1289 results about "Chromatography column" patented technology

The invention discloses an on-load tap-changer oil dissolved gas monitoring device which comprises a variable capacity container, a two-way electromagnetic valve, a switching mechanism, a chromatographic column system, a high-sensitivity detector and a low-sensitivity detector which are sequentially connected, and the top and the bottom of the variable capacity container are connected through a circulating pump to form a gas flow loop. The variable-capacity container is connected with the on-load tap-changer through a connecting pipe, the switching mechanism is connected with at least two quantitative pipes with different capacities, and the switching mechanism is used for equally transferring gas in the variable-capacity container to the quantitative pipes and then sequentially transferring the gas in the quantitative pipes to the chromatographic column system. The invention further discloses a method for monitoring the dissolved gas in the on-load tap-changer oil. According to the monitoring device and the monitoring method for the dissolved gas in the oil of the on-load tap-changer, the detection range of the concentration is improved, a concentration blind area which is not detected and misjudgment of signal saturation can be avoided, and the detection accuracy is improved.

The invention discloses a liquid chromatography-mass spectrometry data peak shape recognition processing method and related equipment, and relates to the field of data processing. The method comprises the following steps: acquiring liquid chromatography-mass spectrometry data; extracting morphological characteristic data of a chromatographic peak based on the extracted ion current chromatogram time sequence; calculating and extracting a signal complexity index of the ion current chromatogram time sequence; adjusting peak shape identification parameters according to the signal complexity index, wherein the peak shape identification parameters comprise a noise threshold value and a peak width range; distinguishing the chromatographic peak into a normal peak or an abnormal peak by using the adjusted peak shape identification parameter; searching a liquid phase method optimization scheme matched with the morphological characteristic data of the abnormal peak in a preset optimization database, wherein the liquid phase method optimization scheme comprises gradient elution time adjustment, mobile phase proportion optimization or chromatographic column replacement suggestion; and sending the liquid phase method optimization scheme to a user. According to the invention, various abnormal peak shapes can be automatically and accurately identified, and the reliability and accuracy of identification are guaranteed.

The invention relates to the technical field of liquid chromatogram data processing, in particular to a liquid chromatograph state detection and maintenance method which comprises the following steps: establishing a multi-parameter online monitoring system which comprises a normal data set and an abnormal data set; learning the normal data set and the abnormal data set, and collecting real-time monitoring data to be matched with a known fault mode; according to the real-time monitoring data, the control unit draws a pressure curve and calculates a pressure fluctuation value; determining the test period of the chromatographic instrument based on the pressure fluctuation value and the baseline noise peak value, or sending an equipment fluctuation monitoring signal and calculating the difference value between the chromatographic column temperature and the environment temperature: determining the heating power of a constant-temperature box based on the difference value between the chromatographic column temperature and the environment temperature, or sending an equipment fluctuation monitoring signal; and determining the temperature correction coefficient of the chromatographic column according to the equipment vibration frequency. According to the invention, the operation stability and effectiveness of the liquid chromatograph are improved.

The invention discloses a fruit and vegetable exosome extraction method based on ligand fishing. The fruit and vegetable exosome extraction method comprises the following steps: suspending amino-functionalized Fe3O4 (at) SiO2 nanoparticles in a glutaraldehyde solution, and adding activated agglutinin to obtain Fe3O4 (at) SiO2-agglutinin nanoparticles; adding a glutaraldehyde solution into agarose gel to obtain a size exclusion chromatographic column filler; the method comprises the following steps: dispersing Fe3O4 (at) SiO2-lectin nanoparticles in a PBS buffer solution to obtain a uniform suspension, adding the uniform suspension into a size exclusion chromatographic column filler to obtain a uniform slurry, filling the size exclusion chromatographic column with the uniform slurry, and flushing with the buffer solution to form a magnetic bead stationary phase; and loading fruit and vegetable supernatant into a size exclusion chromatographic column, passing through the magnetic bead stationary phase, cleaning residual impurities combined on the exosome-magnetic bead compound by using a buffer solution, and dissociating the exosome from the magnetic beads by using a competitive eluent of the exosome to obtain the high-purity fruit and vegetable exosome. The problem that an existing exosome extraction method is difficult to meet the requirements of high efficiency, simplicity, high purity and high activity at the same time is solved.

The invention relates to a chromatographic instrument temperature control method and system, an intelligent terminal and a storage medium, and relates to the technical field of chromatographic instrument sample separation.The method comprises the steps that the sample type of a preset sample is obtained; analyzing the sample type to determine a window heating rate and a window target temperature; acquiring a chromatographic column initial temperature of a preset chromatographic column; analyzing the initial temperature of the chromatographic column and the target temperature of the window to determine the temperature of the chromatographic column needing to be increased; analyzing the temperature required to be increased and the window heating rate of the chromatographic column so as to determine the heating time of the chromatographic column; and controlling a preset chromatographic column temperature regulation and control device to perform temperature control on the chromatographic column according to the chromatographic column heating time and the window target temperature. The method has the effect of improving the precision of the temperature retention time.

The invention relates to a method for detecting and / or purifying a protein polymer and application thereof. The method comprises a step of detecting the protein polymer based on HPLC-SEC. The chromatographic conditions are as follows: a chromatographic column is a molecular size exclusion high performance liquid chromatographic column; and a PB buffer solution with the concentration of 50-200mM is used as a mobile phase. The method disclosed by the invention is good in separation degree, simple to operate, short in peak appearance time and short in detection time, and has good method reproducibility and stability.

The invention discloses a compound monitoring method and system based on chromatographic column analysis and a medium, and relates to the technical field of chromatographic detection.The method comprises the steps that a complex matrix sample is taken, and first chromatographic column response distribution of the complex matrix sample is collected through a diode array detector; enhancement strategy optimization is carried out according to adjustable action parameters of the diode array detector, and the diode array detector collects second chromatographic column response distribution of the complex matrix sample under a first enhancement strategy; identifying a difference chromatographic column response distribution of the first chromatographic column response distribution and the second chromatographic column response distribution, and constructing a high-dimensional feature fusion fingerprint; and performing similarity measurement based on the high-dimensional feature fusion fingerprints and a pre-constructed compound feature fingerprint database to obtain a compound detection result. The technical problem of low detection accuracy caused by insufficient chromatographic response information of the compound under a complex matrix condition in the prior art is solved, and the technical effect of improving the detection accuracy of the compound is achieved.

The utility model provides automatic medium-pressure preparation and separation equipment and an automatic separation and preparation system. The automatic medium-pressure preparation and separation equipment comprises a workbench; the sample loading, liquid adding and needle cleaning module, the column packing module, the fraction collecting module, the carrying mechanism and the pump valve module are arranged on the workbench; the mobile phase cache module, the sample loading liquid adding and needle cleaning module which are arranged independent of the workbench are used for sucking sample liquid and cleaning a sample loading needle; chromatographic columns and / or sample loading columns are installed on the column loading module through a carrying mechanism, samples are separated, and the chromatographic columns and / or the sample loading columns of various specifications can be arranged in the column loading module; the fraction collection module is used for collecting fractions; the carrying mechanism is used for transferring materials on the sample loading, liquid adding and needle cleaning module, the column packing module and the fraction collecting module; the mobile phase cache module caches the required mobile phase; and the pump valve module is respectively communicated with the sample loading, liquid adding and needle cleaning module, the column packing module, the fraction collecting module and the mobile phase caching module and is used for providing power for liquid transmission among the modules. According to the invention, automation and unmanned operation of the whole process of medium-pressure preparation and separation are realized.

The invention discloses a quantitative detection method for tobacco components. The quantitative detection method comprises the following steps: extracting a tobacco sample to obtain extract liquor; performing component analysis on the extracting solution by adopting high-resolution liquid chromatography-mass spectrometry to obtain a spectrogram of the tobacco sample; the high-resolution liquid chromatography mass spectrometry adopts two ion sources of an ESI source and an APCI source for detection, and the two ion sources both adopt reversed-phase chromatographic columns for detection; in detection, under the ESI source condition, positive and negative ion modes are adopted for scanning respectively, and under the APCI source condition, a positive ion mode is adopted for scanning. According to the quantitative detection method, two different ion sources are adopted, and high coverage and detection precision are both considered; corresponding chromatographic columns are adopted for liquid phase separation, separation of tobacco metabolism components with different properties in a complex natural tobacco matrix is facilitated, and the separation efficiency and the coverage degree are improved; by combining the ultrahigh resolution and high precision of the high-resolution liquid chromatography-mass spectrometry, the to-be-detected substance and the interfering substance are effectively distinguished, and the detection accuracy of various samples is improved.

The invention discloses a primary separation method and system of a liquid chromatography system.The method comprises the steps that a sample is pretreated according to physicochemical properties of a target sample, and a high-purity enriched sample is obtained; optimizing the composition proportion of the mobile phase according to the composition characteristics of the high-purity enriched sample to obtain the optimized mobile phase composition; selecting an optimal chromatographic column type according to the optimized mobile phase composition, and carrying out dynamic temperature control separation through a dynamic temperature control technology to obtain a high-selectivity separation condition; performing real-time detection on the separated chromatographic peak according to a high-selectivity separation condition to obtain a high-signal-to-noise-ratio detection signal; and evaluating the preliminary separation effect according to the high signal-to-noise ratio detection signal. By utilizing the embodiment of the invention, the enrichment efficiency and the separation selectivity of the sample can be improved, and the accuracy and the reliability of integral separation are further improved.

The invention provides a method for analyzing and identifying chemical components of a calculus-eliminating prescription, which comprises the following steps: S1, preparing a test solution: performing ultrasonic treatment on a calculus-eliminating prescription extract by using methanol, centrifuging, taking supernate, diluting, filtering, and taking subsequent filtrate to obtain the test solution; s2, analyzing the test sample solution by adopting UHPLC-QE-MS (Ultra High Performance Liquid Chromatography-Quantitative Enhanced-Mass Spectrometry), wherein the detection conditions of the UHPLC-QE-MS are as follows: a chromatographic column is an octadecylsilane chemically bonded silica chromatographic column; the column temperature is 20-40 DEG C; the flow rate is 0.1 to 0.5 ml / min; the mobile phase A is 0.03-0.20% v / v formic acid aqueous solution, the mobile phase B is acetonitrile, gradient elution is carried out, and the gradient elution procedure is 0-1 min, 5% B-> 5% B; in 1-14 minutes, 5% B is changed into 60% B; and after 14-15 minutes, 60% B is converted into 95% B. The detection method disclosed by the invention can identify 68 compounds in the calculus eliminating sample at one time, and is rapid, simple, convenient, high in sensitivity and good in specificity.

The invention discloses a method for determining bedaquiline fumarate clean verification target residues, and relates to the technical field of instrument analysis of chemical pharmacy. The method comprises the following steps: preparing a sample wiping solution; determining the content of bedaquiline fumarate in the sample wiping solution by adopting a liquid chromatography; chromatographic conditions are as follows: a chromatographic column is a VP-ODS C18 column; mobile phases: a potassium hexafluorophosphate aqueous solution and acetonitrile, wherein the concentration of the potassium hexafluorophosphate aqueous solution is 0.01-0.03 mol / L; the elution mode is isocratic elution; the flow rate is 1 ml / min to 2 ml / min; the column temperature is 28-32 DEG C; the method has good specificity and sensitivity for determination of bedaquiline fumarate cleaning verification target residues, is simple and convenient to operate, rapid in determination, simple and easy to implement, and overcomes the defects that TOC, chemical titration methods, conductivity methods, pH methods and the like which are commonly used at present do not have specificity.

The invention provides a method for measuring gamma-aminobutyric acid in tableted candies, which comprises the following steps: measuring gamma-aminobutyric acid in tableted candies by using HPLC-ELSD (High Performance Liquid Chromatography-Evaporative Light Scattering Detector) according to a volume ratio of acetonitrile to water of (50-70): (30-50) as a mobile phase; a chromatographic column is an amino column; a detector is ELSD, the temperature of a drift tube is 80-85 DEG C, and carrier gas is air. The detection method disclosed by the invention is strong in specificity, high in accuracy, strong in stability, good in repeatability and high in sensitivity, and compared with an existing derivation method, the method disclosed by the invention is simple, green and efficient, and can be used for effectively detecting the content of gamma-aminobutyric acid in the tabletted candies.

The invention discloses an ion trap mass spectrometry device and method capable of switching internal and external ion sources, and the device comprises an ion source cavity, the exterior of the ion source cavity is provided with a heating module, the side wall of the ion source cavity is provided with a sample introduction hole, and the sample introduction hole is internally provided with a chromatographic column I; the electron beam generation system is arranged at the front side position of the ion source cavity; the insulation connecting piece is communicated with the ion source cavity, and a lens I, a lens II and a lens III are sequentially arranged in the insulation connecting piece in the sample injection direction; a signal acquisition system; wherein a chromatographic column II is arranged on the ion trap. The two ionization modes inside and outside the trap are integrated, and different detection requirements can be flexibly met by switching the sample introduction path of the chromatographic column and regulating and controlling the voltage parameters of the lens I, the lens II and the lens III.

A chromatographic column packing machine comprises a machine box, a pneumatic pump is arranged in the machine box, a liquid outlet is formed in the side wall of the machine box, the liquid outlet is connected with the pneumatic pump through a pipeline, and the chromatographic column packing machine is characterized in that a pulsation damper is arranged on the pipeline. The flow pulsation damper has the beneficial effects that the flow pulsation damper is additionally arranged at the output end of the pneumatic pump, so that the flow pulsation can be effectively inhibited, the flow is kept stable while the column filling machine outputs displacing liquid at constant pressure, the column filling effect is improved, and the filling qualification rate of a chromatographic column is improved.

The invention relates to the technical field of analysis and detection, in particular to a method for determining residual epichlorohydrin in dihydroxypropyl theophylline. The residual epoxy chloropropane in the dihydroxypropyl theophylline is detected by adopting GC-MS (Gas Chromatography-Mass Spectrometer); chromatographic conditions are as follows: a chromatographic column is VF-624ms, 30m * 0.25 mm * 1.4 mu m; the carrier gas is helium, the column flow velocity is 0.95-1.05 ml / min, and the split ratio is 10: 1; the temperature of a sample inlet is 230-250 DEG C; the sample injection volume is 1 microliter; mass spectrum conditions are as follows: an ion source: EI; the temperature of the ion source is 220-240 DEG C; the temperature of a quadrupole rod is 140-160 DEG C; and the temperature of the auxiliary heater is 250-270 DEG C. Compared with the prior art, the analysis method provided by the invention has the advantages of high sensitivity, strong separation capability and rapidness, and can accurately quantify epichlorohydrin in the test sample.

The invention relates to a chromatographic technology, and particularly provides a PANs analysis device and method based on the chromatographic technology, the analysis device comprises a detector, a chromatographic column and a first quantitative loop, and the detector, the chromatographic column and the first quantitative loop are all connected with a port of a multi-ported valve; one end of the first pipeline is selectively connected with air and standard gas, the other end of the first pipeline is connected with a first port of the multi-way valve, one end of the second pipeline is connected with the chromatographic column, and the other end of the second pipeline is connected with a second port of the multi-way valve; the second quantitative ring is arranged on the first pipeline; under the switching of the flow path switching unit, the second port is communicated with the chromatographic column through a second pipeline or is communicated with the chromatographic column through the second pipeline, the second quantitative ring and the second pipeline in sequence, and the first port is connected with air or standard gas through a first pipeline. The method has the advantages of accurate measurement and the like, and is applied to air detection.

The utility model relates to a two-dimensional liquid phase system which comprises a hydrophilic interaction chromatographic column, a reversed-phase chromatographic column, a detector, an automatic sample injector, a first pump assembly, a second pump assembly, a sample temporary storage unit and a switching valve, the first pump assembly is communicated with the hydrophilic interaction chromatographic column and is used for pushing a sample loading solution and carrying out gradient elution on the hydrophilic interaction chromatographic column; the second pump assembly is communicated with the reversed-phase chromatographic column and is used for carrying out gradient elution on the reversed-phase chromatographic column; wherein the switching valve comprises a first double-four-way valve and a second double-four-way valve which are communicated with each other; the switching valve has at least two connection states through position switching: state 1: the switching valve communicates a liquid inlet of the detector with a liquid outlet of the hydrophilic interaction chromatographic column; and state 2: the switching valve communicates the liquid inlet of the detector with the liquid outlet of the reversed-phase chromatographic column, and communicates the first port of the sample temporary storage unit with the liquid inlet of the hydrophilic interaction chromatographic column. The system can realize one-time analysis of a multi-component target object with relatively large polarity difference.

The invention relates to a urine metabolism combined marker for diagnosing bladder cancer and a screening method of the urine metabolism combined marker. The urine metabolism combined marker is prepared from 2-methyl furan, dimethyl disulfide, octylene and acetophenone. The method for screening the urine metabolism combined marker comprises the following steps: carrying out chromatographic separation and mass spectrometry detection on a urine sample on the basis of a headspace automatic sampler in combination with a chromatographic column and a photochemical ionization time-of-flight mass spectrometry, preprocessing mass spectrometry data, and extracting spectrum peak data of metabolites in urine; the urine metabolism combination marker for diagnosing bladder cancer is obtained through further statistical analysis. The screening method of the urine metabolism combined marker for diagnosing the bladder cancer has the advantages of non-invasiveness, high-throughput detection, simplicity in operation and accurate result, and has a wide application prospect.

The invention relates to the technical field of environmental analysis and testing, and discloses a method for detecting perfluorinated compounds in soil, which comprises the following steps: (1) crushing and sieving a soil sample to be detected, then carrying out pressurized fluid extraction, carrying out rotary evaporation concentration on the obtained extract, and dissolving with methanol again to obtain a concentrated solution; (2) purifying the concentrated solution through a solid-phase extraction column, and then concentrating to a constant volume to obtain a to-be-detected solution; (3) detecting the type and the content of the perfluorinated compounds in the to-be-detected liquid by adopting a liquid chromatography-tandem mass spectrometry method; wherein in the step (1), an extracting solvent is a NaOH methanol solution; in the step (3), in the liquid chromatography-tandem mass spectrometry, the liquid chromatographic condition is as follows: a liquid chromatographic column is a C18 chromatographic column. The detection method provided by the invention is simple to operate, high in accuracy, good in repeatability, capable of analyzing multiple PFAS types (17 types) and low in detection limit, meets the analysis requirements, and can be used for analyzing and monitoring common PFAS in soil.

The invention discloses a detection method and a detection system for the cracking gas concentration of a transformer insulating material. The detection method comprises the following steps: performing headspace treatment on to-be-detected insulating oil to realize oil-gas separation in a sample; then the mixed gas is separated through a chromatographic column, the concentration of the dissolved gas is detected and analyzed through a mass spectrometry detector, and the cracking gas comprises at least one of methane, ethane, ethylene, acetylene, hydrogen, carbon monoxide or carbon dioxide. The method specifically comprises the following steps: preparing a to-be-detected insulating oil sample, and treating the to-be-detected insulating oil sample by adopting headspace to realize oil-gas separation in the sample; separating the mixed gas by adopting a chromatographic column, and then detecting and analyzing the dissolved gas by adopting a mass spectrometry detector; preparing a standard gas for dissolving the gas, establishing a calibration curve, and quantitatively calculating the concentration of the cracking gas through the calibration curve. The method can accurately detect methane, ethane, ethylene, acetylene, hydrogen, carbon monoxide and carbon dioxide gases, and has the characteristics of high detection sensitivity, good repeatability, simplicity and convenience and the like.

The purpose of the present invention is to provide a filler for a chromatography column, a chromatography column, a method for producing a chromatography column, a chromatography device, and an analysis method, which are suitable for separation or the like of a mixture containing various analytes. The column filler for chromatography is characterized in that the silanol group of silica contained in the filler is modified with a group represented by chemical formula (I). [Formula I]

The invention discloses an analysis device and an analysis method for total hydrocarbons and subitem hydrocarbons in oxygen. The analysis device comprises a first ten-way valve with ports a-j, a second ten-way valve with ports A-J, a first quantitative tube, a second quantitative tube, a first chromatographic column, a second chromatographic column, a third chromatographic column, a fourth chromatographic column and an FID (Flame Ionization Detector). According to the analysis device and the analysis method for the total hydrocarbon and the subitem hydrocarbon in the oxygen, samples can be simultaneously added into the two quantitative pipes through the same gas path, and the sample adding efficiency is improved. The arrangement of double valves and four columns can simultaneously analyze total hydrocarbons and subitem hydrocarbons, and the operation is simple and easy. Besides, before analysis, oxygen is separated and discharged out of a gas path, so that main peak interference under the oxygen background can be completely removed, the separation effect is good, the peak shape is uniform, and the test requirement is met.

The invention provides a method for detecting related substances of sucrose octasulfate salt auxiliary materials, and particularly relates to the field of medicines. An SCX cation exchange chromatography filler and a C18 filler are mixed according to the ratio of (0.8-1.2): (3-5) to serve as a filling agent; the specification of a chromatographic column is CAPCELLPAK CR C18 + SCX 5 [mu] m, 250 * 4.6 mml.D.; 18-22 mM / L ammonium formate and 0.08-0.12% formic acid are used as a mobile phase A, and acetonitrile is used as a mobile phase B; a detector is CAD, the spray temperature is High, the collection frequency half-peak width is 0.1-0.2 min, the column temperature is 28-32 DEG C, the flow rate is 0.8-1.2 ml / min, and the sample injection volume is 4-6 [mu] l; wherein acetonitrile and water in a ratio of (3-5): (5-7) are used as diluents, and gradient elution is carried out; the method provided by the invention can effectively separate and accurately analyze each impurity, has strong specificity and good separation degree, and can effectively control the product quality.

The present application is applicable to the field of medical devices, and discloses a liquid chromatography-mass spectrometry apparatus and a control method for the liquid chromatography-mass spectrometry apparatus. The liquid chromatography-mass spectrometry apparatus comprises a sample storage device, a pretreatment device, a chromatography device, a mass spectrometry detection device, and a controller. The chromatography device comprises a test solution preparation channel, a test solution transfer assembly, a liquid phase fluid delivery assembly, and a chromatography column. An operating pressure outputted by the liquid phase fluid delivery assembly is less than or equal to 20 MPa. The length of the chromatography column is greater than or equal to 3 mm and less than or equal to 35 mm. A sample comprises a target substance to be measured, and the target substance to be measured comprises at least one of vitamin D, a steroid hormone, and a catecholamine. The present application reduces costs of the liquid chromatography-mass spectrometry apparatus.

The utility model belongs to the technical field of gas chromatography detection, and discloses a portable gas chromatography analysis device with a pipeline storage function, which comprises a sample gas detection assembly and a chromatographic column communicated with the sample gas detection assembly through a gas pipe, and further comprises a winding assembly, the winding assembly comprises a winding disc, the winding disc comprises a first winding disc and a second winding disc, and the winding disc is connected with the sample gas detection assembly through a gas pipe. The first winding disc and the second winding disc are coaxially and fixedly connected through a fixing shaft. The supporting disc is rotationally connected with the first winding disc, and a plurality of through grooves are formed in the supporting disc in the circumferential direction of the circle center of the supporting disc; the number of the supporting plates is multiple, and the supporting plates are arranged in the through grooves in a sliding mode; the driving unit is used for driving the supporting plate to slide in the through groove; according to the scheme, the distance between each supporting plate and the circle center of the supporting disc is adjusted through the driving unit, and a diameter-variable winding space is formed; the portable gas chromatographic analysis device solves the problem that an existing gas chromatographic analysis device is poor in portability.

The application provides a construction method and application of a mistletoe preparation characteristic spectrum, wherein the construction method of the mistletoe preparation characteristic spectrum adopts a high performance liquid chromatography method to obtain a characteristic spectrum of a to-be-detected substance; and specific chromatographic conditions of the high performance liquid chromatography method are provided, wherein an octadecylsilane bonded silica gel is used as a filler of a chromatographic column; a detection wavelength is 248-252 nm; methanol is used as a mobile phase A, and a 0.09-0.11% phosphoric acid aqueous solution is used as a mobile phase B, and elution is performed according to a specific gradient program. The characteristic spectrum obtained by the construction method is comprehensive in material information, and fully represents key characteristic chemical components of the mistletoe preparation and common adulterated water extraction preparations of the mistletoe; differences in chemical components of the mistletoe and the preparation thereof and different adulterants characterized by the method can realize overall quality control of the mistletoe and identification of adulterated mistletoe.

The utility model provides a multi-mode automatic switching continuous sampling device of a liquid chromatograph-mass spectrometer, which relates to the technical field of scientific instruments and comprises three switching valves. A sample inlet of the switching valve A is connected with the liquid chromatography pump system, a sample outlet of the switching valve A is connected with an inlet of the first chromatographic column, and an outlet of the first chromatographic column is connected with a first sample inlet of the switching valve B; another sample outlet of the switching valve A is connected with an inlet of a second chromatographic column, and an outlet of the second chromatographic column is connected with a second sample inlet of the switching valve B; a first outlet of the switching valve B is connected with a first inlet of the switching valve C, and a second outlet of the switching valve B is connected with a second inlet of the switching valve C; and an outlet of the switching valve C is connected with a sample inlet of the mass spectrum system. According to the utility model, the three modes of first chromatographic column-mass spectrum, second chromatographic column-mass spectrum and second chromatographic column-ultraviolet-mass spectrum can be detected under the same acquisition instruction, so that the working efficiency of operators and the utilization rate of mass spectrometers are improved.

The present application relates to the detection method of peroxynitrate in the atmosphere, comprising: the six-way valve is adjusted to the sampling mode, the carrier gas and air inlet are opened, the carrier gas is swept to the chromatographic column and the electron capture detector in turn after passing through the first passage of the six-way valve, and the negative pressure device on the downstream side of the electron capture detector is opened at the same time; the air enters the sampling ring through the second passage of the six-way valve, and the excess air is discharged by using the air pump; the six-way valve is adjusted to the detection mode, the carrier gas enters the sampling ring through the third passage, the air sample in the sampling ring is taken out and brought into the chromatographic column; the PANs in the air sample are separated in the chromatographic column, and then enter the electron capture detector for detection, at the same time, the internal pressure of the electron capture detector is regulated and controlled by the negative pressure device to be stable negative pressure, the peak of the compound to be detected is accelerated, and the sensitivity of the electron capture detector to the detection is improved.