113 results about "Neutral molecule" patented technology

The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection.

A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m / z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

The invention relates to a method and device for directly analyzing the generation of a sample and analyzing ions without pretreatment. The method comprises the following steps of: generating neutral molecules at atmospheric pressure; conveying the generated neutral molecules into a low-pressure area; and making the neutral molecules react with charged droplets sprayed from an electron spray needle point or photons emitted from a vacuum ultraviolet source in the low-pressure area for ionizing, wherein the ions generated in the process are converged and guided in an alternative electric field before being conveyed to a mass spectrograph or an ion migration spectrograph for further analyzing.

A mass spectrometer system includes a sample injection device defining a sample injection aperture. The system also includes an ion trap defining an ion outlet aperture. The ion trap is coupled to the sample injection device. The system further includes a detector positioned downstream of the ion outlet aperture. The system also includes an ion source coupled to the ion trap. The ion source is configured to ionize a sample injected into the ion trap and generate a plurality of ionized molecules within the ion trap. The ion trap is configured to maintain the plurality of ionized molecules therein while a plurality of neutral molecules migrate out of the ion trap until a predetermined pressure is attained in the ion trap.

A new ionization source named Surface Activated Chemical Ionization (SACI) has been discovered and used to improve the sensitivity of the mass spectrometer. According to this invention the ionization chamber of a mass spectrometer is heated and contains a physical new surface to improve the ionization process. The analyte neutral molecules that are present in gas phase are ionized on this surface. The surface can be made of various materials and may also chemically modified so to bind different molecules. This new ionization source is able to generate ions with high molecular weight and low charge, an essential new key feature of the invention so to improve sensitivity and reduce noise. The new device can be especially used for the analysis of proteins, peptides and other macromolecules. The new invention overcomes some of the well known and critical limitations of the Electrospray (ESI) and Matrix Assisted Laser Desorption Ionization (MALDI) mass spectrometric techniques.

The invention belongs to the technical field of mass spectrometry and particularly relates to a cascade mass spectrometry method performed in an ion trap mass analyzer. The cascade mass spectrometry method performed in the ion trap mass analyzer specifically comprises three stages of ion selective segregation, collision induction dissociation and mass scanning and analyzing. According to the cascade mass spectrometry method performed in the ion trap mass analyzer, in the stage of collision induction dissociation, by changing the period of a radio frequency signal, namely changing the frequency of radio-frequency voltage loaded on an ion trap, parent ions with a certain mass-to-charge ratio undergo resonance excitation so as to obtain energy. The high-energy ions which undergo resonance excitation collide with neutral molecules in the ion trap and are dissociated, outcome ions are generated, and the cascade mass spectrometry is achieved. The cascade mass spectrometry method performed in the ion trap mass analyzer has the advantages that only arrangement of software can be used for changing the scanning period of the stage of collision induction dissociation in order to achieve collision induction dissociation, and thus, an experiment device and a method of cascade mass spectrometry can be obviously simplified.

The present invention provides an electrochromic mirror including: a transparent substrate; a transparent electrode film which is formed on the transparent substrate and has conductivity; an electrochromic film which is formed on the transparent electrode film and can be colored by reduction; a light reflecting film which is formed on the electrochromic film and which hydrogen atoms or lithium atoms can permeate; a support substrate which has a conductive part having conductivity formed on at least one surface thereof; and an electrolytic solution containing at least hydrogen ions or lithium ions, and neutral molecules or negative ions which can be oxidized, wherein the transparent substrate is located close to the support substrate such that the conductive part faces the light reflecting film, and the electrolytic solution is enclosed between the light reflecting film and the conductive part.