82 results about "Urea derivatives" patented technology

Provided herein are compounds of Formula (l-A) or (l-B) as PI3Ka inhibitors for the treatment of cancer.

The presented invention relates to a method of synthesis of carbon-supported platinum group metal or metal alloy nanoparticles, which comprises the following steps:adsorbing on carbon support complexes of a platinum group metal with a urea complexing agent selected from a group comprising urea, urea derivative, a mixture of urea with at least one urea derivative, and a mixture of at least two urea derivatives; andreducing the complexes adsorbed on the carbon support to metal nanoparticles, forming a product of carbon-supported metal nanoparticles.The invention also provides the use of the carbon-supported platinum group metal or metal alloy nanoparticles obtained by the method of the invention as catalyst.The present invention further relates to a method of adsorption of precursors of platinum group metals on the surface of a carbon support and use of complexes of platinum group metals with urea complexing agent for adsorption of platinum group metal precursors on carbon support.

There is provided a technology capable of controlling the occurrence of “migration” of a foam material to a contact object.The present technology provides a package material containing: a fibrous material that includes waste paper and / or pulp; a binder; sodium hydrogen carbonate; a surfactant; and a water-soluble softener, the water-soluble softener being a urea derivative having a chemical structural formula of R1,R2—N—CO—N—R3,R4 (R1 to R4 are each H or a saturated and / or unsaturated hydrocarbon group having 1 to 4 carbon atoms) and / or a water-soluble polyhydric alcohol having 3 to 15 carbon atoms, the number of carbon atoms and the number of hydroxyl (OH) groups in a molecular structure of the water-soluble polyhydric alcohol satisfying a relationship of the number of hydroxy groups<the number of carbon atoms.

The invention relates to the technical field of medicines, in particular to fused tricyclic substituted isoxazolidinyl urea derivatives, pharmaceutically acceptable salts, stereoisomers, pharmaceutical compositions and application thereof. The structure of the fused tricyclic substituted isoxazolidinyl urea derivative is as shown in a formula (I). The fused tricyclic substituted isoxazolidinyl urea derivative disclosed by the invention has obvious TrkA kinase and cell inhibition activity and selective inhibition activity.

The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Provided is a compound represented by Formula (I): wherein Ring A is a ring represented by: wherein X is a single bond or the like, R2 is substituted or unsubstituted aromatic carbocyclyl or the like, R3c is substituted or unsubstituted aromatic carbocyclyl or the like, R3 is substituted or unsubstituted aromatic carbocyclyl or the like, R3a is a hydrogen atom or the like, R3b is a hydrogen atom, R8a is substituted or unsubstituted aromatic carbocyclyl or the like, and R8b is a hydrogen atom or the like, R1 is a substituted or unsubstituted aromatic heterocyclyl, m is 0 or the like, R5a is each independently a hydrogen atom or the like, R5b is each independently a hydrogen atom or the like, R6 is cyano or the like, and R7a and R7b are each independently a hydrogen atom or the like, or a pharmaceutically acceptable salt of the compound.

The present invention relates to a cosmetic composition comprising, in a physiologically acceptable medium, 25% to 40% by weight of urea and / or urea derivatives relative to the total weight of the composition; at least one saccharide-free non-emulsifying hydrophilic gelling polymer; at least one scleroglucan gum; the composition containing less than 2% by weight of surfactant relative to the total weight of the composition, preferably less than 1%, even more preferably less than 0.5% or no surfactant at all. It also relates to the use of a cosmetic composition of this kind for skin care, in particular for the skin of the face or body, as well as to a cosmetic skin care method, in particular for the skin of the face or body, involving the application of a cosmetic composition of this kind.

Bisorthohydroxy aromatic urones and their use as curatives and cure accelerators in resin systems particularly epoxy resin systems provide formulations with good outlife, low curing temperatures and desirable glass transition temperatures after curing, they are particularly useful in prepregs used in the production of components for the aerospace and wind turbine industries.

A process for preparing a cyclic urea derivative by reacting an alkylene carbonate and a primary amine in the presence of a metal oxide catalyst to form the cyclic urea derivative.

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

This invention relates to a sprayable hair care product in the form of an oil-in-water emulsion, having a pH value of 3.0 to 7.0 at 20°C, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), water, and a buffer system for stabilizing the pH value, wherein the water content is equal to 60 to 90% by weight, component (A) is provided in an amount of 1.5 to 20% by weight, and components (B) and (C) are provided in a total amount of 1 to 12% by weight. The invention is characterized in that adenosine is provided in an amount of 0.01 to 3% by weight, and urea and / or urea derivatives are provided in a total amount of 1.0 to 25% by weight. This invention also relates to a method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A) such that the formulation contains 1.5 to 20% by weight of the emulsified oil component (A), wherein the average droplet diameter of the oil component (A) (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)) is less than 1 μm. During or after preparation and before mixing with the adenosine solution, the emulsion is brought to a phase transition temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature. This invention also relates to the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp.

The present invention pertains to a process for preparing an isocyanate-containing compound comprising the step of reacting a compound of formula (1) (1) with oxalyl chloride.

The invention relates to a solvent free method for producing chimeric hemicucurbit[n]urils. The method of the invention comprises a first step of contacting, under mechanical agitation, at least two different cyclic urea derivatives and a compound that can form methylene bridges in the presence of an acid and templating anions and a second step of aging the products for at least about 30 minutes. The method has a very low process mass intensity (PMI) of 4, making it very attractive from a green chemistry perspective. New chimeric hemicucurbit[n]urils incorporating D-biotin are also described.

The purpose of the present invention is to provide a method for simultaneously performing concentration and deproteinization of natural rubber latex.　The present invention relates to: a method for concentrating natural rubber latex, the method being characterized by adding a surfactant, urea or a urea derivative, a compound that is selected from the group consisting of hydroxide salts, ammonia and salts thereof, and optionally a polar organic solvent to natural rubber latex, introducing a gas containing at least 0.1-100% by volume of carbon dioxide into the natural rubber latex, leaving the natural rubber latex to stand still so as to separate the natural rubber latex into a cream phase and a serum phase, and recovering the cream phase; and a method for producing a concentrated natural rubber.

Bis-orthohydroxy aromatic urones and their use as curing agents and cure accelerators in resin systems, particularly epoxy resin systems, provide formulations with good longevity, low cure temperatures, and desirable glass transition temperatures after cure, and are particularly useful in prepregs used in the manufacture of parts for the aerospace and wind turbine industries.

The present invention relates to novel compounds for treating, alleviating or preventing diseases, disorders and abnormalities that respond to modulation of NLRP3 inflammasome pathway components or inhibition of their activation. In particular, the inflammasome pathway component is the NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3) inflammasome. More particularly, the compounds of the present invention have the ability to modulate the NLRP3 inflammasome pathway. In addition, the compounds of the present invention are suitable for treating, alleviating or preventing diseases, disorders and abnormalities that respond to modulation, particularly reduction, of IL-1β and / or IL-18 levels. #imgabs0#

To provide an antimicrobial composition which has water solubility and exhibits superior antibacterial effects against Gram-positive bacteria.SOLUTION: An antimicrobial composition of the present disclosure contains a diiodomethane compound (A), a cyclodextrin derivative (B), and a compound (C), wherein the compound (C) includes at least one selected from the group consisting of pyrrolidones, organic acids, terpenes, urea and urea derivatives, alcohols, esters, chelating compounds, antioxidants, surfactants, and thioglycolic acid or salts thereof.SELECTED DRAWING: None

Described herein are novel piperidine urea derivative compounds and pharmaceutical compositions thereof for the treatment of neurodegenerative disorders and diseases mediated by soluble epoxide hydrolases.

A method for producing a carbamic acid salt, including contacting a carbon dioxide-containing mixed gas having a partial pressure of carbon dioxide of 0.001 atm or more and less than 1 atm with an amino group-containing organic compound in the presence of a base in at least one organic solvent selected from the group consisting of an organic solvent having 2 or more and 8 or less carbon atoms, and a method for producing a carbamic acid ester or a urea derivative using the carbamic acid salt.

The present disclosure relates to morphic forms of Compound (A). The present disclosure also relates to processes for the preparation of the morphic forms, the pharmaceutical compositions comprising the morphic forms, and the use thereof, e.g., in the treatment of disorders (e.g., in which inflammasome activity is implicated).

The present invention relates to a cosmetic composition comprising, in a physiologically acceptable medium, 25% to 40% by weight of urea and / or urea derivatives relative to the total weight of the composition; at least one saccharide-free non-emulsifying hydrophilic gelling polymer; at least one scleroglucan gum; the composition containing less than 2% by weight of surfactant relative to the total weight of the composition, preferably less than 1%, even more preferably less than 0.5% or no surfactant at all. It also relates to the use of a cosmetic composition of this kind for skin care, in particular for the skin of the face or body, as well as to a cosmetic skin care method, in particular for the skin of the face or body, involving the application of a cosmetic composition of this kind.

To provide an antimicrobial composition which exhibits superior antibacterial effects against at least one of Gram-positive bacteria and Gram-negative bacteria.SOLUTION: An antimicrobial composition of the present disclosure contains a diiodomethane compound (A) and a compound (B), wherein the compound (B) includes at least one selected from the group consisting of organic acids, terpenes, urea and urea derivatives, alcohols, esters, antioxidants, and surfactants.SELECTED DRAWING: None

The present disclosure relates to methods of preparing Compound No. 10. The present disclosure also relates to compounds being prepared by the methods, the pharmaceutical compositions comprising the compounds, and the use thereof, e.g., in the treatment of disorders (e.g., in which inflammasome activity is implicated).

The object of this invention is to provide a polarizing plate that, when used in an image display device with interlayer filling, exhibits minimal reduction in transmittance under high-temperature conditions and excellent durability, and to provide a method for manufacturing the polarizing plate. Furthermore, another object of this invention is to provide a durable image display device with improved display characteristics under high-temperature conditions. This invention provides a polarizing plate characterized by comprising a polyvinyl alcohol-based resin polarizing element formed by adsorbing and orienting iodine, a layer formed on at least one surface of the polarizing element containing a urea-based compound selected from urea, urea derivatives, thiourea, and thiourea derivatives, and a transparent protective film.

To suppress polyene formation in a polarizer made of a polyvinyl alcohol resin film.SOLUTION: A polarizing plate 100 includes a polarizer 101 in which a dichroic dye is adsorbed and aligned on a polyvinyl alcohol-based resin film, and a protective film 103 laminated on at least one surface of the polarizer 101 via an adhesive layer 102. The adhesive layer 102 contains a urea compound. The polarizer 101 contains a radical scavenger. The urea compound is at least one selected from the group consisting of urea, urea derivatives, thiourea, and thiourea derivatives. The radical scavenger is a hindered amine compound.SELECTED DRAWING: Figure 1

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

Described herein are novel piperidine urea derived compounds and pharmaceutical compositions thereof for the treatment of conditions and diseases mediated by soluble epoxide hydrolases.

The invention relates to an aqueous adhesive composition, comprising a thermosetting resin based on: - at least one aromatic compound A1 comprising at least one aromatic ring bearing at least two functions, one of these functions being an aldehyde or a hydroxymethyl function, the other being an aldehyde or a hydroxymethyl function; - at least one aromatic polyphenol A2 comprising at least one aromatic ring bearing at least two hydroxyl functions in meta positions relative to each other, the two ortho positions of at least one of the hydroxyl functions being unsubstituted; and a compound (III): in which each group R1, R2, R3 independently represents an alkyl, alkenyl, aryl, arylalkyl, alkylaryl, cycloalkyl or hydrogen group, X represents S, O or N-R4 with R4 representing an alkyl, aryl, arylalkyl, alkylaryl, cycloalkyl group or compound (III) is melamine or uracil;with compound (I) having a mass ratio of dry extract of the aqueous adhesive composition ranging from 0.003 to 0.160.;

The present invention relates to the field of biological medicines. Disclosed are N-tetrazolyl aryl urea derivatives, a preparation method therefor, and the use thereof. The present invention has recently discovered the N-tetrazolyl aryl urea derivatives, and further found that the compounds have an antagonistic activity against bradykinin B1 receptor, so that the compounds can be used as novel bradykinin B1 receptor antagonists and can be further used for treating or preventing related diseases caused by abnormal expression of the bradykinin B1 receptor. In particular, the present invention has recently found that N-tetrazolyl aryl urea derivatives have prevention or treatment effects on corona virus disease 2019, pulmonary edema, diabetes complications, allergic conjunctivitis, etc.

A composition can be used for producing a PMMA-based cast polymer with a low styrene content using urea (derivatives) as a formulation constituent, and a hydrophilic inorganic compound as a filler. It is possible to produce PMMA-based cast polymers and mouldings having surprisingly high mechanical stability from the composition.