487 results about "Ion trap" patented technology

Droplets or plugs within multiphase microfluidic systems have rapidly gained interest as a way to manipulate samples and chemical reactions on the femtoliter to microliter scale. Chemical analysis of the plugs remains a challenge. It has been discovered that nanoliter plugs of sample separated by air or oil can be analyzed by electrospray ionization mass spectrometry when pumped directly into a fused silica nanospray emitter nozzle. Using leu-enkephalin in methanol and 1% acetic acid in water (50:50 v:v) as a model sample, we found carry-over between plugs was <0.1% and relative standard deviation of signal for a series of plugs was 3%. Detection limits were 1 nM. Sample analysis rates of 0.8 Hz were achieved by pumping 13 nL samples separated by 3 mm long air gaps in a 75 μm inner diameter tube. Analysis rates were limited by the scan time of the ion trap mass spectrometer. The system provides a robust, rapid, and information-rich method for chemical analysis of sample in segmented flow systems.

An apparatus including a plurality of electrodes defining a trapping chamber of an ion trap, wherein at least one of the electrodes is a transparent electrode having at least a portion that is both optically transparent and electrically conductive; a controller connected to the plurality of electrodes, wherein the controller includes a memory containing computer readable instructions which, when executed, cause the controller to send control signals to the plurality of electrodes so that: the plurality of electrodes produce and maintain a trapping field in the trapping chamber, and the plurality of electrodes change the trapping field so that ions of a predetermined mass in the trapping chamber are selectively moved; and an optical detector oriented so that the portion of the transparent electrode that is both optically transparent and electrically conductive is between the optical detector and the trapping chamber.

A hybrid mass spectrometer has a branched ion path. A first ion path within the branched ion path operates as a triple quadrupole instrument having a mass selection device, collision cell, and first mass analyzer and provides information on a specific m/z ratio corresponding to ions of interest in a sample. A second ion path within the branched ion path includes a second mass analyzer in the form of an electrostatic trap or other ion trap device. A branched ion transfer device may provide the branched ion path and may include the collision cell. A controller actuates an ion path switch in the branched ion transfer device and diverts from the first ion path to the second ion path in response to a triggering event. Ions at or near the m/z ratio of interest are then analyzed in the trap to obtain more detailed information of a full spectrum.

An erasable programmable non-volatile memory cell encompasses an ion well; a first select transistor including a select gate, source/drain formed in the ion well, and a channel region formed between its source and drain; a first floating gate transistor having a drain, a source coupled to the drain of the first select transistor, a first floating gate channel region formed between its drain and source, and a common floating gate overlying the floating gate channel region; a second select transistor including a select gate, source/drain formed in the ion well, and a channel region formed between its source and drain; and a second floating gate transistor having a drain, a source coupled to the drain of the second select transistor, a second floating gate channel region formed between its drain and source, and the common floating gate overlying the second floating gate channel region.

A circuit is described for applying RF and AC voltages to the elements or electrodes of an ion trap or ion guide. The circuit includes an RF transformer having a primary winding and a secondary winding. The secondary winding includes at least two filars. A broadband transformer adapted to be connected to a source of AC voltage applies AC voltage across the low-voltage end of two of the filars. Another broadband transformer connected to the filars at the high-voltage end provides a combined RF and AC output for application to selected electrodes. Also described is a circuit employing a multi-filar RF transformer and broadband transformers for applying RF and AC voltages to spaced rods of a linear ion trap. Also described is a circuit employing a multi-filar RF transformer and broadband transformers for applying RF and AC voltages to the electrodes in each section of a linear ion trap of the type having a center section and end sections, and different DC voltages to the electrodes in the end sections.

A method for multiplexed analysis using ion mobility spectrometer in which the effectiveness and efficiency of the multiplexed method is optimized by automatically adjusting rates of passage of analyte materials through an IMS drift tube during operation of the system. This automatic adjustment is performed by the IMS instrument itself after determining the appropriate levels of adjustment according to the method of the present invention. In one example, the adjustment of the rates of passage for these materials is determined by quantifying the total number of analyte molecules delivered to the ion trap in a preselected period of time, comparing this number to the charge capacity of the ion trap, selecting a gate opening sequence; and implementing the selected gate opening sequence to obtain a preselected rate of analytes within said IMS drift tube.

A single-poly non-volatile memory cell that is fully compatible with nano-scale semiconductor manufacturing process is provided. The single-poly non-volatile memory cell includes an ion well, a gate formed on the ion well, a gate dielectric layer between the gate and the ion well, a dielectric stack layer on sidewalls of the gate, a source doping region and a drain doping region. The dielectric stack layer includes a first oxide layer deposited on the sidewalls of the gate and extends to the ion well, and a silicon nitride layer formed on the first oxide layer. The silicon nitride layer functions as a charge-trapping layer.

The invention relates to a large capacity linear ion well which can be applied on various analysis aims and an electrode processing method which realizes integration of high accuracy and precision processing and installing. The linear ion well includes an ion capture chamber, RF electrode, and DC electrode, wherein, RF electrode is comprised by plural parts thereby dividing the ion capture chamber into plural sub-regions, thus, plural mass spectrometry procedures can be realized. The RF electrode of the ion well can be made in an integration processing manner of processing nonmetallic substrate first and then coating a metallic membrane on the surface thereof, at last, removing the metallic membrane of insulation region according to the requirement of the sub-electrodes. The multipurpose large capacity linear ion well provides an implementation scheme having characters of high applicability, various uses, low cost, easy processing and installation for the development of ion well quality analyzer and mass spectrograph.

The application relates to an ion trap mass spectrometer. An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time- of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.

The invention relates to a circular ring ion trap and a circular ring ion trap array used for an ion storage device with ultra high capacity and a mass analyzer which is used for carrying out the separation and the detection according to the characteristics of an ion, such as the mass-to-charge ratio of the ion, and the like. The circular ring ion trap comprises an ion lead-in hole and an ion lead-out hole. Two parallel annular electrodes with flat hollow circular ring structures, and two cylindrical circular rings with different outside diameters and perpendicular to the flat annular electrodes form an inner and an outer boundary electrodes. The two flat annular electrodes are arranged in parallel and vertically, and share the same axis center with the two boundary electrodes; the boundary electrode with a small diameter is positioned on the inner side of the flat hollow annular electrodes; the boundary electrode with a large diameter is positioned on the outer side of the flat hollow annular electrodes; a gap or an insulating material is arranged in the boundary electrodes and the flat annular electrodes, so as to ensure the electric insulation among the electrodes; a high-frequency voltage signal is applied to the upper and the lower flat annular electrodes; the boundary electrodes are grounded or a DC voltage is applied to the boundary electrodes to form an ion storage area. Under the externally applied electric field, the ion is captured, stored, cooled or optionally discharged outside a trap.

Intensity data of the signals produced by an ion detector are sequentially stored in a data processor, with each piece of intensity data being associated with time t required for each of the various ions ejected from an ion trap to fly through a time-of-flight space and reach the ion detector. The data obtained within a time range T2 corresponding to a measurement mass range are extracted as profile data. The data obtained within either a time range T1 before the arrival of an ion having the smallest m/z value or a time range T3 after the arrival of an ion having the largest m/z value are extracted as noise component data. Various kinds of noise information such as the noise level or standard deviation are calculated from the noise component data. Based on this noise information, a noise component is removed from the profile data. For every mass scan cycle, the noise component data and profile data are almost simultaneously obtained. Therefore, even if the electrical noise from the ion detector changes with time, the noise can be properly removed with little influence from that change of the noise.

Tetrapolar pole for optimizing shape of field can be in use as pole type analyzer for mass of ion, ion trap type analyzer for mass of ion, linear ion trap, or ion guidance. The tetrapolar pole includes at least four RF electrodes parallel to z-axis of central axis of mass analyzer, and RF voltage of generating RF ion capture electric field. Here, RF electrodes are in structure of cylinder body. The cylindrical surface is locus drawn out by generating line L of electrode parallel to z-axis, and moving along the gauge line of electrode f(x,y)=0. The locus possesses form of piecewise function. Using a set of parallel plane through each boundary point, the invention parses x or y electrode into at least two thin layer. It is easy to be produced for the electrode possible to be parsed to multiple units of thin layer. Adjusting parameters of the thin layers can obtain optimized shape of tetrapolar field so as to improve analytical performance of tetrapolar mass analyzer.

The invention provides a novel series-parallel connection mass spectrum device system. The system comprises mass spectrum necessary basic subsystems, such as a set of quadrupole mass filter system, a special quadrupole rod/linear ion trap mass analyzer system, an ion guidance system, a quadrupole deflector, a hyperbolic quadrupole rod mass analyzer and ion counter system, a low air pressure linear ion trap mass spectrometer and electron multiplier system, a flight time mass spectrum system, a multi-path gas flow control system, a vacuum gauge, a multi-section differential motion vacuum system and the like. Furthermore, the invention provides a method for operating above systems to perform quantitative analysis in a triplet quadrupole rod mode, qualitative analysis in a quadrupole filtering medium combined high/low air pressure ion trap mode, and quick/high-mass precision analysis in a quadrupole filtering combined flight time mass spectrum mode on ultra-trace materials in a complex matrix, a method for utilizing an effective combination of three different mass analyzers to achieve optimal ion optical parameter adjustment and a method for performing high-precision qualitative and quantitative analysis on the ultra-trace materials.

A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion trap mass analyzer that accumulates the ions based on their mass to charge ratio. A surface is in cooperative relationship with the separator so that the separated molecules are soft landed onto the surface at different locations such that the collected molecules can be stored or further processed/analyzed.

An automatic gain control (AGC) technique and apparatus is introduced herein for any temporally non-uniform ion beam, such as, for example, an ion beam produced by a MALDI ion source so as to minimize space charge effects. The disclosed configurations and techniques can be achieved by using an ion optical gating element and applying a desired signal waveform (e.g., a square wave) having a predetermined duty cycle. The applied voltage amplitude of such a signal can be configured to switch between a voltage which fully transmits the ions, and a voltage which does not transmit any ions. The frequency is chosen to result in a period which is significantly lower than the smallest non-uniformity period. Techniques of the present invention can also be extended to methods of AGC which can use a single ion injection event from the ion source to avoid variations in ion numbers from an unstable ion source.

A HV MOS transistor device having a substrate, a gate, a source, a drain, a first ion well of a first conductive type disposed in the substrate, and a plurality of field plates disposed on the substrate is disclosed. The HV MOS transistor device further has a first doped region of a second conductive type positioned in the first ion well. Therefore, a first interface and a second interface between the first ion well and the first doped region are formed, and the first interface and the second interface are respectively positioned near the drain and the source. In addition, the first interface is positioned under a respective field plate to produce a smooth field distribution and to increase the breakdown voltage of the HV transistor device.

A vacuum ion trap includes a gastight processing enclosure and a permanent magnet defining a cavity and creating a directed magnetic field in the cavity, the enclosure being disposed inside the cavity and containing a confinement cell having at least two mutually parallel trapping electrodes perpendicular to the directed magnetic field, the trapping electrodes being connectable to a voltage generator. The trap includes at least one permanent magnet in the form of a hollow cylinder and structured with a Halbach cylinder type structure so as to generate the permanent magnetic field directed perpendicularly to the longitudinal axis of the cavity of the magnet. The trap is applicable in particular to Fourier transform mass spectrometry (FTICR).