The invention relates to application of a compound in preparation of a
medicine for treating related diseases and / or symptoms caused by new
coronavirus infection. The compound has efficient activity of inhibiting new
coronavirus infection
in vivo and
in vitro, and is low in
cytotoxicity. Meanwhile, as a host AXL
receptor inhibitor, the SARS-CoV-2 inhibitor blocks the
binding site of the SARS-CoV-2 and the
receptor AXL of the SARS-CoV-2, and as an
interferon inducer, the SARS-CoV-2 inhibitor can strongly up-regulate the expression of I-type
interferon, and double-targeting host
receptor and
interferon pathway can exert strong anti-neocoronavirus activity. Therefore, the compound disclosed by the invention is based on a novel anti-new
coronavirus double-targeting strategy of blocking AXL receptor effect and up-regulating interferon response, is relatively safe to host cells, and can be used for preventing and treating new coronavirus infection.