The invention discloses application of a heterogeneous bluetongue virus double-strand RNA (ribonucleic acid) in the preparation of an inducer as an endogenic interferon. The inducer is prepared by extracting naked dsRNA (double-strand ribonucleic acid) molecules from an animal bluetongue virus, is directly used for a human body, induces the human body to generate the endogenic interferon, and gives an antiviral function, an anticancer function and wide disease prevention and treatment and health invigoration functions to the human body. The application has the main advantages that: (A), the human body is directly induced to generate the ENIs (endogenic interferons) with complete varieties, the in-vivo concentration is high, the antiviral activity and the antitumor activity are strongest, the immunogenicity of a heterogeneous protein is free, the dependence is free, the purification is not necessary, and the manufacturing cost is low; (B), the infectivity is free, the heterogeneous bluetongue virus is a dsRNA virus, the tumor origin is free, the heterogeneous bluetongue virus is a natural virus, and the ecological equilibrium is not influenced; (C), the heterogeneous bluetongue virus is a brand-new natural green biomaterial which is safe to people, is inexhaustible, can be regenerated infinitely, and is convenient for in-vitro proliferation, purification and preparation; and (D), the species specificity is highly accorded, and the pharmacological action in the human body is strongest.