412results about "Spectrometer circuit arrangements" patented technology

The present invention relates to a mass spectrometer, and more specifically a portable mass spectrometer. In one implementation, the mass spectrometer includes a toroidal transformer. In another implementation, the mass spectrometer includes feedback circuitry to monitor signals applied in the mass spectrometer.

A digital drive apparatus (FIG. 3) for quadrupole device such as a quadrupole ion trap has a digital signal generator (11, 13, 14; 24, 25, 26) and a switching arrangement (16, 17) which alternately switches between high and low voltage levels (V₁, V₂) to generate a rectangular wave drive voltage. A dipole excitation voltage is also supplied to the quadrupole device to excite resonant oscillatory motion of ions.

A circuit is described for applying RF and AC voltages to the elements or electrodes of an ion trap or ion guide. The circuit includes an RF transformer having a primary winding and a secondary winding. The secondary winding includes at least two filars. A broadband transformer adapted to be connected to a source of AC voltage applies AC voltage across the low-voltage end of two of the filars. Another broadband transformer connected to the filars at the high-voltage end provides a combined RF and AC output for application to selected electrodes. Also described is a circuit employing a multi-filar RF transformer and broadband transformers for applying RF and AC voltages to spaced rods of a linear ion trap. Also described is a circuit employing a multi-filar RF transformer and broadband transformers for applying RF and AC voltages to the electrodes in each section of a linear ion trap of the type having a center section and end sections, and different DC voltages to the electrodes in the end sections.

The output terminal P2 of the positive voltage generating circuit 2 and the output terminal Q1 of the negative voltage generating circuit 4 are connected in series. The output terminal Q2 of the negative voltage generating circuit 4 is connected to the ground via the resistor 10. Each of the resistors 6 and 7 is respectively connected in parallel to the voltage generating circuits 2 and 4. A high voltage whose polarity is changed is taken from the output terminal P1 of the positive voltage generating circuit 2. For changing the output voltage from positive to negative one, the control circuit 1 controls each of the drive circuits 3 and 5 so that the output of the positive voltage generating circuit 2 changes from the voltage +HV to zero and the output of the negative voltage generating circuit 4 simultaneously changes from zero to −HV. Accordingly, the output voltage changes in a short period of time. Although a high-voltage-resistance resistor is required in this configuration, it is far more inexpensive and has higher reliability compared to a high-voltage relay or a semiconductor switch which has been conventionally used.

An apparatus for electronically controlling a quadrupole in a mass spectrometer, comprises radio frequency (RF) drive circuitry and direct current (DC) drive circuitry coupled to a quadrupole, an RF control loop associated with the RF drive circuitry, a DC control loop associated with the DC drive circuitry, and control loop circuitry associated with the DC control loop, the control loop circuitry configured to alter a response of the DC control loop during a settling time period of a step response such that ion transmission through the quadrupole is greater during the settling time than if the response of the DC control loop during the settling time is unaltered.

The apparatus introduces a second adjustable resonant point in a QMS at a frequency that is close to a multiple of the fundamental frequency by adjusting driving point impedance characteristics of the QMS. The apparatus measures the first and second resonant point of the QMS to account for changes in the operational characteristics of the QMS.

System and method for operating an ionizer using a combination of amplitude modulation and pulse width modulation to control the plasma temperature and the type of ions needed for analytic equipment. Ion density can be controlled by the repetition rate. The ionizer may utilize a non-radioactive ionization source, and be coupled to a differential mobility spectroscopy (DMS) analyzer.

A table (21) for relating an appropriate DC bias voltage to each of a plurality of selectable scan speeds is stored beforehand in an auto-tuning data memory section (20). In an auto-tuning operation, a controller (10) determines the DC bias voltage corresponding to each scan speed by referring to the table (21) and fixes the output of an ion-drawing voltage generator (13) at that voltage. Subsequently, while changing the voltages applied to relevant sections such as an ion optical system (2), the controller (10) finds voltage conditions under which the detection signal is maximized. The conditions thus found are stored in an auto-tuning result data (22). In an analysis of a target sample, a DC bias voltage corresponding to a scan speed specified by an operator is obtained from the DC bias voltage table (21), and the optimal conditions for this voltage are obtained from the auto-tuning result data (22). Based on these items of information, conditions for the scan measurement are determined. This method prevents the deterioration in detection sensitivity, which will otherwise take place if the scan measurement is performed at a high scan speed.

An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.

In the ion storage device 10 according to the present invention, an LC resonant circuit 40 for generating an RF voltage for trapping ions is connected to at least one of the electrodes 11, 12 and 13 surrounding the ion storing space 14. The LC resonant circuit 40 includes switching devices 46, 47 and resistances 48, 49 for stopping the RF voltage when the ions stored in the ion storing space 14 are ejected. The inductance L, the capacitance C and the resistance R of the LC resonant circuit are set to substantially satisfy the critical damping condition, which means that R=X/2 where X=ω₀L=(ω₀C)⁻¹. According to this configuration, the RF voltage damps fast when the RF voltage is stopped by the switching devices 46, 47, and the deterioration of the mass resolution of the mass analyzer or the peak shift in the mass spectrum is prevented.

A signal denoising method for a frequency-scan ion trap mass spectrometer includes reading a signal raw data array observed in the spectrometer. The signal raw data array is processed by Boxcar averaging method to obtain a first signal array. Then the first signal array is processed by a harmonic interference cancellation method to obtain a second data array. Next the second signal array is processed by a radio frequency interference reduction method and a third signal array without the background induced from driving voltage of ion trap is reconstructed according to the second signal array.

A method of detecting constituents in a sample includes generating a plurality of ions in an ionization region. The method also includes preventing the plurality of ions in the ionization region from flowing into a drift region through inducing a first voltage in a device positioned between the two regions. The method further includes injecting at least a portion of the ions from the ionization region into the drift region. The method also includes regulating the voltage in the device to a second voltage for a first predetermined temporal period, the second voltage less than the first voltage. The method further includes regulating the voltage in the device to the first voltage. The method also includes regulating the voltage in the device to the second voltage for a second predetermined temporal period, the second predetermined temporal period different from the first predetermined temporal period.

The present invention discloses an mixed signal RF drive electronics board that offers small, low power, reliable, and customizable method for driving and generating mass spectra from a mass spectrometer, and for control of other functions such as electron ionizer, ion focusing, single-ion detection, multi-channel data accumulation and, if desired, front-end interfaces such as pumps, valves, heaters, and columns.

The present invention provides methods and electronic circuits for a chemical analyzer, for example, a mass spectrometer, which provide generated signals that are maintained to a required level of precision. A user may specify the required precision for the signals which operate the spectrometer and may specify the required precision for the mass analysis, either explicitly or by choosing a predefined configuration. The spectrometer will then generate the signals to the required precision despite changes in operating conditions, environmental conditions, component aging and degradation, or other nonfailure effects that otherwise affect analyzer calibration and signal output. The electronic circuits incorporate signal monitoring to maintain closed-loop signal control. The closed-loop control includes a feedback path which may include discrete components and may include software enabling a processor to adjust the generated signals to maintain the required precision of the signals and analysis. Further, the spectrometer may monitor signals and analyze and store data in order to predict future performance, including precision, analysis limitations, impending component degradation or failure, or another parameter associated with a component or signal of the spectrometer. Specifically, a range for a particular parameter may be specified and a indication provided to a user when the parameter exceeds the specified range.

A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter, a collision cell, an ion mobility spectrometer or separator, an ion guide or collision cell arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter and an ion detector.

Disclosed herein is a mass spectrometry method having steps of: transmitting ions from an ion source through a mass filter; processing ions received from the mass filter in a discontinuous ion optical device downstream of the mass filter; operating the mass filter for a plurality of periods in a mass/charge ratio (m/z) filtering mode to transmit ions in one or more selected ranges of m/z to the discontinuous ion optical device; and operating the mass filter in a broad mass range mode transmitting ions of a mass range substantially wider than any mass range transmitted in the m/z filtering mode during one or more periods in which the discontinuous ion optical device is not processing ions from the mass filter. Utilization of this method assists to reduce contamination in the mass filter.