1631results about How to "Increase lethality" patented technology

A digital processor aiming and firing system generates a trigger signal with electronic timing exactness, resulting in shooting accuracy unobtainable by humans. To achieve this, a view down the barrel sight is captured by a digital video camera and analyzed on a frame-by-frame basis by an electronic processor equipped with image identification software. Motion detectors attached to the weapon are used to interpolate the barrel position between frames. A motion history of the barrel position relative to the target is calculated and an extrapolation of the future position is made. When the anticipated barrel direction impinges on the target, corrected for motion and ballistic effects, the processor signals the launch of the projectile.

A buttstock for a firearm having a buffer recoil mechanism is collapsible and adjustable. The buttstock includes a lower receiver extension having a bore therein that fits over the buffer recoil mechanism, the lower receiver extension being fixed to the buffer recoil mechanism; a buttstock body having a bore therein for receiving the lower receiver extension; a locking lever disposed along the bottom edge of the buttstock body; a locking pin disposed in the buttstock body and in the locking lever; and a compression spring disposed around the locking pin for biasing the locking pin towards the lower receiver extension.

The present invention belongs to the fields of molecular biology and immunology and relates to a chimeric antigen receptor combining EGFR (epidermal growth factor receptor) family proteins and a composition and uses thereof The present invention particularly relates to the chimeric antigen receptor comprising polypeptides efficiently combining the EGFR family proteins and transmembrane domains, wherein the polypeptides efficiently combining EGFR family proteins comprise HERIN. The chimeric antigen receptor can promote the proliferation ability and killing effect of T cell at the premise of maintaining the killing specificity of the T cell.

An apparatus for sterilizing or disinfecting fluids, which comprises a fluid conduit, an ultraviolet light source, which is at least partially within the fluid conduit, and an air drive unit coupled to the fluid conduit. The ultraviolet light source generates an ultraviolet light, which kills microorganisms in the fluid, thus sterilizing or disinfecting the fluid. The air dive unit creates air bubbles in the fluid, such as for fish tanks, fish hatchery ponds, or the like. In accordance with one embodiment of the present invention, the ultraviolet light source comprises an ultraviolet light bulb being surrounded by a protective sleeve. The protective sleeve preferably comprises a UV transmissive material, which may comprise a fluoropolymer material, such as PTFE, FEP, PFA, AF and Tefzel ETFE.

A system and method can provide a command and control paradigm for integrating robotic assets into human teams. By integrating sensor to detect human interaction, movement, physiology, and location, a net-centric system can permit command of a robotic platform without an OCU. By eliminating the OCU and maintaining the advantages of a robotic platform, a robot can be used in the place of a human without fatigue, being immune to physiological effects, capable of non-humanoid tactics, a longer potential of hours per day on-station, capable of rapid and structured information transfer, has a personality-free response, can operate in contaminated areas, and is line-replaceable with identical responses. A system for controlling a robotic platform can comprise at least one perceiver for collecting information from a human or the environment; a reasoner for processing the information from the at least one perceiver and providing a directive; and at least one behavior for executing the directive of the reasoner.

This invention discloses a compound antibacterial silk nanometer fibrous material, accounting for weight its component proportion are: Sericin protein 58-90%; chitosan or chitin 0-40%, antibacterial agent 0-5%, electric conduction 1-4%,crossing linking 1-4%. Its process is: dissolve the pure sericin protein, antibiotics separately in polar solvent, join electric conduction medicinal preparation and crosslinking agent, using the static electricity spinning technique, making the average aperture for 0.5-5.0 micron, factor of porosity 60-90%, the mean diameter is 40-100nm and the material is nanometer textile fiber adhesive-bonded membrane. This invention has good organization compatibility with human body, Antibiotics and sericin insoluble is in homogeneous solvent, massive holes among the nanometer textile fiber adhesive-bonded membrane, which has outstanding aqueous percolation permeability, antibacterial agent distributes evenly in the nanometer textile fiber, and the medicine release effect is perfect, so it can be a kind of ideal resist bacteria injured medical material.

The invention relates to a preparation method and application of an autologous CAR (chimeric antigen receptor)-T cell. An established CD28-CD137-CD19-CD3 full-length gene is guided into a T-cell of a patient by a CRISPR / Cas9 technology to prepare the CAR-T cell, and the CAR-T cell is subjected to expansion in vitro and then returns in the body of the patient to perform anti-tumor treatment. Compared with the traditional tumor treatment method, the method has the advantages that the method is cell targeted therapy and small in side effect; the gene modified T cell can stably express an antigen binding domain on the surface and identify a target antigen, and does not have MHC limit; and the tumor treatment effect is improved.

The invention discloses a biopesticide bactericide prepared from Chinese herbs and the use of the biopesticide bactericide. The bactericide is prepared from the following components in percentage by weight: 45%-55% of garlic extract, 15%-25% of heartleaf houttuynia herb extract, 10%-20% of purslane extract, 8%-15% of extract of folium artemisiae argyi, gingko and sweet wormwood, and 3%-5% of sulfur powder. The biopesticide bactericide prepared from Chinese herbs has a strong killing effect on pathogenic bacteria of pythium rot, damping off, rice blast and the like of crops such as rice, wheat and vegetables; the bactericide is capable of achieving the purpose of preventing and treating fungus and bacterial disease, and also capable of promoting the expression of a defensive enzyme system in the bodies of plants, improving the disease resistance of the plants and promoting the increase of production of crops; meanwhile, the prevention and treatment effect of the bactericide on soil-borne diseases propagated via soil is above 90%.

Disclosed is an air purification filter with novel active media that attracts, migrates, binds, and destroys pathogens, including sub-micron pathogens, that are suspended in the air passing through the filter. These properties are incorporated in the micro-fibers comprising the active filter media by several novel methods. One embodiment uses polymers or solgel bound monomers of quaternary ammonium compounds as a biocide with both chemotactic and pathogen membrane lysing properties. Another embodiment uses biocide chemicals blended into the melt before filter fibers are extruded and electret dipole charged. The attracting-binding properties of the embodiments may be enhanced by including electropositive Boehmite nano-fiber strands in the active media, by coating a reversible voltage charged electro-conductive polymer, by the use of supplemental fusing and lysing chemicals, and by optional ion field charging of incoming pathogens.

A foaming insecticidal ant spray is described that minimally comprises an essential oil, an emulsifier, a carboxylate salt and water, which has maximum mortality on ants. A method for killing and controlling ants is described wherein the composition is foamed directly onto the ants whereby the ants become entangled within the foam, increase their contact time with the compositions, and perish.

The invention relates to a method for in-vitro amplification of NK cells, and in particular relates to a method for massive in-vitro amplification of NK cells, wherein the method comprises the following steps of: a, inoculating a peripheral blood mononuclear cell in a CD3McAb and CD226McAb pre-coated culture bottle for coculture; b, adding 1L-2 and 1L-18, coculturing for 72hours to stimulate amplification of NK cells; c, transferring the NK cells, K562 cells after lethal treatment and a serum-free medium containing 1L-2 and 1L-18 in a cell culture bag for coculture; and d, collecting the NK cells. According to the method for in-vitro amplification of the NK cells, two antibodies CD3McAb and CD226McAb are simultaneously coated, so the cell factor synthesis and ADCC effect are promoted, and killing toxicity of the NK cells is remarkably improved; the activation and amplification on the NK cells are achieved just by the 1L-2 and 1L-18 cell factors, so the amplification multiple and cell toxicity of the NK cells are guaranteed, and the cost of cell culture is reduced.

A method for enhancing anticancer capability of CIK cells is provided. The method includes knockout of a PD-1 gene of the CIK cells based on a CRISPR / Cas9 technique. The invention also provides enhanced type CIK cells obtained by the method. Experiments prove that the knockout of the PD-1 gene from the CIK cells can effectively enhance anti-hepatoma capability of the CIK cells, thus providing novel effector cells for tumor cellular immunotherapy.

The invention discloses a PD-L1 affinity peptide P1 with anti-tumour activity, which is the polypeptide obtained by phage display peptide library screening, wherein the amino acid sequence thereof is FPNWSLRPMNQM, and the molecular weight thereof is1520.7. The affinity peptide P1 with anti-tumour activity and aiming at a PD-L1 target disclosed by the invention has the advantage of being screened with a high flux by utilizing a phage display peptide library screening technology for the first time; and via an in-vivo tumour-bearing experiment for Kunming mice, the affinity peptide P1 disclosed by the invention is proved to have a great anti-tumour activity, can induce the internal tumour cell apoptosis of mice, and have an extremely high killing capacity for tumour cells. Via the affinity peptide P1 disclosed by the invention, new thoughts and theoretical basis are provided for research and development on medicines based on PD-L1.

The invention discloses a homogeneous material-containing corundum-mullite high-strength abrasion-resisting plastic, belonging to the field of high-temperature abrasion-resisting fireproofing material, comprising high-aluminum homogeneous material, alumina fine powder, silica fine powder, clay, phosphoric acid, aluminum dihydrogen phosphate solution, pure calcium aluminate cement and the like as raw materials, wherein the homogeneous material is as follows: the content of Al2O3 is 70-90% and the volume density is 2.9-3.5g.cm<-3>. Synthetic homogeneous material with low water-absorption, low porosity and high homogeneity is used for substituting the traditional natural raw material of sintered alumina clinker with high-absorption, high porosity and low homogeneity or composite raw material system of corundum and mullite to produce homogeneous corundum-mullite high-strength abrasion-resisting plastic. Distinguished from the castable, the plastic can be directly utilized in the construction method of smearing and ramming without supporting a module. The material of the invention is good in workability, high in strength, good in abrasive resistance and optimal in on-site usage effect, which is in favour of prolonging service life of furnace lining and improving utilization efficiency of the high-temperature furnace.

The present invention relates to anti-PD1 and anti-CD19 bispecific antibody and applications thereof, wherein the anti-PD1 and anti-CD19 bispecific antibody, or a variant, or a functional fragment thereof comprises: a domain capable of specifically recognizing and binding an immune cell surface antigen PD-1, wherein the domain comprises the heavy chain variable region (anti-PD-1 VH) of an anti-PD-1 specific antibody; and a domain capable of specifically recognizing and binding CD19, wherein the domain comprises the heavy chain variable region (anti-CD19 VH) of an anti-CD19 specific antibody. According to the present invention, the bispecific antibody has the whole human sequence, such that the occurrence of HAMA in clinical treatment application is effectively avoided, the occurrence of drug resistance can be effectively reduced, and the utilization efficiency and the treatment effect of the medicine can be improved; and the anti-PD-1 and anti-CD19 bispecific antibody can well mediate T cells to efficiently and specifically kill B-lymphocyte derived tumor cells compared to the existing anti-PD-1 specific antibody and the existing anti-CD19 specific antibody.

The invention discloses a method for amplification and activation of NK cells by K562 cells. The method comprises that through synergism of K562 cells transfected by transmembrane interleukin 21, CD14, CD19, CD86 and CD137, and low-concentration interleukin 2, NK cells are subjected to directed amplification and activation. Compared with the existing similar compounds, the compound provided by the invention has a stronger lymphocyte amplification and activation capability and higher efficiency. The method has wide prospects in immunological therapy.

An interleukin-15 (IL-15) gene modified natural killing cell strain for immunotherapy of tumor is prepared through inserting the cDNA coding region of IL-15 in pcDNA3 eucaryotic expression carrier, configuring secretion-type recombinant eucaryotic expression carrier pc DNA3 / IL-15, using liposom to transfecte cell NK-92, adding Geneticin (G418) to screening culture medium, screening, limited dilution to cloned cells, detecting activity, choosing positive cell clones, and amplification.

This invention features a kinetic energy rod warhead including a projectile core including a plurality of different size projectiles, an explosive charge about the core, and at least one detonator for the explosive charge.

The invention provides a CD19 targeted CAR (chimeric antigen receptor)-T cell, a preparation method and an application and relates to the field of immune cells. The activation capacity of T cells in CAR-T cell therapy can be improved, the problem of insufficient transfection efficiency can be solved, and the CAR-T cell has a high killing capacity for CD19. The CD19 targeted CAR-T cell expresses a CD19 targeted CAR gene on surface, and the CD19 targeted CAR gene is formed by connecting a single-chain antibody CD19ScFv of CD19, a hinge region and a transmembrane region of CD8, an intracellular signal structure of CD28, an intracellular signal structure of 4-1BB and an intracellular signal structural domain of CD3zeta in series, and the base sequence of the CD19 targeted CAR gene is shown as SEQ ID NO:2.

An improved light gas gun launches a projectile in a light gas atmosphere as it travels through a frictionless barrel to achieve high muzzle velocities, decreased acoustic signatures, and increased ranges. The light gas atmosphere is introduced by a purge valve prior to firing or by a muzzle valve that holds a positive light gas pressure on the barrel and breech. The muzzle valve also routes the majority of propellant gases through a suppression canister, reducing the light gas gun's acoustic signature. The frictionless barrel uses light gas propellant routed through gas bearings to keep the projectile centered in the barrel and preclude the projectile from contacting the barrel walls, eliminating barrel wear. The system includes a projectile assembly that stores light gas from the firing and injects it into the boundary layer, reducing drag, increasing range and lethality, and decreasing acoustic signature of the projectile down range.

A method and apparatus using ultrasonic sensors for determination of the pointing vector described by two points separated in space in the coordinate frame of the measuring system. For measurement, acoustic signals are transmitted from two emitters whose spatially separated coordinates form the desired pointing vector. Three detectors, associated receiver electronics and software are required to compute six distinct spheres from the time of flight measurements. The intersection of the three spheres, associated with each emitter, describe the desired location in the detector coordinate system of that emitter. With the coordinates of each emitter, the pointing vector is computed using standard geometry. A reference is required to determine the time of flight of the signals to each detector. Another embodiment uses an active reflective technique, where the timing is obtained through round trip transmission and reception of the signal with a known fixed delay at the vector points.

The invention relates to an anti-dandruff composition and applications thereof, and belongs to the field of daily chemical products. The anti-dandruff composition comprises the following components in parts by weight: 0.3 to 3.6 parts of zinc pyrithione, 0.01 to 3.5 parts of piroctone olamine, 0.05 to 3.8 parts of hexamidine diisethionate, 0.1 to 4.0 parts of DM-846, and 0.5 to 5.0 parts of plant anti-dandruff agent, wherein DM-846 is composed of the following components in percentage by weight: 18 to 20% of dichlorobenzyl alcohol, 5 to 7% of sodium isostearoyl lactylate, 68 to 70% of cocamidopropyl PG-dimethyl ammonium chloride, and 5 to 7% of sodium lactate; and the plant anti-dandruff agent is composed of glycyrrhetinic acid, saponins, an azadirachta indica seed extract, and a solvent. The invention also provides a shampoo containing the anti-dandruff composition. The provided anti-dandruff composition has the advantages that the stimulation to scalp is reduced; at the same time, a good anti-dandruff effect is achieved, multiple anti-dandruff functions are realized, the antibacterial and anti-dandruff effect is good; the antibacterial and anti-dandruff effect of the shampoo is good, and the stability is high.

A weapon system comprises a first, second and third sensor and a range detecting means. The weapon system further comprises a weapons platform removably mounted to a moveable vehicle. The weapons platform includes a gun. The first sensor is mechanically attached to the gun for sensing an image. The second sensor senses a position of the gun, including at least an elevation and azimuth. The third sensor detects a rate and altitude of the moveable vehicle. The range detecting means detects a range of the gun to the target. The weapon system also comprises an image processor for processing the image from the first sensor, a display for displaying the processed image and a controller. The controller calculates an expected impact point for a round of fire based upon the sensed and detected data, and superimposes the expected impact point on the processed image on the display.

Provided is a launchable remote-control attack device that enables an operator to remotely grasp the status of a target place and to remotely control weapons it has been equipped with to perform an attack using explosives or gas when necessary. The remote-control attack device includes a cylindrical body with a camera, drivers which are made up of two tires that are disposed on opposite sides of the body and can be driven individually, and battery units for supplying power and which are disposed in central openings of the tires of the drivers. The attack device further includes a plurality of storage units and a wireless control unit.

The invention provides a silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and a preparation method thereof. Low-molecular-weight chitosan is used as a raw material, and a low-molecular-weight chitosan acetic acid solution, a silver nitrate solution and a vanillic aldehyde ethanol solution are mixed to form composite sol; then paraffin is used as a continuous phase, sorbitan monooleate and alkylphenol ethoxylates are used as a compound emulsifier, a silver / low-molecular-weight chitosan sol is used as a monomer, and sodium tripolyphosphate is used as a cross-linking agent for preparing an emulsion system for emulsification crosslinking, and finally washing and drying are performed, so that the silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent is obtained. Due to the fact that the low-molecular-weight chitosan is used as the raw material, nanometer silver particles can enter microspheres, and the antibacterial activity of the composite antibacterial agent is obviously improved. The obtained antibacterial agent has the broad-spectrum bactericidal activity, and has the efficient fatality rate for both escherichia coli and staphylococcus aureus.

A system and method can provide a command and control paradigm for integrating robotic assets into human teams. By integrating sensor to detect human interaction, movement, physiology, and location, a net-centric system can permit command of a robotic platform without an OCU. By eliminating the OCU and maintaining the advantages of a robotic platform, a robot can be used in the place of a human without fatigue, being immune to physiological effects, capable of non-humanoid tactics, a longer potential of hours per day on-station, capable of rapid and structured information transfer, has a personality-free response, can operate in contaminated areas, and is line-replaceable with identical responses. A system for controlling a robotic platform can comprise at least one perceiver for collecting information from a human or the environment; a reasoner for processing the information from the at least one perceiver and providing a directive; and at least one behavior for executing the directive of the reasoner.

A kinetic energy rod warhead including a plurality of sections each enclosing a plurality of projectile and an explosive charge partially surrounding the projectiles defining a primary projectile firing direction. The firing direction of each section is different for isotropically deploying the projectiles.

The invention discloses an in-vitro large-scale amplification method of natural killer cells. The method comprises the following steps: collecting and separating peripheral blood mononuclear cells; sorting natural killer cells; culturing the natural killer cells; and collecting the natural killer cells. The method utilizing immunomagnetic beads to sort the natural killer cells has the advantages of simplicity in establishing and operation, and high comprehensive efficiency; and the effect of the method adopting in-vitro amplification of the immunomagnetic bead shorted NK cells is 2-3 times the effect of present amplification methods, so the method disclosed in the invention has great application values in the field of in-vitro large-scale amplification.

The invention relates to a disinfectant used in anti-penetrate film and relative preparing method. It is characterized in that: said disinfectant is formed by C4H4CLNOS C4H5NOS, bromine nitrogen isothiazole, bromine nitro compound, solvent and water. In the room temperature that under 50Deg. C, adding deionized water or anti-penetrate water; adding solvent into reaction kettle; adding bromine nitrogen isothiazole to be mixed and dissolved; adding bromine nitro compound; and adding C4H4CLNOS C4H5NOS to be mixed for 20-30mins.