190 results about "Electrospray" patented technology

The invention relates to the technical field of soil conditioners, and particularly discloses an intelligent controlled-release core-shell alginate soil conditioner and a preparation method thereof.The conditioner is of a core-shell-layer three-layer structure and comprises a core layer, a middle shell layer and an outer layer, the three layers account for 30%, 40% and 30% of the total weight respectively, and the core layer mainly comprises improved alginate and nutrients; the middle shell layer mainly comprises chitosan and a microbial preparation; and the outer layer mainly comprises modified charcoal and magnetic nano # imgabs0 #. The preparation method comprises the four steps of core layer preparation, middle shell layer coating, outer layer coating and forming post-treatment, and multiple functions of accurate nutrient supply, efficient heavy metal fixation and soil microenvironment regulation and control are achieved through a core-shell-layer three-layer structure design and a pH / temperature / microorganism triple response mechanism by adopting a coaxial electronic injection and layer-by-layer self-assembly technology; the fertilizer has a remarkable improvement effect on sandy soil and saline-alkali soil, and the organic matter increasing rate reaches 40%.

A plant holder for holding an amount of rooting (growing) media in which plant roots develop that electrically isolates the plant roots from an electric field used to deliver water and plant nutrients to that rooting media via a high-voltage, low-current electrospray system. A conductive material disposed proximate the rooting media receives electrically charged droplets including water or nutrients and passes the water or nutrients to the rooting media while directing the electrical charge to ground.

The invention discloses a single-cell metabolite spectrum quantitative analysis platform and method based on droplet microfluidics, and relates to the technical field of mass spectrometry. The platform comprises a fluid pumping module, a cell oscillation module, a microfluidic mixed liquid drop generation module, a microfluidic mixed liquid drop reinjection and separation module and a mass spectrometry module. The fluid pumping module comprises a high-pressure nitrogen cylinder and a gas pressure driver; the cell oscillation module comprises a cell oscillator; the micro-fluidic mixed droplet generation module comprises a micro-fluidic droplet generation chip, a cell lysis solution, an internal standard, an oil phase, a cell suspension and a droplet collection and incubation centrifugal tube; the micro-fluidic mixed liquid drop reinjection and separation module comprises a micro-fluidic liquid drop reinjection and separation chip; and the mass spectrometry module comprises an electrospray needle and a mass spectrometer. According to the method, the single cell is captured and the internal standard substance is introduced at the same time by using droplet microfluidics, and mass spectrometry is carried out, so that high-flux single cell encapsulation and accurate quantification of metabolites are realized.

The invention relates to the technical field of plasma concentration monitoring methods, in particular to a method for rapidly detecting the content of tacrolimus in plasma through paper spray mass spectrometry. The method provided by the invention comprises the following steps: adding a to-be-detected plasma sample into a precipitation solution, vortex, taking supernate, and dropwise adding the supernate onto a paper base; spraying voltage is applied to the paper base, the paper base generates electrospray, and the electrospray enters a mass spectrometer for detection; preparing a gradient matrix matched tacrolimus standard solution, replacing the to-be-detected plasma sample with the gradient matrix matched tacrolimus standard solution, repeating the operation, recording a detection result, and drawing a standard curve by taking the matrix matched tacrolimus concentration as an abscissa and taking peak area data acquired by a mass spectrometer as an ordinate; and comparing the recorded detection result with the drawn standard curve, and quantitatively analyzing the content of tacrolimus in the to-be-detected plasma sample. The method disclosed by the invention is simple to operate and high in analysis speed, has relatively good precision and accuracy and also has high sensitivity and high selectivity.

The invention provides an array type composite emitter ionic liquid electrospray thruster containing a far-end electrode, and relates to the technical field of spaceflight thrusters, an insulating material is adopted to process a composite emitter assembly, so that a double charge layer is generated at an ionic liquid electrode component, electrochemical reaction cannot be generated at an inner flow channel of a composite emitter, and the composite emitter assembly is made to be uniform. The problem that an electrochemical reaction product is directly generated in the composite emitter to block an internal flow channel of the emitter is avoided, and through the arrangement of a transverse flow channel, a vertical flow channel and a liquid collecting tank, a zigzag liquid flow channel is formed, so that the electrochemical reaction product generated at the electrode component is more uniform and uniform. When the ionic liquid flows, the ionic liquid is limited at the position of the electrode component by the flow channel wall surface and cannot enter the inlet of the base flow channel of the composite emitter assembly along with the ionic liquid, so that the influence of electrochemical reaction on the work of the composite emitter is prevented.

The invention belongs to the technical field of detection methods, and particularly relates to a liquid chromatography detection method for an idedecalciferol intermediate and impurities thereof. According to the liquid chromatography detection method for the eldecalciferol intermediate and the impurities thereof, a liquid chromatography method is combined with an electrospray detector for detection; chromatographic conditions are as follows: an amylose-tri (3-chlorphenyl carbamate) covalently bonded silica gel chromatographic column is adopted; and carrying out gradient elution by taking water as a mobile phase A and acetonitrile as a mobile phase B. The method for detecting the eldecalciferol intermediate and the impurities of the eldecalciferol intermediate is good in specificity, high in sensitivity and accuracy, good in repeatability and stability and high in analysis speed, the content of the eldecalciferol intermediate and the impurities of the eldecalciferol intermediate can be rapidly and accurately detected, and the blank of detection of the eldecalciferol intermediate and the impurities of the eldecalciferol intermediate in the prior art is filled.

The invention discloses a method for detecting multiple perfluorinated compounds in a water environment. The method comprises the steps of sample collection and preservation, sample pretreatment and LC-MS / MS detection. According to the invention, trace detection is carried out on common perfluorinated compounds in a water environment by adopting solid-phase extraction-liquid chromatography-electrospray-tandem triple quadrupole mass spectrometer, a more perfect and comprehensive LC-MS / MS detection method for multi-medium concentration of perfluorinated compounds is provided, and on the premise that the recovery rate and the accuracy of a detection result are ensured, the detection efficiency is improved. The sample pretreatment modes in different media are optimized and adjusted, so that the experiment process is more convenient and faster, time and labor are saved, the use of traditional glass material consumables is avoided, and the experiment error is reduced; meanwhile, the method disclosed by the invention is wider in application range, can meet trace detection of perfluorinated compounds in surface water, underground water, domestic sewage, industrial wastewater, river sediment and residual sludge of a sewage plant, and provides data support for quality supervision and risk early warning in a water environment.

The invention relates to the technical field of food safety detection, in particular to a method for detecting urea in bean sprouts and application thereof.The method comprises the following steps that smashed bean sprouts are subjected to two times of ultrasonic extraction and centrifugation, supernate is combined, and an extracting solution is obtained; fixing the volume and filtering to obtain a to-be-detected solution; detecting the liquid to be detected by using liquid chromatography-tandem mass spectrometry; an extraction solvent for ultrasonic extraction is a 5% formic acid-acetonitrile composite solution; the conditions of the liquid chromatography-tandem mass spectrometry are as follows: the chromatographic conditions are as follows: a chromatographic column is an HILIC column; the sample size is 10 [mu] L; a mobile phase is a mixed solution of a 0.02 mmol / L ammonium acetate buffer salt solution and acetonitrile, and isocratic elution is carried out; the flow rate is 0.3 mL / min; the column temperature is 40 DEG C; mass spectrum conditions are as follows: an electrospray ionization (ESI) positive ion mode, electrospray voltage of 4000 V, sheath gas pressure of 30 psi, auxiliary gas pressure of 5 psi, capillary heating temperature of 300 DEG C and scanning mode of MRM. The method disclosed by the invention is free from substance interference, high in sensitivity, accurate in result, low in cost and high in efficiency, and can be used as a standard detection method.

The present application relates to the technical field of microsphere preparation, and particularly relates to a microsphere-based electrospray device, which comprises a nozzle, a conductive piece and a power supply, the nozzle has a solution channel, the solution channel has an inlet and an outlet, the conductive piece is arranged at a position adjacent to the outlet, the power supply comprises a first output end and a second output end, the first output end is connected with the outlet to provide a first electric field, the second output end is connected with the conductive piece to provide a second electric field, and the direction of the first electric field is arranged orthogonally to the direction of the second electric field, the microsphere-based electrospray device can improve the uniformity of the prepared microspheres.

The invention discloses an analysis method for determining multiple components of white spirit by high performance liquid chromatography-tandem mass spectrometry, and relates to the technical field of white spirit analysis and detection, and the analysis method comprises the following steps: firstly, preparing an ethyl carbamate precursor substance standard stock solution and a mixed standard intermediate solution, and diluting the mixed standard intermediate solution step by step to obtain a mixed standard working solution; then determining chromatographic and mass spectrometry conditions, wherein BEH Ami chromatographic column is adopted as the chromatographic condition, and 0.1% formic acid water-acetonitrile is adopted as a mobile phase for gradient elution; a mass spectrum condition adopts a multi-reaction monitoring mode under an electrospray positive ion mode; drawing a quantitative calibration curve; finally, preparing a to-be-detected sample for content determination. According to the analysis method for determining the multiple components of the Baijiu through the high performance liquid chromatography-tandem mass spectrometry, through chromatographic condition optimization and mass spectrometry parameter innovation, the detection efficiency is improved, peak area data of urea, citrulline and arginine can be synchronously obtained through single sample injection, the analysis time is short, and quantification is accurate.

Disclosed herein are electrospray emitter devices for delivering a fluid sample to a mass spectrometer, the emitter devices comprising a sample capillary extending from a sample inlet to a sample outlet said sample capillary defining a path for fluid flow from the sample inlet to the sample outlet. The sample Inlet is configured to receive a fluid sample, the fluid sample being an eluent from a liquid chromatograph. A reagent capillary extending from a reagent inlet to a reagent outlet, the reagent capillary defining a path for fluid flow from the reagent inlet to the reagent outlet. A first conduit disposed around a first portion of the sample capillary and a first portion of the reagent capillary; the first conduit comprises a wall defining a lumen, the first conduit extends from a first end to a second end opposite and axially spaced apart from the first end.

The utility model relates to the technical field of ion source spray needles, in particular to a convenient and fast disassembly type ion source spray needle which comprises an ion source support, an electrospray ion source fixedly installed at the bottom, a fast installer fixedly installed on the outer side of the bottom and an installation connector fixedly installed at the bottom. The spray needle assembly is mounted at the bottom of an electrospray ion source through a quick mounting device. When the spray needle body needs to be dismantled, the hand-operated grab bar can be pushed by manually pulling the hand-operated grab ball to drive the quick-release linkage frame body to move downwards, the displacement block slides in the guide rail for guiding to enable the quick-release linkage frame body to move downwards stably, and the bottom inclined face of the quick-release linkage frame body makes contact with the inner end arc face of the guide frame body for guiding; the guide frame body is opened to enable the two sides of the guide frame body to slide, the sliding block is pushed to extrude the limiting spring, the clamping block at the end of the limiting frame is separated from the clamping groove, the spray needle connector loses limitation, and the spray needle assembly is rapidly disassembled.

The invention belongs to the field of liquid chromatography-mass spectrometry detection, and discloses a liquid chromatography-mass spectrometry detection method for trace target objects in seawater, which comprises the following steps: firstly, configuring and precisely calibrating parameters such as flow velocity, column temperature, ion source voltage and the like for a liquid chromatography system, a chromatographic column, an automatic sampler and a tandem mass spectrometer; then, a methanol-water (containing 0.1% formic acid) system is adopted to implement linear gradient elution, polar difference component separation is considered, and analysis duration is compressed; a sample is subjected to solid-phase extraction, purification and concentration, then is automatically injected, is subjected to chromatographic separation and then enters an electrospray ion source; a mass spectrum end selects a dynamic multi-reaction monitoring (dMRM) mode, characteristic ion pairs are collected in a preset time window, and selective scanning and baseline noise suppression are achieved; and finally, utilizing retention time matching and internal standard correction to obtain a pg.L <-1 > magnitude quantitative result.

The application provides a kind of ionic liquid electric spray micro force calculation method, device and electronic equipment, it is related to data processing field, the method is carried out original molecular dynamics simulation in the negative gradient calculation of position to atomic potential energy and obtains the force model, the micro force decoupling of ionic liquid electric spray under molecular dynamics simulation is executed;Based on the micro force model, the molecular dynamics trajectory data is recalculated by modifying the molecular dynamics simulation code parameters, the pre-data of different micro forces is obtained, and the atomic force calculation result is output based on the pre-data of different micro forces;The atomic force calculation result corresponding to the steady state part of system is calculated by time and space average, and the spatial distribution calculation result of micro force and electric field is obtained;After a spatially uniform distribution of constant electric field is applied to the system, the first external electric field received by the charged atom is calculated using the above scheme, and the applied electric field and the calculated electric field are consistent, which verifies that the scheme is executed without error.

The application discloses a capillary type ion liquid electric spray thruster with electrically controlled thrust, and belongs to the technical field of micro-nano satellite micro propulsion. The application comprises a propellant tank, an upper shell, a constant force spring, a limiting plate, a capillary and an extraction electrode. The inner and outer walls of the capillary are covered with a dielectric layer with a micron level thickness, and the inner wall is covered with a hydrophobic layer with a nanometer level thickness. The extraction electrode is fixed through an insulating screw; and the upper shell is fixed with the propellant tank. The application is based on the principle of electric wetting, uses an electric field to control the active supply of ion liquid and simultaneously adjusts the thrust size of the thruster. The application can not only save complicated fluid control components such as high-precision pumps, valves and pipelines, but also can couple the supply process and the emission process of the ion liquid, simplify the operation process of the thruster system and facilitate the miniaturization of the thruster system. The application is suitable for resistance compensation, position keeping and attitude control of low-power micro-nano satellites.

A portable, hand-held electrospinning or electrospraying apparatus and system, method, and portions thereof, comprised of a durable portion of the hand-held apparatus and a consumable portion of the hand-held apparatus. The consumable portion of the hand-held apparatus, which may contain the solution to be output in electrospin or electrospray fashion, may be replaced in whole or in part to provide additional or alternative solution. A base station may be provided, and can output high voltage and communication signals to the hand-held apparatus to enable the electrospin or electrospray operation by the hand-held apparatus.

The invention discloses a precise adjustable electrospray thruster device which is characterized in that an emitter mounting bracket is used for fixing a porous ceramic emitter, and the fixed porous ceramic emitter can move along with the mounting bracket; the special-shaped groove in the mounting bracket is used for quickly positioning the mounting bracket; the fine adjustment of the relative position between the porous ceramic emitting electrode and the extraction electrode can be realized by adjusting a spring jackscrew in a horizontal plane and a fastening screw in a vertical plane; the fine adjustment process can be operated under a microscope to improve the adjustment precision; the shell of the electrospray thruster is designed to be of a spiral twenty-four-face structure and is machined and formed through the 3D printing technology, and the weight of shell parts is further reduced by designing a hollow cavity in the shell.

An electrospray apparatus comprising a capillary emitter.

The application provides a detection method of hydroxypropyl cellulose in a povidone-containing preparation, and specifically comprises the following steps: (1) preparing a sample solution by pretreating a sample to be detected; (2) detecting the sample solution by using HPLC, wherein an evaporative light scattering detector or an electrospray detector is used as a detector, a C18 chromatographic column is used as a chromatographic column, the column temperature is 20-40 DEG C, water is used as a mobile phase A, methanol is used as a mobile phase B, the flow rate is 0.5 ml / min-1.5 ml / min, and gradient elution is adopted. The detection method has good specificity and peak type, can not only separate hydroxypropyl cellulose from povidone and other high-molecular auxiliary materials in a pharmaceutical preparation, accurately quantify the content of hydroxypropyl cellulose, but also effectively identify the model, and provides a good method for reverse analysis, component analysis, auxiliary material release detection of the pharmaceutical preparation.

The invention discloses a plasma electrospray fusion ionization source and mass spectrum combined system and a detection method. The plasma electrospray fusion ionization source and mass spectrum combined system comprises a coaxially nested electrospray needle, a sample injector, an ultrahigh voltage generator, a grounded metal grid mesh, a mass spectrometer and a detector thereof. A grounded metal grid is installed between a spray needle and a mass spectrum inlet, voltage is applied to the spray needle, carrier gas is excited to generate plasmas, the macroscopic plasmas at the front end of the spray needle are fused with electrospray, and the plasmas and micro-droplets at the tip of the spray needle are fused. According to the unique ionization source constructed by the plasma-micro-droplet fusion system, on one hand, the ionization efficiency is improved, mass spectrum signals are enhanced, the application range of analytes is widened, excellent sensitivity to high-polarity compounds is kept, and effective ionization and detection of low-polarity compounds are achieved; on the other hand, higher energy and active species are provided for the micro-droplet reaction, the energy barrier required by traditional synthesis is broken, and efficient spontaneous product generation of the micro-droplet chemical reaction is achieved.

The present application belongs to the technical field of curved surface electronic Wiener manufacturing, and discloses an insulating surface electroblotting device and method based on real-time plasma processing, which comprises an electroblotting assembly and a plasma assembly, wherein the electroblotting assembly and the plasma assembly work synchronously; the electroblotting assembly is used for conveying ink to a nozzle to form a jetting jet; the plasma assembly is used for processing an insulating surface by adopting a ring-shaped plasma beam to inject a polarized group into the insulating surface, and the polarized group generates a negative polarity charge under the action of an electroblotting electric field, and at the same time, residual charges of ink liquid and polarized charges of the insulating surface are neutralized to realize stable jetting and deposition of ink jets / drops on the insulating surface. The present application solves the printing and forming problem of a complex microstructure of an insulating substrate.

The invention relates to the technical field of tobacco chemical analysis, in particular to a multistage mass spectrometry identification method for chemical structures of sucrose esters in tobacco and tobacco products, which comprises the following steps: crushing and extracting a tobacco product sample; carrying out solid-liquid separation and filtration to obtain a liquid to be detected; separating the liquid to be detected by adopting hydrophilic interaction chromatography; performing triple quadrupole-ion trap tandem mass spectrometry analysis on the components separated in the step S2 by adopting an electrospray ion source in a positive ion mode to sequentially obtain mass spectrometry information of parent ions, daughter ions and grandchild ions; and determining the chemical structure of the sucrose ester based on the mass spectrum information of the parent ion, the daughter ion and the grandchild ion measured in the step S3. According to the method, complex pretreatment steps are not needed, sucrose esters with different configurations can be identified more efficiently, interference can be effectively eliminated, and substituent group structure information of a low-content target object can be scientifically confirmed.

The invention relates to a qualitative and quantitative method for detecting active ingredients of root-strengthening and cough-relieving granules through UPLC-MS / MS, and belongs to the technical field of medicine analysis and detection. The four active ingredients of liquiritigenin, isoliquiritigenin, luteolin and bakuchiol in a sample can be detected at the same time. The method comprises the following steps: pretreating a sample by a 70% methanol ultrasonic extraction method to obtain a target sample solution, and detecting by using an SCIEX ExionLC AE high-pressure liquid phase system and an AB SCIEX 4500 mass spectrometer in combination with an MRM mode. Carrying out gradient elution on a liquid phase by using an HSS T3 C18 chromatographic column and 0.1% formic acid water-acetonitrile as a mobile phase; the mass spectrum is electrospray negative ion scanning, and a specific ion source and MRM parameters are set. The method can rapidly separate the four components, is short in detection period, high in sensitivity and strong in matrix interference resistance, can be accurately qualitative and quantitative, and provides support for preparation quality evaluation, pharmacodynamic mechanism research and clinical reasonable medication.

Disclosed is an electrospray probe for an electrospray ion source, the electrospray probe comprising a sleeve extending from a proximal end having an inlet aperture for receiving a liquid sample containing at least one analyte to a discharge emitter end having an outlet aperture through which charged droplets containing ions of the analyte are discharged, and a conductive coating covering at least a portion of an outer surface and at least a portion of an inner surface of the emitter end.

The invention provides a pipeline structure for an electrospray expiration source, comprising: a gas path structural member provided with a first end and a second end opposite to each other; a first sheath gas channel and an auxiliary gas channel are formed in the gas path structural member; at the first end, the first sheath gas channel is connected with the sheath gas outlet; the auxiliary gas channel is connected with the auxiliary gas outlet; at the second end, the first sheath gas channel is connected with the first end of the sheath gas tube through a metal connecting piece; the auxiliary gas channel is connected with the first end of the auxiliary gas pipe through a metal connecting piece. The metal connecting piece is used, the sheath air pipe and the auxiliary air pipe are installed on the air path structural piece, the pipeline installation stability can be effectively improved, the situation that the sealing effect of the pipeline is affected by high temperature is avoided, the service life of the auxiliary air pipe and the sheath air pipe is prolonged, and for a high-voltage line connecting structure of an expiration source, limitation of a traditional glue pouring curing technology is broken through; therefore, the problem that the whole module is scrapped due to the fact that the cable cannot be replaced when a fault occurs is avoided.

The invention relates to a novel analysis method for carrying out lipid gas phase dissociation by adopting pulse extreme ultraviolet laser and characterizing a lipid molecular structure by analyzing dissociated fragment ions through mass spectrometry. A lipid sample enters a gas phase through electrospray ionization, then lipid molecules with accurately selected mass are efficiently excited and dissociated by adopting extreme ultraviolet laser to generate fragment ions with sequence and structural characteristics, and finally the fragment ions are detected through mass spectrum. According to the method, efficient extreme ultraviolet light dissociation of lipid molecules can be achieved, structural characteristics such as head groups, sn positions, double bond positions and cis-trans isomerism of the lipid molecules can be accurately determined through fragment ion spectrogram analysis, and accurate identification and distinguishing of complex lipid isomers are achieved.

The invention belongs to the technical field of vitamin content detection, and particularly relates to a method for measuring the content of various water-soluble vitamins B. The water-soluble vitamins B comprise vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B7, vitamin B12 and nicotinamide. A high performance liquid chromatograph and an electrospray detector are used as detection instruments, and chromatographic conditions are as follows: a mobile phase A is ammonium formate or ammonium acetate, a mobile phase B is methanol, and gradient elution is performed; the gradient elution procedure is as follows: a solvent of a test sample is a mixed solution of acetonitrile, water and glacial acetic acid, and the volume ratio of the acetonitrile to the water to the glacial acetic acid is 5: 95: 0.5; the atomization temperature of the electrospray detector is 35 DEG C; the method is better in separation degree and higher in specificity and sensitivity.

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

The application belongs to the field of advanced manufacturing technology, and proposes a micro-nano electro-fluid jet printing method based on electric field focusing and deflection control. The method uses double circular rings as induction electrodes to induce the printing of charged droplets with micro-nano scale resolution at the metal micro-tip of the ink, and then uses the time-varying pulse voltage signal generated by the jet deflection electrode to control the flight trajectory of the droplets, so as to print high-precision micron patterns on the stationary receiving plate. Combined with the movement of the work platform, macro-scale structures can be further manufactured. The method breaks through the limitation that the trajectory movement of the work platform is necessary for the electro-fluid jet printing of micron patterned structures, and can realize the deposition of any pattern on a stationary platform, and has the characteristics of high printing resolution, high precision and high efficiency.