53 results about "Fibril" patented technology

An oral care composition with retinoid compound, amino acid, and / or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and / or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and / or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.

Embodiments are directed to a UPEC conjugate peptide including a self-assembling peptide and at least one UPEC epitope. The UPEC conjugate peptide may self-assemble into a nanofiber or fibril. Compositions including the UPEC conjugate peptide may be used to treat a bacterial infection such as a urinary tract infection (UTI). The compositions and methods may be specific for pathogenic bacteria. The compositions and methods may treat the infection without altering the gut microbiome.

The invention discloses a preparation method and application of a degradable cellulose nano-fibril-metal composite material. The preparation method comprises the following steps: S1, preparing a cellulose nano-fibril carrier; S2, chelating metal ions; and S3, carrying out film treatment. The application refers to the application in crop rhizosphere or phyllosphere micronutrient supplement. The invention develops a compound fertilizer system which takes natural cellulose nanofibril as a carrier and chelates trace metal ions through functional groups such as surface carboxyl / hydroxyl and the like, and the compound fertilizer has high specific surface area and stronger metal ion loading capacity; stable loading and slow release are realized through interface adsorption and complexation; the material is completely degradable and is ecological and environment-friendly; the fertilizer can be applied to soil or leaf surfaces and is suitable for various crop types; the process is simplified, and the method has the advantage of convenient industrial popularization.

A manufacturing method of a fiber includes: mixing and stirring a plurality of raw materials, to form a mixed liquid, where the plurality of raw materials includes dry copper nanopowder with a particle size not more than 48 nm, a fiber slurry, and an additive; drying the mixed liquid, to remove moisture of the mixed liquid and form a processed raw material; heating the processed raw material, to make the processed raw material be in a semi-molten state; electrifying the processed raw material in the semi-molten state, and then extruding at least one fibril from the processed raw material in the semi-molten state; stretching the at least one fibril; and performing cooling and shaping on at least one stretched fibril, to form a final fiber product.

The invention relates to the use of scyllo-inositol alone or in combination with other active ingredients including the compound N-acetylcysteine or a derivative thereof to support cognitive health in a subject that takes the product or combination product. The compositions, which are inclusive of oral dosage forms such as tablets or capsules, are provided to the subject which is inclusive of humans or other mammals such as dogs or cats or other animals in need of cognitive improvement. The combination product(s) break up amyloid beta aggregates and promote the clearance of amyloid beta fibrils from the glymphatic system as well as the treatment of disease and conditions that are acerbated by free radicals.

The invention discloses a bionic heterogeneous tissue engineering meniscus stent and a preparation method thereof, and discloses application of the bionic heterogeneous tissue engineering meniscus stent in the field of meniscus repair. Based on a multi-nozzle 3D printing technology, a biodegradable high polymer material and bio-ink loaded with growth factors / stem cells are innovatively adopted, and the highly bionic heterogeneous tissue engineering meniscus is constructed. Specifically, degradable macromolecular polycaprolactone (PCL) is used as a raw material, and annular and radial fibers are printed to form a stent frame by accurately regulating and controlling a printing path and simulating a natural meniscus collagenous fiber distribution rule; on the basis, biological ink loaded with differentiated growth factors and stem cells is printed in a staggered manner according to different physiological characteristics of a red region and a white region of the meniscus, so that partitioned precise inoculation of seed cells and controllable partitioned release of the growth factors are realized, and a cell microenvironment with spatial specificity is provided for meniscus regeneration; the tissue repair efficiency and the bionic integrating degree are obviously improved.

The present invention provides a guided bone regeneration (GBR) material with antibacterial properties. The GBR material is a multi-component material, including an eggshell membrane (ESM) which is functionalized by mineralization in the presence of low-molecular-weight polyacrylic acid (LPAA). Thus, the ESM therefore includes at least one mineral deposited therein, preferably, intrafibrillar deposition, for example apatite and effective amounts of LPAA. The mineralized GBR material is preferably porous, and has good mechanical properties. A method of making mineralized GBR material which preferably contains intrafibrillar mineralization is also provided.

The present application belongs to the field of biomedical materials, and particularly relates to collagen fibers with mesoscopic aggregates as structural units for biomedical materials and a preparation method thereof. The preparation method comprises the following steps in sequence: a step of splitting natural collagen aggregates from animal tissues, a step of regulating the mesoscopic size of the natural collagen aggregates, a step of assembling a fiber preparation device, a step of preparing collagen fibers with the natural collagen aggregates as structural units, and a step of twisting the collagen fibers. Compared with conventional solution method for preparing collagen fibers, the present application uses mesoscopic aggregates as structural units for preparing collagen fibers, and the obtained fibers have excellent mechanical properties, good biocompatibility and wound healing promoting performance.

The present invention relates to specific antibodies and use thereof, such as for identifying and / or quantifying liraglutide fibrils and / or semaglutide fibrils.

The present invention includes a method of treating fibrosis in a human patient in need thereof comprising administering to the human patient in need of treatment a therapeutically effective amount of Prolactin-Inducible Protein (PIP) which is capable of inhibiting or reversing the formation of pathogenic fibrils, e g., fibrosis that affects at least one organ selected from the group consisting of skin, intestine, heart, liver, lung, and kidney.

A system and method for protein detection are provided, configured to non-invasively identify proteins exhibiting specific structural conformations within a biological target. The system comprises a light source operable to irradiate the target at a predetermined pulse cycle, a sound detection device configured to capture acoustic signals generated via the photoacoustic effect, and an information processing unit that analyzes the detected acoustic signals to determine the presence or accumulation of a target protein. This technique facilitates early-stage detection of disease-associated proteins, such as amyloid-β and misfolded α-synuclein fibrils, without requiring complex imaging modalities or invasive biopsy procedures.

The present technique pertains to a method of preparation of a succinylated collagen-fibrinogen hydrogel and a succinylated collagen-fibrinogen hydrogel prepared thereby. The method of preparation of a succinylated collagen-fibrinogen hydrogel according to the present technique can produce a collagen-based bio-substance in a simple process, wherein collagen can be prevented from being entangled and an improvement can be brought about in hydrophilicity, cell growth rate, cell compatibility, and cell diffusion capability, whereby the collagen-based bio-substance exhibits excellent biocompatibility in vivo.

This invention provides a biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold, its preparation method, and its application, relating to the technical field of tissue engineering scaffolds. The biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold comprises, from the inside out, a cementum repair layer, a periodontal ligament repair layer, and an alveolar bone repair layer; the cementum repair layer and the alveolar bone repair layer include a mineralized hydrogel layer; wherein the raw materials for preparing the mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and hydroxyapatite; the alveolar bone repair layer includes a non-mineralized hydrogel layer; wherein the raw materials for preparing the non-mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and fibrin I. This invention precisely matches the mechanical and biological requirements of each layer of the periodontal complex through a three-layer structure, a reversibly hydrazone-regulated viscoelastic gradient, and a differentiated biochemical microenvironment of nHAp / FBN1.

The invention relates to the technical field of artificial prostheses, and discloses an artificial cervical intervertebral disc based on a biological bionic structure, which comprises an upper end plate, a lower end plate and an elastomer core arranged between the upper end plate and the lower end plate, the elastomer core comprises a front annulus fibrosus, a nucleus pulposus and a rear annulus fibrosus; the front fiber ring is composed of an outer side fiber layer, a middle transition layer, an inner side fiber layer and front collagenous fibers located among the fiber layers. The artificial cervical intervertebral disc can be more naturally matched with the physiological movement mode of vertebrae after being implanted by adopting differentiated arrangement of front and rear fibrous rings, gradient dip angle design of collagenous fibers, elastic deformation characteristics of nucleus pulposus and material combination with different elastic moduli; the irregular-shaped end plate is more attached to the cervical vertebra hook process joint and adapts to multi-direction complex movement.

A tapered implantable device includes an ePTFE tubular member having a tapered length portion. The tapered length portion provides rapid recovery properties. The tapered length portion can feature a microstructure that includes a multiplicity of bent fibrils.

The present invention relates to a method for producing collagen-containing anisotropic fibers, the method comprising: a step for bringing an anionic polymer into contact with an aqueous collagen solution in which collagen has been dissolved to form an interface, so that the collagen is formed into fibrils; and a step for pulling up the fibrillated collagen from the aqueous collagen solution with which the anionic polymer has been brought into contact so as to form anisotropic fibers. The present invention also relates to a method for producing a collagen-containing structure having in the interior thereof a hollow structure filled with an aqueous medium, the method comprising: a step for forming, in an aqueous solution containing an anionic polymer, droplets of an aqueous solution in which at least collagen is dissolved; and after the step for forming the droplets, a step for allowing the droplets to stand for a certain period of time to aggregate collagen molecules at the interface between the droplets and the aqueous solution containing the anionic polymer.

Disclosed herein are systems and methods for testing effects of simulated microgravity on muscle structures. The system includes a clinostat and an adapter that is receivable into the clinostat. The adapter includes a housing that defines at least one receptacle. The system further includes an assembly having a substrate and a plurality of fibrils deposited on the substrate. The plurality of fibrils comprise collagen and extend along an axis. The assembly is receivable into a first receptacle of the at least one receptacle. The plurality of fibrils can have myoblasts thereon. Operation of the clinostat simulates microgravity. Test substances can screened using the muscle structures to determine effects on myogenesis.

The present invention relates to a fibrillar hydrogel comprising an aqueous solution and substantially aligned fibrils composed of collagen and at least one proteoglycan, having viscoelastic characteristics enabling its use in a wide range of industries, including but not limited to the food industry, biomaterial industry, pharmaceutic industry, and cosmetics, as well as for research purposes.

The application relates to the technical field of artificial prostheses, and discloses an artificial cervical intervertebral disc based on a biological bionic structure, which comprises an upper endplate, a lower endplate and an elastic body core arranged between the upper endplate and the lower endplate; the elastic body core comprises an anterior annulus fibrosus, a nucleus pulposus and a posterior annulus fibrosus; the anterior annulus fibrosus is composed of an outer fiber layer, an intermediate transition layer and an inner fiber layer and anterior collagen fibers arranged between the fiber layers; the application reproduces the structural composition and configuration of a biological cervical intervertebral disc, adopts differentiated arrangement of the anterior and posterior annulus fibrosus, gradient inclination angle design of the collagen fibers, elastic deformation characteristics of the nucleus pulposus and material combination with different elastic moduli, so that the artificial cervical intervertebral disc can be more naturally matched with the physiological movement mode of the vertebrae after being implanted; and the irregular endplate is more suitable for the cervical uncinate joint and is adapted to complex movement in multiple directions.

The present disclosure is based, in part, on the discovery of antibodies, such as BAN0805, that selectively target human alpha-synuclein aggregates, such as oligomers / fibrils. BAN0805 has a lower propensity to bind to undesired monomeric alpha-synuclein targets compared to mouse monoclonal antibody mAb47.

To provide an analyzing method for collagen fibers that includes a process of bringing a sample and a fluorescent probe into contact with each other and a process of detecting the fluorescent probe.SOLUTION: There is provided an analyzing method for collagen fibers, which includes a process of bringing a sample and a fluorescent probe into contact with each other and a process of detecting the fluorescent probe. wherein the fluorescent probe is selected from the group of diamino fluorescein-FM (DAF-FM), diamino rhodamine-4M(DAR-4M), diamino fluorescein FM diacetate (DAF-FM DA), diamino rhodamine-4M acetoxymethyl ester (DAR-4M AM), derivatives thereof, and combinations thereof.SELECTED DRAWING: Figure 1

Provided is a method for producing a medical device 5, wherein the medical device 5 is subjected to cleaning, disinfection, or sterilization using a chemical to enable repeated use thereof. This method for producing a medical device includes a step for changing the orientation of fibrils 120 by subjecting the outer surface, which is formed from a resin material, of the medical device 5 to first blasting.

Provided herein are protein-like polymers for tuning tau activity. In aspects, provided herein are protein-like polymers for inhibiting tau fibril propagation in a subject.

The invention relates to the technical field of materials, in particular to a hydrothermal reaction system of nanofibers as well as a preparation method and application of the hydrothermal reaction system. The reaction system comprises: a calcium source containing calcium ions; a phosphorus source containing phosphorus ions; a doping source containing lanthanum ions; the invention discloses a structure-directing agent capable of being selectively adsorbed on a hydroxyapatite crystal face under an alkaline condition and inducing one-dimensional directional growth. And an alkaline regulator. According to the preparation method disclosed by the invention, crystallization growth is directly carried out under a hydrothermal condition, and a high-temperature calcination step is not needed, so that the problems of fiber breakage, fusion and morphology collapse caused by macromolecular template decomposition and rapid crystal sintering are fundamentally avoided. The prepared nanofiber has ideal morphology with good continuity, uniform diameter and high length-diameter ratio, and can simulate the microstructure of natural collagen fiber more truly, thereby providing a more excellent biological microenvironment for cells.

This invention discloses a compound that inhibits Aβ aggregation and its application in pharmaceuticals. The novel compound provided by this invention exhibits significantly stronger anti-Aβ aggregation activity than positive control compounds. Aβ protein spontaneously forms aggregates such as oligomers, fibrils, and fibers in the brain. These aggregates lead to neuronal dysfunction and death, ultimately causing neurodegenerative diseases. This invention demonstrates, using a commonly used AD research model in the field, that this novel compound with anti-Aβ aggregation activity possesses significant anti-AD activity.

A method of forming filaments from a lignocellulosic substrate, the method comprising: providing a lignocellulosic substrate (100); growing mushrooms on the lignocellulosic substrate (101); the mushrooms are harvested (102); collecting a lignocellulosic substrate on which mushrooms have grown (103), the substrate being a waste mushroom substrate; the spent mushroom substrate is fibrillated (104) to form filaments. The formed filaments may further form a filament film or foam.

The present invention relates to the use of various extracts of the plant of Rubus suavissimus S. Lee for increasing the firmness and / or elasticity of the skin and / or mucous membranes by increasing the gene and / or protein expression of collagen type I and / or collagen type V and / or LOX-L, perlecan-5, elastin-1 and / or fibrillin-1 in the skin and mucous membranes and / or reducing the CYR61 expression.

The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.