1626results about How to "Increase lethality" patented technology

A digital processor aiming and firing system generates a trigger signal with electronic timing exactness, resulting in shooting accuracy unobtainable by humans. To achieve this, a view down the barrel sight is captured by a digital video camera and analyzed on a frame-by-frame basis by an electronic processor equipped with image identification software. Motion detectors attached to the weapon are used to interpolate the barrel position between frames. A motion history of the barrel position relative to the target is calculated and an extrapolation of the future position is made. When the anticipated barrel direction impinges on the target, corrected for motion and ballistic effects, the processor signals the launch of the projectile.

The present invention belongs to the fields of molecular biology and immunology and relates to a chimeric antigen receptor combining EGFR (epidermal growth factor receptor) family proteins and a composition and uses thereof The present invention particularly relates to the chimeric antigen receptor comprising polypeptides efficiently combining the EGFR family proteins and transmembrane domains, wherein the polypeptides efficiently combining EGFR family proteins comprise HERIN. The chimeric antigen receptor can promote the proliferation ability and killing effect of T cell at the premise of maintaining the killing specificity of the T cell.

A foaming insecticidal ant spray is described that minimally comprises an essential oil, an emulsifier, a carboxylate salt and water, which has maximum mortality on ants. A method for killing and controlling ants is described wherein the composition is foamed directly onto the ants whereby the ants become entangled within the foam, increase their contact time with the compositions, and perish.

The invention relates to a method for in-vitro amplification of NK cells, and in particular relates to a method for massive in-vitro amplification of NK cells, wherein the method comprises the following steps of: a, inoculating a peripheral blood mononuclear cell in a CD3McAb and CD226McAb pre-coated culture bottle for coculture; b, adding 1L-2 and 1L-18, coculturing for 72hours to stimulate amplification of NK cells; c, transferring the NK cells, K562 cells after lethal treatment and a serum-free medium containing 1L-2 and 1L-18 in a cell culture bag for coculture; and d, collecting the NK cells. According to the method for in-vitro amplification of the NK cells, two antibodies CD3McAb and CD226McAb are simultaneously coated, so the cell factor synthesis and ADCC effect are promoted, and killing toxicity of the NK cells is remarkably improved; the activation and amplification on the NK cells are achieved just by the 1L-2 and 1L-18 cell factors, so the amplification multiple and cell toxicity of the NK cells are guaranteed, and the cost of cell culture is reduced.

The invention discloses a PD-L1 affinity peptide P1 with anti-tumour activity, which is the polypeptide obtained by phage display peptide library screening, wherein the amino acid sequence thereof is FPNWSLRPMNQM, and the molecular weight thereof is1520.7. The affinity peptide P1 with anti-tumour activity and aiming at a PD-L1 target disclosed by the invention has the advantage of being screened with a high flux by utilizing a phage display peptide library screening technology for the first time; and via an in-vivo tumour-bearing experiment for Kunming mice, the affinity peptide P1 disclosed by the invention is proved to have a great anti-tumour activity, can induce the internal tumour cell apoptosis of mice, and have an extremely high killing capacity for tumour cells. Via the affinity peptide P1 disclosed by the invention, new thoughts and theoretical basis are provided for research and development on medicines based on PD-L1.

The present invention relates to anti-PD1 and anti-CD19 bispecific antibody and applications thereof, wherein the anti-PD1 and anti-CD19 bispecific antibody, or a variant, or a functional fragment thereof comprises: a domain capable of specifically recognizing and binding an immune cell surface antigen PD-1, wherein the domain comprises the heavy chain variable region (anti-PD-1 VH) of an anti-PD-1 specific antibody; and a domain capable of specifically recognizing and binding CD19, wherein the domain comprises the heavy chain variable region (anti-CD19 VH) of an anti-CD19 specific antibody. According to the present invention, the bispecific antibody has the whole human sequence, such that the occurrence of HAMA in clinical treatment application is effectively avoided, the occurrence of drug resistance can be effectively reduced, and the utilization efficiency and the treatment effect of the medicine can be improved; and the anti-PD-1 and anti-CD19 bispecific antibody can well mediate T cells to efficiently and specifically kill B-lymphocyte derived tumor cells compared to the existing anti-PD-1 specific antibody and the existing anti-CD19 specific antibody.

An interleukin-15 (IL-15) gene modified natural killing cell strain for immunotherapy of tumor is prepared through inserting the cDNA coding region of IL-15 in pcDNA3 eucaryotic expression carrier, configuring secretion-type recombinant eucaryotic expression carrier pc DNA3/IL-15, using liposom to transfecte cell NK-92, adding Geneticin (G418) to screening culture medium, screening, limited dilution to cloned cells, detecting activity, choosing positive cell clones, and amplification.

This invention features a kinetic energy rod warhead including a projectile core including a plurality of different size projectiles, an explosive charge about the core, and at least one detonator for the explosive charge.

The invention provides a CD19 targeted CAR (chimeric antigen receptor)-T cell, a preparation method and an application and relates to the field of immune cells. The activation capacity of T cells in CAR-T cell therapy can be improved, the problem of insufficient transfection efficiency can be solved, and the CAR-T cell has a high killing capacity for CD19. The CD19 targeted CAR-T cell expresses a CD19 targeted CAR gene on surface, and the CD19 targeted CAR gene is formed by connecting a single-chain antibody CD19ScFv of CD19, a hinge region and a transmembrane region of CD8, an intracellular signal structure of CD28, an intracellular signal structure of 4-1BB and an intracellular signal structural domain of CD3zeta in series, and the base sequence of the CD19 targeted CAR gene is shown as SEQ ID NO:2.

A method and apparatus using ultrasonic sensors for determination of the pointing vector described by two points separated in space in the coordinate frame of the measuring system. For measurement, acoustic signals are transmitted from two emitters whose spatially separated coordinates form the desired pointing vector. Three detectors, associated receiver electronics and software are required to compute six distinct spheres from the time of flight measurements. The intersection of the three spheres, associated with each emitter, describe the desired location in the detector coordinate system of that emitter. With the coordinates of each emitter, the pointing vector is computed using standard geometry. A reference is required to determine the time of flight of the signals to each detector. Another embodiment uses an active reflective technique, where the timing is obtained through round trip transmission and reception of the signal with a known fixed delay at the vector points.

The invention relates to an anti-dandruff composition and applications thereof, and belongs to the field of daily chemical products. The anti-dandruff composition comprises the following components in parts by weight: 0.3 to 3.6 parts of zinc pyrithione, 0.01 to 3.5 parts of piroctone olamine, 0.05 to 3.8 parts of hexamidine diisethionate, 0.1 to 4.0 parts of DM-846, and 0.5 to 5.0 parts of plant anti-dandruff agent, wherein DM-846 is composed of the following components in percentage by weight: 18 to 20% of dichlorobenzyl alcohol, 5 to 7% of sodium isostearoyl lactylate, 68 to 70% of cocamidopropyl PG-dimethyl ammonium chloride, and 5 to 7% of sodium lactate; and the plant anti-dandruff agent is composed of glycyrrhetinic acid, saponins, an azadirachta indica seed extract, and a solvent. The invention also provides a shampoo containing the anti-dandruff composition. The provided anti-dandruff composition has the advantages that the stimulation to scalp is reduced; at the same time, a good anti-dandruff effect is achieved, multiple anti-dandruff functions are realized, the antibacterial and anti-dandruff effect is good; the antibacterial and anti-dandruff effect of the shampoo is good, and the stability is high.

Provided is a launchable remote-control attack device that enables an operator to remotely grasp the status of a target place and to remotely control weapons it has been equipped with to perform an attack using explosives or gas when necessary. The remote-control attack device includes a cylindrical body with a camera, drivers which are made up of two tires that are disposed on opposite sides of the body and can be driven individually, and battery units for supplying power and which are disposed in central openings of the tires of the drivers. The attack device further includes a plurality of storage units and a wireless control unit.

The invention provides a silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and a preparation method thereof. Low-molecular-weight chitosan is used as a raw material, and a low-molecular-weight chitosan acetic acid solution, a silver nitrate solution and a vanillic aldehyde ethanol solution are mixed to form composite sol; then paraffin is used as a continuous phase, sorbitan monooleate and alkylphenol ethoxylates are used as a compound emulsifier, a silver/low-molecular-weight chitosan sol is used as a monomer, and sodium tripolyphosphate is used as a cross-linking agent for preparing an emulsion system for emulsification crosslinking, and finally washing and drying are performed, so that the silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent is obtained. Due to the fact that the low-molecular-weight chitosan is used as the raw material, nanometer silver particles can enter microspheres, and the antibacterial activity of the composite antibacterial agent is obviously improved. The obtained antibacterial agent has the broad-spectrum bactericidal activity, and has the efficient fatality rate for both escherichia coli and staphylococcus aureus.

A kinetic energy rod warhead including a plurality of sections each enclosing a plurality of projectile and an explosive charge partially surrounding the projectiles defining a primary projectile firing direction. The firing direction of each section is different for isotropically deploying the projectiles.

The invention relates to a disinfectant used in anti-penetrate film and relative preparing method. It is characterized in that: said disinfectant is formed by C4H4CLNOS C4H5NOS, bromine nitrogen isothiazole, bromine nitro compound, solvent and water. In the room temperature that under 50Deg. C, adding deionized water or anti-penetrate water; adding solvent into reaction kettle; adding bromine nitrogen isothiazole to be mixed and dissolved; adding bromine nitro compound; and adding C4H4CLNOS C4H5NOS to be mixed for 20-30mins.