This invention discloses the application of a Cav3.2 inhibitor in the preparation of a
drug for treating
intervertebral disc degeneration. Z944 can block the activation level of Cav3.2 in
nucleus pulposus cells, effectively alleviating
lipid metabolism disorders and cellular biological behavior disorders induced by abnormal mechanical stress, and ultimately reducing
intervertebral disc degeneration. This demonstrates that Z944 is a
drug with clinical application potential, which can be used to alleviate the pain and burden of patients with
low back pain and improve their
quality of life.