297 results about "Indole Compound" patented technology

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The invention belongs to the field of organic synthetic chemistry, and relates to a preparation method of melatonin and meerythrine indole derivatives and compounds. Specifically, the indole derivative is efficiently synthesized by taking arylamine and carboxylic acid as raw materials through a one-pot two-step reaction in the presence of catalysis of ferric chloride hexahydrate (FeCl3. 6H2O), a ligand, a diazotization reagent, an additive and a solvent under the conditions of visible light irradiation, inert atmosphere and room temperature. According to the method, visible light induced iron-based LMCT catalysis and iron lewis acid catalysis functions are integrated, and efficient integration of diazotization, decarboxylation, free radical coupling and cyclization reaction is achieved. The method has the advantages that raw materials are cheap and easy to obtain, reaction conditions are mild, substrate applicability is wide, functional group compatibility is good, operation is easy, convenient and safe, and environment friendliness is achieved, gram-level scale preparation can be achieved, and a green and efficient synthesis path is provided for indole compounds with biological activity such as melatonin and meerythrine.

Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

The invention discloses a preparation method of a 3-thiocyano indole derivative. According to the method, indole or substituted indole is taken as a substrate, ammonium thiocyanate is taken as a reactant, N-fluorobenzenesulfonamide (NFSI) is taken as an accelerant, reaction is carried out for 0.5-3 hours at room temperature, and C3-thiocyanated indole can be obtained. The method has the advantages of easily available reaction raw materials, mild reaction conditions and short reaction time, is suitable for industrial production, and provides a new method and different reaction mechanisms for thiocyanation of the C3 site of the indole compound.

The invention relates to the technical field of 2-arylindole compounds, in particular to a green method for synthesizing a 2-arylindole compound through catalyst-free light driving. In the prior art, the conventional synthesis method of the 2-aryl indole compound has harsh reaction conditions, and generally, an expensive transition metal catalyst is also required to be added as a catalyst. In order to solve the technical problems, the invention provides the green catalyst-free light-driven synthesis method of the 2-arylindole compound, which comprises the following steps: by taking an indole compound and a diaryl iodonium salt compound as initial reaction raw materials, carrying out blue light irradiation reaction in a reaction solvent at room temperature, and after the reaction is finished, obtaining the 2-arylindole compound. According to the method, reaction raw materials are easy to obtain, reaction steps are simple, conditions are mild, the method is environmentally friendly, no catalyst or chemical additive needs to be added in the reaction process, and the method has good application prospects.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The present invention relates to the field of catalysts, and discloses an indole synthesis catalyst and a preparation method thereof, and an indole compound synthesis method, the indole synthesis catalyst comprises: (1) impregnating a silicon dioxide carrier by using a solution containing a zinc precursor, and carrying out first drying and first roasting to obtain a modified carrier; (2) mixing a first slurry containing the modified carrier with a second solution containing a precursor of the first active component to obtain a mixed solution; (3) contacting the mixed solution with a precipitant, controlling the pH value to be 8-10, carrying out precipitation reaction, and then carrying out aging, secondary drying and secondary roasting; and (4) mixing the product obtained in the step (3), a soluble compound of a second active component, an optional binder and an optional peptizing agent, and carrying out molding, third drying and third roasting. The catalyst prepared by the method has high catalytic activity and good stability.

The application relates to the field of agricultural disease control technology, and particularly relates to the use of indole compounds and pharmaceutically acceptable salts, solvates, crystal forms, prodrugs, stereoisomers and tautomers thereof for preparing a medicine for inhibiting pathogenic key protein kinase CgSlt2 of pathogenic fungi. The application first proposes a new type of CgSlt2-targeted inhibitor, specifically, indole compounds ((S)-N-(1-(1H-indol-3-yl)-4-(methylamino)-4-oxobutan-2-yl)-8-bromo-1,6-naphthyridine-2-carboxamide) and ((S)-N-(2-((1H-indol-3-yl)-1-(methylamino)-1-oxopropyl)-8-bromo-1,6-naphthyridine-2-carboxamide) are used as CgSlt2 inhibitors, have the characteristics of high target specificity and high activity, and exhibit excellent pathogenicity inhibition of a strain of the complex group of Colletotrichum gloeosporioides.

The invention belongs to the technical field of organic synthesis, and discloses a preparation method of a 3-alkylindole compound, which comprises the following steps: in an inert atmosphere, reacting a reaction solution mixed with an indole compound, an allyl alcohol compound, a catalyst Mn-1 and alkali at 110-150 DEG C for 12-24 hours to obtain the 3-alkylindole compound. Mn (CO) 5Br is used as a transition metal and complexed with a PNP pincerlike manganese complex to obtain the Mn-1 catalyst, the 3-alkylindole compound is obtained under the catalysis of the catalyst, allyl alcohol can be aryl allyl alcohol or aliphatic allyl alcohol, a substituent group on an indole ring can be an electron withdrawing group, the application range of a substrate is wide, meanwhile, the selection range of alkali or a solvent is wide, and the 3-alkylindole compound is suitable for industrial production. The method has the advantages of high atom economy, environment friendliness, high safety and the like.

The application belongs to the field of organic synthesis and particularly relates to a synthesis method of polysubstituted indole propionate derivatives. Aryl acetate compounds and sulfonyl indole compounds are used as raw materials, and the reaction is carried out through an isothiourea organic small molecule catalyst. The reaction raw materials are simple and easy to obtain, the reaction conditions are mild, the operation is simple, the reaction time is short, the reaction has good diastereoselectivity and high yield, the synthesis method of the polysubstituted indole propionate derivatives overcomes the defects and deficiencies of the existing synthesis method, and has the characteristics of high efficiency, simplicity and wide universality.

The application discloses an indole compound, a preparation method and application thereof. Specifically, the application provides a compound as shown in formula I, a pharmaceutically acceptable salt or an enantiomer thereof, and the compound can effectively shorten sleep latency, prolong sleep time, and has a better sleep promoting effect.

Some aspects of the disclosure relate to compositions comprising fermentates of bacterial strains capable of producing indole-containing compounds such as ILA and lAld. Some aspects relate to nutritional supplements, and food products containing such fermentates, and methods of use thereof.

The invention provides an indole compound and a solar cell. The indole compound has a structural formula as shown in a formula (I). At least one of R1-R7 has a structure as shown in a formula (Hy1): L1 is any one of substituted or unsubstituted C6-C30 arylene, substituted or unsubstituted C3-C30 heteroarylene, substituted or unsubstituted C1-C30 alkylene, substituted or unsubstituted C1-C30 alkyleneoxy and substituted or unsubstituted C1-C30 alkylenesulfenyl, and R8 is any one of a phosphate group, a carboxylic acid group and a sulfonic acid group; when R1-R7 do not represent the structure represented by formula (Hy1), R1-R7 represent the structure represented by formula (Hy1); a substituted or unsubstituted C1-C30 alkyl group, a substituted or unsubstituted C1-C30 alkoxy group, a substituted or unsubstituted C1-C30 alkylthio group, a substituted or unsubstituted C6-C30 aryl group, a substituted or unsubstituted C6-C30 arylamino group, a substituted or unsubstituted C3-C30 heteroaryl group, a substituted or unsubstituted C3-C30 heteroarylamino group, a substituted or unsubstituted C3-, each independently selected from hydrogen, halogen, nitro, hydroxyl, substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C1-C30 alkoxy group, substituted or unsubstituted C1-C30 alkylthio group, substituted or unsubstituted C6-C30 aryl group, substituted or unsubstituted C3-C30 heteroarylamino group, substituted or unsubstituted C3- and C12 cycloalkyl is selected from any one of C12 cycloalkyl.

Disclosed are substituted indole compounds and compositions. The substituted indole compounds and compositions can be used for treating or preventing acute renal failure in a subject. The compounds and compositions can also be used for treating an infectious disease or cancer.

The invention discloses an indole compound with an effect of treating idiopathic pulmonary fibrosis as well as a preparation method and application of the indole compound, belongs to the field of medicinal chemistry, and particularly relates to an indole compound shown in a general formula I or pharmaceutically acceptable salt of the indole compound and application of the indole compound serving as an HDAC6 inhibitor in the aspect of resisting idiopathic pulmonary fibrosis. The invention also relates to a pharmaceutical composition taking the indole compound or the pharmaceutically acceptable salt thereof as an active ingredient. The invention also relates to an administration dosage form of the compound containing at least one compound or salt thereof, wherein the dosage form is selected from one or more of the following dosage forms: tablets, capsules, injections, suppositories, patches, inhalable powder preparations, suspensions, emulsions or ointments. The invention provides a new thought for exploring medicines capable of effectively treating idiopathic pulmonary fibrosis, and has important clinical significance. # imgabs0 #

The application discloses an iridium complex, a preparation method thereof and application of the iridium complex in synthesis of chiral piperidines, and the preparation method of the iridium complex comprises the following steps: adding an indole compound, an iridium compound and an alkali into a first solvent, heating and stirring at 40-80 DEG C, lowering to room temperature after reaction, filtering, reducing pressure distillation, and separating by silica gel column chromatography to obtain the iridium complex; under the cooperation of the iridium complex as a catalyst and chiral phosphoric acid, 1,5-diol compounds and amine compounds can be directly reacted to obtain a series of chiral piperidine compounds, the method has the advantages of high reaction efficiency, simplicity and high yield, and the enantiomeric excess value of the chiral piperidine prepared by using the iridium catalyst is not less than 83%.

The invention belongs to the technical field of biological medicines, and discloses a carbazole / benzo [cd] indole compound as well as a preparation method and application thereof. The carbazole / benzo [cd] indole compound has a structure as shown in a general formula I: # imgabs0 #, wherein R is one of NO2, NH2, Br and N (Ph) 2. The carbazole / benzo [cd] indole compound can generate active oxygen molecules after illumination, including superoxide anions and hydroxyl radicals, and can be applied to preparation of drugs for photodynamic therapy.

Disclosed herein are solid forms (e.g., crystalline forms) of 4-(5-cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-9H-pyrido[2,3-b]indole (Compound 1), as well as compositions, pharmaceutical compositions, kits, methods, and uses thereof. The compounds disclosed herein are inhibitors of atypical protein kinase C (aPKC), and therefore, their solid forms are useful for treating and / or preventing basal cell carcinoma.

The invention belongs to the field of chemical synthesis, and particularly relates to a method for catalytically synthesizing quaternary carbon indole compounds by DMAP. Specifically, in the presence of a catalyst DMAP, no transition metal catalyst or ligand is added, the 2-indolinone derivative shown in the formula C: # imgabs0 # is prepared from a compound shown in the formula A and a compound shown in the formula B, and the 2-indolinone derivative shown in the formula C: # imgabs0 # is obtained with good selectivity and yield, and R is phenyl or methyl.

This invention relates to the pharmaceutical field, specifically to a heteroindole derivative, its synthesis method, and its applications. The heteroindole compound derivative has the structure shown in general formula (I), wherein R1 is selected from any one of N-Boc-trans-1,4-cyclohexanediamine, N-Boc-piperazinyl, trans-1,4-cyclohexanediamine, piperazinyl, and N-methylpiperazinyl; R2 is selected from H or a halogen atom; and X, Y, and Z are all selected from CH or N. This invention demonstrates through experiments that the heteroindole derivative possesses good CDK9 inhibitory activity and selectivity, providing a theoretical basis for the treatment of diseases related to the activity or expression level of the cell cycle-dependent kinase CDK9, and exhibits good pharmaceutical potential.

The present invention discloses a method for synthesizing indoline, which is characterized in that: under the co-catalysis of yttrium bis(trimethylsilylamide) and tris(pentafluorophenyl)borane, an additive, a hydrogen source, and an indole compound are used as raw materials to react in a solvent to obtain an indoline compound; the structural formula of the indole compound is the structural formula of the indoline compound. The raw materials of the method of the present invention are widely sourced or easy to prepare, with simple operation, controllable selectivity, high yield, mild conditions, and wide generality.

The invention relates to an azaindole compound as well as a preparation method and application thereof. The compound has a structure as shown in a formula I. The invention also relates to a preparation method of the compound with the structure shown in the formula I and a pharmaceutical composition. The invention also provides application of the compound in preparation of drugs for reducing uric acid.