131results about "Spectrometer circuit arrangements" patented technology

A power supply device applies a voltage to a quadrupole mass filter. The power supply device has a main substrate and a wave-detection substrate. The main substrate includes a detector. The wave-detection substrate includes a wave detector and an identifier. The wave detector detects an AC component of a voltage to be applied to the quadrupole mass filter as a wave-detection voltage. The identifier outputs identification information of the wave detector defined in correspondence with the configuration of a rectifying device of the wave detector. The detector detects identification information output by the identifier, and supplies the detected identification information to a corrector that corrects a deviation of voltage caused by a leakage current of the rectifying device.

Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.

The invention provides an ion detection amplifier and an ion detection method, and belongs to the field of mass spectrometers. The ion detection amplifier provided by the invention comprises a primary amplification circuit used for receiving a current signal output by an ion detector; the load module is connected with the primary amplification circuit in parallel, and the load module comprises a plurality of feedback branches; the secondary amplification circuit is connected with the output end of the primary amplification circuit, is used for amplifying an output signal of the primary amplification circuit, and is provided with a plurality of secondary gain gears; the gain switching control circuit is respectively connected with the load module and the secondary amplification circuit; and the signal processing circuit is used for receiving an output signal of the secondary amplification circuit. According to the ion detection amplifier and the ion detection method provided by the invention, collection, amplification, switching and digital output of ion signals can be accurately and efficiently completed in a complex scene.

An ion guide or ion trap that comprises a plurality of electrodes (102) is disclosed. The ion guide or ion trap includes a detector (205) that can detect light or particles (114) emitted from the ion guide or ion trap due to electrical breakdown, and a control circuit (111) that can control the ion guide or ion trap in response to the detector (205) detecting light or particles (114) emitted from the ion guide or ion trap.

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.

A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus includes, along a longitudinal direction, a first end cap electrode, a central electrode having an aperture, and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. Electric fields can be applied in a y-direction of the lateral plane across one or more planes perpendicular to the longitudinal axis to translocate and / or manipulate ion trajectories.

Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.

A radio frequency (RF) choke for use within a mass spectrometer comprises a bobbin having a hollow channel, a plurality of wire windings wound around the bobbin, each of the wire windings presenting a lattice winding pattern having a number of crossovers per turn of from about 1 to about 4, and a magnetic core disposed within the hollow channel of the bobbin. The RF choke exhibits an impedance in the range of from about 15 M ohms to about 150 M ohms with respect to an RF frequency generated by an RF voltage source within the range of from about 500 KHz to about 3 MHz, and a power dissipation equal to, or less than, about 3 W with respect to a peak-to-peak RF voltage of an RF voltage source of at least about 1 kV.

A power supply system 1 for a mass spectrometer. The system comprises a positive voltage supply and negative voltage supply, and first and second optocouplers 19, 20 which are controlled by a controll

The invention provides an ion optical system high-voltage power supply for a mass spectrometer, and relates to the technical field of high-voltage power supplies, and the ion optical system high-voltage power supply for the mass spectrometer comprises a high-voltage input module of which the output end is connected with the first input end of a modulation circuit so as to provide a first input voltage for the modulation circuit; the input end of the low-voltage input module is in communication connection with the output end of the mass spectrometer, and the output end of the low-voltage input module is connected with the second input end of the modulation circuit so as to provide second input voltage for the modulation circuit; and the output end of the modulation circuit is connected with the input end of the mass spectrometer so as to modulate the second input voltage to obtain a target voltage. According to the ion optical system high-voltage power supply for the mass spectrometer, the low-voltage control signal is modulated into the target voltage through efficient communication with the control system of the mass spectrometer, and the diversified voltage requirements of the ion optical system of the mass spectrometer in different working modes are met.

A quadrupole mass filter array consists of five quadrupole segments. An input quadrupole segment is configured to receive RF voltages. A secondary quadrupole segment is located downstream of the input quadrupole segment and is configured to receive RF and high-resolution DC voltages. A middle quadrupole segment is located downstream of the secondary quadrupole segment and is configured to receive RF voltages. A primary quadrupole segment is located downstream of the middle quadrupole segment and is configured to receive RF and high-resolution DC voltages. An end quadrupole segment is located downstream of the primary quadrupole segment and is configured to receive RF voltages.

A high-voltage (HV) power supply device outputs an output voltage based on a control signal generated by dual analog / digital feedback loops. The control signal is determined at least in part by an error amplifier that receives a measurement signal attenuated proportionally to the output voltage and an output signal from a digital-to-analog converter (DAC). The ADC also receives the measurement signal and transmits it in digitized form to a digital processor. The digital processor calculates a digital DAC data signal based on the measurement signal and a digital setpoint input signal corresponding to a setpoint voltage value desired to be output from the high-voltage source. The DAC receives the DAC data signal and converts it into a DAC output signal that is transmitted to the error amplifier.

Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus comprising first logic to generate an electrical signal in a first component of a scientific instrument, wherein the generated electrical signal induces, through capacitive coupling, an electrical response signal in a second component of the scientific instrument, second logic to monitor the electrical response signal induced in the second component, third logic to determine an operational status of the second component based on the monitored electrical response signal, wherein the operational status indicates that the second component is not functioning properly when the monitored electrical response signal is not within a predetermined signal range is disclosed.

A system and method for detecting high-energy particles, the system comprising a detector unit and an AC coupler, the detector unit having a differentially biased detector having a first terminal for coupling to a positive bias voltage and a second terminal for coupling to a negative bias voltage, and the AC coupler having capacitively coupled input and output positive and negative terminals. The capacitive coupling is embedded in a transmission line structure, with the input positive terminal coupled to the first terminal of the detector and the input negative terminal coupled to the second terminal of the detector. Some advantages include reducing or eliminating resonance between the storage capacitor inductance and the detector capacitor, ringing due to common-mode excitation from the coaxial cable and the AC coupler circuitry, and undershoot and ringing due to reflections of low-frequency components blocked by the remotely mounted AC coupler.

An amplifier circuit 101 includes: a first current source circuit 113 configured to output a predetermined current amount to a first interconnect L1; a voltage amplifier circuit 110 configured to amplify a voltage of an input signal; a first level shift circuit 111 connected between the first interconnect L1 and an output of the voltage amplifier circuit 110 and configured to shift a voltage of a signal output from the voltage amplifier circuit 110; a first voltage follower 117 connected to the first interconnect L1 and configured to amplify a signal in the first interconnect L1; and a first capacitor 210 connected between the first interconnect L1 and the output of the voltage amplifier circuit 110.

The performance of a power supply module is to be improved. The occurrence of discharge in the power supply module is to be prevented, and the size of the power supply module is to be reduced. In a power supply module, substrates are provided being stacked in a planar view. A low voltage circuit and a high voltage circuit are formed on a first substrate such that a distance is kept for preventing surface discharge, and a low voltage circuit is formed on a second substrate. A distance between a component of a high voltage alternating current circuit on the high voltage circuit and a component of the low voltage circuit is three times a shortest distance, at which space discharge does not occurs, between a component that constitutes a high voltage direct current circuit on the high voltage circuit and a component that constitutes the low voltage circuit.

In a TOFMS measurement unit, an ion acceleration section accelerates ions to send them into a flight space, within which a flight-field creation section creates, an electric field for causing ions to fly. A controller unit operates the measurement unit so as to repeat a measurement for a predetermined sample while varying a voltage applied to an electrode in the measurement unit, and calculates mass-resolving power based on each measurement result. An approximate function calculator unit finds an approximate function representing a relationship between the voltage and the mass-resolving power, based on data of combinations of the voltage and the mass-resolving power obtained under the control of the controller unit. A voltage determiner unit determines a voltage value corresponding to a target value of the mass-resolving power by the approximate function, and determines the voltage value as a voltage to be applied to the electrode in the TOFMS concerned.

To reduce variation of a measurement result by aligning a mass resolution of a plurality of devices.SOLUTION: In an embodiment of a TOFMS according to the present invention, the TOFMS includes a measurement part (1) containing: each flight magnetic field formation part that forms a magnetic field for flying an ion into a flight space (153, 154, and 155); and each ion acceleration part (151 and 152) that accelerates the ion as a measurement object and feeds it into the flight space. The TOFMS comprises: a control part (3) that repeatedly executes a measurement to a predetermined sample while changing a voltage applied to an electrode contained in the measurement part, and operates the measurement part so as to calculates a mass resolution on the basis of the measurement result in each measurement; an approximate calculation part (3) that calculates an approximate for approximating a relation of them on the basis of data of a plurality of pairs of an application voltage to the electrode and a resolution corresponded to them, obtained under a control by the control part; and a voltage determination part (3) that calculates a voltage value corresponded to a target value of the mass resolution by using the approximate, and determines the voltage value as an application voltage to the electrode in the device.SELECTED DRAWING: Figure 1

The gas analyzer (1) comprises a sample chamber (40) into which a sample gas (9) to be measured flows, a plasma generation circuit (10) that generates plasma (8) in the sample chamber (40), and an analyzer 30 that analyzes the sample gas via the plasma (8) generated in the sample chamber. The plasma generation circuit (10) includes a plasma induction circuit (13) and an RF power supply circuit (11) configured to supply RF power to the plasma induction circuit. The plasma induction circuit is directly incorporated as at least part of the resonant components of the RF power supply circuit.

A mass spectrometer system (10) is provided in which the voltage controller (12) can have separate first and second high-voltage control circuits (34, 40) which are physically disconnected from and at different ground planes to one another. Communication between the first and second high-voltage control circuits (34, 40) is enabled via an interface circuit (30) and one or more wireless, preferably radio- frequency, communicators (38, 44, 46, 48).

To provide an amplifier circuit that can be suppressed in heat generation and increases in size, and furthermore can materialize high frequency operation and high power.SOLUTION: An amplifier circuit 101 comprises a first current source circuit 113 that outputs a current having a predetermined amount of a current to a first wiring L1, a voltage amplifier circuit 110 that amplifies the voltage of an input signal, a first level shift circuit 111 that is connected between the first wiring L1 and the output of the voltage amplifier circuit 110 and shifts the voltage of the signal output from the voltage amplifier circuit 110, a first voltage follower 117 that is connected to the first wiring L1 and amplifies the signal in the first wiring L1, and a first capacitor 210 that is connected between the first wiring L1 and the output of the voltage amplifier circuit 110.SELECTED DRAWING: Figure 1

An ion detection current conversion circuit includes: a conversion amplifier coupled to a conversion resistor assembly to convert an ion detection current generated by an ion detector into an ion detection voltage, the conversion resistor assembly including a resistor with high resistance and a capacitor compensation element; and a compensation voltage circuit for obtaining a compensation voltage from the ion detection voltage and feeding the compensation voltage to the capacitor compensation element, the compensation voltage circuit including a variable resistor for adjusting the compensation voltage. The conversion circuit may further include: a voltage reduction circuit for obtaining a reduced voltage from the ion detection voltage; and a neutralization amplifier unit for at least partially neutralizing the voltage reduction of the voltage reduction circuit. The reduced voltage allows the use of low-voltage components, such as digital variable resistors.

The disclosure provides multimode configurable spectrometers, a method of operating a multimode configurable spectrometer, and an optical monitoring system. In one embodiment the multimode configurable spectrometer includes: (1) an optical sensor configured to receive an optical input and convert the optical input to electrical signals, wherein the optical sensor includes multiple active pixel regions for converting the optical input to the electrical signals, (2) conversion circuitry, having multiple selectable converting circuits, that is configured to receive and convert the electrical signals to a digital output according to a selected one of the selectable converting circuits, and (3) a sensor controller configured to set a synchronized operating mode to direct operation of the optical sensor and select, based on the synchronized operating mode, at least one of the selectable converting circuits to provide the digital output.

An example system includes a set of multipole electrodes and an RF generator configured to selectively output a signal voltage at a first frequency or at a second frequency for driving the set of multipole electrodes. The system also includes a low frequency transformer assembly and a high frequency transformer assembly. The system also includes a switching circuit configured to: connect the RF generator to a low frequency transformer assembly when the RF generator outputs an RF voltage at a first resonant frequency, the low frequency transformer assembly configured to supply the first voltage to an output coupled to the set of multipole electrodes based on the RF voltage; or connecting the RF generator to a high frequency transformer assembly when the RF generator outputs an RF voltage at a second resonant frequency, the high frequency transformer assembly configured to supply a second voltage to an output coupled to the set of multipole electrodes based on the RF voltage.

A method of mass spectrometry comprising: a) accumulating precursor ions in a first ion accumulator; b) performing a separation cycle including pulsing packets of precursor ions from the first ion accumulator to an ion separator and separating the precursor ions such that precursor ions having different values ​​of a first physicochemical property elute from the ion separator at different times; c) mass filtering the precursor ions eluting from the ion separator to transmit selected precursor ion species; and d) fragmenting or reacting the selected precursor ion species to produce a set of fragment or product ion species from the selected precursor ion species. e) accumulating the set of fragment or product ion species in a second ion accumulator; f) ejecting the set of fragment or product ion species from the second ion accumulator into a TOP mass analyzer, where operation of the TOP mass analyzer is synchronized with the ejection of ions from the second ion accumulator such that a plurality of different species of the set of fragment or product ion species are simultaneously pulsed by a pusher electrode into a time-of-flight region of the TOP mass analyzer; and g) repeating steps c)-f) at least once during a separation cycle, where the selected precursor ion species is different each time steps c)-f) are performed.

A mass spectrometer includes an orifice plate having an orifice, a first multipole ion guide in a first chamber downstream of the orifice plate, the first multipole ion guide including a plurality of rods, and a second multipole ion guide in a second chamber downstream of the first chamber, the second multipole ion guide including a plurality of rods. A first ion lens is between the first multipole ion guide and the second multipole ion guide. A third multipole ion guide is in a third chamber downstream of the second chamber, the third multipole ion guide including a plurality of rods. A second ion lens is between the second chamber and the third chamber. An adjustable DC voltage source applies an adjustable DC offset voltage to at least one of the above ion guides and ion lenses to increase the axial kinetic energy of the ions to cause at least one of de-clustering and / or fragmentation.

To improve ion measurement sensitivity in an apparatus that supplies precursor ions of an analysis target substance and active particles to a reaction chamber to cause a reaction therebetween, thereby generating and analyzing product ions.SOLUTION: An ion analysis apparatus (1) includes: a reaction chamber (132) into which precursor ions generated from an analysis target substance are introduced; an electrode (1331) provided inside the reaction chamber; an active particle generation unit (4) that generates active particles from a predetermined type of material gas; an active particle introduction unit (75) that introduces the active particles generated by the active particle generation unit into the reaction chamber while the precursor ions are introduced into the reaction chamber; and a voltage application unit (5) that applies, to the electrode, a voltage that forms an electric field accelerating product ions generated by a reaction between the precursor ions and the active particles toward an outlet of the reaction chamber while the precursor ions and the active particles are introduced into the reaction chamber.SELECTED DRAWING: Figure 1

An ion detection current conversion circuit (153) comprises: - a conversion amplifier (152) coupled with a conversion resistor assembly for converting an ion detection current produced by an ion detector into an ion detection voltage, the conversion resistor assembly comprising a resistor (151) having a high resistance and a capacitive compensation element (157), and - a compensation voltage circuit (158) for deriving a compensation voltage (Vcomp) from the ion detection voltage (Vout) and feeding the compensation voltage to the capacitive compensation element (157), the compensation voltage circuit comprising a variable resistor (201) for adjusting the compensation voltage. The conversion circuit may further comprise a voltage reduction circuit (R15, R16, 220) for deriving a reduced voltage (Vred) from the ion detection voltage (Vout) and a neutralizing amplifier unit (211) for at least partially neutralizing the voltage reduction of the voltage reduction circuit. The reduced voltage allows low-voltage components, such as digital variable resistors, to be used.

This invention discloses a segmented quadrupole system incorporating phase control, comprising a segmented quadrupole structure, a direct digital synthesizer, a first phase shifting device, a second phase shifting device, a first radio frequency high voltage output device, and a second radio frequency high voltage output device. Compared to traditional quadrupole systems that increase radio frequency high voltage and frequency, this invention achieves high resolution while reducing electrical noise and power loss in the radio frequency system and improving power supply control accuracy, as it eliminates the need to increase high voltage and frequency. This results in higher instrument reliability while maintaining high resolution. By dividing the long quadrupole into multiple short segments—at least one first quadrupole and at least one second quadrupole—the manufacturing precision requirements for single-segment quadrupole electrodes are effectively reduced, simplifying the manufacturing process, improving overall mechanical stability, and minimizing the impact of thermal deformation and mechanical vibration on mass spectrometer performance.

Methods for operating a mass spectrometer, particularly an inductively coupled plasma mass spectrometer (ICP-MS), having a skimmer 30 and a circuit 40 for applying an electric potential to the skimmer