2191results about How to "Reduce inhibition" patented technology

Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. Thelower eukaryotes, which ordinarily produce high-mannose containing N-glycans, including unicellular and multicellular fungi are modified to produce N-glycans such as Man5GlcNAc2 or other structures along human glycosylation pathways. This is achieved using a combination of engineering and / or selection of strains which: do not express certain enzymes which create the undesirable complex structures characteristic of the fungal glycoproteins, which express exogenous enzymes selected either to have optimal activity under the conditions present in the fungi where activity is desired, or which are targeted to an organelle where optimal activity is achieved, and combinations thereof wherein the genetically engineered eukaryote expresses multiple exogenous enzymes required to produce “human-like” glycoproteins.

A display device with a touch panel includes a display panel, and an electrostatic-capacitance-coupling touch panel which is arranged on a viewer-side surface of the display panel. The touch panel includes a substrate; a first shield conductor which is formed on the viewer-side surface of the substrate; an insulation film which is formed on the first shield conductor; a plurality of first electrodes which are formed on the insulation film, extend in the first direction and are arranged parallel to each other in the second direction which intersects with the first direction; and a plurality of second electrodes which are formed on the insulation film, extend in the second direction and are arranged parallel to each other in the first direction which intersects with the second direction. A predetermined signal is inputted to the first shield conductor.

An emission control catalyst that exhibits improved CO and HC reduction performance includes a supported platinum-based catalyst, and a supported palladium-gold catalyst. The two catalysts are coated onto different layers, zones, or monoliths of the substrate for the emission control catalyst such that the platinum-based catalyst encounters the exhaust stream before the palladium-gold catalyst. Zeolite may be added to the emission control catalyst as a hydrocarbon absorbing component to boost the oxidation activity of the palladium-gold catalyst.

The teachings as provided herein relate to a watermark embedded in an image that has the property of being relatively indecipherable under normal light, and yet decipherable under UV light. This fluorescent mark comprises a substrate containing optical brightening agents, and a first colorant mixture pattern printed as an image upon the substrate. The colorant mixture pattern layer has as characteristics a property of strongly suppressing substrate fluorescence, as well as a property of low contrast under normal illumination against the substrate or a second colorant mixture pattern printed in close spatial proximity to the first colorant mixture pattern. The second colorant mixture pattern having a property of providing a differing level of substrate fluorescence suppression from the first such that the resultant image rendered substrate suitably exposed to an ultra-violet light source, will yield a discernable image evident as a fluorescent mark.

Polyenylphosphatidylcholine in combination with an alkanolamine are topically applied to treat skin wounds, promote healing, and minmize scar formation. Typical compositions contain from about 0.25% to about 12% of a polyenylphosphatidylcholine preparation obtained from natural sources such as soybean oil which contains at least about 25% by weight, preferably about 40% or more, dilinoeoylphosphatidylcholine, and from about 0.1% to about 10% by weight of an alkanolamine such as ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline, serine, or mixtures thereof. Dimethylaminoethanol is a particularly preferred alkanolamine. Tyrosine is an adjunct ingredient in many embodiments.

A process for separating the components of lignocellulosic biomass for the purpose of producing a pure reactive cellulose is disclosed. The process has two stages. In the first stage, the lignocellulosic biomass is pretreated with steam, with or without an acid catalyst, and then pressed, with or without the presence of an eluent, to remove hemicellulose and other impurities. In the second stage, the pretreated biomass is extracted with a solvent such as ethanol with or without acid catalysts in order to remove lignin and release a purified cellulose stream. The extracted cellulose is then rapidly decompressed to rupture the fibrous structure. The process provides a purified cellulose stream that is relatively easy to hydrolyze with enzymes and ferment to biofuels and other chemicals such as ethanol.

An emission control catalyst that exhibits improved CO and HC reduction performance includes a supported platinum-based catalyst, and a supported palladium-gold catalyst. The two catalysts are coated onto different layers, zones, or monoliths of the substrate for the emission control catalyst such that the platinum-based catalyst encounters the exhaust stream before the palladium-gold catalyst. Zeolite may be added to the emission control catalyst as a hydrocarbon absorbing component to boost the oxidation activity of the palladium-gold catalyst.

The invention provides a method for substantially reducing the size of a thrombus in a blood vessel in which blood is flowing. The method includes delivering a heat transfer element to a blood vessel in fluid communication with a thrombosed blood vessel. The temperature of the heat transfer element is adjusted such that the same is sufficient to remove heat from the flowing blood. Heat is transferred from a volume including the thrombus to the heat transfer element. In a separate embodiment, heat may be delivered to the volume including the thrombus from the heat transfer element. The resultant temperature of the volume may be sufficient to substantially reduce the size of a thrombus. For example, the resultant temperature of the volume may be sufficiently high to substantially enhance plasminogen activation near the thrombus. In a separate embodiment, a therapeutic drug may be delivered to the blood vessel to further reduce the size of a thrombus, the drug having an optimal temperature at the hypothermic or hyperthermic temperature of the blood.

A prepreg for a printed wiring board, comprising a cyanate ester resin having a specific structure, a non-halogen epoxy resin, a silicone rubber powder as a rubber elasticity powder, an inorganic filler and a base material, which prepreg retains heat resistance owing to a stiff resin skeleton structure, has high-degree flame retardancy without the use of a halogen compound or a phosphorus compound as a flame retardant, and has a small thermal expansion coefficient in plane direction without using a large amount of inorganic filler, and a laminate comprising the above prepreg.

A method for recovering inorganic salt during processing of a lignocellulosic feedstock is provided. The method comprises pretreating the lignocellulosic feedstock by adding an acid to the feedstock to produce a pretreated lignocellulosic feedstock. A soluble base is then added to the pretreated lignocellulosic feedstock to adjust the pH and produce a neutralized feedstock. The neutralized feedstock is then enzymatically hydrolyzed to produce an enzyme hydrolyzed feedstock and a sugar stream. Inorganic salt is recovered from either a stream obtained from the lignocellulosic feedstock prior to the step of pretreating, a stream obtained from the pretreated lignocellulosic feedstock, a stream obtained from the neutralized feedstock, a stream obtained from the sugar stream, or a combination of these streams. The inorganic salt may be concentrated, clarified, recovered and purified by crystallization, electrodialysis drying, or agglomeration and granulation, and then used as desired, for example as a fertilizer.

A packet detection apparatus detects a packet from a received signal by using a preamble containing an established, repeating training sequence. A first autocorrelation calculator computes a first autocorrelation of the received signal over a first interval. A first determining unit determines packet discovery by comparing the first autocorrelation to a first autocorrelation threshold value. A second autocorrelation calculator computes a second autocorrelation of the received signal over a second interval equivalent to the interval length for packet discovery announcement. A second determining unit determines packet discovery announcement by comparing the second autocorrelation to a second autocorrelation threshold value lower than the first autocorrelation threshold value.

This invention relates to antibodies and antigen binding fragments and conjugates containing same, and / or alternative scaffolds, specific for LSR molecules, which are suitable drugs for immunotherapy and treatment of specific cancer.

A process for producing ethanol from a fibrous lignocellulosic raw material. After pre-treatment of the raw material, the fibrous fraction is first hydrolysed at high consistency and then the modified material is subjected simultaneously to continued hydrolysis with a cellulase and to ethanol fermentation in a fermentation mixture. Fermentation is continued to convert an essential portion of the available cellulose into ethanol, then a liquid fraction containing solubilized hemicelluloses is added to the fermentation mixture and fermentation continued. By means of the invention, high fermentation rates, high ethanol concentrations and low ethanol production costs can be attained.

The invention discloses a liquid crystal display device. The liquid crystal display device comprises an array substrate, a color film substrate opposite to the array substrate and a liquid crystal layer sandwiched between the array substrate and the color film substrate, wherein the array substrate comprises a first transparent base as well as first electrodes and second electrodes formed on the first transparent base, the first electrodes and the second electrodes are arranged on different layers, and an insulation layer is arranged therebetween; the color film substrate comprises a second transparent base as well as black matrixs formed on the second transparent base, third electrodes, a photoresist layer and optical clearance objects; the third electrodes cover the black matrix and the surface on which the black matrix is not arranged, of the transparent base, the photoresist layer covers the third electrodes, the optical clearance objects cover the photoresist layer, and the optical clearance objects comprise a plane layer covered with the photoresist layer and optical clearances integrally extending from the plane layer and used for providing interval support for the liquid crystal layer; liquid crystal molecules in the liquid crystal layer are negative.

An optical filter and a lighting device using the same wherein the suppression of the melatonin secretion by the reception of light in the nighttime is prevented and the color of light is maintained. The optical filter has a mean transmissivity of a light beam in a wavelength range of about 480˜550 nm is about 30% or less. The optical filter is formed by at least molding a transparent resin and a resin composition material containing an orange color series florescent dye material, and, for 100 weight part of the transparent resin, the resin composition material containing about 0.005˜0.2 weight part of the orange color series florescent dye material is molded. This can prevent the suppression of the melatonin secretion in the nighttime. The color of light is maintained desirable. The optical filter may be applied to a lighting apparatus.

A driver circuit includes a circuit 200, a transistor 101—1, and a transistor 101—2. A signal is selectively input from the circuit 200 to a gate of the transistor 101—1 and the transistor 101—2, so that the transistor 1011 and the transistor 101—2 are controlled to be on or off. The transistor 101—1 and the transistor 101—2 are turned on or off; thus, the wiring 112 and the wiring 111 become conducting or non-conducting.

A method for recovering inorganic salt during processing of a lignocellulosic feedstock is provided. The method comprises pretreating the lignocellulosic feedstock by adding an acid or a base to the feedstock to produce a pretreated lignocellulosic feedstock. A soluble base or acid is then added to the pretreated lignocellulosic feedstock to adjust the pH and produce a neutralized feedstock. The neutralized feedstock is then hydrolyzed to produce an hydrolyzed feedstock and a sugar stream. Inorganic salt is recovered from a wash stream obtained from the pretreated lignocellulosic feedstock, a stream obtained from the neutralized feedstock, a stream obtained from the sugar stream, or a combination of these streams. The inorganic salt may be concentrated, clarified, recovered and purified by crystallization, electrodialysis, drying, or agglomeration and granulation, and then used as desired, for example, as a fertilizer.

The invention relates to a system and a method for eliminating common station site interference. The system comprises a first coupler, a transmission unit, an adjustment unit, an offset unit and a detection control unit, wherein the first coupler is used for extracting a signal transmitted by an interference base station as an interference offset signal, and coupling the interference offset signal to the transmission unit; the transmission unit is used for transmitting the interference offset signal to the adjustment unit; the adjustment unit is used for carrying out time delay, amplitude andphase adjustment of the interference offset signal to ensure that the interference offset signal and an interference signal received by a receiver from the interference base station through a wireless path have identical amplitudes and 180-degree phase difference; the offset unit is used for adding the interference offset signal adjusted by the adjustment unit to the interference signal received by the receiver from the interference base station, thereby offsetting the interference signal from the interference base station; and the detection control unit is used for controlling the adjustmentunit to carry out time delay, amplitude and phase adjustment of the interference offset signal according to the interference signal received by the receiver from the interference base station.

The present invention relates to improved methods of treating fibrotic or fibroproliferative disorders. Conjoint therapies are provided comprising the combination of one or more fibrocyte suppressors and one or more profibrotic factor antagonists or anti-fibrotic agents.

Various bispecific antibodies that specifically bind to both blood coagulation factor IX / activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that specifically bind amyloid proteins, peptides or fragments and change the conformation.

Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower eukaryotes, which ordinarily produce high-mannose containing N-glycans, including unicellular and multicellular fungi are modified to produce N-glycans such as Man5GlcNAc2 or other structures along human glycosylation pathways. This is achieved using a combination of engineering and / or selection of strains which: do not express certain enzymes which create the undesirable complex structures characteristic of the fungal glycoproteins, which express exogenous enzymes selected either to have optimal activity under the conditions present in the fungi where activity is desired, or which are targeted to an organelle where optimal activity is achieved, and combinations thereof wherein the genetically engineered eukaryote expresses multiple exogenous enzymes required to produce “human-like” glycoproteins.

Composition and methods of using melanin, or melanin-promoting compounds, for inhibiting angiogenesis to treat angiogenesis-dependent diseases, such as macular degeneration and cancer.

The present invention can sufficiently suppress curling phenomenon of a recorded product and facilitate handling of a printed product produced by using plain paper, in particular. The present invention provides a printing medium coating solution including water and a water-retentive, water-soluble organic compound, wherein the water-soluble organic compound includes only a water-soluble organic compound showing a difference of 36% or less between the water retention ability at a temperature of 23° C. and a humidity of 45% and the water retention ability at a temperature of 30° C. and a humidity of 80%; and the content of the water-soluble organic compound is 15 mass % or more with respect to the total amount of the printing medium coating solution. The present invention provides an ink-jet ink including a coloring material, water, and a water-retentive, water-soluble organic compound, wherein the water-soluble organic compound includes only a water-soluble organic compound showing a difference of 36% or less between the water retention ability at a temperature of 23° C. and a humidity of 45% and the water retention ability at a temperature of 30° C. and a humidity of 80%; and the content of the water-soluble organic compound is 15 mass % or more with respect to the total amount of the ink-jet ink.

The invention provides a remote diagnosis system capable of accurately grasping a vehicle failure occurring time with little information processing burden in vehicle. A data communication device of the invention is communicated with a remote diagnosis server outside the vehicle. The communication device comprises: a receiving part for receiving data from a vehicle network; and a vehicle state data storage for storing the vehicle state data relative with the vehicle state received from the vehicle state by the receiving part. The data communication device also comprises: a failure information storage for responding a failure code expressing the vehicle failure received from the vehicle network by the receiving part, storing the vehicle state data with an attached timestamp and the failure code as failure information; and a data communication part for responding a request signal received from the server and transmitting the failure information stored in the failure information storage to the server.

The invention discloses a device and a method for denitrification of single stage autotroph in low-cellulose nitrate (CN) high-ammonia nitrogen waste water. The device comprises a raw water tank, a water inlet pump, a reactor, a secondary sedimentation tank and a sludge reflux pump, wherein overcurrent holes are arranged in the water flow direction of the reactor in an up-and-down alternative form and connected with various grid chambers, an anoxic zone grid chamber is arranged at the front end of the reactor, and an aerobic zone grid chamber is arranged at the back end of the reactor; the anoxic zone grid chamber is provided with a stirrer and an agitator blade; the aerobic zone grid chamber is provided with the stirrer, the agitator blade, an aeration riser pipe and an intermediate perforated clapboard; and the aeration riser pipe is internally provided with an aeration head, and sponge filling material is filled below the intermediate perforated clapboard, wherein filling ratio is 30-50%. In the method, shortcut nitrification is achieved above the aerobic zone through low dissolved oxygen (DO is 0.5 <-1>mg / L) and free ammonia (FA) inhibition so that ammonia nitrogen is converted to nitrite nitrogen; and anoxicammoxidation biomembrane acts on the lower part of the aerobic zone, the nitrite nitrogen and ammonia nitrogen are converted to nitrogen, thereby achieving denitrification of autotroph. The method has the advantages of low oxygen consumption, less sludge output and no extra carbon source.

A method for treating municipal solid waste and other waste is provided which comprises: introducing said waste into a rotary autoclave which is downwardly inclined towards its discharge end and has a door at the discharge end; and injecting steam through said door into said autoclave to treat the load. A method is also provided for treating waste, comprising steam autoclaving the waste, anaerobically digesting an organic-rich fraction of the autoclaved waste, recovering methane-containing gas from anaerobic digestion, internally combusting the methane-containing gas to generate power and exhaust gas, and generating steam for autoclaving using the waste heat. A plant for treating the waste may comprise at least one autoclave for steam treating the waste, at least one anaerobic digestion tank for digesting an organic-rich fraction of the autoclaved waste, a recovery system for recovering methane-containing gas from the or each digestion tank, at least one internal combustion engine for combusting the methane-containing gas and generating power, and a steam generator fed with combustion gas from the internal combustion engine for generating and accumulating steam for supply to said at least one autoclave. Also provided is a method of treating waste material in a rotary autoclave, which comprises: loading the waste material into a top opening of the autoclave whilst rotating the autoclave in a first direction in which screw flights within the autoclave convey the waste forwardly along a downwardly inclined body of the autoclave towards a base of the autoclave; rotating the autoclave in a second direction opposite to the first direction so as to establish a circulation of the loaded material between the upper and lower ends of the autoclave to facilitate vacuum and / or steam treatment thereof; and monitoring the load imparted by the autoclave adjacent upper and lower ends thereof during the reverse rotation, increase of the load adjacent the upper end of the autoclave providing an indication of effective load circulation. A door structure for a commercial-scale autoclave based on a castellated door and a locking ring with lock blocks of inwardly facing U-structure is also provided.

Production of fermentation products, such as ethanol and lactic acid in biofilm reactors by microorganisms immobilised on sterilised granular sludge.