181 results about "Tetrazole" patented technology

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

The invention relates to the technical field of pesticide residue detection, and discloses a method and a device for detecting the residual quantity of tetratolfenpyrad and metabolite thereof, and the method for detecting the residual quantity of tetratolfenpyrad and metabolite thereof comprises the following steps: step 1, dissolving a sample of tetratolfenpyrad and metabolite thereof in an extraction solvent; then injecting the extracting solution into a solvent bottle on a liquid chromatograph; and secondly, the inserting part is inserted into a bottle head at the top of the solvent bottle, the inserting part is in butt joint with a straight pipe fitting in the solvent bottle, a second magnetic ring on the inserting part is in magnetic connection with a first magnetic ring on the bottle head, then a first liquid conveying pipe on the inserting part is in butt joint with a butt joint part on the hollow block, and assembly of a section of pipeline structure is completed. Through segmented assembly of the liquid conveying pipeline, magnetic ring limiting and branch pipe fitting design, the pipeline connection stability is effectively enhanced, leakage is avoided, it is ensured that a chromatographic analysis experiment is continuously and accurately carried out, the experiment failure risk is reduced, and solvent waste and environmental pollution are reduced.

The invention belongs to the technical field of sensors, and relates to an array sensor based on cerium-based metal organic framework nano-enzyme and detection application of perfluoroalkyl compounds. The array sensor is a Ce-MOF triple enzyme activity array sensor and is provided with a plurality of mutually independent sensing channels; the sensing channel contains a Ce-MOF nano enzyme and a chromogenic substrate; the chromogenic substrates comprise a first chromogenic substrate, a second chromogenic substrate and a third chromogenic substrate, the first chromogenic substrate comprises 3, 3 ', 5, 5'-tetramethyl benzidine, the second chromogenic substrate comprises 2, 4-diaminophenol and 4-aminoantipyrine, and the third chromogenic substrate comprises xanthine, purine oxidase and nitrogen blue tetrazole. The MOF nano-enzyme array sensor constructed by the invention has relatively high sensitivity and selectivity in identification and distinguishing of PFASs compounds, not only can accurately distinguish single PFASs compounds, but also can perform quantitative detection, and has good response to PFASs with different concentrations.

The invention provides a preparation method of ultrahigh-purity copper. The preparation method comprises the following steps: providing a first anode, a first cathode and an electrolyte; the electrolyte comprises the following components: a purified copper salt solution, inorganic acid, an oxidizing agent and an additive, the purified copper salt solution comprises purified copper salt and water, the purified copper salt comprises copper sulfate and copper nitrate, and the molar ratio of nitrate to sulfate in the purified copper salt solution is (1.5-9): 1; the additive comprises any one or a combination of at least two of an alcohol compound, polyacrylamide or a tetrazole compound; and the first cathode and the first anode are immersed in the electrolyte for electrochemical deposition, and the ultra-high-purity copper is obtained. The electrolyte composed of the purified copper salt solution, the inorganic acid, the oxidizing agent and the additive is adopted, the proportion of nitrate radicals to sulfate radicals in the purified copper salt solution is controlled, the impurity content of the sulfur element and the silver element in the electrolyte can be controlled, and preparation of the ultra-pure electrolytic copper is achieved.

The invention relates to the technical field of bioengineering, in particular to a penicillin G acylase mutant, polynucleotide, an expression vector and application. The penicillin G acylase mutant is obtained by carrying out site-directed mutagenesis on a wild type penicillin G acylase gene of parent Escherichia coli, and carrying out site-directed mutagenesis on the wild type penicillin G acylase gene to obtain the penicillin G acylase mutant. Phenylalanine (F) at the 24th site of an alpha chain, proline (P) at the 383rd site of a beta chain, threonine (T) at the 384th site of the beta chain, glutamic acid (G) at the 385th site of the beta chain and serine (S) at the 386th site of the beta chain of the penicillin G acylase are introduced and mutated by a whole plasmid PCR (Polymerase Chain Reaction) technology to obtain mutants. When the penicillin G acylase mutant obtained by the invention is used for catalyzing methyl mandelate and 3-(1-methyl-1H-tetrazole-5-yl) thiomethyl-7-aminocephalosporanic acid to synthesize cefamandole, the synthesis activity is improved, and meanwhile, the side reaction rate is greatly reduced.

The invention discloses application of hydrogen-rich water in preparation of a drug for treating Duchenne type muscular dystrophy, and particularly relates to the technical field of medicines.The random control experiment is adopted, homologous c57 mice serve as a normal control group, mdx mice are randomly divided into a model group and a hydrogen-rich water group, and the exercise ability is evaluated through a four-limb holding power test and a rotating bar test; detecting mouse creatine kinase by an enzyme-linked immunosorbent assay; carrying out hematoxylin-eosin, NADH-tetrazole reductase and improved Goori three-color dyeing, and carrying out cytochrome C oxidase, succinate dehydrogenase and SDH-COX combined dyeing to observe the pathological change of the skeletal muscle tissue; the invention discloses that the muscle injury condition of a Duchenne type muscular dystrophy model mouse is improved by the hydrogen-rich water through a mitochondrial protection mechanism, and the hydrogen-rich water has a relatively high application prospect and a relatively high economic value.

The invention relates to an etching liquid composition for a copper-based metal film. The etching liquid composition for the copper-based metal film according to the invention comprises hydrogen peroxide, a hydrogen peroxide stabilizer, tetrazole substituted by amino, tetrazole substituted by (C1-C4) alkyl, an ammonium compound and organic acid containing one carboxyl group.

The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

The invention provides a lead salt modified 5-aminotetrazolyl gas generating agent with low combustion temperature and high combustion rate and a preparation method thereof, the gas generating agent comprises 5-aminotetrazole, strontium nitrate and lead salt, and the mass ratio of the lead salt is 5-10%. According to the invention, the 5-aminotetrazolyl gas generating agent is modified, so that the temperature of the gas generating agent can be reduced, the burning speed can be improved, and the applicability of the gas generating agent as a solid propelling type fire extinguishing device is enhanced.

The invention provides an energetic complex K-BTE and a continuous preparation method and application thereof.The continuous preparation method comprises the steps that 1, 2-bis (tetrazole-5-yl) ethane serves as an initial raw material, a ligand solution and a metal ion salt solution are continuously injected into a continuous flow reaction unit through an injection pump, and energetic complex crystals are obtained through filtering, washing and drying; a novel energetic complex preparation method which is simple and continuous in process and mild in reaction condition is developed, the energetic complex K-BTE which is novel in structure and excellent in comprehensive performance is prepared for the first time, and the energetic complex K-BTE has the characteristic of high thermal stability and also has the advantages of being simple and efficient in process method and safe and controllable in process; the thermal decomposition temperature of K-BTE reaches up to 366.5 DEG C, the actually measured impact sensitivity is greater than 40J, the friction sensitivity is between 240N and 360N, and meanwhile, the thermal decomposition of ammonium perchlorate is catalyzed. Due to the excellent performance of the K-BTE, the K-BTE has huge application potential in the field of catalyzing the combustion efficiency of solid propellants as an energetic complex.

The invention discloses a supramolecular self-assembled fiber as well as a preparation method and application thereof in cells. The supramolecular self-assembled fiber is obtained by mixing a cis, cis-cyclohexane-1, 3, 5-triformyl hydrazine mother solution, a p-formylphenylboronic acid mother solution and a 5-(2-aminophenyl) tetrazole mother solution in a phosphate buffer solution; the application of the supramolecular self-assembled fiber in cells comprises the following steps: inoculating a pore plate with Haila cells, gently and horizontally shaking, culturing, washing, incubating in a complete DMEM (Dulbecco Modified Eagle Medium) solution of 5-(2-aminophenyl) tetrazole, and washing to obtain pretreated cells; and further incubating and washing the pretreated cells in a complete DMEM (dulbecco's modified eagle medium) solution containing cis, cis-cyclohexane-1, 3, 5-triformyl hydrazine and p-formylphenylboronic acid, so as to obtain the cells enriched with the boron element. Compared with a small molecular boron carrying agent, the supramolecular self-assembled fiber prepared by the invention realizes effective boron element enrichment, and has the advantages of high affinity to tumor cells, good stability and low biotoxicity.

The present application relates to a kind of phenyl-tetrazole oxime derivatives and its preparation method and application, wherein the phenyl-tetrazole oxime derivatives have the structure as shown in formula (I), wherein R 1 , R 2 , T, R a , R b , R c , R d , R e Have the meaning described in the present application;The phenyl-tetrazole oxime derivatives described in the present application have excellent prevention effect on cucumber downy mildew, rice sheath blight, cucumber gray mold, cucumber powdery mildew and the like, and can be further developed as a fungicide for application.

This invention discloses a method for synthesizing cefotiam, using 7-aminocephalosporanic acid (7-ACA) as the parent nucleus and introducing a 4-dimethylaminopyridine-dimethyl carbonate composite catalytic system. The reaction is carried out in a one-pot process involving 3-position nucleophilic substitution, 7-position amidation, and simultaneous deprotection in a green mixed solvent of ionic liquid [BMIM]BF₄-water with 1-(2-dimethylaminoethyl)-1H-5-mercapto-tetrazole and compound I. This method simplifies the process, improves selectivity, produces a high-purity product with stable yield, and is suitable for industrial production.

The present invention relates to a composition ("TSP-DNA Oligo") comprising: a thermostable peptide ("TSP"), wherein the peptide comprises: an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2 or SEQ ID NO: 3 or SEQ ID NO: 4, or an amino acid sequence with at least about 92% sequence identity to a sequence as set forth in SEQ ID NO; 1, or SEQ ID NO: 2, or SEQ ID NO: 3 or SEQ ID NO: 4; and a "DNA Oligo" linked to the thermostable peptide through a linker, wherein the linker comprises: an azide group, an alkyne group, an isocyanate group, or a tetrazole group; wherein the "DNA oligo" comprises a promoter sequence for a T7, T3, SP6 RNA polymerase, or a known variant of said promoter sequence, or a sequence complementary to said promoter sequence or said variant.

The invention relates to the technical field of energetic material synthesis, and particularly provides 5, 5 '-azotetrazole salt and a preparation method thereof.The preparation method comprises the following steps that 1, pretreated carbon cloth is immersed in a mixed solution formed by dissolving cobalt nitrate hexahydrate, ammonium fluoride and urea in deionized water, after a hydrothermal reaction, the carbon cloth is taken out and calcined in the air atmosphere, and a precursor is obtained; and finally, the cobaltosic oxide electrode material loaded on the carbon cloth is prepared. 2, dissolving 5-aminotetrazole in an alkaline solution to prepare an electrolyte, forming a three-electrode system by taking the electrolyte and cobaltosic oxide loaded on carbon cloth as a working electrode, a platinum sheet as a counter electrode and a mercury / mercuric oxide electrode as a reference electrode, and electrifying to carry out electrochemical reaction; 3, bromine water is dropwise added into the three-electrode system in the electrifying electrolysis process, hydrochloric acid is dropwise added to adjust the pH value after the reaction is finished, extraction and rotary evaporation are conducted, and the final product 5, 5 '-azotetrazole salt is obtained.

The invention discloses DNA (deoxyribonucleic acid) coupled non-natural amino acid as well as a synthesis method and application thereof. The synthesis method of the DNA coupled non-natural amino acid comprises the following steps: adding inorganic alkali and 2, 5-dibromohexane diamide into a boric acid buffer solution containing DNA coupled cysteine as shown in a general formula (I) in the specification, adding an organic phase, and reacting at 25-37 DEG C to enable the DNA coupled cysteine to be subjected to desulfurization elimination, thereby obtaining the DNA coupled non-natural amino acid. DNA coupling dehydroalanine shown as a general formula (II) in the specification is obtained; the method comprises the following steps: carrying out nucleophilic addition reaction on DNA coupled dehydroalanine and a nucleophilic reagent under an alkaline condition or carrying out dipolar cycloaddition reaction on DNA coupled dehydroalanine and 2, 5-substituted tetrazole under an ultraviolet condition to obtain the DNA coupled unnatural amino acid. By adopting the method, the integrity of the DNA chain can be effectively ensured, no by-product is generated in the reaction, and a more powerful chemical tool is provided for construction and subsequent modification of a DNA coding molecular library.

The present invention provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1) and are thus useful in the treatment of diseases that can be treated by inhibition of TRPA1. Pharmaceutical compositions containing the compounds and methods of making the compounds are also provided.

The present invention provides a fungicidal combination comprising (i) an amount of a compound of formula (I) and (ii) an amount of at least one fungicide (A) selected from the group consisting of benzoylanilides, carbamates, conazole, oxazoles, picolinamides, pyrazolecarboxamides, pyridazines, pyridines, quinolines, tetrazoles, thiazoles, chloroindolehydrazide and tiazinone.

The invention provides a polymer compatilizer and application thereof, and relates to the technical field of organic materials. Specifically, a molecular chain of the polymer compatilizer comprises a polyolefin chain segment, a reversible covalent bond group and an active functional group which are connected in sequence; wherein the reversible covalent bond group comprises at least one of a cycloaddition reaction system, a disulfide bond system, a borate bond system, an acylhydrazone bond system, an oxime bond system, a trithiocarbonate bond system and a tetrazole-olefin light click chemical system. According to the compatilizer structure, a dynamic covalent cross-linked network can be constructed at the interface of the composite material, and the interface is endowed with an intelligent response characteristic through fracture and recombination of reversible covalent bonds, so that the interface bonding strength of the composite material is far higher than that of a traditional system; the technical problems that in the material service process in a traditional system, due to permanent covalent bonding, an interface is prone to being damaged and cannot be reversibly repaired are effectively solved.

The invention discloses a method for preparing a lithium battery by using a dual-channel crystalline framework composite quasi-solid electrolyte. The preparation method comprises the following steps: firstly, preparing a zinc-based tetrazole biphenyl dicarboxylic acid metal organic framework material by adopting a solvothermal method, blending the zinc-based tetrazole biphenyl dicarboxylic acid metal organic framework material with a polymer, and then obtaining the metal organic framework composite polymer lithium ion battery electrolyte material by adopting an electrostatic spinning technology. The preparation method comprises the following steps: dissolving butyl acrylate and lithium salt in a mixed solvent of ethylene carbonate, diethyl carbonate and fluoroethylene carbonate, adding a thermal initiator to obtain a gel polyelectrolyte precursor, assembling a lithium ion battery by using the diaphragm material, and heating to generate in-situ polymerization inside the battery. Under the room temperature condition, after the prepared battery is circulated for 60 circles under the rated capacitance of 0.2 C, the specific discharge capacity is 158 mAh / g, and the coulombic efficiency is kept at about 99%; the interface stability is good in a cold environment; the preparation process is low in energy consumption, low in cost and suitable for large-scale industrial production.

Substituted tetrazoles of formula I-a, I-b, or I-c:or a pharmaceutically acceptable salt, deuteroisotope, stereoisomer or tautomer thereof; useful as ACSS2 inhibitors are provided.

The invention relates to the field of medicine, in particular to a preparation method of biphenyl tetrazole derivatives and application of the biphenyl tetrazole derivatives in preparation, prevention or treatment of neurodegenerative diseases and related diseases caused by plateau hypoxia, and the structure of the biphenyl tetrazole derivatives is shown as a formula 8 X in the specification, and R3 is selected from hydrogen, fluorine, chlorine, iodine, methyl, methoxyl, dimethylamino, trifluoromethyl, hydroxyl, carboxyl, nitryl, methoxycarbonyl, acrylate and acrylamide. The biphenyl tetrazole derivative prepared in the invention can destroy Nrf2-Keap1 protein-protein interaction (PPI), and has a very good protection effect on tested cell models of hydrogen peroxide and 6-hydroxydopamine nerve injury and cobalt chloride hypoxia injury. Experimental data show that the biphenyl tetrazole derivative disclosed by the invention is a potential therapeutic molecule, and a certain basis is provided for research and development of drugs.

The invention discloses a method for synthesizing carbamic acid-(R)-1-aryl-2-tetrazolyl-ethyl ester on the basis of a continuous flow technology. Specifically, the invention provides a preparation method of a compound 2. The method comprises the following steps: step 1, in a continuous flow reactor, in the presence of a solvent, reacting a compound 1 with chlorosulfonyl isocyanate to obtain a reaction solution; and 2, adding water into the reaction liquid in the step 1 to prepare a corresponding compound 2. The preparation method is simple to operate, high in yield and purity, low in cost and suitable for industrial production.

Provided are a method for processing a semiconductor substrate, a method for manufacturing a semiconductor device, and a processing solution for a semiconductor device usable therefor, in which: a processing step of processing a semiconductor substrate including a layer containing a metal nitride with a processing solution for a semiconductor device is included; the processing solution for a semiconductor device contains NH3, a corrosion inhibitor, and water; the corrosion inhibitor is at least one selected from the group consisting of 5-methyl-1H-benzotriazole, imidazole, and 5-amino-1H-tetrazole; and a mass ratio of a content of NH3 to a content of the corrosion inhibitor (NH3 / corrosion inhibitor) is 5 to 60.

The invention discloses a compound etching additive as well as a preparation method and application thereof, and the compound etching additive is prepared from 5-aminotetrazole, 3, 5-diamino-1, 2, 4-triazole, glucomannan, triethanolamine, ethylenediamine tetraacetic acid tetrasodium salt, diethylene glycol monoethyl ether, sodium p-hydroxybenzenesulfonate and ultrapure water. The compound etching additive disclosed by the invention has the advantages that the hydrogen peroxide is not cracked under the conditions of high temperature and low temperature for organic acid, inorganic acid and hydrogen peroxide and organic alkali and inorganic alkali and hydrogen peroxide system titanium etching liquid, so that attack and corrosion of liquid medicine to silicon nitride, silicon oxide, aluminum nitride, aluminum oxide, stainless steel and copper metal are inhibited; the corrosion rate can be greatly reduced, even part of materials are not corroded, the etching effect of the liquid medicine on the titanium layer is not affected, and the beneficial effects of improving the titanium etching rate and prolonging the service life of the bath solution are achieved.

The invention relates to the technical field of material synthesis, and provides a hydrogen bond organic framework material, a synthesis method and application. The hydrogen bond organic framework material is structurally characterized in that an organic ligand 1, 3, 5-tri (1H-tetrazole-5-yl) benzene is connected with six water molecules and two adjacent organic ligand 1, 3, 5-tri (1H-tetrazole-5-yl) benzene through hydrogen bonds to form a layered network structure; chloride ions are chelated in pore channels of the layered network structure; and the layers are stacked in parallel. Organic molecules are connected through hydrogen bonds, halogen chloride ions are chelated in pore channels, the fluorescent probe type hydrogen bond organic framework material is synthesized, and fluorescence enhanced response of the hydrogen bond organic framework material to heavy metal lead ions in water is achieved.

A protective-film forming composition against a semiconductor wet etching solution, containing: component (A): a film-forming component; component (B): at least one of a triazole compound (B-1), a tetrazole compound (B-2), a compound (B-3) having two or more phenolic hydroxy groups, and a compound (B-4) having two or more non-phenolic hydroxy groups; and component (C): a solvent.

The application discloses a zinc metal organic framework material and a preparation method and application thereof, and relates to the technical field of energy materials.The application provides a preparation method of a zinc metal organic framework material, wherein a soluble zinc salt is used as a zinc source, dimethyl imidazole and pentaamino tetrazole are used as ligands, and a liquid phase reaction is performed to obtain the zinc metal organic framework material.A coating material based on the zinc metal organic framework material can protect a zinc negative electrode of a zinc ion battery, and can reduce irreversible consumption of the zinc negative electrode and electrolyte during battery cycle, thereby significantly delaying battery performance degradation.

The invention discloses a medical antibacterial controlled-release hydrogel and a preparation method thereof, the medical antibacterial controlled-release hydrogel comprises sericin-polyethylene glycol-tetrazole, norbornene-hyaluronic acid and norbornene-polylysine, and the medical antibacterial controlled-release hydrogel is prepared from sericin-polyethylene glycol-tetrazole, norbornene-hyaluronic acid and norbornene-polylysine, the mass ratio of the sericin-polyethylene glycol-tetrazole to the norbornene-hyaluronic acid to the norbornene-polylysine is 1 to (1.0 to 3.5) to (0.1 to 1.7). The hydrogel comprises the following components: sericin-polyethylene glycol-tetrazole, norbornene-hyaluronic acid, norbornene-polylysine, sodium alginate, sodium alginate and sodium alginate. A compact and uniformly distributed covalent network is formed by tetrazole sites in sericin-polyethylene glycol-tetrazole and double bonds of norbornene in norbornene-hyaluronic acid and norbornene-polylysine, and the hydrogel with excellent stability, adhesion performance, toughness, antibacterial performance and slow release performance is prepared through the synergistic effect of the three components.