333 results about "Palladium catalyst" patented technology

The invention belongs to the technical field of catalytic oxidation of carbon-containing industrial waste gas, and particularly relates to a Pd catalyst for catalytic combustion of carbon-containing waste gas as well as a preparation method and application of the Pd catalyst. The invention provides a Pd catalyst for catalytic oxidation of carbon-containing industrial waste gas such as CO and volatile organic pollutants VOCs. The Pd catalyst is obtained by compounding an amorphous CeO2 nano-cluster with a TiO2 substrate (marked as cCeO2 / TiO2) and indirectly regulating the form of Pd through gradient regulation of the content of the amorphous CeO2 nano-cluster by a sol-gel method on the basis of strong interaction of Pd and Ce species. The Pd catalyst prepared by the invention shows excellent low ignition temperature, high performance and certain universality in the catalytic combustion process of carbon-containing industrial waste gases such as CO and low-chain VOCs (Volatile Organic Compounds). In addition, the method for preparing the Pd catalyst is simple to operate and mild in condition, and has great industrial application potential and value.

The present invention relates to the technical field of organic synthesis, and specifically relates to a method for constructing the chirality of a pyran ring in Orforglipron by means of enzymatic catalysis, the method comprising the following steps: step S1, by using SM1 and SM2 as starting materials, carrying out a reaction under the action of a palladium catalyst and a ligand to obtain INT-1; step S2, under the catalysis of Pd / C, subjecting INT-1 to double bond hydrogenation reduction to obtain INT-2; step S3, in the presence of a solvent, a buffer salt system and enzymatic catalysis, subjecting INT-2 to hydrolysis and resolution to obtain a chirally pure intermediate INT-3; step S4, subjecting INT-3 to a Grignard reaction for cyclization, so as to synthesize a lactone intermediate INT-4; and step S5, subjecting INT-4 to reduction by means of Dibal-H, quenching same, performing extraction with dichloromethane, drying same with anhydrous sodium sulfate, and then performing reduction by means of triethylsilane to obtain a compound of general formula A. In the present invention, the chirality is constructed by means of enzymatic catalysis without the need of SFC resolution for separating isomeric impurities during the construction of the chirality, thereby reducing losses and improving yield, obtaining the target product at high yield and high chiral selectivity, and further saving expenses and reducing costs.

Provided is an alkane production method wherein a continuous reaction of an alcohol and hydrogen proceeds at a low reaction pressure, carbon reduction from the alcohol can be suppressed, and the conversion rate is excellent. This alkane production method for producing an alkane from a C8-22 alcohol comprises a step in which the alcohol and hydrogen are continuously reacted under the following conditions. (i) The reaction is carried out in the presence of a zeolite carrier supporting palladium, the reaction temperature is 180°C or higher, and the hydrogen pressure is 0 MPa to 0.7 MPa in terms of gauge pressure. (ii) The space velocity (SV) of the hydrogen relative to the volume of a catalyst in which the palladium is supported on the zeolite carrier is 1200 h–1 to 2400 h–1. (iii) The space velocity (SV) of the alcohol relative to the volume of the catalyst in which the palladium is supported on the zeolite carrier is 8 h–1. (iv) The zeolite carrier is of an H-beta type or an H-ZSM-5 type, has a molar ratio (SiO2 / AL2O3) between silica (SiO2) and alumina (AL2O3) of 23 to 27, and has a palladium support quantity of 0.1 mass% to 5 mass%.

The invention provides a synthesis method of a thioether ligand and a palladium-catalyzed 2-aryl indole compound, and designs an application of the biphenyl thioether ligand and a palladium catalyst in preparation of the 2-aryl indole compound. Indole and arylboronic acid are subjected to a reaction under the action of a palladium catalyst and a biphenyl sulfide ligand, and the structural formula of the biphenyl sulfide ligand is shown in the specification. Ar is phenyl, furyl, thienyl, naphthyl or phenyl substituted by one or more substituent groups; r1 is methyl, methoxyl, fluorine atom, chlorine atom, bromine atom or methyl ester group; r2 is the same or different and is methyl, ethyl, isopropyl, isobutyl, cyclohexyl, benzyl, n-butyl or n-hexyl; r3 is alkoxy, alkylthio, substituted amino or halogen; the palladium catalyst is a divalent palladium compound.

The application discloses a method for synthesizing organic acetylide ester through a palladium catalytic reaction and belongs to the field of organic synthesis. The organic acetylide ester is obtained through a cross-coupling reaction in the presence of a palladium catalyst, a phosphine ligand and an alkali, with terminal alkyne and di-tert-butyl dicarbonate as raw materials. The method has the advantages of high reaction yield, wide substrate range, good functional group compatibility, and the advantages of non-toxic and easy-to-obtain carbonyl source, simple operation steps and mild reaction conditions.

The application discloses a preparation method of a key intermediate of dapagliflozin, and belongs to the technical field of preparation of medical intermediates. The preparation method of the key intermediate of dapagliflozin comprises the following steps: 1, 1-ethoxy-4-methylbenzene is prepared by using p-cresol, sodium hydroxide and diethyl sulfate; 2, (4-ethoxybenzyl) phenyl sulfide is prepared by using 1-ethoxy-4-methylbenzene, thiophenol, a palladium catalyst, an alkali and an oxidant; 3, 1-benzyl-4-ethoxybenzene is prepared by using (4-ethoxybenzyl) phenyl sulfide under a hydrogen atmosphere; 4, 4-ethoxy-2'-chlorobenzhydrol is prepared by carrying out chlorination reaction on 1-benzyl-4-ethoxybenzene; and 5, 5-bromo-2-chloro-4'-ethoxybenzhydrol is prepared by carrying out bromination reaction on 4-ethoxy-2'-chlorobenzhydrol. The yield and purity of 5-bromo-2-chloro-4'-ethoxybenzhydrol prepared by the method are higher, the process is safer, and the production cost is reduced.

The application belongs to the technical field of catalysts, and provides a titanium nickel nitride-based palladium catalyst, a preparation method and application thereof. The method comprises the following steps: mixing titanium tetrachloride, nickel acetate tetrahydrate and ethanol under an ammonia atmosphere, and performing a reaction to obtain a complex powder; performing a nitriding reaction on the complex powder under an ammonia atmosphere to obtain titanium nickel nitride nanoparticles; mixing the titanium nickel nitride nanoparticles, a chloropalladic acid solution, water and a potassium borohydride solution, and performing a reaction to obtain the titanium nickel nitride-based palladium catalyst. The catalyst prepared by the application has a high specific surface area and is composed of two parts, namely a titanium nickel nitride nanoparticle carrier and a supported Pd nanocluster. Among them, nickel atoms are doped between the titanium nitride crystal lattices. The Pd nanocluster is supported on the surface of the TiNiN carrier, and by adjusting the loading amount of Pd atoms, efficient and high-selectivity catalysis of various environmental hydrogenation catalytic processes can be realized.

The application discloses a preparation method of a phenylacetic acid compound, and particularly, the application uses a substituted or unsubstituted aromatic hydrocarbon as a starting material, and under the action of a palladium catalyst (such as palladium acetate, palladium on carbon, palladium chloride, tetra-triphenyl palladium, etc.), the starting material is reacted with formaldehyde, HCl (aq) and CO to efficiently generate the phenylacetic acid compound. The method disclosed by the application only needs to start from the aromatic hydrocarbon, greatly reduces the difficulty and cost of obtaining the raw material, and avoids stimulating, sensitizing or toxic raw materials. Compared with the prior art, the method disclosed by the application has the advantages of simplicity and efficiency, cheap and easy-to-obtain raw materials, high atomic economy, high yield, green and pollution-free, easy industrialization and the like.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

A full continuous-flow preparation method of (+)-biotin, including: subjecting a cyclic anhydride and a chiral biphenyl propylene glycol to asymmetric ring-opening reaction to produce a first intermediate, which undergoes selective reduction with a borohydride and cyclization with an inorganic mineral acid to produce (3aS, 6aR)-lactone; subjecting the (3aS, 6aR)-lactone and a sulfenylating reagent to sulfenylation to produce (3aS, 6aR)-thiolactone, which undergoes Fukuyama coupling with a zinc reagent in the presence of a palladium catalyst and elimination reaction in the presence of an inorganic mineral acid to produce an alkenyl valerate compound; subjecting the alkenyl valerate compound to reduction in the presence of a Pd / C catalyst to produce a valerate ester, which undergoes hydrolysis to produce a valeric acid salt; and subjecting the valeric acid salt to debenzylation in the presence of an inorganic mineral acid to produce the target product (+)-biotin.

This invention discloses a magnetically supported thioether-chelated nitrogen heterocyclic carbene palladium complex MNPs-NHC-Pd, its preparation method, and its applications. Using an amino alcohol as a starting material, an imidazole derivative containing a hydroxyl group on the N-substituent is obtained through a condensation and ring-closing reaction. This derivative is then subjected to substitution reactions with thionyl chloride and cyclohexanethiol sequentially to obtain an imidazole derivative containing a thioether on the N-substituent. This derivative is then reacted with 1,3-dibromopropane to obtain an N-bromopropyl-N'-cyclohexane thioether-substituted imidazole bromium salt. This salt is then reacted with Pd(OAc)₂ or PdCl₂ via a direct metallization reaction to obtain the N-bromopropyl-substituted thioether-chelated nitrogen heterocyclic carbene palladium complex NHC-Pd. The NHC-Pd complex is then reacted with amino-functionalized magnetic nanoparticles (MNPs-NH₂) to prepare the magnetically supported thioether-chelated nitrogen heterocyclic carbene palladium complex MNPs-NHC-Pd. It not only possesses the activity of homogeneous nitrogen heterocyclic carbene palladium catalysts, but also has a simple synthesis method, high yield, and is easy to separate and reuse in catalytic C-C bonding reactions, showing good application prospects in the field of catalysis.

This application discloses a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring, its synthesis method, and its application, belonging to the field of organic synthesis. The synthesis method uses a haloacenaphthene derivative as a starting material. First, a tetrahalogenated key intermediate containing an eight-membered ring is constructed via a titanium tetrachloride-catalyzed cyclization tetramerization reaction. Subsequently, this intermediate undergoes a cyclization coupling reaction with an alkyne compound in the presence of a palladium catalyst, silver salt, and phosphine ligand to generate a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring. The synthesis method of this application avoids multi-step precursor synthesis, resulting in a concise process. It allows for the flexible introduction of functional groups such as trifluoromethyl and silyl groups, improving the solubility and processability of the material. The obtained product exhibits a non-planar configuration, a narrow optical band gap, and excellent electron transport properties, making it suitable for applications... n Applications include semiconductors, chiral optoelectronic materials, and nano-carbon materials.

The invention relates to the technical field of biological medicine, in particular to a novel amino acid or polypeptide side chain carbonylation modification reagent which can be used as a novel carbonylation reagent in a method for synthesizing gamma-C (sp3)-H bond carbonylation amino acid or polypeptide through palladium catalysis. Substituting ethylene with a novel carbonylation reagent 1-iodine-2-bromine under the action of a palladium catalyst, an additive and a solvent to realize carbonylation and methylation of the amino acid gamma-C (sp3)-H bond. The method disclosed by the invention has the beneficial effects that a novel carbonylation reagent easy to prepare is developed, substrate raw materials are easy to obtain, the operation is simple and convenient, the condition is mild, the substrate application range is wide, and a plurality of carbonylated amino acids and polypeptide derivatives can be efficiently and accurately synthesized at low cost; and a novel method is provided for modification of unnatural amino acids and polypeptide side chains.

This invention belongs to the field of organic synthetic chemistry technology, specifically relating to a selenium-based indoloquinazoline derivative, its preparation method, and its application, comprising: in an organic solvent, using aromatic amine compounds, malononitrile, and diselenoether as raw materials, in the presence of a palladium catalyst and an organic base, at 90°C... o The reaction was carried out under C conditions with stirring to obtain a selenyl indoline quinazoline derivative. This method features mild reaction conditions, simple operation, high yield, and good functional group compatibility, conforming to the principles of green chemistry. Furthermore, the selenyl indoline quinazoline derivative provided by this invention exhibits good inhibitory activity against Plasmodium, providing a drug lead compound for the development of novel antimalarial drugs and holding significant importance for the prevention and / or treatment of malaria.

The application discloses a preparation method of baricitinib, and belongs to the technical field of drug synthesis. The method comprises the following steps: firstly, 2-[1-(ethylsulfonyl)-3-azetidinyl]acetonitrile and 4-pyrazole boron pinacol ester are subjected to a Michael addition reaction to obtain 1-(ethylsulfonyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-3-azetidine acetonitrile as an intermediate I; secondly, a protection group is introduced on the amino group of 4-chloropyrrolopyrimidine to obtain an intermediate II; finally, the intermediate I and the intermediate II are subjected to a Suzuki coupling process by adopting a method of combining a nickel pre-catalyst with a supporting ligand to obtain the baricitinib. The preparation method creatively realizes cross coupling of the baricitinib by adopting the cheap metal nickel as a catalyst, avoids the use of a heavy metal palladium catalyst, and has the advantages of low cost, low toxicity, small pollution, green environmental protection and the like.

The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of a diaryl methane compound. A toluene derivative as shown in a formula 1, an aryl iodide as shown in a formula 2 and a styrene derivative as shown in a formula 3 are subjected to a reaction in the presence of a catalytic amount of PdCl2 (dppf) and 4, 6-di (diphenylphosphine) phenazine and an equivalent amount of LiN (SiMe3) 2 and CsF to synthesize the diaryl methane compound as shown in a formula 4. The coupling reaction of the toluene derivative, the aryl iodide and the styrene derivative is realized by adopting a catalytic amount of PdCl2 (dppf), and the palladium catalyst shows obvious catalytic performance.

The present application relates to a kind of preparation method of polythiophene conjugated polymer, in the presence of palladium catalyst, nitrogen-containing heterocyclic ligand, oxidant, deproton ligand and solvent, to be activated aromatic hydrocarbon is directly arylated polymerization reaction one step synthesis polythiophene conductive polymer by oxidation;To be activated aromatic hydrocarbon is one or more of thiophene and its derivatives;The coordination number of nitrogen-containing heterocyclic ligand and palladium is 1, and the coordination number of deproton ligand and palladium is 2;Or, the coordination number of nitrogen-containing heterocyclic ligand and palladium is 2, and the coordination number of deproton ligand and palladium is 1;The reaction transition state of metal synergistic deprotonation step participated by ligand and deproton ligand calculated by density functional theory, the W Pd‑C and W C‑H Sum calculated is not less than 0.75;The method of the present application is simple, fast, and does not need to be pre-activated for monomer, solves the problem of low yield and polymerization degree in the prior art by oxidation direct arylated polymerization to prepare polythiophene polymer.

The present application relates to the field of basic organic chemistry synthesis, and particularly to a high-yield preparation method of o-terphenyl based on hydrogen participation; comprising the steps of preparing a catalyst mixed solution, preparing a reaction mixed solution, filling micro-pressure hydrogen, heating and hydrogenation coupling reaction, rough extraction through reduced pressure distillation, and recrystallization and drying; a pre-assembly reaction precursor is formed by a bidentate phosphine bidentate phosphine ligand and a supported palladium catalyst, and a coupling reaction occurs with diphenyl under the cooperation of micro-pressure hydrogen and an acidic cocatalyst; the present application does not need to use traditional halogenated aromatic hydrocarbons and organic metal reagents, solves the problems of isomer mixing and difficult separation and halogen residue affecting the performance of downstream optoelectronic materials, realizes the preparation of o-terphenyl, and simplifies the separation and purification process.

The invention discloses a synthesis method of halauxifen-methyl. The halauxifen-methyl is obtained by carrying out Suzuki coupling reaction on 4-amino-6-bromo-3-chloro-5-fluoropyridine carboxylic acid benzyl ester and 4-chloro-2-fluoro-3-methoxyphenylboronic acid, a catalytic system adopted by the Suzuki coupling reaction is a palladium catalyst, a phosphine ligand and a phase transfer catalyst; wherein the phosphine ligand is 4-(anthracene-9-yl)-3-(tert-butyl)-2, 3-dihydrobenzo [d] [1, 3] oxaphosphorus pentadiene, and the phosphine ligand is 4-(anthracene-9-yl)-3-(tert-butyl)-2, 3-dihydrobenzo [d] [1, 3] The molar use amount of the palladium catalyst is 0.1 to 0.5 mol percent of the molar use amount of the 4-amino-6-bromo-3-chloro-5-fluoropyridine benzyl formate. According to the invention, AntPhos is used as a phosphine ligand to form a catalytic system together with the palladium catalyst and the phase transfer catalyst, so that higher reaction yield and product purity can be obtained with very low dosage of the palladium catalyst, the synthesis cost of the halauxifen-methyl can be greatly reduced, the reaction condition is mild, the energy consumption is lower, and the method is suitable for industrial production.

The invention relates to the technical field of high-frequency and high-speed substrate resin and packaging materials of microelectronic devices, and particularly discloses hydrocarbon resin of dibenzocyclobutene fluorene and derivatives thereof and a preparation method of the hydrocarbon resin, and the hydrocarbon resin is prepared by mixing 9, 9-disubstituent-9H-fluorene and / or the dibenzocyclobutene fluorene derivatives according to a specific proportion, adding a solvent, and stirring to obtain the hydrocarbon resin of the dibenzocyclobutene fluorene and the derivatives of the dibenzocyclobutene fluorene and the derivatives of the dibenzocyclobutene fluorene. And carrying out a thermocuring reaction to obtain the product. The dibenzocyclobutene fluorene derivative is prepared by carrying out Heck reaction on 9, 9-disubstituent-9H-fluorene and halogenated benzocyclobutene under the catalysis of a base catalyst and a modified palladium catalyst, the prepared hydrocarbon resin has very low dielectric constant and dielectric loss and higher softening point and peel strength, and can better meet market requirements.

The invention relates to phosphine ligands and their use in the carbonylation of acetylene / ethylene for the synthesis of acrylate / propionate. The phosphine ligands according to the invention are represented by formulas I to VIII. The invention describes the use of these phosphine ligands in combination with palladium catalysts for carbonylation reactions of acetylene or ethylene for the production of acrylate or propionate compounds. The processes are characterized by high catalytic efficiency, excellent product yields, outstanding selectivity, and ease of implementation. Particular advantages include improved reaction kinetics due to the optimized ligand structures, economical process control due to high catalyst productivity, and a broad range of applications for various acrylate and propionate derivatives. The invention is particularly suitable for industrial synthesis processes in fine chemical production.

The invention discloses selenoglycoside gligliflozin as well as a preparation method and application thereof. The structural formula of the selenoglycoside gligliflozin disclosed by the invention is shown as a formula (I). The preparation method of the seleno-glucoside gliflozin comprises the following steps: 1, directly carrying out selenium-carbon coupling reaction on peracetyl-protected 1-seleno-glucose in a solvent under the action of alkali and a palladium catalyst to prepare tetra-acetyl-protected seleno-glucoside gliflozin; and step 2, carrying out deacylation on the tetra-acetyl protected seleno-glucoside gliliflozin product to prepare the seleno-glucoside gliliflozin. A biological activity test shows that the selenoglycoside gliliflozin provided by the invention shows low toxicity to cells, high inhibitory activity to SGLT-2 (sodium glucose transporter 2) and beta-glucosidase hydrolysis resistance, so that the selenoglycoside gliliflozin has the potential to be developed into a medicine for treating diabetes mellitus 2. (I)

The invention belongs to the technical field of organic ultrathin nanomaterials, and particularly relates to a photoresponse type polymer ultrathin nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) adding dicyclohexylcarbodiimide, N-hydroxysuccinimide, N, N-diisopropylethylamine and 4-carboxyl phenylboronic acid pinacol ester into a solvent, and reacting to obtain an intermediate product; (2) carrying out heating reaction on the intermediate product, triethylene glycol and a catalyst to obtain a phenylboronic acid pinacol ester derivative; (3) adding 4, 4-dibromo azobenzene, a phenylboronic acid pinacol ester derivative, a palladium catalyst and potassium carbonate into a solvent for reaction to obtain an amphiphilic alternating copolymer; and (4) dispersing the amphiphilic alternating copolymer in a solvent for self-assembly to obtain the amphiphilic alternating copolymer. According to the invention, a photoresponse group azobenzene structure is introduced into a polymer main chain, so that the ultrathin organic material is endowed with a unique photoresponse characteristic; the method is simple and easy to implement, good in repeatability and high in stability.

The application belongs to the field of organic photovoltaics, and relates to a kind of polymer photovoltaic material and its preparation method and application. Double bromide compound A and double side tin compound B are subjected to Stille cross coupling reaction under the action of palladium catalyst, and the polymer photovoltaic material is obtained. The polymer photovoltaic material prepared by the application has an ultra-wide absorption spectrum range from 300 nm to 1200 nm. Such material exhibits an ultra-wide spectral range and a high extinction coefficient, and embodies excellent light absorption capacity. The strong light absorption capacity of the polymer photovoltaic material prepared by the application will help to improve the device efficiency of organic photovoltaics and improve the energy conversion efficiency of the device. The polymer photovoltaic material prepared by the application provides reference value for the design of functional materials in many fields of organic photoelectricity and solar energy utilization and conversion.

The utility model discloses a pressing device for carton printing, which comprises a paperboard rolling mechanism, and a harmful gas purification mechanism is arranged on the surface of the top of the paperboard rolling mechanism. The harmful gas purification mechanism comprises a gas collecting hood, a plurality of servo fans fixed on the bottom end face of the gas collecting hood and a palladium frame fixed in the middle of an inner cavity of the gas collecting hood, a honeycomb-shaped activated carbon plate is embedded and fixed in a top port of the gas collecting hood, and a plurality of electric heating rods are fixed in an upper area in the inner cavity of the gas collecting hood. By means of a closed-loop control system formed by the servo electric cylinder and the pressure sensor, dynamic adjustment of the gap between the pressing rollers is achieved, the pressing requirements of paperboards with different thicknesses can be met, the equipment universality and the pressing quality stability are improved, and the rejection rate caused by thickness fluctuation is reduced. And a three-stage purification system integrating palladium catalyst low-temperature oxidation, electric heating auxiliary pyrolysis and activated carbon deep adsorption is adopted, so that the emission concentration is ensured to be less than or equal to 2ppm, and the problem of volatile organic compound pollution in the printing industry is effectively solved.

The invention discloses a preparation method of a 3-substituted-2, 3 '-bisindole compound, and belongs to the field of organic synthesis. According to the method, 3-iodoindole with indole N-H protected by p-toluenesulfonyl and olefin are used as initial raw materials and are stirred to react in an organic solvent at 60-120 DEG C under the action of a palladium catalyst, norbornene, a phosphine ligand, an accelerant and alkali, and the 3-substituted-2, 3 '-bisindole compound can be obtained. The raw materials used in the method are cheap and easy to obtain, the reaction process is mild, the substrate universality is good, and the method has high step economy and practicability.

The application discloses a five-membered ring containing alkynyl or triazole functional group P The chiral phosphine oxide compound is obtained through Domino Heck-Sonogashira cascade reaction by taking a prochiral tertiary phosphine oxide compound containing a double ethylene group and phenylacetylene as raw materials, transition metal palladium catalyst and chiral TADDOL phosphoramidite ligand under the protection of inert gas P The chiral phosphine oxide compound has a product yield of 96% and an enantioselectivity ee value of 99%, and a diastereoselectivity dr value of greater than 20:1. The application adopts an asymmetric desymmetrization strategy, uses a Heck reaction to start and a Sonogashira reaction to end a cascade reaction, simultaneously constructs P The chiral and quaternary carbon chiral center has mild reaction conditions, simple operation and good substrate universality, provides a compound skeleton with diversity, and is successfully applied to a palladium-catalyzed asymmetric allyl substitution reaction as a chiral ligand.

The invention discloses a preparation method and application of phenyluracil, and belongs to the technical field of organic synthesis. The technical problems to be solved are to avoid the influence of amido bond dimethylation impurities on the product purity, reduce the production cost and improve the yield and the purity of the final product. The key point of the technical scheme is that a compound I-1 and a compound I-2 are subjected to a coupling reaction to obtain a compound I; the compound I-1 is shown in the specification; the compound I-2 is shown in the specification; the compound I is shown in the specification; the R1 group is selected from a group which can be subjected to oxidative addition with a palladium catalyst; and the R2 group is selected from hydrogen and methyl.

The application relates to the technical field of catalyst preparation, in particular to a kind of organic solvent-resistant recyclable supported palladium catalyst and its preparation method and application, which comprises carrier and the palladium active component supported on the surface and in the channel of the carrier, the carrier is the modified mesoporous metal oxide-activated carbon composite carrier resistant to organic solvent, the palladium active component is palladium complex, the loading amount of the palladium active component is 0.5%-5% of the mass of the carrier;The modified mesoporous metal oxide-activated carbon composite carrier is composed of mesoporous metal oxide and activated carbon after modification by silane coupling agent, and the mesoporous metal oxide is one or more of mesoporous titanium dioxide, mesoporous aluminum oxide and mesoporous zirconium oxide;Solve the problem that homogeneous palladium catalyst used in suzuki-miyaura coupling reaction in the prior art cannot be recycled, the cost is high, the product purity is affected, and the existing supported palladium catalyst has poor organic solvent resistance, low catalytic activity and poor recycling stability.

The invention provides a preparation method of a palladium catalyst for acetylene selective hydrogenation, which comprises the following steps: S1, dropwise adding an amine compound into a palladium salt solution until the pH value of a mixed solution is 6-14, and then stirring and dispersing the mixed solution to form a palladium complex solution; s2, the gamma-Al2O3 pellets are impregnated in a palladium complex solution, impregnation liquid is removed after sufficient adsorption, drying, roasting and reduction are conducted, and the palladium catalyst is obtained. According to the preparation method of the palladium catalyst for acetylene selective hydrogenation, an amine compound is used as an alkali source, a coordination agent and a stabilizer at the same time, through coordination of N atoms and Pd, large steric hindrance is formed, different Pd active centers are effectively isolated, and the prepared Pd catalyst has the advantages that the dispersion is high, ethylene and Pd are easily adsorbed in a pi bond mode, and the catalytic activity of the catalyst is improved. Therefore, the catalyst is more easily desorbed from an active center, excessive hydrogenation is avoided, and the catalyst shows high activity and ethylene selectivity in acetylene selective hydrogenation reaction.