3962 results about "Pyridine" patented technology

Provided herein are compounds of Formula I" and Formula II and compositions thereof that are capable of disrupting, interrupting, and / or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Ka). The present disclosure also provides methods of treating cancers and other indications with such compounds or compositions thereof.

A pyrimido-pyridine compound, a pharmaceutical composition thereof and the use thereof. The compound and the pharmaceutical composition thereof as KRAS G12D inhibitors can be used for preparing a drug for preventing or treating KRAS G12D-related diseases, and can be particularly used for preparing a drug for preventing or treating cancers.

The invention relates to the technical field of drilling fluids, and discloses a lignite-based modified filtrate reducer for a drilling fluid and a preparation method of the lignite-based modified filtrate reducer. The lignite-based modified filtrate reducer for the drilling fluid is obtained by stirring and mixing the lignite grafted copolymer, the hydroxy propyl cellulose and the graphene oxide, drying and crushing. The steric effect generated by an oxazine ring, a pyridine ring, a triazine ring, a benzene ring and a pyrrole ring grafted into the lignite improves the temperature resistance and salt resistance of the filtrate reducer; the dispersing capacity of clay particles in a drilling fluid system is improved through sulfonic acid hydrated groups, and high-temperature coalescence of drilling fluid clay due to the high-temperature effect is avoided; a sulfonic acid anion group and a quaternary ammonium salt cation group are introduced into the filtrate reducer at the same time, so that the filtrate reducer can form a salt internal bond under the action of electrostatic force, and the salt resistance of the filtrate reducer is improved; the nano silicon dioxide increases the rigidity of the filtrate reducer, so that the filtrate reducer is not easy to curl under the conditions of high temperature and high salt.

To provide a compound which is a novel proline derivative, and to provide a pharmaceutical composition comprising the compound for the treatment of, for example, systemic sclerosis (SSc) and non-alcoholic steatohepatitis (NASH).SOLUTION: A pharmaceutical composition comprises, as a cGAS inhibitor, a compound which is a novel proline derivative encompassed by formula (I), or a prodrug, a pharmaceutically acceptable salt, or a stereoisomer of the compound.SELECTED DRAWING: None

The invention discloses a zinc-iodine battery positive electrode material based on corn straw shell derived porous carbon and a preparation method of the zinc-iodine battery positive electrode material. According to the material, corn straw shells serve as the sole carbon source, an indigenous nitrogen-doped biomass charcoal carrier with a hierarchical pore structure is prepared through pre-carbonization and KOH activation processes, and the material is characterized in that the specific surface area is larger than or equal to 1500 m < 2 > / g, and the micropore proportion is larger than 90%. The iodine is loaded on the carrier (the iodine content is greater than or equal to 45wt%) through a vacuum sublimation method to form the indigenous nitrogen-doped biomass charcoal / iodine composite material. According to the positive electrode material, through the synergistic effect of physical confinement and pyridine nitrogen chemical adsorption, the multi-iodide shuttle effect is effectively inhibited, so that the capacity retention rate of the zinc-iodine battery is greater than or equal to 93% after 40000 cycles under the current density of 2A g <-1 >, and the capacity retention rate is greater than 45% under the rate of 10A / g. The method has double benefits of agricultural waste resource utilization and high-performance energy storage device development.

The invention provides a redox imidazole covalent organic framework material as well as a preparation method and application thereof, belongs to the technical field of material preparation and photocatalytic preparation of hydrogen peroxide, and aims to solve the technical problem of low activity of a current covalent organic framework in preparation of hydrogen peroxide. The preparation method of the imidazole-connected redox type imidazole covalent organic framework material comprises the following steps: respectively reacting a reactant 2, 7-di-tert-butylpyrene-4, 5, 9, 10-tetraketone monomer with 4, 4 ', 4', 4 ', 4', 4 ', 4', 4 ', 4', 4 ', 4', 4 ', 4', 4 ', 4', 4 ', 4', 4 ' The preparation method comprises the following steps: mixing 4, 4 '-(pyridine-2, 4, 6-triyl) tribenzaldehyde and a tri (4-formylphenyl) amine monomer, adding a solvent and a catalyst, uniformly stirring, and reacting to obtain the redox type imidazole covalent organic framework material after the reaction is finished. The application comprises the following steps: adding the covalent organic framework, oxygen and the sacrificial agent into water, and reacting under the irradiation of visible light. The preparation method is green, environment-friendly, simple and easy to implement, the prepared material has good thermal stability, and efficient visible light photocatalysis preparation of hydrogen peroxide can be achieved; meanwhile, the catalyst can be recycled and has good photocatalytic stability.

The invention relates to the technical field of biosynthesis, and particularly discloses a pyridone compound as well as a biosynthesis method and application thereof. On the basis of related technologies of synthetic biology, non-ribosome peptide synthetase is modified, non-ribosome peptide synthetase mutants are heterologously expressed in various hosts, a pyridone compound is found and obtained for the first time, the chemical molecular formula of the pyridone compound is determined to be C5H4N2O3, and the pyridone compound is named as 5-aminopyridine-2, 3, 6-triketone or 5-hydroxy-3-iminopyridine-2, 3, 6-triketone or 5-hydroxy-3-iminopyridine-2, 3, 6-triketone or 5-hydroxy-3-iminopyridine-2, 3, 6-triketone. The novel pyridone compound can be used as a raw material or an intermediate to be applied to development and preparation of novel antibiotics, drugs and dyes.

The invention belongs to the field of medical chemistry, and particularly relates to a crystal form of a heterocyclic compound and a pharmaceutical composition thereof. Specifically, the invention relates to a crystal form of 4-((2R, 3S, 5R)-3-(3, 4-difluoro-2-methoxyphenyl)-5-methyl-5-(trifluoromethyl) thiacyclopentane-2-formamido) pyridine-2-formamide and a pharmaceutical composition of the crystal form of 4-((2R, 3S, 5R)-3-(3, 4-difluoro-2-methoxyphenyl)-5-methyl-5-(trifluoromethyl) thiacyclopentane-2-formamido) pyridine-2-formamide. The crystal form is good in crystallinity, excellent in chemical stability and crystal form stability, high in process safety and capable of playing a good drug effect in various animal models.

The invention discloses an aniline pyridine amino-aluminum catalyst and a preparation method and application thereof, belonging to the technical field of polyester catalysts. The invention can directly utilize an aniline pyridine amino ligand to react with an aluminum source, and directly drain the solvent after the reaction to obtain a corresponding catalyst. The invention also utilizes the synthesized catalyst to catalyze monomers such as cyclic esters and lactones to prepare biodegradable aliphatic polyesters, and the monomer conversion rate is greater than 96%. Compared with the currently commercialized stannous isooctanoate catalyst, the aniline pyridine amino-aluminum catalyst provided by the invention has higher catalytic activity and lower biological toxicity, and has certain application prospects.

The invention relates to a method for detecting pyridine in air, a test paper sheet is placed in an air environment to be detected, the color change of the test paper sheet is observed, the pyridine concentration is qualitatively judged or quantitatively judged according to the color change of the test paper sheet, and the test paper sheet is made of a filter paper sheet and a zinc-based organic-inorganic hybrid halide material. According to the method, qualitative or semi-quantitative judgment of the pyridine concentration in the air can be performed by adopting a test paper sheet and a color card or a linear correlation model standard curve graph, so that whether the pyridine content in the air exceeds the standard or not or the exceeding amplitude can be monitored, and the method has the advantages of convenience in operation and more convenience in detection.

The invention relates to a conjugated microporous polymer based on a dicarbazole structure and a preparation method and application thereof, the conjugated microporous polymer has a dicarbazole structure unit and a nitrogen-containing aromatic structure unit, the dicarbazole monomer structure is represented by the formula (I): # imgabs0 #, in the structure represented by the formula (I): R = H, R1 = C = H or R1 = H, R = C = H; the structure of the nitrogen-containing aromatic monomer is shown as a formula (II): # imgabs 1 #, wherein the aromatic structure in the structure shown as the formula (II) is any one of benzene, pyridine, pyrimidine, pyrazine and pyridazine. A plurality of conjugated microporous polymers with excellent photocatalytic performance are obtained by changing aromatic monomers with different nitrogen contents, and the conjugated microporous polymers can be applied to high-efficiency production of hydrogen peroxide under photocatalytic conditions.

The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.

The invention discloses a preparation method of a pyridine-nitrogen-rich copper monatomic catalyst and application of the pyridine-nitrogen-rich copper monatomic catalyst to ammonia production through electro-catalysis of nitrate reduction, the catalyst shows good catalytic performance of ammonia production through nitrate reduction in an alkaline medium, and theory and experiments prove that the copper monatomic catalyst with rich copper-pyridine nitrogen-carbon active sites has good catalytic performance. The adsorption energy of NO3 <-> and corresponding intermediates is improved, and the energy barrier of the rate control step is reduced, so that the process of reducing nitrate to prepare ammonia is promoted.

To provide: herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I); and processes and intermediates used for the preparation of such derivatives.SOLUTION: The present invention relates to: herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I); and processes and intermediates used for the preparation of such derivatives. The invention further provides: herbicidal compositions comprising such derivatives; and the use of such compounds and compositions in controlling undesirable plant growth, in particular the use in controlling weeds, such as broad-leaved dicotyledonous weeds, in crops of useful plants.SELECTED DRAWING: None

To provide: herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I); and processes and intermediates used for the preparation of such derivatives.SOLUTION: The present invention relates to: herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I); and processes and intermediates used for the preparation of such derivatives. The invention further provides: herbicidal compositions comprising such derivatives; and the use of such compounds and compositions in controlling undesirable plant growth, in particular the use in controlling weeds, such as broad-leaved dicotyledonous weeds, in crops of useful plants.SELECTED DRAWING: None

The invention relates to the technical field of flame-retardant coatings, and discloses a nano-material-containing super-hydrophilic flame-retardant coating and a preparation method thereof, and the nano-material-containing super-hydrophilic flame-retardant coating comprises modified epoxy resin, polyethyleneimine, a defoaming agent, a solvent and water. The modified epoxy resin is grafted and modified by aminated nano silicon dioxide, pyridine groups, amino groups and triphenyl phosphate, the aminated nano silicon dioxide and the triphenyl phosphate can effectively improve the flame retardance, the pyridine groups can play a role in corrosion prevention, the shelf life is prolonged, and the hydrophilic property of the coating is greatly improved through multi-amination. The water-based flame-retardant coating has excellent hydrophilicity, heat resistance, acid resistance, alkali resistance and flame retardance, is suitable for most production and living environments, is simple and convenient in production process, and is convenient to widely popularize.

The invention relates to multi-dynamic-bond synergistic self-repairing polyurethane and a preparation method thereof, and belongs to the technical field of polyurethane. The polyurethane is prepared from the following raw materials: poly (dihydric alcohol), diisocyanate, a pyridine chain extender, catechol and ferric ion salt. A main chain of polyurethane is formed by chain extension of polydihydric alcohol and diisocyanate through a pyridine chain extender, an end group is a catechol group exposed after end sealing of a catechol substance, on one hand, ferric ions and the catechol group form a metal coordination bond, and on the other hand, ferric ions and nitrogen atoms on pyridine form a coordination bond; the polyurethane contains multiple dynamic bonds, including coordination bonds of pyridine and iron ions, coordination bonds of catechol and iron ions, and hydrogen bonds between macromolecular chains. When the material is subjected to external pressure, the material has relatively good damping capacity due to internal friction force in a molecular chain; meanwhile, the polyurethane has good self-repairing capability at room temperature.

The invention belongs to the field of fuel cell catalyst preparation, and particularly relates to a defect-rich nitrogen-doped carbon-loaded platinum-cobalt intermetallic compound as well as a preparation method and application thereof. The invention provides a simple fused salt synthesis method capable of realizing large-scale preparation, and the fused salt synthesis method is used for preparing a novel high-activity PtCo intermetallic compound catalyst. The preparation method comprises the following steps: carrying out high-temperature calcination on two-dimensional leaf-shaped ZIF serving as a precursor under the action of KCl and NH4Cl mixed molten salt to obtain a nitrogen-doped carbon material, carrying out NH3 heat treatment on the nitrogen-doped carbon material to remove pyrrole nitrogen and pyridine nitrogen in the nitrogen-doped carbon material so as to form topological defect active sites, and preparing the nitrogen-doped carbon material. And finally, forming the defect-rich nitrogen-doped carbon-loaded PtCo intermetallic compound catalyst through a gas phase reduction method. A platinum-cobalt intermetallic compound can be anchored by topological defects, agglomeration of particles in the high-temperature synthesis process can be inhibited, the activity is improved, agglomeration and dissolution of the particles in the electrochemical reaction process are inhibited, and the durability is improved.

The present invention relates to fungicidal mixtures comprising at least one substituted pyridine (compound I) and at least one active compound II in a weight ratio of from 100: 1 to 1: 100; to a method for controlling phytopathogenic harmful fungi using a mixture of at least one compound I and at least one compound II in a weight ratio of 100: 1 to 1: 100; to the use of a mixture comprising compound I and compound II for controlling phytopathogenic harmful fungi; to agrochemical compositions comprising these mixtures; and to agrochemical compositions further comprising seeds.

The invention discloses a polypropylene synthetic paper with a bright surface and a matte surface and a preparation method thereof, which relates to the technical field of synthetic paper preparation, and is a three-layer co-extruded synthetic paper, which comprises a bright surface layer, a substrate layer and a matte surface layer from top to bottom; the substrate layer comprises the following raw materials by weight: 80-85 parts of modified polypropylene, 10-15 parts of filler; the matte surface layer comprises the following raw materials by weight: 80-85 parts of modified polypropylene, 5-10 parts of polyethylene, 1-3 parts of flame retardant, 1-3 parts of antistatic agent, 0.5-1 parts of matte flour, 0.5-1 parts of oleic acid amide lubricant and 5-10 parts of filler. The synthesized modified polypropylene contains a hindered phenol structure, a thioether group and a pyridine ring, which improves the antioxidant and antibacterial properties of the synthetic paper. The synthesized flame retardant has a macromolecular network structure, including a DOPO structure, a melamine structure and a long chain of cardanol alkane, which improves the flame retardancy, waterproofness and environmental protection of the synthetic paper.

Provided are mesoionic pyrido[1,2-a]pyrimidine compounds having a 1,2,4-oxadiazole structure, stereoisomers thereof, salts thereof, or solvates thereof, which have a simple structure and production process and are low in production cost. Specifically, for example, 1-((2-chlorothiazol-5-yl)methyl)-3-(3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)-4-oxo-4H-pyrido[1,2-a]primidinium-1-one salt (Z1) is shown.

The invention relates to the field of preparation of polyurethane damping materials, in particular to a preparation method of a repairable polyurethane damping material based on multiple hydrogen bonds and metal coordination. Compared with a traditional damping material, the damping material has a higher damping temperature range and has a good damping effect at the temperature of-20 DEG C to 60 DEG C. Multiple reversible hydrogen bonds are introduced through diamine containing amido bonds, the material is endowed with self-repairing and high mechanical strength, and damping and self-repairing performance is further enhanced through pyridine nitrogen atom metal coordination. Starting from molecular structure design, multiple hydrogen bonds and metal-ligand coordination bonds constructed on a polyurethane molecular main chain play a role in synergistic enhancement, energy can be effectively dissipated through dissociation and recombination of the multiple hydrogen bonds and fracture and association of the metal coordination bonds, and the energy consumption is reduced. The polyurethane material is endowed with excellent damping performance and self-healing capability by the dual dynamic action.

The invention provides a phosphate of a compound shown in a formula (I) and a polymorphic substance of the phosphate, and the phosphate and the polymorphic substance of the phosphate have excellent hygroscopicity, solubility and stability, have excellent druggability and are suitable for industrial production and storage. In addition, the phosphate and the polymorph thereof have excellent pharmacokinetic properties.

The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

The invention belongs to the technical field of battery materials, and discloses a nitrogen-doped asphalt-based hard carbon material as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out oxidation treatment on asphalt to obtain oxidized asphalt; carrying out nitrogen doping treatment on the oxidized asphalt to obtain an asphalt hard carbon precursor; carrying out pre-carbonization and carbonization treatment on the asphalt hard carbon precursor to prepare an asphalt-based hard carbon material; a nitrogen-containing compound is used in the nitrogen doping treatment process, and the nitrogen-containing compound comprises pyridyl and / or pyrrolyl, and hydroxyl and / or aldehyde group. According to the preparation method disclosed by the invention, the asphalt is subjected to oxidation treatment, so that the asphalt contains rich oxygen-containing groups (such as hydroxyl and aldehyde group), and pyridine nitrogen (or pyrrole nitrogen) is introduced into the oxidized asphalt through aldol reaction in the nitrogen doping treatment process, so that the capacity and rate capability of the asphalt-based hard carbon material are improved.

The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

The invention discloses a preparation method of an ultra-pure hydroxylamine aqueous solution, and relates to the field of organic chemistry and chemical industry production. The method comprises the following steps: reacting electronic-grade hydroxylamine salt with organic alkali in a proper solvent to generate hydroxylamine, then separating and removing salt and unreacted hydroxylamine in a reaction solution through a mercaptopyridine ion exchange modified membrane, and finally concentrating the solution into 50wt% ultra-high-purity hydroxylamine aqueous solution by adopting reduced pressure evaporation or multi-effect evaporation. The process has the characteristics of high efficiency, environmental protection, simplicity and easiness in operation, effectively improves the purity, yield and separation efficiency of hydroxylamine, and meets the strict requirements of electronic grade hydroxylamine on purity and metal ion content.