle of the metal fixing disc, blind holes allowing the fixing bolt to be installed are formed in the inner wall of the Faraday disc shielding cylinder, the metal fixing disc and the Faraday disc shielding cylinder are installed through the fixing bolt, and an insulating pad is arranged between the metal fixing disc and the Faraday disc shielding cylinder. The bottom end of the Faraday disc shielding cylinder is provided with a slot, the disc front insulating ring is connected with the slot, and one end of the metal fixing disc away from the Faraday disc is provided with a signal joint end. Reliable assembly of the Faraday disc, airtightness of the migration tube and smoothness of the drift gas channel can be realized, and stable receiving and transmission of signals are ensured.

The invention relates to the technical field of liquid chromatography / mass spectrometry analysis, and discloses a method for improving LC / MS analysis sensitivity, which is suitable for detecting trace lipid metabolites (containing isomeride) of a biological sample. The core technical scheme is as follows: a magnetic molecularly imprinted polymer-solid phase support liquid-liquid extraction secondary purification system is adopted to remove matrix impurities, a gradient mobile phase containing a composite additive is matched to optimize separation, and the detection specificity is improved by an ion mobility spectrometry-segmented selective ion monitoring combined mode; and a stable isotope internal standard is synchronously introduced to correct quantitative deviation. Experiments show that the LOD of the method is as low as 0.12-0.25 ng / mL, the matrix effect is smaller than or equal to 5%, the separation degree and the recovery rate are excellent, low-abundance metabolic marker differences can be accurately captured, and a support is provided for disease diagnosis and metabonomics research.

A data acquisition method and ion mobility spectrometry-mass spectrometer (100) capable of effectively adapting to DDA or DIA, the data acquisition method comprising a pre-acquisition step (S1), a parent ion selection step (S2) and a daughter ion acquisition step (S3), the pre-acquisition step (S1) obtaining an ion mobility spectrometry-mass spectrometry two-dimensional heat map, the daughter ion selection step (S2) obtaining a daughter ion two-dimensional heat map, and the daughter ion acquisition step (S3) obtaining a daughter ion two-dimensional heat map; in the parent ion selection step (S2), the ion mobility analyzer (2) is configured to be in a filtering mode, parent ions are selected according to the ion mobility spectrum-mass spectrum two-dimensional heat map, and the mobility selection range of the ion mobility analyzer (2) and the mass selection range of the quadrupole mass filter (3) are correspondingly set. The data acquisition method solves the problems that an existing data acquisition method is limited in dynamic range and low in scanning efficiency.

The invention discloses a method for detecting an odor compound in a polyolefin resin additive. The method is specifically implemented according to the following steps: step 1, carrying out headspace-gas chromatography-ion mobility spectrometry detection on a polyolefin resin additive sample; step 2, extracting signal peaks of volatile compounds of different types of assistants through software LAV to construct a fingerprint spectrum; step 3, carrying out qualitative analysis processing on the signal peak selected in the step 2 through GC-IMS Library Search Software qualitative software, and carrying out qualitative analysis processing on the signal peak selected in the step 2 through GC-IMS Library Search Software qualitative software; and 4, taking the signal intensity of each compound in the odor compound fingerprint as a basis for comparing different types of additive odor substances. According to the invention, the volatile odor substances in different models of polyolefin resin aids can be qualitatively analyzed, and the difference of the volatile odor substances in different models of aids can be quickly analyzed and compared, so that the odor compounds can be visually monitored.

The application relates to a device and a method for improving ion mobility spectrum receiving signals, which comprise a Faraday disc, an insulating column, a Faraday disc shielding cylinder, a disc front insulating ring and an insulating nut, the Faraday disc comprises a metal disc and a metal rod, the metal rod is inserted into the hollow insulating column, an outer thread matched with the insulating nut is arranged on the metal rod, and a signal needle groove is arranged at the end of the metal rod far from the metal disc; one end of the hollow insulating column is inserted into the Faraday disc shielding cylinder, and the other end insulates the Faraday disc from the Faraday disc shielding cylinder; a gas hole is arranged on the Faraday disc shielding cylinder, a mounting groove is arranged on the bottom surface of the Faraday disc shielding cylinder, the metal disc can be mounted in the disc front insulating ring, and a protrusion matched with the mounting groove is arranged on the top surface of the disc front insulating ring. Through the structural design between the Faraday disc and the disc front insulating ring, the consistency of the end surface distance between the Faraday disc and the disc front insulating ring is ensured, and the strength, reliability and consistency of the transmission signals are improved.

A method of separating ions based on mobility is provided. The method involves receiving ions by an ion mobility spectrometry device having a separation region, and causing the ions to travel through at least a portion of the separation region in a first direction along a path and separate based on ion mobility. The method further involves causing the separated ions to maintain a relative degree of separation therebetween and travel in a second direction along the path while maintaining the relative degree of separation therebetween. The second direction being opposite to the first direction. The ions are then caused to travel in the first direction along the path a second time to further separate the ions based on ion mobility. An ion mobility spectrometry device performing the foregoing method is also provided.

The present invention belongs to the technical fields of mass spectrometry and ion mobility spectrometry analysis, and specifically relates to a modular assembled ion transmission device; the main ion transmission components of the device are all composed of modular printed circuit boards. The single body is a rectangular cube assembled from single-chip printed circuit boards. The single-chip printed circuit board is a base circuit board, which is a hollow cuboid with the cavity serving as the ion transmission channel. Multiple sets of radio frequency and direct current electrodes are drawn on the inside of the rectangle to form a pseudopotential field to guide the direction of ion propagation. Gate electrodes are provided at both ends to block the ion path or guide ions into the channel in a specified direction. Through the reuse of transmission modules, the ion transmission channel can be freely derived and assembled in six directions: up, down, left, right, front, and back, and ions can be transmitted along any channel direction. The device uses few parts, has low manufacturing costs, and is simple to install and maintain.

The invention relates to a fish species and cooking time classification and feature marker identification method and system based on an in-situ GC-IMS image. The method comprises the following steps: collecting two-dimensional spectrograms of volatile compounds of different fish meat at different cooking times by using gas chromatography-ion mobility spectrometry equipment, and dividing the two-dimensional spectrograms into a fish meat category data set and a cooking time data set after preprocessing; training based on the fish meat category data set to obtain a fish species classification prediction model; training by using a ResNet50 model based on the cooking time data set to obtain a fish cooking time classification prediction model; and positioning a key region of model decision by using a gradient weighted classification activation map, carrying out qualitative analysis on a compound corresponding to the key region, and determining a characteristic difference compound as a marker. The two classification prediction models can realize high-precision classification of fish types and cooking time; on the basis of the two trained models, the characteristic difference compounds can be quickly positioned and identified by using a gradient weighted classification activation map.

The invention relates to the technical field of biochemical detection, in particular to a pretreatment method of a propofol-containing sample, a propofol detection method and a kit. The pretreatment method of the propofol-containing sample comprises the following steps: providing the propofol-containing sample; the method comprises the following steps: adding porous polymer lipophilic magnetic beads into a sample, carrying out adsorption treatment, and then carrying out leaching treatment by using water and a methanol solution in sequence to obtain a propofol-magnetic bead compound; and eluting the propofol-magnetic bead compound by using an ammonia water methanol solution to obtain a sample to be detected. The pretreatment method provided by the invention is simple in process and low in cost, the to-be-detected sample containing propofol can be efficiently obtained, and the to-be-detected sample containing propofol can be subsequently used for high-sensitivity detection of propofol by an ion mobility spectrometry technology, so that the pretreatment method has a very good application prospect in the field of propofol detection.