The invention provides a mineral collecting agent for collecting oxidized ores such as fluorite and a preparation method thereof, and belongs to the technical field of a mineral flotation collecting agent. The mineral flotation collecting agent for the oxidized ores such as fluorite is obtained by mixing Medialen, specific carbon atom fatty acid, hydroximic acid, methyl isobutyl carbinol, a surface active agent and the like, and then is used. The mineral flotation collecting agent has the characteristics of good water solubility, good dispersibility and strong preferential adsorption capacityof a target mineral, and is mainly used for flotation separation of useful minerals in the oxidized ores such as the fluorite, calcite, barite and ilmenite. A preparation method of the mineral flotation collecting agent for the oxidized ores has simple process and is easy in control of operation; and the prepared collecting agent has the advantages of strong selectivity, good dispersibility, lessdosage of chemicals, high overall efficiency of beneficiation and the like, and is of great significance for promoting the beneficiation of the minerals such as the oxidized ores.