637 results about "Palladium catalyst" patented technology

The invention belongs to the technical field of catalytic oxidation of carbon-containing industrial waste gas, and particularly relates to a Pd catalyst for catalytic combustion of carbon-containing waste gas as well as a preparation method and application of the Pd catalyst. The invention provides a Pd catalyst for catalytic oxidation of carbon-containing industrial waste gas such as CO and volatile organic pollutants VOCs. The Pd catalyst is obtained by compounding an amorphous CeO2 nano-cluster with a TiO2 substrate (marked as cCeO2 / TiO2) and indirectly regulating the form of Pd through gradient regulation of the content of the amorphous CeO2 nano-cluster by a sol-gel method on the basis of strong interaction of Pd and Ce species. The Pd catalyst prepared by the invention shows excellent low ignition temperature, high performance and certain universality in the catalytic combustion process of carbon-containing industrial waste gases such as CO and low-chain VOCs (Volatile Organic Compounds). In addition, the method for preparing the Pd catalyst is simple to operate and mild in condition, and has great industrial application potential and value.

The invention discloses a palladium catalyst as well as a preparation method and application thereof. The structural formula of the palladium catalyst is shown as a formula (I), according to the invention, an alkoxy group is introduced into the skeleton of the palladium catalyst and N-methylimidazole is coordinated with palladium, so that the catalytic yield of the palladium catalyst is effectively improved, and long-chain alkyl polyarylamine with high molecular weight and narrow distribution is obtained; the method does not need to use a traditional phosphine ligand, avoids potential hazards of phosphine compounds to operators and the environment in the use process, and is expected to be industrially applied on a large scale due to the fact that the phosphine compounds are stable to air and moisture and can be stored for a long time.

The invention belongs to the field of preparation of halogen-containing substituted benzoic acid, and particularly relates to a method for preparing o-chlorobenzoic acid through hydrogenation selective debromination. According to the invention, hydrogen is used as a reducing agent, a palladium catalyst is used as a catalyst, a methanol aqueous solution is used as a solvent, and 2-chloro-3-bromobenzoic acid, 2-chloro-5-bromobenzoic acid or a mixture thereof are used as raw materials to prepare o-chlorobenzoic acid. According to the method, debromination is controlled through selective hydrogenation instead of dechlorination, so that generation of a byproduct benzoic acid is inhibited. The scheme is reasonable in design, simple in process and mild in reaction condition, and a new thought is provided for the synthesis method of o-chlorobenzoic acid.

The invention provides a composite carrier supported palladium catalyst for preparing succinic anhydride through maleic anhydride hydrogenation and a preparation method and application thereof.The structural general formula of the composite carrier supported palladium catalyst is Pd-A-X-Y / (Z1 + Z2), Z1 in a composite carrier is made of a high-specific-surface-area porous material, Z2 is made of a high-thermal-conductivity compact material, and X is larger than or equal to 1 and smaller than or equal to 2. The active component is composed of metal Pd and transition metal such as Ni or precious metal such as Ru, and the auxiliary agent is composed of oxides of alkali metal, alkaline earth metal or rare earth elements and oxides of high-valence elements such as Mo. The catalyst is prepared by an impregnation method, and the composite carrier supported palladium catalyst has excellent low-temperature activity, tolerance and stability in a reaction for preparing succinic anhydride by maleic anhydride hydrogenation, can bear high maleic anhydride concentration and high liquid hourly space velocity at low temperature, low pressure and low hydrogen-anhydride ratio, and simultaneously obtains high maleic anhydride conversion rate and succinic anhydride selectivity.

The invention relates to the field of wave-absorbing materials, in particular to a novel aza conjugated microporous polymer wave-absorbing material and a preparation method of the novel aza conjugated microporous polymer wave-absorbing material. The conjugated microporous polymer is prepared from a dibromopyridine monomer and a borate monomer through Suzuki coupling reaction under the action of a palladium catalyst, and the polypyrrole-aza conjugated microporous polymer material with a net structure is obtained through confinement polymerization of polypyrrole in holes of the conjugated microporous polymer. According to the preparation method, a conjugated microporous polymer containing pyridine groups is synthesized through a molecular design strategy of introducing nitrogen heterocyclic rings on a conjugated microporous molecular skeleton, and polypyrrole is introduced into nanopores of the conjugated microporous polymer through a confinement polymerization method, so that the novel nitrogen heterocyclic conjugated microporous polymer wave-absorbing material is prepared. The wave-absorbing characteristic of the wave-absorbing material is obviously improved.

The present invention relates to the technical field of organic synthesis, and specifically relates to a method for constructing the chirality of a pyran ring in Orforglipron by means of enzymatic catalysis, the method comprising the following steps: step S1, by using SM1 and SM2 as starting materials, carrying out a reaction under the action of a palladium catalyst and a ligand to obtain INT-1; step S2, under the catalysis of Pd / C, subjecting INT-1 to double bond hydrogenation reduction to obtain INT-2; step S3, in the presence of a solvent, a buffer salt system and enzymatic catalysis, subjecting INT-2 to hydrolysis and resolution to obtain a chirally pure intermediate INT-3; step S4, subjecting INT-3 to a Grignard reaction for cyclization, so as to synthesize a lactone intermediate INT-4; and step S5, subjecting INT-4 to reduction by means of Dibal-H, quenching same, performing extraction with dichloromethane, drying same with anhydrous sodium sulfate, and then performing reduction by means of triethylsilane to obtain a compound of general formula A. In the present invention, the chirality is constructed by means of enzymatic catalysis without the need of SFC resolution for separating isomeric impurities during the construction of the chirality, thereby reducing losses and improving yield, obtaining the target product at high yield and high chiral selectivity, and further saving expenses and reducing costs.

The invention discloses a hydrogen-fluorine atom doped graphdiyne material and a preparation method thereof, and relates to the technical field of carbon materials. According to the method, halogenated aromatic hydrocarbon and an alkynyl compound are taken as raw materials, a palladium catalyst and a copper catalyst are taken as a catalytic system, and an acetylenic bond of the alkynyl compound and the halogenated aromatic hydrocarbon are subjected to a Sonogashira coupling reaction to obtain the hydrogen-fluorine-doped graphite alkynyl material. The graphdiyne material provided by the invention has a large pore diameter, multiple active sites and high thermal stability and chemical stability, so that the hydrofluorine-doped graphdiyne material has excellent electrochemical energy storage property, shows reversible capacity of 1155mAh g <-1 > under 0.05 Ag <-1 > when being used as a negative electrode of a lithium ion battery, and can be used as a negative electrode of the lithium ion battery. And the density is almost 3 times that of a commercial graphite negative electrode material (300-350mAh g <-1 >). The application of the graphdiyne material in the field of electrochemical energy storage is obviously promoted.

The invention provides a catalyst as well as a preparation method and application thereof and a preparation method of tetrahydrofurfuryl alcohol, the catalyst takes mesoporous silica as a carrier, the surface of the carrier is modified with polyethylene glycol and an alkyl chain to form an amphiphilic surface, and Pd nanoparticles are loaded in mesopores. The surface of the mesoporous silica supported palladium catalyst is modified with polyethylene glycol and alkyl chains through covalent bonds to form an amphiphilic interface, hydrophilic polyethylene glycol chains enrich furfuryl alcohol molecules through hydrogen bonds, and hydrophobic alkyl chains capture hydrogen microbubbles, so that the gas-liquid interfacial tension can be effectively reduced, large bubbles can be broken, and nano bubbles can stably exist; and the preparation of tetrahydrofurfuryl alcohol realizes efficient reaction under obviously reduced pressure.

The invention discloses a method for synthesizing tazobactam, which comprises the following steps: taking sulbactam as a starting material, and carrying out one-step coupling reaction on sulbactam and 1R-1, 2, 3-triazole under the action of a palladium catalyst, a proline ligand, alkali, an oxidizing agent and a corresponding solvent to obtain the tazobactam. The synthesis method is high in yield, low in cost and environment-friendly, and the synthesis process of tazobactam is greatly simplified.

This scheme belongs to the field of organic synthesis technology, discloses the synthesis method of anticancer medicine darolutamide, and the synthesis method designs a new synthesis route: using formula (S1) compound as starting material, first converted into formula (1ab) or formula (1ac) compound, and then converted into formula (TM-1) compound; the obtained formula (TM-1) compound reacts with formula (1ad) or formula (1ae) compound converted from formula (S5) compound to synthesize formula (TM-2) compound, and then converted into formula (TM-3 compound); the obtained formula (TM-3) compound reacts with formula (S6) compound to synthesize formula (TM-4) compound, and then converted into formula (TM-5) darolutamide. The synthesis process does not need to use expensive palladium catalysts or ligands, so there is no problem of heavy metal residues or heavy metal toxicity in the drug product caused by palladium catalysts in the pharmaceutical process, and there is no need to remove trace metal residues from the target product; the raw materials used are cheap and easy to obtain, the reaction system is green and environmentally friendly, simple to handle, high yield, and good purity.

The application discloses an emulsion microreactor for cascade reaction and a preparation method and application thereof. The emulsion microreactor is prepared by the following steps: acidolysis of agar, hydrophobic modification, mixing of obtained interface stable modified agar nanoparticles, enzymes and buffer to obtain an aqueous phase; mixing of a substrate, a catalyst and an organic solvent to obtain an oil phase; and mixing of the aqueous phase and the oil phase to obtain the emulsion microreactor. The emulsion microreactor is used for synthesizing 4-biphenylcarboxylic acid ethyl ester by using lipase and a metal palladium catalyst, solves the problem of poor compatibility between the catalyst metal palladium and the lipase, spatially separates the lipase and the metal palladium, improves the cascade catalytic efficiency of the metal enzyme, and finally the yield of the product 4-biphenylcarboxylic acid ethyl ester can reach 55.85%; and the metal enzyme cascade reaction is completed in one pot in the emulsion microreactor, avoids separation of an intermediate product, expands the range of catalytic reactions, and provides a reaction platform for other high-value-added pharmaceutical intermediate products.

Improved processes are provided for efficient production of elacestrant and intermediates thereof, enabling higher atom economy, improved safety, reduced consumption of palladium catalysts, and easier purification.

The invention belongs to the field of fine chemical engineering, and discloses a preparation method of halauxifen-methyl, which comprises the following steps: by taking a compound I and a compound II as raw materials and acetonitrile or an acetonitrile-water mixed solution as a reaction solvent, under the protection of nitrogen, taking a palladium catalyst as a catalyst and under the condition that a cocatalyst exists or does not exist, carrying out a reaction on the compound I and the compound II to obtain the halauxifen-methyl. And carrying out Suzuki coupling reaction on the compound I and the compound II to obtain the halauxifen-methyl. The method for preparing the halauxifen-methyl is high in novelty, the product selectivity can be improved by adding the cocatalyst, the product yield is high and at least reaches 80%, and the product purity is high. # imgabs0 #

Disclosed in the present invention is a method for preparing an ALK inhibitor compound and an intermediate thereof. Specifically, the present invention provides a method for preparing compound A9, comprising the following reaction steps: (1) carrying out a coupling reaction on "compound A2 or a salt thereof" and "compound B3 or a salt thereof" in a solvent in the presence of a metal catalyst, a ligand, and a base to obtain compound A4, wherein the metal catalyst is a palladium catalyst; and (2) carrying out a coupling reaction on compound A4 and compound A8 in a solvent in the presence of an acid to obtain compound A9. The preparation method of the present invention has the advantages of proper reaction steps, simple operation, cheap and easily available reaction raw materials, environmental friendliness, simple post-treatment, low safety risk, reduced production cycle and production cost, etc.

Provided is an alkane production method wherein a continuous reaction of an alcohol and hydrogen proceeds at a low reaction pressure, carbon reduction from the alcohol can be suppressed, and the conversion rate is excellent. This alkane production method for producing an alkane from a C8-22 alcohol comprises a step in which the alcohol and hydrogen are continuously reacted under the following conditions. (i) The reaction is carried out in the presence of a zeolite carrier supporting palladium, the reaction temperature is 180°C or higher, and the hydrogen pressure is 0 MPa to 0.7 MPa in terms of gauge pressure. (ii) The space velocity (SV) of the hydrogen relative to the volume of a catalyst in which the palladium is supported on the zeolite carrier is 1200 h–1 to 2400 h–1. (iii) The space velocity (SV) of the alcohol relative to the volume of the catalyst in which the palladium is supported on the zeolite carrier is 8 h–1. (iv) The zeolite carrier is of an H-beta type or an H-ZSM-5 type, has a molar ratio (SiO2 / AL2O3) between silica (SiO2) and alumina (AL2O3) of 23 to 27, and has a palladium support quantity of 0.1 mass% to 5 mass%.

The invention provides a synthesis method of a thioether ligand and a palladium-catalyzed 2-aryl indole compound, and designs an application of the biphenyl thioether ligand and a palladium catalyst in preparation of the 2-aryl indole compound. Indole and arylboronic acid are subjected to a reaction under the action of a palladium catalyst and a biphenyl sulfide ligand, and the structural formula of the biphenyl sulfide ligand is shown in the specification. Ar is phenyl, furyl, thienyl, naphthyl or phenyl substituted by one or more substituent groups; r1 is methyl, methoxyl, fluorine atom, chlorine atom, bromine atom or methyl ester group; r2 is the same or different and is methyl, ethyl, isopropyl, isobutyl, cyclohexyl, benzyl, n-butyl or n-hexyl; r3 is alkoxy, alkylthio, substituted amino or halogen; the palladium catalyst is a divalent palladium compound.

The application discloses a crystalline hyperbranched multi-arm copolymer, a self-supporting graphene film and a preparation and application thereof. The crystalline hyperbranched multi-arm copolymer is prepared by the following method: a hyperbranched macromolecular initiator is obtained by using an alpha-diimine palladium catalyst to catalyze ethylene and a bromine-containing functional monomer in a one-step "chain removal" copolymerization in a water-free grade solvent; and then the hyperbranched macromolecular initiator is used to initiate atom transfer radical polymerization of an acrylate functional monomer to obtain the crystalline hyperbranched multi-arm copolymer. The crystalline hyperbranched multi-arm copolymer, graphite powder and a solvent are mixed in proportion, graphene initial dispersion liquid is obtained through ultrasonic and centrifugal separation, and then the self-supporting graphene film is obtained through filtration, elution and drying in sequence. The application provides an application of the self-supporting graphene film as an electrothermal film, and the self-supporting graphene film has excellent electrothermal performance and mechanical strength.

The application discloses a method for synthesizing organic acetylide ester through a palladium catalytic reaction and belongs to the field of organic synthesis. The organic acetylide ester is obtained through a cross-coupling reaction in the presence of a palladium catalyst, a phosphine ligand and an alkali, with terminal alkyne and di-tert-butyl dicarbonate as raw materials. The method has the advantages of high reaction yield, wide substrate range, good functional group compatibility, and the advantages of non-toxic and easy-to-obtain carbonyl source, simple operation steps and mild reaction conditions.

The application discloses a preparation method of a key intermediate of dapagliflozin, and belongs to the technical field of preparation of medical intermediates. The preparation method of the key intermediate of dapagliflozin comprises the following steps: 1, 1-ethoxy-4-methylbenzene is prepared by using p-cresol, sodium hydroxide and diethyl sulfate; 2, (4-ethoxybenzyl) phenyl sulfide is prepared by using 1-ethoxy-4-methylbenzene, thiophenol, a palladium catalyst, an alkali and an oxidant; 3, 1-benzyl-4-ethoxybenzene is prepared by using (4-ethoxybenzyl) phenyl sulfide under a hydrogen atmosphere; 4, 4-ethoxy-2'-chlorobenzhydrol is prepared by carrying out chlorination reaction on 1-benzyl-4-ethoxybenzene; and 5, 5-bromo-2-chloro-4'-ethoxybenzhydrol is prepared by carrying out bromination reaction on 4-ethoxy-2'-chlorobenzhydrol. The yield and purity of 5-bromo-2-chloro-4'-ethoxybenzhydrol prepared by the method are higher, the process is safer, and the production cost is reduced.

The invention relates to the technical field of preparation of pesticide intermediates, and discloses a synthesis method of a pyrazosulfuron intermediate. The preparation method comprises the following steps: (1) in the presence of a palladium catalyst, alkali and an optional ligand, reacting a compound of formula (1) with carbon monoxide and 1, 3-dimethyl-5-hydroxypyrazole to obtain a compound of formula (2); and (2) reacting the compound shown in the formula (2) with sodium methyl mercaptide, and then carrying out oxidation reaction to obtain a compound shown in a formula (3). The intermediate (1, 3-dimethyl-1H-pyrazole-5-(4-trifluoromethyl-2-nitrobenzoyloxy)) provided by the invention is used for further preparing the intermediate 1, 3-dimethyl-1H-pyrazole-5-(4-trifluoromethyl-2-methylsulfonyl benzoyloxy) of the sulfonamide, and the method is simple in process, moderate in reaction condition, simple in post-treatment and high in industrial practicability. # imgabs0 #

The application relates to the field of organic synthetic chemistry, in particular to a diamino diphosphine tetradentate ligand, a preparation method thereof and application of the diamino diphosphine tetradentate ligand in Suzuki cross-coupling reaction. The diamino diphosphine tetradentate ligand provided by the application has a structure shown in formula I; due to special spatial structure and electronic properties, the diamino diphosphine tetradentate ligand can provide multi-point coordination to metal and form a stable complex with the metal, so that the activity and stability of a palladium catalyst can be improved, the palladium catalyst can efficiently catalyze the Suzuki cross-coupling reaction for constructing a C-C bond at an extremely low dosage, and the diamino diphosphine tetradentate ligand and the metal palladium catalyst have strong universality to Suzuki cross-coupling reaction substrates, and have wide potential application value.

The invention relates to the technical field of chemical synthesis, and discloses a preparation method and control of an abelsiril impurity A, namely 6-(4-chloro-5-fluoropyrimidine-2-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole. The preparation method comprises the following steps: S1, carrying out aromatic nucleus nucleophilic substitution reaction on a compound I and a nucleophilic reagent in an organic reagent, washing an organic phase, drying, filtering, and drying to obtain a compound II; concentrating under reduced pressure to obtain a compound II; s2, mixing the compound II, the compound III, a palladium catalyst, alkali and an organic solvent, performing heating reflux under the protection of nitrogen, performing Suzuki coupling reaction, performing vacuum concentration, and washing a filter cake with tetrahydrofuran to obtain a compound IV; s3, carrying out demethylation reaction on the compound IV to obtain a compound V; s4, the compound V reacts with a chlorination reagent, reduced pressure distillation is conducted, separation and purification are conducted, and the abelsilib impurity A is obtained. The design route provided by the invention is reasonable, the reaction site selectivity is good, and the impurity A with relatively high purity can be obtained.

The invention discloses a method and a device for preparing a D-A type thermally activated delayed fluorescent material through continuous flow. A two-section type continuous flow reaction system is adopted, wherein the first continuous flow reaction system is connected with a tubular reactor in series through a micro-channel reactor, and efficient nucleophilic substitution reaction of an electron acceptor halide and an electron donor is achieved under palladium catalysis; the second continuous flow reaction system is driven by double feeding pumps, so that a D-A type compound prepared from a precursor and nonaphenyl tertiary alcohol are subjected to Friedel-Crafts alkylation modification under the catalysis of acid, the reaction time of the two steps is greatly shortened, and the yields of the two steps are both 88% or above. Through flow rate limitation, solvent concentration, solid content and temperature-pressure cooperative control, the problems of palladium-containing catalyst slurry transmission and side reaction inhibition are solved. According to the method, continuous kilogram-level production of the TADF material is achieved, compared with a traditional process, energy consumption is reduced, intermediate separation is not needed, and a new normal form is provided for industrial preparation of the OLED material.

The application belongs to the technical field of catalysts, and provides a titanium nickel nitride-based palladium catalyst, a preparation method and application thereof. The method comprises the following steps: mixing titanium tetrachloride, nickel acetate tetrahydrate and ethanol under an ammonia atmosphere, and performing a reaction to obtain a complex powder; performing a nitriding reaction on the complex powder under an ammonia atmosphere to obtain titanium nickel nitride nanoparticles; mixing the titanium nickel nitride nanoparticles, a chloropalladic acid solution, water and a potassium borohydride solution, and performing a reaction to obtain the titanium nickel nitride-based palladium catalyst. The catalyst prepared by the application has a high specific surface area and is composed of two parts, namely a titanium nickel nitride nanoparticle carrier and a supported Pd nanocluster. Among them, nickel atoms are doped between the titanium nitride crystal lattices. The Pd nanocluster is supported on the surface of the TiNiN carrier, and by adjusting the loading amount of Pd atoms, efficient and high-selectivity catalysis of various environmental hydrogenation catalytic processes can be realized.

The application discloses a preparation method of a phenylacetic acid compound, and particularly, the application uses a substituted or unsubstituted aromatic hydrocarbon as a starting material, and under the action of a palladium catalyst (such as palladium acetate, palladium on carbon, palladium chloride, tetra-triphenyl palladium, etc.), the starting material is reacted with formaldehyde, HCl (aq) and CO to efficiently generate the phenylacetic acid compound. The method disclosed by the application only needs to start from the aromatic hydrocarbon, greatly reduces the difficulty and cost of obtaining the raw material, and avoids stimulating, sensitizing or toxic raw materials. Compared with the prior art, the method disclosed by the application has the advantages of simplicity and efficiency, cheap and easy-to-obtain raw materials, high atomic economy, high yield, green and pollution-free, easy industrialization and the like.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

The invention discloses a preparation method and application of a high-efficiency palladium catalyst for tandem ammonia borane dehydrogenation and nitro-aromatic hydrogenation reaction. The catalyst for the tandem ammonia borane dehydrogenation and nitro-aromatic hydrogenation reaction is a porous nitrogen-doped carbon material with palladium nanoparticles uniformly enriched in pore channels, the specific surface area of the catalyst is 120.18 m < 2 > / g, and the average pore size is 4-6 nm. The catalyst disclosed by the invention is applied to tandem ammonia borane dehydrogenation and nitro-aromatic hydrogenation reaction, water is used as a solvent in the reaction process, and the catalyst has the advantages of green synthesis, high activity, high selectivity and high stability.

A full continuous-flow preparation method of (+)-biotin, including: subjecting a cyclic anhydride and a chiral biphenyl propylene glycol to asymmetric ring-opening reaction to produce a first intermediate, which undergoes selective reduction with a borohydride and cyclization with an inorganic mineral acid to produce (3aS, 6aR)-lactone; subjecting the (3aS, 6aR)-lactone and a sulfenylating reagent to sulfenylation to produce (3aS, 6aR)-thiolactone, which undergoes Fukuyama coupling with a zinc reagent in the presence of a palladium catalyst and elimination reaction in the presence of an inorganic mineral acid to produce an alkenyl valerate compound; subjecting the alkenyl valerate compound to reduction in the presence of a Pd / C catalyst to produce a valerate ester, which undergoes hydrolysis to produce a valeric acid salt; and subjecting the valeric acid salt to debenzylation in the presence of an inorganic mineral acid to produce the target product (+)-biotin.

The present invention discloses a method for synthesizing vinylene carbonate and its derivatives, comprising: reacting a chain carbonate represented by formula (I), an olefin represented by formula (II) and an oxygen donor in the presence of a palladium catalyst and optionally a metal carbonate to produce a vinylene carbonate and its derivatives represented by formula (III); in formula (I), R1 and R2 are independently selected from alkyl or aryl groups; in formula (II), R3 and R4 are independently selected from hydrogen or alkyl groups; in formula (III), R3 and R4 are the same as described above; this method not only has an ideal yield, especially with few by-products and easy purification, but also avoids the drawbacks of the existing solutions that usually use ethylene chlorocarbonate as an intermediate, etc., and is suitable for large-scale industrial production.

The invention provides a benzo-silicon hybrid eight-membered ring compound with a stereo axis, which is constructed based on palladium-catalyzed alkyne insertion / C-H activation / ring expansion. According to the method, aryl halide, alkyne and silacyclobutane which are simple and easy to obtain are used as initial raw materials and are stirred to react in an organic solvent at the temperature of 40-120 DEG C under the action of a palladium catalyst, a phosphine ligand and alkali, and the benzo-silicon hybrid eight-membered ring compound can be obtained. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good regioselectivity, wide substrate application range, easy amplification and the like.