100 results about "Phenyl-naphthylene" patented technology

The invention belongs to the technical field of lithium-sulfur batteries, and particularly relates to a polyurethane-based polymer, a preparation method and application thereof, an electrode binder and a lithium-sulfur battery positive electrode material. The polyurethane-based polymer provided by the invention has a structure as shown in a formula I; in the formula I, R1 comprises alkylene, substituted alkylene, phenyl, substituted phenyl, naphthyl or substituted naphthyl; r2 comprises an ether group, an alkenyl group, an ester group, a phenolic group, an aldehyde group, a wood fiber group or a glycosyl group. The polyurethane-based conductive polymer provided by the invention has abundant chemical adsorption sites, a hydrogen bond network can be formed among molecules, and soluble lithium polysulfide can be effectively anchored and limited on one side of a positive electrode when the polyurethane-based conductive polymer is used as a positive electrode binder, so that the purposes of inhibiting a shuttle effect, stabilizing the battery capacity and improving the cycle performance are achieved. In addition, the polyurethane-based conductive polymer can greatly eliminate the insulativity of a sulfur positive electrode, promote rapid transmission of lithium ions and electrons and improve the specific discharge capacity. # imgabs0 #

The invention relates to the technical field of insulating oil, and particularly discloses antioxidant insulating oil as well as a preparation method and application thereof. The antioxidant insulating oil provided by the invention comprises synthetic oil, a composite antioxidant and a pour point depressant, the composite antioxidant is prepared from the following components in parts by weight according to the weight of the composite antioxidant: 15 to 25 parts of N-phenyl-1-naphthylamine, 25 to 40 parts of antioxidant 5057, 15 to 25 parts of 3-diisobutoxy thiophosphoryl thio-2-methyl-propionic acid and 10 to 15 parts of tetraethylene glycol dimethyl ether trihydrate; the invention also provides a preparation method of the antioxidant insulating oil. The antioxidant insulating oil provided by the invention not only has good insulativity and heat dissipation performance, but also has excellent oxidation resistance, and can meet the use requirements in a long-time high-temperature electric field environment when being used for a motor of an electric motorcycle.

This invention discloses a cellulose acetate-based 1,8-naphthalenedimide fluorescent probe for detecting hydrazine, its preparation method, and its application. The invention uses 4-bromo-1,8-naphthalenedimide as a raw material, which undergoes a condensation reaction with 4-aminobutyric acid to obtain 4-(4-bromo-1,8-naphthalenedimide)butyric acid (BNA-B); BNA-B undergoes a coupling reaction with 4-formylphenylboronic acid to obtain 4-(4-(4-formylphenyl)-1,8-naphthalenedimide)butyric acid (FNA-B); compound FNA-B then undergoes an esterification reaction with cellulose acetate (CA) to obtain the cellulose acetate-based 1,8-naphthalenedimide fluorescent probe FNA-B-CA. This compound specifically recognizes hydrazine. Under 365 nm ultraviolet light irradiation, the addition of hydrazine to a DMF / H2O solution of FNA-B-CA changes the fluorescence color of the solution from bright blue to colorless, indicating a detection limit of 8.4 × 10⁻⁶ for hydrazine. ‑8 M has promising applications as a fluorescent probe for the detection of hydrazine.

The invention discloses a cellulose acetate based 1, 8-naphthalimide fluorescent probe for detecting hydrazine as well as a preparation method and application of the cellulose acetate based 1, 8-naphthalimide fluorescent probe. The preparation method comprises the following steps: by taking 4-bromo-1, 8-naphthalic anhydride as a raw material, carrying out condensation reaction on the 4-bromo-1, 8-naphthalic anhydride and 4-aminobutyric acid to prepare 4-(4-bromo-1, 8-naphthalic diimide) butyric acid (BNA-B); the preparation method comprises the following steps: carrying out a coupling reaction on BNA-B and 4-formyl phenylboronic acid to prepare 4-(4-(4-formyl phenyl)-1, 8-naphthalimidoyl) butyric acid (FNA-B); and the compound FNA-B and cellulose acetate (CA) are subjected to an esterification reaction, such that the cellulose acetate-based 1, 8-naphthalimide fluorescent probe FNA-B-CA is prepared. The compound can specifically recognize hydrazine, after hydrazine is added into a DMF / H2O solution of FNA-B-CA under the irradiation of 365nm ultraviolet light, the fluorescence color of the solution is changed from bright blue to colorless, the detection limit of hydrazine reaches 8.4 * 10 <-8 > M, and the compound has a good application prospect as a fluorescent probe for detecting hydrazine.

The invention discloses a natural ester insulating oil bifunctional antioxidant as well as preparation and application thereof, and relates to the technical field of insulating oil. According to the bifunctional antioxidant, hydroxyl (-OH) and tert-butyl (-C (CH3) 3) are introduced on the basis of an N-phenyl-alpha-naphthylamine molecular structure, when the bifunctional antioxidant is added into natural ester insulating oil, the tert-butyl can effectively capture free radicals in the molecular structure, the hydroxyl improves the free radical scavenging efficiency, and the antioxidant effect is further improved; hydroxyl can also effectively absorb high-energy ultraviolet light, the lightning impulse resistance of the insulating oil is enhanced, the oxidation resistance of the insulating oil is improved, meanwhile, the lightning impulse resistance of the insulating oil is improved, a synergistic gain effect is achieved, the service life of the insulating oil is jointly prolonged, and the operation safety of electrical equipment is improved.

The application provides a preparation method of a dihydroquinazoline compound and belongs to the technical field of organic synthesis. 1 comprises hydrogen, methyl, tert-butyl, methoxy or halogen; R 2 comprises phenyl; R 3 comprises phenyl; R 4 comprises phenyl, p-tolyl, p-methoxyphenyl, o-tolyl, p-fluorophenyl, p-chlorophenyl, naphthyl, pyridyl or thienyl; Ar comprises phenyl, naphthyl or pyridyl; R 5 comprises phenyl, cyclopropyl, cyclohexyl or [1,1'-biphenyl]-4-yl. The preparation method provided by the application has the advantages of short reaction route, no need to add a transition metal catalyst, good functional group compatibility, high yield, high production efficiency and green environmental protection.

The present invention belongs to the field of organic chemical ligands and discloses a nitrogen-nitrogen-phosphorus ligand having a structure of the general formula I or its tautomers, enantiomers, and diastereomers: #imgabs0#R 1 、R 5 R is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, hydroxyl, aldehyde, carboxyl, ester, halogen, trifluoromethyl, cyano, acyl, amide, amino, nitro, phenyl, benzyl, sulfonyl, sulfonic acid, and mercapto; 2 is selected from one of the following structures: alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, phenyl, benzyl, phenethyl, naphthylmethyl, -CHPh2, ester, -CH2OBn, or substituted phenyl or benzyl, or R 2 With R 4 connected to form a five-membered ring and an acene ring; the R 3 is selected from hydrogen or alkyl; said R 4 is selected from hydrogen, alkyl, alkoxy, alkenyl, alkynyl, phenyl, benzyl; W is PR2 or P(O)R2, and R is selected from phenyl, naphthyl, cyclohexyl, and substituted phenyl. The present invention also discloses a preparation method and use of nitrogen-nitrogen-phosphorus ligands.

The invention relates to the field of lubricating oil, in particular to a compressor oil composition which is prepared from the following components in parts by weight: 0.005 to 0.2 part of an anti-rust agent, 0.05 to 1 part of an extreme pressure anti-wear agent, 0.01 to 0.5 part of a friction reducing agent, 3 to 8 parts of synthetic ester, 0.01 to 1 part of an antioxidant, 0.001 to 0.1 part of an anti-foaming agent and 90 to 97 parts of base oil. The anti-friction agent is a trimethylolpropane-triacid ester derivative, the anti-rust agent is formed by mixing an alkenyl succinic acid half-ester derivative and a carboxyl imidazoline derivative, and the anti-wear reagent at extreme pressure is formed by mixing triphenyl phosphate and an alkyl thiophosphate derivative. The antioxidant is formed by mixing any two of alkyl diphenylamine, alkyl phenyl-alpha-naphthylamine and alkyl hindered phenol. The invention further relates to a preparation method of the compressor oil composition. The compressor oil composition provided by the invention has excellent washing resistance and rust resistance.

The invention relates to a synthesis method of polysubstituted pyrrolidone. The method is characterized in that # imgabs0 # R1 is alkyl-substituted phenyl, trifluoromethyl-substituted phenyl, cyano-substituted phenyl, methylthio-substituted phenyl, dimethylamino-substituted phenyl, alkenyl-substituted phenyl, alkynyl-substituted phenyl, naphthyl, benzothienyl, cyclohexyl, benzyl and indolyl, R2 is long-chain alkyl and phenyl, R3 and R4 are cyano and ester groups, and R3 and R4 can be the same or different. According to the method, azide and vinyl cyclopropane which are different in substitution are taken as raw materials, palladium and phosphine are taken as a catalytic system, the polysubstituted pyrrolidone compound is synthesized by taking carbon dioxide as a raw material, and the yield of a target product is as high as 90%. The palladium and the phosphine which are cheap and easy to obtain are used, and the catalyst cost is low. The nitrine substrate used in the method is easy to prepare, does not have explosiveness, is wide in application range, effectively realizes high-value utilization of carbon dioxide, and meets the requirements of green chemistry.

A triazine compound, a material for organic electroluminescent elements, an electron transport material for organic electroluminescent elements, and an organic electroluminescent element. The purpose of the present invention is to provide a triazine compound which contributes to the production of an organic electroluminescent element having excellent driving voltage and durability. A triazine compound represented by formula (1). In formula (1), A and B each represents an aryl group having 6-20 carbon atoms. L represents a phenyl group or a naphthyl group. And n is 0 or 1. And C represents any one group selected from the group consisting of X, Y, and Z. And Ar1 and Ar2 each represents an aromatic hydrocarbon group or a pyridyl group.

The invention discloses an ashless antioxidant composition applicable to an ultrahigh-temperature lubricating environment, lubricating oil and application of the ashless antioxidant composition. The ashless antioxidant composition is prepared from the following components in parts by mass: 2.5 to 5 parts of dialkyl diphenylamine, 2.5 to 7.5 parts of N-phenyl-alpha-naphthylamine, 0 to 2.5 parts of phenolic antioxidant and 0 to 2.5 parts of amine antioxidant. The ashless antioxidant composition does not contain metal elements, is an ashless antioxidant system, has a good antioxidant effect, can effectively control the viscosity change and acid value increase of an oil product in an ultrahigh-temperature environment of 220-300 DEG C, has an obvious inhibition effect on the generation of high-temperature sediments, and can meet the requirement of an aero-engine on the antioxidant performance of lubricating oil in the ultrahigh-temperature environment.

This invention discloses a phenylnaphthic acid derivative and its application in phosphorescent information encryption. The preparation method involves using 3,5-bis(ethoxycarbonyl)phenylboronic acid and methyl 6-bromo-2-naphthylcarboxylate as raw materials, and then performing a Suzuki coupling reaction under tetra(triphenylphosphine)palladium(O) catalysis to obtain the intermediate ethyl 2-(3,5-bis(ethoxycarbonyl)phenyl)-6-naphthylcarboxylate. This intermediate is then subjected to alkaline hydrolysis and acidification to obtain the target product, 2-(3,5-dicarboxyphenyl)-6-naphthylcarboxylic acid. This phosphorescent material has a simple preparation method, lower cost compared to noble metal phosphorescence systems, a simple guest synthesis method with high yield, and exhibits significant and stable phosphorescence effects. Furthermore, precise emission color control of high-performance doped thin films is achieved through the triplet-to-singlet Förster fluorescence resonance energy transfer (TS-FRET) mechanism, establishing a multicolor long-lifetime emission system. In addition, the material has multi-color adjustable properties and excellent long afterglow emission performance, showing great application potential in cutting-edge application fields such as multi-dimensional information encryption and high-end anti-counterfeiting.

The purpose is to provide a curable resin composition capable of obtaining a cured product having excellent productivity (UV curability) in addition to low absorption (low optical absorption loss) in the near infrared region used in optical communications and excellent heat resistance. A curable resin composition according to the present invention is characterized by having as essential components (A) a polysiloxane resin having one or more reactive groups selected from the group consisting of (meth)acryloyl groups and styryl groups, (B) one or more (meth)acrylic acid derivatives selected from the group consisting of compounds containing a structure represented by general formula (1), and (C) a radical polymerization initiator. (In general formula (1), R1 and R2 each independently represents a hydrogen atom, a methyl group, a phenyl group, a naphthyl group, or a trifluoromethyl group, or represents a cyclohexyl group or a fluorenyl group to which R1 and R2 are bonded.)

The invention belongs to the technical field of biological medicines, and relates to phenyl naphthalene derivatives and application thereof in preparation of medicines for preventing and treating tumors or medicines for neuroprotection. The compound is a compound shown in a formula I or a formula II or a pharmaceutically acceptable salt thereof. In the formula I, A is not present or is carbonyl, A'is carbonyl, sulfuryl, oximido and imino, R1 is amino, nitryl, acylamino, sulfonamide, aryl methoxy, aryl ethyoxyl, fluorine atom, trifluoromethyl, ureido, amidoxime, amidino and N-methyl sulfonamide, and R2 is hydrogen atom, methoxy, amino, nitryl, acylamino, amidoxime, amidino or fluorine atom; r2 and H2N-A'are located at the adjacent position of a benzene ring, R2 or H2N-A 'is located at the para-position of phenyl, and X1 and X2 are independently selected from CH or N. The phenyl naphthalene derivative provided by the invention has relatively high NQO2 inhibitory activity, and can be used as a chemical drug for tumor treatment and a neuroprotective agent for neurological diseases.

The invention discloses a method for synthesizing 9,10-bis[N-(2-naphthyl)anilino]anthracene without metal catalysis, relates to the technical field of organic luminescent material preparation, and aims to solve the problems of large amounts of waste generated and complex steps in existing methods. The method comprises the following steps: adding refined anthracene, N-phenyl-2-naphthylamine, an oxidant, an additive, and a solvent into a reaction vessel under an oxidizing atmosphere; heating the reaction after the addition is completed, heating the temperature to reflux or 80°C to 120°C, reacting for 8 to 15 hours, and cooling the temperature to room temperature, directly filtering to obtain a crude product, and separating to obtain 9,10-bis[N-(2-naphthyl)anilino]anthracene. The method has simple steps and is easy to operate, requiring only mixing all raw materials, heating the reaction, and then separating. The raw materials are low in cost and readily available, do not require a catalyst, are free of metal, and effectively avoid metal residues in the later stage. The method has simple post-processing, reduces the amount of three wastes, and has excellent purity and considerable yield, thus conforming to the development direction of green chemistry.

The invention relates to a chiral phosphine ligand as well as a preparation method and application thereof in asymmetric reaction. The structural general formula of the chiral phosphine ligand is as follows: # imgabs0 #, wherein R is selected from aryl, alkyl of C1-10 or cycloalkyl of C1-10; r1 is selected from C1-6 alkyl, phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl or heteroaryl; r2 is selected from hydrogen, aryl, alkyl of C1-6, alkoxy of C1-6, or a ring formed by bonding substituent groups; r3 is selected from hydrogen, C1-6 alkyl, phenyl, substituted phenyl, naphthyl or heteroaryl; and R4 is selected from hydrogen, C1-6 alkyl, phenyl, substituted phenyl, naphthyl or heteroaryl. Compared with the prior art, a series of chiral aminophosphones containing different substituent groups are prepared, and the method has the advantages of simple synthesis steps, high synthesis yield and the like.

The invention relates to the technical field of chemical component detection, and particularly discloses fluorescent test paper, a fluorescence analysis method and a fluorescence analysis device for visual online detection of soil nitrate nitrogen. According to the test paper, nitrate nitrogen is reduced into nitrite nitrogen by adopting zinc powder and a cadmium chloride solution, and then the nitrite nitrogen is dropwise added to fluorescent test paper prepared by soaking a mixed solution of para aminobenzoic acid, N-phenyl-1-naphthylamine and hydrochloric acid; under an acidic condition, nitrite nitrogen and para aminobenzoic acid generate diazonium salt, and then the diazonium salt reacts with N-phenyl-1-naphthylamine to form an azo compound, so that the original blue fluorescence on the test paper is gradually weakened along with the increase of the concentration of the nitrate nitrogen. According to the method, high-sensitivity and specific recognition of nitrate nitrogen is realized. And in combination with color identification and data analysis software of a smart phone, a portable and low-cost field detection system is constructed, and an efficient and practical new technical means is provided for visual quantitative detection of soil nitrate nitrogen.

This invention relates to the field of medicinal chemistry, specifically disclosing a triazole-fused piperidinone derivative, its preparation method, and its application. The triazole-fused piperidinone derivative has the structure shown in Formula I; wherein, R... 1 Selected from alkyl, phenyl, substituted phenyl, naphthyl ring, furan ring, thiophene ring, or pyridine ring; R 2 Selected from alkyl, allyl, or benzyl; R 3 The derivatives are selected from alkyl, phenyl, substituted phenyl, acyl, or sulfonyl groups. Studies have shown that the triazole-fused piperidinone derivatives described herein possess certain antiviral activity. Furthermore, the preparation method described in this invention can be carried out under mild conditions, is simple to operate, involves few steps, has good functional group compatibility, and yields high results. Therefore, this method has promising application prospects in pharmaceutical industrial production.

The invention relates to a linear acrylate monomer and preparation thereof. The linear acrylate monomer is an acrylate-terminated monomer containing an alkynyl side chain; aryl of an alkynyl side chain contains at least one of phenyl, naphthyl, benzofuryl, benzothienyl and benzothiazolyl; the terminal group forming the alkynyl side chain is alkyl, alkyl ether or ester group, and the method for preparing the retardation film from the linear acrylate monomer comprises the following steps: forming a film under the condition of at least containing an ultraviolet initiator, and then polymerizing to form the film under the condition of light exposure.

The invention provides a deuterated composition containing a phenyl naphthyl anthracene compound and the phenyl naphthyl anthracene compound. The phenyl naphthyl anthracene compound has a structure as shown in the following formula (I). The deuterated composition containing the phenyl naphthyl anthracene compound and the phenyl naphthyl anthracene compound provided by the invention can be used as a main body material of a luminescent layer of an OLED luminescent device, so that the OLED luminescent device has relatively low driving voltage, relatively high current efficiency and relatively long service life.

The present invention relates to a heat-sensitive recording material comprising: a support substrate having a first side and a second side facing away from the first side; and a heat-sensitive color-forming layer arranged on the first side of the support substrate, wherein the heat-sensitive color-forming layer comprises at least one color former, at least one color developer, and at least one stabilizer; wherein the at least one stabilizer is selected as a compound of formula (1), Ar 1 -SO2-NH-C6H4-SO2-C6H4-NH-CO-NH-Ar 2 , where Ar 1 and Ar 2 independently of each other are an unsubstituted or substituted phenyl residue, and / or wherein at least one stabilizer is selected as a compound of formula (2), Ar 1 -NH-CO-NH-C6H4-SO2-O-C6H4-NH-CO-NH-Ar 2 , where Ar 1 and Ar 2independently of one another are an unsubstituted or substituted phenyl, naphthyl and / or heteroaryl residue; wherein the weight ratio of stabilizer to color developer in the heat-sensitive color-forming layer is selected such that, according to stability test 1 defined in the description, after a storage period of 7 days under dry storage conditions, the remaining optical density of the heat-sensitive color-forming layer is at least 85% of the original optical density of the heat-sensitive color-forming layer before storage, and / or that, according to stability test 2 defined in the description, after a storage period of 7 days under humid storage conditions, the remaining optical density of the heat-sensitive color-forming layer is at least 80% of the original optical density of the heat-sensitive color-forming layer before storage;and / or that, according to the stability test 3 defined in the description, after a storage period of 7 days, the remaining optical density of the heat-sensitive color-forming layer is at least 70% of the original optical density of the heat-sensitive color-forming layer before storage.

Provided is a synthetic intermediate having a core skeleton structure of formula (I) for preparing a photochromic indole naphthopyran compound: wherein m is 0 to 4, n is 0 to 4, R 1 and R 2 R is independently hydroxy, cyano, (meth)acrylate, amino, halide, substituted or unsubstituted alkyl, borate, boric acid, polyether, polyester, polycarbonate, polyurethane, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted arylthio, ketone, aldehyde, ester, carboxylic acid, carboxylate, amide, carbonate, carbamate, urea, siloxane, alkoxysilane, or polysiloxane; 3 is substituted or unsubstituted 2-pyridyl or substituted or unsubstituted 2-quinolyl; and R 4 is hydrogen, substituted or unsubstituted alkyl, alkoxymethyl, substituted or unsubstituted silyl, or acyl. Also provided is a method for producing an indole naphthol compound, the method comprising cyclizing a phenylnaphthol compound of formula (I) in the presence of a catalyst.

The present application aims to provide a triazine compound which is useful in producing an organic electroluminescent element having excellent driving voltage and durability. A triazine compound represented by formula (1). In formula (1), A, B represent an aryl group having 6 to 20 carbon atoms. L represents a phenyl group, a naphthyl group. n is 0 or 1. C represents any one of the following X, Y, Z. Ar 1 , Ar 2 represents an aromatic hydrocarbon group or a pyridyl group.

The invention discloses a preparation method of an N-hydroxyformamidine compound, which comprises the following steps: under the protection of inert gas, mixing compounds as shown in a formula (I) and a formula (II) with hexamethyldisilylamino alkali according to a molar ratio of 1: 1: 3 in an aprotic solvent for reaction, then adding water for quenching, filtering, washing, drying by distillation under reduced pressure, and carrying out column chromatography separation to obtain a product (III); wherein Ar1 is selected from phenyl or substituted phenyl, and Ar2 is selected from any one of phenyl, substituted phenyl and naphthyl. The method is free of metal catalysis, mild in reaction condition, efficient, simple and convenient to operate and good in substrate universality.

The present invention relates to a process for the manufacture of a liquid additive comprising an amine of formula (1), wherein the process comprises the steps of: alkylating a phenyl-alpha-naphthylamine with an olefin selected from linear or branched C8-C12 olefins to obtain a first crude product comprising the amine of formula (1); distilling off unreacted olefins from the first crude product to obtain a second crude product; and distilling off unreacted phenyl-alpha-naphthylamine from the second crude product to obtain the liquid additive. The invention also relates to a liquid additive comprising an amine of formula (1) and a phenyl-alpha-naphthylamine wherein the liquid additive comprises at least 95 wt% of the amine of formula (1) and wherein the concentration of the phenyl-alpha-naphthylamine in the liquid additive is less than 0.2 wt%, preferably less than 0.1 wt%. The invention further relates to the use of the liquid additive, such as in lubricants.

The invention relates to the technical field of heat treatment quenching media, in particular to quenching oil special for 05Cr15Ni5Cu4Nb precipitation hardening stainless steel and a preparation method and application of the quenching oil. The special quenching oil for the 05Cr15Ni5Cu4Nb precipitation hardening stainless steel is prepared from the following components in percentage by mass: 88 to 95 percent of base oil combination, 1.5 to 5.0 percent of quick cooling agent, 2.0 to 3.5 percent of antioxidant and 1.0 to 4.0 percent of dispersing agent, the base oil composition is a mixture composed of refined hydrogenated mineral oil 150N and refined hydrogenated mineral oil 500N; the quick cooling agent is polyisobutene; the antioxidant is a combination of phenyl-alpha-naphthylamine and dialkyl dithiophosphate carbamate, or a combination of phenyl-alpha-naphthylamine and dilauryl thiodipropionate, and the antioxidant is a combination of phenyl-alpha-naphthylamine and dilauryl thiodipropionate. Through base oil compounding and rapid cooling agent dosage optimization, the step quenching effect of high-temperature rapid cooling and low-temperature slow cooling is achieved, martensite transformation of a 05Cr15Ni5Cu4Nb precipitation hardening stainless steel workpiece is stably completed near the Ms point, and a uniform and fine lath martensite structure is provided for subsequent aging strengthening.

The invention belongs to the field of organic chemistry, and relates to a chiral spiro-oxoindole compound and a synthesis method thereof. The chiral spiro-oxoindole compound is a compound with a structure as shown in a formula (1), or an epoxide or a hydrogenation product thereof: # imgabs0 # in the formula (1), R1 is methyl or benzyl; r2 is at least one of hydrogen, alkyl of C1-C4, alkoxy of C1-C4 and halogen; r3 is phenyl, substituted phenyl, naphthyl or phenyl (C1-C4) alkyl, and preferably, the substituent group of the substituted phenyl is at least one of hydrogen, C1-C4 alkyl, C1-C4 alkoxy and halogen. A series of chiral spiro-oxoindole derivatives are efficiently constructed by using oxoindole ketene generated by a simple and easily available diazo compound under the illumination condition and alkenyl oxygen heterocyclic propane under the conditions of a metal catalyst and a chiral ligand, and a simple and efficient new method is provided for synthesizing bioactive molecules containing the skeleton.

The invention belongs to the technical field of transformer insulating oil, and discloses a synthetic ester insulating oil double-effect improver as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out primary reaction on an N-phenyl-alpha-naphthylamine solution, a hindered phenol solution and triethylamine; then adding methyl iodide and triethylamine to carry out secondary reaction; and adding hydrochloric acid for neutralization, drying with anhydrous sodium sulfate, carrying out rotary evaporation, and finally purifying to obtain the synthetic ester insulating oil double-effect improver. By introducing polycyclic aromatic hydrocarbon and methoxyl, the oxidation resistance of the synthetic ester is improved; the methoxyl group improves the ultraviolet light absorption capability, and reduces the molecular excitation caused by high-energy ultraviolet light in the insulating oil, thereby inhibiting the formation of a streamer channel. The double-effect improver provided by the invention not only is obviously superior to the traditional antioxidant in oxidation resistance, but also can obviously improve the electric shock resistance of the synthetic ester insulating oil in a high-temperature and high-pressure environment, and is suitable for high-voltage and large-sized transformers and other electrical equipment needing long-time stable operation.

TIFF2025524984000197.tif61152 [Chemical 2] A compound having the structure of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt [wherein, R is H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2) m Selected from the group consisting of -W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, naphthyl, a 5- or 6-membered heteroaryl or heterocyclic containing 1, 2 or 3 heteroatoms selected from the group consisting of N, S and O atoms, and each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R’, -CONR’R’’, NR’COR’’, -NR’CONR’R’’, -NR’CO2R’’, -(CH2) n -SO2-R’, -NHSO2-R’, -NR’’SO2-R’, -SO2NR’R’’, NR’R’’ or SR’ and may be substituted, and R’ and R’’ are independently H, C1-C6 alkyl or C3-C8 cycloalkyl, and R1 is phenyl, naphthyl, a 5- or 6-membered heteroaryl or heterocyclic containing 1, 2, 3 or 4 heteroatoms selected from the group consisting of N, S and O atoms, and a 9- or 10-membered bicyclic aryl, a heteroaryl or heterocyclic containing 1, 2 or 3 heteroatoms selected from the group consisting of N, S and O atoms, and each of said phenyl, naphthyl, aryl, heterocyclic, or heteroaryl may be unsubstituted or halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, phenyl, -SO2-R’, -CONR’R’’, NR’COR’’, -NR’CONR’R’’, -NR’CO2R’’, -(CH2) n-SO2-R’, -NHSO2-R’, -NR’’SO2-R, -SO2NR’R’’, -P(O)R’R’’, may be substituted by formula (Ic) or NR’R’’’ or SR’, R’ and R’’ are independently H, C1-C6 alkyl or C3-C8 cycloalkyl, and m and n are independently 0, 1, 2 or 3]. The present invention also relates to pharmaceutically acceptable salts of these compounds and their pharmaceutically acceptable solvates, compositions containing such compounds, and the use of such compounds in the treatment of various diseases, particularly acne.

The invention discloses a gemcitabine prodrug or pharmaceutically acceptable salt, tautomer, meracemate, racemate, stereoisomer or solvate of the gemcitabine prodrug, wherein the structure of the gemcitabine prodrug is shown as a formula I; R1 and R2 are independently selected from H, C1-C6 alkyl or C1-C6 alkyl, one or more hydrogen in the C1-C6 alkyl can be substituted by R3, and benzyl or benzyl of which hydrogen on a benzene ring is substituted by R4, or a pharmaceutically acceptable salt, tautomer, meracemate, racemate, stereoisomer or solvate of the gemcitabine prodrug, or pharmaceutically acceptable salt, tautomer, meracemate, racemate, stereoisomer or solvate thereof; x is selected from S or O; y is selected from S or O; ar is selected from phenyl, 1-naphthyl or 2-naphthyl; r3 is hydroxyl, halogen, C3-C6 cycloalkyl, phenyl or R4 substituted phenyl; and R4 is hydroxyl, halogen, cyano, nitro or methoxyl. The gemcitabine prodrug disclosed by the invention can be activated by ROS, has stronger tumor targeting property and ideal antitumor activity, and is less influenced by cytidine deaminase and nucleoside transporter. The invention also discloses an application of the gemcitabine prodrug or the pharmaceutically acceptable salt thereof in preparation of antitumor drugs. # imgabs0 #