139 results about "Fibril" patented technology

The invention provides an ultralow-swelling artificial cornea imitating natural cornea fiber arrangement and a preparation method, and belongs to the technical field of biomedical materials.The preparation method comprises the steps that I-type collagen is dissolved in a PBS buffer solution, a photofunctionalization modified active reagent is added for chemical modification, stirring is conducted in a dark place, freeze drying is conducted, and photofunctionalization collagen is obtained; dissolving the photo-functionalized collagen, and then preparing a collagen fiber membrane through electrostatic spinning; and performing phase change DLP 3D biological printing on the biological ink and the collagenous fiber membrane to obtain the keratoprosthesis with the collagenous fiber sandwich structure. Multi-layer arrangement is achieved through DLP 3D biological printing, the fiber trend of the natural cornea is simulated, and the mechanical anisotropy is remarkably improved; through a composite phase change DLP 3D printing mode of GelMA / HA-DN and photo-crosslinking collagenous fibers, the composite phase change DLP 3D printing material has good manufacturability, maintains high light transmittance and maintains high mechanical strength.

An oral care composition with retinoid compound, amino acid, and / or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and / or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and / or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.

The invention relates to an antibacterial and mildew-proof wood-bamboo scrimber and a preparation method thereof. According to the preparation method, the pretreated wood-bamboo veneer is defibered through sodium hydroxide and hydrogen peroxide, so that part of starch and carbohydrates can be removed, and mildew is reduced. The prepared inorganic-organic antibacterial and mildewproof composite additive not only realizes a synergistic antibacterial and mildewproof effect and reduces the usage amount, but also realizes broad-spectrum antibacterial effect on bacteria and fungi. The prepared fibrillated wood-bamboo veneer is subjected to alkali / thiourea low-temperature treatment, cellulose can be promoted to be dissolved and regenerated under the action of acid, cellulose fibrils are formed on the surfaces of fibers, the specific surface area is increased, meanwhile, stable coating of the inorganic-organic antibacterial mildew-proof composite additive is improved, and in the pressurizing and forming process, the specific surface area is increased. And antibacterial and mildew-proof effective components are prevented from being lost, and a lasting effect is achieved. The antibacterial and mildew-proof wood-bamboo scrimber prepared by the preparation method disclosed by the invention not only is good in mechanical property, but also has outstanding and long-term antibacterial and mildew-proof properties.

The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.

The invention discloses an implantable acellular matrix material and a preparation method thereof, and belongs to the field of biomedical materials. According to the method, natural animal tissues (such as pericardium, achilles tendon or small intestine submucosa) are used as raw materials, a low-temperature chemical combined decellularization treatment technology is adopted, and the method comprises the multi-step synergistic process of pre-cooling soaking balancing, low-temperature enzymolysis, low-concentration surfactant gradient permeation cleaning, low-temperature nuclease degradation, non-crosslinking sterilization and the like. Under the condition that the treatment temperature is strictly kept at 0-8 DEG C, cell components and genetic materials (the residual DNA content is 1t, and the dry weight is 8 ng / mg) are efficiently removed, and meanwhile the natural three-dimensional fine structure of an extracellular matrix (ECM), the integrity of collagen fibrils and key bioactive components (such as glycosaminoglycans (GAGs)) are reserved to the maximum extent. The host immunological rejection reaction of the obtained material is remarkably reduced, host cell ingrowth, vascularization and tissue function reconstruction can be effectively promoted after implantation, and the material is suitable for high-end implantation scenes such as soft tissue repair and regenerative medical stents.

A multi-layer engineered-wood composite panel or board with a core strand layer, with one or both top and bottom surface layers formed with “fluffy” fiber layers. The fibers may be synthetic or natural. The fibers have anti-settling characteristics. The fibers may be micro-fibrillated cellulose and subsequent cellulose elemental fibrils processed to reduce lignocellulosic recalcitrance and allow the structural integrity of cell walls to be loosened and fibers to be unfolded and exposed. The processed fibers when used as a surface layer provide a denser, smoother and more uniform surface than that obtained with particle-based products.

To provide wet-spinning fibers of β-1,3-glucan containing β-1,3-glucan as the sole constituent molecule and a method for their production, and submicron fibrils and a method for their production.SOLUTION: Wet-spinning fibers containing only β-1,3-glucan represented by a specific chemical formula (1) as a constituent molecule. A method for producing wet-spinning fibers, comprising preparing viscose from a raw material β-1,3-glucan represented by a specific chemical formula (1) (I), or preparing spun fibers from the raw material β-1,3-glucan by a method (II) of dissolving the raw material β-1,3-glucan in a good solvent.SELECTED DRAWING: Figure 5B

The present application provides a collagen fiber material and a preparation method and application thereof, which relate to the field of organic polymer compound processing and also to the field of medical material technology. In the collagen fiber material and the preparation method thereof, polyol dispersion, saturated sodium chloride solution salting out, dispersion liquid re-dispersion, physiological simulation state self-assembly, each step is mutually compatible, and the salt concentration and pH value of each step are strictly controlled, so that the rapid salting out of collagen and aggregation into agglomerates are avoided, and the fiber collagen is stably precipitated without adding a cross-linking agent. The obtained collagen has high mechanical strength and resistance to enzymolysis, and can be used for medical filling, implantation, etc.

The invention relates to a paraffin section detection method fusing Masson and HE dyeing and application, HE dyeing and Masson dyeing are carried out on the same specimen, and information of multiple aspects such as the basic structure of tissue cells, the dyeing condition of cell nucleuses and cytoplasm, the distribution condition of collagenous fibers and muscle fibers and the like can be obtained at the same time. Therefore, a more comprehensive and more accurate basis is provided for diagnosis and research of diseases. By adopting the method and the system, the diagnosis accuracy can be improved, more comprehensive and more accurate information is provided for disease research, and the occurrence mechanism, the development process and the treatment effect of the disease can be deeply known. The tedious process that different dyeing specimens need to be manufactured in a traditional method is avoided, and time and cost are saved. Meanwhile, continuous dyeing detection can be performed on the same specimen, so that the usage amount of the specimen is reduced, and the injury to a patient is reduced.

Provided are microporous and tough PHA-based articles having a knot and fibril structure, as well as processes for making these articles using a less than melt processing manner. In some embodiments, a method of forming a porous expanded PHA composite comprising a porous PHA material can include depositing a partially crystalline polyhydroxyalkanoate (PHA) polymer on a substrate at a deposition temperature below a melting temperature of the PHA polymer to form a PHA-substrate composite, and expanding the PHA-substrate composite at a temperature between the glass transition temperature of the PHA polymer and the melting temperature of the PHA polymer.

Embodiments are directed to a UPEC conjugate peptide including a self-assembling peptide and at least one UPEC epitope. The UPEC conjugate peptide may self-assemble into a nanofiber or fibril. Compositions including the UPEC conjugate peptide may be used to treat a bacterial infection such as a urinary tract infection (UTI). The compositions and methods may be specific for pathogenic bacteria. The compositions and methods may treat the infection without altering the gut microbiome.

The invention discloses a preparation method and application of a degradable cellulose nano-fibril-metal composite material. The preparation method comprises the following steps: S1, preparing a cellulose nano-fibril carrier; S2, chelating metal ions; and S3, carrying out film treatment. The application refers to the application in crop rhizosphere or phyllosphere micronutrient supplement. The invention develops a compound fertilizer system which takes natural cellulose nanofibril as a carrier and chelates trace metal ions through functional groups such as surface carboxyl / hydroxyl and the like, and the compound fertilizer has high specific surface area and stronger metal ion loading capacity; stable loading and slow release are realized through interface adsorption and complexation; the material is completely degradable and is ecological and environment-friendly; the fertilizer can be applied to soil or leaf surfaces and is suitable for various crop types; the process is simplified, and the method has the advantage of convenient industrial popularization.

The present disclosure provides anti-amyloid [beta] (A [beta]) antibodies and antibody fragments that preferentially bind to soluble amyloid [beta] fibrils / oligomers and trigger ADPC in microglial cells; anti-amyloid [beta] (A [beta]) antibodies and antibody fragments that reduce soluble amyloid [beta] fibril / oligomer levels and insoluble amyloid [beta] plaques in brain tissue; and the use of anti-A [beta] fibril / oligomer antibodies and antibody fragments in the treatment, prevention, diagnosis, screening and monitoring of conditions associated with A [beta] protein aggregation, in particular Alzheimer's Disease (AD).

A manufacturing method of a fiber includes: mixing and stirring a plurality of raw materials, to form a mixed liquid, where the plurality of raw materials includes dry copper nanopowder with a particle size not more than 48 nm, a fiber slurry, and an additive; drying the mixed liquid, to remove moisture of the mixed liquid and form a processed raw material; heating the processed raw material, to make the processed raw material be in a semi-molten state; electrifying the processed raw material in the semi-molten state, and then extruding at least one fibril from the processed raw material in the semi-molten state; stretching the at least one fibril; and performing cooling and shaping on at least one stretched fibril, to form a final fiber product.

The invention relates to the use of scyllo-inositol alone or in combination with other active ingredients including the compound N-acetylcysteine or a derivative thereof to support cognitive health in a subject that takes the product or combination product. The compositions, which are inclusive of oral dosage forms such as tablets or capsules, are provided to the subject which is inclusive of humans or other mammals such as dogs or cats or other animals in need of cognitive improvement. The combination product(s) break up amyloid beta aggregates and promote the clearance of amyloid beta fibrils from the glymphatic system as well as the treatment of disease and conditions that are acerbated by free radicals.

To provide a cellulose pulp excellent in both particle trapping property and binder property, and to provide a method for producing the cellulose pulp, since beaten fibers are used in a variety of fields due to their excellent ability to capture functional particles, but there are also applications that require not only particle trapping property but also binder property, pulp-like acrylonitrile fibers are known as beaten fibers that combine these properties, but in recent years the environmental impact of plastic waste has become an issue and there has been a demand for a shift to bio-based materials, while conventional bio-based materials containing cellulose have not necessarily been satisfactory in terms of combining the above-mentioned properties.SOLUTION: The cellulose pulp according to the present invention is characterized in that the cellulose pulp fibril area is 15% or more and the fibril area(%) / 100×fine(%) / 100 is 0.05 or more.SELECTED DRAWING: None

The invention discloses a bionic heterogeneous tissue engineering meniscus stent and a preparation method thereof, and discloses application of the bionic heterogeneous tissue engineering meniscus stent in the field of meniscus repair. Based on a multi-nozzle 3D printing technology, a biodegradable high polymer material and bio-ink loaded with growth factors / stem cells are innovatively adopted, and the highly bionic heterogeneous tissue engineering meniscus is constructed. Specifically, degradable macromolecular polycaprolactone (PCL) is used as a raw material, and annular and radial fibers are printed to form a stent frame by accurately regulating and controlling a printing path and simulating a natural meniscus collagenous fiber distribution rule; on the basis, biological ink loaded with differentiated growth factors and stem cells is printed in a staggered manner according to different physiological characteristics of a red region and a white region of the meniscus, so that partitioned precise inoculation of seed cells and controllable partitioned release of the growth factors are realized, and a cell microenvironment with spatial specificity is provided for meniscus regeneration; the tissue repair efficiency and the bionic integrating degree are obviously improved.

The present invention relates to (i) a bonded sheet of nonwoven flash-spun plexifilamentary fibrils exhibiting a high degree of breathability and good surface robustness, (ii) a process for the preparation of a bonded sheet of nonwoven flash-spun plexifilamentary fibrils, and (iii) a multilayer sheet structure and an article comprising the bonded sheet of nonwoven flash-spun plexifilamentary fibrils.

The present invention provides a guided bone regeneration (GBR) material with antibacterial properties. The GBR material is a multi-component material, including an eggshell membrane (ESM) which is functionalized by mineralization in the presence of low-molecular-weight polyacrylic acid (LPAA). Thus, the ESM therefore includes at least one mineral deposited therein, preferably, intrafibrillar deposition, for example apatite and effective amounts of LPAA. The mineralized GBR material is preferably porous, and has good mechanical properties. A method of making mineralized GBR material which preferably contains intrafibrillar mineralization is also provided.

The invention belongs to the technical field of biomedical materials, and particularly relates to biomimetic mineralized II-type collagen hydrogel as well as a preparation method and application thereof. The method comprises the following steps: gelling an acid solution of type II collagen in an alkaline environment to obtain type II collagen hydrogel; and dipping the type II collagen hydrogel in a mineralizing solution for mineralization to obtain the biomimetic mineralized type II collagen hydrogel. According to the method provided by the invention, the complex shape and nano-scale characteristics of the collagen fiber template can be accurately filled and copied, and the obtained biomimetic mineralized II-type collagen hydrogel can realize a tissue bionic effect. The biomimetic mineralized gel prepared by the invention has type I and type II amido bonds, the unmineralized collagenous fiber has a 67nm D-banding periodic structure, and hydroxyapatite crystals in the mineralized collagenous fiber are distributed along a long axis of collagen fibril composed of type II collagen, so that mineralization in the collagenous fiber is realized.

The present application belongs to the field of biomedical materials, and particularly relates to collagen fibers with mesoscopic aggregates as structural units for biomedical materials and a preparation method thereof. The preparation method comprises the following steps in sequence: a step of splitting natural collagen aggregates from animal tissues, a step of regulating the mesoscopic size of the natural collagen aggregates, a step of assembling a fiber preparation device, a step of preparing collagen fibers with the natural collagen aggregates as structural units, and a step of twisting the collagen fibers. Compared with conventional solution method for preparing collagen fibers, the present application uses mesoscopic aggregates as structural units for preparing collagen fibers, and the obtained fibers have excellent mechanical properties, good biocompatibility and wound healing promoting performance.

The present invention relates to specific antibodies and use thereof, such as for identifying and / or quantifying liraglutide fibrils and / or semaglutide fibrils.

The present invention includes a method of treating fibrosis in a human patient in need thereof comprising administering to the human patient in need of treatment a therapeutically effective amount of Prolactin-Inducible Protein (PIP) which is capable of inhibiting or reversing the formation of pathogenic fibrils, e g., fibrosis that affects at least one organ selected from the group consisting of skin, intestine, heart, liver, lung, and kidney.

The present invention relates to specific antibodies and uses thereof, for example, for identifying and / or quantifying liraglutide fibrils and / or semeglutide fibrils.

A system and method for protein detection are provided, configured to non-invasively identify proteins exhibiting specific structural conformations within a biological target. The system comprises a light source operable to irradiate the target at a predetermined pulse cycle, a sound detection device configured to capture acoustic signals generated via the photoacoustic effect, and an information processing unit that analyzes the detected acoustic signals to determine the presence or accumulation of a target protein. This technique facilitates early-stage detection of disease-associated proteins, such as amyloid-β and misfolded α-synuclein fibrils, without requiring complex imaging modalities or invasive biopsy procedures.

The present technique pertains to a method of preparation of a succinylated collagen-fibrinogen hydrogel and a succinylated collagen-fibrinogen hydrogel prepared thereby. The method of preparation of a succinylated collagen-fibrinogen hydrogel according to the present technique can produce a collagen-based bio-substance in a simple process, wherein collagen can be prevented from being entangled and an improvement can be brought about in hydrophilicity, cell growth rate, cell compatibility, and cell diffusion capability, whereby the collagen-based bio-substance exhibits excellent biocompatibility in vivo.

The invention relates to a method of producing a fibrillary dry adhesive material having a plurality of fibrils. Furthermore, the invention relates to a fibrillar dry adhesive material in particular having liquid super-repellency.

The present invention discloses a method for producing a sorbent, comprising the steps of providing oxidized nanocellulose fibrils and reacting the oxidized nanocellulose fibrils with aminooxysilane. Furthermore, a sorbent, the use of the sorbent, and a method for sorbing CO2 are disclosed.