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49results about How to "Activate immunity" patented technology
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Recombinant antimicrobial peptide (AMP) as well as genetic engineering preparation method and application thereof
InactiveCN102220255AHigh antibacterial activityExpress system securityAntibacterial agentsBiocideBiotechnologyDisease
The invention provides a preparation method and application of a recombinant antimicrobial peptide (AMP) and belongs to the technical field of biological genetic engineering. The method comprises: amplification of an antibacterial peptide gene, gene cloning, transformation of beer yeast and efficient expression and purification of recombinant protein. The recombinant AMP provided by the invention is AMP-36 of the porcine Cathelicidins family, and the protein of the recombinant AMP contains short peptide shown by the sequence ID No.2. By utilizing the method provided by the invention, the prepared recombinant AMP can be used for producing a feed additive, a veterinary medicine and a preservative and preparing Gram-negative bacteria, Gram-positive bacteria and medicaments for diseases caused by fungi or virus.
Owner:SHENZHEN SUNSMILE BIOTECH
Composition comprising recombinant fusion protein of pathogenic antigen protein and flagellin of vibrio vulnificus for preventing, alleviating, or treating aging
InactiveUS20160083437A1Preventing and improving and treating agingPreventing and improving and treating metabolicBacterial antigen ingredientsPeptide/protein ingredientsFlagellinArcobacter
The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
Owner:IND FOUND OF CHONNAM NAT UNIV
Traditional Chinese medicine plaster for treating malignant tumors and preparation method and application thereof
ActiveCN101618188ANo side effectsAvoid side effectsAmphibian material medical ingredientsAnthropod material medical ingredientsMyrrhHydrothorax
The invention provides a traditional Chinese medicine plaster for treating malignant tumors, which is prepared from the following raw materials by weight portion: 80-130 portions of euphorbia pekinensis, 80-130 portions of euphorbia kansui, 80-130 portions of lilac daphne flower bud, 80-130 portions of rhizoma sparganii, 80-130 portions of rhizoma zedoariae, 60-100 portions of frankincense, 60-100 portions of golden cypress, 60-100 portions of rhizoma coptidis, 60-100 portions of rhubarb, 60-100 portions of myrrh, 40-70 portions of nux vomica, 40-70 portions of Chinese gall, 40-70 portions of pillis ophidiae, 40-70 portions of angelica, 40-70 portions of liquorice, 40-70 portions of dried rhizome of rehmannia, 40-70 portions of radix scrophulariae, 40-70 portions of radices trichosanthis, 40-70 portions of fiveleaf akebia fruit, 35-55 portions of centipede, 35-55 portions of scorpio, 35-55 portions of pseudo-ginseng and 35-55 portions of senso. The invention also provides a preparation method of the traditional Chinese medicine plaster. The traditional Chinese medicine plaster is used for treating various malignant tumors, is a preferred plaster for patients with end-stage tumors, i.e. hydrothorax, ascites, jaundice, and the like and has the advantages of innocuity, high safety, low cost, convenient preparation, and the like.
Owner:李文灏
Medicine for treating gastric cancer
InactiveCN101804171AEnhance the immune function of the bodyImprove clinical symptomsAnthropod material medical ingredientsMammal material medical ingredientsCentipedeRemove blood
The invention relates to the field of pure traditional Chinese medicines, in particular to a medicine for treating gastric cancer. The invention solves the problems of the prior traditional Chinese medicine for treating gastric cancer, such as poor curative effect, long treatment course, incapability for radical cure and the like. The medicine consists of fried bighead atractylodes rhizome, Indian buead, grassleaf sweelflag rhizome, nutgrass galingale rhizome, sarcandra glabra, scorpion, dried orange peel, officinal magnolia bark, noble dendrobium stem, dried lily bulb, dwarf lilyturf tuber, Chinese angelica, grub, liquoric root, raw chicken's gizzard-membrane, cattail pollen, bletilla, pseudo-ginseng, fiveleaf akebia fruit, American ginseng, pinellia tuber, fructus amomi, nutmeg, centipede, safflower, barbed skullcap herb and Chinese paris rhizome. The medicines can cooperate with one another, effectively exert respective pharmacological effects, make up for one another's deficiencies, have a synergistic effect, enhance the efficacy and have the effects of tonifying the spleen and Qi, invigorating the circulation of blood and nourishing the kidney, promoting blood circulation to remove blood stasis and dissipating stagnation; and when being used for treating gastric cancer, the medicine can enhance the immunity of the body, improve the clinic symptom of a patient and treat the primary and the secondary symptoms at the same time, and has the advantages of remarkable and assured curative effect, quick curative effect, short treatment course, no toxic side effect and low treatment cost.
Owner:白如冰
Multifunctional water supplement aqueous solution for livestock and poultry and preparation method thereof
InactiveCN108354068AImprove survival rateImprove farming efficiencyAccessory food factorsFood gradeImproved survival
The present invention relates to a multifunctional water supplement aqueous solution for livestock and poultry and a preparation method thereof. The water supplement aqueous solution comprises the following raw materials in parts by weight: 20-25 parts of anhydrous glucose, 10-15 parts of lactic acid, 10-20 parts of citric acid, 2-4 parts of potassium chloride, 3-5 parts of sodium chloride and 40-70 parts of water; the used measurement standard for each component is based on the anhydrous glucose as food grade, lactic acid purity is larger than or equal to 95%, citric acid purity is larger than or equal to 99%, potassium chloride purity is 98.5% and sodium chloride purity is 99.5%; and use amounts of the lactic acid and citric acid enable a pH value of the water supplement aqueous solutionto be 2.8-3.5. The preparation method is as follows: 1) according to the component ratios, the glucose, lactic acid, citric acid, potassium chloride, sodium chloride and water are weighed; 2) firstly, the glucose, citric acid and 70% water are mixed evenly; and then the potassium chloride and sodium chloride are added for mixing; and 3) after the raw materials are mixed, then 30% of the remainingwater is added; then steam heating is conducted to 50-70 DEG C; stirring is conducted for 20-30 minutes; then the lactic acid is added; then the stirring is conducted for 5-10 minutes; and the preparation is completed. The multifunctional water supplement aqueous solution can significantly improve survival rate and breeding efficiency of the livestock and poultry.
Owner:张继成
Formula of biological feed additive capable of resisting diseases and promoting growth
The invention discloses a formula of a biological feed additive capable of resisting diseases and promoting growth. The formula is simple in process and good in using effect, and includes the following raw materials in percentage: 90% of feedstuff, 5% of bacillus, 3% of yeast and 2% of lactic acid bacteria. The preparation process includes the following steps: preparing materials, mixing, fermenting and packaging. The core technology of the invention is that three types of bacteria, namely the bacillus, the yeast and the lactic acid bacteria, are added, wherein the lactic acid bacteria adheres to the stomach and intestine of animals for promoting digestion; yeast only adheres to the intestine, is free of infection by any other bacteria, can infect other bacteria and resist harmful bacteria, and promotes intestinal absorption; and in addition, zymosan, a metabolite generated with yeast, is contained, and as a plant polysaccharide, the zymosan is an immune activator, and can activate the immunity of animal bodies, improve disease resistant capabilities of animals and reduce the incidence; as growth inhibiting bacteria, the bacillus can kill and inhibit various harmful bacteria and pathogens in the animal bodies and helps the animals break down and digest food.
Owner:WUHAN JINHE TECH DEV
Efficient targeting nanovaccine vector, preparation method thereof, targeting nanovaccine and preparation method thereof
ActiveCN111298128AEfficient activationEnhance cross-presentationCancer antigen ingredientsPharmaceutical non-active ingredientsAdjuvantArginine
The invention provides an efficient targeting nanovaccine vector. The efficient targeting nanovaccine vector comprises a linear poly(alpha-lysine); the linear poly(alpha-lysine) is grafted with mannose and arginine protected by p-toluenesulfonyl, wherein a molar ratio of the linear poly(alpha-lysine) to the arginine protected by the p-toluenesulfonyl is 1:(10-100), and a molar ratio of the linearpoly(alpha-lysine) to the mannose is 1:(1-30). According to the invention, electropositive Man-PLL-RT molecules are used as the targeting vaccine vector to support an electronegative antigen and an adjuvant, and the targeting vaccine vector can effectively improve endocytosis efficiency of the antigen and the adjuvant in BMDCs, and meanwhile, can efficiently activate the BMDCs, improve the cross-presentation effect of the antigen and activate in-vivo immunoreaction. The invention further provides a preparation method of the efficient targeting nanovaccine vector, a targeting nanovaccine and apreparation method of the targeting nanovaccine.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Composite microbiological preparation for antibiotic-free breeding and three-dimensional epidemic prevention of live pigs and preparation method and application of composite microbiological preparation for antibiotic-free breeding and three-dimensional epidemic prevention of live pigs
InactiveCN110923170AActivate immunityRealize epidemic prevention and controlFungiBacteriaAnimal scienceOrganism
The invention discloses a composite microbiological preparation for antibiotic-free breeding and three-dimensional epidemic prevention of live pigs and a preparation method and application of the composite microbiological preparation for antibiotic-free breeding and three-dimensional epidemic prevention of live pigs. The preparation is prepared by mixing candida utilis with brevibacillus brevis, lactobacillus plantarum, streptococcus thermophilus, rhodopseudomonas palustris and the like. The composite microbiological preparation has the functions of physical isolation, purification of environment, activation of organism mucosal immunization, regulation of intestine microbiological balance and the like, epidemic disease control for the breeding process of the live pigs can be realized frommultiple angles of air, padding, and digestive tracts, the healthy growth of the live pigs is guaranteed, and the purpose of antibiotic-free pork production is realized.
Owner:福建大用投资有限公司
Fish feed
InactiveUS20150173400A1Promote growthEfficient growth processProtein composition from fishAnthropod material medical ingredientsDiseaseFish growth
Due to the recent problems of higher fuel costs and exhaustion of marine resources, fish meal-free feeds have been developed. However, these feeds are insufficient from the standpoints of feed-intake and growth of fishes. Also, there has been required a feed which can economically and easily prevent or treat fish diseases and, even in the case of given in a reduced amount, ensures efficacious fish growth without disturbing the growth of fishes. Disclosed is a feed containing fly pupae and / or fly larvae. This feed can be taken at a high feeding rate by fishes, promotes the growth of the fishes having taken the same and exerts an effect of activating the immunity of the fishes.
Owner:NAT UNIV CORP EHIME UNIV +1
Herbal tea pill and preparation method thereof
InactiveCN104147428AHeat-clearing and detoxifyingWith dampness and swellingNervous disorderAntipyreticMedicinal herbsMenthol
The invention discloses an herbal tea pill and a preparation method thereof. The herbal tea pill includes, by a certain weight parts, helictercs angustifolia, dendranthema indicum, centella asiatica, ilex asprella roots, radix glycyrrhizae, lysimachia christinae, elephantopus scaber, folium microcotis, emilia sonchifolia and couchgrass roots. The preparation method includes following steps: mixing and decocting the ilex asprella roots and the helictercs angustifolia; mixing filtrates; concentrating the filtrates; adding honey and menthol to a concentrated liquid; uniformly mixing and crushing the dendranthema indicum, the centella asiatica, the radix glycyrrhizae, the lysimachia christinae, the elephantopus scaber, the folium microcotis, the emilia sonchifolia and the couchgrass roots to obtain a mixture; enable the mixture to pass through a molecular sieve to obtain a fine powder; spraying the standby concentrated solution into the fine powder; preparing pills; enabling the pills to pass through the molecular sieve to obtain wet pills; drying the wet pills; coating the wet pills and polishing the wet pills to obtain a finished product. The herbal tea pill is not only good in maintenance of medicine functions but also sweet in taste. Defects that a convention decoction herbal tea is bitter in taste, is difficult to drink and is not portable are overcome.
Owner:广西梧州三鹤药业股份有限公司
Active flora traditional Chinese medicine fermentation product for replacing feed antibiotics and preparation method of fermentation product
PendingCN110200132AAnti-infective microbiomeNutritious microecologyAntibacterial agentsFood processingAntibiotic YDrug resistance
The invention discloses an active flora traditional Chinese medicine fermentation product for replacing feed antibiotics. The fermentation product is formed by adding active flora into traditional Chinese medicine components and core materials for fermentation. The invention further discloses a preparation method of the active flora traditional Chinese medicine fermentation product for replacing feeding antibiotics, and the method includes three steps of raw material preparation, fermentation through core substance addition and secondary fermentation. The fermentation product prepared by the method is immune anti-infection microecological traditional Chinese medicine fermentation, has the effects of anti-infection microecology, immune microecology, nutritional microecology and environmental microecology, is pure in biological components, is safe, environment-friendly, zero drug resistance and pollution-free.
Owner:怀化尚玉成农牧科技有限公司
Antitumor effect potentiator
PendingCN112805020AActivate immunityPrevent recurrenceOrganic active ingredientsMilk preparationTumour immunotherapyActive ingredient
Provided is a novel means for activating an immune response in tumor immunotherapy in which an immune checkpoint inhibitor is used. An immune-checkpoint-inhibitor antitumor effect potentiator having probiotics and prebiotics as active ingredients.
Owner:NAT CEREBRAL & CARDIOVASCULAR CENT +1
Traditional Chinese medicine compound preparation for treating cancers
ActiveCN104127684ACompletely curedTo promote metabolismKetone active ingredientsAntineoplastic agentsSide effectPatient compliance
The invention provides a traditional Chinese medicine compound preparation for treating cancers. The preparation is prepared from the following raw medicinal materials in parts by weight: 110-130 parts of curcumin, 10-30 parts of subprostrate sophora extracts, 30-50 parts of sealwort extracts, 10-30 parts of fructus forsythiae extracts, 10-30 parts of radix bupleuri extracts, 10-30 parts of ligusticum wallichii extracts and 10-30 parts of pinellia ternate extracts. The preparation provided by the invention is high in curative effect, low in cost, convenient and efficient to use, free from toxic and side effects and high in patient compliance.
Owner:杨全江
Oral cancer nano vaccine and structuring method thereof
ActiveCN102058879AImprove import efficiencyAmplify the anti-tumor immune effectPharmaceutical non-active ingredientsEmulsion deliveryAntigenCross-link
The invention provides an oral cancer nano vaccine and a structuring method thereof. The vaccine comprises a water-in-oil type nano-emulsion cancer vaccine and tomato lectin which is modified on the surface of the water-in-oil type nano-emulsion cancer vaccine through a cross-linking agent of phosphatidyl ethanolamine. The structuring method comprises the steps of: 1, preparing the water-in-oil type nano-emulsion cancer vaccine; 2, synthesizing tomato lectin-phosphatidyl ethanolamine; and 3, modifying the surface of the nano-emulsion cancer vaccine. In the oral cancer nano vaccine provided by the invention, the tomato lectin is combined with intestinal tract cells M in a specific targeting manner, which is favorable for effectively improving vaccine absorptivity and activating mucous membrane and whole body dual immune; a nano emulsion is used as a vector for the vaccine so as to ensure that the vaccine effectively passes through an enzymatic barrier and a membrane barrier, and improve the bioavailability of the oral vaccine; and a superantigen SEA component is added into a cancer antigen, which is favorable for effectively activating cells CD4+T at the same time of activating cells CD8+T, and the superantigen SEA component and the cancer antigen take effect synergistically to enhance the immune effect of the cancer antigen.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Composite dietary fiber formula powder and preparation method thereof
The invention discloses composite dietary fiber formula powder. The formula powder comprises the following components in parts by weight of 30-50 parts of polydextrose, 20-45 parts of inulin and 1-50parts of oligosaccharide. A preparation method of the formula powder comprises a material preparation step of preparing the following raw materials in parts by weight of 30-50 parts of the polydextrose, 20-45 parts of the inulin and 1-50 parts of the oligosaccharide, a crushing step of crushing large-particle substances in the raw materials, a screening step of screening the polydextrose, the inulin and the oligosaccharide to obtain to-be-mixed materials, and a mixing step of mixing the to-be-mixed materials to obtain the formula powder. The formula powder is helpful for adding the intestinalfunctions and improving intestinal flora.
Owner:浙江核力欣健药业有限公司
Functional plant solid beverage and preparation method thereof
PendingCN112868970AImprove immunityActivate immunityFood ingredient functionsProtein food ingredientsBiotechnologyPolygonum odoratum
The invention discloses a functional plant solid beverage and a preparation method thereof. The functional plant solid beverage is prepared from, by mass, 15% of sea-buckthorn, 15% of white mulberry, 12% of dandelion, 12% of radix polygonati officinalis, 12% of rhizoma polygonati, 30% of black fruit small molecule peptide, 1% of riboflavin and 3% of monosaccharide. The preparation method comprises the following steps: weighing the hippophae rhamnoides, the white mulberry, the dandelion, the radix polygonati officinalis, the rhizoma polygonati, the black fruit small molecule peptide, the riboflavin and the monosaccharide according to the mass ratio; respectively baking sea-buckthorn, white mulberry, dandelion, polygonatum odoratum, polygonatum kingianum, black fruit small molecule peptide, riboflavin and monosaccharide at low temperature for more than 24 hours for later use; putting the baked components in parts by weight into a high-speed pulverizer for wall breaking treatment, and sieving with a 80-100-mesh sieve to obtain superfine mixed powder. The invention can rapidly, remarkably and effectively dissolve fat and thrombus, reduce cholesterol and supplement various trace elements required by a human body.
Owner:辽宁百草园饮品有限公司
Composition comprising recombinant fusion protein of pathogenic antigen protein and flagellin of vibrio vulnificus for preventing, alleviating, or treating aging
ActiveUS20180118792A1Preventing and improving and treating agingPreventing and improving and treating metabolicBacterial antigen ingredientsPeptide/protein ingredientsADAMTS ProteinsFlagellin
The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
Owner:MEDISPAN CO LTD
Herbal rejuvenating energy cream and preparation method thereof
InactiveCN111329821AVigorous and healthyImprove disease resistanceCosmetic preparationsToilet preparationsChemistryGlycerol
The invention provides a herbal rejuvenating energy cream and a preparation method thereof, and belongs to the technical field of medicines. The preparation method of the herbal rejuvenating energy cream comprises the following steps: pulverizing 36 traditional Chinese medicines such as rhubarb roots and safflowers to obtain powder; screening the powder by using a 200-mesh sieve, soaking the screened powder with sesame oil of which the weight is 50 times of the weight of the powder for 4 days to 6 days, and collecting clean oil of an upper layer; adding 15g to 25g of glycerol, 30g to 35g of beta-carotene, 30g to 40g of carrot extract and 10g to 20g of glyceryl stearate into 1000 milliliters of the clean oil to obtain a mixture; then uniformly stirring the mixture; and performing standing and cooling at room temperature until the mixture is condensed so as to obtain the herbal rejuvenating energy cream. The herbal rejuvenating energy cream is prepared by adopting the method disclosed bythe invention, an external application way is adopted, accompanied by a massaging way, and the cream is fully absorbed; and traditional Chinese medicine components are not added with chemicals, so that the cream has the effect of improving the human body immunity. In the preparation method, by using the sesame oil as a solvent, emulsification is not required, and addition of lubricants is also not required.
Owner:葛曙明
Innovative whitening, brightening and freckle-removing cream and preparation method thereof
The invention belongs to the field of daily chemicals. The invention discloses innovative whitening, brightening and freckle-removing cream. The innovative whitening, brightening and freckle-removing cream comprises the following components: cetostearyl alcohol / cetearyl glucoside, glyceryl stearate / PEG-100 stearate, squalene, caprylic acid / capric triglyceride, tocopherol, 1618 alcohol, bisabolol, phytosterol, glycerol, propylene glycol, xanthan gum, allantoin, sodium hyaluronate, salicylic acid, beta cyclodextrin, glucose, tranexamic acid, biological compound enzyme, cyclopentasiloxane / cyclohexasiloxane, isopropyl myristate, glycyrrhiza flavonoids, dimethyl methoxy benzodihydropyranol, 1,3-butanediol, a licorice root extract, Vc and derivatives thereof, glabridin polypeptide, and the balance of water. The freckle-removing cream is based on the bionics principle, mainly adopts natural components close to a human body as main components, and is mild, non-irritant, safe, free of toxic and side effects and free of dependence, and after the freckle-removing cream is used, the skin is not allergic, red, swollen or peeled.
Owner:广州市中科医美生物科技有限公司
Medicament for treating female genital tract virus infection and preparation method of sustained-release preparation of medicament
ActiveCN102008628BBlock replicationInhibition of replicationOrganic active ingredientsPeptide/protein ingredientsSide effectOpuntia ficus Extract
The invention discloses a medicament for treating female genital tract virus infection and a preparation method of a sustained-release preparation of the medicament. The medicament is prepared by the following raw materials of aloe extract, banlangen extract, cactus extract, antiviral bioactive material, an immunoreactive and stable protective agent and a polymer carrier. The preparation method comprises the steps of respectively producing the aloe extract, the banlangen extract, the cactus extract and the antiviral bioactive material into a solid substance; and then producing the solid substance with other accessories into various sustained-release preparations. The invention provides the medicament for treating the female genital tract virus infection and the preparation method of the sustained-release preparation of the medicament, wherein the medicament can effectively prevent and clear female genital tract viruses and has accurate curative effects and no stimulating effect or side effect on skin and mucosa and can be safely and reliably used for treating the female genital tract virus infection.
Owner:海南森瑞谱生命科学药业股份有限公司
Anti-cancer drug composition and preparation method thereof
InactiveCN102698257AGood attackImprove anti-cancer effectPowder deliveryPeptide/protein ingredientsSide effectCancer cell
The invention relates to an anti-cancer drug composition. The anti-cancer drug composition comprises active ingredients: NDV (Newcastle Disease Virus) particles and NA (neuraminidase), and the activity of NDV is 10<6>-10<7> PFU / ml, and the activity of NA is 0.01-0.02u / ml. The anti-cancer drug composition has the advantages of wide anti-tumor spectrum, and obvious therapeutic effect, no obvious toxic or side effect, immunization, and direct killing effect on cancer cells. The invention further provides a preparation method of the anti-cancer drug composition.
Owner:张炳团
Vanilla extract for activating organism immunity and preparing method and application thereof
InactiveCN106511786AKeep active ingredientsActivate immunityCosmetic preparationsToilet preparationsBiotechnologyAdditive ingredient
The invention provides vanilla extract for activating organism immunity and a preparing method and application thereof. The vanilla extract is composed of vanilla essential oil and vanilla distillate. Vanilla varieties comprise eupatorium fortunei, menthapiperita and cymbopogon citratus. The vanilla essential oil and the vanilla distillate are obtained by distilling fresh blades of eupatorium fortunei, menthapiperita and cymbopogon citratus through steam. The vanilla extract for activating the organism immunity can be added into beverages to manufacture vanilla distillate drinks, or added into soap bases to manufacture vanilla health soap, or added into cosmetic matrix to manufacture emulsion and cream. The effective ingredients of the extract are compounded according to different vanilla essential oil characteristic aroma components and effect optimization, and active ingredients, nutritious ingredients and aroma ingredients contained in the vanilla extract have a synergistic effect and are beneficial for activating the organism immunity. The vanilla extract is applied to the beverages, the soap bases or skincare products and can promote and maintain organism health.
Owner:PEILAN BIOTECH SHANGHAI CO LTD
Preparation method of collagen active peptide for inhibiting cancer cell proliferation
PendingCN114213529ASolve the phenomenon of disintegrationReduce control requirementsConnective tissue peptidesPeptide preparation methodsBone marrowCancer cell proliferation
The invention discloses a preparation method of collagen active peptide for inhibiting cancer cell proliferation, relates to the technical field of protein and polypeptide preparation, and particularly relates to 80-100 parts of bone collagen peptide, 5-15 parts of bovine bone marrow peptide, 1-3 parts of inulin, 0.5-1.5 parts of acerola cherry fruit powder, 10-30 parts of taurine, 5-15 parts of vitamin B1, 5-10 parts of vitamin B2 and 2-4 parts of vitamin B6. According to the preparation method of the collagen active peptide for inhibiting cancer cell proliferation, micro-vibration with the vibration amplitude within 0.5 cm is carried out on a material disc containing materials in the freeze-drying process, so that a solution continuously fluctuates under the vibration effect, the solution is subjected to freeze-drying in the fluctuating process, the disintegration phenomenon is solved, and the cancer cell proliferation is inhibited. A closed escape passage of water vapor at the lower layer is avoided, so that the control requirement on the disintegration temperature is reduced, the drying speed of the solution is indirectly accelerated, the solution is limited by the molecular film when fluctuating and is prevented from falling out of the material disc, and meanwhile, escape of the water vapor is not hindered by the molecular film.
Owner:山东美之健医药科技有限公司
Oral cancer nano vaccine and structuring method thereof
ActiveCN102058879BImprove import efficiencyAmplify the anti-tumor immune effectPharmaceutical non-active ingredientsEmulsion deliveryCross-linkAntigen
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
A light-responsive engineered bacteria intestinal targeting optogenetic carrier system and its construction method and application
ActiveCN111557918BUniform shapeGood dispersionPowder deliveryPeptide/protein ingredientsMicrosphereBowels diseases
The invention relates to a light-responsive engineering bacteria gut-targeted optogenetic carrier system. The system is a blue-light-responsive engineering bacteria BL21@pH-sensitive microsphere-carrying rare earth nanomaterial@acid-alkaline-enzyme-stabilized two-component microspheres The two-component microspheres are engineering bacteria BL21@alginate microspheres loaded with rare earth nanomaterials@acid-alkaline-enzyme stable microspheres uniformly coated with chitosan. The light-responsive engineering bacteria intestinal optogenetic carrier system of the present invention is a blue light-responsive engineering bacteria BL21@pH-sensitive microsphere-carrying rare earth nanomaterial@acid-base-enzyme-stabilized two-component microspheres, with uniform morphology and good dispersibility , which can target inflammatory bowel disease lesions and simultaneously release blue-light-responsive engineered bacteria BL21 and rare earth nanomaterials@acid-alkaline-enzyme-stabilized microspheres, using "optogenetic technology" to achieve precise and effective colonization of exogenous engineered bacteria, further To achieve the relief and treatment of inflammatory bowel disease.
Owner:TIANJIN UNIV
Peptide having high affinity for pd-l1 protein and use thereof
ActiveUS20210230286A1Reduced growth rateProlong survival timePeptide/protein ingredientsImmunoglobulins against cell receptors/antigens/surface-determinantsHuman tumorImmunity
The present invention provides a peptide having high binding affinity for PD-L1 protein and use thereof. The peptide has an amino acid sequence of SEQ. ID. NO. 1, SEQ. ID. NO. 3 or SEQ. ID. NO. 4, or the peptide is a tandem or branched peptide with a single repeat or multiple repeats of SEQ. ID. NO. 1, SEQ. ID. NO. 3 and SEQ. ID. NO. 4 and has an amino acid sequence of SEQ. ID. NO. 5. The peptide can bind to human PD-L1 with high affinity, competitively block the affinity of PD-1 / PD-L1 protein, block the negative regulatory tolerance pathway of human tumors, activate immunity and increase the lethality of T cells against tumor cells.
Owner:ZHU NAISHUO +1
GalNAc/CpG liposome vaccine with anti-tumor activity as well as preparation method and application of GalNAc/CpG liposome vaccine
ActiveCN113499433AImproving immunogenicityThe synthesis steps are simpleCancer antigen ingredientsCarrier-bound antigen/hapten ingredientsAntiendomysial antibodiesAdjuvant
The invention discloses a GalNAc / CpG liposome vaccine with anti-tumor activity as well as a preparation method and application of the GalNAc / CpG liposome vaccine. The vaccine comprises a Tn antigen GalNAc, cholesterol and a nucleic acid adjuvant CpG ODN. According to the invention, a Chol-GalNAc compound is constructed through a Click reaction, the components of the vaccine can be clearly represented, and the vaccine has the characteristic of biodegradability. The liposome vaccine entrapped with the adjuvant CpG ODN is constructed through a film-ultrasonic method, the purpose of antitumor activity of body fluid and cellular immunity can be achieved, and the liposome vaccine plays a role as a main active component in preparation of drugs for resisting breast cancer and the like. Experiments prove that the GalNAc / CpG liposome vaccine has a good particle size, can well induce maturation of bone marrow derived BMDCs and spleen B cells of mice and induce the mice to generate specific antibodies, and can effectively activate cellular immunity of the mice to realize an anti-tumor effect.
Owner:FUDAN UNIV
Wind-dispelling and bone-penetrating ointment and preparation method thereof
InactiveCN112915180AEliminate inflammationQuick effectHydroxy compound active ingredientsAntipyreticRheumatismOsteoproliferation
The invention provides a wind-dispelling and bone-penetrating ointment and a preparation method thereof. The wind-dispelling and bone-penetrating ointment comprises traditional Chinese medicine raw materials, wherein the traditional Chinese medicine raw materials are mainly prepared from the following raw materials by weight: radix paeoniae rubra, radix angelicae pubescentis, peach kernels, radix curcumae, ground beetles, dipsacus roots, herba taxilli, unprocessed radix aconiti carmichaeli, radix angelicae sinensis, eucommia ulmoides, radix achyranthis bidentatae, herba schizonepetae, radix saposhnikoviae, cassia twigs, herba ephedrae, radix morindae officinalis, flos carthami, radix cynanchi paniculati, cornu cervi slices, resina draconis, borneol, frankincense, myrrh, musk, camphor camphor dan, sesame oil, black cocks and geckos. The wind-dispelling and bone-penetrating ointment and the preparation method thereof acts on rheumatism, rheumatoid, arthritis, hyperosteogeny and neck and shoulders, has the advantages of dispelling wind, activating collaterals, eliminating inflammation and toxin for lumbocrural pain, quickly taking effect, relieving swelling, settling pain, recovering functions, easing joint movement, activating immunity, promoting blood circulation, removing blood stasis, strengthening body resistance and eliminating evil, and the wind-dispelling and bone-penetrating ointment and the preparation method thereof is reasonable and simple in formula, easy to prepare and good in treatment effect.
Owner:秦秀同
Composition for Promoting Production of Immunostimulatory Factor
ActiveUS20190290674A1Easy to produceActivate immunityPowder deliveryOrganic active ingredientsDiseaseViral disease
According to the present invention, various diseases, such as viral diseases, cancer, and multiple sclerosis, can be prevented and improved by using an immunostimulatory factor production-promoting composition comprising genomic double-stranded RNA of a plant-derived endornavirus.
Owner:KYOTO UNIV
Compound sedum sarmentosum capsules and preparation method thereof
InactiveCN101385765AHigh affinityStrong integrationDigestive systemAntiviralsChronic hepatitisToxic material
The invention provides a complex stringy stonecrop herb capsule and a preparation method thereof. The complex stringy stonecrop herb capsule, the active ingredients of which consist of medicinal materials such as stringy stonecrop herb and Japanese ardisia herb, has the effects of removing heat and toxic substance, invigorating blood circulation and removing dampness through diuresis, and decreasing glutamic-pyruvic transaminase, and is applied to active period treatments of acute hepatitis, prolonged hepatitis and chronic hepatitis. Sarmentosin has very strong affinity and aggregation, can have targeted attack, complex treatment of multi-azimuth and multi-level, rapid effect of decreasing serum ALT, and various functions of inhibiting inflammatory cells, swallowing and killing virus cells of liver cells, stimulating principle metabolism and energy metabolism of liver cells while improving the detoxification function of the liver cells, and benefiting the repair of damaged liver cells,, therefore, the capsule has the functions of decreasing enzyme, removing jaundice, protecting liver cells, automatically adjusting organisms, and activating self-immunity, thus the organisms can generate protective antibodies.
Owner:李浪辉
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