119 results about "Benzoxazole" patented technology

The invention provides a low-smoke halogen-free flame-retardant cable material and a preparation method thereof, and belongs to the field of cable materials. The low-smoke halogen-free flame-retardant cable material is prepared from the following chemical components: 32 to 40 parts of nitrile rubber, 22 to 27 parts of natural rubber, 8 to 12 parts of benzoxazole-siloxane copolymer containing phosphate dynamic bonds, 13 to 15 parts of core-shell-sheath three-stage structure flame retardant, 4 to 6 parts of hexaphenoxy cyclotriphosphazene modified carbon nanotubes, 2 to 3 parts of europium-doped mesoporous cerium dioxide and 3 to 4 parts of nano zinc oxide. The composite material is prepared from the following components in parts by weight: 3 to 4 parts of carbon nanotube grafted montmorillonite hybrid, 2 to 3 parts of lubricant, 0.8 to 1.2 parts of cross-linking agent, 0.3 to 0.4 part of accelerant, 0.4 to 0.6 part of dicumyl peroxide and 0.1 to 0.2 part of antioxidant. Unification of high flame retardance, low smoke, excellent mechanical property and processability of the cable material is realized.

Formula (I): JPEG2025536322000043.jpg74140 (in the formula, L, R 1 , R 2 , R 3 and W is as defined in the specification. and their enantiomers, diastereomers, racemates, tautomers, prodrugs, hydrates, solvates and pharmaceutically acceptable salts are useful in the treatment of diseases and conditions affected by the inhibition of Mer kinase, such as cancer.

The present application provides a compound containing hydroxyl triarylamine, which can be used as a light extraction material, and its structure is shown in formula (I). In formula (I), hydroxyl groups and benzoxazole or benzothiazole are introduced into the triarylamine main structure of the traditional light extraction layer material. The hydrogen atoms in the hydroxyl group can form intramolecular hydrogen bonds with the heteroatoms on benzoxazole or benzothiazole, thereby improving the planarity of the molecule and increasing the packing density between molecules. At the same time, this intramolecular hydrogen bond undergoes intramolecular proton transfer under light conditions to form a resonance structure. This process converts ultraviolet light energy into heat energy release instead of material deterioration caused by photochemical reactions, thereby reducing the damage caused by ultraviolet light to the device. In addition, the raw materials of the compound are easy to obtain, and it has higher economic value while ensuring good device protection function. The present application also provides an organic electroluminescent device and a display device. #imgabs0#

The invention discloses an iron-loaded sulfonated carbon nitride heterogeneous catalyst as well as a preparation method and application thereof, and belongs to the field of heterogeneous catalysts. The iron-loaded sulfonated carbon nitride heterogeneous catalyst consists of monatomic Fe and a sulfonated graphite phase carbon nitride carrier, so that the prepared iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the reaction of benzoxazole and absolute ethyl alcohol, is high in catalytic efficiency, can catalyze the reaction of benzimidazole or benzothiazole and absolute ethyl alcohol, and is high in catalytic efficiency. Therefore, 2-(1-hydroxyethyl)-benzimidazole or 2-(1-hydroxyethyl)-benzothiazole is synthesized, and concentrated acid does not need to be used as a catalyst in the synthesis process. The sulfonation degree of the iron-loaded sulfonated carbon nitride heterogeneous catalyst can be regulated and controlled, the iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the construction of a directional C-C bond, and the iron-loaded sulfonated carbon nitride heterogeneous catalyst keeps stable in the reaction process and can be recycled for 5 times or more.

The application relates to a quality inspection technology of inorganic salt, and discloses a detection reagent and a rapid detection method for high-purity lithium carbonate. A water-soluble fluorescent probe detection reagent is obtained by using 2-(4-chlorophenyl) benzoxazole, 2-(2-hydroxyphenyl) benzoxazole and other benzoxazole compounds as a substrate, and by modifying the substrate with glycerol, tris(hydroxyl) aminomethane and other compounds; high-purity lithium carbonate is detected by using the detection reagent; the high-purity lithium carbonate is solid-phase prepared into lithium carbonate suspension liquid; the upper liquid phase of the lithium carbonate suspension liquid is taken; the fluorescent probe detection reagent is added into the upper liquid phase; and the high-purity lithium carbonate is rapidly detected according to the fluorescent spectrum and a working curve. The application can realize the rapid detection of the high-purity lithium carbonate in a water-soluble environment, and the detection response time can be as short as 3-10 seconds.

The invention relates to the technical field of waterproof coiled materials, in particular to an anti-ultraviolet SBS waterproof coiled material and a preparation method thereof.The waterproof coiled material comprises a base layer, an anti-ultraviolet SBS asphalt layer and a thin film layer, the anti-ultraviolet SBS asphalt layer comprises asphalt, an SBS elastomer, asphalt softening oil, an anti-aging waterproof multifunctional agent, composite filler, an initiator and the like, and the thin film layer is prepared from the following components; the anti-aging waterproof multifunctional agent prepared by the invention takes macromolecular polysiloxane as a main chain and simultaneously contains a double hindered amine structure and a benzoxazole structure, and the benzoxazole structure not only can cooperate with a polysiloxane structure to improve the thermal aging resistance of a material, but also can endow a coiled material with a rigid structure; the double hindered amine structure has better ultraviolet aging resistance and does not influence the improvement of silicon-oxygen bonds on the waterproof performance of the coiled material, and the functional agent can make the asphalt coiled material become a coiled material resistant to thermal aging, ultraviolet aging and chemical substance erosion.

A novel method for artificial photosynthesis utilizing a chemical system that operates by harnessing visible light and directly capturing carbon dioxide and water from the atmosphere. The system is based on self-organizing complexes comprising visible-light-sensitive chromophores, such as 2-phenyl indole and 2-phenyl benzoxazole, along with titanium tetrachloride, which autonomously perform continuous, complex chemical operations to produce long-chain (C2 to C17) oxygenated organic materials. The process employs earth-abundant metal coordination compounds, including titanium (Ti), zirconium (Zr), hafnium (Hf), and vanadium (V), in the solid state. These compounds form carbonated metal derivatives upon hydrolysis, which are subsequently reduced through proton transfer from water. The system initially generates C1 materials that oligomerize via a novel self-catalyzed mechanism intrinsic to the system's operation. Monitoring and characterization of the chemical transformations have been conducted using high-resolution MALDI-TOF (matrix-assisted laser desorption ionization-time of flight) mass spectrometry, supported by infrared (IR) spectroscopy and nuclear magnetic resonance (NMR) analysis. This innovation represents a sustainable and scalable approach for converting atmospheric CO2 into valuable organic materials.

The invention relates to a preparation method of suvorexant, which comprises the following steps: (1) dissolving a compound VIII (R)-4-(5-chlorobenzo [d] oxazole-2-yl)-7-methyl-1, 4-diazacycloheptane-1-carboxylic acid tert-butyl ester in a reaction solvent, adding an acidic reagent at the temperature of 5-15 DEG C, and reacting at the temperature of 25-35 DEG C to prepare a compound IX (R)-5-chloro-2-(5-methyl-1, 4-diazacycloheptane-1-carboxylic acid tert-butyl ester; 2, 4-diazacycloheptane-1-yl) benzo [d] oxazole is used as a raw material; and (2) in an alkaline environment and an aprotic solvent, carrying out acylation nucleophilic reaction on the compound IX and 5-methyl-2-(2H-1, 2, 3-triazole-2-yl) benzoic acid to obtain the suvorexant. According to the preparation method, the obtained product is high in yield, the purity reaches 99.9% or above, and the intermediate product is good in character, few in impurity and suitable for industrial production.

The invention relates to a rectification system for preparing 2-(4-methylphenyl) benzoxazole, and relates to the technical field of rectification. A wall scraping stirring device is additionally arranged in a cone of a rectification kettle, a hydraulic driving scraper is arranged in the cone, static deposition of residues is effectively broken, local overheating scaling is avoided, the uniformity of the residues is improved through forced stirring, and the overall viscosity is reduced; residues attached to the kettle wall can be scraped, and wall sticking and caking are prevented; a kettle bottom auxiliary temperature control system is additionally arranged, high-temperature heat-conducting oil is introduced into a jacket structure of the rectifying kettle, the cone temperature is maintained, accurate control is conducted through an independent temperature controller, it is ensured that the residue temperature is stable, residue carbonization caused by local overheating is prevented, it is ensured that the kettle bottom residue temperature is above a softening flow threshold value, the residue viscosity is reduced, and cooling caking is avoided; in cooperation with the rectifying still, still bottom residues in the cone of the rectifying still are effectively cleaned, continuous and stable operation of a rectifying system is ensured, and the stopping time caused by residue blockage is shortened.

The application discloses a preparation method of a 2-substituted benzoxazole compound, which comprises the following steps: first, a hydroxyphenyl glycine derivative and a Lewis acid are added into an organic solvent according to a molar ratio of 1:0.2, visible light is used for irradiation, stirring is conducted in air at room temperature until a sufficient reaction is achieved, the organic solvent is removed by using reduced pressure distillation, and then column chromatography is adopted to obtain a 2-substituted benzoxazole derivative. The application has the advantages of mild reaction conditions, greenness, low cost and high efficiency.

The present application aims at preventing deterioration inside an organic EL element, greatly improving light extraction efficiency, and providing a compound that absorbs light of wavelengths of 400 nm to 410 nm of sunlight without affecting materials inside the element, and has a high refractive index in the range of wavelengths of 450 nm to 750 nm. The present application is an amine compound that has a high refractive index and a specific benzoxazole ring structure. In an organic EL element having, in at least this order, an anode electrode, a hole transporting layer, a light emitting layer, an electron transporting layer, a cathode electrode, and a cover layer, the cover layer preferably contains the amine compound of the present application that has a specific benzoxazole ring structure.

The present application relates to the technical field of display, in particular to an organic compound and application thereof. The organic compound provided by the present application is connected with arylamine containing a benzoxazole structure by limiting the structure of the parent nucleus of formula (1), and the overall compound shows high stability and high hole transport performance by matching different substituent groups, the matching degree of HOMO and LUMO energy levels and adjacent energy levels is high, and then the carrier mobility of the organic compound with the specific structure is more balanced, so that the organic electroluminescent device containing the organic compound has low driving voltage, high luminous efficiency and long service life.

The present invention relates to benzoxazole and benzothiazole compounds or pharmaceutically acceptable salts thereof which are useful for the treatment of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (Exon19 deletion, L858R and the Del 19 / T790M and L858R / T790M resistance mutation). The compounds of the present invention and salts thereof are useful in the treatment or prevention of different types of cancers. The present invention also relates to methods of preparation for benzoxazole and benzothiazole compounds and pharmaceutically acceptable salts, stereoisomers, prodrugs and solvates thereof; a pharmaceutical composition containing the compounds, pharmaceutically acceptable salts, stereoisomers, prodrugs and / or solvates thereof particularly useful polymorphs of the compounds and salts thereof. The invention also relates to use of the compounds and pharmaceutically acceptable salts, prodrugs, stereoisomers, and solvates thereof in the preparation of a medicament for treating diseases associated with various forms of EGFR. The definitions of 'A', 'X', R1, R2, R3, and 'm' are as defined herein. Formula (I)

The invention belongs to the technical field of prevention and control of plant bacterial diseases, and particularly relates to an amide derivative containing benzoxazole sulfone and a preparation method and application thereof.The amide compound containing benzoxazole sulfone has good antibacterial activity on plant pathogenic bacteria of rice bacterial leaf blight, rice bacterial streak and citrus canker, and can be used for preventing and controlling bacterial diseases of plants such as rice bacterial leaf blight, rice bacterial streak and citrus canker. The method has the advantages of simple preparation process, excellent reaction yield and low raw material cost; the structural formula of the derivative is shown as I,

A novel preventive and / or therapeutic agent useful in the prevention and / or treatment of a disease whose symptom is alleviated or improved by the inhibition of myostatin. The present invention relates to an agent for preventing and / or treating a disease whose symptom is alleviated or improved by the inhibition of myostatin, the agent including a therapeutically effective dose of (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof, or a solvate thereof.

Described herein is a small molecule splicing modulator compound that modulates splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

The invention discloses a chiral alpha-aryloxy benzoxazole acetate compound and a synthesis method thereof, and the chiral alpha-aryloxy benzoxazole acetate compound is an optically active compound with a structure as shown in the following formula I, and comprises a stereoisomer with the same chemical general formula. According to the method, a complex formed by a chiral ligand and metal is used as a catalyst, an electrochemical catalysis asymmetric aryloxylation reaction is used as a key step, and the target chiral compound is accurately and efficiently synthesized with high yield and high stereoselectivity. The preparation method is simple, reaction conditions are mild, atom economy is excellent, and the prepared chiral alpha-aryloxy benzoxazole acetate compound has good biological activity potential, can be widely applied to the field of drug intermediate synthesis and has remarkable biomedical practicability and industrial large-scale production prospects.

The present invention discloses a chalcone derivative containing a benzoxazole structure, a preparation method thereof, and an application thereof, and belongs to the field of chemical technology. The present invention uses 1-(4-(3-bromopropyloxy)phenyl)-3-(substituted aromatic)-2-propylene-1-one or 1-(4-(4-bromobutyloxy)phenyl)-3-(substituted aromatic)-2-propylene-1-one to undergo an etherification reaction with benzo[d]oxazole-2-thiol to generate a chalcone derivative containing a benzoxazole structure, the structural formula of which is as follows, wherein n is 3 or 4, and R is any one of a phenyl, a substituted phenyl, a thienyl, or a furyl group. Experimental testing has shown that the derivative has good inhibitory activity against plant bacteria such as rice bacterial blight, melon wilt, and potato soft rot, and can be used as a potential agent for inhibiting plant bacteria.

The present disclosure relates to novel benzoxazole derivatives comprising 4-amino-butanamide and anti-inflammatory use thereof.

The present invention relates to the technical field of compound synthesis, and more specifically, to a compound containing benzothiazole or benzoxazole, a preparation method thereof, and an application thereof. The structural formula of the compound containing benzothiazole or benzoxazole is as follows: wherein Y represents O or S, X represents hydrogen or halogen, and R represents any one of a substituted or unsubstituted C3-C8 cycloalkyl, a substituted or unsubstituted phenyl, a substituted or unsubstituted C1-C10 alkyl, and a substituted or unsubstituted C3-C10 alkenyl. The compound can be used as a soluble epoxide hydrolase inhibitor, thereby having a certain therapeutic effect on diseases caused by soluble epoxide hydrolase disorders.

An object of the present application is to provide an organic EL element having a capping layer composed of a material having the following properties: (1) high light absorption coefficient, (2) high refractive index, (3) good stability of thin film, (4) excellent durability, (5) excellent light resistance, and (6) no absorption in the respective wavelength regions of blue, green, and red. Since the arylamine-based material having a specific structure of the present application is excellent in stability of thin film and durability, an amine compound having a specific benzoxazole ring structure and a high refractive index is selected as a material constituting the capping layer, and an organic EL element using the material having a high absorbance at a wavelength of 400 nm to 410 nm in an absorption spectrum at a concentration of 10 ‑5 mol / L shows good element characteristics.

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.

A calix[4]arenes of the formula (1a),wherein: Y1, Y2, Y3 and Y4 are selected from hydrogen, halogen, NO2, N3, CN, CHO, COOR′, CONR″2, NR2, triazole moiety and C1-C3-alkyl group, the C1-C3-alkyl group being optionally substituted, Z is a heterocyclic moiety which is selected from the group including of imidazole, benzimidazole, benzothiazole, benzoxazole, purine, tetrazine, oxazole, pyrazole and thiazole, the heterocyclic moiety being optionally substituted, R1 and R2 are selected from hydrogen and C1-C8-alkyl, the C1-C8-alkyl group being optionally substituted, n being an integer between 1 and 4, They exhibit high cytotoxicity against cancer cells.

The application belongs to the technical field of light materials, and particularly relates to a method for preparing a self-supporting light material and application. The steps are as follows: mixing and stirring heat-conducting core-shell particles, a prepolymer and a compatibilizer; adding a curing agent and an accelerator, and vacuum defoaming; loading the defoamed mixture into an injection cylinder; injection molding, demolding, and obtaining the self-supporting light material, wherein the heat-conducting core-shell particles comprise TiN@AlN particles in which TiN is coated with AlN, and the prepolymer comprises a prepolymer mixed with benzoxazole and epoxy resin. The self-supporting light material is applied to a chip structure. The material prepared by the application can simultaneously meet the comprehensive requirements of high heat conduction, low expansion and high mechanical performance.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of hydrogen-containing silane mediated benzoxazole derivatives, which comprises the following steps: (2-nitrophenyl) benzoate and analogues thereof as nitro substrates are dissolved in acid liquor with a palladium catalyst, hydrogen-containing silane is slowly injected, reaction is carried out under normal pressure, after the reaction is finished, a reaction product is subjected to post-treatment, and the hydrogen-containing silane mediated benzoxazole derivatives are obtained. Separating and purifying to obtain a target product benzoxazole derivative. The novel synthesis method of benzoxazole and derivatives thereof is adopted, high-pressure hydrogen and inert gas protection required by a traditional hydrogenation method is abandoned, nitro reduction and cyclization are completed in one step, and a safe, economical and environment-compatible synthesis scheme is provided for large-scale production of benzo-azacyclo drug intermediates.

The instant invention relates to the use of a substance with phosphodiesterase-7 inhibitory activity (PDE7 inhibitor), such as spiro[[1,3]oxazolo[5,4f-]quinazoline-9,1′-cyclohexan)-7-one derivatives, as active ingredient in a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of different diseases, syndromes, disease states, or conditions associated with chronic fatigue, exhaustion and / or exertional intolerance using PDE7 inhibitors alone or in combination with other therapeutic agents.

The invention provides a phenyl phosphonic acid bis (o-isocyano-phenol) ester ligand which is prepared by the following steps: in an inert gas atmosphere, mixing a compound benzoxazole with anhydrous tetrahydrofuran, cooling to-95 to-65 DEG C, adding an n-butyllithium solution dissolved in an organic solvent, stirring at-95 to-65 DEG C for 0.5-4 hours, adding diphenylphosphoryl chloride, stirring at room temperature for 8-10 hours, filtering, washing, and drying to obtain the phenyl phosphonic acid bis (o-isocyano-phenol) ester ligand. Carrying out post-treatment on the obtained reaction liquid to obtain a phenyl phosphonic acid bis (o-isocyano phenol) ester ligand; compared with the most common organic dye photosensitizer, the copper-based photosensitizer prepared from the phenyl phosphonic acid bis (o-isocyano-phenol) ester ligand overcomes the defect that the catalytic activity of the organic dye photosensitizer is rapidly reduced under long-term illumination, and in addition, the organic dye photosensitizer is easy to generate an aggregation-induced quenching effect; the photosensitizer disclosed by the invention does not generate an aggregation-induced quenching effect; compared with an iridium complex photosensitizer which is commonly used at present, the cuprous photosensitizer provided by the invention is more environment-friendly.

The application belongs to the technical field of membrane preparation and application, and discloses a method for preparing a benzoxazole-containing polyimide carbon molecular membrane for ethylene / ethane separation. The method introduces a novel diamine monomer containing a benzoxazole structure, and polymerizes to obtain a polyimide polymer precursor containing a benzoxazole structure, thereby avoiding the limited conversion rate of thermal rearrangement to generate a benzoxazole structure, and the fact that the thermal rearrangement process causes the molecular chain to break, and further carbonization treatment causes the polymer structure to collapse and the molecular chain to be densely packed. The benzoxazole-containing polyimide carbon molecular sieve membrane has good permeability due to the ordered arrangement of the oxazole ring and the highly twisted rigid structure in the polymer main chain, and in addition, the good planar orientation and intramolecular Π-Π stacking of the polymer are conducive to the selectivity of ethylene / ethane.

The application discloses a kind of based on chelating phosphine ligand Binuclear cuprous cluster luminescent material and its preparation method, and the sensing application of the material to pyridine and cyclohexylamine VOC;The luminescent material structural formula of the application is (Xantphos) Cu2I2 (4-PBO) 2, wherein Xantphos is electric neutral double phosphine ligand 4,5-bis (diphenylphosphine) -9,9-dimethyl xanthene, and 4-PBO is nitrogen-containing ligand 4- (2-benzoxazole) pyridine;It is prepared by coordination reaction of CuI and ligand by mechanical ball milling;The luminescent intensity of material itself is strong, and can be used as luminescent material;And after the material is placed in pyridine or cyclohexylamine atmosphere, different fluorescence sensing response characteristics of fluorescence enhancement and discoloration and fluorescence quenching are presented soon respectively;The material is easy to prepare, and solubility and stability are very good, and it is also easy to prepare into paper-based load or polymer-doped fluorescent sensing film, and the film also shows the fluorescence sensing performance of quick and selective response and sensitive identification.