73 results about "Benzoxazole" patented technology

The application relates to a quality inspection technology of inorganic salt, and discloses a detection reagent and a rapid detection method for high-purity lithium carbonate. A water-soluble fluorescent probe detection reagent is obtained by using 2-(4-chlorophenyl) benzoxazole, 2-(2-hydroxyphenyl) benzoxazole and other benzoxazole compounds as a substrate, and by modifying the substrate with glycerol, tris(hydroxyl) aminomethane and other compounds; high-purity lithium carbonate is detected by using the detection reagent; the high-purity lithium carbonate is solid-phase prepared into lithium carbonate suspension liquid; the upper liquid phase of the lithium carbonate suspension liquid is taken; the fluorescent probe detection reagent is added into the upper liquid phase; and the high-purity lithium carbonate is rapidly detected according to the fluorescent spectrum and a working curve. The application can realize the rapid detection of the high-purity lithium carbonate in a water-soluble environment, and the detection response time can be as short as 3-10 seconds.

The invention relates to a preparation method of suvorexant, which comprises the following steps: (1) dissolving a compound VIII (R)-4-(5-chlorobenzo [d] oxazole-2-yl)-7-methyl-1, 4-diazacycloheptane-1-carboxylic acid tert-butyl ester in a reaction solvent, adding an acidic reagent at the temperature of 5-15 DEG C, and reacting at the temperature of 25-35 DEG C to prepare a compound IX (R)-5-chloro-2-(5-methyl-1, 4-diazacycloheptane-1-carboxylic acid tert-butyl ester; 2, 4-diazacycloheptane-1-yl) benzo [d] oxazole is used as a raw material; and (2) in an alkaline environment and an aprotic solvent, carrying out acylation nucleophilic reaction on the compound IX and 5-methyl-2-(2H-1, 2, 3-triazole-2-yl) benzoic acid to obtain the suvorexant. According to the preparation method, the obtained product is high in yield, the purity reaches 99.9% or above, and the intermediate product is good in character, few in impurity and suitable for industrial production.

The invention relates to a rectification system for preparing 2-(4-methylphenyl) benzoxazole, and relates to the technical field of rectification. A wall scraping stirring device is additionally arranged in a cone of a rectification kettle, a hydraulic driving scraper is arranged in the cone, static deposition of residues is effectively broken, local overheating scaling is avoided, the uniformity of the residues is improved through forced stirring, and the overall viscosity is reduced; residues attached to the kettle wall can be scraped, and wall sticking and caking are prevented; a kettle bottom auxiliary temperature control system is additionally arranged, high-temperature heat-conducting oil is introduced into a jacket structure of the rectifying kettle, the cone temperature is maintained, accurate control is conducted through an independent temperature controller, it is ensured that the residue temperature is stable, residue carbonization caused by local overheating is prevented, it is ensured that the kettle bottom residue temperature is above a softening flow threshold value, the residue viscosity is reduced, and cooling caking is avoided; in cooperation with the rectifying still, still bottom residues in the cone of the rectifying still are effectively cleaned, continuous and stable operation of a rectifying system is ensured, and the stopping time caused by residue blockage is shortened.

The application discloses a preparation method of a 2-substituted benzoxazole compound, which comprises the following steps: first, a hydroxyphenyl glycine derivative and a Lewis acid are added into an organic solvent according to a molar ratio of 1:0.2, visible light is used for irradiation, stirring is conducted in air at room temperature until a sufficient reaction is achieved, the organic solvent is removed by using reduced pressure distillation, and then column chromatography is adopted to obtain a 2-substituted benzoxazole derivative. The application has the advantages of mild reaction conditions, greenness, low cost and high efficiency.

The present application aims at preventing deterioration inside an organic EL element, greatly improving light extraction efficiency, and providing a compound that absorbs light of wavelengths of 400 nm to 410 nm of sunlight without affecting materials inside the element, and has a high refractive index in the range of wavelengths of 450 nm to 750 nm. The present application is an amine compound that has a high refractive index and a specific benzoxazole ring structure. In an organic EL element having, in at least this order, an anode electrode, a hole transporting layer, a light emitting layer, an electron transporting layer, a cathode electrode, and a cover layer, the cover layer preferably contains the amine compound of the present application that has a specific benzoxazole ring structure.

The present application relates to the technical field of display, in particular to an organic compound and application thereof. The organic compound provided by the present application is connected with arylamine containing a benzoxazole structure by limiting the structure of the parent nucleus of formula (1), and the overall compound shows high stability and high hole transport performance by matching different substituent groups, the matching degree of HOMO and LUMO energy levels and adjacent energy levels is high, and then the carrier mobility of the organic compound with the specific structure is more balanced, so that the organic electroluminescent device containing the organic compound has low driving voltage, high luminous efficiency and long service life.

The present invention relates to benzoxazole and benzothiazole compounds or pharmaceutically acceptable salts thereof which are useful for the treatment of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (Exon19 deletion, L858R and the Del 19 / T790M and L858R / T790M resistance mutation). The compounds of the present invention and salts thereof are useful in the treatment or prevention of different types of cancers. The present invention also relates to methods of preparation for benzoxazole and benzothiazole compounds and pharmaceutically acceptable salts, stereoisomers, prodrugs and solvates thereof; a pharmaceutical composition containing the compounds, pharmaceutically acceptable salts, stereoisomers, prodrugs and / or solvates thereof particularly useful polymorphs of the compounds and salts thereof. The invention also relates to use of the compounds and pharmaceutically acceptable salts, prodrugs, stereoisomers, and solvates thereof in the preparation of a medicament for treating diseases associated with various forms of EGFR. The definitions of 'A', 'X', R1, R2, R3, and 'm' are as defined herein. Formula (I)

A novel preventive and / or therapeutic agent useful in the prevention and / or treatment of a disease whose symptom is alleviated or improved by the inhibition of myostatin. The present invention relates to an agent for preventing and / or treating a disease whose symptom is alleviated or improved by the inhibition of myostatin, the agent including a therapeutically effective dose of (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof, or a solvate thereof.

Described herein is a small molecule splicing modulator compound that modulates splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

The invention discloses a chiral alpha-aryloxy benzoxazole acetate compound and a synthesis method thereof, and the chiral alpha-aryloxy benzoxazole acetate compound is an optically active compound with a structure as shown in the following formula I, and comprises a stereoisomer with the same chemical general formula. According to the method, a complex formed by a chiral ligand and metal is used as a catalyst, an electrochemical catalysis asymmetric aryloxylation reaction is used as a key step, and the target chiral compound is accurately and efficiently synthesized with high yield and high stereoselectivity. The preparation method is simple, reaction conditions are mild, atom economy is excellent, and the prepared chiral alpha-aryloxy benzoxazole acetate compound has good biological activity potential, can be widely applied to the field of drug intermediate synthesis and has remarkable biomedical practicability and industrial large-scale production prospects.

The present disclosure relates to novel benzoxazole derivatives comprising 4-amino-butanamide and anti-inflammatory use thereof.

An object of the present application is to provide an organic EL element having a capping layer composed of a material having the following properties: (1) high light absorption coefficient, (2) high refractive index, (3) good stability of thin film, (4) excellent durability, (5) excellent light resistance, and (6) no absorption in the respective wavelength regions of blue, green, and red. Since the arylamine-based material having a specific structure of the present application is excellent in stability of thin film and durability, an amine compound having a specific benzoxazole ring structure and a high refractive index is selected as a material constituting the capping layer, and an organic EL element using the material having a high absorbance at a wavelength of 400 nm to 410 nm in an absorption spectrum at a concentration of 10 ‑5 mol / L shows good element characteristics.

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.

A calix[4]arenes of the formula (1a),wherein: Y1, Y2, Y3 and Y4 are selected from hydrogen, halogen, NO2, N3, CN, CHO, COOR′, CONR″2, NR2, triazole moiety and C1-C3-alkyl group, the C1-C3-alkyl group being optionally substituted, Z is a heterocyclic moiety which is selected from the group including of imidazole, benzimidazole, benzothiazole, benzoxazole, purine, tetrazine, oxazole, pyrazole and thiazole, the heterocyclic moiety being optionally substituted, R1 and R2 are selected from hydrogen and C1-C8-alkyl, the C1-C8-alkyl group being optionally substituted, n being an integer between 1 and 4, They exhibit high cytotoxicity against cancer cells.

The application belongs to the technical field of light materials, and particularly relates to a method for preparing a self-supporting light material and application. The steps are as follows: mixing and stirring heat-conducting core-shell particles, a prepolymer and a compatibilizer; adding a curing agent and an accelerator, and vacuum defoaming; loading the defoamed mixture into an injection cylinder; injection molding, demolding, and obtaining the self-supporting light material, wherein the heat-conducting core-shell particles comprise TiN@AlN particles in which TiN is coated with AlN, and the prepolymer comprises a prepolymer mixed with benzoxazole and epoxy resin. The self-supporting light material is applied to a chip structure. The material prepared by the application can simultaneously meet the comprehensive requirements of high heat conduction, low expansion and high mechanical performance.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of hydrogen-containing silane mediated benzoxazole derivatives, which comprises the following steps: (2-nitrophenyl) benzoate and analogues thereof as nitro substrates are dissolved in acid liquor with a palladium catalyst, hydrogen-containing silane is slowly injected, reaction is carried out under normal pressure, after the reaction is finished, a reaction product is subjected to post-treatment, and the hydrogen-containing silane mediated benzoxazole derivatives are obtained. Separating and purifying to obtain a target product benzoxazole derivative. The novel synthesis method of benzoxazole and derivatives thereof is adopted, high-pressure hydrogen and inert gas protection required by a traditional hydrogenation method is abandoned, nitro reduction and cyclization are completed in one step, and a safe, economical and environment-compatible synthesis scheme is provided for large-scale production of benzo-azacyclo drug intermediates.

The instant invention relates to the use of a substance with phosphodiesterase-7 inhibitory activity (PDE7 inhibitor), such as spiro[[1,3]oxazolo[5,4f-]quinazoline-9,1′-cyclohexan)-7-one derivatives, as active ingredient in a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of different diseases, syndromes, disease states, or conditions associated with chronic fatigue, exhaustion and / or exertional intolerance using PDE7 inhibitors alone or in combination with other therapeutic agents.

The invention provides a phenyl phosphonic acid bis (o-isocyano-phenol) ester ligand which is prepared by the following steps: in an inert gas atmosphere, mixing a compound benzoxazole with anhydrous tetrahydrofuran, cooling to-95 to-65 DEG C, adding an n-butyllithium solution dissolved in an organic solvent, stirring at-95 to-65 DEG C for 0.5-4 hours, adding diphenylphosphoryl chloride, stirring at room temperature for 8-10 hours, filtering, washing, and drying to obtain the phenyl phosphonic acid bis (o-isocyano-phenol) ester ligand. Carrying out post-treatment on the obtained reaction liquid to obtain a phenyl phosphonic acid bis (o-isocyano phenol) ester ligand; compared with the most common organic dye photosensitizer, the copper-based photosensitizer prepared from the phenyl phosphonic acid bis (o-isocyano-phenol) ester ligand overcomes the defect that the catalytic activity of the organic dye photosensitizer is rapidly reduced under long-term illumination, and in addition, the organic dye photosensitizer is easy to generate an aggregation-induced quenching effect; the photosensitizer disclosed by the invention does not generate an aggregation-induced quenching effect; compared with an iridium complex photosensitizer which is commonly used at present, the cuprous photosensitizer provided by the invention is more environment-friendly.

The application belongs to the technical field of membrane preparation and application, and discloses a method for preparing a benzoxazole-containing polyimide carbon molecular membrane for ethylene / ethane separation. The method introduces a novel diamine monomer containing a benzoxazole structure, and polymerizes to obtain a polyimide polymer precursor containing a benzoxazole structure, thereby avoiding the limited conversion rate of thermal rearrangement to generate a benzoxazole structure, and the fact that the thermal rearrangement process causes the molecular chain to break, and further carbonization treatment causes the polymer structure to collapse and the molecular chain to be densely packed. The benzoxazole-containing polyimide carbon molecular sieve membrane has good permeability due to the ordered arrangement of the oxazole ring and the highly twisted rigid structure in the polymer main chain, and in addition, the good planar orientation and intramolecular Π-Π stacking of the polymer are conducive to the selectivity of ethylene / ethane.

The application discloses a kind of based on chelating phosphine ligand Binuclear cuprous cluster luminescent material and its preparation method, and the sensing application of the material to pyridine and cyclohexylamine VOC;The luminescent material structural formula of the application is (Xantphos) Cu2I2 (4-PBO) 2, wherein Xantphos is electric neutral double phosphine ligand 4,5-bis (diphenylphosphine) -9,9-dimethyl xanthene, and 4-PBO is nitrogen-containing ligand 4- (2-benzoxazole) pyridine;It is prepared by coordination reaction of CuI and ligand by mechanical ball milling;The luminescent intensity of material itself is strong, and can be used as luminescent material;And after the material is placed in pyridine or cyclohexylamine atmosphere, different fluorescence sensing response characteristics of fluorescence enhancement and discoloration and fluorescence quenching are presented soon respectively;The material is easy to prepare, and solubility and stability are very good, and it is also easy to prepare into paper-based load or polymer-doped fluorescent sensing film, and the film also shows the fluorescence sensing performance of quick and selective response and sensitive identification.

The invention belongs to the field of high-frequency communication materials, and particularly discloses a Low-alpha ray spherical alumina / liquid crystal polymer 5G base station substrate material, which is characterized by comprising a liquid crystal copolymer matrix and a Ce < 3 + > doped spherical alumina filler, the liquid crystal copolymer matrix is prepared from three comonomers, namely 60 to 68 mol percent of p-hydroxybenzoic acid, 20 to 24 mol percent of 5, 5 '-dithiobis (2-nitrobenzoic acid) and 12 to 16 mol percent of 4-(5-amino-6-hydroxy-2-benzoxazole)-benzoic acid; the surface of the Ce < 3 + >-doped spherical alumina filler is sequentially coated with a Bi2Te3-xSex topological insulating layer and a phosphate silane grafting layer, wherein x is equal to 0.12-0.18. According to the Low-alpha ray spherical aluminum oxide / liquid crystal polymer 5G base station substrate material, the alpha ray shielding rate is larger than or equal to 99.95%, the heat conductivity is larger than or equal to 3.35 W / mK, the dielectric loss factor tan delta is smaller than 0.00014 under 28 GHz, and the strict requirements for high frequency, high reliability and the like of a substrate in 5G millimeter wave antenna application can be met.

A purpose is to provide a protein crosslinking agent which can be easily used. A protein crosslinking agent for a protein having a β-sheet structure is provided, comprising a structural unit derived from one selected from the group consisting of polyethylene, polyvinyl alcohol, polyamine, polyamide, polyester and polyether, and a group containing an aromatic ring, wherein the group containing an aromatic ring has at least one selected from the group consisting of a benzothiazole group, a benzoxazole group, a benzimidazole group and a naphthylazo group, each of which may have a substituent.

This invention provides a class of short-wavelength light-converting materials based on benzoxazole, with the structure shown in Formula I, where R1 and R2 are each independently hydrogen atoms, C1-C18 straight-chain or branched alkyl groups; and R3 is an aryl group or a substituted aryl group. The short-wavelength light-converting material of this invention possesses advantages such as excellent short-wavelength ultraviolet light absorption, high luminous quantum efficiency, good photostability, low cost, and ease of mass production. When doped at a certain concentration into the encapsulating film of solar cells, it can efficiently absorb short-wavelength ultraviolet light to avoid UVID (ultraviolet-induced power degradation), and convert the absorbed short-wavelength ultraviolet light into long-wavelength ultraviolet or blue-violet light that can be efficiently utilized by solar cells, thereby increasing power generation. This is of great significance for improving the overall performance and economic benefits of photovoltaic modules.

The application belongs to the technical field of membrane preparation and application, and discloses a preparation method of a carbon molecular sieve membrane for efficient separation of ethylene and ethane. The carbon molecular sieve membrane for efficient separation of ethylene and ethane takes polyimide containing a benzoxazole unit as a precursor material, and is carbonized after being doped with sulfur-containing substances to form a film. After carbonization, transition metal silver ions are introduced to form metal coordination complex bonds with sulfur-containing units in the membrane, thereby improving the loading amount of the transition metal silver ions, promoting the transfer of ethylene in the membrane, and improving the separation performance of ethylene and ethane. The application introduces sulfur-containing substances to complex with transition metals, greatly improves the loading amount of the transition metals, and greatly improves the separation effect of ethylene and ethane. The application has a wide application prospect in the field of ethylene and ethane separation.

Provided is an organic electroluminescent (EL) element in which a compound having a high refractive index at a wavelength of 450-750 nm and a low extinction coefficient is used in a coating layer, wherein the light extraction efficiency of the organic EL element is improved. An organic EL element having a positive electrode, a hole transport layer, a light-emitting layer, an electron transport layer, a negative electrode, and a coating layer in this order, the coating layer containing a benzoxazole compound represented by general formula (1) (in the formula, A represents a benzoxazole ring or the like, B and C represent a phenyl group, a naphthyl group, a phenanthroline group, an oxazolopyridyl group or the like, D represents a hydrogen atom, an aryl group or the like, and L1-L3 represent a single bond, a divalent aryl group or the like).

The invention discloses an asymmetric chiral luminescent material based on benzodiazole as well as a preparation method and application thereof, and belongs to the technical field of organic photoelectric semiconductors, the luminescent material is of an asymmetric structure, has better chiral absorption and emission characteristics, and can be applied to the field of organic photoelectric semiconductors. Symmetrical breaking between chromophores in the spiral pi system inhibits electron coupling between excited states. The chiral luminescent material is simple in synthetic route, controllable in energy level, excellent in luminescent behavior and low in cost, has good circularly polarized light (CPL) signal characteristics, and can be widely applied to the fields of chiral filters, polarizers, sensor switches, organic photoelectric devices and the like.

The invention discloses a method for enantioselective synthesis of NH-aziridine, which comprises the following steps: in the presence of a chiral phosphoric acid catalyst, reacting alpha-cyano heterocyclic conjugated olefin as shown in a formula (I) with N-acyloxyhydroxylamine in an organic solvent to obtain NH-aziridine as shown in a formula (II), according to the present invention, the method can be smoothly performed in the inert organic solvent at the temperature of-40-25 DEG C, the substrate can suitably cover pyridine, quinoline, benzimidazole, benzothiazole, benzoxazole and other N-heteroaromatic rings, the product yield is high, and the enantiomeric excess (ee) can be up to 99%. Inorganic additives (such as magnesium oxide) may be optionally added during the reaction to increase yield on individual substrates without affecting enantioselectivity. The method avoids the traditional multi-step sequence of nitrogen protection first and then deprotection, and has the advantages of economical steps, mild conditions, feasible amplification and the like.

The invention relates to the technical field of dyes, and particularly discloses a naphthalimide benzooxygen heterocyclic yellow dye, ink and an electrowetting display device. The structural formula of the naphthalimide benzooxygen heterocyclic yellow dye is shown in the specification, wherein R1, R2 and R3 are respectively and independently selected from any one of alkyl, alkoxy, alkyl phenyl, alkoxy phenyl and thienyl. A dye main body obtained after coupling of naphthalimide and phenol mainly absorbs blue light of 400-480 nm, the substance is yellow, the main body structure has a large conjugate plane, is immiscible in polar liquid and has a good molar absorption coefficient, the solubility is improved by adding long-chain branched alkyl in the main body structure, and the dye has a good color rendering effect. The prepared dye can be dissolved in an organic solvent to prepare printing ink suitable for electrowetting display, and after the printing ink is applied to an electrowetting display device, the electrowetting display device has good aperture opening ratio, short switch response time, good electrical stability and good optical stability.

The invention discloses a polymer-based pipeline wear-resistant and low-temperature-resistant coating material and a preparation method thereof in the field of polymer materials. The material is prepared from polyamide, dynamic lipoic acid network modified polyurethane urea, a liquid crystal benzoxazole polysiloxane alternating copolymer, silicon carbide, nano niobium carbide, trimethylolpropane trimercaptopropionate, an antioxidant and a flatting agent according to a specific ratio. The preparation method comprises the following steps: carrying out melt blending granulation on the three polymer matrixes to obtain a modified resin base material, carrying out dry mixing on the modified resin base material and other components, and carrying out melt extrusion and tape casting. The two key modified compounds are respectively prepared by reacting polytetrahydrofuran with dicyclohexylmethane diisocyanate and then sequentially adding pyridine dimethyl carbinol, lipoic acid lactone and isophorone diamine; and amino polysiloxane reacts with dihydroxyphthalaldehyde, and then amino cresol is added for cyclization to obtain the amino polysiloxane. The coating material disclosed by the invention has excellent wear resistance, low temperature resistance and self-repairing function, and is suitable for extreme environments such as high-pressure hydrogen conveying pipelines.

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.