237results about "Spectrometer circuit arrangements" patented technology

A power supply device applies a voltage to a quadrupole mass filter. The power supply device has a main substrate and a wave-detection substrate. The main substrate includes a detector. The wave-detection substrate includes a wave detector and an identifier. The wave detector detects an AC component of a voltage to be applied to the quadrupole mass filter as a wave-detection voltage. The identifier outputs identification information of the wave detector defined in correspondence with the configuration of a rectifying device of the wave detector. The detector detects identification information output by the identifier, and supplies the detected identification information to a corrector that corrects a deviation of voltage caused by a leakage current of the rectifying device.

Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.

An example system includes a set of multipole electrodes and an RF generator configured to selectively output a signal voltage at a first frequency or at a second frequency for driving the set of multipole electrodes. The system further includes a low-frequency transformer assembly and a high-frequency transformer assembly. The system further includes a switching circuit configured to connect the RF generator to: the low-frequency transformer assembly when the RF generator outputs the RF voltage at the first resonant frequency, the low-frequency transformer assembly configured to supply a first voltage based on the RF voltage to an output coupled to the set of multipole electrodes, or the high-frequency transformer assembly when the RF generator outputs the RF voltage at the second resonant frequency, the high-frequency transformer assembly configured to supply a second voltage based on the RF voltage to the output coupled to the set of multipole electrodes.

The invention provides an ion detection amplifier and an ion detection method, and belongs to the field of mass spectrometers. The ion detection amplifier provided by the invention comprises a primary amplification circuit used for receiving a current signal output by an ion detector; the load module is connected with the primary amplification circuit in parallel, and the load module comprises a plurality of feedback branches; the secondary amplification circuit is connected with the output end of the primary amplification circuit, is used for amplifying an output signal of the primary amplification circuit, and is provided with a plurality of secondary gain gears; the gain switching control circuit is respectively connected with the load module and the secondary amplification circuit; and the signal processing circuit is used for receiving an output signal of the secondary amplification circuit. According to the ion detection amplifier and the ion detection method provided by the invention, collection, amplification, switching and digital output of ion signals can be accurately and efficiently completed in a complex scene.

A system and method for controlling the flow of aerosols. In some embodiments, a system includes a fluid channel, an actuator, and an actuator drive circuit. The actuator and the actuator drive circuit may be configured to impart vibrations, to a wall of the fluid channel, which produce waves in a gas in the fluid channel and cause aerosols in the gas to be nonuniformly distributed across the interior of the fluid channel, the waves producing a pressure pattern including a plurality of nodes or a plurality of antinodes within the fluid channel.

To provide an impedance matching circuit using an insulated air core transformer, and a mass spectrometer including the same, to increase the measurement accuracy.SOLUTION: A mass spectrometer includes: a sample introduction part; an ionization part connected to the sample introduction part and including a plasma coil that ionizes a sample introduced from the sample introduction part; an RF power supply part that is electrically connected to the ionization part and that supplies RF power to the ionization part; an ion lens part that includes an extraction lens adjacent to the ionization part, and a guide lens configured to guide an ion beam extracted from the extraction lens; and a detection part that detects the ion beam. The RF power supply part includes an impedance matching circuit that controls a voltage due to an inductance component of the plasma coil.SELECTED DRAWING: Figure 1

An ion guide or ion trap that comprises a plurality of electrodes (102) is disclosed. The ion guide or ion trap includes a detector (205) that can detect light or particles (114) emitted from the ion guide or ion trap due to electrical breakdown, and a control circuit (111) that can control the ion guide or ion trap in response to the detector (205) detecting light or particles (114) emitted from the ion guide or ion trap.

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.

An amplifier circuit (101) is provided with: a first current source circuit (113) that outputs a predetermined amount of current to a first wiring (L1); a voltage amplifier circuit (110) that amplifies the voltage of the input signal; a first level shift circuit (111) which is connected between the first wiring (L1) and the output of the voltage amplifier circuit (110) and shifts the voltage of the signal output from the voltage amplifier circuit (110); a first voltage follower (117) that is connected to the first wiring (L1) and amplifies a signal in the first wiring (L1); and a first capacitor (210) connected between the first wiring (L1) and the output of the voltage amplifier circuit (110).

The present application discloses an ion trap radio frequency driving device, comprising: a sampling module, used to output a high-voltage signal of the ion trap radio frequency driving device, and to sample the high-voltage signal to obtain a sampling signal; a rectifying and filtering module, used to rectify and filter the sampling signal to obtain a DC voltage signal; a voltage source, used to provide a standard voltage reference signal; a proportional-integral controller, used to compare the DC voltage signal with the standard voltage reference signal to obtain a feedback signal; a radio frequency signal source, used to provide a local oscillator signal; a mixer, used to adjust the radio frequency output signal according to the local oscillator signal and the feedback signal to obtain a radio frequency stable signal; a power amplifier, used to amplify the radio frequency stable signal, and output a high-voltage signal through the sampling circuit, thereby ensuring a larger radio frequency voltage gain and a higher signal-to-noise ratio.

A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus includes, along a longitudinal direction, a first end cap electrode, a central electrode having an aperture, and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. Electric fields can be applied in a y-direction of the lateral plane across one or more planes perpendicular to the longitudinal axis to translocate and / or manipulate ion trajectories.

Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.

A radio frequency (RF) choke for use within a mass spectrometer comprises a bobbin having a hollow channel, a plurality of wire windings wound around the bobbin, each of the wire windings presenting a lattice winding pattern having a number of crossovers per turn of from about 1 to about 4, and a magnetic core disposed within the hollow channel of the bobbin. The RF choke exhibits an impedance in the range of from about 15 M ohms to about 150 M ohms with respect to an RF frequency generated by an RF voltage source within the range of from about 500 KHz to about 3 MHz, and a power dissipation equal to, or less than, about 3 W with respect to a peak-to-peak RF voltage of an RF voltage source of at least about 1 kV.

The invention belongs to the technical field of analytical instruments, and provides a flat plate type FAIMS analyzer, which comprises a separation area, an upper separation electrode, a lower separation electrode, a flat plate type FAIMS, a flat plate type FAIMS and a flat plate type FAIMS, the separation voltage signal source is used for outputting high-frequency asymmetric voltage; the first compensation voltage source is used for outputting negative compensation voltage, and the high-frequency asymmetric voltage and the negative compensation voltage are superposed and then applied to the upper separation electrode; the second compensation voltage source is used for applying the output positive compensation voltage to the lower separation electrode, the absolute value of the positive compensation voltage and the absolute value of the negative compensation voltage at the same moment are equal, and the positive compensation voltage and the negative compensation voltage enable the equal height of the center of the separation area to be kept in a zero potential state. The negative compensation voltage eliminates potential fluctuation caused by the positive compensation voltage in the center of the separation area, so that the center of the separation area is kept in a zero potential state, more target ions reach the detection area through the zero potential state of the center of the separation area, and therefore the FAIMS detection sensitivity is improved.

A charge detection mass spectrometer may include an ion source to generate ions, a mass spectrometer to separate the generated ions as a function of ion mass-to-charge ratio to produce beam of separated ions, an electrostatic linear ion trap (ELIT) including a charge detection cylinder disposed between a pair of coaxially aligned ion mirrors, and means for controlling a trajectory of the beam of separated ions entering the ELIT to cause the ions subsequently trapped in the ELIT to oscillate therein with different planar ion oscillation trajectories angularly offset from one another about the longitudinal axis with each extending along and crossing the longitudinal axis in each of the ion mirrors or with different cylindrical ion oscillation trajectories radially offset from one another about the longitudinal axis to form nested cylindrical trajectories each extending along the longitudinal axis.

According to one aspect of the present invention, a high-voltage power supply device outputs a high voltage of both positive and negative polarities in a switchable manner and includes: a first voltage generation unit; a second voltage generation unit; a first discharging diode connected to the first voltage generation unit; a second discharging diode connected to a the second voltage generation; a first output circuit connected including a first switch and a protective resistor connected in series to each other; a second output circuit including a second switch and a protective resistor connected in series to each other; an output capacitor connected in parallel to a load; a controller controlling the voltage generation units and opening / closing operations of the switches; limitation units configured to limit a time rate of change of a voltage between ends of the a respective switch.

A power supply system 1 for a mass spectrometer. The system comprises a positive voltage supply and negative voltage supply, and first and second optocouplers 19, 20 which are controlled by a controll

The invention provides an ion optical system high-voltage power supply for a mass spectrometer, and relates to the technical field of high-voltage power supplies, and the ion optical system high-voltage power supply for the mass spectrometer comprises a high-voltage input module of which the output end is connected with the first input end of a modulation circuit so as to provide a first input voltage for the modulation circuit; the input end of the low-voltage input module is in communication connection with the output end of the mass spectrometer, and the output end of the low-voltage input module is connected with the second input end of the modulation circuit so as to provide second input voltage for the modulation circuit; and the output end of the modulation circuit is connected with the input end of the mass spectrometer so as to modulate the second input voltage to obtain a target voltage. According to the ion optical system high-voltage power supply for the mass spectrometer, the low-voltage control signal is modulated into the target voltage through efficient communication with the control system of the mass spectrometer, and the diversified voltage requirements of the ion optical system of the mass spectrometer in different working modes are met.

The present invention relates to a method for analyzing and measuring sample materials deposited on the surface of a sample holder, comprising: (a) defining a plurality of regions on the surface, some of which are in contact with the sample material, (b1) using a desorption beam to sample a sample segment on one region to generate desorbed molecules, which are ionized and transferred to an analyzer, (b2) scanning the region along a non-linear trajectory selected from a plurality of predefined non-linear trajectories on the region by changing the orientation of the beam relative to the surface, while keeping the holder in one position, (c) using a spatial adjustment device of the sample holder to transition from the scanned region to the next region to be scanned, and (d) repeating steps (b1), (b2) and (c) until a predetermined termination condition is met. The present invention also relates to a system for analyzing ions, which has an ion generating device and a control unit.

The invention relates to the technical field of substance detection, and provides a substance detection method, a substance detection device and ion mobility spectrometry equipment. The method comprises the following steps: if it is determined that a to-be-detected sample enters an ionization region, controlling each corona ionization source to operate in sequence according to a corresponding initial operation mode based on preset operation setting, and obtaining initial mobility spectrometry data of each corona ionization source; determining a target operation mode corresponding to each corona ionization source based on the analysis of the multiple groups of initial migration spectrum data; based on preset operation setting, controlling each corona ionization source to operate in sequence according to the corresponding target operation mode to obtain target migration spectrum data of each corona ionization source; and identifying spectrum peak characteristics of the multiple groups of target migration spectrum data to obtain a component detection result of the to-be-detected sample. By adopting the design of the multi-path corona ionization source, the ionization efficiency and the resolution ratio of the ion mobility spectrometry are improved, and effective detection and distinguishing of different to-be-detected substances or difficult-to-distinguish substances are realized.

A quadrupole mass filter array consists of five quadrupole segments. An input quadrupole segment is configured to receive RF voltages. A secondary quadrupole segment is located downstream of the input quadrupole segment and is configured to receive RF and high-resolution DC voltages. A middle quadrupole segment is located downstream of the secondary quadrupole segment and is configured to receive RF voltages. A primary quadrupole segment is located downstream of the middle quadrupole segment and is configured to receive RF and high-resolution DC voltages. An end quadrupole segment is located downstream of the primary quadrupole segment and is configured to receive RF voltages.

A high-voltage (HV) power supply device outputs an output voltage based on a control signal generated by dual analog / digital feedback loops. The control signal is determined at least in part by an error amplifier that receives a measurement signal attenuated proportionally to the output voltage and an output signal from a digital-to-analog converter (DAC). The ADC also receives the measurement signal and transmits it in digitized form to a digital processor. The digital processor calculates a digital DAC data signal based on the measurement signal and a digital setpoint input signal corresponding to a setpoint voltage value desired to be output from the high-voltage source. The DAC receives the DAC data signal and converts it into a DAC output signal that is transmitted to the error amplifier.

Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus comprising first logic to generate an electrical signal in a first component of a scientific instrument, wherein the generated electrical signal induces, through capacitive coupling, an electrical response signal in a second component of the scientific instrument, second logic to monitor the electrical response signal induced in the second component, third logic to determine an operational status of the second component based on the monitored electrical response signal, wherein the operational status indicates that the second component is not functioning properly when the monitored electrical response signal is not within a predetermined signal range is disclosed.

A mass spectrometer includes an ion source configured to ionize a sample to produce ions; a mass analyzer configured to separate the ions based on their mass-to-charge ratio; a detector configured to detect ions; an ion optics component configured to direct ions along at least part of the path from the ion source to the mass analyzer to the detector; and a controller. The controller is configured to switch the source at a first time from a first polarity source voltage to a second polarity source voltage; and switch the detector or the ion optics component at a second time from a first voltage to a second voltage, the second time being offset from the first time, the first voltage being the first polarity detector voltage or the first polarity ion optics voltage and the second voltage being the second polarity detector voltage or the second polarity ion optics voltage.

The present invention relates to a self-tuning method and system for a quadrupole radio frequency power supply. The system comprises: a lower computer, a motor, and a resonant circuit, wherein the resonant circuit comprises a first adjustable inductor, a second adjustable inductor, a first fixed capacitor, and a second fixed capacitor, wherein the first fixed capacitor and the second fixed capacitor are connected in series to form a capacitor series branch, wherein the first adjustable inductor and the second adjustable inductor are respectively connected in series with the capacitor series branch, wherein the first adjustable inductor is connected to the first fixed capacitor in the capacitor series branch, and the second adjustable inductor is connected to the second fixed capacitor in the capacitor series branch, wherein the lower computer is connected to the motor, and the motor is connected to the first adjustable inductor and the second adjustable inductor. In view of the shortcomings of the original circuit adopting a manual tuning method to reach a resonant state, poor adjustment accuracy, and cumbersome operation, a recursive idea is adopted, and an automatic tuning algorithm is adopted to reach a resonant state, which has high efficiency, high accuracy, and simple operation; and the inductor is adjusted for tuning, thereby avoiding the use of high-precision adjustable capacitors and reducing costs.

A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor.

To reduce noise superimposed on an output voltage.SOLUTION: According to an embodiment of the present invention, a high-voltage power supply device comprises: a voltage generation unit that outputs a DC high-voltage; a switch unit that outputs an output voltage generated by the voltage generation unit to a voltage output end during conduction and uses a semiconductor switching element; a driving unit that drives a control terminal of a semiconductor switching element in the switch unit; and a control unit that controls conduction and non-conduction of the switch unit via the driving unit. The driving unit includes a primary winding (502a) and a secondary winding (502b). The driving unit includes: a high-frequency transformer (502) in which distribution, in an extension direction of the primary winding, of a floating capacity per number of unit turns of the primary winding between the primary winding and the secondary winding is symmetric to a midpoint of the primary winding; a rectification unit (505) that rectifiers an AC current energized by the secondary winding of the high-frequency transformer; and a high-frequency excitation unit (501) of balanced output type that differentially excites the primary winding of the high-frequency transformer.SELECTED DRAWING: Figure 2

The present invention improves the performance of a power module. In particular, the generation of discharge is prevented within the power module, and the power module is miniaturized. As a means for this, a plurality of substrates are arranged within the power module so as to overlap when viewed from above. In this case, a low-voltage circuit (3) and a high-voltage circuit are formed on a first substrate (2) while maintaining a distance (L) between each other for preventing creeping discharge, and a low-voltage circuit (5) is formed on a second substrate (4). In addition, the distance between the components constituting the high-voltage AC circuit (8) formed in the high-voltage circuit and the components constituting the low-voltage circuit (5) is at least three times the shortest distance (D) between the components constituting the high-voltage DC circuit (7) formed in the high-voltage circuit and the components constituting the low-voltage circuit (5) at which no space discharge occurs.

A system and method for detecting high-energy particles, the system comprising a detector unit and an AC coupler, the detector unit having a differentially biased detector having a first terminal for coupling to a positive bias voltage and a second terminal for coupling to a negative bias voltage, and the AC coupler having capacitively coupled input and output positive and negative terminals. The capacitive coupling is embedded in a transmission line structure, with the input positive terminal coupled to the first terminal of the detector and the input negative terminal coupled to the second terminal of the detector. Some advantages include reducing or eliminating resonance between the storage capacitor inductance and the detector capacitor, ringing due to common-mode excitation from the coaxial cable and the AC coupler circuitry, and undershoot and ringing due to reflections of low-frequency components blocked by the remotely mounted AC coupler.

An amplifier circuit 101 includes: a first current source circuit 113 configured to output a predetermined current amount to a first interconnect L1; a voltage amplifier circuit 110 configured to amplify a voltage of an input signal; a first level shift circuit 111 connected between the first interconnect L1 and an output of the voltage amplifier circuit 110 and configured to shift a voltage of a signal output from the voltage amplifier circuit 110; a first voltage follower 117 connected to the first interconnect L1 and configured to amplify a signal in the first interconnect L1; and a first capacitor 210 connected between the first interconnect L1 and the output of the voltage amplifier circuit 110.