9 results about "Urea derivatives" patented technology

This invention relates to a sprayable hair care product in the form of an oil-in-water emulsion, having a pH value of 3.0 to 7.0 at 20°C, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), water, and a buffer system for stabilizing the pH value, wherein the water content is equal to 60 to 90% by weight, component (A) is provided in an amount of 1.5 to 20% by weight, and components (B) and (C) are provided in a total amount of 1 to 12% by weight. The invention is characterized in that adenosine is provided in an amount of 0.01 to 3% by weight, and urea and / or urea derivatives are provided in a total amount of 1.0 to 25% by weight. This invention also relates to a method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A) such that the formulation contains 1.5 to 20% by weight of the emulsified oil component (A), wherein the average droplet diameter of the oil component (A) (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)) is less than 1 μm. During or after preparation and before mixing with the adenosine solution, the emulsion is brought to a phase transition temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature. This invention also relates to the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp.

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The present invention relates to a reducing agent, comprising: a sulfinate of formula I, wherein R1 is H or C1-C6 hydrocarbyl, R2 is C1-C6 hydrocarbyl or M', and M and M' are each independently at least one monovalent cation or a combination with at least one multivalent cation; and optionally, urea or a urea derivative. The reducing agent contains essentially no sulfonic acid or sulfonate. In addition, the present invention relates to a preparation method for the reducing agent. The reducing agent can effectively improve the properties of a polymerization product when used for emulsion polymerization and preparation of a water-soluble polymer.

This invention relates to a sprayable hair care product in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), and water, wherein the water content is 60-90% by weight, the content of component (A) is 1.5-20% by weight, and the total content of components (B) and (C) is 1-12% by weight. A key feature of this invention is that the adenosine content is 0.01-3% by weight, and the total content of urea and / or urea derivatives is 1.0-25% by weight. This invention also relates to a method for preparing a sprayable aqueous adenosine formulation, wherein an aqueous adenosine solution is mixed with a finely dispersed emulsion of an oil component (A), the average droplet diameter of which is less than 1 μm (measured using a device based on the principle of semi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)), and the amount of which is such that the formulation contains 1.5 to 20% by weight of the emulsified oil component (A). During or after preparation and before mixing with the adenosine solution, the emulsion is heated to the phase inversion temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature. This invention also relates to a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives and having an ethanol content of less than 18% by weight for use in cosmetic treatments of the skin, particularly the scalp.

The present application relates to aqueous sprayable hair supplements comprising urea and / or urea derivatives in a total amount of 1.0 to 20 wt.-%, and adenosine in an amount of 0.05 to 3 wt.-%, wherein the hair supplements comprise less than 18 wt.-%, preferably at most 10 wt.-%, in particular at most 5 wt.-%, of ethanol; and the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18 wt.-% for cosmetic treatment of the skin, in particular the scalp.

The present invention relates to an aqueous, sprayable hair tonic having a pH value of 3.0 to 7.0 at 20°C, comprising urea and / or urea derivatives in a total amount of 1.0 to 20% by weight, adenosine in an amount of 0.05 to 3% by weight, and a buffer system for stabilizing the pH value, wherein the hair tonic comprises less than 18% by weight, preferably not more than 10% by weight, in particular not more than 5% by weight of ethanol; and the use of a sprayable aqueous preparation containing adenosine and urea and / or urea derivatives having an ethanol content of less than 18% by weight for cosmetic treatment of the skin, in particular the scalp.

The present invention aims to provide a urea derivative having excellent gelling ability, a gelling agent containing the urea derivative as an active ingredient, a cosmetic composition containing the gelling agent, and a method for efficiently producing the urea derivative. [Solution] The urea derivative according to the present invention is characterized by being represented by the following formula (I). TIFF2026112244000006.tif39105 [In the formula, R 1 is C 6-20 This represents an aliphatic hydrocarbon group, where n is an integer between 1 and 6.

The present invention relates to the field of biological medicines. Disclosed are N-tetrazolyl aryl urea derivatives, a preparation method therefor, and the use thereof. The present invention has recently discovered the N-tetrazolyl aryl urea derivatives, and further found that the compounds have an antagonistic activity against bradykinin B1 receptor, so that the compounds can be used as novel bradykinin B1 receptor antagonists and can be further used for treating or preventing related diseases caused by abnormal expression of the bradykinin B1 receptor. In particular, the present invention has recently found that N-tetrazolyl aryl urea derivatives have prevention or treatment effects on corona virus disease 2019, pulmonary edema, diabetes complications, allergic conjunctivitis, etc.