5692 results about "Aryl" patented technology

The invention relates to a fused heteroaryl compound, a preparation method thereof and application of the fused heteroaryl compound in medicine. Specifically, the invention relates to a fused heteroaryl compound as shown in a general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound and application of the compound as a therapeutic agent, in particular to application of the compound in preparation of drugs for inhibiting KRAS amplification and / or mutant activity. Wherein each group in the general formula (I) is defined in the specification. # imgabs0 #

An aqueous ultraviolet-absorbing resin emulsion, and an aqueous resin emulsion composition containing the emulsion is provided, wherein the emulsion is excellent in compatibility with a synthetic resin and light resistance. Also, the emulsion improves stability in blending with an aqueous emulsion of the synthetic resin, and prevents bleed out of the ultraviolet-absorbing resin on the surface of a coating film. Further, the aqueous ultraviolet-absorbing resin emulsion imparts excellent alkali or solvent resistance to a synthetic resin poor in alkali or solvent resistance. More specifically, an aqueous resin emulsion composition comprising (I) an aqueous ultraviolet-absorbing resin emulsion and (II) an other aqueous resin emulsion is provided, wherein the emulsion (I) is obtained by urethanizing (A) a polyol component having an ultraviolet-absorbing group {e.g., 1,1-bis[3-(2H-benzotriazol-2-yl)-4-hydroxy-benzeneethanol]methane}, (B) a polyol if necessary, (C) an alkyl or aryl dialkanolamine compound, and (D) an organic polyisocyanate in (E) an organic solvent, diluting the reaction mixture with (F) an organic solvent having a boiling point lower than 100° C. to give a resin solution, neutralizing the resin solution with (G) a neutralizing agent, and dispersing the resultant in water.

The invention provides a novel polynorbornene anion exchange ionomer containing a polar functional group as well as a preparation method and application of the novel polynorbornene anion exchange ionomer. The polynorbornene has excellent thermal stability and chemical stability. Meanwhile, the AEI main chain of the polynorbornene has no aryl group, so that the adsorption influence caused by the aryl group is avoided. The synthesized addition polynorbornene AEI in the form of quaternary ammonium salt can be dissolved in a low-boiling-point solvent, and it is ensured that a membrane electrode can be prepared through a solvent casting method. Besides the solubility of the AEI, the addition polynorbornene-based AEI in the form of quaternary ammonium salt is modified by utilizing a thiol-ene click reaction, an anion exchange ionomer containing a polar functional group can be prepared, the interaction between the AEI and an electrolytic catalyst is improved, the reaction is simple and easy to operate, the universality is high, and the method is suitable for industrial production. And the current density in the AEMWE system containing the AEI can be effectively improved.

The invention belongs to the technical field of pesticides, and particularly relates to a mesoionic pyrimidinium compound, and an N-oxide or salt and application thereof. The compound is shown as a general formula I: # imgabs0 #, wherein X represents a cyano group, a cyano alkyl group, an aryl group or a heterocyclic group; q1 and Q2 independently represent O or S respectively; m1, M2, M3, M4 and M5 respectively and independently represent CR9 or N, and at least two of the M1, M2, M3, M4 and M5 are N; r1, R2, R3, R4, R5, R6, R7, R8 and R9 independently represent hydrogen, nitro, amino, cyano, halogen and the like respectively. The compound has excellent prevention and control effects on pests such as chilo suppressalis, spodoptera frugiperda, armyworm, prodenia litura, peanut aphid and rice planthopper, and is safe to bees.

The invention provides a polymer, a cross-linked anion exchange membrane and a preparation method and application thereof. According to the polymer and the cross-linked anion exchange membrane, aryl compounds, trifluoroketone compounds and N-methylpiperidone are polymerized to form a main chain, the main chain has excellent rigidity and flexibility, a quaternary ammonium salt alkenyl compound is introduced as a cross-linking agent, cross-linking is completed through heating in the membrane forming process, and the cross-linked anion exchange membrane is prepared. The quaternary ammonium salt side chain introduced into the side chain has excellent hydrophilic and hydrophobic phase separation characteristics. The polymer and the cross-linked anion exchange membrane have excellent oxidation-reduction resistance and alkali resistance, have the characteristics of stable physical and chemical properties, excellent ion flux, excellent mechanical properties (the elongation at break is greater than 60%) and simple process, and can be widely applied to the fields of hydrogen production by water electrolysis and the like.

The invention provides a high-insulation black organic silicon coloring agent and a preparation method thereof. The high-insulation black organic silicon coloring agent comprises the following raw materials in parts by mass: 100 parts of a silicone oil carrier; 3-5 parts of passivated carbon black; 1-3 parts of fumed silica; wherein the passivated carbon black comprises carbon black and an organic silicon layer coated on the surface of the carbon black; the organic silicon layer is obtained by graft polymerization of polymethyltriethoxysilane and a functionalized silane coupling agent on the surface of the carbon black; the functionalized silane coupling agent comprises at least one of an aryl silane coupling agent and a fluorine-containing silane coupling agent. According to the black coloring agent, the advantage of high blackness of carbon black is maintained, meanwhile, the electric insulation performance and dispersion stability of the black coloring agent in a silicone oil system are remarkably improved, the problems that the carbon black is high in conductivity, poor in interface compatibility and prone to agglomeration are solved, and the black coloring agent is especially suitable for being applied to organic silicon materials with the high requirement for the insulation performance.

The invention provides a chiral resolution method and application of a 3-aryl substituted glutaric acid monoester compound, and the method comprises the following steps: taking a substance as shown in a formula I as a starting raw material, and carrying out alcoholysis to obtain a racemic intermediate as shown in a formula IV; and splitting the intermediate shown in the formula IV, and then dissociating to obtain the compound shown in the formula III, which has a single spatial configuration and an ee value of more than 99%. A cyclic anhydride substrate with a symmetrical structure is used and reacts with alcohol to obtain racemic 3-aryl substituted glutaric acid monoester, a target configuration with high chiral purity is obtained by screening some resolution reagents and solvents and performing salifying resolution on the 3-aryl substituted glutaric acid monoester, the operation is simple, the resolution reagents are easily available in the market and can be recycled, and the method is suitable for industrial production. The method has the advantages that an expensive chiral catalyst or a harsh enzyme catalysis condition is avoided, the reaction cost is reduced, amplified production is facilitated, the ee value of a target configuration can be increased to 99% or above, and the method is an economic and environment-friendly technical route which is simple in post-treatment and convenient for amplified production.

Provided is an arylalkyl-modified indene composition comprising a plurality of compounds, each of the compounds having one or more arylalkyl groups on an indene ring and differing from the others in the number of arylalkyl groups in one molecule. The content of the compound or compounds having a single arylalkyl group in one molecule is 1% or less in the composition at the percentage calculated on the basis of the area ratio in a GPC chart. At least one of the arylalkyl groups present in the composition is an arylalkyl group having a polymerizable unsaturated bond-containing group, while at least one of the arylalkyl groups present in the composition is an arylalkyl group having no polymerizable unsaturated bond-containing group.

A corrosion inhibitor composition includes a fatty acid ethoxylate, a thiourea, an arylthiourea, a thiazole, and two or more solvents. A metal article in contact with the composition has a corrosion rate of about 25 to about 45 mils penetration per year (mpy), as determined by an ASTM G111 standard test method. A method for inhibiting corrosion of a metal in contact with a corrosive fluid.

Provided is an arylalkyl-modified indene composition that contains a plurality of types of compounds having an arylalkyl group on an indene ring, the compounds having different numbers of arylalkyl groups in one molecule, wherein: the content of a compound in which the number of arylalkyl groups in one molecule is 1 is 1% or less as calculated from the area ratio of the GPC chart; at least one of the arylalkyl groups present in the composition has a polymerizable unsaturated bond-containing group; and at least one of the arylalkyl groups present in the composition does not have a polymerizable unsaturated bond-containing group.

The invention discloses a compound containing a urea structure as well as a preparation method and application of the compound in a color developing agent, and relates to the technical field of color developing agents. The compound containing the urea structure is a # imgabs0 # structure as shown in a formula 1. The compound containing the urea structure is synthesized through multiple steps of Suzuki reaction, bromination reaction and substitution reaction. The compound is used as an electron donor to be applied to a thermosensitive color development system and forms a color development composition with a phenolic compound and an acidic material, and the activation temperature is as low as 60-120 DEG C. The ureido structure stabilizes a reaction intermediate through a hydrogen bond network, enhances the electron transfer efficiency, and significantly improves the color developing sensitivity; the aryl / heteroaryl substituent optimizes the color contrast through the conjugation effect, and meanwhile, the synergistic effect of the hot-melt filler ensures the stability of the system. Compared with a traditional color developing agent, the color developing agent has the advantages of low-temperature activation, high color developing intensity and excellent weather resistance, is suitable for the fields of thermal printing, anti-counterfeiting materials and the like, and overcomes the defects of high reaction temperature and insufficient stability in the prior art.

This method for producing an aryl-alkylated indene composition involves: adding an arylalkyl group having a polymerizable unsaturated bond-containing group to an indene compound; and adding an arylalkyl group having no polymerizable unsaturated bond-containing group to the indene compound to which the arylalkyl group having a polymerizable unsaturated bond-containing group is added.

The invention relates to an organic molecule, in particular for the application in optoelectronic devices. According to the invention, the organic molecule includes or consists of a structure represented by Formula IwhereinR1 is selected from the group consisting of hydrogen and C6-C12-aryl, which is optionally substituted with one or more C1-C6-alkyl substituents, andRa is at each occurrence independently selected from the group consisting of: hydrogen, deuterium, N(R5)2, OR5, Si(R5)3, B(OR5)2, B(R5)2, OSO2R5, CF3, CN, F, Br, I, C1-C40-alkyl, C1-C40-alkoxy, C1-C40-thioalkoxy, C2-C40-alkenyl, C2-C40-alkynyl, C6-C60-aryl, and C2-C57-heteroaryl.

Provided is an anthraquinone derivative represented by formula (9-1). In formula (9-1), R1 and R2 are each independently an amino group or a hydroxyl group and Y1, Y2, and Z are each independently a hydrogen atom, a C1-C10 alkyl group, a C1-C10 alkoxy group, a cyano group, a nitro group, a halogen atom, a C1-C10 halogenated alkyl group, an amino group, an alkylamino group, a piperidyl group, an aryl group, or a cyclohexyl group, the aryl and cyclohexyl groups being optionally substituted.　

The invention relates to the technical field of quantum computing and molecular electronic devices, in particular to a probabilistic bit device based on polyfluoroaryl methyl free radicals and a preparation method of the probabilistic bit device. According to the probabilistic bit device, the coupling efficiency of molecules and electrodes is improved by virtue of the characteristic that the paramagnetic unpaired electron spin state of tri (polyfluoroaryl) methyl free radical molecules can be used as a random expansion physical entropy source and high electronegativity and stability formed by modification of a plurality of strong electron-withdrawing fluorine atoms in the molecules. During the operation period of the device, the spin fluctuation can efficiently regulate and control tunneling current passing through molecules, promote random conversion between output high and low current states, show excellent random binary fluctuation characteristics, and simultaneously have high sensitivity and long coherence time. Compared with the prior art, the device has remarkable advantages in the aspects of device stability, energy efficiency ratio and external field controllability. The preparation method is simple and convenient to operate, mild in reaction condition and beneficial to large-scale production.

The invention discloses an organic electroluminescent material and an organic electroluminescent device and application thereof.The organic electroluminescent material can serve as a functional layer of the organic electroluminescent device, 9-alkyl-9-phenyl-9H-fluorene serves as a parent nucleus and is directly connected with arylamine on the parent nucleus, one side chain of the arylamine is aryl or heteroaryl, the other side chain of the arylamine is 1, 1, 4, 5, 6-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1, 3-tetramethyl-1 Compared with other compounds, the organic electroluminescent material compound disclosed by the invention has the advantages that the transverse electric leakage is small, and the phenomena that adjacent pixels are lightened, transverse crosstalk is generated between adjacent sub-pixels and color display is influenced due to transverse leakage current of the adjacent pixels in a device can be reduced. The organic electroluminescent material is used as a functional layer of the organic electroluminescent device, and the problems that color display is affected and picture display is abnormal due to transverse electric leakage of an OLED display device can be solved.

The invention relates to a method for continuously synthesizing a dapagliflozin intermediate, and belongs to the technical field of drug intermediate synthesis. The method comprises the following steps: mixing 5-bromo-2-chloro-4 '-ethoxydiphenylmethane, a photocatalyst and THF (tetrahydrofuran), introducing the mixture into an ultraviolet light catalytic micro-channel for pre-activation to generate an aryl free radical intermediate, namely a pre-activation solution, carrying out contact reaction on the pre-activation solution and a THF solution of 2, 3, 4, 6-tetra-O-trimethylsilyl-D-glucolactone in a low-temperature coupling area of a micro-reactor, and carrying out purification, purification and purification to obtain the aryl free radical intermediate. The reaction liquid is introduced into a dynamic quenching zone and is mixed with supercritical CO2 on line, an intermediate I is obtained through supercritical fluid extraction and separation, and the photocatalyst is recycled; the method has the advantages of high reaction efficiency, convenience in catalyst recovery and simplicity in product separation.

The invention provides a substituted amino bipyridine derivative as well as a preparation method and application thereof, the structure of the substituted amino bipyridine derivative is as shown in formula I. In the formula, R1, R2, R3 and R4 are independently selected from any one of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C20 alkynyl, C3-C6 cycloalkyl, C5-C20 aryl or C5-C20 heterocyclic radical; when R1, R2, R3 and R4 are not methyl, no more than one of R1, R2, R3 and R4 is H; and when any one of R1, R2, R3 and R4 is methyl, the rest groups are independently selected from H or methyl. When the substituted amino dipyridyl derivative provided by the invention is used as a blue dye, the dyed blue dye is bright in color, deep in dyeing and comprehensive in dyeing fastness; the preparation process is simple, convenient to purify, safe, simple, convenient and energy-saving, the product quality is stable, the reproducibility is good, the yield is high, and the method is suitable for industrial production.

The invention provides a self-assembled monomolecular layer hole transport material based on a polycarbazole derivative and a preparation method and application thereof, and the self-assembled monomolecular layer hole transport material has a structure as shown in a formula I. The self-assembled monomolecular layer hole transport material is simple in structure, high in hole transport property, strong in interface passivation ability, high in thermal stability, and suitable for large-scale application; a polycarbazole derivative is taken as a mother nucleus, an alkyl / aryl chain is taken as a linking group, phosphoric acid is taken as an anchoring group, and rigid conjugated large-plane polycarbazole with a specific structure is taken as the mother nucleus, so that molecular accumulation can be improved, and the hole transport performance of the material can be improved. By taking a phosphate group as a tail end, single-molecule self-assembly can be realized, a perovskite interface can be passivated, the energy loss at the interface is reduced, and the battery performance is improved.

IR-sensitive lithographic printing plate precursors provide a stable print-out image using a unique IR radiation-sensitive composition in an infrared radiation-sensitive image-recording layer. This IR radiation-sensitive composition includes: (1) a free radical initiator composition that comprises an electron-donating agent; (2) a free radically polymerizable composition; and (3) a color-changing compound that is represented by the Structure (I) having a conjugated carbon chain between the aromatic terminal groups. The compound also has a —SO2—R3 group wherein R3 represents alkyl, aryl or heteroaryl groups. After IR imaging, these precursors exhibit desirable printout images both fresh and after dark storage. The precursors can be developed off-press or on-press.

A polyfunctional organohydrogensiloxane is prepared using a fluorinated triarylborane Lewis acid as catalyst. The polyfunctional organohydrogensiloxane may be formulated into release coating compositions. Alternatively, the polyfunctional organohydrogensiloxane may be further functionalized with a curable group to form a clustered functional organosiloxane. The clustered functional organosiloxane may be formulated into thermal radical cure adhesive compositions.

Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 1-723.

The invention relates to a compound, a composition, an organic optoelectronic device, and a display device. The compound is represented by Chemical Formula 1, where X1 and X2 are each independently NRa, O, S, Se, or Te, any one of R1 to R10 is a group represented by Chemical Formula A, the remaining ones of R1 to R10 and Ra are each independently hydrogen, deuterium, a substituted or unsubstituted C1 to C20 alkyl group, a substituted or unsubstituted C6 to C30 aryl group, a substituted or unsubstituted C2 to C30 heterocyclic group, a substituted or unsubstituted amine group, a substituted or unsubstituted silyl group, a cyano group, or a halogen, and R1 to R10 and Ra are each independently present, or adjacent two of R1 to R10 and Ra are linked to form a ring.

The invention belongs to the technical field of pesticides, and particularly relates to a mesoionic pyrimidinium compound, and an N-oxide or salt and application thereof. The compound is shown as a general formula I, wherein Q1 and Q2 respectively and independently represent O or S; x represents a cyano group, a cyano alkyl group, an aryl group or a heterocyclic group; y1 is halogen; y2 and Y3 each independently represent hydrogen, halogen, alkyl, or the like; and Z1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8 independently represent hydrogen, halogen, cyano, nitro, alkyl and the like. The compound has an excellent prevention and treatment effect on pests such as spodoptera frugiperda, armyworm and prodenia litura.

A photocurable silicone composition is disclosed. A cured product of the composition is also disclosed. The photocurable silicone composition comprises: (A) an organopolysiloxane having at least one aryl group with 6 to 12 carbons and at least one alkenyl group with 2 to 12 carbons in a molecule; (B) an organic compound having at least two ether bonds and at least one aliphatic carbon-carbon double bond in a molecule; (C) a thiol group-containing organic compound comprising; (C1) an organic compound having two thiol groups in a molecule, and (C2) an organic compound having at least three thiol groups in a molecule; and (D) a photoradical initiator. The composition generally suppresses crack and delamination of a cured product laminated between two substrates after thermal aging.

The invention provides a method for arylation and cyclization of polypeptide, and the reaction process is as follows: the specific method comprises the following steps: under weakly acidic, neutral or weakly alkaline conditions, carrying out a chemical selective arylation reaction on linear polypeptide II containing two cysteine residues through a dichloro nitrogen-containing heteroaromatic ring reagent I, so as to construct a cyclized stable polypeptide III. The cyclized stable polypeptide III has improved stability and cell transmembrane properties under physiological conditions.

The invention provides an anion exchange polymer and a preparation method thereof and an anion exchange membrane, the anion exchange polymer comprises a chain segment I and / or a chain segment II, the structural formula of the chain segment I is # imgabs0 #, the structural formula of the chain segment II is # imgabs1 #, A is nitrogen-containing heterocyclic ketone, Ar1 is a first aryl structural unit, Ar2 is a second aryl structural unit, and the structural formula of the chain segment II is # imgabs1 #. M <-> is a trifluoroacetic acid ion and / or a p-toluenesulfonate ion. The anion exchange polymer disclosed by the invention is relatively low in toxicity to a catalyst, so that the anion exchange polymer shows excellent electrochemical performance.

A polysubstituted aryl compound as shown in formula (I) or a stereoisomer thereof or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a use of the polysubstituted aryl compound or the stereoisomer thereof or the pharmaceutically acceptable salt thereof as an NMT (N-myristoyltransferase) inhibitor in the prevention or treatment of NMT-related diseases.

The invention belongs to the field of polymer synthesis, and particularly discloses a composite catalyst and application thereof. The composite catalyst comprises a main catalyst and a cocatalyst, the chemical formula of the main catalyst is RTiX3, and R is acenaphthenyl and acenaphthenyl containing substituent groups; x is independently selected from any one of a halogen atom, a C1-8 alkyl group, a C2-8 alkenyl group, a C3-8 alkene alkyl group, a C1-8 alkoxy group, an aryl group, a C7-10 aralkyl group and a C7-10 alkaryl group; the co-catalyst comprises an aluminum alkyl catalyst and a silane catalyst. The composite catalyst provided by the invention can significantly improve the conversion rate of styrene, replaces a conventional catalyst system with high aluminum content, and reduces the aluminum content in a styrene polymerization product; the purposes of greatly improving the production efficiency and reducing the production cost are achieved by the post-treatment process of aluminum removal and purification without further solution washing of the styrene polymerization product.