This invention relates to the field of
medicinal chemistry, specifically disclosing a
triazole-fused piperidinone derivative, its preparation method, and its application. The
triazole-fused piperidinone derivative has the structure shown in Formula I; wherein, R... 1 Selected from
alkyl, phenyl, substituted phenyl, naphthyl ring,
furan ring,
thiophene ring, or
pyridine ring; R 2 Selected from
alkyl, allyl, or benzyl; R 3 The derivatives are selected from
alkyl, phenyl, substituted phenyl, acyl, or
sulfonyl groups. Studies have shown that the
triazole-fused piperidinone derivatives described herein possess certain antiviral activity. Furthermore, the preparation method described in this invention can be carried out under mild conditions, is simple to operate, involves few steps, has good functional group compatibility, and yields high results. Therefore, this method has promising application prospects in pharmaceutical industrial production.