8720 results about "Aryl" patented technology

The present disclosure relates to a fused heteroaryl compound, a preparation method therefor, and a use thereof in medicine. Specifically, the present disclosure relates to a fused heteroaryl compound represented by general formula (I'), a preparation method therefor, a pharmaceutical composition containing said compound, and a use thereof as a therapeutic agent, especially a use thereof in the preparation of a medicament for inhibiting KRAS amplification and / or mutant activity. Each group in general formula (I') is as defined in the description.

Compounds represented by general formula (I), or stereoisomers, tautomers, deuterated substances, solvates, prodrugs, metabolites, and pharmaceutically acceptable salts or eutectic crystals thereof, an intermediate thereof, and the use thereof in diseases related to KRAS inhibition or degradation such as cancers.

The invention relates to a disubstituted nitrogenous five-membered heteroaryl compound serving as a kinase inhibitor and application of the disubstituted nitrogenous five-membered heteroaryl compound. The chemical structure of the disubstituted nitrogenous five-membered heteroaryl compound disclosed by the invention is shown as a formula A, the compounds of the invention are CHK1 inhibitors. Therefore, the compounds of the present invention can be used for the treatment of cancer. # imgabs0 #

Provided herein are novel compounds (e.g., Formula K), pharmaceutical compositions, and methods of use for treating a variety of diseases or disorders, such as cancer.

The invention relates to the technical field of polymer synthesis, in particular to polyaryletherketone resin containing imide side groups and a preparation method of the polyaryletherketone resin. By introducing an imide structure into aryl diphenol containing amino, a plurality of polyaryletherketone resins containing imide side groups are designed and synthesized, and are used for meeting various application requirements, such as high-performance materials, electronic materials, optical materials and the like; meanwhile, the performance of the polyaryletherketone material is also improved, so that the polyaryletherketone material is more suitable for various application environments.

The invention relates to the technical field of organic photoelectric materials, in particular to a triazine compound, an OLED with the compound and an organic light-emitting device with the compound. According to the triazine compound disclosed by the invention, a triazine structure is taken as a core, and aryl and alkyl are combined with a fluorenyl group to form side chain matching, so that the compound has excellent luminous efficiency and relatively good thermal stability; meanwhile, when the triazine compound provided by the invention acts on a device, the organic light-emitting device can effectively have lower driving voltage and maintain the stability of the voltage, the light-emitting efficiency is improved, the service life is obviously prolonged, and the triazine compound has a very good application prospect.

The invention relates to a fused heteroaryl compound, a preparation method thereof and application of the fused heteroaryl compound in medicine. Specifically, the invention relates to a fused heteroaryl compound as shown in a general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound and application of the compound as a therapeutic agent, in particular to application of the compound in preparation of drugs for inhibiting KRAS amplification and / or mutant activity. Wherein each group in the general formula (I) is defined in the specification. # imgabs0 #

The invention belongs to the field of organic photoelectric materials, and discloses an electroluminescent material and a preparation method and application thereof. The structure of the electroluminescent material is as shown in a formula I: # imgabs0 #. According to the electroluminescent material compound provided by the invention, on the basis of a 9-methyl-9-phenylfluorene group, triarylamine and an aromatic ring are connected through 2 and 4 sites, when the triarylamine group is substituted by aryl, the energy level is relatively low, carrier migration localization is avoided, and a hole transport energy barrier can be reduced, so that the migration rate and the luminous efficiency are improved; triarylamine has excellent hole transport performance, a triarylamine material is used as a light-emitting auxiliary layer, a group with a high triplet state energy level is introduced, the energy range between energy levels can be reduced, and the service life of the device is greatly prolonged.

An aqueous ultraviolet-absorbing resin emulsion, and an aqueous resin emulsion composition containing the emulsion is provided, wherein the emulsion is excellent in compatibility with a synthetic resin and light resistance. Also, the emulsion improves stability in blending with an aqueous emulsion of the synthetic resin, and prevents bleed out of the ultraviolet-absorbing resin on the surface of a coating film. Further, the aqueous ultraviolet-absorbing resin emulsion imparts excellent alkali or solvent resistance to a synthetic resin poor in alkali or solvent resistance. More specifically, an aqueous resin emulsion composition comprising (I) an aqueous ultraviolet-absorbing resin emulsion and (II) an other aqueous resin emulsion is provided, wherein the emulsion (I) is obtained by urethanizing (A) a polyol component having an ultraviolet-absorbing group {e.g., 1,1-bis[3-(2H-benzotriazol-2-yl)-4-hydroxy-benzeneethanol]methane}, (B) a polyol if necessary, (C) an alkyl or aryl dialkanolamine compound, and (D) an organic polyisocyanate in (E) an organic solvent, diluting the reaction mixture with (F) an organic solvent having a boiling point lower than 100° C. to give a resin solution, neutralizing the resin solution with (G) a neutralizing agent, and dispersing the resultant in water.

The invention relates to a compound shown in a general formula (I) or a stereoisomer, a tautomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or co-crystal of the compound, an intermediate of the compound, and application of the compound in inhibiting or degrading KRAS related diseases such as cancers. # imgabs0 #

The invention provides a novel polynorbornene anion exchange ionomer containing a polar functional group as well as a preparation method and application of the novel polynorbornene anion exchange ionomer. The polynorbornene has excellent thermal stability and chemical stability. Meanwhile, the AEI main chain of the polynorbornene has no aryl group, so that the adsorption influence caused by the aryl group is avoided. The synthesized addition polynorbornene AEI in the form of quaternary ammonium salt can be dissolved in a low-boiling-point solvent, and it is ensured that a membrane electrode can be prepared through a solvent casting method. Besides the solubility of the AEI, the addition polynorbornene-based AEI in the form of quaternary ammonium salt is modified by utilizing a thiol-ene click reaction, an anion exchange ionomer containing a polar functional group can be prepared, the interaction between the AEI and an electrolytic catalyst is improved, the reaction is simple and easy to operate, the universality is high, and the method is suitable for industrial production. And the current density in the AEMWE system containing the AEI can be effectively improved.

The present invention relates to novel (3,3-dimethyl-2-oxo-butoxy)phenyl derivatives and (2- aryl-2-oxo-ethoxy]phenyl derivatives and to their application in a process for the preparation of (3,3,3-trifluoro-2-oxo-propoxy)phenyl derivatives and their further transformation into [(2- trifluoromethyl-1,3-dioxolan-2-yl)methoxy]phenyl derivatives and (2-ethoxy-3,3,3-trifluoro- prop-1-enoxy)phenyl derivatives suitable for use, e.g., as active ingredients, which have microbiocidal activity, in particular, fungicidal activity.

The invention relates to an electrode plate and a preparation method thereof, a battery and a power utilization device, the electrode plate comprises a current collector and an electrode film layer arranged on the surface of the current collector, the component of the electrode film layer comprises a silicon compound, and the silicon compound has a group represented by a formula (A); wherein each R1 is independently selected from any one of hydrogen, substituted or unsubstituted alkyl, alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and unsaturated alkyl, and each R1 is not hydrogen at the same time; '*' represents a site where the group shown in the formula (A) is connected with other structures in the silicon compound; # imgabs0 #

The invention belongs to the technical field of pesticides, and particularly relates to a mesoionic pyrimidinium compound, and an N-oxide or salt and application thereof. The compound is shown as a general formula I: # imgabs0 #, wherein X represents a cyano group, a cyano alkyl group, an aryl group or a heterocyclic group; q1 and Q2 independently represent O or S respectively; m1, M2, M3, M4 and M5 respectively and independently represent CR9 or N, and at least two of the M1, M2, M3, M4 and M5 are N; r1, R2, R3, R4, R5, R6, R7, R8 and R9 independently represent hydrogen, nitro, amino, cyano, halogen and the like respectively. The compound has excellent prevention and control effects on pests such as chilo suppressalis, spodoptera frugiperda, armyworm, prodenia litura, peanut aphid and rice planthopper, and is safe to bees.

Disclosed is a printing ink for heat-sensitive recording media, which is (A) or (B) below: (A) a heat-sensitive color-developing printing ink containing a leuco dye, a color developer, a vinylpyrrolidone-vinyl acetate copolymer, and a solvent, wherein the color developer is at least one selected from the group consisting of an N,N'-diaryl urea-based compound represented by general formula (1) (in the formula, R0 represents a C1-12 alkyl group, a C7-12 aralkyl group, or a C6-12 aryl group. The aralkyl group and the aryl group may be substituted with a C1-12 alkyl group, a C1-12 alkoxy group, a C6-12 aryl group, or a halogen atom. A plurality of R0s may be the same or different. A1 represents a hydrogen atom or a C1-4 alkyl group. A plurality of A1s may be the same or different.), a compound represented by general formula (2) (in the formula, R1 to R5 are the same or different, and represent a hydrogen atom, a halogen atom, a nitro group, an amino group, an alkyl group, an alkoxy group, an aryloxy group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an alkylcarbonylamino group, an arylcarbonylamino group, an alkylsulfonylamino group, an arylsulfonylamino group, a monoalkylamino group, a dialkylamino group, or an arylamino group.), and 5-(N-3-methylphenyl-sulfonamide)-N',N''-bis-(3-methylphenyl)-isophthalic acid diamide; and (B) a protective layer printing ink for heat-sensitive recording media, the protective layer printing ink containing an adhesive, a slipperiness imparting agent, and a solvent, wherein the adhesive is a polyvinyl acetal resin, and the slipperiness imparting agent is an alkyl phosphate ester and / or a salt thereof.

The invention belongs to the technical field of chemistry, and particularly relates to a diaryl methyl pyrimidine piperazine compound as well as a preparation method, a pharmaceutical composition and application thereof. The structural formula of the diaryl methyl pyrimidine piperazine compound is shown as a formula I, and R is a substituted aromatic group. The preparation process is simple, the prepared diaryl methyl pyrimidine piperazine compound or the pharmaceutically acceptable salt thereof has the activity of efficiently inhibiting WDR5-MLL 1, and a targeted therapy scheme and novel, safe and efficient candidate drug molecules are provided for treating acute myeloid leukemia with WDR5-MLL fusion mutation. Experimental results show that the tumor inhibition rates of mouse tumor-bearing groups treated by the compounds 5c, 5k and 5l prepared by the invention are 79%, 85% and 75% respectively and are superior to those of a positive control group, and the compounds have good development prospects.

The present disclosure is directed to inhibitors of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

The invention provides a polymer, a cross-linked anion exchange membrane and a preparation method and application thereof. According to the polymer and the cross-linked anion exchange membrane, aryl compounds, trifluoroketone compounds and N-methylpiperidone are polymerized to form a main chain, the main chain has excellent rigidity and flexibility, a quaternary ammonium salt alkenyl compound is introduced as a cross-linking agent, cross-linking is completed through heating in the membrane forming process, and the cross-linked anion exchange membrane is prepared. The quaternary ammonium salt side chain introduced into the side chain has excellent hydrophilic and hydrophobic phase separation characteristics. The polymer and the cross-linked anion exchange membrane have excellent oxidation-reduction resistance and alkali resistance, have the characteristics of stable physical and chemical properties, excellent ion flux, excellent mechanical properties (the elongation at break is greater than 60%) and simple process, and can be widely applied to the fields of hydrogen production by water electrolysis and the like.

The invention relates to the field of concrete admixtures, in particular to a high-temperature-resistant early-strength slump-retaining polycarboxylate superplasticizer as well as a preparation method and application thereof. The high-temperature-resistant early-strength slump-retaining polycarboxylate superplasticizer provided by the invention contains unsaturated aryl imide silane which can accelerate the cement hydration acceleration period and shorten the concrete setting time, and cooperates with an imide group to improve the heat resistance of a polymer, and then the heat resistance of the polymer is further improved by virtue of the micro-crosslinking effect of N, N-methylene bisacrylamide, so that the high-temperature-resistant early-strength slump-retaining polycarboxylate superplasticizer is prepared. A huge three-dimensional adsorption structure is formed through high-hydrophilic groups such as phosphate groups and benzene rings in the molecular structure and rigid groups, steric hindrance is increased, the slump retention capacity of concrete is improved, a large number of hydrophilic groups such as carboxyl and hydroxyl can form hydrogen bonds with water molecules, the strength of concrete is enhanced, and the concrete is applied to concrete production and has good application prospects. The premixed concrete has the advantages and technical effects that the premixed concrete still has good fluidity and slump retentivity in a high-temperature environment, the setting time is short, and the early strength is high.

A heteroaryl compound, a preparation method therefor, and a use thereof in medicine. Specifically, provided are a heteroaryl compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof as a therapeutic agent, especially a use thereof as a PRMT5 inhibitor and a use thereof in treating and / or preventing cancer.

Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with abnormal levels of amino acids by modulation of SLC6A19 transport.

The present invention makes it possible to provide a thermoplastic resin including a constituent unit (A) derived from a monomer represented by general formula (1). (In the formula, each R1 independently represents a C6-14 aryl group or a C7-17 aralkyl group, each R2 independently represents a hydrogen atom, a C6-14 aryl group, or a C7-17 aralkyl group, each a independently represents an integer of 0 or 1-3, each R3 independently represents -OH or -0-(CH2)n-OH, and n represents an integer of 1-4.)

The invention provides a high-insulation black organic silicon coloring agent and a preparation method thereof. The high-insulation black organic silicon coloring agent comprises the following raw materials in parts by mass: 100 parts of a silicone oil carrier; 3-5 parts of passivated carbon black; 1-3 parts of fumed silica; wherein the passivated carbon black comprises carbon black and an organic silicon layer coated on the surface of the carbon black; the organic silicon layer is obtained by graft polymerization of polymethyltriethoxysilane and a functionalized silane coupling agent on the surface of the carbon black; the functionalized silane coupling agent comprises at least one of an aryl silane coupling agent and a fluorine-containing silane coupling agent. According to the black coloring agent, the advantage of high blackness of carbon black is maintained, meanwhile, the electric insulation performance and dispersion stability of the black coloring agent in a silicone oil system are remarkably improved, the problems that the carbon black is high in conductivity, poor in interface compatibility and prone to agglomeration are solved, and the black coloring agent is especially suitable for being applied to organic silicon materials with the high requirement for the insulation performance.

The invention belongs to the technical field of organic light-emitting materials, and relates to a boron-containing polycyclic compound for an organic light-emitting material. According to the invention, aryl or heteroaryl is taken as a center, 2-3 boron atoms are introduced and form covalent bonds with atoms such as N, O, S and Se, and a rigid polycyclic compound is constructed. The compound provided by the invention is a boron-containing polycyclic compound with multiple resonance effects, can realize narrow-spectrum and high-color-purity luminescence, also has efficient TADF characteristics, and significantly improves the performance of OLED devices. Compared with the prior art, the compound has remarkable advantages in the aspects of molecular structure design, photoelectric property regulation and control, application range and the like, provides important technical support for development of new-generation high-performance OLED materials, and has wide market prospects and application potential.

The invention discloses a compound and an organic electroluminescent device, and relates to the technical field of organic electroluminescence, the compound at least contains more than one deuterium at a specific position of a benzene ring substituent group, and the introduction of deuterium, aryl or deuterated aryl groups at the position greatly improves the thermal stability and chemical stability of a material. And the service life of the device is prolonged. Meanwhile, larger steric hindrance and torque, better stability, better solubility, higher efficiency and longer service life are achieved.

The invention provides a chiral resolution method and application of a 3-aryl substituted glutaric acid monoester compound, and the method comprises the following steps: taking a substance as shown in a formula I as a starting raw material, and carrying out alcoholysis to obtain a racemic intermediate as shown in a formula IV; and splitting the intermediate shown in the formula IV, and then dissociating to obtain the compound shown in the formula III, which has a single spatial configuration and an ee value of more than 99%. A cyclic anhydride substrate with a symmetrical structure is used and reacts with alcohol to obtain racemic 3-aryl substituted glutaric acid monoester, a target configuration with high chiral purity is obtained by screening some resolution reagents and solvents and performing salifying resolution on the 3-aryl substituted glutaric acid monoester, the operation is simple, the resolution reagents are easily available in the market and can be recycled, and the method is suitable for industrial production. The method has the advantages that an expensive chiral catalyst or a harsh enzyme catalysis condition is avoided, the reaction cost is reduced, amplified production is facilitated, the ee value of a target configuration can be increased to 99% or above, and the method is an economic and environment-friendly technical route which is simple in post-treatment and convenient for amplified production.

Provided is an arylalkyl-modified indene composition comprising a plurality of compounds, each of the compounds having one or more arylalkyl groups on an indene ring and differing from the others in the number of arylalkyl groups in one molecule. The content of the compound or compounds having a single arylalkyl group in one molecule is 1% or less in the composition at the percentage calculated on the basis of the area ratio in a GPC chart. At least one of the arylalkyl groups present in the composition is an arylalkyl group having a polymerizable unsaturated bond-containing group, while at least one of the arylalkyl groups present in the composition is an arylalkyl group having no polymerizable unsaturated bond-containing group.

The invention belongs to the technical field of high polymer materials, and particularly relates to spinning-grade all-aryl polynaphthyl ester resin and a preparation method thereof. According to the invention, p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic acid, aromatic dicarboxylic acid and ethylene glycol monomer are adopted as raw materials, polymerization reaction is carried out under the action of the catalyst, spinning-grade all-aryl polynaphthyl ester resin is successfully obtained under specific reaction conditions, and the spinning-grade all-aryl polynaphthyl ester resin has high molecular weight, low impurity content and good heat resistance, and can be used for preparing the spinning-grade all-aryl polynaphthyl ester resin. The melt fluidity is good, the shear thinning phenomenon is more obvious, and the method can be directly used for preparing the polynaphthalene ester fiber.

The invention belongs to the technical field of organic silicon damping materials, and particularly relates to a polyborosiloxane type damping additive for phenyl siloxane rubber as well as a preparation method and application of the polyborosiloxane type damping additive. The polyborosiloxane type damping additive for phenyl siloxane rubber is prepared from hydroxyl-terminated polysiloxane and a boron-containing aryl compound, and the hydroxyl ratio of the hydroxyl-terminated polysiloxane to the boron-containing aryl compound is 1: (0.2-3). From the perspective of molecular structure design, aryl groups are introduced into polyborosiloxane molecules, the obtained polyborosiloxane type damping additive has good compatibility with phenyl siloxane rubber, cannot be separated from the phenyl siloxane rubber, and can provide good damping performance for the phenyl siloxane rubber; the effective damping temperature range of the phenyl silicone rubber is greatly widened, and the requirement of the market for high-performance damping silicone rubber is met.

A corrosion inhibitor composition includes a fatty acid ethoxylate, a thiourea, an arylthiourea, a thiazole, and two or more solvents. A metal article in contact with the composition has a corrosion rate of about 25 to about 45 mils penetration per year (mpy), as determined by an ASTM G111 standard test method. A method for inhibiting corrosion of a metal in contact with a corrosive fluid.