219results about How to "Improve particle size uniformity" patented technology

Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D₃ suitable for once-weekly dosing. Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.

Provided are nickel manganese composite hydroxide particles that are a precursor for forming cathode active material comprising lithium nickel manganese composite oxide having hollow structure of particles having a small and uniform particle size for obtaining a non-aqueous electrolyte secondary battery having high capacity, high output and good cyclability. When obtaining the nickel manganese composite hydroxide particles from a crystallization reaction, an aqueous solution for nucleation, which includes at least a metallic compound that contains nickel and a metallic compound that contains manganese, and does not include a complex ion formation agent that forms complex ions with nickel, manganese and cobalt, is controlled so that the temperature of the solution is 60 DEG C or greater, and so that the pH value that is measured at a standard solution temperature of 25 DEG C is 11.5 to 13.5, and after nucleation is performed, an aqueous solution for particle growth, which includes the nuclei that were formed in the nucleation step and does not substantially include a complex ion formation agent that forms complex ions with nickel, manganese and cobalt, is controlled so that the temperature of the solution is 60 DEG C or greater, and so that the pH value that is measured at a standard solution temperature of 25 DEG C is 9.5 to 11.5, and is less than the pH value in the nucleation step.

The invention provides a hollow organosilane microsphere with a rough surface structure and a preparation method thereof. The hollow organosilane microsphere with the rough surface structure is characterized by being prepared by the following steps of: providing an alkaline solution with the pH value of between 10 and 13; mixing at least two types of organosilane to obtain an organosilane mixture; adding the organosilane mixture into the alkaline solution; undergoing a hydrolytic polycondensation reaction; and standing and ageing. Organosilane microsphere particles are provided with folds on the surface and are hollow inside, and the particle sizes of the particles have high uniformity. The method provided by the invention is simple and feasible. By adopting the method, the problems of non-uniform particle size and breakage of a large number of sphere bodies caused by the conventional hollow microsphere preparation method can be solved.

The invention discloses an acoustic surface wave electronic cigarette system which comprises a piezoelectric substrate (1), a liquid guide cavity (2), an atomization cavity (3) and feed ports (4). Thefeed ports (4) are used for loading high-frequency signals. The liquid guide cavity (2) and the atomization cavity (3) are arranged on the upper side of the piezoelectric substrate (1); an isolationplate (13) is arranged between the liquid guide cavity (2) and the atomization cavity (3); the feed ports (4) are arranged on the outer side of the piezoelectric substrate (1). The acoustic surface wave electronic cigarette system has the advantages that aerosol generated by the acoustic surface wave electronic cigarette system by means of atomization has small particle sizes, accordingly, the acoustic surface wave electronic cigarette system is high in smoking comfort, and aroma is mellow and exquisite.

The invention discloses a preparation method of monodispersity micron-sized polysilicon microspheres which comprises the following steps: (1) adding deionized water and a basic catalyst in trialkoxysilane, and stirring in a nitrogen condition for hydrolysis; (2) centrifugally separating and filtering a mixed system in step (1) to remove unreacted monomers; and (3) adding the basic catalyst in a reaction system obtained from the step (2) for polycondensation, filtering, washing and drying to obtain the monodispersity micron-sized polysilicon microspheres. According to the method, the reaction temperature is low, the reaction can be conducted at room temperature, the synthesis steps are simple; the method does not use organic solvents which pollute the environment or emulsifiers in the reaction process, is simple in post treatment, less in types of raw materials, high in yield, and low in preparation cost, and can effectively adjust the grain size range of the microspheres to realize controllable sizes; and the obtained silicon microspheres are good in grain size uniformity and high in monodispersity, and has extremely good sphericity.

The invention discloses a method of improving the coercivity of sintering Nd-Fe-B magnetic materials. The method includes the following steps of using hydrogen to crush Nd-Fe-B alloy, powder processing, compression moulding, sintering and tempering under the protection of vacuum or protective gases. The sintering condition consists of heating to 300 to 600 DEG C, keeping the temperature for 5 to 6 hours to dehydrogenize, heating once again to 1060 to 1120 DEG C, sintering for 1 to 60 minutes under high temperature, finally decreasing the temperature to 1000 to 1050 DEG C, keeping sintering for 1 to 4 hours under the temperature and cooling. The method adopts the steps of sintering for a short period under high temperature to precipitate the liquid phase and then sintering under lower temperature. The liquid phase is rapidly precipitated under high temperature, thereby improving the sintering process of the magnetic materials, promoting the performance of sintering process, controlling the grain size through sintering under lower temperature, inhabiting grain growth and benefiting obtaining an excellent coercivity of magnetic materials.

The invention belongs to the field of medicines and relates to microemulsion. Particularly, the invention relates to microemulsion containing burdock aglycone and a microemulsion carrier, wherein the microemulsion carrier contains an oil phase and an emulsifier; and the average particle size of the microemulsion is 10 to 90 nanometers. The burdock aglycone microemulsion can improve the oral administration bioavailability and tumor suppressing effect of the burdock aglycone obviously.

The invention relates to a lithium-rich manganese-based precursor, a preparation method thereof and a lithium-rich manganese-based positive electrode material. The preparation method of the lithium-rich manganese-based precursor comprises the following steps: (1) dissolving nickel salt, cobalt salt, manganese salt and doping ion salt in water to obtain a mixed salt solution; (2) adding a precipitant and a complexing agent into the mixed salt solution, and adjusting the pH value to obtain a reaction precursor; and (3) carrying out intermittent ultrasonic vibration on the reaction precursor to obtain a lithium-rich manganese-based precursor crude product. According to the invention, the pH value of the reaction system is adjusted, so that the particle size of the material is in an increasingstage; the particle size in the reaction system is controlled by adopting intermittent ultrasonic concussion; when the particle size exceeds a control index, the ultrasonic oscillator is started, sothat nucleation of the reaction system is rapidly carried out, and the particle size is reduced; and when the particle size is reduced to a qualified standard range, the ultrasonic oscillator is turned off, so that the particle size of the lithium-rich manganese-based precursor is controllable.

Condensable vapors such as carbon dioxide are separated from light gases in a process stream. The systems and methods employ a particle bed cooled by an in-bed heat exchanger to desublimate the condensable vapors from the process stream. The condensable vapors are condensed on the bed particles while the light gases from the process stream, which are not condensed, form a separated light-gas stream. The separated light-gas stream can be used in a recuperative heat exchanger to cool the process stream.

The invention discloses a microcapsule with a silicon dioxide core-shell coating liquid and a preparation method of the microcapsule. The preparation method comprises the following steps of: selecting a polymer monomer A to prepare a polymer microsphere B with uniform grain size and having positive charge on the surface; absorbing a surface active agent onto the surface of the microsphere B to obtain a seed microsphere C; coating the seed microsphere C with tetraethoxysilane to obtain a microsphere D with porous silicon dioxide as a shell; calcining the microsphere D to obtain a hollow silicon dioxide microsphere E; soaking the hollow silicon dioxide microsphere E into liquid of a core material to obtain a microsphere F with the core material; coating the microsphere F with tetraethoxysilane to obtain the core-shell structured microcapsule G with dense silicon dioxide as the shell. The method is applicable to the preparation of the microcapsule coating low-polarity liquid, high-polarity liquid and dual-polarity liquid, solves the problem in the prior art that the dual-polarity liquid cannot be coated into the microcapsule, is simple in operation steps, and low in requirement for equipment, and the microcapsule is high in heat stability, good in corrosion resistance and uniformity of grain size.

The invention discloses a preparation method of a propofol fat emulsion injection. The preparation method comprises the following steps: uniformly mixing soybean oil, lecithin and oleic acid and adding propofol; spraying an oil phase into a water phase under the protection of nitrogen gas to prepare emulsion; shearing the emulsion to obtain primary emulsion; homogenizing the primary emulsion under the pressure of 10000psi-20000psi to prepare an emulsion semi-finished product; and filtering, inflating nitrogen and sterilizing to prepare the propofol fat emulsion injection. According to the preparation method, the grain diameter uniformity is enhanced and the disadvantage that the grain diameter deviation of the primary emulsion is too great is improved; the stability of finished-product emulsion is improved; the average grain diameter of the detected emulsion is 210nm-230nm and the grain diameter deviation is 0.20-0.30; the requirements on the grain diameters by the fat emulsion injection are met; the emulsion grains with the size being more than 1 micron are not detected, and the grain diameters are obviously better than the standards that the content of the emulsion grains with the size being 1 micron in emulsion large grains of national drug standards is not more than 3%; the physicochemical properties are stable, the toxic side effect is low, the pains caused by injection are reduced, and the compliance of using drugs by patients is increased, so that the application prospect is very good.

The present invention relates to a production method for a vinyl chloride-based resin having outstanding particle uniformity and heat stability, which is advantageous in that, by using an inorganic dispersion that has a specific structure while also being able to eliminate hydrogen chloride in a step in which a vinyl chloride resin is produced, a vinyl chloride resin will be produced that has outstanding particle uniformity and heat stability and also the thermal decomposition temperature of the resin is increased such that it is possible to even improve the product whiteness and physical properties during processing.

The atomizing formation apparatus for producing spherical casting WC powder includes low pressure inert gas intake assembly; furnace shaft containing the feeding mechanism, heater and graphite furnace tube; jetting and atomizing formation assembly containing beam current tube, inner and outer nozzles, high pressure inert gas supplying mechanism and atomizing formation barrel; and water cooling circulation mechanism. Owing to that the melt of the material in the protection of inert gas is acted by the high pressure inert gas flow to be jetted, atomized and formed into spherical powder, the produced spherical casting WC powder has compact structure and low cost. The technological process of the present invention is short, high in production efficiency, stable in product quality, low in power consumption and production cost and good in product using effect.

Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

The invention discloses a full-fat extruded soybean production device and a production technology. The full-fat extruded soybean production device comprises a bulk bin, an impurity removal working section, a first crusher and a second tee, wherein a material outlet of the second tee is connected with a peel suction device for removing soybean peels, and another material outlet of the second tee is connected with the first crusher; an arch breaking feeding bin is connected with a tempering device; the material outlet end of the tempering device is connected with an extruding machine; the material outlet end of the extruding machine is connected with a cooler; the material outlet end of the cooler is connected with a second crusher; another material outlet of a third tee is connected with the first crusher; the material outlet end of the second crusher is connected with a first rotary vibration grading sieve; the first rotary vibration grading sieve is connected with a first packaging device. The full-fat extruded soybean production device has the advantages that soybeans are firstly broken and then crushed, so that the productivity of the first crusher is increased, the abrasion of a hammer blade is reduced, and the crushing effect is improved; the peel suction device is used for separating soybean peels from soybean halves, so that the quality of a finished extruded soybean product is mainly improved.