181 results about "Ion-mobility spectrometry" patented technology

A method of separating ions based on mobility is provided. The method involves receiving ions by an ion mobility spectrometry device having a separation region, and causing the ions to travel through at least a portion of the separation region in a first direction along a path and separate based on ion mobility. The method further involves causing the separated ions to maintain a relative degree of separation therebetween and travel in a second direction along the path while maintaining the relative degree of separation therebetween. The second direction being opposite to the first direction. The ions are then caused to travel in the first direction along the path a second time to further separate the ions based on ion mobility. An ion mobility spectrometry device performing the foregoing method is also provided.

The invention relates to the technical field of food detection, in particular to a GC-IMS-based food freshness detection method, device and equipment, and the method comprises the following steps: obtaining headspace sampling gas of a to-be-detected food sample; according to the type of the to-be-detected food sample, automatically matching preset chromatographic conditions and ion mobility spectrometry conditions from a graded food type database; the headspace sampling gas is injected into GC-IMS, analysis is carried out based on matched chromatographic conditions and ion mobility spectrometry conditions, and a volatile organic compound fingerprint spectrum of the sample is obtained; and extracting preset key feature information from the fingerprint spectrum, and inputting the key feature information into a food freshness evaluation model to obtain a freshness evaluation result of the to-be-detected food sample. Therefore, the problems that in the prior art, detection parameter curing lacks adaptability, key feature analysis is not accurate, and model prediction accuracy is insufficient are solved.

The invention discloses a method for researching a polyolefin resin odor compound based on a headspace-gas chromatography-ion mobility spectrometry technology. The method is specifically implemented according to the following steps: step 1, carrying out headspace-gas chromatography-ion mobility spectrometry detection on polyolefin resin; step 2, extracting signal peaks of volatile compounds of different brands of resin through software LAV to construct a fingerprint spectrum; step 3, carrying out qualitative analysis processing on the signal peak of the area selected in the step 2 through GC-IMS Library Search Software qualitative software, and carrying out qualitative analysis processing on the signal peak of the area selected in the step 2 through GC-IMS Library Search Software qualitative software; step 4, taking the signal intensity of each compound in the odor compound fingerprint as a basis for comparing odor substances of resins with different brands, the GC-IMS technology is applied to odor analysis of related materials such as polyolefin resins with various brands, sample pretreatment is simple, complex pretreatment is not needed, the detection period is short, and the detection accuracy is high. Compared with the prior art, the method has the advantages of high sensitivity, resolution and resolution, and can compare and analyze the difference of odor compounds of different samples through the obtained fingerprint spectrum, carry out visual monitoring, and reduce the difficulty of difference analysis of different samples.

The invention relates to a cherry tomato storage period evaluation method and application, and belongs to the technical field of analysis and detection. The method for evaluating the storage period of the cherry tomatoes comprises the following steps: acquiring a cherry tomato sample; loading into a headspace bottle and incubating to obtain a headspace gas; carrying out headspace-gas chromatography-ion mobility spectrometry detection; vOCal analysis software is adopted for data collection; carrying out qualitative analysis on the volatile components by adopting a database; a cherry tomato classification model is constructed by adopting a multivariate statistics method, so that cherry tomato samples in different storage periods are classified. The evaluation method disclosed by the invention can be used for monitoring, classifying and judging the change of the volatile components of the cherry tomato samples under different storage conditions, and has the characteristics of high throughput, fast response, good repeatability, high accuracy and strong analysis capability.

A method of analysis using mass and / or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and / or ion mobility analysing and / or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

The invention belongs to the technical field of component detection, and relates to a three-state ion gate and a Hadamard transform ion mobility spectrometer. The three-state ion gate is arranged in the Hadamard transform ion mobility spectrometer and comprises a first grid mesh, a second grid mesh and a third grid mesh which are sequentially and separately arranged in the direction from a reaction region to a drift region; the grid voltage regulation and control module is used for controlling the voltage of the second grid to be larger than the voltage of the third grid and smaller than the voltage of the first grid within a first preset time when the modulation signal output by the spectral modulation Hadamard transform gating unit is a first level signal; when the modulation signal is converted from the first level signal to the second level signal, controlling the voltage of the second grid mesh to be greater than the voltage of the first grid mesh and the voltage of the third grid mesh within a second preset time; and when the modulation signal is a continuous second level signal, controlling the voltage of the second grid mesh to be smaller than the voltage of the first grid mesh and the third grid mesh. According to the scheme, the resolution and the signal-to-noise ratio of the ion mobility spectrometry obtained by the Hadamard transform example mobility spectrometer can be improved.

The invention provides a GC-IMS (Gas Chromatography-Insulated Mass Spectrometry)-based method for quickly identifying the vinasse preparation time and aroma difference of fish blocks, which comprises the following steps of: incubating fish meat samples in different vinasse preparation stages in a headspace sampling bottle to obtain an incubated sample, extracting a gas sample from the incubated sample by using a sampling needle, and analyzing the extracted gas sample by using a gas chromatography-mass spectrometry (GC-IMS); the extracted gas sample enters a headspace gas chromatography-ion mobility spectrometry combined instrument through a sample injection needle to be measured; detecting the to-be-detected fish block sample by using the same instrument condition; comparing and analyzing the to-be-detected fish blocks and the fish blocks in different vinasse processing stages in the database to confirm the vinasse processing stages of the fish blocks; according to the method disclosed by the invention, the GC-IMS technology is applied to carry out collection and trace analysis on complex aroma substances in the fish blocks in different vinasse processing stages, relatively comprehensive fingerprint information is provided for quality control of the fish blocks, and the vinasse processing stages of the fish blocks are determined according to corresponding characteristic indexes and difference components of the fish blocks in different vinasse processing stages; and rapid and accurate quality confirmation of the fish blocks in different grain pickling stages is realized.

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.

The present invention relates to an ion mobility spectrometer, which at least has a first drift chamber and a first switchable ion gate for controllably transferring ions into the first drift chamber, wherein: the first ion gate is designed as a field-switching ion gate having at least a first counter electrode and a first injection electrode; wherein, a first ionization chamber is formed between the first counter electrode and the first injection electrode, and ions to be analyzed by ion mobility spectrometry can be fed from an ionization source into the first ionization chamber. The present invention also relates to an ion mobility spectrometer, which at least has a first drift chamber and a first switchable ion gate for controllably transferring ions into the first drift chamber, as well as a second drift chamber separated from the first drift chamber and a second switchable ion gate for controllably transferring ions into the second drift chamber. The present invention also relates to a method for analyzing a sample by ion mobility spectrometry using an ion mobility spectrometer, such as an ion mobility spectrometer of the aforementioned type, wherein, by means of an ionization source, ions to be analyzed are generated from the sample and provided in the ionization chamber of the ion mobility spectrometer.

The application discloses a container explosive non-opening box intelligent checking device based on ion mobility spectrometry, which comprises a connecting outer frame, a hydraulic cylinder is internally installed in the connecting outer frame, a hydraulic pump is connected to one end of the hydraulic cylinder, and a first piston is movably connected in the hydraulic cylinder. The ion mobility spectrometer and a separately designed collecting device are integrated into one equipment, a user carries the equipment by means of shoulder carrying, and a handle is equipped to facilitate holding. The air suction pipe is placed at the ventilation position of the container, the threaded rod and the first piston are driven to move transversely by hydraulic oil, the sample is pushed to the ion mobility spectrometer for analysis and detection, before the next sample test, the threaded rod is driven by the hydraulic oil to drive the polishing blade to rotate in the air suction pipe, the internal powder is scraped, the transverse thrust generated by the piston ring can extrude the gas in the air suction pipe, and thus the whole cleaning process is completed, the residues after each detection are greatly reduced, and the accuracy of the next extraction detection is avoided.

The application discloses a pet food palatability evaluation method based on gas chromatography-ion mobility spectrometry (GC-IMS) and a prediction model construction method, and belongs to the technical field of pet food quality analysis. The application aims at the problems of the existing palatability evaluation, such as strong subjectivity, long cycle and lack of standardized model, and adopts headspace-GC-IMS technology to rapidly detect volatile organic compounds (VOCs) in pet food, so as to obtain a VOCs fingerprint spectrum of the sample. In combination with standard samples with known palatability test results, key palatability markers are screened through orthogonal partial least squares discriminant analysis (OPLS-DA), and a palatability prediction model is established. The application first applies the GC-IMS technology to pet food palatability evaluation, realizes objectification, rapidness and standardization of detection, overcomes the subjectivity and low efficiency of traditional methods, and can provide reliable scientific basis for formula optimization, quality control and raw material screening of pet food.

The invention discloses a method for analyzing aroma components of cooking wine based on molecular docking and an odor activity value and application. According to the method, cooking wine aroma is taken as a research object, volatile substances are detected by gas chromatography-mass spectrometry (GC-MS) and headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS), and by combining with odor activity value (OAV) analysis, the combining capacity of aroma molecules and olfactory receptors is simulated through molecular docking, characteristic aroma compounds are screened, and the aroma of the cooking wine is detected. And finally, constructing a recombinant aroma model according to the characteristic aroma compounds, carrying out sensory evaluation, and evaluating the aroma similarity of the recombinant aroma model and the natural cooking wine sample to determine the characteristic aroma components of the cooking wine. The method can be used for analyzing aroma substances of cooking wine and performing standardized flavor management.

The invention relates to a reagent and a method for separation and identification of ofloxacin isomers, and relates to the technical field of analysis and test technologies and drug analysis, and the method comprises the following steps: mixing an isomer R / S ofloxacin sample with the reagent for separation and identification of ofloxacin isomers to prepare a mixed solution of R / S-OFLX-Vanco or R / S-OFLX-GM-metal ions; introducing the mixed solution into an ion source to generate compound ions, wherein the compound ions are monovalent positive ions of R / S-OFLX-Vanco or R / S-OFLX-GM-metal ions; and controlling the experimental device to measure the ion mobility spectrometry of the compound ions so as to obtain the enantiomeric structure information of R / S ofloxacin. The method has the effect of efficiently separating and quantitatively analyzing the enantiomer.

The present application relates to a kind of photoionization ion mobility spectrometry of fast switching combination reagent ion, including photoionization ion mobility spectrometry, reagent ion generation device, reagent molecule carrier gas is introduced to reagent molecule into the reaction zone of ion mobility spectrometry, different types of reagent ions can be obtained by switching different gas paths and reagent molecules in positive ion mode, and the reagent ions in conventional gas flow mode are mainly (C3H6O)2H + , after switching combination gas path device, new hydrate cluster reagent ion H3O (H2O) n + Is generated by the regulation of acetone and water reagent molecule, and the reactivity is higher, the sensitivity of target detection is higher, so that by switching different gas paths, the high sensitivity and high selectivity detection of target compound can be realized, such as the detection of exhaled air ammonia and atmospheric ammonia in complex matrix background, and any sample pretreatment process is not needed.

To relate to a mass spectrometry field and particularly to provide a method for determining a chemical structure of a lipid and an ion mobility-tandem mass spectrometer.SOLUTION: A method for determining a chemical structure of a lipid includes: an ionization step of ionizing a sample to obtain sample ions; an ion mobility-based separation step of separating target lipid ions from the sample ions, based on ion mobility; a first dissociation step of dissociating a target lipid ions with dissociation energy adjusted to break a first chemical bond of the target lipid ions; a mass-based selection step of selecting the target lipid ions, whose first chemical bond is broken, based on a mass number to obtain fragment ions; a second dissociation step of dissociating the fragment ions to at least break a second chemical bond of the fragment ions which has bond energy higher than the first chemical bond, to obtain diagnostic ions; and a mass analysis step of performing a mass analysis on the diagnostic ions.SELECTED DRAWING: Figure 1

This invention discloses a method and application for detecting fentanyl and toluenethiazide using a microfluidic chip coupled with ion mobility spectrometry (IMS), belonging to the field of analytical chemistry. The method utilizes a microfluidic chip platform coupled with IMS for detection, specifically including the following steps: using a dual-channel microfluidic chip platform filled with adsorbent material, fentanyl and toluenethiazide are enriched in the sample to be tested; then, IMS is used to detect the enriched fentanyl and toluenethiazide in the sample. The detection method provided by this invention has high repeatability, minimizes operator exposure to drugs throughout the process, and greatly improves the accuracy and detection efficiency. Furthermore, the detection method provided by this invention has a short testing time, high sensitivity, and is automated and environmentally friendly, enabling rapid screening of fentanyl and toluenethiazide in multiple matrices.

The invention discloses an ion mobility spectrometry baseline correction method and device, and belongs to the technical field of ion mobility spectrometry. According to the method, the spatial continuity of a baseline is enhanced by constructing a regularization item containing multi-direction smooth constraints; and carrying out accurate calibration on a spectrum peak region by using a dynamically updated Gaussian template in an iteration process, and setting the spectrum peak region to be zero and the baseline region to be 1 in a weight matrix to realize effective separation of the spectrum peak and the baseline. According to the method, the non-uniform curved surface baseline can be accurately fitted, misjudgment of a weak peak and excessive inhibition of a strong peak in a traditional method are avoided, and the baseline correction precision and the spectrum peak retention rate are remarkably improved. Experiments show that the baseline root mean square error of the method on simulation data is less than 0.39, the spectrum peak retention rate exceeds 0.95, and the method is suitable for GC-IMS spectrogram processing of complex samples.

This application discloses a portable drug detection device and method, relating to the field of drug identification technology, with the main objective of addressing the problem of poor detection effectiveness in existing drug testing methods. It includes: a Raman spectroscopy component, an ion mobility spectrometry component, a processor, a power module, a display component, and a sample inlet module disposed on the ion mobility spectrometry component. The processor is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the display component, and is used to identify and process the spectra acquired by the Raman spectroscopy component and the ion mobility spectrometry component to obtain drug detection results. The power module is electrically connected to the Raman spectroscopy component, the ion mobility spectrometry component, and the processor, and is used to provide power. The display component is used to display the drug detection results. The sample inlet module is used to insert sample test strips.

The present invention discloses a multi-channel ion transmission device for mass spectrometry and ion mobility spectrometry instruments; the device is mainly used in instruments such as ion mobility mass spectrometry to realize the effective transmission of ions in various groups of components and various levels of vacuum environment. The device includes two parts: a connecting fixture and an ion transmission component. The fixture is used to fix the ion transmission component, and the ion transmission component is a circuit board used to assemble an ion transmission channel. The circuit board includes components such as an ion gate, a traveling wave electrode, a DC protection electrode, and has been integrated on a circuit board. When in use, it is only necessary to place the two circuit boards in a mirror image and install them with fixtures. The present invention can realize functions such as multi-channel ion transmission, diversion, and guidance, and requires few parts and is simple to install, which greatly avoids the problems of system error amplification, difficult disassembly and assembly, long maintenance time, and high cost caused by multiple parts combination.

The present invention discloses an ion mobility spectrometry device using a dual-window ultraviolet lamp for ionization, which relates to the technical field of ion mobility spectrometry. The ionization source of the ion mobility spectrometry device is a dual-window ultraviolet lamp, and the dual-window ultraviolet lamp includes: a glass tube, a first ultraviolet window, a second ultraviolet window, and an excitation electrode. The first ultraviolet window and the second ultraviolet window are respectively arranged at both ends of the glass tube. The glass tube is filled with a working gas, and the excitation electrode is arranged on the outer wall of the glass tube. This solution realizes simultaneous photoionization of the analyte while only using one ultraviolet light source. The light intensities of the two ultraviolet windows can be synchronously kept consistent, improving the correlation of positive and negative ion mobility spectrometry, ensuring that the ionization efficiencies on both sides are close, and reducing the occupation of the lamp body on the volume of the ion mobility spectrometry device. And because only one lamp is driven, the energy consumption is reduced, and a set of drive circuits is reduced, reducing the necessary volume and weight of the device from the lamp and the circuit.

The invention provides a volatile gas detection method based on gas chromatography and ion mobility spectrometry, and belongs to the field of volatile gas detection. The method comprises the following steps: selectively capturing volatile gas generated in the petrochemical industry by using an MOFs functionalized adsorption tube; the interior of the MOFs functional adsorption tube is sequentially filled with a silver ion modified UIO-66 metal organic framework, copper tricarboxylate and a mixed layer of a poly (2, 6-diphenyl-p-phenylene ether) / graphitized carbon black composite adsorbent and a carbon molecular sieve adsorbent; the captured volatile gas is desorbed from the adsorption tube through a two-stage thermal desorption procedure; and introducing the desorbed volatile gas into a gas chromatograph-ion mobility spectrometry (GC-IMS) combined instrument, so as to measure the content of the volatile gas. Therefore, the detection efficiency and accuracy of the content of the petrochemical volatile gas are improved.

The present application relates to the technical field of pharmaceutical analysis, and specifically discloses a method for detecting the purity of doxycycline for injection. The present application mainly solves the problems caused by ion pair reagent and high-salt buffer in the existing chromatographic method, such as serious pollution of the system pipeline and the chromatographic column, difficulty in connecting with mass spectrometry for impurity structure identification, and insufficient separation degree of key polar impurities such as 4-epi doxycycline. The present application purifies the sample by physical dilution and filtration, and prepares uniform aerosol by ultrasonic atomization. The ion mobility spectrometry technology is adopted to realize the efficient separation of gas-phase ions under a weak electric field according to the difference in ion collision cross section (CCS) value, and the epimer which is difficult to distinguish by traditional methods can be excellently separated. The multi-modal sensor is used to synchronously collect ultraviolet, fluorescent and terahertz multi-dimensional optical signals. Finally, based on the intrinsic physical parameter database, the intelligent analysis is carried out by using the machine learning algorithm, and the qualitative and quantitative results are automatically output.

1. Name of the Design Product: Auxiliary Monitoring Ion Mobility Spectrometer. 2. Use of the Design Product: For auxiliary monitoring of ion mobility spectrometry analysis. 3. Design Key Points of the Design Product: Lies in the overall shape design. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective view.

The present application relates to atmospheric pressure ion manipulation technology, specifically, the present application discloses a thermal desorption ionization reaction device, specifically, a thermal desorption ionization reaction device, comprising a stainless steel metal desorption ionization cavity, the metal desorption ionization cavity is a hollow circular cylinder with an open upper end and a closed lower end, an insulating cover for sealing the open upper end is arranged on the open upper end, and a gas and ion outlet is arranged in the middle of the insulating cover; the counter electrode and the electrode with holes are connected to the high-voltage output end of the high-voltage power supply and the ground electrode (or negative electrode) respectively. The voltage applied to the counter electrode and the electrode with holes is alternating current or direct current, and the voltage amplitude is 2000V. The present application improves the consistency and stability of batch production of thermal desorption ionization modules based on integrated design, reduces power consumption and processing cost, and is beneficial to the industrialization of mass spectrometry or ion mobility spectrometry.

The invention discloses a method for identifying high-quality pepper based on differential volatile compounds and application of the method, and relates to the technical field of food analysis and detection. The method comprises the following steps: carrying out qualitative analysis and quantitative analysis on the volatile compounds in the high-quality pepper based on the combination of ultrafast gas phase electronic nose analysis and headspace gas chromatography-ion mobility spectrometry analysis; analyzing the difference of the volatile compounds in the high-quality pepper by combining principal component analysis and partial least square discriminant analysis; the ultra-fast gas phase electronic nose analysis comprises first sample pretreatment and gas phase electronic nose analysis, and the headspace gas chromatography-ion mobility spectrometry analysis comprises second sample pretreatment, gas chromatography separation and ion mobility spectrometry analysis; the producing area of high-quality pepper is selected from Guizhou province. The method can quickly, comprehensively and systematically reveal flavor characteristics of different varieties of high-quality peppers, and provides a scientific theoretical basis for variety selection, dominant breeding, processing raw material optimization and flavor quality comprehensive evaluation of the high-quality peppers.

According to the present invention, the gas chromatography-ion mobility spectrometry (GC-IMS) technology is adopted to analyze the types and the differences of the volatile components of the herba schizonepetae and the processed product so as to provide reference for the characterization and the accurate identification of the volatile components of the herba schizonepetae and the processed product, and the GC-IMS is adopted to analyze and identify the volatile components in the herba schizonepetae, the fried herba schizonepetae and the herba schizonepetae charcoal, the difference of volatile components of the herba schizonepetae, the fried herba schizonepetae and the herba schizonepetae charcoal is analyzed in combination with chemometrics, the GC-IMS technology and the chemometrics analysis method are researched and utilized, the different volatile organic compounds of the herba schizonepetae, the fried herba schizonepetae and the herba schizonepetae charcoal are screened out, and an idea is

The invention discloses an ion mobility spectrometry-based method for rapidly judging the authenticity of Tongzhou green tea, and belongs to the technical field of food quality detection. The method comprises the following steps: 1) establishing an ion mobility spectrometry detection method for aroma components of the Tongzhou green tea extracted by hot water; 2) collecting the aroma fingerprint spectrum of the Tongzhou tea leaves under different drying modes and extraction conditions; the method comprises the following steps of 1, establishing a fingerprint spectrum database of the characteristic aroma types of the Tongzhou tea leaves under different drying modes and extraction conditions, 2, distinguishing and identifying the Tongzhou green tea processed in different drying modes, 3, establishing a fingerprint spectrum database of the characteristic aroma types of the Tongzhou tea leaves under different drying modes and extraction conditions, and 4, distinguishing and identifying the Tongzhou green tea processed in different drying modes.

The fast recovery ion mobility spectrometry device comprises a migration tube, a diffusion permeable membrane, an ionization source, an ion gate and a Faraday disc are sequentially arranged in the migration tube from one end to the other end at intervals, the migration tube is provided with a pre-amplifier, a purging cavity is defined between the diffusion permeable membrane and the ionization source, and the Faraday disc is arranged in the purging cavity. A sample injection cavity is defined at one end, deviating from the ionization source, of the diffusion and permeation membrane, an ionization cavity is defined between the ionization source and the ion gate, a migration cavity is defined between the ion gate and the Faraday disc, and the migration pipe is connected with a gas supply pipe which is used for conveying clean gas to the sample injection cavity and the purging cavity. Gas purifying and conveying systems at the two ends of the diffusion and permeation membrane are purged; the fast-recovery ion mobility spectrometry device comprises the migration tube, the structural design is reasonable, redundant measured substances on the two sides of the diffusion and permeation membrane can be rapidly cleaned at the same time, and therefore the ion mobility spectrometry device is helped to rapidly recover the usable state.